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Aliases for TM9SF4 Gene

Aliases for TM9SF4 Gene

  • Transmembrane 9 Superfamily Member 4 2 3 5
  • Dinucleotide Oxidase Disulfide Thiol Exchanger 3 Superfamily Member 4 3
  • Transmembrane 9 Superfamily Protein Member 4 3
  • DJ836N17.2 3
  • KIAA0255 4

External Ids for TM9SF4 Gene

Previous GeneCards Identifiers for TM9SF4 Gene

  • GC20P031395
  • GC20P031442
  • GC20P030161
  • GC20P030184
  • GC20P030697
  • GC20P027486

Summaries for TM9SF4 Gene

GeneCards Summary for TM9SF4 Gene

TM9SF4 (Transmembrane 9 Superfamily Member 4) is a Protein Coding gene. An important paralog of this gene is TM9SF2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM9SF4 Gene

Genomics for TM9SF4 Gene

Regulatory Elements for TM9SF4 Gene

Enhancers for TM9SF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TM9SF4 on UCSC Golden Path with GeneCards custom track

Promoters for TM9SF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TM9SF4 Gene

32,109,506 bp from pter
32,167,258 bp from pter
57,753 bases
Plus strand

Genomic View for TM9SF4 Gene

Genes around TM9SF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM9SF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM9SF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM9SF4 Gene

Proteins for TM9SF4 Gene

  • Protein details for TM9SF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 9 superfamily member 4
    Protein Accession:
    Secondary Accessions:
    • B0QYT7
    • Q9NUA3

    Protein attributes for TM9SF4 Gene

    642 amino acids
    Molecular mass:
    74519 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH21107.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA13385.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TM9SF4 Gene

Post-translational modifications for TM9SF4 Gene

  • Ubiquitination at Lys 72
  • Modification sites at PhosphoSitePlus

Other Protein References for TM9SF4 Gene

No data available for DME Specific Peptides for TM9SF4 Gene

Domains & Families for TM9SF4 Gene

Gene Families for TM9SF4 Gene

Protein Domains for TM9SF4 Gene


Suggested Antigen Peptide Sequences for TM9SF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
genes like me logo Genes that share domains with TM9SF4: view

Function for TM9SF4 Gene

genes like me logo Genes that share phenotypes with TM9SF4: view

Animal Models for TM9SF4 Gene

MGI Knock Outs for TM9SF4:

Animal Model Products

  • Taconic Biosciences Mouse Models for TM9SF4

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TM9SF4 Gene

Localization for TM9SF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM9SF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM9SF4 Gene COMPARTMENTS Subcellular localization image for TM9SF4 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TM9SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TM9SF4: view

Pathways & Interactions for TM9SF4 Gene

SuperPathways for TM9SF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TM9SF4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM9SF4 Gene

Drugs & Compounds for TM9SF4 Gene

No Compound Related Data Available

Transcripts for TM9SF4 Gene

Unigene Clusters for TM9SF4 Gene

Transmembrane 9 superfamily protein member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF4 Gene

No ASD Table

Relevant External Links for TM9SF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM9SF4 Gene

mRNA expression in normal human tissues for TM9SF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TM9SF4 Gene

This gene is overexpressed in Liver (9.1) and Adrenal (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TM9SF4 Gene

Protein tissue co-expression partners for TM9SF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TM9SF4 Gene:


SOURCE GeneReport for Unigene cluster for TM9SF4 Gene:

genes like me logo Genes that share expression patterns with TM9SF4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TM9SF4 Gene

Orthologs for TM9SF4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TM9SF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM9SF4 34
  • 93.09 (n)
  • 98.6 (a)
TM9SF4 35
  • 99 (a)
(Canis familiaris)
Mammalia TM9SF4 34
  • 93.2 (n)
  • 98.6 (a)
TM9SF4 35
  • 99 (a)
(Mus musculus)
Mammalia Tm9sf4 34
  • 91.48 (n)
  • 96.88 (a)
Tm9sf4 16
Tm9sf4 35
  • 97 (a)
(Pan troglodytes)
Mammalia TM9SF4 34
  • 99.79 (n)
  • 100 (a)
TM9SF4 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Tm9sf4 34
  • 91.8 (n)
  • 96.88 (a)
(Monodelphis domestica)
Mammalia TM9SF4 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
(Gallus gallus)
Aves TM9SF4 34
  • 81.38 (n)
  • 91.89 (a)
TM9SF4 35
  • 92 (a)
(Anolis carolinensis)
Reptilia TM9SF4 35
  • 90 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398864 34
(Danio rerio)
Actinopterygii tm9sf4 34
  • 76.56 (n)
  • 84.84 (a)
zgc66234 34
tm9sf4 35
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010029 34
  • 62.38 (n)
  • 65.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta TM9SF4 34
  • 65.47 (n)
  • 65.85 (a)
TM9SF4 35
  • 64 (a)
(Caenorhabditis elegans)
Secernentea ZK858.6 34
  • 58.22 (n)
  • 58.61 (a)
ZK858.6 35
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP70 35
  • 36 (a)
TMN2 35
  • 33 (a)
EMP70 37
thale cress
(Arabidopsis thaliana)
eudicotyledons TMN7 34
  • 59.06 (n)
  • 54.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4614 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
Species where no ortholog for TM9SF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TM9SF4 Gene

Gene Tree for TM9SF4 (if available)
Gene Tree for TM9SF4 (if available)

Paralogs for TM9SF4 Gene

Paralogs for TM9SF4 Gene

(4) SIMAP similar genes for TM9SF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TM9SF4: view

Variants for TM9SF4 Gene

Sequence variations from dbSNP and Humsavar for TM9SF4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs14086 -- 32,166,827(+) CACCA(G/T)CCCTT utr-variant-3-prime
rs14316 -- 32,165,467(+) CAAGC(C/T)TGCTC utr-variant-3-prime
rs910186 -- 32,117,449(+) GAGAA(A/G)TGCAA intron-variant
rs926689 -- 32,128,413(+) TAGGG(C/T)AGGGC intron-variant
rs2143764 -- 32,139,171(+) AGTGC(C/T)GGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM9SF4 Gene

Variant ID Type Subtype PubMed ID
nsv833953 CNV loss 17160897
nsv833954 CNV loss 17160897

Variation tolerance for TM9SF4 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM9SF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM9SF4 Gene

Disorders for TM9SF4 Gene

Relevant External Links for TM9SF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM9SF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM9SF4 Gene

Publications for TM9SF4 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 65
  2. TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cells. (PMID: 25659576) Lozupone F. … Fais S. (Oncogene 2015) 2 3 65
  3. TM9 family proteins control surface targeting of glycine-rich transmembrane domains. (PMID: 25999474) Perrin J. … Cosson P. (J. Cell. Sci. 2015) 2 3 65
  4. The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells. (PMID: 19893578) Lozupone F. … Fais S. (EMBO Rep. 2009) 3 22 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for TM9SF4 Gene

Sources for TM9SF4 Gene

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