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Aliases for TM7SF3 Gene

Aliases for TM7SF3 Gene

  • Transmembrane 7 Superfamily Member 3 2 3 5
  • Seven Span Transmembrane Protein 4

External Ids for TM7SF3 Gene

Previous GeneCards Identifiers for TM7SF3 Gene

  • GC12M027486
  • GC12M027137
  • GC12M027026
  • GC12M027017
  • GC12M027124
  • GC12M026894

Summaries for TM7SF3 Gene

GeneCards Summary for TM7SF3 Gene

TM7SF3 (Transmembrane 7 Superfamily Member 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TM7SF3 Gene

  • Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).

Additional gene information for TM7SF3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM7SF3 Gene

Genomics for TM7SF3 Gene

GeneHancer (GH) Regulatory Elements for TM7SF3 Gene

Promoters and enhancers for TM7SF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I027011 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.3 264 4.4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF213 TM7SF3 ENSG00000247903 MED21 C12orf71
GH12I027330 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -319.7 -319651 7.4 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZNF48 GLIS2 ZNF416 ZNF207 ARNTL2 STK38L TM7SF3 MED21 HMGB1P49 FGFR1OP2 GC12P027317 ARNTL2-AS1
GH12I026935 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.8 +75.1 75139 8.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B INTS13 FGFR1OP2 ENSG00000247903 TM7SF3 MED21 ITPR2 PIR61598
GH12I027242 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.5 -230.3 -230335 4.5 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 POLR2B PIR41524 STK38L MED21 ENSG00000247903 TM7SF3 C12orf71 GC12P027317
GH12I026877 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15 +135.7 135683 1.7 CTCF USF1 MAX ZNF384 BMI1 RAD21 POLR2A HNF4G SMC3 RFX1 TM7SF3 ENSG00000247903 MED21 ITPR2 GC12M026907
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TM7SF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TM7SF3 gene promoter:

Genomic Locations for TM7SF3 Gene

Genomic Locations for TM7SF3 Gene
chr12:26,971,570-27,014,434
(GRCh38/hg38)
Size:
42,865 bases
Orientation:
Minus strand
chr12:27,124,503-27,167,367
(GRCh37/hg19)

Genomic View for TM7SF3 Gene

Genes around TM7SF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM7SF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM7SF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM7SF3 Gene

Proteins for TM7SF3 Gene

  • Protein details for TM7SF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS93-TM7S3_HUMAN
    Recommended name:
    Transmembrane 7 superfamily member 3
    Protein Accession:
    Q9NS93
    Secondary Accessions:
    • B3KMZ3
    • Q9NUS4

    Protein attributes for TM7SF3 Gene

    Size:
    570 amino acids
    Molecular mass:
    64166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM7SF3 Gene

Post-translational modifications for TM7SF3 Gene

  • Ubiquitination at posLast=213213, isoforms=553, and isoforms=558
  • Glycosylation at isoforms=27, posLast=6161, posLast=7575, posLast=8787, and isoforms=264

No data available for DME Specific Peptides for TM7SF3 Gene

Domains & Families for TM7SF3 Gene

Gene Families for TM7SF3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TM7SF3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TM7SF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TM7SF3: view

No data available for UniProtKB/Swiss-Prot for TM7SF3 Gene

Function for TM7SF3 Gene

Molecular function for TM7SF3 Gene

UniProtKB/Swiss-Prot Function:
Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).

Gene Ontology (GO) - Molecular Function for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TM7SF3: view
genes like me logo Genes that share phenotypes with TM7SF3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM7SF3 Gene

Localization for TM7SF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM7SF3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM7SF3 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 10828615
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with TM7SF3: view

Pathways & Interactions for TM7SF3 Gene

SuperPathways for TM7SF3 Gene

No Data Available

Interacting Proteins for TM7SF3 Gene

Selected Interacting proteins: Q9NS93-TM7S3_HUMAN for TM7SF3 Gene via IID

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032024 positive regulation of insulin secretion IMP 21853325
GO:0034620 cellular response to unfolded protein IMP 27740623
GO:0043069 negative regulation of programmed cell death IMP 21853325
genes like me logo Genes that share ontologies with TM7SF3: view

No data available for Pathways by source and SIGNOR curated interactions for TM7SF3 Gene

Drugs & Compounds for TM7SF3 Gene

No Compound Related Data Available

Transcripts for TM7SF3 Gene

Unigene Clusters for TM7SF3 Gene

Transmembrane 7 superfamily member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM7SF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - - - - - -
SP7:
SP8: - -
SP9: -
SP10: - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - -

Relevant External Links for TM7SF3 Gene

GeneLoc Exon Structure for
TM7SF3
ECgene alternative splicing isoforms for
TM7SF3

Expression for TM7SF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TM7SF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TM7SF3 Gene

This gene is overexpressed in Monocytes (27.3), Islet of Langerhans (18.7), Urine (10.6), and Pancreas (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TM7SF3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TM7SF3 Gene:

TM7SF3

SOURCE GeneReport for Unigene cluster for TM7SF3 Gene:

Hs.438641

mRNA Expression by UniProt/SwissProt for TM7SF3 Gene:

Q9NS93-TM7S3_HUMAN
Tissue specificity: Widely expressed. Highly expressed in kidney and pancreas.

Evidence on tissue expression from TISSUES for TM7SF3 Gene

  • Nervous system(3.8)
  • Blood(2.7)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with TM7SF3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TM7SF3 Gene

Orthologs for TM7SF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM7SF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM7SF3 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia TM7SF3 33 34
  • 87.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TM7SF3 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TM7SF3 33 34
  • 86.2 (n)
rat
(Rattus norvegicus)
Mammalia Tm7sf3 33
  • 79.35 (n)
mouse
(Mus musculus)
Mammalia Tm7sf3 33 16 34
  • 79.17 (n)
oppossum
(Monodelphis domestica)
Mammalia TM7SF3 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TM7SF3 33 34
  • 67.15 (n)
lizard
(Anolis carolinensis)
Reptilia TM7SF3 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18521 33
zebrafish
(Danio rerio)
Actinopterygii tm7sf3 33 34
  • 56.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012612 33
  • 39.68 (n)
Species where no ortholog for TM7SF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM7SF3 Gene

ENSEMBL:
Gene Tree for TM7SF3 (if available)
TreeFam:
Gene Tree for TM7SF3 (if available)

Paralogs for TM7SF3 Gene

No data available for Paralogs for TM7SF3 Gene

Variants for TM7SF3 Gene

Sequence variations from dbSNP and Humsavar for TM7SF3 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000030349 -- 26,978,378(-) T/C intron_variant
rs1000061396 -- 26,977,989(-) G/A intron_variant
rs1000081137 -- 27,000,668(-) C/T intron_variant
rs1000164507 -- 26,986,841(-) G/T intron_variant
rs1000278582 -- 26,980,071(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TM7SF3 Gene

Variant ID Type Subtype PubMed ID
esv2196642 CNV deletion 18987734
esv2509925 CNV deletion 19546169
esv2674997 CNV deletion 23128226
esv2745662 CNV deletion 23290073
esv3628924 CNV loss 21293372
esv3892164 CNV loss 25118596
esv3892165 CNV loss 25118596
nsv523964 CNV loss 19592680

Variation tolerance for TM7SF3 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TM7SF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TM7SF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM7SF3 Gene

Disorders for TM7SF3 Gene

Additional Disease Information for TM7SF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TM7SF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM7SF3 Gene

Publications for TM7SF3 Gene

  1. Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3. (PMID: 10828615) Akashi H … Nakamura Y (Cytogenetics and cell genetics 2000) 2 3 4 58
  2. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. (PMID: 27740623) Isaac R … Zick Y (Cell death and differentiation 2017) 3 4 58
  3. An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. (PMID: 21853325) Beck A … Zick Y (Diabetologia 2011) 3 4 58
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TM7SF3 Gene

Sources for TM7SF3 Gene

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