Aliases for TM9SF4 Gene
External Ids for TM9SF4 Gene
Previous GeneCards Identifiers for TM9SF4 Gene
GeneCards Summary for TM9SF4 Gene
TM9SF4 (Transmembrane 9 Superfamily Member 4) is a Protein Coding gene. An important paralog of this gene is TM9SF2.
UniProtKB/Swiss-Prot for TM9SF4 Gene
Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).