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Aliases for TM4SF4 Gene

Aliases for TM4SF4 Gene

  • Transmembrane 4 L Six Family Member 4 2 3
  • Intestine And Liver Tetraspan Membrane Protein 3 4
  • Transmembrane 4 Superfamily Member 4 2 3
  • Il-TMP 3 4
  • ILTMP 3 4
  • Intestinal And Liver (Il) Tetraspan Membrane Protein 3

External Ids for TM4SF4 Gene

Previous GeneCards Identifiers for TM4SF4 Gene

  • GC03P146120
  • GC03P150076
  • GC03P150473
  • GC03P150512
  • GC03P150674
  • GC03P149191
  • GC03P146564

Summaries for TM4SF4 Gene

Entrez Gene Summary for TM4SF4 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

GeneCards Summary for TM4SF4 Gene

TM4SF4 (Transmembrane 4 L Six Family Member 4) is a Protein Coding gene. An important paralog of this gene is TM4SF19.

UniProtKB/Swiss-Prot for TM4SF4 Gene

  • Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF4 Gene

Genomics for TM4SF4 Gene

Regulatory Elements for TM4SF4 Gene

Genomic Location for TM4SF4 Gene

Chromosome:
3
Start:
149,473,974 bp from pter
End:
149,503,394 bp from pter
Size:
29,421 bases
Orientation:
Plus strand

Genomic View for TM4SF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TM4SF4 Gene

Proteins for TM4SF4 Gene

  • Protein details for TM4SF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48230-T4S4_HUMAN
    Recommended name:
    Transmembrane 4 L6 family member 4
    Protein Accession:
    P48230
    Secondary Accessions:
    • B2RDA4

    Protein attributes for TM4SF4 Gene

    Size:
    202 amino acids
    Molecular mass:
    21396 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF4 Gene

Proteomics data for TM4SF4 Gene at MOPED

Post-translational modifications for TM4SF4 Gene

  • N-glycosylated. Glycosylation is required for the growth inhibitory effect.
  • Glycosylation at Asn 124 and Asn 156

Other Protein References for TM4SF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TM4SF4 Gene

Domains & Families for TM4SF4 Gene

Protein Domains for TM4SF4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TM4SF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48230

UniProtKB/Swiss-Prot:

T4S4_HUMAN :
  • Belongs to the L6 tetraspanin family.
Family:
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF4: view

No data available for Gene Families for TM4SF4 Gene

Function for TM4SF4 Gene

Molecular function for TM4SF4 Gene

UniProtKB/Swiss-Prot Function:
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation

Gene Ontology (GO) - Molecular Function for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TM4SF4: view
genes like me logo Genes that share phenotypes with TM4SF4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM4SF4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TM4SF4 Gene

Localization for TM4SF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF4 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TM4SF4: view

No data available for Subcellular locations from COMPARTMENTS for TM4SF4 Gene

Pathways & Interactions for TM4SF4 Gene

SuperPathways for TM4SF4 Gene

No Data Available

Interacting Proteins for TM4SF4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305852%0d%0a9606.ENSP00000359375%0d%0a9606.ENSP00000212015%0d%0a
Selected Interacting proteins: P48230-T4S4_HUMAN ENSP00000305852 for TM4SF4 Gene via UniProtKB STRING I2D

Gene Ontology (GO) - Biological Process for TM4SF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042246 tissue regeneration IEA --
genes like me logo Genes that share ontologies with TM4SF4: view

No data available for Pathways by source and SIGNOR curated interactions for TM4SF4 Gene

Drugs & Compounds for TM4SF4 Gene

No Compound Related Data Available

Transcripts for TM4SF4 Gene

mRNA/cDNA for TM4SF4 Gene

Unigene Clusters for TM4SF4 Gene

Transmembrane 4 L six family member 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM4SF4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF4 Gene

No ASD Table

Relevant External Links for TM4SF4 Gene

GeneLoc Exon Structure for
TM4SF4
ECgene alternative splicing isoforms for
TM4SF4

Expression for TM4SF4 Gene

mRNA expression in normal human tissues for TM4SF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF4 Gene

This gene is overexpressed in Liver (x37.3), Pancreas (x8.3), and Small Intestine - Terminal Ileum (x4.8).

Protein differential expression in normal tissues from HIPED for TM4SF4 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TM4SF4 Gene



SOURCE GeneReport for Unigene cluster for TM4SF4 Gene Hs.133527

mRNA Expression by UniProt/SwissProt for TM4SF4 Gene

P48230-T4S4_HUMAN
Tissue specificity: Jejunum and liver
genes like me logo Genes that share expression patterns with TM4SF4: view

Protein tissue co-expression partners for TM4SF4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TM4SF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TM4SF4 35
  • 85.66 (n)
  • 82.26 (a)
TM4SF4 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TM4SF4 35
  • 89.44 (n)
  • 89.6 (a)
TM4SF4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tm4sf4 35
  • 86.8 (n)
  • 87.62 (a)
Tm4sf4 16
Tm4sf4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TM4SF4 35
  • 99.24 (n)
  • 98.86 (a)
TM4SF4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tm4sf4 35
  • 86.8 (n)
  • 87.62 (a)
oppossum
(Monodelphis domestica)
Mammalia TM4SF4 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TM4SF4 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TM4SF4 35
  • 68.65 (n)
  • 70.81 (a)
TM4SF4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TM4SF4 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75723 35
tm4sf4 35
  • 67.49 (n)
  • 71.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia tm4sf4-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3563 35
tm4sf4 35
  • 63.08 (n)
  • 61.29 (a)
tm4sf4 36
  • 62 (a)
OneToOne
Species with no ortholog for TM4SF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF4 Gene

ENSEMBL:
Gene Tree for TM4SF4 (if available)
TreeFam:
Gene Tree for TM4SF4 (if available)

Paralogs for TM4SF4 Gene

Paralogs for TM4SF4 Gene

(4) SIMAP similar genes for TM4SF4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TM4SF4: view

Variants for TM4SF4 Gene

Sequence variations from dbSNP and Humsavar for TM4SF4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9793 -- 149,474,777(+) ATTGG(A/G)GACAA utr-variant-5-prime
rs1317213 -- 149,473,363(-) TAAAT(A/G)TTCTT upstream-variant-2KB
rs1802837 -- 149,475,897(+) GGCTG(C/T)GGGAA synonymous-codon, reference
rs3890113 -- 149,476,254(+) agaac(G/T)tggac intron-variant
rs4131174 -- 149,486,123(-) TGATC(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF4 Gene

Variant ID Type Subtype PubMed ID
esv29983 CNV Gain 17803354
nsv4056 CNV Loss 18451855

Variation tolerance for TM4SF4 Gene

Residual Variation Intolerance Score: 78.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF4 Gene

HapMap Linkage Disequilibrium report
TM4SF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF4 Gene

Disorders for TM4SF4 Gene

Relevant External Links for TM4SF4

Genetic Association Database (GAD)
TM4SF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TM4SF4
genes like me logo Genes that share disorders with TM4SF4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF4 Gene

Publications for TM4SF4 Gene

  1. A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. (PMID: 7665614) Wice B.M. … Gordon J.I. (J. Biol. Chem. 1995) 2 67
  2. TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. (PMID: 25344917) Choi S.I. … Kim I.G. (Oncotarget 2014) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Association of TM4SF4 with the human thiamine transporter-2 in intestinal epithelial cells. (PMID: 24282057) Subramanian V.S. … Said H.M. (Dig. Dis. Sci. 2014) 67
  5. Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo. (PMID: 23296076) Wang L. … Zhao M. (Acta Biochim. Biophys. Sin. (Shanghai) 2013) 67

Products for TM4SF4 Gene

Sources for TM4SF4 Gene

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