TM6SF2 Gene
protein-coding GIFtS: 39
GCID: GC19M019375
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transmembrane 6 superfamily member 2
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Aliases
for TM6SF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane 6 Superfamily Member 21 2 | | Lpr41 | | KIAA19265 |
Export aliases for TM6SF2 gene to outside databasesPrevious GC identifers: GC19M019859 GC19M019756 GC19M019210 GC19M019226 GC19M019228 GC19M019236 GC19M018938 |
Summaries
for TM6SF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TM6SF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TM6SF2 gene promoter:
NF-1/L NF-1 AML1a GATA-3 Lmo2 E47 GATA-1 GATA-2 FOXC1 COMP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TM6SF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM6SF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3-p12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.3-p12TM6SF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M019375: view genomic region
(about GC identifiers)
Start:
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19,375,173 bp from pter |
End:
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19,384,200 bp from pter |
Size:
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9,028 bases |
Orientation:
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minus strand |
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Proteins
for TM6SF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM6S2_HUMAN, Q9BZW4 (See
protein sequence)Recommended Name: Transmembrane 6 superfamily member 2 Size: 377 amino acids; 42554 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q0IJ64Alternative splicing: 2 isoforms: Q9BZW4-1 Q9BZW4-2 Explore the universe of human proteins at neXtProt for TM6SF2: NX_Q9BZW4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BZW4
TM6SF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001524.2
ENSEMBL proteins: ENSP00000374014
Human Recombinant Protein Products for TM6SF2:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
NAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TM6SF2 for ontologies About GeneDecksing
TM6SF2 Antibody Products:
Assay Products for TM6SF2: |
Protein
Domains /
Families
for TM6SF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TM6SF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BZW4ProtoNet protein and cluster: Q9BZW4 UniProtKB/Swiss-Prot: TM6S2_HUMAN, Q9BZW4Similarity: Belongs to the TM6SF family |
Function
for TM6SF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TM6SF2 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TM6SF2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM6SF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM6SF2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TM6SF2 (NM_001001524) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM6SF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM6SF2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM6SF2 |
|
Pathways & Interactions
for TM6SF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TM6SF2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TM6SF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TM6SF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TM6SF2
Search CenterWatch for drugs/clinical trials and news about TM6SF2 / TM6S2
|
Transcripts
for TM6SF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TM6SF2 gene (2 alternative transcripts): NM_203510.1 NM_001001524.2 Unigene Cluster for TM6SF2: Transmembrane 6 superfamily member 2 Hs.531624 [show with all ESTs]Unigene Representative Sequence: NM_0010015246 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000590431 ENST00000591001 ENST00000431465 ENST00000389363(uc002nmd.1)
ENST00000589564 ENST00000586107
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM6SF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM6SF2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TM6SF2 (NM_001001524) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM6SF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM6SF2 |
Additional cDNA sequence: AF255923.1 BC120986.1 BC120987.1 4 DOTS entries: DT.121492893 DT.433037 DT.91827291 DT.97822872 24/43 AceView cDNA sequences (see all 43): NM_001001524 AK097070 AK026307 AW450803 NM_203510 BE047138 AB067513 AB107883 BX096239 AY262756 CK300169 AF255923 BM683825 AA907902 NM_023002 BI757362 N99350 AA984368 AL389940 BQ189795 BQ083418 AL389941 BQ184042 Z42718
GeneLoc Exon Structure
|
Expression
for TM6SF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TM6SF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCCTTTCA
About this image
See TM6SF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TM6SF2
SOURCE GeneReport for Unigene cluster: Hs.531624
SABiosciences Custom PCR Arrays for TM6SF2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM6SF2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TM6SF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM6SF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM6SF2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM6SF2 |
Orthologs
for TM6SF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TM6SF2 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for TM6SF2 (if available)
TreeFam Gene Tree for TM6SF2 (if available) |
Paralogs
for TM6SF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TM6SF2 gene
- TM6SF12 ENSG000002676292
2 SIMAP similar genes for TM6SF2 using alignment to 1 protein entry: TM6S2_HUMAN:HAPLN4 TM6SF1
TM6SF2 for paralogs About GeneDecksing
|
Genomic Variants
for TM6SF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TM6SF2 (19375173 - 19384200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TM6SF2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM6SF2 |
|
Disorders
/ Diseases
for TM6SF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TM6SF2 for disorders About MalaCards
TM6SF2 for disorders About GeneDecksing
OMIM gene information: 606563
OMIM disorders: --
Export disorders for TM6SF2 gene to outside databases
|
Publications
for TM6SF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TM6SF2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TM6SF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-q26 and 19p13.3- p12. (PubMed id 11124529)1, 2, 3 Carim-Todd L.... Sumoy L. (2000)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1 Nagase T....Ohara O. (2001)
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External Searches for TM6SF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TM6SF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TM6SF2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TM6SF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TM6SF2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TM6SF2 gene:
Search GeneIP for patents involving TM6SF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TM6SF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TM6SF2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TM6SF2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM6SF2 | | | OriGene Protein Over-expression Lysate for TM6SF2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TM6SF2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM6SF2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM6SF2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TM6SF2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM6SF2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM6SF2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TM6SF2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM6SF2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM6SF2 |
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| | | | Search Tocris compounds for TM6SF2 |
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 | | | TM6SF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM6SF2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TM6SF2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM6SF2 |
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