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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TM4SF19 Gene

protein-coding   GIFtS: 42
GCID: GC03M196042

Transmembrane 4 L Six Family Member 19

  Search for TM4SF19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane 4 L Six Family Member 191 2
Osteoclast Maturation-Associated Gene 4 Protein2 3
Tetraspan Membrane Protein OCTM42 3
Transmembrane 4 L6 Family Member 192

External Ids:    HGNC: 251671   Entrez Gene: 1162112   Ensembl: ENSG000001451077   UniProtKB: Q96DZ73   
ORGUL members:         
NONCODE14:n333431 n410700      

Export aliases for TM4SF19 gene to outside databases

Previous GC identifers: GC03M197508 GC03M197531 GC03M193348


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TM4SF19 Gene: 
TM4SF19 (transmembrane 4 L six family member 19) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is TM4SF4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_029928.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TM4SF19 gene promoter:
         C/EBPbeta   Pbx1a   HSF1 (long)   MyoD   C/EBPalpha   RORalpha1   CHOP-10   POU2F1   POU2F1a   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTM4SF19 promoter sequence
   Search SABiosciences Chromatin IP Primers for TM4SF19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM4SF19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

TM4SF19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TM4SF19 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196042:  view genomic region     (about GC identifiers)

Start:
196,042,953 bp from pter      End:
196,065,374 bp from pter
Size:
22,422 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TM4SF19

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T4S19_HUMAN, Q96DZ7 (See protein sequence)
Recommended Name: Transmembrane 4 L6 family member 19  
Size: 209 amino acids; 22433 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RV20 E9PH22 Q336K7
Alternative splicing: 2 isoforms:  Q96DZ7-1   Q96DZ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TM4SF19: NX_Q96DZ7

Explore proteomics data for TM4SF19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96DZ7

  • TM4SF19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TM4SF19 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001191826.1  NP_001191827.1  NP_612470.2  

    ENSEMBL proteins: 
     ENSP00000405973   ENSP00000395280   ENSP00000414864   ENSP00000387728   ENSP00000273695  

    Human Recombinant Protein Products for TM4SF19: 
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    Cloud-Clone Corp. Proteins for TM4SF19 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TM4SF19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008661 L6_membrane

    Graphical View of Domain Structure for InterPro Entry Q96DZ7

    ProtoNet protein and cluster: Q96DZ7

    1 Blocks protein domain: IPB008661 L6 membrane

    UniProtKB/Swiss-Prot: T4S19_HUMAN, Q96DZ7
    Similarity: Belongs to the L6 tetraspanin family


    TM4SF19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TM4SF19 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TM4SF19 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM4SF19


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TM4SF19

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TM4SF19 (T4S19)

    Search CenterWatch for drugs/clinical trials and news about TM4SF19 / T4S19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TM4SF19 gene (3 alternative transcripts): 
    NM_001204897.1  NM_001204898.1  NM_138461.3  

    Unigene Cluster for TM4SF19:

    Transmembrane 4 L six family member 19
    Hs.733264  [show with all ESTs]
    Unigene Representative Sequence: AK310209
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442633(uc003fwj.3) ENST00000446879(uc010iad.2) ENST00000440822
    ENST00000454715(uc011btv.2) ENST00000273695(uc003fwl.2 uc021xjs.1)

    miRNA
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    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of TM4SF19 
                         Customized lentivirus expression plasmids for stable overexpression of TM4SF19 
    Primer
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    OriGene qPCR primer pairs and template standards for TM4SF19
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    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TM4SF19
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM4SF19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM4SF19

    Additional mRNA sequence: 

    AF192910.1 AK310209.1 BC146985.1 BC146993.1 BC147021.1 BC171824.1 BC171870.1 

    2 DOTS entries:

    DT.100021751  DT.97836557 

    24/76 AceView cDNA sequences (see all 76):

    BE549966 CA950854 AW016718 BX119411 BM311000 BG168937 BU633848 AI380016 
    AI419510 AI633800 BM311591 AA642108 BX098544 CA848186 AA327608 CA772543 
    BC015348 BC013113 AI479561 AA405635 BF061478 BG490753 CA308507 BM808243 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF19 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                            -     -     -                                       
    SP2:                                                                    -           -               
    SP3:                                                                                                
    SP4:                                                                    -                           
    SP5:                    -                                                                           


    ECgene alternative splicing isoforms for TM4SF19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TM4SF19 expression in normal human tissues (normalized intensities)      TM4SF19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAGGATAA
    TM4SF19 Expression
    About this image


    TM4SF19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived early endothelial progenitor cells
     
     Blood (Hematopoietic System)
             Peripheral Blood Immature Myeloid Dendritic Cells   
     
     Uncategorized (Uncategorized)
             PureStem progenitor RP1-MV2-16

    See TM4SF19 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.733264
        SABiosciences Custom PCR Arrays for TM4SF19
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM4SF19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TM4SF19 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tm4sf191 , 5 transmembrane 4 L six family member 191, 5 83.93(n)1
    82.56(a)1
      16 (22.66 cM)5
    2772031  NM_001160402.11  NP_001153874.11 
     324005065 
    chicken
    (Gallus gallus)
    Aves TM4SF191 transmembrane 4 L six family member 19 53.47(n)
    39.06(a)
      424855  XM_422666.3  XP_422666.3 
    lizard
    (Anolis carolinensis)
    Reptilia TM4SF196
    Uncharacterized protein
    42(a)
    1 ↔ 1
    3(30679127-30683090)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-137i24.106
    zgc:1720796
    zgc:172079
    35(a)
    28(a)
    possible ortholog
    possible ortholog
    5(25834076-25843891)
    7(27577743-27583076)


    ENSEMBL Gene Tree for TM4SF19 (if available)
    TreeFam Gene Tree for TM4SF19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TM4SF19 gene
    TM4SF42  TM4SF52  TM4SF182  TM4SF12  
    18/30 SIMAP similar genes for TM4SF19 using alignment to 5 protein entries:     T4S19_HUMAN (see all proteins) (see all similar genes):
    TCTEX1D2    pp12301    KIAA0101    RBP7    SEC14L3    COQ5
    TUBA1C    FP6651    OK/SW-cl.41    HC6    C3orf64    KIAA1651
    SH2B3    GALK2    X-linked retinopathy protein    FP6778    LINC00269    C9orf85

    TM4SF19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in TM4SF19 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0605464
    ----see VAR_0605462 Q P mis40--------
    VAR_0572804
    ----see VAR_0572802 V I mis40--------

    HapMap Linkage Disequilibrium report for TM4SF19 (196042953 - 196065374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for TM4SF19 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv4542CNV Deletion18987735
    esv2726577CNV Deletion23290073
    esv2726578CNV Deletion23290073
    esv2370851CNV Deletion18987734
    esv2677485CNV Deletion23128226
    esv1444129CNV Insertion17803354
    nsv509878CNV Loss20534489
    nsv4183CNV Loss18451855
    nsv878182CNV Loss21882294
    nsv513108CNV Loss21212237


    Human Gene Mutation Database (HGMD): TM4SF19
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TM4SF19 for disorders           About MalaCards

    TM4SF19 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TM4SF19 (1 document)

    Export disorders for TM4SF19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TM4SF19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TM4SF19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116211 HGNC: 25167 AceView: LOC116211 Ensembl:ENSG00000145107 euGenes: HUgn116211
    ECgene: TM4SF19 H-InvDB: TM4SF19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TM4SF19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TM4SF19 gene:
    Search GeneIP for patents involving TM4SF19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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