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Aliases for TM7SF3 Gene

Aliases for TM7SF3 Gene

  • Transmembrane 7 Superfamily Member 3 2 3 5
  • Seven Span Transmembrane Protein 4

External Ids for TM7SF3 Gene

Previous GeneCards Identifiers for TM7SF3 Gene

  • GC12M027486
  • GC12M027137
  • GC12M027026
  • GC12M027017
  • GC12M027124
  • GC12M026894

Summaries for TM7SF3 Gene

GeneCards Summary for TM7SF3 Gene

TM7SF3 (Transmembrane 7 Superfamily Member 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM7SF3 Gene

Genomics for TM7SF3 Gene

Regulatory Elements for TM7SF3 Gene

Promoters for TM7SF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TM7SF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM7SF3 Gene

Chromosome:
12
Start:
26,971,570 bp from pter
End:
27,014,434 bp from pter
Size:
42,865 bases
Orientation:
Minus strand

Genomic View for TM7SF3 Gene

Genes around TM7SF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM7SF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM7SF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM7SF3 Gene

Proteins for TM7SF3 Gene

  • Protein details for TM7SF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS93-TM7S3_HUMAN
    Recommended name:
    Transmembrane 7 superfamily member 3
    Protein Accession:
    Q9NS93
    Secondary Accessions:
    • B3KMZ3
    • Q9NUS4

    Protein attributes for TM7SF3 Gene

    Size:
    570 amino acids
    Molecular mass:
    64166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM7SF3 Gene

Proteomics data for TM7SF3 Gene at MOPED

Post-translational modifications for TM7SF3 Gene

  • Ubiquitination at Lys 213, Lys 553, and Lys 558
  • Glycosylation at Asn 27, Asn 61, Asn 75, Asn 87, and Asn 264
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TM7SF3 Gene

Domains & Families for TM7SF3 Gene

Protein Domains for TM7SF3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TM7SF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TM7SF3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TM7SF3 Gene

Function for TM7SF3 Gene

genes like me logo Genes that share phenotypes with TM7SF3: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM7SF3 Gene

Localization for TM7SF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM7SF3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TM7SF3 Gene COMPARTMENTS Subcellular localization image for TM7SF3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1

Gene Ontology (GO) - Cellular Components for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with TM7SF3: view

Pathways & Interactions for TM7SF3 Gene

SuperPathways for TM7SF3 Gene

No Data Available

Interacting Proteins for TM7SF3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342322%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000342322 Q9NS93-TM7S3_HUMAN for TM7SF3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TM7SF3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TM7SF3 Gene

Drugs & Compounds for TM7SF3 Gene

No Compound Related Data Available

Transcripts for TM7SF3 Gene

Unigene Clusters for TM7SF3 Gene

Transmembrane 7 superfamily member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM7SF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - - - - - -
SP7:
SP8: - -
SP9: -
SP10: - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - -

Relevant External Links for TM7SF3 Gene

GeneLoc Exon Structure for
TM7SF3
ECgene alternative splicing isoforms for
TM7SF3

Expression for TM7SF3 Gene

mRNA expression in normal human tissues for TM7SF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TM7SF3 Gene

This gene is overexpressed in Monocytes (27.3), Islet of Langerhans (18.7), Urine (10.6), and Pancreas (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM7SF3 Gene



SOURCE GeneReport for Unigene cluster for TM7SF3 Gene Hs.438641

mRNA Expression by UniProt/SwissProt for TM7SF3 Gene

Q9NS93-TM7S3_HUMAN
Tissue specificity: Ubiquitous. The highest expression is in kidney.
genes like me logo Genes that share expression patterns with TM7SF3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TM7SF3 Gene

Orthologs for TM7SF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM7SF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TM7SF3 35
  • 86.2 (n)
  • 82.81 (a)
TM7SF3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TM7SF3 35
  • 87.68 (n)
  • 86.62 (a)
TM7SF3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tm7sf3 35
  • 79.17 (n)
  • 78.41 (a)
Tm7sf3 16
Tm7sf3 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TM7SF3 35
  • 99.42 (n)
  • 99.3 (a)
TM7SF3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tm7sf3 35
  • 79.35 (n)
  • 78.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TM7SF3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TM7SF3 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TM7SF3 35
  • 67.15 (n)
  • 62.66 (a)
TM7SF3 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TM7SF3 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18521 35
zebrafish
(Danio rerio)
Actinopterygii tm7sf3 35
  • 56.52 (n)
  • 53.06 (a)
tm7sf3 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012612 35
  • 39.68 (n)
  • 33.33 (a)
Species with no ortholog for TM7SF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM7SF3 Gene

ENSEMBL:
Gene Tree for TM7SF3 (if available)
TreeFam:
Gene Tree for TM7SF3 (if available)

Paralogs for TM7SF3 Gene

No data available for Paralogs for TM7SF3 Gene

Variants for TM7SF3 Gene

Sequence variations from dbSNP and Humsavar for TM7SF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs34735713 - 26,995,391(+) CACAT(A/C/G)GTGGG nc-transcript-variant, reference, missense
rs10771314 - 26,990,575(+) GTCCC(A/G/T)GGAGG intron-variant, nc-transcript-variant, reference, missense
rs4856 -- 26,973,743(-) CTTTT(C/T)CTTAT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs9699 -- 26,971,851(-) TGACC(A/G)TTTAC utr-variant-3-prime
rs15556 -- 26,971,722(-) TATAC(C/T)ATCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TM7SF3 Gene

Variant ID Type Subtype PubMed ID
nsv898935 CNV Loss 21882294
dgv1397n71 CNV Loss 21882294
nsv898938 CNV Loss 21882294
esv2509925 CNV Deletion 19546169
esv2196642 CNV Deletion 18987734
esv2745662 CNV Deletion 23290073
esv2674997 CNV Deletion 23128226
nsv523964 CNV Loss 19592680

Variation tolerance for TM7SF3 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM7SF3 Gene

HapMap Linkage Disequilibrium report
TM7SF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM7SF3 Gene

Disorders for TM7SF3 Gene

Relevant External Links for TM7SF3

Genetic Association Database (GAD)
TM7SF3
Human Genome Epidemiology (HuGE) Navigator
TM7SF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TM7SF3

No disorders were found for TM7SF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM7SF3 Gene

Publications for TM7SF3 Gene

  1. Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3. (PMID: 10828615) Akashi H. … Nakamura Y. (Cytogenet. Cell Genet. 2000) 2 3 4 67
  2. An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. (PMID: 21853325) Beck A. … Zick Y. (Diabetologia 2011) 3
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TM7SF3 Gene

Sources for TM7SF3 Gene

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