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TM9SF2 Gene

protein-coding   GIFtS: 55
GCID: GC13P100153

Transmembrane 9 Superfamily Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane 9 Superfamily Member 21 2
76 KDa Membrane Protein2
P762
Dinucleotide Oxidase Disulfide Thiol Exchanger 3 Superfamily Member 22
Transmembrane Protein 9 Superfamily Member 22
p763

External Ids:    HGNC: 118651   Entrez Gene: 93752   Ensembl: ENSG000001253047   OMIM: 6046785   UniProtKB: Q998053   

Export aliases for TM9SF2 gene to outside databases

Previous GC identifers: GC13P098513 GC13P094540 GC13P098990 GC13P097851 GC13P098951 GC13P080748


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TM9SF2 Gene:
This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early
endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain
which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an
ion channel. A pseudogene associated with this gene is located on the X chromosome. (provided by RefSeq, Oct
2012)

GeneCards Summary for TM9SF2 Gene:
TM9SF2 (transmembrane 9 superfamily member 2) is a protein-coding gene. An important paralog of this gene is TM9SF3.

UniProtKB/Swiss-Prot: TM9S2_HUMAN, Q99805
Function: In the intracellular compartments, may function as a channel or small molecule transporter

Gene Wiki entry for TM9SF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TM9SF2 gene promoter:
         STAT5B   STAT1   Nkx2-2   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTM9SF2 promoter sequence
   Search Chromatin IP Primers for TM9SF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TM9SF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.2

TM9SF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TM9SF2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P100153:  view genomic region     (about GC identifiers)

Start:
100,153,671 bp from pter      End:
100,216,260 bp from pter
Size:
62,590 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TM9S2_HUMAN, Q99805 (See protein sequence)
Recommended Name: Transmembrane 9 superfamily member 2 precursor  
Size: 663 amino acids; 75776 Da
Secondary accessions: A8K399 Q2TAY5

Explore the universe of human proteins at neXtProt for TM9SF2: NX_Q99805

Explore proteomics data for TM9SF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TM9SF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004791.1  
    ENSEMBL proteins: 
     ENSP00000365567  

    TM9SF2 Human Recombinant Protein Products:

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    antibodies-online proteins for TM9SF2 (2 products) 

     
    antibodies-online peptides for TM9SF2

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    antibodies-online antibodies for TM9SF2 (10 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004240 EMP70

    Graphical View of Domain Structure for InterPro Entry Q99805

    ProtoNet protein and cluster: Q99805

    1 Blocks protein domain: IPB004240 Nonaspanin (TM9SF)

    UniProtKB/Swiss-Prot: TM9S2_HUMAN, Q99805
    Similarity: Belongs to the nonaspanin (TM9SF) family


    Find genes that share domains with TM9SF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM9S2_HUMAN, Q99805
    Function: In the intracellular compartments, may function as a channel or small molecule transporter

    Phenotypes:
         1 GenomeRNAi human phenotype for TM9SF2:

     Decreased p24 protein expressi 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TM9SF2

    miRNA
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    miRTarBase miRNAs that target TM9SF2:
    hsa-mir-615-3p (MIRT040243)

    Block miRNA regulation of human, mouse, rat TM9SF2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TM9SF2:
    hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidTM9SF2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TM9SF2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM9S2_HUMAN, Q99805: Endosome membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane4
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome TAS9729438
    GO:0005887integral component of plasma membrane TAS9729438
    GO:0010008endosome membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0070062extracellular vesicular exosome IDA19199708

    Find genes that share ontologies with TM9SF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TM9SF2
    Interactions:

        Search GeneGlobe Interaction Network for TM9SF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TM9SF2 (Q998052, 3 ENSP000003655674) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134852, 3, ENSP000003415514MINT-61975 I2D: score=3 STRING: ENSP00000341551
    RAB9AP511513, ENSP000004201274I2D: score=2 STRING: ENSP00000420127
    UNC93B1Q9H1C43, ENSP000002274714I2D: score=1 STRING: ENSP00000227471
    SNX8ENSP000002229904STRING: ENSP00000222990
    SIGMAR1ENSP000002770104STRING: ENSP00000277010
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS9729438

    Find genes that share ontologies with TM9SF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TM9SF2 (TM9S2)

    2 Novoseek inferred chemical compound relationships for TM9SF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 6-phosphate 61.4 2 17105447 (1), 9729438 (1)
    tyrosine 27.9 2 7678053 (1)



    Find genes that share compounds with TM9SF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TM9SF2 gene: 
    NM_004800.2  

    Unigene Cluster for TM9SF2:

    Transmembrane 9 superfamily member 2
    Hs.607896  [show with all ESTs]
    Unigene Representative Sequence: NM_004800
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376387(uc001voj.1 uc010afz.1) ENST00000463709 ENST00000466555

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate TM9SF2:
    hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidTM9SF2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TM9SF2
    Predesigned siRNA for gene silencing in human, mouse, rat TM9SF2
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    GenScript: all cDNA clones in your preferred vector: TM9SF2 (NM_004800)
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      QuantiTect SYBR Green Assays in human, mouse, rat TM9SF2
      QuantiFast Probe-based Assays in human, mouse, rat TM9SF2

    Additional mRNA sequence: 

    AK093507.1 AK129798.1 AK225800.1 AK290514.1 AK315210.1 BC110656.1 BC130293.1 L13803.1 
    U81006.1 

    Selected DOTS entries (see all 25):

    DT.95112729  DT.317194  DT.95372525  DT.120765865  DT.40310184  DT.100824973  DT.120765841  DT.95372531 
    DT.120765845  DT.120765888  DT.86840568  DT.95303455  DT.100771316  DT.120765851  DT.120765839  DT.40314711 
    DT.92005039  DT.120765853  DT.95164546  DT.95372529  DT.97817484  DT.120705076  DT.92005498  DT.95086936 

    Selected AceView cDNA sequences (see all 499):

    BM354119 AU132869 AU131084 BP364101 BG563963 BG621719 CB128663 BM837335 
    BU753639 BG529112 AA318629 CK299887 H24022 L13803 BX956407 AA916421 
    T93767 AA774632 BX956364 AW261915 AA736880 AW589458 BF970014 BG567626 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
    SP1:              -                                                                 -                             -               
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for TM9SF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TM9SF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTGGCCT
    TM9SF2 Expression
    About this image


    TM9SF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TM9SF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TM9SF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.607896

    UniProtKB/Swiss-Prot: TM9S2_HUMAN, Q99805
    Tissue specificity: Ubiquitously expressed. Especially abundant in pancreas, highly expressed in kidney, lower
    levels in heart, brain, skeletal muscle and placenta. Lowest expression in lung and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TM9SF2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tm9sf21 , 5 transmembrane 9 superfamily member 21, 5 90.13(n)1
    95.77(a)1
      14 (65.86 cM)5
    680591  NM_080556.31  NP_542123.31 
     1221070385 
    chicken
    (Gallus gallus)
    Aves TM9SF21 transmembrane 9 superfamily member 2 82.12(n)
    93.06(a)
      418777  XM_416972.4  XP_416972.1 
    lizard
    (Anolis carolinensis)
    Reptilia TM9SF26
    transmembrane 9 superfamily member 2
    89(a)
    1 ↔ 1
    3(98895605-98929991)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162762 Xenopus laevis cDNA clone IMAGE4724777, partial cds 81.43(n)    BC057725.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi20b052 Danio rerio mRNA similar to transmembrane 9 superfamily more 75.1(n)    BC049137.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93183   -- 68(a)   38E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea F08F1.73
    tag-1231
    tag-1231 62(a)3
    62.1(n)1
    63.69(a)1
      X(8454354-8457295)3
    1810961  NM_077028.51  NP_509429.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes EMP706
    TMN26
    Protein with a role in cellular adhesion, filament...
    Protein with a role in cellular adhesion and filam...
    36(a)
    34(a)
    many ↔ many
    many ↔ many
    XII(294091-296094) YLR083C
    IV(669016-671034) YDR107C
    soybean
    (Glycine max)
    eudicotyledons BQ610989.12   -- 74.44(n)    BQ610989.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.96322 Triticum aestivum transcribed sequence with moderate more 73.97(n)    CK206525.1 


    ENSEMBL Gene Tree for TM9SF2 (if available)
    TreeFam Gene Tree for TM9SF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TM9SF2 gene
    TM9SF32  ENSG000002546922  ENSG000002595222  TM9SF42  TM9SF12  
    4 SIMAP similar genes for TM9SF2 using alignment to 1 protein entry:     TM9S2_HUMAN:
    TM9SF4    SMBP    TM9SF3    TM9SF1

    Find genes that share paralogs with TM9SF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TM9SF2
    PGOHUM00000242042


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TM9SF2 (see all 1345)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741122521,2
    C,F--100151754(+) TAGGTT/CCTTCT 1 -- us2k12Minor allele frequency- C:0.08WA 120
    rs73185491,2
    C,F,A,H--100151812(+) aaaacT/Agggag 1 -- us2k17Minor allele frequency- A:0.07NS EA WA CSA 540
    rs1448706201,2
    C--100151862(+) GTCAA-/GTTT  
     TTTTTTT
    GTTTT
    1 -- us2k10--------
    rs118423881,2
    C,A,H--100151873(+) TTTTTT/GTTTTT 1 -- us2k12Minor allele frequency- G:0.00NA CSA 3
    rs1421240891,2
    C--100151873(+) TTTTT-/GTTTTT 1 -- us2k10--------
    rs714334401,2
    C--100151881(+) TTTTTG/TTTTTT 1 -- us2k12Minor allele frequency- T:0.25NA 4
    rs711184831,2
    C--100151884(-) AAAAA-/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs73187151,2
    C,A--100151885(+) tttttG/Tttttt 1 -- us2k1 trp30--------
    rs1389491721,2
    C--100151944(+) ATCTCA/GGCTTA 1 -- us2k10--------
    rs342822551,2
    C--100151964(+) CCGCC-/TCCCGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TM9SF2 (100153671 - 100216260 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TM9SF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34003CNV Loss18971310
    nsv510934CNV Complex20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TM9SF2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604678    OMIM disorders: --


    Find genes that share disorders with TM9SF2           About GenesLikeMe

    Genetic Association Database (GAD): TM9SF2
    Human Genome Epidemiology (HuGE) Navigator: TM9SF2 (2 documents)

    Export disorders for TM9SF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TM9SF2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with TM9SF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a 76 kDa endosomal, multispanning membrane protein that is highly conserved throughout evolution. (PubMed id 9729438)1, 2, 3, 9 Schimmoeller F.... Pfeffer S.R. (Gene 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9375 HGNC: 11865 AceView: TM9SF2 Ensembl:ENSG00000125304 euGenes: HUgn9375
    ECgene: TM9SF2 H-InvDB: TM9SF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TM9SF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TM9SF2 gene:
    Search GeneIP for patents involving TM9SF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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