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Aliases for TM9SF4 Gene

Aliases for TM9SF4 Gene

  • Transmembrane 9 Superfamily Protein Member 4 2 3
  • Dinucleotide Oxidase Disulfide Thiol Exchanger 3 Superfamily Member 4 3
  • Transmembrane 9 Superfamily Member 4 3
  • DJ836N17.2 3
  • KIAA0255 4

External Ids for TM9SF4 Gene

Previous GeneCards Identifiers for TM9SF4 Gene

  • GC20P031395
  • GC20P031442
  • GC20P030161
  • GC20P030184
  • GC20P030697
  • GC20P027486

Summaries for TM9SF4 Gene

GeneCards Summary for TM9SF4 Gene

TM9SF4 (Transmembrane 9 Superfamily Protein Member 4) is a Protein Coding gene. An important paralog of this gene is TM9SF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM9SF4 Gene

Genomics for TM9SF4 Gene

Regulatory Elements for TM9SF4 Gene

Genomic Location for TM9SF4 Gene

Start:
32,109,506 bp from pter
End:
32,167,258 bp from pter
Size:
57,753 bases
Orientation:
Plus strand

Genomic View for TM9SF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TM9SF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM9SF4 Gene

Proteins for TM9SF4 Gene

  • Protein details for TM9SF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92544-TM9S4_HUMAN
    Recommended name:
    Transmembrane 9 superfamily member 4
    Protein Accession:
    Q92544
    Secondary Accessions:
    • B0QYT7
    • Q9NUA3

    Protein attributes for TM9SF4 Gene

    Size:
    642 amino acids
    Molecular mass:
    74519 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH21107.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA13385.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TM9SF4 Gene

Proteomics data for TM9SF4 Gene at MOPED

Post-translational modifications for TM9SF4 Gene

  • Ubiquitination at Lys72
  • Modification sites at PhosphoSitePlus

Other Protein References for TM9SF4 Gene

No data available for DME Specific Peptides for TM9SF4 Gene

Domains for TM9SF4 Gene

Protein Domains for TM9SF4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TM9SF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92544

UniProtKB/Swiss-Prot:

TM9S4_HUMAN :
  • Q92544
Family:
  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
genes like me logo Genes that share domains with TM9SF4: view

No data available for Gene Families for TM9SF4 Gene

Function for TM9SF4 Gene

Phenotypes for TM9SF4 Gene

genes like me logo Genes that share phenotypes with TM9SF4: view

miRNA for TM9SF4 Gene

miRTarBase miRNAs that target TM9SF4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TM9SF4 Gene

Localization for TM9SF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM9SF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TM9SF4 Gene COMPARTMENTS Subcellular localization image for TM9SF4 gene
Compartment Confidence
plasma membrane 3
endosome 1

Gene Ontology (GO) - Cellular Components for TM9SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM9SF4: view

Pathways for TM9SF4 Gene

SuperPathways for TM9SF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TM9SF4 Gene

None

No data available for Pathways by source for TM9SF4 Gene

Transcripts for TM9SF4 Gene

Unigene Clusters for TM9SF4 Gene

Transmembrane 9 superfamily protein member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF4 Gene

No ASD Table

Relevant External Links for TM9SF4 Gene

GeneLoc Exon Structure for
TM9SF4
ECgene alternative splicing isoforms for
TM9SF4

Expression for TM9SF4 Gene

mRNA expression in normal human tissues for TM9SF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM9SF4 Gene

SOURCE GeneReport for Unigene cluster for TM9SF4 Gene Hs.654665

genes like me logo Genes that share expressions with TM9SF4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TM9SF4 Gene

Orthologs for TM9SF4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TM9SF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM9SF4 35
  • 99.79 (n)
  • 100 (a)
TM9SF4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TM9SF4 35
  • 93.09 (n)
  • 98.6 (a)
TM9SF4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TM9SF4 35
  • 93.2 (n)
  • 98.6 (a)
TM9SF4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tm9sf4 35
  • 91.48 (n)
  • 96.88 (a)
Tm9sf4 16
Tm9sf4 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TM9SF4 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tm9sf4 35
  • 91.8 (n)
  • 96.88 (a)
chicken
(Gallus gallus)
Aves TM9SF4 35
  • 81.38 (n)
  • 91.89 (a)
TM9SF4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TM9SF4 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398864 35
zebrafish
(Danio rerio)
Actinopterygii tm9sf4 35
  • 76.56 (n)
  • 84.84 (a)
tm9sf4 36
  • 84 (a)
OneToOne
zgc66234 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010029 35
  • 62.38 (n)
  • 65.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta TM9SF4 35
  • 65.47 (n)
  • 65.85 (a)
TM9SF4 36
  • 64 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK858.6 35
  • 58.22 (n)
  • 58.61 (a)
ZK858.6 36
  • 54 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP70 36
  • 36 (a)
ManyToMany
EMP70 38
TMN2 36
  • 33 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons TMN7 35
  • 59.06 (n)
  • 54.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4614 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for TM9SF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TM9SF4 Gene

ENSEMBL:
Gene Tree for TM9SF4 (if available)
TreeFam:
Gene Tree for TM9SF4 (if available)

Paralogs for TM9SF4 Gene

Paralogs for TM9SF4 Gene

Selected SIMAP similar genes for TM9SF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TM9SF4: view

Variants for TM9SF4 Gene

Sequence variations from dbSNP and Humsavar for TM9SF4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs14086 -- 32,166,827(+) CACCA(G/T)CCCTT utr-variant-3-prime
rs14316 -- 32,165,467(+) CAAGC(C/T)TGCTC utr-variant-3-prime
rs910186 -- 32,117,449(+) GAGAA(A/G)TGCAA intron-variant
rs926689 -- 32,128,413(+) TAGGG(C/T)AGGGC intron-variant
rs1050659 -- 32,166,437(+) CCCAG(A/G)GATTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TM9SF4 Gene

Variant ID Type Subtype PubMed ID
nsv833953 CNV Loss 17160897
nsv833954 CNV Loss 17160897

Relevant External Links for TM9SF4 Gene

HapMap Linkage Disequilibrium report
TM9SF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM9SF4 Gene

Disorders for TM9SF4 Gene

No disorders were found for TM9SF4 Gene.

No data available for UniProtKB/Swiss-Prot for TM9SF4 Gene

Publications for TM9SF4 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells. (PMID: 19893578) Lozupone F. … Fais S. (EMBO Rep. 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TM9SF4 Gene

  • antibodies-online peptides for TM9SF4
  • antibodies-online antibodies for TM9SF4
  • antibodies-online kits for TM9SF4

Sources for TM9SF4 Gene

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