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Aliases for TM4SF5 Gene

Aliases for TM4SF5 Gene

  • Transmembrane 4 L Six Family Member 5 2 3
  • Transmembrane 4 Superfamily Member 5 2
  • Tetraspan Transmembrane Protein L6H 4

External Ids for TM4SF5 Gene

Previous GeneCards Identifiers for TM4SF5 Gene

  • GC17P005102
  • GC17P005020
  • GC17P004625
  • GC17P004881
  • GC17P004621
  • GC17P004675
  • GC17P004563

Summaries for TM4SF5 Gene

Entrez Gene Summary for TM4SF5 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM4SF5 Gene

TM4SF5 (Transmembrane 4 L Six Family Member 5) is a Protein Coding gene. An important paralog of this gene is TM4SF19.

Gene Wiki entry for TM4SF5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF5 Gene

Genomics for TM4SF5 Gene

Regulatory Elements for TM4SF5 Gene

Genomic Location for TM4SF5 Gene

4,771,884 bp from pter
4,783,213 bp from pter
11,330 bases
Plus strand

Genomic View for TM4SF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TM4SF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF5 Gene

Proteins for TM4SF5 Gene

  • Protein details for TM4SF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 5
    Protein Accession:
    Secondary Accessions:
    • Q17RW9
    • Q6IB79

    Protein attributes for TM4SF5 Gene

    197 amino acids
    Molecular mass:
    20823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF5 Gene

Proteomics data for TM4SF5 Gene at MOPED

Post-translational modifications for TM4SF5 Gene

  • Glycosylation at Asn 138 and Asn 155

Other Protein References for TM4SF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TM4SF5 Gene

Domains & Families for TM4SF5 Gene

Protein Domains for TM4SF5 Gene


Suggested Antigen Peptide Sequences for TM4SF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF5: view

No data available for Gene Families for TM4SF5 Gene

Function for TM4SF5 Gene

Molecular function for TM4SF5 Gene

GENATLAS Biochemistry:
transmembrane 4 superfamily,member 5 (tetraspanin family),overexpressed in pancreas cancer,highly homolog to the tumor associated antigen L6

Phenotypes for TM4SF5 Gene

genes like me logo Genes that share phenotypes with TM4SF5: view

Animal Model Products

miRNA for TM4SF5 Gene

miRTarBase miRNAs that target TM4SF5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM4SF5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF5 Gene

Localization for TM4SF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM4SF5 Gene COMPARTMENTS Subcellular localization image for TM4SF5 gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TM4SF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9479038
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with TM4SF5: view

Pathways & Interactions for TM4SF5 Gene

SuperPathways for TM4SF5 Gene

No Data Available

Interacting Proteins for TM4SF5 Gene

Gene Ontology (GO) - Biological Process for TM4SF5 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF5 Gene

Drugs & Compounds for TM4SF5 Gene

No Compound Related Data Available

Transcripts for TM4SF5 Gene

mRNA/cDNA for TM4SF5 Gene

Unigene Clusters for TM4SF5 Gene

Transmembrane 4 L six family member 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM4SF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF5 Gene

No ASD Table

Relevant External Links for TM4SF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF5 Gene

mRNA expression in normal human tissues for TM4SF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF5 Gene

This gene is overexpressed in Liver (x41.8) and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for TM4SF5 Gene

This gene is overexpressed in Gallbladder (43.5) and Platelet (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TM4SF5 Gene

SOURCE GeneReport for Unigene cluster for TM4SF5 Gene Hs.184194

mRNA Expression by UniProt/SwissProt for TM4SF5 Gene

Tissue specificity: Intestine. Overexpressed in pancreatic cancers
genes like me logo Genes that share expression patterns with TM4SF5: view

Protein tissue co-expression partners for TM4SF5 Gene

Primer Products

In Situ Assay Products

Orthologs for TM4SF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM4SF5 35
  • 83.33 (n)
  • 82.14 (a)
TM4SF5 36
  • 82 (a)
(Canis familiaris)
Mammalia TM4SF5 35
  • 82.06 (n)
  • 82.74 (a)
TM4SF5 36
  • 83 (a)
(Mus musculus)
Mammalia Tm4sf5 35
  • 84.01 (n)
  • 82.65 (a)
Tm4sf5 16
Tm4sf5 36
  • 82 (a)
(Pan troglodytes)
Mammalia TM4SF5 35
  • 98.48 (n)
  • 98.48 (a)
TM4SF5 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tm4sf5 35
  • 81.63 (n)
  • 81.63 (a)
(Monodelphis domestica)
Mammalia TM4SF5 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia TM4SF5 36
  • 60 (a)
(Gallus gallus)
Aves -- 36
  • 39 (a)
(Anolis carolinensis)
Reptilia TM4SF5 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490620 35
  • 66.84 (n)
  • 62.56 (a)
(Danio rerio)
Actinopterygii tm4sf5 35
  • 58.38 (n)
  • 56.99 (a)
tm4sf5 36
  • 54 (a)
Species with no ortholog for TM4SF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF5 Gene

Gene Tree for TM4SF5 (if available)
Gene Tree for TM4SF5 (if available)

Paralogs for TM4SF5 Gene

Paralogs for TM4SF5 Gene

(4) SIMAP similar genes for TM4SF5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TM4SF5: view

Variants for TM4SF5 Gene

Sequence variations from dbSNP and Humsavar for TM4SF5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3851 -- 4,783,119(-) TGAGG(G/T)GTGTC reference, synonymous-codon
rs13520 -- 4,780,800(+) TGTCC(A/C/G)GGGAT synonymous-codon, reference
rs735003 -- 4,778,415(-) CTGAT(A/C)TCGAA intron-variant
rs735004 -- 4,778,396(-) CTCAA(C/G)CAATC intron-variant
rs746988 -- 4,773,419(-) TCCCT(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF5 Gene

Variant ID Type Subtype PubMed ID
nsv833346 CNV Loss 17160897
nsv907618 CNV Loss 21882294

Variation tolerance for TM4SF5 Gene

Residual Variation Intolerance Score: 68.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF5 Gene

Disorders for TM4SF5 Gene

Relevant External Links for TM4SF5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TM4SF5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF5 Gene

Publications for TM4SF5 Gene

  1. Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. (PMID: 9479038) Mueller-Pillasch F. … Gress T.M. (Gene 1998) 2 23 67
  2. Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. (PMID: 18357344) Lee S.A. … Lee J.W. (J. Clin. Invest. 2008) 23 67
  3. Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells. (PMID: 25627085) Lee D. … Lee J.W. (Hepatology 2015) 67
  4. Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells. (PMID: 24912675) Ryu J. … Lee J.W. (Mol. Cell. Biol. 2014) 67
  5. Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model. (PMID: 25268742) Kim Y.E. … Lee Y. (Oncotarget 2014) 67

Products for TM4SF5 Gene

Sources for TM4SF5 Gene

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