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Aliases for TM7SF3 Gene

Aliases for TM7SF3 Gene

  • Transmembrane 7 Superfamily Member 3 2 3 5
  • Seven Span Transmembrane Protein 4

External Ids for TM7SF3 Gene

Previous GeneCards Identifiers for TM7SF3 Gene

  • GC12M027486
  • GC12M027137
  • GC12M027026
  • GC12M027017
  • GC12M027124
  • GC12M026894

Summaries for TM7SF3 Gene

GeneCards Summary for TM7SF3 Gene

TM7SF3 (Transmembrane 7 Superfamily Member 3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM7SF3 Gene

Genomics for TM7SF3 Gene

Regulatory Elements for TM7SF3 Gene

Enhancers for TM7SF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F026877 1.2 FANTOM5 Ensembl ENCODE 15 +135.7 135683 1.7 CTCF ZNF384 BMI1 TBX21 RAD21 RFX3 POLR2A SMARCA4 SMC3 TM7SF3 ENSG00000247903 MED21 ITPR2 GC12M026907
GH12F027330 1.6 FANTOM5 Ensembl ENCODE 10.4 -319.7 -319652 7.4 WRNIP1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF48 ZNF2 GLIS2 ZNF416 STK38L MANSC4 TM7SF3 MED21 HMGB1P49 FGFR1OP2 ARNTL2 ARNTL2-AS1
GH12F027190 1.4 FANTOM5 Ensembl ENCODE 10.7 -178.6 -178550 5.2 INSM2 FEZF1 ZNF366 SCRT2 ZNF391 FOS CREM ZNF362 CEBPB ZEB2 MED21 ENSG00000247903 STK38L TM7SF3 PIR36462 PIR54993
GH12F026869 1.3 Ensembl ENCODE 11 +143.6 143615 2.0 PKNOX1 ATF1 CREB3L1 SIN3A GLI4 FEZF1 ZNF2 YY1 ZNF121 KLF7 TM7SF3 MED21 ITPR2 GC12M026907
GH12F026935 1.1 ENCODE 11.8 +75.1 75140 8.3 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ENSG00000247903 TM7SF3 MANSC4 MED21 ITPR2 FGFR1OP2 PIR61598
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TM7SF3 on UCSC Golden Path with GeneCards custom track

Promoters for TM7SF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000428103 434 2001 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207
ENSR00001775938 1734 201 KLF1 ZNF362 ZBTB33 MLLT1 ZBTB40

Genomic Location for TM7SF3 Gene

26,971,570 bp from pter
27,014,434 bp from pter
42,865 bases
Minus strand

Genomic View for TM7SF3 Gene

Genes around TM7SF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM7SF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM7SF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM7SF3 Gene

Proteins for TM7SF3 Gene

  • Protein details for TM7SF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 7 superfamily member 3
    Protein Accession:
    Secondary Accessions:
    • B3KMZ3
    • Q9NUS4

    Protein attributes for TM7SF3 Gene

    570 amino acids
    Molecular mass:
    64166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM7SF3 Gene

Post-translational modifications for TM7SF3 Gene

  • Ubiquitination at Lys 213, Lys 553, and Lys 558
  • Glycosylation at Asn 27, Asn 61, Asn 75, Asn 87, and Asn 264
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TM7SF3 Gene

Domains & Families for TM7SF3 Gene

Protein Domains for TM7SF3 Gene


Suggested Antigen Peptide Sequences for TM7SF3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TM7SF3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TM7SF3 Gene

Function for TM7SF3 Gene

Gene Ontology (GO) - Molecular Function for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TM7SF3: view
genes like me logo Genes that share phenotypes with TM7SF3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TM7SF3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM7SF3 Gene

Localization for TM7SF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM7SF3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM7SF3 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TM7SF3: view

Pathways & Interactions for TM7SF3 Gene

SuperPathways for TM7SF3 Gene

No Data Available

Interacting Proteins for TM7SF3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9NS93-TM7S3_HUMAN ENSP00000342322 for TM7SF3 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TM7SF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TM7SF3: view

No data available for Pathways by source and SIGNOR curated interactions for TM7SF3 Gene

Transcripts for TM7SF3 Gene

Unigene Clusters for TM7SF3 Gene

Transmembrane 7 superfamily member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM7SF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - -
SP6: - - - - - - - -
SP8: - -
SP9: -
SP10: - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - -

Relevant External Links for TM7SF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM7SF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TM7SF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TM7SF3 Gene

This gene is overexpressed in Monocytes (27.3), Islet of Langerhans (18.7), Urine (10.6), and Pancreas (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TM7SF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TM7SF3 Gene:


SOURCE GeneReport for Unigene cluster for TM7SF3 Gene:


mRNA Expression by UniProt/SwissProt for TM7SF3 Gene:

Tissue specificity: Ubiquitous. The highest expression is in kidney.
genes like me logo Genes that share expression patterns with TM7SF3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TM7SF3 Gene

Orthologs for TM7SF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM7SF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM7SF3 34 35
  • 99.42 (n)
(Canis familiaris)
Mammalia TM7SF3 34 35
  • 87.68 (n)
(Ornithorhynchus anatinus)
Mammalia TM7SF3 35
  • 87 (a)
(Bos Taurus)
Mammalia TM7SF3 34 35
  • 86.2 (n)
(Rattus norvegicus)
Mammalia Tm7sf3 34
  • 79.35 (n)
(Mus musculus)
Mammalia Tm7sf3 34 16 35
  • 79.17 (n)
(Monodelphis domestica)
Mammalia TM7SF3 35
  • 72 (a)
(Gallus gallus)
Aves TM7SF3 34 35
  • 67.15 (n)
(Anolis carolinensis)
Reptilia TM7SF3 35
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18521 34
(Danio rerio)
Actinopterygii tm7sf3 34 35
  • 56.52 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012612 34
  • 39.68 (n)
Species where no ortholog for TM7SF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM7SF3 Gene

Gene Tree for TM7SF3 (if available)
Gene Tree for TM7SF3 (if available)

Paralogs for TM7SF3 Gene

No data available for Paralogs for TM7SF3 Gene

Variants for TM7SF3 Gene

Sequence variations from dbSNP and Humsavar for TM7SF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10082734 -- 26,989,465(+) CACAG(A/G)TTTTC intron-variant
rs10082871 -- 26,989,253(+) caaca(C/T)ggtga intron-variant
rs10219474 -- 26,974,565(+) AGGCA(G/T)TGATC intron-variant
rs10400476 -- 26,998,958(+) TAGAA(C/T)AACTA intron-variant
rs10431217 -- 26,994,084(+) AAGTT(A/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM7SF3 Gene

Variant ID Type Subtype PubMed ID
esv2196642 CNV deletion 18987734
esv2509925 CNV deletion 19546169
esv2674997 CNV deletion 23128226
esv2745662 CNV deletion 23290073
esv3628924 CNV loss 21293372
esv3892164 CNV loss 25118596
esv3892165 CNV loss 25118596
nsv523964 CNV loss 19592680

Variation tolerance for TM7SF3 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM7SF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM7SF3 Gene

Disorders for TM7SF3 Gene

Relevant External Links for TM7SF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM7SF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM7SF3 Gene

Publications for TM7SF3 Gene

  1. Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3. (PMID: 10828615) Akashi H. … Nakamura Y. (Cytogenet. Cell Genet. 2000) 2 3 4 64
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. (PMID: 21853325) Beck A. … Zick Y. (Diabetologia 2011) 3 64

Products for TM7SF3 Gene

Sources for TM7SF3 Gene

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