Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TM9SF4 Gene

Aliases for TM9SF4 Gene

  • Transmembrane 9 Superfamily Member 4 2 3
  • Transmembrane 9 Superfamily Protein Member 4 3 5
  • Dinucleotide Oxidase Disulfide Thiol Exchanger 3 Superfamily Member 4 3
  • DJ836N17.2 3
  • KIAA0255 4

External Ids for TM9SF4 Gene

Previous GeneCards Identifiers for TM9SF4 Gene

  • GC20P031395
  • GC20P031442
  • GC20P030161
  • GC20P030184
  • GC20P030697
  • GC20P027486

Summaries for TM9SF4 Gene

GeneCards Summary for TM9SF4 Gene

TM9SF4 (Transmembrane 9 Superfamily Member 4) is a Protein Coding gene. An important paralog of this gene is TM9SF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM9SF4 Gene

Genomics for TM9SF4 Gene

Regulatory Elements for TM9SF4 Gene

Promoters for TM9SF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TM9SF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM9SF4 Gene

32,109,506 bp from pter
32,167,258 bp from pter
57,753 bases
Plus strand

Genomic View for TM9SF4 Gene

Genes around TM9SF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM9SF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM9SF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM9SF4 Gene

Proteins for TM9SF4 Gene

  • Protein details for TM9SF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 9 superfamily member 4
    Protein Accession:
    Secondary Accessions:
    • B0QYT7
    • Q9NUA3

    Protein attributes for TM9SF4 Gene

    642 amino acids
    Molecular mass:
    74519 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH21107.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA13385.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TM9SF4 Gene

Proteomics data for TM9SF4 Gene at MOPED

Post-translational modifications for TM9SF4 Gene

  • Ubiquitination at Lys 72
  • Modification sites at PhosphoSitePlus

Other Protein References for TM9SF4 Gene

No data available for DME Specific Peptides for TM9SF4 Gene

Domains & Families for TM9SF4 Gene

Gene Families for TM9SF4 Gene

Protein Domains for TM9SF4 Gene


Suggested Antigen Peptide Sequences for TM9SF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
genes like me logo Genes that share domains with TM9SF4: view

Function for TM9SF4 Gene

genes like me logo Genes that share phenotypes with TM9SF4: view

Animal Models for TM9SF4 Gene

MGI Knock Outs for TM9SF4:

Animal Model Products

  • Taconic Biosciences Mouse Models for TM9SF4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TM9SF4 Gene

Localization for TM9SF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM9SF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM9SF4 Gene COMPARTMENTS Subcellular localization image for TM9SF4 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for TM9SF4 Gene

Pathways & Interactions for TM9SF4 Gene

SuperPathways for TM9SF4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TM9SF4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM9SF4 Gene

Drugs & Compounds for TM9SF4 Gene

No Compound Related Data Available

Transcripts for TM9SF4 Gene

Unigene Clusters for TM9SF4 Gene

Transmembrane 9 superfamily protein member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF4 Gene

No ASD Table

Relevant External Links for TM9SF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM9SF4 Gene

mRNA expression in normal human tissues for TM9SF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TM9SF4 Gene

This gene is overexpressed in Liver (9.1) and Adrenal (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM9SF4 Gene

SOURCE GeneReport for Unigene cluster for TM9SF4 Gene Hs.654665

genes like me logo Genes that share expression patterns with TM9SF4: view

Protein tissue co-expression partners for TM9SF4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TM9SF4 Gene

Orthologs for TM9SF4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TM9SF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM9SF4 35
  • 93.09 (n)
  • 98.6 (a)
TM9SF4 36
  • 99 (a)
(Canis familiaris)
Mammalia TM9SF4 35
  • 93.2 (n)
  • 98.6 (a)
TM9SF4 36
  • 99 (a)
(Mus musculus)
Mammalia Tm9sf4 35
  • 91.48 (n)
  • 96.88 (a)
Tm9sf4 16
Tm9sf4 36
  • 97 (a)
(Pan troglodytes)
Mammalia TM9SF4 35
  • 99.79 (n)
  • 100 (a)
TM9SF4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tm9sf4 35
  • 91.8 (n)
  • 96.88 (a)
(Monodelphis domestica)
Mammalia TM9SF4 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Gallus gallus)
Aves TM9SF4 35
  • 81.38 (n)
  • 91.89 (a)
TM9SF4 36
  • 92 (a)
(Anolis carolinensis)
Reptilia TM9SF4 36
  • 90 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398864 35
(Danio rerio)
Actinopterygii tm9sf4 35
  • 76.56 (n)
  • 84.84 (a)
zgc66234 35
tm9sf4 36
  • 84 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010029 35
  • 62.38 (n)
  • 65.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta TM9SF4 35
  • 65.47 (n)
  • 65.85 (a)
TM9SF4 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea ZK858.6 35
  • 58.22 (n)
  • 58.61 (a)
ZK858.6 36
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP70 36
  • 36 (a)
TMN2 36
  • 33 (a)
EMP70 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TMN7 35
  • 59.06 (n)
  • 54.52 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4614 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
Species with no ortholog for TM9SF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TM9SF4 Gene

Gene Tree for TM9SF4 (if available)
Gene Tree for TM9SF4 (if available)

Paralogs for TM9SF4 Gene

Paralogs for TM9SF4 Gene

(4) SIMAP similar genes for TM9SF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TM9SF4: view

Variants for TM9SF4 Gene

Sequence variations from dbSNP and Humsavar for TM9SF4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs14086 -- 32,166,827(+) CACCA(G/T)CCCTT utr-variant-3-prime
rs14316 -- 32,165,467(+) CAAGC(C/T)TGCTC utr-variant-3-prime
rs1205843 -- 32,155,193(+) TAAGT(G/T)CCTCC intron-variant
rs1803425 -- 32,167,086(+) TTTTT(C/T)CCCTA utr-variant-3-prime
rs1803426 -- 32,165,501(+) TGCGT(A/G)GGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TM9SF4 Gene

Variant ID Type Subtype PubMed ID
nsv833953 CNV Loss 17160897
nsv833954 CNV Loss 17160897

Variation tolerance for TM9SF4 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM9SF4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM9SF4 Gene

Disorders for TM9SF4 Gene

Relevant External Links for TM9SF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM9SF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM9SF4 Gene

Publications for TM9SF4 Gene

  1. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3 4 67
  2. The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells. (PMID: 19893578) Lozupone F. … Fais S. (EMBO Rep. 2009) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for TM9SF4 Gene

Sources for TM9SF4 Gene

Back to Top