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Aliases for TM7SF3 Gene

Aliases for TM7SF3 Gene

  • Transmembrane 7 Superfamily Member 3 2 3
  • Seven Span Transmembrane Protein 4

External Ids for TM7SF3 Gene

Previous GeneCards Identifiers for TM7SF3 Gene

  • GC12M027486
  • GC12M027137
  • GC12M027026
  • GC12M027017
  • GC12M027124
  • GC12M026894

Summaries for TM7SF3 Gene

GeneCards Summary for TM7SF3 Gene

TM7SF3 (Transmembrane 7 Superfamily Member 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM7SF3 Gene

Genomics for TM7SF3 Gene

Regulatory Elements for TM7SF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TM7SF3 Gene

26,971,570 bp from pter
27,014,434 bp from pter
42,865 bases
Minus strand

Genomic View for TM7SF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TM7SF3 Gene

Proteins for TM7SF3 Gene

  • Protein details for TM7SF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 7 superfamily member 3
    Protein Accession:
    Secondary Accessions:
    • B3KMZ3
    • Q9NUS4

    Protein attributes for TM7SF3 Gene

    570 amino acids
    Molecular mass:
    64166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM7SF3 Gene

Proteomics data for TM7SF3 Gene at MOPED

Post-translational modifications for TM7SF3 Gene

  • Ubiquitination at Lys 213, Lys 553, and Lys 558
  • Glycosylation at Asn 27, Asn 61, Asn 75, Asn 87, and Asn 264
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TM7SF3 Gene

Domains & Families for TM7SF3 Gene

Protein Domains for TM7SF3 Gene


Suggested Antigen Peptide Sequences for TM7SF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TM7SF3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TM7SF3 Gene

Function for TM7SF3 Gene

Gene Ontology (GO) - Molecular Function for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TM7SF3: view

Phenotypes for TM7SF3 Gene

GenomeRNAi human phenotypes for TM7SF3:
genes like me logo Genes that share phenotypes with TM7SF3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM7SF3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TM7SF3 Gene

Localization for TM7SF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM7SF3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM7SF3 Gene COMPARTMENTS Subcellular localization image for TM7SF3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1

Gene Ontology (GO) - Cellular Components for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TM7SF3: view

Pathways & Interactions for TM7SF3 Gene

SuperPathways for TM7SF3 Gene

No Data Available

Interacting Proteins for TM7SF3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NS93-TM7S3_HUMAN ENSP00000342322 for TM7SF3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TM7SF3: view

No data available for Pathways by source and SIGNOR curated interactions for TM7SF3 Gene

Drugs & Compounds for TM7SF3 Gene

No Compound Related Data Available

Transcripts for TM7SF3 Gene

Unigene Clusters for TM7SF3 Gene

Transmembrane 7 superfamily member 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM7SF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM7SF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - - - - - -
SP8: - -
SP9: -
SP10: - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - -

Relevant External Links for TM7SF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM7SF3 Gene

mRNA expression in normal human tissues for TM7SF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TM7SF3 Gene

This gene is overexpressed in Monocytes (27.3), Islet of Langerhans (18.7), Urine (10.6), and Pancreas (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM7SF3 Gene

SOURCE GeneReport for Unigene cluster for TM7SF3 Gene Hs.438641

mRNA Expression by UniProt/SwissProt for TM7SF3 Gene

Tissue specificity: Ubiquitous. The highest expression is in kidney
genes like me logo Genes that share expression patterns with TM7SF3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TM7SF3 Gene

Orthologs for TM7SF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM7SF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM7SF3 35
  • 86.2 (n)
  • 82.81 (a)
TM7SF3 36
  • 83 (a)
(Canis familiaris)
Mammalia TM7SF3 35
  • 87.68 (n)
  • 86.62 (a)
TM7SF3 36
  • 87 (a)
(Mus musculus)
Mammalia Tm7sf3 35
  • 79.17 (n)
  • 78.41 (a)
Tm7sf3 16
Tm7sf3 36
  • 78 (a)
(Pan troglodytes)
Mammalia TM7SF3 35
  • 99.42 (n)
  • 99.3 (a)
TM7SF3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tm7sf3 35
  • 79.35 (n)
  • 78.23 (a)
(Monodelphis domestica)
Mammalia TM7SF3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia TM7SF3 36
  • 87 (a)
(Gallus gallus)
Aves TM7SF3 35
  • 67.15 (n)
  • 62.66 (a)
TM7SF3 36
  • 61 (a)
(Anolis carolinensis)
Reptilia TM7SF3 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18521 35
(Danio rerio)
Actinopterygii tm7sf3 35
  • 56.52 (n)
  • 53.06 (a)
tm7sf3 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012612 35
  • 39.68 (n)
  • 33.33 (a)
Species with no ortholog for TM7SF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM7SF3 Gene

Gene Tree for TM7SF3 (if available)
Gene Tree for TM7SF3 (if available)

Paralogs for TM7SF3 Gene

No data available for Paralogs for TM7SF3 Gene

Variants for TM7SF3 Gene

Sequence variations from dbSNP and Humsavar for TM7SF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4856 -- 26,973,743(-) CTTTT(C/T)CTTAT utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs9699 -- 26,971,851(-) TGACC(A/G)TTTAC utr-variant-3-prime
rs15556 -- 26,971,722(-) TATAC(C/T)ATCTG utr-variant-3-prime
rs1053724 -- 26,971,806(-) CTTCA(G/T)TAACA utr-variant-3-prime
rs1127782 -- 26,973,263(-) TGAAG(A/C)TTGAG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TM7SF3 Gene

Variant ID Type Subtype PubMed ID
nsv898935 CNV Loss 21882294
dgv1397n71 CNV Loss 21882294
nsv898938 CNV Loss 21882294
esv2509925 CNV Deletion 19546169
esv2196642 CNV Deletion 18987734
esv2745662 CNV Deletion 23290073
esv2674997 CNV Deletion 23128226
nsv523964 CNV Loss 19592680

Variation tolerance for TM7SF3 Gene

Residual Variation Intolerance Score: 41.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM7SF3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM7SF3 Gene

Disorders for TM7SF3 Gene

Relevant External Links for TM7SF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TM7SF3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM7SF3 Gene

Publications for TM7SF3 Gene

  1. Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3. (PMID: 10828615) Akashi H. … Nakamura Y. (Cytogenet. Cell Genet. 2000) 2 67
  2. An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. (PMID: 21853325) Beck A. … Zick Y. (Diabetologia 2011) 67
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 67
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 67
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67

Products for TM7SF3 Gene

Sources for TM7SF3 Gene

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