TM9SF1 Gene
protein-coding GIFtS: 48
GCID: GC14M024658
|
|
transmembrane 9 superfamily member 1
| |
Aliases
for TM9SF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane 9 Superfamily Member 11 2 | | Multispanning Membrane Protein (70kD)2 | | HMP701 2 | | Transmembrane Protein 9 Superfamily Member 12 | | MP701 2 | | HMP701 2 | | MP70 Protein Family Member2 3 | | |
Export aliases for TM9SF1 gene to outside databasesPrevious GC identifers: GC14M022030 GC14M018445 GC14M022648 GC14M023728 GC14M004773 |
Summaries
for TM9SF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM9S1_HUMAN, O15321Function: Plays an essential role in autophagy
|
Genomic Views
for TM9SF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TM9SF1 gene promoter:
RFX1 Lmo2 RelA Nkx2-5 Nkx5-1 c-Ets-1 GATA-1 PPAR-gamma1 PPAR-gamma2 NF-E2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TM9SF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM9SF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q12 HGNC cytogenetic band: 14q11.2TM9SF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M024658: view genomic region
(about GC identifiers)
Start:
|
24,658,349 bp from pter |
End:
|
24,682,679 bp from pter |
Size:
|
24,331 bases |
Orientation:
|
minus strand |
|
Proteins
for TM9SF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM9S1_HUMAN, O15321 (See
protein sequence)Recommended Name: Transmembrane 9 superfamily member 1 precursor Size: 606 amino acids; 68861 Da
Subcellular location: Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane;Multi-pass membrane protein
Secondary accessions: D3DS65 Q86SZ6 Q96FI8Alternative splicing: 2 isoforms: O15321-1 O15321-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TM9SF1: NX_O15321
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15321
TM9SF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001014842.1 NP_006396.2
ENSEMBL proteins: ENSP00000261789 ENSP00000432997 ENSP00000431747 ENSP00000434387 ENSP00000436486 ENSP00000380063 ENSP00000431447 ENSP00000437127 ENSP00000435857 ENSP00000432435 ENSP00000433792 ENSP00000451949
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TM9SF1 for ontologies About GeneDecksing
TM9SF1 Antibody Products:
Assay Products for TM9SF1: |
Protein
Domains /
Families
for TM9SF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TM9SF1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O15321ProtoNet protein and cluster: O15321 1 Blocks protein family: IPB004240 Nonaspanin (TM9SF)
UniProtKB/Swiss-Prot: TM9S1_HUMAN, O15321Similarity: Belongs to the nonaspanin (TM9SF) family |
Function
for TM9SF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM9S1_HUMAN, O15321Function: Plays an essential role in autophagy Genatlas biochemistry entry for TM9SF1:transmembrane 9 superfamily,member 1,ubiquitously expressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF1 |
|
Pathways & Interactions
for TM9SF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TM9SF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for TM9SF1 (O153213 ENSP000002617894) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TM9SF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TM9SF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TM9SF1
Search CenterWatch for drugs/clinical trials and news about TM9SF1 / TM9S1
|
Transcripts
for TM9SF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TM9SF1 gene (2 alternative transcripts): NM_001014842.1 NM_006405.5 Unigene Cluster for TM9SF1: Transmembrane 9 superfamily member 1 Hs.91586 [show with all ESTs]Unigene Representative Sequence: NM_00640513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261789(uc010toa.1 uc001wnb.1) ENST00000528669 ENST00000529332
ENST00000524835 ENST00000532632 ENST00000396854(uc001wnc.3) ENST00000531406
ENST00000528895 ENST00000530563 ENST00000530468 ENST00000525592 ENST00000528010
ENST00000556387
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM9SF1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TM9SF1 (NM_006405) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK292110.1 AK304642.1 BC010856.2 BX161390.1 BX161494.1 U94831.1 20 DOTS entries: DT.316366 DT.100858196 DT.100858198 DT.101984522 DT.100858200 DT.100858188 DT.316365 DT.100723743 DT.95190065 DT.120755398 DT.95094529 DT.100770753 DT.316368 DT.99951905 DT.100858189 DT.100772236 DT.100858191 DT.95210591 DT.99999972 DT.86997836 24/647 AceView cDNA sequences (see all 647): BQ221987 BU158214 AW438684 BX339718 AA385530 AA127785 BQ220620 CD109375 CB306204 AL708546 BU170173 BF108797 BI087419 BM822660 NM_006405 AW296244 BQ222839 BQ227526 BM548775 BF001674 AW573223 BM047035 CB148699 BE408797
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TM9SF1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TM9SF1
|
Expression
for TM9SF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TM9SF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGTTGAA
About this image
See TM9SF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TM9SF1
SOURCE GeneReport for Unigene cluster: Hs.91586
UniProtKB/Swiss-Prot: TM9S1_HUMAN, O15321Tissue specificity: Expressed in lung, pancreas, kidney, liver, placenta, skeletal muscle, heart and brain. The amountin skeletal muscle, heart and brain were considerably lower than in the other tissues
SABiosciences Custom PCR Arrays for TM9SF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM9SF1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF1 |
Orthologs
for TM9SF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TM9SF1 gene from 5/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
86(a) |
1 → many |
GL343400.1(56804-61579) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480506642 |
-- |
77.03(n) |
|
48050664 |
zebrafish
(Danio rerio) |
Actinopterygii |
tm9sf11 |
transmembrane 9 superfamily member 1 |
70.8(n)
76.81(a) |
|
445156 NM_001003550.1 NP_001003550.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G019701 |
putative endomembrane protein 70 |
54.5(n)
50.27(a) |
|
814728 NM_126258.2 NP_178306.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.473652 |
Oryza sativa (japonica cultivar-group) putative Transmembrane more |
80.58(n) |
|
NM_189098.1 |
ENSEMBL Gene Tree for TM9SF1 (if available)
TreeFam Gene Tree for TM9SF1 (if available) |
Paralogs
for TM9SF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TM9SF1 gene
- TM9SF32 ENSG000002546922 ENSG000002595222 TM9SF22 TM9SF42
8 SIMAP similar genes for TM9SF1 using alignment to 11 protein entries: TM9S1_HUMAN (see all proteins):CHMP4A CHMP4B CHMP4C SMBP TM9SF3 CHMP6
TM9SF4 TM9SF2
TM9SF1 for paralogs About GeneDecksing
|
Genomic Variants
for TM9SF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TM9SF1 (24658349 - 24682679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TM9SF1
1 CNV: 35245 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM9SF1 |
|
Disorders
/ Diseases
for TM9SF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TM9SF1 for disorders About GeneDecksing
1  disease for TM9SF1: About MalaCardsmalaria
Export disorders for TM9SF1 gene to outside databases
|
Publications
for TM9SF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TM9SF1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TM9SF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a human multispanning membrane protein cDNA: evidence for a new protein family. (PubMed id 9332367)1, 2, 3, 9 Chluba-de Tapia J.... Eberle A.N. (1997)
- High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene. (PubMed id 19029833)1, 2 He P.... Ma D. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- ErbB2-associated changes in the lysosomal proteome. (PubMed id 21674799)1 Nylandsted J....Jaattela M. (2011)
- HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells. (PubMed id 17342744)1 Dall'Era M.A....Liu A.Y. (2007)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The iodocyanopindolol and SM-11044 binding protein belongs to the TM9SF multispanning membrane protein superfamily. (PubMed id 11595169)1 Sugasawa T....Nahmias C. (2001)
|
External Searches for TM9SF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TM9SF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TM9SF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TM9SF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TM9SF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TM9SF1 gene:
Search GeneIP for patents involving TM9SF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TM9SF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
 |
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 |
 | | | TM9SF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM9SF1 |
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