Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TM4SF1 Gene

Aliases for TM4SF1 Gene

  • Transmembrane 4 L Six Family Member 1 2 3 5
  • Membrane Component Chromosome 3 Surface Marker 1 3 4
  • Transmembrane 4 Superfamily Member 1 2 3
  • Tumor-Associated Antigen L6 3 4
  • TAAL6 3 4
  • M3S1 3 4
  • Membrane Component, Chromosome 3, Surface Marker 1 3
  • H-L6 3
  • L6 3

External Ids for TM4SF1 Gene

Previous HGNC Symbols for TM4SF1 Gene

  • M3S1

Previous GeneCards Identifiers for TM4SF1 Gene

  • GC03U990049
  • GC03M149971
  • GC03M150368
  • GC03M150407
  • GC03M150569
  • GC03M149086
  • GC03M146458

Summaries for TM4SF1 Gene

Entrez Gene Summary for TM4SF1 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM4SF1 Gene

TM4SF1 (Transmembrane 4 L Six Family Member 1) is a Protein Coding gene. An important paralog of this gene is TM4SF19.

Gene Wiki entry for TM4SF1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM4SF1 Gene

Genomics for TM4SF1 Gene

Regulatory Elements for TM4SF1 Gene

Enhancers for TM4SF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TM4SF1 on UCSC Golden Path with GeneCards custom track

Promoters for TM4SF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TM4SF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM4SF1 Gene

149,369,018 bp from pter
149,377,865 bp from pter
8,848 bases
Minus strand

Genomic View for TM4SF1 Gene

Genes around TM4SF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM4SF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM4SF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM4SF1 Gene

Proteins for TM4SF1 Gene

  • Protein details for TM4SF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane 4 L6 family member 1
    Protein Accession:
    Secondary Accessions:
    • Q6IB51

    Protein attributes for TM4SF1 Gene

    202 amino acids
    Molecular mass:
    21632 Da
    Quaternary structure:
    • Present in high molecular weight complexes in tumor cells.

neXtProt entry for TM4SF1 Gene

Proteomics data for TM4SF1 Gene at MOPED

Post-translational modifications for TM4SF1 Gene

  • Glycosylation at Asn 129 and Asn 159

Other Protein References for TM4SF1 Gene

Antibody Products

No data available for DME Specific Peptides for TM4SF1 Gene

Domains & Families for TM4SF1 Gene

Protein Domains for TM4SF1 Gene


Suggested Antigen Peptide Sequences for TM4SF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the L6 tetraspanin family.
  • Belongs to the L6 tetraspanin family.
genes like me logo Genes that share domains with TM4SF1: view

No data available for Gene Families for TM4SF1 Gene

Function for TM4SF1 Gene

Molecular function for TM4SF1 Gene

GENATLAS Biochemistry:
transmembrane 4 superfamily member 1,membrane component chromosome 3,cell surface marker 1
genes like me logo Genes that share phenotypes with TM4SF1: view

Animal Model Products

miRNA for TM4SF1 Gene

miRTarBase miRNAs that target TM4SF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM4SF1 Gene

Localization for TM4SF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM4SF1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM4SF1 Gene COMPARTMENTS Subcellular localization image for TM4SF1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TM4SF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM4SF1: view

Pathways & Interactions for TM4SF1 Gene

SuperPathways for TM4SF1 Gene

No Data Available

Interacting Proteins for TM4SF1 Gene

Gene Ontology (GO) - Biological Process for TM4SF1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM4SF1 Gene

Drugs & Compounds for TM4SF1 Gene

No Compound Related Data Available

Transcripts for TM4SF1 Gene

Unigene Clusters for TM4SF1 Gene

Transmembrane 4 L six family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM4SF1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: -
SP2: - - -
SP3: - - -
SP4: -

Relevant External Links for TM4SF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM4SF1 Gene

mRNA expression in normal human tissues for TM4SF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TM4SF1 Gene

This gene is overexpressed in Minor Salivary Gland (x4.3).

Protein differential expression in normal tissues from HIPED for TM4SF1 Gene

This gene is overexpressed in Nasal epithelium (23.2) and Lung (23.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM4SF1 Gene

SOURCE GeneReport for Unigene cluster for TM4SF1 Gene Hs.351316

mRNA Expression by UniProt/SwissProt for TM4SF1 Gene

Tissue specificity: Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.
genes like me logo Genes that share expression patterns with TM4SF1: view

Primer Products

No data available for Protein tissue co-expression partners for TM4SF1 Gene

Orthologs for TM4SF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TM4SF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM4SF1 35
  • 85.48 (n)
  • 86.14 (a)
TM4SF1 36
  • 86 (a)
(Mus musculus)
Mammalia Tm4sf1 35
  • 82.84 (n)
  • 78.22 (a)
Tm4sf1 16
Tm4sf1 36
  • 78 (a)
(Pan troglodytes)
Mammalia TM4SF1 35
  • 98.51 (n)
  • 97.52 (a)
TM4SF1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tm4sf1 35
  • 83.33 (n)
  • 80.2 (a)
(Canis familiaris)
Mammalia TM4SF1 36
  • 90 (a)
(Monodelphis domestica)
Mammalia TM4SF1 36
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia TM4SF1 36
  • 84 (a)
(Gallus gallus)
Aves TM4SF1 35
  • 63.2 (n)
  • 64.36 (a)
TM4SF1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm4sf1 35
  • 68.16 (n)
  • 73.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18717 35
(Danio rerio)
Actinopterygii tm4sf18 36
  • 48 (a)
Species with no ortholog for TM4SF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TM4SF1 Gene

Gene Tree for TM4SF1 (if available)
Gene Tree for TM4SF1 (if available)

Paralogs for TM4SF1 Gene

Paralogs for TM4SF1 Gene

(4) SIMAP similar genes for TM4SF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TM4SF1: view

Variants for TM4SF1 Gene

Sequence variations from dbSNP and Humsavar for TM4SF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4771 -- 149,375,451(-) AGCAC(C/G/T)GAGGG intron-variant, reference, synonymous-codon
rs8479 -- 149,369,617(-) GGGTA(A/G)TTTAC nc-transcript-variant, utr-variant-3-prime
rs10532 -- 149,369,162(+) GCCCA(G/T)TCATC nc-transcript-variant, utr-variant-3-prime
rs10905 -- 149,369,184(+) TTTTT(A/T)AAACA nc-transcript-variant, utr-variant-3-prime
rs13351 -- 149,369,368(+) ACACA(A/G)GGCAG nc-transcript-variant, utr-variant-3-prime

Variation tolerance for TM4SF1 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.66; 14.07% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TM4SF1 Gene

Disorders for TM4SF1 Gene

Relevant External Links for TM4SF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM4SF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM4SF1 Gene

Publications for TM4SF1 Gene

  1. Cloning and expression of the tumor-associated antigen L6. (PMID: 1565644) Marken J.S. … Aruffo A. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 67
  2. Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins. (PMID: 8168850) Virtaneva K.I. … SchrAPder J.P. (Immunogenetics 1994) 3 23
  3. Transmembrane-4-L-six-family-1, a potential predictor for poor prognosis, overexpressed in human glioma. (PMID: 25855954) Wang P. … Shi G. (Neuroreport 2015) 3
  4. miR-203 inhibits arecoline-induced epitheliala89mesenchymal transition by regulating secreted frizzled-related proteinA 4 and transmembrane-4 L six family member 1 in oral submucous fibrosis. (PMID: 25872484) Zheng L. … Huang L. (Oncol. Rep. 2015) 3
  5. Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells. (PMID: 26241677) Sciuto T.E. … Jaminet S.C. (Biochem. Biophys. Res. Commun. 2015) 3

Products for TM4SF1 Gene

Sources for TM4SF1 Gene