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Aliases for TM6SF1 Gene

Aliases for TM6SF1 Gene

  • Transmembrane 6 Superfamily Member 1 2 3 5

External Ids for TM6SF1 Gene

Previous GeneCards Identifiers for TM6SF1 Gene

  • GC15P079702
  • GC15P076809
  • GC15P081354
  • GC15P081496
  • GC15P081567
  • GC15P083776
  • GC15P060039
  • GC15P083108
  • GC15P083109

Summaries for TM6SF1 Gene

GeneCards Summary for TM6SF1 Gene

TM6SF1 (Transmembrane 6 Superfamily Member 1) is a Protein Coding gene. An important paralog of this gene is TM6SF2.

UniProtKB/Swiss-Prot for TM6SF1 Gene

  • May function as sterol isomerase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM6SF1 Gene

Genomics for TM6SF1 Gene

Regulatory Elements for TM6SF1 Gene

Enhancers for TM6SF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TM6SF1 on UCSC Golden Path with GeneCards custom track

Promoters for TM6SF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TM6SF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM6SF1 Gene

Chromosome:
15
Start:
83,107,407 bp from pter
End:
83,144,854 bp from pter
Size:
37,448 bases
Orientation:
Plus strand

Genomic View for TM6SF1 Gene

Genes around TM6SF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM6SF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM6SF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM6SF1 Gene

Proteins for TM6SF1 Gene

  • Protein details for TM6SF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZW5-TM6S1_HUMAN
    Recommended name:
    Transmembrane 6 superfamily member 1
    Protein Accession:
    Q9BZW5
    Secondary Accessions:
    • A8K7T5
    • H3BU56
    • Q4U0U5

    Protein attributes for TM6SF1 Gene

    Size:
    370 amino acids
    Molecular mass:
    41636 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM6SF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TM6SF1 Gene

Proteomics data for TM6SF1 Gene at MOPED

Post-translational modifications for TM6SF1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TM6SF1 Gene

Domains & Families for TM6SF1 Gene

Protein Domains for TM6SF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TM6SF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZW5

UniProtKB/Swiss-Prot:

TM6S1_HUMAN :
  • Contains 2 EXPERA domains.
  • Belongs to the TM6SF family.
Domain:
  • Contains 2 EXPERA domains.
Family:
  • Belongs to the TM6SF family.
genes like me logo Genes that share domains with TM6SF1: view

No data available for Gene Families for TM6SF1 Gene

Function for TM6SF1 Gene

Molecular function for TM6SF1 Gene

UniProtKB/Swiss-Prot Function:
May function as sterol isomerase.

Gene Ontology (GO) - Molecular Function for TM6SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TM6SF1: view
genes like me logo Genes that share phenotypes with TM6SF1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM6SF1 Gene

Localization for TM6SF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM6SF1 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TM6SF1 Gene COMPARTMENTS Subcellular localization image for TM6SF1 gene
Compartment Confidence
lysosome 4
vacuole 4
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for TM6SF1 Gene

Pathways & Interactions for TM6SF1 Gene

SuperPathways for TM6SF1 Gene

No Data Available

Interacting Proteins for TM6SF1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000317000%0d%0a9606.ENSP00000407401%0d%0a
Selected Interacting proteins: ENSP00000317000 for TM6SF1 Gene via STRING

Symbol External ID(s) Details
PEX5

Gene Ontology (GO) - Biological Process for TM6SF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TM6SF1 Gene

Drugs & Compounds for TM6SF1 Gene

No Compound Related Data Available

Transcripts for TM6SF1 Gene

Unigene Clusters for TM6SF1 Gene

Transmembrane 6 superfamily member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM6SF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - - - - -
SP4:

Relevant External Links for TM6SF1 Gene

GeneLoc Exon Structure for
TM6SF1
ECgene alternative splicing isoforms for
TM6SF1

Expression for TM6SF1 Gene

mRNA expression in normal human tissues for TM6SF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM6SF1 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for TM6SF1 Gene

This gene is overexpressed in Monocytes (31.0), Peripheral blood mononuclear cells (26.6), and Platelet (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM6SF1 Gene



SOURCE GeneReport for Unigene cluster for TM6SF1 Gene Hs.513094

mRNA Expression by UniProt/SwissProt for TM6SF1 Gene

Q9BZW5-TM6S1_HUMAN
Tissue specificity: Enhanced expression in spleen, testis and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TM6SF1: view

Protein tissue co-expression partners for TM6SF1 Gene

Primer Products

Orthologs for TM6SF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM6SF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TM6SF1 35
  • 91.98 (n)
  • 95.14 (a)
TM6SF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TM6SF1 35
  • 94.14 (n)
  • 96.49 (a)
TM6SF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tm6sf1 35
  • 89.64 (n)
  • 94.32 (a)
Tm6sf1 16
Tm6sf1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TM6SF1 35
  • 99.37 (n)
  • 99.73 (a)
TM6SF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tm6sf1 35
  • 88.6 (n)
  • 93.27 (a)
oppossum
(Monodelphis domestica)
Mammalia TM6SF1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves TM6SF1 35
  • 77.3 (n)
  • 80.54 (a)
TM6SF1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TM6SF1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tm6sf1 35
  • 68.84 (n)
  • 68.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2482 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
CSA.5317 36
  • 29 (a)
ManyToMany
Species with no ortholog for TM6SF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TM6SF1 Gene

ENSEMBL:
Gene Tree for TM6SF1 (if available)
TreeFam:
Gene Tree for TM6SF1 (if available)

Paralogs for TM6SF1 Gene

Paralogs for TM6SF1 Gene

(1) SIMAP similar genes for TM6SF1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TM6SF1: view

Variants for TM6SF1 Gene

Sequence variations from dbSNP and Humsavar for TM6SF1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_012844 -
VAR_024661 -

Variation tolerance for TM6SF1 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TM6SF1 Gene

Disorders for TM6SF1 Gene

Relevant External Links for TM6SF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TM6SF1

No disorders were found for TM6SF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM6SF1 Gene

Publications for TM6SF1 Gene

  1. Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-q26 and 19p13.3- p12. (PMID: 11124529) Carim-Todd L. … Sumoy L. (Cytogenet. Cell Genet. 2000) 2 3 4 67
  2. Validation of DNA promoter hypermethylation biomarkers in breast cancer--a short report. (PMID: 25123395) de Groot J.S. … Moelans C.B. (Cell Oncol (Dordr) 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for TM6SF1 Gene

Sources for TM6SF1 Gene

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