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Aliases for TM6SF1 Gene

Aliases for TM6SF1 Gene

  • Transmembrane 6 Superfamily Member 1 2 3

External Ids for TM6SF1 Gene

Previous GeneCards Identifiers for TM6SF1 Gene

  • GC15P079702
  • GC15P076809
  • GC15P081354
  • GC15P081496
  • GC15P081567
  • GC15P083776
  • GC15P060039

Summaries for TM6SF1 Gene

GeneCards Summary for TM6SF1 Gene

TM6SF1 (Transmembrane 6 Superfamily Member 1) is a Protein Coding gene. An important paralog of this gene is TM6SF2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM6SF1 Gene

Genomics for TM6SF1 Gene

Regulatory Elements for TM6SF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TM6SF1 Gene

Start:
83,107,407 bp from pter
End:
83,144,854 bp from pter
Size:
37,448 bases
Orientation:
Plus strand

Genomic View for TM6SF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TM6SF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM6SF1 Gene

Proteins for TM6SF1 Gene

  • Protein details for TM6SF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZW5-TM6S1_HUMAN
    Recommended name:
    Transmembrane 6 superfamily member 1
    Protein Accession:
    Q9BZW5
    Secondary Accessions:
    • A8K7T5
    • H3BU56
    • Q4U0U5

    Protein attributes for TM6SF1 Gene

    Size:
    370 amino acids
    Molecular mass:
    41636 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM6SF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TM6SF1 Gene

Proteomics data for TM6SF1 Gene at MOPED

Post-translational modifications for TM6SF1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TM6SF1 Gene

Domains for TM6SF1 Gene

Protein Domains for TM6SF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TM6SF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZW5

UniProtKB/Swiss-Prot:

TM6S1_HUMAN :
  • Q9BZW5
Family:
  • Belongs to the TM6SF family.
genes like me logo Genes that share domains with TM6SF1: view

No data available for Gene Families for TM6SF1 Gene

Function for TM6SF1 Gene

Gene Ontology (GO) - Molecular Function for TM6SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TM6SF1: view

Phenotypes for TM6SF1 Gene

GenomeRNAi human phenotypes for TM6SF1:
genes like me logo Genes that share phenotypes with TM6SF1: view

Animal Model Products

CRISPR Products

miRNA for TM6SF1 Gene

miRTarBase miRNAs that target TM6SF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM6SF1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TM6SF1 Gene

Localization for TM6SF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM6SF1 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TM6SF1 Gene COMPARTMENTS Subcellular localization image for TM6SF1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TM6SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM6SF1: view

Pathways for TM6SF1 Gene

SuperPathways for TM6SF1 Gene

No Data Available

Interacting Proteins for TM6SF1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000317000%0d%0a9606.ENSP00000407401%0d%0a
Selected Interacting proteins: ENSP00000317000 for TM6SF1 Gene via STRING

Symbol External ID(s) Details
PEX5

Gene Ontology (GO) - Biological Process for TM6SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TM6SF1: view

No data available for Pathways by source for TM6SF1 Gene

Transcripts for TM6SF1 Gene

Unigene Clusters for TM6SF1 Gene

Transmembrane 6 superfamily member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM6SF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM6SF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: - - - - - -
SP4:

Relevant External Links for TM6SF1 Gene

GeneLoc Exon Structure for
TM6SF1
ECgene alternative splicing isoforms for
TM6SF1

Expression for TM6SF1 Gene

mRNA expression in normal human tissues for TM6SF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM6SF1 Gene

This gene is overexpressed in Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TM6SF1 Gene

SOURCE GeneReport for Unigene cluster for TM6SF1 Gene Hs.513094

mRNA Expression by UniProt/SwissProt for TM6SF1 Gene

Q9BZW5-TM6S1_HUMAN
Tissue specificity: Enhanced expression in spleen, testis and peripheral blood leukocytes
genes like me logo Genes that share expressions with TM6SF1: view

In Situ Assay Products

Orthologs for TM6SF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM6SF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM6SF1 35
  • 99.37 (n)
  • 99.73 (a)
TM6SF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TM6SF1 35
  • 91.98 (n)
  • 95.14 (a)
TM6SF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TM6SF1 35
  • 94.14 (n)
  • 96.49 (a)
TM6SF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tm6sf1 35
  • 89.64 (n)
  • 94.32 (a)
Tm6sf1 16
Tm6sf1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TM6SF1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tm6sf1 35
  • 88.6 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves TM6SF1 35
  • 77.3 (n)
  • 80.54 (a)
TM6SF1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TM6SF1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2482 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tm6sf1 35
  • 68.84 (n)
  • 68.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
CSA.5317 36
  • 29 (a)
ManyToMany
Species with no ortholog for TM6SF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TM6SF1 Gene

ENSEMBL:
Gene Tree for TM6SF1 (if available)
TreeFam:
Gene Tree for TM6SF1 (if available)

Paralogs for TM6SF1 Gene

Paralogs for TM6SF1 Gene

Selected SIMAP similar genes for TM6SF1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TM6SF1: view

Variants for TM6SF1 Gene

Sequence variations from dbSNP and Humsavar for TM6SF1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1989 - 83,112,879(+) AACCA(C/T)CCCGG reference, missense, utr-variant-5-prime, nc-transcript-variant
rs896563 -- 83,112,529(+) CCAGA(C/T)GTGTC intron-variant
rs1062232 - 83,107,730(+) GGCCA(C/T)CCCGG missense, reference, utr-variant-5-prime, nc-transcript-variant
rs1075619 -- 83,112,722(+) ATGCA(C/T)TCAAT intron-variant
rs1901544 -- 83,106,500(-) TATTT(A/T)TTTTT upstream-variant-2KB

Relevant External Links for TM6SF1 Gene

HapMap Linkage Disequilibrium report
TM6SF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TM6SF1 Gene

Disorders for TM6SF1 Gene

No disorders were found for TM6SF1 Gene.

No data available for UniProtKB/Swiss-Prot for TM6SF1 Gene

Publications for TM6SF1 Gene

  1. Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-q26 and 19p13.3- p12. (PMID: 11124529) Carim-Todd L. … Sumoy L. (Cytogenet. Cell Genet. 2000) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for TM6SF1 Gene

Sources for TM6SF1 Gene

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