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Aliases for TM4SF1 Gene

Aliases for TM4SF1 Gene

  • Transmembrane 4 L Six Family Member 1 2 3 5
  • Transmembrane 4 Superfamily Member 1 2 3
  • Tumor-Associated Antigen L6 3 4
  • TAAL6 3 4
  • M3S1 3 4
  • Membrane Component, Chromosome 3, Surface Marker 1 3
  • Membrane Component Chromosome 3 Surface Marker 1 4
  • Transmembrane 4 L6 Family Member 1 3
  • H-L6 3
  • L6 3

External Ids for TM4SF1 Gene

Previous HGNC Symbols for TM4SF1 Gene

  • M3S1

Previous GeneCards Identifiers for TM4SF1 Gene

  • GC03U990049
  • GC03M149971
  • GC03M150368
  • GC03M150407
  • GC03M150569
  • GC03M149086
  • GC03M146458

Summaries for TM4SF1 Gene

Entrez Gene Summary for TM4SF1 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM4SF1 Gene

TM4SF1 (Transmembrane 4 L Six Family Member 1) is a Protein Coding gene. An important paralog of this gene is TM4SF4.

Gene Wiki entry for TM4SF1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF1 Gene

Genomics for TM4SF1 Gene

Regulatory Elements for TM4SF1 Gene

Enhancers for TM4SF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F149338 1.4 FANTOM5 Ensembl ENCODE 17.4 +36.9 36868 5.6 ELF3 TBP SIN3A RAD21 RFX5 ELK1 ZNF366 RCOR1 FOS DEK TM4SF1 TM4SF1-AS1 HPS3 TM4SF18 GC03M149358
GH03F149352 1.1 Ensembl ENCODE 17.5 +25.2 25217 1.1 ELF3 WRNIP1 ARID4B DMAP1 ZNF48 DNMT3B ZNF2 RAD21 YY1 RCOR1 TM4SF1 TM4SF1-AS1 GC03M149358 TM4SF18
GH03F149414 1.1 Ensembl ENCODE 17.1 -37.1 -37145 1.4 ELF3 PKNOX1 RARA ZNF366 CREM HMG20B SP5 CEBPB MIER2 PPARG TM4SF1 TM4SF1-AS1 TM4SF18 LOC105374151 RPL32P8
GH03F149381 1.8 FANTOM5 Ensembl ENCODE 10.2 -8.8 -8797 10.9 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF207 FOS DEK PAF1 TM4SF4 TM4SF18 TM4SF1 COMMD2 ENSG00000243885 LOC105374151
GH03F149355 0.9 ENCODE 16.9 +21.4 21413 2.4 ELF3 TBP ATF1 MLX ARID4B DMAP1 THRB ZNF48 ZSCAN9 RAD21 TM4SF1 TM4SF1-AS1 TM4SF18 GC03M149358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TM4SF1 on UCSC Golden Path with GeneCards custom track

Promoters for TM4SF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001376367 1065 2401 ATF1 ARID4B SIN3A ZNF48 SLC30A9 CBX5 FOS SP5 NFYC JUNB

Genomic Location for TM4SF1 Gene

149,369,018 bp from pter
149,377,865 bp from pter
8,848 bases
Minus strand

Genomic View for TM4SF1 Gene

Genes around TM4SF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF1 Gene

Proteins for TM4SF1 Gene

  • Protein details for TM4SF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 1
    Protein Accession:
    Secondary Accessions:
    • Q6IB51

    Protein attributes for TM4SF1 Gene

    202 amino acids
    Molecular mass:
    21632 Da
    Quaternary structure:
    • Present in high molecular weight complexes in tumor cells.

neXtProt entry for TM4SF1 Gene

Post-translational modifications for TM4SF1 Gene

  • Glycosylation at Asn 129 and Asn 159

Other Protein References for TM4SF1 Gene

Antibody Products

No data available for DME Specific Peptides for TM4SF1 Gene

Domains & Families for TM4SF1 Gene

Protein Domains for TM4SF1 Gene


Suggested Antigen Peptide Sequences for TM4SF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF1: view

No data available for Gene Families for TM4SF1 Gene

Function for TM4SF1 Gene

Molecular function for TM4SF1 Gene

GENATLAS Biochemistry:
transmembrane 4 superfamily member 1,membrane component chromosome 3,cell surface marker 1

Gene Ontology (GO) - Molecular Function for TM4SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TM4SF1: view
genes like me logo Genes that share phenotypes with TM4SF1: view

Animal Model Products

miRNA for TM4SF1 Gene

miRTarBase miRNAs that target TM4SF1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF1 Gene

Localization for TM4SF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM4SF1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TM4SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 7510285
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM4SF1: view

Pathways & Interactions for TM4SF1 Gene

SuperPathways for TM4SF1 Gene

No Data Available

Interacting Proteins for TM4SF1 Gene

Gene Ontology (GO) - Biological Process for TM4SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TM4SF1: view

No data available for Pathways by source and SIGNOR curated interactions for TM4SF1 Gene

Transcripts for TM4SF1 Gene

Unigene Clusters for TM4SF1 Gene

Transmembrane 4 L six family member 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2: - - -
SP3: - - -
SP4: -

Relevant External Links for TM4SF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TM4SF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF1 Gene

This gene is overexpressed in Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for TM4SF1 Gene

This gene is overexpressed in Nasal epithelium (23.2) and Lung (23.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TM4SF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TM4SF1 Gene:


SOURCE GeneReport for Unigene cluster for TM4SF1 Gene:


mRNA Expression by UniProt/SwissProt for TM4SF1 Gene:

Tissue specificity: Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.
genes like me logo Genes that share expression patterns with TM4SF1: view

No data available for Protein tissue co-expression partners for TM4SF1 Gene

Orthologs for TM4SF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM4SF1 34 35
  • 98.51 (n)
(Canis familiaris)
Mammalia TM4SF1 35
  • 90 (a)
(Bos Taurus)
Mammalia TM4SF1 34 35
  • 85.48 (n)
(Ornithorhynchus anatinus)
Mammalia TM4SF1 35
  • 84 (a)
(Rattus norvegicus)
Mammalia Tm4sf1 34
  • 83.33 (n)
(Mus musculus)
Mammalia Tm4sf1 34 16 35
  • 82.84 (n)
(Monodelphis domestica)
Mammalia TM4SF1 35
  • 43 (a)
(Gallus gallus)
Aves TM4SF1 34 35
  • 63.2 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm4sf1 34
  • 68.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18717 34
(Danio rerio)
Actinopterygii tm4sf18 35
  • 48 (a)
Species where no ortholog for TM4SF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF1 Gene

Gene Tree for TM4SF1 (if available)
Gene Tree for TM4SF1 (if available)

Paralogs for TM4SF1 Gene

Paralogs for TM4SF1 Gene

(4) SIMAP similar genes for TM4SF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TM4SF1: view

Variants for TM4SF1 Gene

Sequence variations from dbSNP and Humsavar for TM4SF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1043288 -- 149,369,149(-) GAAGA(A/C)AGATG nc-transcript-variant, utr-variant-3-prime
rs1043289 -- 149,369,145(-) AAAGA(A/T)GGGAA nc-transcript-variant, utr-variant-3-prime
rs10532 -- 149,369,162(+) GCCCA(G/T)TCATC nc-transcript-variant, utr-variant-3-prime
rs10804736 -- 149,379,723(+) GAGGC(C/T)GAGGC intron-variant, upstream-variant-2KB
rs10804737 -- 149,379,836(+) ctgta(A/G)tccca intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TM4SF1 Gene

Variant ID Type Subtype PubMed ID
nsv998572 CNV loss 25217958

Variation tolerance for TM4SF1 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM4SF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM4SF1 Gene

Disorders for TM4SF1 Gene

Relevant External Links for TM4SF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM4SF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF1 Gene

Publications for TM4SF1 Gene

  1. Cloning and expression of the tumor-associated antigen L6. (PMID: 1565644) Marken J.S. … Aruffo A. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody. (PMID: 7510285) Marken J.S. … Aruffo A. (J. Biol. Chem. 1994) 3 4 64
  4. Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. (PMID: 8168850) Virtaneva K.I. … SchrAPder J.P. (Immunogenetics 1994) 3 22 64
  5. Transmembrane-4-L-six-family-1, a potential predictor for poor prognosis, overexpressed in human glioma. (PMID: 25855954) Wang P. … Shi G. (Neuroreport 2015) 3 64

Products for TM4SF1 Gene

Sources for TM4SF1 Gene

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