TM7SF3 Gene
protein-coding GIFtS: 44
GCID: GC12M027124
|
|
transmembrane 7 superfamily member 3
| |
Aliases
for TM7SF3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane 7 Superfamily Member 31 2 | | Seven Span Transmembrane Protein2 3 | | Seven Transmembrane Protein TM7SF32 |
Export aliases for TM7SF3 gene to outside databasesPrevious GC identifers: GC12M027486 GC12M027137 GC12M027026 GC12M027017 GC12M026894 |
Summaries
for TM7SF3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TM7SF3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TM7SF3 gene promoter:
E2F-3a AhR AML1a E2F-2 Nkx2-5 Arnt POU2F1 POU2F1a SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TM7SF3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM7SF3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q11-q12 Ensembl cytogenetic band: 12p11.23 HGNC cytogenetic band: 12q11-q12TM7SF3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M027124: view genomic region
(about GC identifiers)
Start:
|
27,124,503 bp from pter |
End:
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27,167,367 bp from pter |
Size:
|
42,865 bases |
Orientation:
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minus strand |
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Proteins
for TM7SF3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM7S3_HUMAN, Q9NS93 (See
protein sequence)Recommended Name: Transmembrane 7 superfamily member 3 precursor Size: 570 amino acids; 64166 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B3KMZ3 Q9NUS4Explore the universe of human proteins at neXtProt for TM7SF3: NX_Q9NS93
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS93
TM7SF3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057635.1
ENSEMBL proteins: ENSP00000342322 ENSP00000445756 ENSP00000440146 ENSP00000444362 ENSP00000439318 ENSP00000440736 ENSP00000441924 ENSP00000445156 ENSP00000442617 ENSP00000440323 ENSP00000441027 ENSP00000444632 ENSP00000438848 ENSP00000440262 ENSP00000439987
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TM7SF3 for ontologies About GeneDecksing
TM7SF3 Antibody Products:
Assay Products for TM7SF3: |
Protein
Domains /
Families
for TM7SF3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TM7SF3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NS93ProtoNet protein and cluster: Q9NS93 |
Function
for TM7SF3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM7SF3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM7SF3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TM7SF3 (NM_016551) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM7SF3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM7SF3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM7SF3 |
|
Pathways & Interactions
for TM7SF3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TM7SF3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for TM7SF3 (Q9NS933 ENSP000003423224) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TM7SF3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TM7SF3
Search CenterWatch for drugs/clinical trials and news about TM7SF3 / TM7S3
|
Transcripts
for TM7SF3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TM7SF3 gene: NM_016551.2 Unigene Cluster for TM7SF3: Transmembrane 7 superfamily member 3 Hs.438641 [show with all ESTs]Unigene Representative Sequence: NM_01655118/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000343028(uc010sjl.2) ENST00000544179 ENST00000545344 ENST00000545303
ENST00000537406 ENST00000535260 ENST00000543882 ENST00000541081 ENST00000542667
ENST00000543655 ENST00000535819 ENST00000543803 ENST00000542019 ENST00000539741
ENST00000543088 ENST00000535423 ENST00000512808 ENST00000545600
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM7SF3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM7SF3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TM7SF3 (NM_016551) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM7SF3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM7SF3 |
Additional cDNA sequence: AB032470.1 AK002031.1 AK023085.1 AK091115.1 BC005176.2 24 DOTS entries: DT.453726 DT.212050 DT.95160685 DT.91772319 DT.95160683 DT.121178570 DT.100811297 DT.40253830 DT.100789123 DT.121178552 DT.100655306 DT.97862531 DT.102823351 DT.91772312 DT.91772313 DT.95160677 DT.100029300 DT.121178539 DT.121178541 DT.121178562 DT.95160673 DT.95160681 DT.95205029 DT.99930966 24/339 AceView cDNA sequences (see all 339): BM798724 BF366419 BM766267 AW072665 AI270490 CA502943 AU120021 AA683509 AI769338 BM772097 AI382663 AK023085 BM983218 BI019748 BM755058 AA455731 AA903712 BQ944736 AA328743 BG403521 CA430577 BU622213 BM749564 AW157153
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TM7SF3 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TM7SF3
|
Expression
for TM7SF3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TM7SF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGAGTGG
About this image
See TM7SF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TM7SF3
SOURCE GeneReport for Unigene cluster: Hs.438641
UniProtKB/Swiss-Prot: TM7S3_HUMAN, Q9NS93Tissue specificity: Ubiquitous. The highest expression is in kidney
SABiosciences Custom PCR Arrays for TM7SF3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM7SF3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TM7SF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM7SF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM7SF3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM7SF3 |
Orthologs
for TM7SF3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TM7SF3 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for TM7SF3 (if available)
TreeFam Gene Tree for TM7SF3 (if available) |
Paralogs
for TM7SF3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TM7SF3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TM7SF3 (27124503 - 27167367 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TM7SF3
1 CNV: 101463
1 Indel: 45028 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM7SF3 |
|
Disorders
/ Diseases
for TM7SF3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TM7SF3 for disorders About MalaCards
TM7SF3 for disorders About GeneDecksing
OMIM gene information: 605181
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: TM7SF3 (1 document)
Export disorders for TM7SF3 gene to outside databases
|
Publications
for TM7SF3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TM7SF3 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TM7SF3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3. (PubMed id 10828615)1, 2, 3 Akashi H.... Nakamura Y. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cy tokine-induced death of pancreatic beta cells. (PubMed id 21853325)1 Beck A....Zick Y. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1 He C....Hunter D.J. (2010)
|
External Searches for TM7SF3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TM7SF3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TM7SF3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TM7SF3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TM7SF3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TM7SF3 gene:
Search GeneIP for patents involving TM7SF3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TM7SF3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TM7SF3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TM7SF3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM7SF3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TM7SF3 | | OriGene 3'-UTR Clone for TM7SF3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM7SF3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM7SF3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TM7SF3 | | OriGene Custom Protein Services for TM7SF3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TM7SF3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM7SF3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM7SF3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TM7SF3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM7SF3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM7SF3 |
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 | | | TM7SF3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM7SF3 |
|  |  |  | | | | Search ThermoFisher Antibodies for TM7SF3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM7SF3 |
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