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Aliases for TM9SF3 Gene

Aliases for TM9SF3 Gene

  • Transmembrane 9 Superfamily Member 3 2 3 5
  • SM-11044-Binding Protein 3 4
  • EP70-P-Iso 3 4
  • SMBP 3 4
  • Dinucleotide Oxidase Disulfide Thiol Exchanger 3 Superfamily Member 3 3
  • Endomembrane Protein Emp70 Precursor Isolog 3
  • SM-11044 Binding Protein 3

External Ids for TM9SF3 Gene

Previous GeneCards Identifiers for TM9SF3 Gene

  • GC10M098267
  • GC10M091907

Summaries for TM9SF3 Gene

GeneCards Summary for TM9SF3 Gene

TM9SF3 (Transmembrane 9 Superfamily Member 3) is a Protein Coding gene. An important paralog of this gene is TM9SF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM9SF3 Gene

Genomics for TM9SF3 Gene

Regulatory Elements for TM9SF3 Gene

Promoters for TM9SF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TM9SF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM9SF3 Gene

Chromosome:
10
Start:
96,518,109 bp from pter
End:
96,587,452 bp from pter
Size:
69,344 bases
Orientation:
Minus strand

Genomic View for TM9SF3 Gene

Genes around TM9SF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM9SF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM9SF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM9SF3 Gene

Proteins for TM9SF3 Gene

  • Protein details for TM9SF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD45-TM9S3_HUMAN
    Recommended name:
    Transmembrane 9 superfamily member 3
    Protein Accession:
    Q9HD45
    Secondary Accessions:
    • Q5TB57
    • Q6UWE7
    • Q9NWL8
    • Q9P0G9
    • Q9UHW8

    Protein attributes for TM9SF3 Gene

    Size:
    589 amino acids
    Molecular mass:
    67888 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF67014.1; Type=Frameshift; Positions=184, 198, 370, 446; Evidence={ECO:0000305}; Sequence=AAQ89178.1; Type=Frameshift; Positions=70; Evidence={ECO:0000305}; Sequence=BAA91362.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TM9SF3 Gene

Proteomics data for TM9SF3 Gene at MOPED

Post-translational modifications for TM9SF3 Gene

  • Ubiquitination at Lys 59 and Lys 210
  • Glycosylation at Asn 174 and Asn 419
  • Modification sites at PhosphoSitePlus

Other Protein References for TM9SF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TM9SF3 Gene

Domains & Families for TM9SF3 Gene

Gene Families for TM9SF3 Gene

Protein Domains for TM9SF3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD45

UniProtKB/Swiss-Prot:

TM9S3_HUMAN :
  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
Family:
  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
genes like me logo Genes that share domains with TM9SF3: view

Function for TM9SF3 Gene

Phenotypes for TM9SF3 Gene

genes like me logo Genes that share phenotypes with TM9SF3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TM9SF3

miRNA for TM9SF3 Gene

miRTarBase miRNAs that target TM9SF3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM9SF3 Gene

Localization for TM9SF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM9SF3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TM9SF3 Gene COMPARTMENTS Subcellular localization image for TM9SF3 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for TM9SF3 Gene

Pathways & Interactions for TM9SF3 Gene

SuperPathways for TM9SF3 Gene

No Data Available

Interacting Proteins for TM9SF3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000360184%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000227471%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: Q9HD45-TM9S3_HUMAN ENSP00000360184 for TM9SF3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TM9SF3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TM9SF3 Gene

Drugs & Compounds for TM9SF3 Gene

No Compound Related Data Available

Transcripts for TM9SF3 Gene

Unigene Clusters for TM9SF3 Gene

Transmembrane 9 superfamily member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF3 Gene

No ASD Table

Relevant External Links for TM9SF3 Gene

GeneLoc Exon Structure for
TM9SF3
ECgene alternative splicing isoforms for
TM9SF3

Expression for TM9SF3 Gene

mRNA expression in normal human tissues for TM9SF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TM9SF3 Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM9SF3 Gene



SOURCE GeneReport for Unigene cluster for TM9SF3 Gene Hs.500674

genes like me logo Genes that share expression patterns with TM9SF3: view

Protein tissue co-expression partners for TM9SF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TM9SF3 Gene

Orthologs for TM9SF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TM9SF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM9SF3 36
  • 100 (a)
OneToOne
TM9SF3 35
  • 99.82 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TM9SF3 36
  • 99 (a)
OneToOne
TM9SF3 35
  • 95.91 (n)
  • 99.49 (a)
dog
(Canis familiaris)
Mammalia TM9SF3 35
  • 95.8 (n)
  • 99.32 (a)
TM9SF3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tm9sf3 16
Tm9sf3 36
  • 99 (a)
OneToOne
Tm9sf3 35
  • 92.22 (n)
  • 99.15 (a)
oppossum
(Monodelphis domestica)
Mammalia TM9SF3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TM9SF3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tm9sf3 35
  • 92.67 (n)
  • 99.15 (a)
chicken
(Gallus gallus)
Aves TM9SF3 36
  • 94 (a)
OneToOne
TM9SF3 35
  • 86.43 (n)
  • 98.56 (a)
lizard
(Anolis carolinensis)
Reptilia TM9SF3 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12856 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6006 35
tm9sf3 35
  • 83.45 (n)
  • 97.7 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.26978 35
tm9sf3 35
  • 80.4 (n)
  • 96.09 (a)
tm9sf3 36
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004882 35
  • 67.93 (n)
  • 77.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10590 36
  • 72 (a)
OneToOne
CG10590 35
  • 65.84 (n)
  • 75.18 (a)
worm
(Caenorhabditis elegans)
Secernentea Y41D4A.4 36
  • 64 (a)
OneToOne
Y41D4A.4 35
  • 63.59 (n)
  • 70.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP70 36
  • 25 (a)
ManyToMany
TMN2 36
  • 24 (a)
ManyToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3627 35
soybean
(Glycine max)
eudicotyledons Gma.5446 35
thale cress
(Arabidopsis thaliana)
eudicotyledons TMN1 35
  • 60.57 (n)
  • 55.95 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4691 35
corn
(Zea mays)
Liliopsida Zm.4030 35
rice
(Oryza sativa)
Liliopsida Os12g0175700 35
  • 60.18 (n)
  • 57.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4192 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9350 36
  • 76 (a)
OneToOne
Species with no ortholog for TM9SF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TM9SF3 Gene

ENSEMBL:
Gene Tree for TM9SF3 (if available)
TreeFam:
Gene Tree for TM9SF3 (if available)

Paralogs for TM9SF3 Gene

Paralogs for TM9SF3 Gene

(4) SIMAP similar genes for TM9SF3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TM9SF3: view

Variants for TM9SF3 Gene

Sequence variations from dbSNP and Humsavar for TM9SF3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs3689 -- 96,518,358(+) GACAG(C/T)TGAAA utr-variant-3-prime
rs9093 -- 96,519,296(-) GAGAG(C/T)GGATG utr-variant-3-prime
rs1044022 -- 96,520,127(-) TTTAA(A/C)ATACC utr-variant-3-prime
rs1044029 -- 96,519,066(-) CTACA(C/T)ACCGA utr-variant-3-prime
rs1156035 -- 96,525,564(-) AAAGC(G/T)AAGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM9SF3 Gene

Variant ID Type Subtype PubMed ID
nsv825530 CNV Loss 20364138
esv1534879 CNV Insertion 17803354
nsv509363 CNV Insertion 20534489

Variation tolerance for TM9SF3 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM9SF3 Gene

HapMap Linkage Disequilibrium report
TM9SF3
Human Gene Mutation Database (HGMD)
TM9SF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM9SF3 Gene

Disorders for TM9SF3 Gene

Relevant External Links for TM9SF3

Genetic Association Database (GAD)
TM9SF3
Human Genome Epidemiology (HuGE) Navigator
TM9SF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TM9SF3

No disorders were found for TM9SF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM9SF3 Gene

Publications for TM9SF3 Gene

  1. The iodocyanopindolol and SM-11044 binding protein belongs to the TM9SF multispanning membrane protein superfamily. (PMID: 11595169) Sugasawa T. … Nahmias C. (Gene 2001) 2 3 23 67
  2. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  3. Identification of novel transmembrane proteins in scirrhous-type gastric cancer by the Escherichia coli ampicillin secretion trap (CAST) method: TM9SF3 participates in tumor invasion and serves as a prognostic factor. (PMID: 24642718) Oo H.Z. … Yasui W. (Pathobiology 2014) 3
  4. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PMID: 23798571) Roy S.J. … Parent J.L. (Mol. Endocrinol. 2013) 3
  5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 3

Products for TM9SF3 Gene

Sources for TM9SF3 Gene

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