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Aliases for TM4SF18 Gene

Aliases for TM4SF18 Gene

  • Transmembrane 4 L Six Family Member 18 2 3 5
  • Transmembrane 4 L6 Family Member 18 3
  • L6D 3

External Ids for TM4SF18 Gene

Previous GeneCards Identifiers for TM4SF18 Gene

  • GC03M150520
  • GC03M149036
  • GC03M146407

Summaries for TM4SF18 Gene

GeneCards Summary for TM4SF18 Gene

TM4SF18 (Transmembrane 4 L Six Family Member 18) is a Protein Coding gene. An important paralog of this gene is TM4SF1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF18 Gene

Genomics for TM4SF18 Gene

Regulatory Elements for TM4SF18 Gene

Enhancers for TM4SF18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F149362 0.5 ENCODE 11.7 -28.8 -28751 0.5 ZNF512 SCRT2 HLF CEBPB TM4SF18 TM4SF1 RPS25P5 TM4SF1-AS1
GH03F149365 0.2 ENCODE 11.7 -38.1 -38109 14.3 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 WWTR1-AS1 COMMD2 TM4SF1 TM4SF18 TM4SF1-AS1 RPS25P5
GH03F149297 1.1 Ensembl ENCODE 11.7 +34.4 34447 4.3 PKNOX1 ATF1 ARID4B SIN3A FEZF1 BRCA1 ZNF2 YY1 SLC30A9 ZNF207 COMMD2 TM4SF18 TM4SF1 TM4SF1-AS1 CP CPHL1P
GH03F149355 0.8 ENCODE 11.5 -22.0 -22039 2.4 ELF3 TBP ATF1 MLX ARID4B DMAP1 THRB ZNF48 ZSCAN9 RAD21 TM4SF1 TM4SF1-AS1 TM4SF18 GC03M149358
GH03F149280 0.2 ENCODE 11.5 +52.6 52582 2.6 ZNF316 JUND MAFF CEBPB SUPT20H CEBPG MAFK TM4SF18 CPHL1P WWTR1 ENSG00000244468 LOC101927942
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TM4SF18 on UCSC Golden Path with GeneCards custom track

Promoters for TM4SF18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001376352 1414 1601 SOX13 ZNF316 POLR2A JUN CHD1 MAFK

Genomic Location for TM4SF18 Gene

149,318,498 bp from pter
149,334,414 bp from pter
15,917 bases
Minus strand

Genomic View for TM4SF18 Gene

Genes around TM4SF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF18 Gene

Proteins for TM4SF18 Gene

  • Protein details for TM4SF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 18
    Protein Accession:
    Secondary Accessions:
    • B2R8K0
    • D3DNH5

    Protein attributes for TM4SF18 Gene

    201 amino acids
    Molecular mass:
    22277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TM4SF18 Gene

Post-translational modifications for TM4SF18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TM4SF18 Gene

No data available for DME Specific Peptides for TM4SF18 Gene

Domains & Families for TM4SF18 Gene

Protein Domains for TM4SF18 Gene

Suggested Antigen Peptide Sequences for TM4SF18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF18: view

No data available for Gene Families for TM4SF18 Gene

Function for TM4SF18 Gene

genes like me logo Genes that share phenotypes with TM4SF18: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF18 Gene

Localization for TM4SF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF18 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM4SF18 Gene COMPARTMENTS Subcellular localization image for TM4SF18 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TM4SF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with TM4SF18: view

Pathways & Interactions for TM4SF18 Gene

SuperPathways for TM4SF18 Gene

No Data Available

Interacting Proteins for TM4SF18 Gene

Gene Ontology (GO) - Biological Process for TM4SF18 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF18 Gene

Transcripts for TM4SF18 Gene

Unigene Clusters for TM4SF18 Gene

Transmembrane 4 L six family member 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF18 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for TM4SF18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TM4SF18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF18 Gene

This gene is overexpressed in Spleen (x4.6).

Protein differential expression in normal tissues from HIPED for TM4SF18 Gene

This gene is overexpressed in Bone (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TM4SF18 Gene

Protein tissue co-expression partners for TM4SF18 Gene

NURSA nuclear receptor signaling pathways regulating expression of TM4SF18 Gene:


SOURCE GeneReport for Unigene cluster for TM4SF18 Gene:

genes like me logo Genes that share expression patterns with TM4SF18: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TM4SF18 Gene

Orthologs for TM4SF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM4SF18 34 35
  • 99.83 (n)
(Canis familiaris)
Mammalia TM4SF18 34 35
  • 89.72 (n)
(Bos Taurus)
Mammalia TM4SF18 34 35
  • 88.89 (n)
(Monodelphis domestica)
Mammalia TM4SF18 35
  • 81 (a)
(Gallus gallus)
Aves TM4SF18 34 35
  • 65.01 (n)
(Anolis carolinensis)
Reptilia TM4SF18 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm4sf18 34
  • 60.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3108 34
(Danio rerio)
Actinopterygii tm4sf18 35
  • 36 (a)
Species where no ortholog for TM4SF18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF18 Gene

Gene Tree for TM4SF18 (if available)
Gene Tree for TM4SF18 (if available)

Paralogs for TM4SF18 Gene

Paralogs for TM4SF18 Gene

(3) SIMAP similar genes for TM4SF18 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TM4SF18: view

Variants for TM4SF18 Gene

Sequence variations from dbSNP and Humsavar for TM4SF18 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1045805 -- 149,318,899(-) AAAAA(A/C)CTCAA utr-variant-3-prime
rs1045808 -- 149,318,525(-) TATTA(A/G)AAAAA utr-variant-3-prime
rs10576704 -- 149,332,193(+) ATTGG(-/ATATTA)ATATT intron-variant
rs10576706 -- 149,332,198(+) ATATT(-/AATATT)TTAAA intron-variant
rs111433973 -- 149,322,029(+) TACAA(C/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM4SF18 Gene

Variant ID Type Subtype PubMed ID
nsv998572 CNV loss 25217958

Variation tolerance for TM4SF18 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF18 Gene

Disorders for TM4SF18 Gene

Relevant External Links for TM4SF18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM4SF18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF18 Gene

Publications for TM4SF18 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The L6 membrane proteins--a new four-transmembrane superfamily. (PMID: 10975581) Wright M.D. … Rudy G.B. (Protein Sci. 2000) 2 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for TM4SF18 Gene

Sources for TM4SF18 Gene

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