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Aliases for TM4SF4 Gene

Aliases for TM4SF4 Gene

  • Transmembrane 4 L Six Family Member 4 2 3 5
  • Intestine And Liver Tetraspan Membrane Protein 3 4
  • Transmembrane 4 Superfamily Member 4 2 3
  • Il-TMP 3 4
  • ILTMP 3 4
  • Intestinal And Liver (Il) Tetraspan Membrane Protein 3
  • Transmembrane 4 L6 Family Member 4 3

External Ids for TM4SF4 Gene

Previous GeneCards Identifiers for TM4SF4 Gene

  • GC03P146120
  • GC03P150076
  • GC03P150473
  • GC03P150512
  • GC03P150674
  • GC03P149191
  • GC03P146564

Summaries for TM4SF4 Gene

Entrez Gene Summary for TM4SF4 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

GeneCards Summary for TM4SF4 Gene

TM4SF4 (Transmembrane 4 L Six Family Member 4) is a Protein Coding gene. An important paralog of this gene is TM4SF1.

UniProtKB/Swiss-Prot for TM4SF4 Gene

  • Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF4 Gene

Genomics for TM4SF4 Gene

Regulatory Elements for TM4SF4 Gene

Enhancers for TM4SF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F149471 1.3 FANTOM5 Ensembl ENCODE 24.8 +0.1 93 5.5 TBP PKNOX1 BRCA1 RAD21 RFX5 YY1 SMARCC2 RCOR1 FOS SMARCC1 TM4SF4 COMMD2 CP LOC100421817
GH03F149479 1.4 Ensembl ENCODE 13.8 +6.2 6206 2.0 PKNOX1 ARID4B SIN3A ZNF48 ZNF143 DEK MIER2 REST KAT8 SREBF1 TM4SF4 WWTR1 LOC100421817
GH03F149481 0.2 Ensembl 13.8 +7.5 7527 0.2 ZNF766 TM4SF4 LOC100421817
GH03F149447 0.8 Ensembl ENCODE 12.5 -24.8 -24774 3.2 JUN TEAD4 MAX RFX5 ZNF316 GATA3 NFE2 FOS MAFK TCF7L2 TM4SF4 TM4SF1 TM4SF1-AS1 TM4SF18 GC03M149445 FKBP1AP4
GH03F149393 1.4 Ensembl ENCODE 12.4 -79.0 -78974 3.6 ELF3 ARID4B ZNF48 ZNF2 RAD21 RFX5 ZNF143 DEK MIXL1 ZNF654 TM4SF4 TM4SF1 ENSG00000243885 LOC105374151
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TM4SF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM4SF4 Gene

Chromosome:
3
Start:
149,473,974 bp from pter
End:
149,503,394 bp from pter
Size:
29,421 bases
Orientation:
Plus strand

Genomic View for TM4SF4 Gene

Genes around TM4SF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF4 Gene

Proteins for TM4SF4 Gene

  • Protein details for TM4SF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48230-T4S4_HUMAN
    Recommended name:
    Transmembrane 4 L6 family member 4
    Protein Accession:
    P48230
    Secondary Accessions:
    • B2RDA4

    Protein attributes for TM4SF4 Gene

    Size:
    202 amino acids
    Molecular mass:
    21396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF4 Gene

Post-translational modifications for TM4SF4 Gene

  • N-glycosylated. Glycosylation is required for the growth inhibitory effect.
  • Glycosylation at Asn 124 and Asn 156

Other Protein References for TM4SF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TM4SF4

No data available for DME Specific Peptides for TM4SF4 Gene

Domains & Families for TM4SF4 Gene

Protein Domains for TM4SF4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TM4SF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48230

UniProtKB/Swiss-Prot:

T4S4_HUMAN :
  • Belongs to the L6 tetraspanin family.
Family:
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF4: view

No data available for Gene Families for TM4SF4 Gene

Function for TM4SF4 Gene

Molecular function for TM4SF4 Gene

UniProtKB/Swiss-Prot Function:
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

Gene Ontology (GO) - Molecular Function for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TM4SF4: view
genes like me logo Genes that share phenotypes with TM4SF4: view

Animal Models for TM4SF4 Gene

MGI Knock Outs for TM4SF4:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TM4SF4 Gene

Localization for TM4SF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TM4SF4 Gene COMPARTMENTS Subcellular localization image for TM4SF4 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with TM4SF4: view

Pathways & Interactions for TM4SF4 Gene

SuperPathways for TM4SF4 Gene

No Data Available

Interacting Proteins for TM4SF4 Gene

Gene Ontology (GO) - Biological Process for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042246 tissue regeneration IEA --
genes like me logo Genes that share ontologies with TM4SF4: view

No data available for Pathways by source and SIGNOR curated interactions for TM4SF4 Gene

Transcripts for TM4SF4 Gene

mRNA/cDNA for TM4SF4 Gene

Unigene Clusters for TM4SF4 Gene

Transmembrane 4 L six family member 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF4 Gene

No ASD Table

Relevant External Links for TM4SF4 Gene

GeneLoc Exon Structure for
TM4SF4
ECgene alternative splicing isoforms for
TM4SF4

Expression for TM4SF4 Gene

mRNA expression in normal human tissues for TM4SF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF4 Gene

This gene is overexpressed in Liver (x37.3), Pancreas (x8.3), and Small Intestine - Terminal Ileum (x4.8).

Protein differential expression in normal tissues from HIPED for TM4SF4 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TM4SF4 Gene



Protein tissue co-expression partners for TM4SF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TM4SF4 Gene:

TM4SF4

SOURCE GeneReport for Unigene cluster for TM4SF4 Gene:

Hs.133527

mRNA Expression by UniProt/SwissProt for TM4SF4 Gene:

P48230-T4S4_HUMAN
Tissue specificity: Jejunum and liver.
genes like me logo Genes that share expression patterns with TM4SF4: view

Primer Products

Orthologs for TM4SF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM4SF4 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia TM4SF4 34 35
  • 89.44 (n)
mouse
(Mus musculus)
Mammalia Tm4sf4 34 16 35
  • 86.8 (n)
rat
(Rattus norvegicus)
Mammalia Tm4sf4 34
  • 86.8 (n)
cow
(Bos Taurus)
Mammalia TM4SF4 34 35
  • 85.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TM4SF4 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TM4SF4 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves TM4SF4 34 35
  • 68.65 (n)
lizard
(Anolis carolinensis)
Reptilia TM4SF4 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tm4sf4 34
  • 67.49 (n)
MGC75723 34
African clawed frog
(Xenopus laevis)
Amphibia tm4sf4-prov 34
zebrafish
(Danio rerio)
Actinopterygii tm4sf4 34 35
  • 63.08 (n)
Dr.3563 34
Species where no ortholog for TM4SF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF4 Gene

ENSEMBL:
Gene Tree for TM4SF4 (if available)
TreeFam:
Gene Tree for TM4SF4 (if available)

Paralogs for TM4SF4 Gene

Paralogs for TM4SF4 Gene

(4) SIMAP similar genes for TM4SF4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TM4SF4: view

Variants for TM4SF4 Gene

Sequence variations from dbSNP and Humsavar for TM4SF4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10460856 -- 149,476,010(+) TCCAG(A/C)CAGGA intron-variant
rs10935760 -- 149,475,636(+) GGTTA(C/G)TCAGC intron-variant
rs10935762 -- 149,498,511(+) ATGTG(C/T)GAAGT intron-variant
rs10935763 -- 149,501,283(+) ACTCA(A/C)AGAGG intron-variant
rs111297430 -- 149,476,470(+) CCATC(A/G)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF4 Gene

Variant ID Type Subtype PubMed ID
esv29983 CNV gain 17803354
nsv1131736 CNV deletion 24896259
nsv4056 CNV deletion 18451855
nsv979887 CNV duplication 23825009

Variation tolerance for TM4SF4 Gene

Residual Variation Intolerance Score: 78.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TM4SF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF4 Gene

Disorders for TM4SF4 Gene

Relevant External Links for TM4SF4

Genetic Association Database (GAD)
TM4SF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TM4SF4

No disorders were found for TM4SF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF4 Gene

Publications for TM4SF4 Gene

  1. A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. (PMID: 7665614) Wice B.M. … Gordon J.I. (J. Biol. Chem. 1995) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Association of TM4SF4 with the human thiamine transporter-2 in intestinal epithelial cells. (PMID: 24282057) Subramanian V.S. … Said H.M. (Dig. Dis. Sci. 2014) 3 64

Products for TM4SF4 Gene

Sources for TM4SF4 Gene

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