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Aliases for TM9SF1 Gene

Aliases for TM9SF1 Gene

  • Transmembrane 9 Superfamily Member 1 2 3
  • MP70 Protein Family Member 3 4
  • HMP70 3 4
  • Transmembrane Protein 9 Superfamily Member 1 3
  • Multispanning Membrane Protein (70kD) 3
  • MP70 3

External Ids for TM9SF1 Gene

Previous GeneCards Identifiers for TM9SF1 Gene

  • GC14M022030
  • GC14M018445
  • GC14M022648
  • GC14M023728
  • GC14M024658
  • GC14M004773

Summaries for TM9SF1 Gene

GeneCards Summary for TM9SF1 Gene

TM9SF1 (Transmembrane 9 Superfamily Member 1) is a Protein Coding gene. An important paralog of this gene is TM9SF2.

UniProtKB/Swiss-Prot for TM9SF1 Gene

  • Plays an essential role in autophagy.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM9SF1 Gene

Genomics for TM9SF1 Gene

Regulatory Elements for TM9SF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TM9SF1 Gene

24,189,143 bp from pter
24,195,736 bp from pter
6,594 bases
Minus strand

Genomic View for TM9SF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TM9SF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM9SF1 Gene

Proteins for TM9SF1 Gene

  • Protein details for TM9SF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 9 superfamily member 1
    Protein Accession:
    Secondary Accessions:
    • D3DS65
    • Q86SZ6
    • Q96FI8

    Protein attributes for TM9SF1 Gene

    606 amino acids
    Molecular mass:
    68861 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM9SF1 Gene


neXtProt entry for TM9SF1 Gene

Proteomics data for TM9SF1 Gene at MOPED

Post-translational modifications for TM9SF1 Gene

  • Glycosylation at Asn178, Asn401, and Asn559
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TM9SF1 Gene

Domains for TM9SF1 Gene

Protein Domains for TM9SF1 Gene


Suggested Antigen Peptide Sequences for TM9SF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O15321
  • Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
genes like me logo Genes that share domains with TM9SF1: view

No data available for Gene Families for TM9SF1 Gene

Function for TM9SF1 Gene

Molecular function for TM9SF1 Gene

GENATLAS Biochemistry:
transmembrane 9 superfamily,member 1,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Plays an essential role in autophagy.

Animal Model Products

miRNA for TM9SF1 Gene

miRTarBase miRNAs that target TM9SF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM9SF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TM9SF1 Gene

Localization for TM9SF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM9SF1 Gene

Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM9SF1 Gene COMPARTMENTS Subcellular localization image for TM9SF1 gene
Compartment Confidence
lysosome 5
vacuole 5
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TM9SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagic vacuole membrane IEA --
GO:0005764 lysosome --
GO:0005765 lysosomal membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TM9SF1: view

Pathways for TM9SF1 Gene

SuperPathways for TM9SF1 Gene

No Data Available

Interacting Proteins for TM9SF1 Gene

Gene Ontology (GO) - Biological Process for TM9SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with TM9SF1: view

No data available for Pathways by source for TM9SF1 Gene

Transcripts for TM9SF1 Gene

Unigene Clusters for TM9SF1 Gene

Transmembrane 9 superfamily member 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM9SF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c
SP1: - - -
SP2: - - - - - - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: -
SP7: -
SP8: - - - -
SP9: -
SP10: - -

Relevant External Links for TM9SF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM9SF1 Gene

mRNA expression in normal human tissues for TM9SF1 Gene

Protein differential expression in normal tissues for TM9SF1 Gene

This gene is overexpressed in Nasal epithelium (46.9) and Breast (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TM9SF1 Gene

SOURCE GeneReport for Unigene cluster for TM9SF1 Gene Hs.91586

mRNA Expression by UniProt/SwissProt for TM9SF1 Gene

Tissue specificity: Expressed in lung, pancreas, kidney, liver, placenta, skeletal muscle, heart and brain. The amount in skeletal muscle, heart and brain were considerably lower than in the other tissues.
genes like me logo Genes that share expressions with TM9SF1: view

Expression partners for TM9SF1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TM9SF1 Gene

Orthologs for TM9SF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TM9SF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM9SF1 35
  • 94.06 (n)
  • 97.52 (a)
-- 36
  • 98 (a)
(Canis familiaris)
Mammalia TM9SF1 35
  • 94.17 (n)
  • 98.51 (a)
-- 36
  • 73 (a)
(Mus musculus)
Mammalia Tm9sf1 35
  • 92.96 (n)
  • 97.52 (a)
Tm9sf1 16
Tm9sf1 36
  • 98 (a)
(Pan troglodytes)
Mammalia TM9SF1 35
  • 99.72 (n)
  • 100 (a)
-- 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Tm9sf1 35
  • 92.64 (n)
  • 96.94 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm9sf1 35
  • 71.6 (n)
  • 82.04 (a)
(Danio rerio)
Actinopterygii tm9sf1 35
  • 70.49 (n)
  • 76.01 (a)
tm9sf1 36
  • 72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10722 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMP70 36
  • 27 (a)
TMN2 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G01970 35
  • 53.8 (n)
  • 49.29 (a)
(Oryza sativa)
Liliopsida Os.47365 35
Os03g0237000 35
  • 53.74 (n)
  • 48.1 (a)
(Zea mays)
Liliopsida Zm.17591 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4226 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
Species with no ortholog for TM9SF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM9SF1 Gene

Gene Tree for TM9SF1 (if available)
Gene Tree for TM9SF1 (if available)

Paralogs for TM9SF1 Gene

Paralogs for TM9SF1 Gene

genes like me logo Genes that share paralogs with TM9SF1: view

Variants for TM9SF1 Gene

Sequence variations from dbSNP and Humsavar for TM9SF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs10583 - 24,192,971(-) GGAGC(A/G)TCGGA missense, reference
rs1061838 -- 24,191,200(-) ACCGG(C/G)TTGGG intron-variant
rs1242032 -- 24,197,576(-) tttca(C/T)catgt upstream-variant-2KB
rs1242033 -- 24,196,855(-) cgcct(C/T)ggcct upstream-variant-2KB
rs2234095 -- 24,195,873(-) CGAGC(C/G)GCCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TM9SF1 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294
nsv1220 CNV Insertion 18451855

Relevant External Links for TM9SF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM9SF1 Gene

Disorders for TM9SF1 Gene

No disorders were found for TM9SF1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TM9SF1 Gene

Publications for TM9SF1 Gene

  1. Cloning of a human multispanning membrane protein cDNA: evidence for a new protein family. (PMID: 9332367) Chluba-de Tapia J. … Eberle A.N. (Gene 1997) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene. (PMID: 19029833) He P. … Ma D. (Autophagy 2009) 3 4
  4. ErbB2-associated changes in the lysosomal proteome. (PMID: 21674799) Nylandsted J. … JAoAottelAo M. (Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for TM9SF1 Gene

Sources for TM9SF1 Gene

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