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Aliases for TM4SF5 Gene

Aliases for TM4SF5 Gene

  • Transmembrane 4 L Six Family Member 5 2 3 5
  • Transmembrane 4 Superfamily Member 5 2
  • Tetraspan Transmembrane Protein L6H 4

External Ids for TM4SF5 Gene

Previous GeneCards Identifiers for TM4SF5 Gene

  • GC17P005102
  • GC17P005020
  • GC17P004625
  • GC17P004881
  • GC17P004621
  • GC17P004675
  • GC17P004563

Summaries for TM4SF5 Gene

Entrez Gene Summary for TM4SF5 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM4SF5 Gene

TM4SF5 (Transmembrane 4 L Six Family Member 5) is a Protein Coding gene. An important paralog of this gene is TM4SF1.

Gene Wiki entry for TM4SF5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF5 Gene

Genomics for TM4SF5 Gene

Regulatory Elements for TM4SF5 Gene

Enhancers for TM4SF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F004174 1.4 FANTOM5 Ensembl ENCODE 4.5 -594.6 -594560 5.5 HLF ZZEF1 CYB5D2 ATP2A3 TM4SF5 UBE2G1 P2RX1 NCBP3 PIR35722 PIR52300
GH17F004769 1.4 FANTOM5 Ensembl ENCODE 0.8 -0.8 -764 3.4 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS PAF1 SP5 NFYC MXD4 CXCL16 ZMYND15 VMO1 ENSG00000262165 ARRB2 SPAG7 MINK1 SCIMP TM4SF5
GH17F004768 0.8 Ensembl 0.8 -3.6 -3584 0.2 ZNF707 TM4SF5 ZMYND15
GH17F004770 0.8 FANTOM5 0.8 -3.3 -3330 0.3 ZNF366 CXCL16 ZMYND15 ARRB2 SCIMP SPAG7 MINK1 TM4SF5
GH17F004764 1.6 FANTOM5 Ensembl ENCODE 0.4 -6.0 -5984 3.4 CTCF ZNF792 PATZ1 ZBTB33 PRDM1 ATF2 SPI1 SP7 ZMYND15 CXCL16 ARRB2 C17orf107 VMO1 ENSG00000262165 SCIMP MINK1 SPAG7 TM4SF5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TM4SF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM4SF5 Gene

Chromosome:
17
Start:
4,771,884 bp from pter
End:
4,783,213 bp from pter
Size:
11,330 bases
Orientation:
Plus strand

Genomic View for TM4SF5 Gene

Genes around TM4SF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF5 Gene

Proteins for TM4SF5 Gene

  • Protein details for TM4SF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14894-T4S5_HUMAN
    Recommended name:
    Transmembrane 4 L6 family member 5
    Protein Accession:
    O14894
    Secondary Accessions:
    • Q17RW9
    • Q6IB79

    Protein attributes for TM4SF5 Gene

    Size:
    197 amino acids
    Molecular mass:
    20823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF5 Gene

Post-translational modifications for TM4SF5 Gene

  • Glycosylation at Asn 138 and Asn 155

Other Protein References for TM4SF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TM4SF5 Gene

Domains & Families for TM4SF5 Gene

Protein Domains for TM4SF5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TM4SF5 Gene

Graphical View of Domain Structure for InterPro Entry

O14894

UniProtKB/Swiss-Prot:

T4S5_HUMAN :
  • Belongs to the L6 tetraspanin family.
Family:
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF5: view

No data available for Gene Families for TM4SF5 Gene

Function for TM4SF5 Gene

Molecular function for TM4SF5 Gene

GENATLAS Biochemistry:
transmembrane 4 superfamily,member 5 (tetraspanin family),overexpressed in pancreas cancer,highly homolog to the tumor associated antigen L6
genes like me logo Genes that share phenotypes with TM4SF5: view

Animal Model Products

miRNA for TM4SF5 Gene

miRTarBase miRNAs that target TM4SF5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF5 Gene

Localization for TM4SF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TM4SF5 Gene COMPARTMENTS Subcellular localization image for TM4SF5 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TM4SF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9479038
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM4SF5: view

Pathways & Interactions for TM4SF5 Gene

SuperPathways for TM4SF5 Gene

No Data Available

Interacting Proteins for TM4SF5 Gene

Selected Interacting proteins: O14894-T4S5_HUMAN for TM4SF5 Gene via IID

Gene Ontology (GO) - Biological Process for TM4SF5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TM4SF5 Gene

Transcripts for TM4SF5 Gene

mRNA/cDNA for TM4SF5 Gene

Unigene Clusters for TM4SF5 Gene

Transmembrane 4 L six family member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF5 Gene

No ASD Table

Relevant External Links for TM4SF5 Gene

GeneLoc Exon Structure for
TM4SF5
ECgene alternative splicing isoforms for
TM4SF5

Expression for TM4SF5 Gene

mRNA expression in normal human tissues for TM4SF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF5 Gene

This gene is overexpressed in Liver (x41.8) and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for TM4SF5 Gene

This gene is overexpressed in Gallbladder (43.5) and Platelet (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TM4SF5 Gene



Protein tissue co-expression partners for TM4SF5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TM4SF5 Gene:

TM4SF5

SOURCE GeneReport for Unigene cluster for TM4SF5 Gene:

Hs.184194

mRNA Expression by UniProt/SwissProt for TM4SF5 Gene:

O14894-T4S5_HUMAN
Tissue specificity: Intestine. Overexpressed in pancreatic cancers.
genes like me logo Genes that share expression patterns with TM4SF5: view

Primer Products

Orthologs for TM4SF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM4SF5 34 35
  • 98.48 (n)
mouse
(Mus musculus)
Mammalia Tm4sf5 34 16 35
  • 84.01 (n)
cow
(Bos Taurus)
Mammalia TM4SF5 34 35
  • 83.33 (n)
dog
(Canis familiaris)
Mammalia TM4SF5 34 35
  • 82.06 (n)
rat
(Rattus norvegicus)
Mammalia Tm4sf5 34
  • 81.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TM4SF5 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TM4SF5 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 39 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TM4SF5 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490620 34
  • 66.84 (n)
zebrafish
(Danio rerio)
Actinopterygii tm4sf5 34 35
  • 58.38 (n)
Species where no ortholog for TM4SF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF5 Gene

ENSEMBL:
Gene Tree for TM4SF5 (if available)
TreeFam:
Gene Tree for TM4SF5 (if available)

Paralogs for TM4SF5 Gene

Paralogs for TM4SF5 Gene

(4) SIMAP similar genes for TM4SF5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TM4SF5: view

Variants for TM4SF5 Gene

Sequence variations from dbSNP and Humsavar for TM4SF5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1060231 -- 4,771,977(+) TCTGC(C/T)TCGTC reference, missense
rs111274373 -- 4,782,741(+) GGGCA(C/T)TCGCT intron-variant
rs111433893 -- 4,772,589(+) CTGTG(C/T)GGACT intron-variant
rs111452217 -- 4,773,951(+) TGGCT(C/T)ACGCC intron-variant
rs111647296 -- 4,782,216(+) CTCAG(C/T)CTCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF5 Gene

Variant ID Type Subtype PubMed ID
nsv574273 CNV gain 21841781
nsv833346 CNV loss 17160897

Variation tolerance for TM4SF5 Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TM4SF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF5 Gene

Disorders for TM4SF5 Gene

Relevant External Links for TM4SF5

Genetic Association Database (GAD)
TM4SF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TM4SF5

No disorders were found for TM4SF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF5 Gene

Publications for TM4SF5 Gene

  1. Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. (PMID: 9479038) Mueller-Pillasch F. … Gress T.M. (Gene 1998) 2 3 4 22 64
  2. Transmembrane 4 L Six Family Member 5 (TM4SF5)-Mediated Epithelial-Mesenchymal Transition in Liver Diseases. (PMID: 26404468) Lee J.W. (Int Rev Cell Mol Biol 2015) 2 3 64
  3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 46 64
  4. Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. (PMID: 18357344) Lee S.A. … Lee J.W. (J. Clin. Invest. 2008) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TM4SF5 Gene

Sources for TM4SF5 Gene

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