TM9SF4 Gene
protein-coding GIFtS: 50
GCID: GC20P030697
|
|
transmembrane 9 superfamily protein member 4
| |
Aliases
for TM9SF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane 9 Superfamily Protein Member 41 2 | | DJ836N17.21 | | KIAA02551 3 | | Transmembrane 9 Superfamily Member 42 |
Export aliases for TM9SF4 gene to outside databasesPrevious GC identifers: GC20P031395 GC20P031442 GC20P030161 GC20P030184 GC20P027486 |
Summaries
for TM9SF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TM9SF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TM9SF4 gene promoter:
COUP-TF1 TBP GCNF COUP HNF-4alpha2 RelA HNF-4alpha1 COUP-TF GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TM9SF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM9SF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.21 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.21TM9SF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P030697: view genomic region
(about GC identifiers)
Start:
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30,697,309 bp from pter |
End:
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30,755,061 bp from pter |
Size:
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57,753 bases |
Orientation:
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plus strand |
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Proteins
for TM9SF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM9S4_HUMAN, Q92544 (See
protein sequence)Recommended Name: Transmembrane 9 superfamily member 4 precursor Size: 642 amino acids; 74519 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)
Sequence caution: Sequence=AAH21107.1; Type=Erroneous initiation; Sequence=BAA13385.2; Type=Erroneous initiation;
Secondary accessions: B0QYT7 Q9NUA3Explore the universe of human proteins at neXtProt for TM9SF4: NX_Q92544
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92544
TM9SF4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055557.2
ENSEMBL proteins: ENSP00000381104 ENSP00000413382 ENSP00000390314 ENSP00000217315 ENSP00000404755
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TM9SF4 for ontologies About GeneDecksing
TM9SF4 Antibody Products:
Assay Products for TM9SF4: |
Protein
Domains /
Families
for TM9SF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TM9SF4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q92544ProtoNet protein and cluster: Q92544 1 Blocks protein family: IPB004240 Nonaspanin (TM9SF)
UniProtKB/Swiss-Prot: TM9S4_HUMAN, Q92544Similarity: Belongs to the nonaspanin (TM9SF) family |
Function
for TM9SF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TM9SF4 (NM_014742) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM9SF4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM9SF4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF4 |
1 GenomeRNAi human phenotype for TM9SF4:
Animal Models:
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Tm9sf4):
TM9SF4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TM9SF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TM9SF4
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/14 Interacting proteins for TM9SF4 (Q925442, 3 ENSP000003811044) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
|
Drugs & Compounds
for TM9SF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TM9SF4
Search CenterWatch for drugs/clinical trials and news about TM9SF4 / TM9S4
|
Transcripts
for TM9SF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TM9SF4 gene: NM_014742.3 Unigene Cluster for TM9SF4: Transmembrane 9 superfamily protein member 4 Hs.654665 [show with all ESTs]Unigene Representative Sequence: D874447 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398022(uc010ztr.1 uc002wxj.2 uc010zts.1) ENST00000442842
ENST00000450829 ENST00000217315(uc002wxk.2) ENST00000417389 ENST00000495749
ENST00000479591
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TM9SF4 (NM_014742) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM9SF4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM9SF4 |
Additional cDNA sequence: AK124411.1 AK126534.1 AK294980.1 AK296500.1 AK302439.1 AK316293.1 BC005173.2 BC021107.1 BC022850.2 D87444.1 16 DOTS entries: DT.448936 DT.99942986 DT.100821109 DT.40264054 DT.100655010 DT.100821127 DT.92446720 DT.100821128 DT.40281764 DT.120808427 DT.120808532 DT.92409358 DT.92446714 DT.95125992 DT.100011944 DT.95361393 24/354 AceView cDNA sequences (see all 354): BM976489 AA505288 AI359797 AW071542 AI922862 AA300794 BU538209 CA394983 AI337232 CR610143 BM761750 CR611710 BC021107 BM844318 AI360188 CD671380 BG060060 AI362874 BQ227878 AI364237 BE867938 BU184579 AI356823 BU190046
GeneLoc Exon Structure
|
Expression
for TM9SF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TM9SF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATCACAAA
About this image
See TM9SF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TM9SF4
SOURCE GeneReport for Unigene cluster: Hs.654665
SABiosciences Custom PCR Arrays for TM9SF4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM9SF4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TM9SF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM9SF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM9SF4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF4 |
Orthologs
for TM9SF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TM9SF4 gene from 8/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TM9SF41 |
transmembrane 9 superfamily protein member 4 |
81.52(n)
92.6(a) |
|
419281 XM_417455.3 XP_417455.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TM9SF46 |
-- |
90(a) |
1 ↔ 1 |
GL343505.1(422874-435278) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3988642 |
hypothetical protein LOC398864 |
80.51(n) |
|
BC060487.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc662342 |
hypothetical protein MGC66234 |
76.93(n) |
|
393482 BC055558.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
TM9SF41 |
CG7364-PA |
65.47(n)
65.85(a) |
|
34778 NM_135825.3 NP_609669.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK858.61 |
Protein ZK858.6 |
58.06(n)
58.28(a) |
|
172739 NM_001136332.1 NP_001129804.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G108401 |
endomembrane family protein 70 |
58.25(n)
53.49(a) |
|
830951 NM_121122.3 NP_196645.2 |
rice
(Oryza sativa) |
Liliopsida |
AK066545.12 |
-- |
73.07(n) |
|
AK066545.1 |
ENSEMBL Gene Tree for TM9SF4 (if available)
TreeFam Gene Tree for TM9SF4 (if available) |
Paralogs
for TM9SF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TM9SF4 gene
- TM9SF32 ENSG000002546922 ENSG000002595222 TM9SF22 TM9SF12
4 SIMAP similar genes for TM9SF4 using alignment to 3 protein entries: TM9S4_HUMAN (see all proteins):TM9SF2 TM9SF3 TM9SF1 SMBP
TM9SF4 for paralogs About GeneDecksing
|
Genomic Variants
for TM9SF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TM9SF4 (30697309 - 30755061 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TM9SF4
1 CNV: 5132 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM9SF4 |
|
Disorders
/ Diseases
for TM9SF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TM9SF4 for disorders About GeneDecksing
2  diseases for TM9SF4: About MalaCardsmelanoma malaria
Export disorders for TM9SF4 gene to outside databases
|
Publications
for TM9SF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TM9SF4 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TM9SF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2, 3 Nagase T....Nomura N. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells. (PubMed id 19893578)1, 9 Lozupone F....Fais S. (2009)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (2008)
|
External Searches for TM9SF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TM9SF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TM9SF4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TM9SF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TM9SF4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TM9SF4 gene:
Search GeneIP for patents involving TM9SF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TM9SF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TM9SF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TM9SF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM9SF4 | | | OriGene Protein Over-expression Lysate for TM9SF4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TM9SF4 | | OriGene 3'-UTR Clone for TM9SF4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TM9SF4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM9SF4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM9SF4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TM9SF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM9SF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM9SF4 |
| |
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| | | | Search Tocris compounds for TM9SF4 |
| |  |  |  |  | | | | |
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 | | | TM9SF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF4 |
|  |  |  | | | | Search ThermoFisher Antibodies for TM9SF4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM9SF4 |
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