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Aliases for TM4SF4 Gene

Aliases for TM4SF4 Gene

  • Transmembrane 4 L Six Family Member 4 2 3 5
  • Intestine And Liver Tetraspan Membrane Protein 3 4
  • Transmembrane 4 Superfamily Member 4 2 3
  • Il-TMP 3 4
  • ILTMP 3 4
  • Intestinal And Liver (Il) Tetraspan Membrane Protein 3

External Ids for TM4SF4 Gene

Previous GeneCards Identifiers for TM4SF4 Gene

  • GC03P146120
  • GC03P150076
  • GC03P150473
  • GC03P150512
  • GC03P150674
  • GC03P149191
  • GC03P146564

Summaries for TM4SF4 Gene

Entrez Gene Summary for TM4SF4 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

GeneCards Summary for TM4SF4 Gene

TM4SF4 (Transmembrane 4 L Six Family Member 4) is a Protein Coding gene. An important paralog of this gene is TM4SF19.

UniProtKB/Swiss-Prot for TM4SF4 Gene

  • Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF4 Gene

Genomics for TM4SF4 Gene

Regulatory Elements for TM4SF4 Gene

Enhancers for TM4SF4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TM4SF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM4SF4 Gene

149,473,974 bp from pter
149,503,394 bp from pter
29,421 bases
Plus strand

Genomic View for TM4SF4 Gene

Genes around TM4SF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF4 Gene

Proteins for TM4SF4 Gene

  • Protein details for TM4SF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 4
    Protein Accession:
    Secondary Accessions:
    • B2RDA4

    Protein attributes for TM4SF4 Gene

    202 amino acids
    Molecular mass:
    21396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF4 Gene

Proteomics data for TM4SF4 Gene at MOPED

Post-translational modifications for TM4SF4 Gene

  • N-glycosylated. Glycosylation is required for the growth inhibitory effect.
  • Glycosylation at Asn 124 and Asn 156

Other Protein References for TM4SF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TM4SF4

No data available for DME Specific Peptides for TM4SF4 Gene

Domains & Families for TM4SF4 Gene

Protein Domains for TM4SF4 Gene


Suggested Antigen Peptide Sequences for TM4SF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF4: view

No data available for Gene Families for TM4SF4 Gene

Function for TM4SF4 Gene

Molecular function for TM4SF4 Gene

UniProtKB/Swiss-Prot Function:
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
genes like me logo Genes that share phenotypes with TM4SF4: view

Animal Models for TM4SF4 Gene

MGI Knock Outs for TM4SF4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TM4SF4 Gene

Localization for TM4SF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM4SF4 Gene COMPARTMENTS Subcellular localization image for TM4SF4 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TM4SF4 Gene

Pathways & Interactions for TM4SF4 Gene

SuperPathways for TM4SF4 Gene

No Data Available

Interacting Proteins for TM4SF4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000305852 P48230-T4S4_HUMAN for TM4SF4 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for TM4SF4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF4 Gene

Drugs & Compounds for TM4SF4 Gene

No Compound Related Data Available

Transcripts for TM4SF4 Gene

mRNA/cDNA for TM4SF4 Gene

Unigene Clusters for TM4SF4 Gene

Transmembrane 4 L six family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF4 Gene

No ASD Table

Relevant External Links for TM4SF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF4 Gene

mRNA expression in normal human tissues for TM4SF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF4 Gene

This gene is overexpressed in Liver (x37.3), Pancreas (x8.3), and Small Intestine - Terminal Ileum (x4.8).

Protein differential expression in normal tissues from HIPED for TM4SF4 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TM4SF4 Gene

SOURCE GeneReport for Unigene cluster for TM4SF4 Gene Hs.133527

mRNA Expression by UniProt/SwissProt for TM4SF4 Gene

Tissue specificity: Jejunum and liver.
genes like me logo Genes that share expression patterns with TM4SF4: view

Protein tissue co-expression partners for TM4SF4 Gene

- Elite partner

Primer Products

Orthologs for TM4SF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM4SF4 35
  • 85.66 (n)
  • 82.26 (a)
TM4SF4 36
  • 70 (a)
(Canis familiaris)
Mammalia TM4SF4 35
  • 89.44 (n)
  • 89.6 (a)
TM4SF4 36
  • 90 (a)
(Mus musculus)
Mammalia Tm4sf4 35
  • 86.8 (n)
  • 87.62 (a)
Tm4sf4 16
Tm4sf4 36
  • 88 (a)
(Pan troglodytes)
Mammalia TM4SF4 35
  • 99.24 (n)
  • 98.86 (a)
TM4SF4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tm4sf4 35
  • 86.8 (n)
  • 87.62 (a)
(Monodelphis domestica)
Mammalia TM4SF4 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia TM4SF4 36
  • 73 (a)
(Gallus gallus)
Aves TM4SF4 35
  • 68.65 (n)
  • 70.81 (a)
TM4SF4 36
  • 73 (a)
(Anolis carolinensis)
Reptilia TM4SF4 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75723 35
tm4sf4 35
  • 67.49 (n)
  • 71.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia tm4sf4-prov 35
(Danio rerio)
Actinopterygii Dr.3563 35
tm4sf4 35
  • 63.08 (n)
  • 61.29 (a)
tm4sf4 36
  • 62 (a)
Species with no ortholog for TM4SF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF4 Gene

Gene Tree for TM4SF4 (if available)
Gene Tree for TM4SF4 (if available)

Paralogs for TM4SF4 Gene

Paralogs for TM4SF4 Gene

(4) SIMAP similar genes for TM4SF4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TM4SF4: view

Variants for TM4SF4 Gene

Sequence variations from dbSNP and Humsavar for TM4SF4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9793 -- 149,474,777(+) ATTGG(A/G)GACAA utr-variant-5-prime
rs4314111 -- 149,480,889(+) CTTGC(A/C)CTGTT intron-variant
rs4320033 -- 149,481,468(+) GGGCT(A/C)CTGCA intron-variant
rs4321472 -- 149,477,951(+) TCACA(A/C)CTGGT intron-variant
rs4321473 -- 149,478,208(+) TGGCG(C/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF4 Gene

Variant ID Type Subtype PubMed ID
esv29983 CNV Gain 17803354
nsv4056 CNV Loss 18451855

Variation tolerance for TM4SF4 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TM4SF4 Gene

Disorders for TM4SF4 Gene

Relevant External Links for TM4SF4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM4SF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF4 Gene

Publications for TM4SF4 Gene

  1. A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. (PMID: 7665614) Wice B.M. … Gordon J.I. (J. Biol. Chem. 1995) 2 3 4 67
  2. Association of TM4SF4 with the human thiamine transporter-2 in intestinal epithelial cells. (PMID: 24282057) Subramanian V.S. … Said H.M. (Dig. Dis. Sci. 2014) 3
  3. TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. (PMID: 25344917) Choi S.I. … Kim I.G. (Oncotarget 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo. (PMID: 23296076) Wang L. … Zhao M. (Acta Biochim. Biophys. Sin. (Shanghai) 2013) 3

Products for TM4SF4 Gene

Sources for TM4SF4 Gene