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Aliases for TM9SF3 Gene

Aliases for TM9SF3 Gene

  • Transmembrane 9 Superfamily Member 3 2 3
  • SM-11044-Binding Protein 3 4
  • EP70-P-Iso 3 4
  • SMBP 3 4
  • Dinucleotide Oxidase Disulfide Thiol Exchanger 3 Superfamily Member 3 3
  • Endomembrane Protein Emp70 Precursor Isolog 3
  • SM-11044 Binding Protein 3

External Ids for TM9SF3 Gene

Previous GeneCards Identifiers for TM9SF3 Gene

  • GC10M098267
  • GC10M091907

Summaries for TM9SF3 Gene

GeneCards Summary for TM9SF3 Gene

TM9SF3 (Transmembrane 9 Superfamily Member 3) is a Protein Coding gene. An important paralog of this gene is TM9SF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM9SF3 Gene

Genomics for TM9SF3 Gene

Regulatory Elements for TM9SF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TM9SF3 Gene

96,518,109 bp from pter
96,587,452 bp from pter
69,344 bases
Minus strand

Genomic View for TM9SF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TM9SF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM9SF3 Gene

Proteins for TM9SF3 Gene

  • Protein details for TM9SF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 9 superfamily member 3
    Protein Accession:
    Secondary Accessions:
    • Q5TB57
    • Q6UWE7
    • Q9NWL8
    • Q9P0G9
    • Q9UHW8

    Protein attributes for TM9SF3 Gene

    589 amino acids
    Molecular mass:
    67888 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF67014.1; Type=Frameshift; Positions=184, 198, 370, 446; Evidence={ECO:0000305}; Sequence=AAQ89178.1; Type=Frameshift; Positions=70; Evidence={ECO:0000305}; Sequence=BAA91362.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TM9SF3 Gene

Proteomics data for TM9SF3 Gene at MOPED

Post-translational modifications for TM9SF3 Gene

  • Ubiquitination at Lys59 and Lys210
  • Glycosylation at Asn174 and Asn419
  • Modification sites at PhosphoSitePlus

Other Protein References for TM9SF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TM9SF3 Gene

Domains for TM9SF3 Gene

Protein Domains for TM9SF3 Gene


Suggested Antigen Peptide Sequences for TM9SF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9HD45
  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
genes like me logo Genes that share domains with TM9SF3: view

No data available for Gene Families for TM9SF3 Gene

Function for TM9SF3 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM9SF3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TM9SF3 Gene

Localization for TM9SF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM9SF3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM9SF3 Gene COMPARTMENTS Subcellular localization image for TM9SF3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TM9SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM9SF3: view

Pathways for TM9SF3 Gene

SuperPathways for TM9SF3 Gene

No Data Available

Interacting Proteins for TM9SF3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000360184 Q9HD45-TM9S3_HUMAN for TM9SF3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TM9SF3 Gene


No data available for Pathways by source for TM9SF3 Gene

Transcripts for TM9SF3 Gene

Unigene Clusters for TM9SF3 Gene

Transmembrane 9 superfamily member 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM9SF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF3 Gene

No ASD Table

Relevant External Links for TM9SF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM9SF3 Gene

mRNA expression in normal human tissues for TM9SF3 Gene

Protein differential expression in normal tissues for TM9SF3 Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM9SF3 Gene

SOURCE GeneReport for Unigene cluster for TM9SF3 Gene Hs.500674

genes like me logo Genes that share expressions with TM9SF3: view

Expression partners for TM9SF3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TM9SF3 Gene

Orthologs for TM9SF3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TM9SF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM9SF3 35
  • 95.91 (n)
  • 99.49 (a)
TM9SF3 36
  • 99 (a)
(Canis familiaris)
Mammalia TM9SF3 35
  • 95.8 (n)
  • 99.32 (a)
TM9SF3 36
  • 99 (a)
(Mus musculus)
Mammalia Tm9sf3 35
  • 92.22 (n)
  • 99.15 (a)
Tm9sf3 16
Tm9sf3 36
  • 99 (a)
(Pan troglodytes)
Mammalia TM9SF3 35
  • 99.82 (n)
  • 100 (a)
TM9SF3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tm9sf3 35
  • 92.67 (n)
  • 99.15 (a)
(Monodelphis domestica)
Mammalia TM9SF3 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia TM9SF3 36
  • 95 (a)
(Gallus gallus)
Aves TM9SF3 35
  • 86.43 (n)
  • 98.56 (a)
TM9SF3 36
  • 94 (a)
(Anolis carolinensis)
Reptilia TM9SF3 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6006 35
tm9sf3 35
  • 83.45 (n)
  • 97.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12856 35
(Danio rerio)
Actinopterygii Dr.26978 35
tm9sf3 35
  • 80.4 (n)
  • 96.09 (a)
tm9sf3 36
  • 92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004882 35
  • 67.93 (n)
  • 77.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10590 35
  • 65.84 (n)
  • 75.18 (a)
CG10590 36
  • 72 (a)
(Caenorhabditis elegans)
Secernentea Y41D4A.4 35
  • 63.59 (n)
  • 70.52 (a)
Y41D4A.4 36
  • 64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP70 36
  • 25 (a)
TMN2 36
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TMN1 35
  • 60.57 (n)
  • 55.95 (a)
(Glycine max)
eudicotyledons Gma.5446 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3627 35
(Hordeum vulgare)
Liliopsida Hv.4691 35
(Oryza sativa)
Liliopsida Os12g0175700 35
  • 60.18 (n)
  • 57.17 (a)
(Zea mays)
Liliopsida Zm.4030 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4192 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9350 36
  • 76 (a)
Species with no ortholog for TM9SF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TM9SF3 Gene

Gene Tree for TM9SF3 (if available)
Gene Tree for TM9SF3 (if available)

Paralogs for TM9SF3 Gene

Paralogs for TM9SF3 Gene

Selected SIMAP similar genes for TM9SF3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TM9SF3: view

Variants for TM9SF3 Gene

Sequence variations from dbSNP and Humsavar for TM9SF3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3689 -- 96,518,358(+) GACAG(C/T)TGAAA utr-variant-3-prime
rs9093 -- 96,519,296(-) GAGAG(C/T)GGATG utr-variant-3-prime
rs10762 -- 96,521,971(-) GACCA(G/T)CTCTC utr-variant-3-prime
rs713251 -- 96,528,309(+) AACAG(C/T)TTCTC intron-variant
rs1018604 -- 96,581,826(-) GTTTA(C/G)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM9SF3 Gene

Variant ID Type Subtype PubMed ID
nsv825530 CNV Loss 20364138
esv1534879 CNV Insertion 17803354
nsv509363 CNV Insertion 20534489

Relevant External Links for TM9SF3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM9SF3 Gene

Disorders for TM9SF3 Gene

Relevant External Links for TM9SF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TM9SF3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TM9SF3 Gene

Publications for TM9SF3 Gene

  1. The iodocyanopindolol and SM-11044 binding protein belongs to the TM9SF multispanning membrane protein superfamily. (PMID: 11595169) Sugasawa T. … Nahmias C. (Gene 2001) 2 3 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TM9SF3 Gene

Sources for TM9SF3 Gene

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