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Aliases for TM4SF19 Gene

Aliases for TM4SF19 Gene

  • Transmembrane 4 L Six Family Member 19 2 3 5
  • Osteoclast Maturation-Associated Gene 4 Protein 3 4
  • Tetraspan Membrane Protein OCTM4 3 4
  • OCTM4 3 4
  • Transmembrane 4 L6 Family Member 19 3

External Ids for TM4SF19 Gene

Previous GeneCards Identifiers for TM4SF19 Gene

  • GC03M197508
  • GC03M197531
  • GC03M196042
  • GC03M193348
  • GC03M196049

Summaries for TM4SF19 Gene

Entrez Gene Summary for TM4SF19 Gene

  • The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

GeneCards Summary for TM4SF19 Gene

TM4SF19 (Transmembrane 4 L Six Family Member 19) is a Protein Coding gene. An important paralog of this gene is TM4SF19-TCTEX1D2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF19 Gene

Genomics for TM4SF19 Gene

Regulatory Elements for TM4SF19 Gene

Enhancers for TM4SF19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G196337 1.9 FANTOM5 Ensembl ENCODE dbSUPER 38.5 -0.9 -897 4.4 HDGF PKNOX1 CREB3L1 ARNT SIN3A YY1 ZNF766 FOS PAF1 JUNB TM4SF19 PCYT1A ZDHHC19 SLC51A ACAP2 UBXN7 RNF168 NRROS WDR53 GC03M196342
GH03G196285 1.2 ENCODE 30.8 +51.2 51235 3.2 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 TM4SF19 PCYT1A ACAP2 SLC51A ENSG00000228028 UBXN7 RNU6-910P ENSG00000230732
GH03G196335 1.3 Ensembl ENCODE dbSUPER 24 +2.1 2103 1.2 HDAC1 BRD4 PKNOX1 ATF1 BACH1 POLR2A KDM5B ZNF584 CREM NFE2L2 TM4SF19 TM4SF19-AS1 TM4SF19-TCTEX1D2
GH03G196226 1.3 ENCODE dbSUPER 23.7 +110.6 110591 2.1 HDGF ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF121 GLIS2 TM4SF19 PCYT1A ZDHHC19 SLC51A RNU7-18P RNU6-910P TFRC MUC4 LOC105374304 PIR54915
GH03G196272 1.3 FANTOM5 ENCODE 23 +64.5 64471 3.2 HDAC1 TBP PKNOX1 CBX3 ATF1 CREB3L1 NFIB ZBTB40 YY1 CBX5 PCYT1A TM4SF19 ENSG00000228028 RNU6-910P TCTEX1D2 RNF168 NRROS UBXN7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TM4SF19 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM4SF19 Gene

Chromosome:
3
Start:
196,319,342 bp from pter
End:
196,338,503 bp from pter
Size:
19,162 bases
Orientation:
Minus strand

Genomic View for TM4SF19 Gene

Genes around TM4SF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF19 Gene

Proteins for TM4SF19 Gene

  • Protein details for TM4SF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DZ7-T4S19_HUMAN
    Recommended name:
    Transmembrane 4 L6 family member 19
    Protein Accession:
    Q96DZ7
    Secondary Accessions:
    • B2RV20
    • E9PH22
    • Q336K7

    Protein attributes for TM4SF19 Gene

    Size:
    209 amino acids
    Molecular mass:
    22433 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM4SF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TM4SF19 Gene

Post-translational modifications for TM4SF19 Gene

  • Glycosylation at Asn133
  • Modification sites at PhosphoSitePlus

Other Protein References for TM4SF19 Gene

No data available for DME Specific Peptides for TM4SF19 Gene

Domains & Families for TM4SF19 Gene

Protein Domains for TM4SF19 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TM4SF19 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DZ7

UniProtKB/Swiss-Prot:

T4S19_HUMAN :
  • Belongs to the L6 tetraspanin family.
Family:
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF19: view

No data available for Gene Families for TM4SF19 Gene

Function for TM4SF19 Gene

Phenotypes for TM4SF19 Gene

genes like me logo Genes that share phenotypes with TM4SF19: view

Animal Model Products

CRISPR Products

miRNA for TM4SF19 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF19 Gene

Localization for TM4SF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM4SF19 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TM4SF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TM4SF19: view

Pathways & Interactions for TM4SF19 Gene

SuperPathways for TM4SF19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TM4SF19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TM4SF19 Gene

Drugs & Compounds for TM4SF19 Gene

No Compound Related Data Available

Transcripts for TM4SF19 Gene

Unigene Clusters for TM4SF19 Gene

Transmembrane 4 L six family member 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF19 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for TM4SF19 Gene

GeneLoc Exon Structure for
TM4SF19
ECgene alternative splicing isoforms for
TM4SF19

Expression for TM4SF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TM4SF19 Gene

mRNA differential expression in normal tissues according to GTEx for TM4SF19 Gene

This gene is overexpressed in Adipose - Subcutaneous (x8.0), Testis (x7.4), Minor Salivary Gland (x5.0), and Esophagus - Mucosa (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of TM4SF19 Gene:

TM4SF19

SOURCE GeneReport for Unigene cluster for TM4SF19 Gene:

Hs.733264

Evidence on tissue expression from TISSUES for TM4SF19 Gene

  • Bone(4)
genes like me logo Genes that share expression patterns with TM4SF19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TM4SF19 Gene

Orthologs for TM4SF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM4SF19 34
  • 99.68 (n)
-- 35
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TM4SF19 34
  • 88.46 (n)
-- 35
  • 83 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TM4SF19 34
  • 86.44 (n)
-- 35
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tm4sf19 34 16 35
  • 83.93 (n)
rat
(Rattus norvegicus)
Mammalia Tm4sf19 34
  • 81.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves TM4SF19 35
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC101885866 34
  • 47.93 (n)
zgc:172079 35
  • 29 (a)
ManyToMany
CABZ01033205.2 35
  • 28 (a)
ManyToMany
Species where no ortholog for TM4SF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF19 Gene

ENSEMBL:
Gene Tree for TM4SF19 (if available)
TreeFam:
Gene Tree for TM4SF19 (if available)

Paralogs for TM4SF19 Gene

Variants for TM4SF19 Gene

Sequence variations from dbSNP and Humsavar for TM4SF19 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs147419407 Uncertain significance 196,327,503(+) CCCAG(C/G)AGCAA nc-transcript-variant, reference, missense
rs1000008545 -- 196,331,431(+) GTCTG(C/T)CTCCC intron-variant
rs1000136578 -- 196,338,286(+) AATCA(C/G)AATGG nc-transcript-variant, utr-variant-5-prime
rs1000803125 -- 196,324,768(+) ACCTT(C/T)TGCAC intron-variant, nc-transcript-variant
rs1000875130 -- 196,338,221(+) GGCTA(A/G)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF19 Gene

Variant ID Type Subtype PubMed ID
dgv8849n54 CNV gain 21841781
esv1444129 CNV insertion 17803354
esv2370851 CNV deletion 18987734
esv26108 CNV gain 19812545
esv2677485 CNV deletion 23128226
esv2759213 CNV gain+loss 17122850
esv3563177 CNV deletion 23714750
esv3599281 CNV loss 21293372
esv4542 CNV loss 18987735
nsv1009811 CNV gain 25217958
nsv1074120 CNV deletion 25765185
nsv1136374 CNV deletion 24896259
nsv4183 CNV deletion 18451855
nsv509878 OTHER sequence alteration 20534489
nsv513108 CNV loss 21212237
nsv593071 CNV gain 21841781
nsv593079 CNV loss 21841781
nsv593082 CNV gain+loss 21841781
nsv593083 CNV gain 21841781
nsv593084 CNV gain 21841781
nsv593085 CNV gain+loss 21841781
nsv950311 CNV deletion 24416366
nsv997797 CNV gain 25217958

Variation tolerance for TM4SF19 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF19 Gene

Human Gene Mutation Database (HGMD)
TM4SF19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TM4SF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF19 Gene

Disorders for TM4SF19 Gene

Relevant External Links for TM4SF19

Human Genome Epidemiology (HuGE) Navigator
TM4SF19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TM4SF19

No disorders were found for TM4SF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF19 Gene

Publications for TM4SF19 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64

Products for TM4SF19 Gene

Sources for TM4SF19 Gene

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