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Aliases for TM4SF19 Gene

Aliases for TM4SF19 Gene

  • Transmembrane 4 L Six Family Member 19 2 3 5
  • Osteoclast Maturation-Associated Gene 4 Protein 3 4
  • Tetraspan Membrane Protein OCTM4 3 4
  • OCTM4 3 4
  • Transmembrane 4 L6 Family Member 19 3

External Ids for TM4SF19 Gene

Previous GeneCards Identifiers for TM4SF19 Gene

  • GC03M197508
  • GC03M197531
  • GC03M196042
  • GC03M193348
  • GC03M196049

Summaries for TM4SF19 Gene

GeneCards Summary for TM4SF19 Gene

TM4SF19 (Transmembrane 4 L Six Family Member 19) is a Protein Coding gene. An important paralog of this gene is TM4SF19-TCTEX1D2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF19 Gene

Genomics for TM4SF19 Gene

Regulatory Elements for TM4SF19 Gene

Enhancers for TM4SF19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TM4SF19 on UCSC Golden Path with GeneCards custom track

Promoters for TM4SF19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TM4SF19 Gene

196,319,342 bp from pter
196,338,503 bp from pter
19,162 bases
Minus strand

Genomic View for TM4SF19 Gene

Genes around TM4SF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF19 Gene

Proteins for TM4SF19 Gene

  • Protein details for TM4SF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 19
    Protein Accession:
    Secondary Accessions:
    • B2RV20
    • E9PH22
    • Q336K7

    Protein attributes for TM4SF19 Gene

    209 amino acids
    Molecular mass:
    22433 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM4SF19 Gene


neXtProt entry for TM4SF19 Gene

Post-translational modifications for TM4SF19 Gene

  • Glycosylation at Asn 133
  • Modification sites at PhosphoSitePlus

Other Protein References for TM4SF19 Gene

No data available for DME Specific Peptides for TM4SF19 Gene

Domains & Families for TM4SF19 Gene

Protein Domains for TM4SF19 Gene


Suggested Antigen Peptide Sequences for TM4SF19 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF19: view

No data available for Gene Families for TM4SF19 Gene

Function for TM4SF19 Gene

Phenotypes for TM4SF19 Gene

genes like me logo Genes that share phenotypes with TM4SF19: view

Animal Model Products

CRISPR Products

miRNA for TM4SF19 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF19 Gene

Localization for TM4SF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF19 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM4SF19 Gene COMPARTMENTS Subcellular localization image for TM4SF19 gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TM4SF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with TM4SF19: view

Pathways & Interactions for TM4SF19 Gene

SuperPathways for TM4SF19 Gene

No Data Available

Interacting Proteins for TM4SF19 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000273695 Q96DZ7-T4S19_HUMAN for TM4SF19 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TM4SF19 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF19 Gene

Drugs & Compounds for TM4SF19 Gene

No Compound Related Data Available

Transcripts for TM4SF19 Gene

Unigene Clusters for TM4SF19 Gene

Transmembrane 4 L six family member 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF19 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP4: -
SP5: -

Relevant External Links for TM4SF19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF19 Gene

mRNA expression in normal human tissues for TM4SF19 Gene

mRNA differential expression in normal tissues according to GTEx for TM4SF19 Gene

This gene is overexpressed in Adipose - Subcutaneous (x8.0), Testis (x7.4), Minor Salivary Gland (x5.0), and Esophagus - Mucosa (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of TM4SF19 Gene:


SOURCE GeneReport for Unigene cluster for TM4SF19 Gene:

genes like me logo Genes that share expression patterns with TM4SF19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TM4SF19 Gene

Orthologs for TM4SF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM4SF19 34
  • 88.46 (n)
  • 83.65 (a)
-- 35
  • 83 (a)
(Canis familiaris)
Mammalia TM4SF19 34
  • 86.44 (n)
  • 82.78 (a)
-- 35
  • 83 (a)
(Mus musculus)
Mammalia Tm4sf19 34
  • 83.93 (n)
  • 82.56 (a)
Tm4sf19 16
Tm4sf19 35
  • 79 (a)
(Pan troglodytes)
Mammalia TM4SF19 34
  • 99.68 (n)
  • 99.04 (a)
-- 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Tm4sf19 34
  • 81.63 (n)
  • 77.07 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
(Gallus gallus)
Aves TM4SF19 35
  • 36 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
(Danio rerio)
Actinopterygii LOC101885866 34
  • 47.93 (n)
  • 37.91 (a)
CABZ01033205.2 35
  • 28 (a)
zgc:172079 35
  • 29 (a)
Species where no ortholog for TM4SF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF19 Gene

Gene Tree for TM4SF19 (if available)
Gene Tree for TM4SF19 (if available)

Paralogs for TM4SF19 Gene

Paralogs for TM4SF19 Gene

genes like me logo Genes that share paralogs with TM4SF19: view

Variants for TM4SF19 Gene

Sequence variations from dbSNP and Humsavar for TM4SF19 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_057280 -
VAR_060546 -

Structural Variations from Database of Genomic Variants (DGV) for TM4SF19 Gene

Variant ID Type Subtype PubMed ID
dgv8849n54 CNV gain 21841781
esv1444129 CNV insertion 17803354
esv2370851 CNV deletion 18987734
esv26108 CNV gain 19812545
esv2677485 CNV deletion 23128226
esv2759213 CNV gain+loss 17122850
esv3563177 CNV deletion 23714750
esv3599281 CNV loss 21293372
esv4542 CNV loss 18987735
nsv1009811 CNV gain 25217958
nsv1074120 CNV deletion 25765185
nsv1136374 CNV deletion 24896259
nsv4183 CNV deletion 18451855
nsv509878 OTHER sequence alteration 20534489
nsv513108 CNV loss 21212237
nsv593071 CNV gain 21841781
nsv593079 CNV loss 21841781
nsv593082 CNV gain+loss 21841781
nsv593083 CNV gain 21841781
nsv593084 CNV gain 21841781
nsv593085 CNV gain+loss 21841781
nsv950311 CNV deletion 24416366
nsv997797 CNV gain 25217958

Variation tolerance for TM4SF19 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF19 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF19 Gene

Disorders for TM4SF19 Gene

Relevant External Links for TM4SF19

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM4SF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF19 Gene

Publications for TM4SF19 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 65
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 65

Products for TM4SF19 Gene

Sources for TM4SF19 Gene

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