Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TM4SF5 Gene

protein-coding GIFtS: 47
GCID: GC17P004675

transmembrane 4 L six family member 5

(Previous name: transmembrane 4 superfamily member 5 )

Explore 3 diseases affiliated with
TM4SF5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane 4 L Six Family Member 5¹ ²
Transmembrane 4 Superfamily Member 5¹ ²
Tetraspan Transmembrane Protein L6H² ³
Transmembrane 4 L6 Family Member 5²

External Ids:	HGNC: 11857¹	Entrez Gene: 9032²	Ensembl: ENSG00000142484⁷	OMIM: 604657⁵	UniProtKB: O14894³

Export aliases for TM4SF5 gene to outside databases

Previous GC identifers: GC17P005102 GC17P005020 GC17P004625 GC17P004881 GC17P004621 GC17P004563

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TM4SF5:

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family.

Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains.

The proteins mediate signal transduction events that play a role in the regulation of cell development, activation,

growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and

structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of

this protein may be associated with the uncontrolled growth of tumour cells. (provided by RefSeq, Jul 2008)

Gene Wiki entry for TM4SF5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TM4SF5 gene promoter:
PPAR-alpha NF-1 NF-kappaB2 RelA LCR-F1 NF-kappaB NF-kappaB1 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TM4SF5 promoter sequence

Search SABiosciences Chromatin IP Primers for TM4SF5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM4SF5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3

TM4SF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TM4SF5 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P004675: view genomic region (about GC identifiers)

Start:	4,675,179 bp from pter	End:	4,686,506 bp from pter
Size:	11,328 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T4S5_HUMAN, O14894 (See protein sequence)

Recommended Name: Transmembrane 4 L6 family member 5

Size: 197 amino acids; 20823 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q17RW9 Q6IB79

Explore the universe of human proteins at neXtProt for TM4SF5: NX_O14894

TM4SF5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003954.2

ENSEMBL proteins:

ENSP00000270560

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TM4SF5
	GenScript Custom Purified and Recombinant Proteins Services for TM4SF5
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TM4SF5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9479038

TM4SF5 for ontologies About GeneDecksing

TM4SF5 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TM4SF5
	GenScript Custom Superior Antibodies Services for TM4SF5
	Novus Biologicals TM4SF5 Antibody
	Search for Antibodies for TM4SF5 at Abcam
	Uscn Antibodies for TM4SF5
	Search ThermoFisher Antibodies for TM4SF5

Assay Products for TM4SF5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TM4SF5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TM4SF5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TM4SF5 for domains About GeneDecksing

1 InterPro domain/family:

IPR008661 L6_membrane

Graphical View of Domain Structure for InterPro Entry O14894

ProtoNet protein and cluster: O14894

1 Blocks protein family: IPB008661 L6 membrane

UniProtKB/Swiss-Prot: T4S5_HUMAN, O14894

Similarity: Belongs to the L6 tetraspanin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for TM4SF5:

transmembrane 4 superfamily,member 5 (tetraspanin family),overexpressed in pancreas cancer,highly homolog to the tumor

associated antigen L6

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TM4SF5
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TM4SF5
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TM4SF5 (see all 7) OriGene shRNA RFP: TM4SF5 OriGene siRNA: TM4SF5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TM4SF5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TM4SF5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM4SF5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM4SF5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TM4SF5 (NM_003963)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TM4SF5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM4SF5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TM4SF5
		Search LifeMap BioReagents cell lines for TM4SF5

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TM4SF5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TM4SF5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TM4SF5
Search CenterWatch for drugs/clinical trials and news about TM4SF5 / T4S5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TM4SF5 gene:

NM_003963.2

Unigene Cluster for TM4SF5:

Transmembrane 4 L six family member 5

Hs.184194 [show with all ESTs]

Unigene Representative Sequence: W84524

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000576530 ENST00000270560(uc002fyw.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TM4SF5
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TM4SF5
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TM4SF5 (see all 7) OriGene shRNA RFP: TM4SF5 OriGene siRNA: TM4SF5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TM4SF5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM4SF5 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM4SF5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TM4SF5 (NM_003963)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TM4SF5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM4SF5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM4SF5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TM4SF5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM4SF5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM4SF5

Additional cDNA sequence:

AF027204.1 BC069519.1 BC093688.1 BC117163.1 CR456925.1 CR541798.1

2 DOTS entries:

DT.102821322 DT.86852291

24/47 AceView cDNA sequences (see all 47):

NM_003963 CD617743 AF027204 W84524 BC069519 CD617746 CR541798 CR456925

CD617742 AA844492 AX772822 T25072 CD617745 W84512 BF435758 CD617741

BG186169 AI242043 BV179260 AA910944 H49257 AI284409 AA631650 BV168028

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TM4SF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGGCTTCA

About this image

TM4SF5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TM4SF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TM4SF5

SOURCE GeneReport for Unigene cluster: Hs.184194

UniProtKB/Swiss-Prot: T4S5_HUMAN, O14894

Tissue specificity: Intestine. Overexpressed in pancreatic cancers

SABiosciences Custom PCR Arrays for TM4SF5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM4SF5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TM4SF5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM4SF5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM4SF5

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TM4SF5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF5 gene from 2/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	TM4SF5⁶	--	54(a)	1 ↔ 1	AAWZ02039070(5010-7845)
zebrafish (Danio rerio)	Actinopterygii	tm4sf5¹	transmembrane 4 L six family member 5	58.99(n) 57.59(a)		436645 NM_001002372.1 NP_001002372.1

ENSEMBL Gene Tree for TM4SF5 (if available)
TreeFam Gene Tree for TM4SF5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TM4SF5 gene

TM4SF4² TM4SF19² TM4SF18² TM4SF1²

4 SIMAP similar genes for TM4SF5 using alignment to 2 protein entries: T4S5_HUMAN (see all proteins):

TM4SF1 TM4SF4 TM4SF18 TM4SF19

TM4SF5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs117769089^1,2		--	4673321(+)	`CCACTG/AGCTGG`	1	--	us2k¹		1		NA	120
rs7220035^1,2	C,F,A,H,	--	4673433(+)	`TAGGGC/TTCATT`	1	--	us2k¹		10		NA WA CSA EA	373
rs143093743^1,2		--	4673464(+)	`CTGTTG/TGCTTC`	1	--	us2k¹		0	--	--	--	--
rs183638863^1,2		--	4673529(+)	`GCCTGA/GGTGAC`	1	--	us2k¹		0	--	--	--	--
rs112438463^1,2	C,	--	4673552(+)	`ATCTCA/-AAAAA`	1	--	us2k¹		1		CSA	2
rs147490081^1,2		--	4673566(+)	`AACAAC/GAAAAA`	1	--	us2k¹		0	--	--	--	--
rs9890797^1,2	C,F,	--	4673609(+)	`AGTCCC/TAGCTA`	1	--	us2k¹		5		NA	10
rs112158401^1,2		--	4673622(+)	`CGGGAA/GGCTGA`	1	--	us2k¹		1		CSA	1
rs182072306^1,2		--	4673694(+)	`CCAGCC/TTGGGC`	1	--	us2k¹		0	--	--	--	--
rs117384765^1,2	F,	--	4673713(+)	`GAGACC/ACTGGT`	1	--	us2k¹		1		NA	120

HapMap Linkage Disequilibrium report for TM4SF5 (4675179 - 4686506 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TM4SF5
1 CNV: 4985

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM4SF5

DNA2.0 Custom Variant and Variant Library Synthesis for TM4SF5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TM4SF5 for disorders           About GeneDecksing

OMIM gene information: 604657    OMIM disorders: --

3 diseases for TM4SF5:    About MalaCards

gastric cancer pancreatic cancer pancreatitis

Export disorders for TM4SF5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TM4SF5 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with TM4SF5)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. (PubMed id 9479038)^{1, 2, 3, 9} Mueller-Pillasch F.... Gress T.M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. (PubMed id 18357344)^{1, 9} Lee S.A....Lee J.W. (2008)
Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)¹ Inouye M....de Bakker P.I. (2012)
Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)¹ Demirkan A....Schmitz G. (2012)
Cross-talk between TGFb1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition. (PubMed id 22292774)¹ Kang M....Lee J.W. (2012)
JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation. (PubMed id 22014979)¹ Kim H....Lee J.W. (2012)
Gefitinib resistance of cancer cells correlated with T M4SF5-mediated epithelial-mesenchymal transition. (PubMed id 22178131)¹ Lee M.S....Lee J.W. (2012)
Proteasome inhibition causes epithelial-mesenchymal t ransition upon TM4SF5 expression. (PubMed id 21328452)¹ Kim J.Y....Cho M. (2011)
Modulation of signaling between TM4SF5 and integrins in tumor microenvironment. (PubMed id 21196261)¹ Lee S.A....Lee J.W. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9032	HGNC: 11857	AceView: TM4SF5	Ensembl:ENSG00000142484	euGenes: HUgn9032
ECgene: TM4SF5	H-InvDB: TM4SF5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TM4SF5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TM4SF5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TM4SF5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TM4SF5 gene:
Search GeneIP for patents involving TM4SF5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for TM4SF5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TM4SF5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM4SF5
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TM4SF5		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM4SF5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM4SF5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TM4SF5		OriGene Custom Protein Services for TM4SF5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TM4SF5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM4SF5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM4SF5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TM4SF5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM4SF5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM4SF5

	GenScript Custom Purified and Recombinant Proteins Services for TM4SF5		GenScript cDNA clones with any tag delivered in your preferred vector for TM4SF5
	GenScript Custom Assay Services for TM4SF5		GenScript Custom Superior Antibodies Services for TM4SF5
	GenScript Custom overexpressing Cell Line Services for TM4SF5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TM4SF5 promoter
	Search Chromatin IP Primers for TM4SF5
	RT² qPCR Primer Assay in human, mouse, rat TM4SF5
	GNC Network for TM4SF5
	SABiosciences Custom PCR Arrays for TM4SF5

Search Tocris compounds for TM4SF5

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TM4SF5 antibodies

	Search for Antibodies for TM4SF5 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TM4SF5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TM4SF5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TM4SF5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TM4SF5

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TM4SF5
	SwitchGear Promoter luciferase reporter plasmids for TM4SF5

Search ThermoFisher Antibodies for TM4SF5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM4SF5

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TM4SF5 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TM4SF5 Gene

transmembrane 4 L six family member 5

Aliases
for TM4SF5 gene

Summaries
for TM4SF5 gene

Genomic Views
for TM4SF5 gene

Proteins
for TM4SF5 gene

Protein Domains /
Families
for TM4SF5 gene

Function
for TM4SF5 gene

Pathways & Interactions
for TM4SF5 gene

Drugs & Compounds
for TM4SF5 gene

Transcripts
for TM4SF5 gene

Expression
for TM4SF5 gene

Orthologs
for TM4SF5 gene

Paralogs
for TM4SF5 gene

Genomic Variants
for TM4SF5 gene

Disorders / Diseases
for TM4SF5 gene

Publications
for TM4SF5 gene

External Searches for TM4SF5 gene

Genome Databases showing TM4SF5 gene

Other Databases showing TM4SF5 gene

Specialized Databases showing TM4SF5 gene

Intellectual Property
for TM4SF5 gene

Products
for TM4SF5 gene

View Random Gene

Advanced Search

Export list of displayed genes

TM4SF5 Gene

transmembrane 4 L six family member 5

Aliasesfor TM4SF5 gene

Summariesfor TM4SF5 gene

Genomic Viewsfor TM4SF5 gene

Proteinsfor TM4SF5 gene

Protein Domains /Familiesfor TM4SF5 gene

Functionfor TM4SF5 gene

Pathways & Interactionsfor TM4SF5 gene

Drugs & Compoundsfor TM4SF5 gene

Transcriptsfor TM4SF5 gene

Expression for TM4SF5 gene

Orthologsfor TM4SF5 gene

Paralogsfor TM4SF5 gene

Genomic Variantsfor TM4SF5 gene

Disorders / Diseasesfor TM4SF5 gene

Publicationsfor TM4SF5 gene

External Searches for TM4SF5 gene

Genome Databases showing TM4SF5 gene

Other Databases showing TM4SF5 gene

Specialized Databases showing TM4SF5 gene

Intellectual Propertyfor TM4SF5 gene

Productsfor TM4SF5 gene

View Random Gene

Aliases
for TM4SF5 gene

Summaries
for TM4SF5 gene

Genomic Views
for TM4SF5 gene

Proteins
for TM4SF5 gene

Protein Domains /
Families
for TM4SF5 gene

Function
for TM4SF5 gene

Pathways & Interactions
for TM4SF5 gene

Drugs & Compounds
for TM4SF5 gene

Transcripts
for TM4SF5 gene

Expression
for TM4SF5 gene

Orthologs
for TM4SF5 gene

Paralogs
for TM4SF5 gene

Genomic Variants
for TM4SF5 gene

Disorders / Diseases
for TM4SF5 gene

Publications
for TM4SF5 gene

Intellectual Property
for TM4SF5 gene

Products
for TM4SF5 gene