Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TM2D3 Gene

protein-coding   GIFtS: 46
GCID: GC15M102173

TM2 Domain Containing 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TM2 Domain Containing 31 2
BLP22 3 5
Beta-Amyloid-Binding Protein-Like Protein 22 3
BBP-Like Protein 22 3
TM2 Domain-Containing Protein 32

External Ids:    HGNC: 241281   Entrez Gene: 802132   Ensembl: ENSG000001842777   OMIM: 6100145   UniProtKB: Q9BRN93   

Export aliases for TM2D3 gene to outside databases

Previous GC identifers: GC15M100000 GC15M078305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TM2D3 Gene:
The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G
protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid
binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may
have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript
variants of this gene are described but the full length nature of some variants has not been determined. Multiple
polyadenylation sites have been found in this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TM2D3 Gene:
TM2D3 (TM2 domain containing 3) is a protein-coding gene. Diseases associated with TM2D3 include osteoarthritis, and malaria. An important paralog of this gene is TM2D1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TM2D3 gene promoter:
         CUTL1   POU3F2   Cdc5   GATA-2   NF-AT   NF-AT4   NF-AT2   STAT3   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTM2D3 promoter sequence
   Search Chromatin IP Primers for TM2D3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TM2D3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

TM2D3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TM2D3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M102173:  view genomic region     (about GC identifiers)

Start:
102,161,847 bp from pter      End:
102,192,594 bp from pter
Size:
30,748 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TM2D3_HUMAN, Q9BRN9 (See protein sequence)
Recommended Name: TM2 domain-containing protein 3 precursor  
Size: 247 amino acids; 27118 Da
Secondary accessions: B2RDK9 Q9H046 Q9H651
Alternative splicing: 2 isoforms:  Q9BRN9-1   Q9BRN9-2   

Explore the universe of human proteins at neXtProt for TM2D3: NX_Q9BRN9

Explore proteomics data for TM2D3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr46, Asn87, Asn140, Asn157, Asn169
  • Modification sites at PhosphoSitePlus

  • See TM2D3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_079417.2  NP_510883.2  

    ENSEMBL proteins: 
     ENSP00000402179   ENSP00000454131   ENSP00000453990   ENSP00000327584   ENSP00000330433  
     ENSP00000452823   ENSP00000453503   ENSP00000456921  

    TM2D3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TM2D3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TM2D3
    GenScript Custom Purified and Recombinant Proteins Services for TM2D3
    Novus Biologicals TM2D3 Protein
    Novus Biologicals TM2D3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TM2D3

    TM2D3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TM2D3
    Novus Biologicals TM2D3 Antibody
    Abcam antibodies for TM2D3
    Cloud-Clone Corp. Antibodies for TM2D3
    ThermoFisher Antibodies for TM2D3
    LSBio Antibodies in human, mouse, rat for TM2D3

    TM2D3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TM2D3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TM2D3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TM2D3
    Cloud-Clone Corp. CLIAs for TM2D3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007829 TM2

    Graphical View of Domain Structure for InterPro Entry Q9BRN9

    ProtoNet protein and cluster: Q9BRN9

    1 Blocks protein domain: IPB007829 TM2

    UniProtKB/Swiss-Prot: TM2D3_HUMAN, Q9BRN9
    Similarity: Belongs to the TM2 family


    TM2D3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TM2D3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TM2D3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TM2D3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TM2D3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TM2D3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TM2D3:
    hsa-miR-323-3p hsa-miR-493* hsa-miR-27a hsa-miR-513a-5p hsa-miR-548k hsa-miR-205* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTM2D3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TM2D3
    Predesigned siRNA for gene silencing in human, mouse, rat TM2D3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TM2D3

    Clone
    Products:
         
    OriGene clones in human, mouse for TM2D3 (see all 12)
    OriGene ORF clones in mouse, rat for TM2D3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TM2D3 (NM_078474)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TM2D3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TM2D3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TM2D3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TM2D3_HUMAN, Q9BRN9: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TM2D3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TM2D3
    Interactions:

        Search GeneGlobe Interaction Network for TM2D3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TM2D3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TM2D3 gene (2 alternative transcripts): 
    NM_025141.3  NM_078474.2  

    Unigene Cluster for TM2D3:

    TM2 domain containing 3
    Hs.288912  [show with all ESTs]
    Unigene Representative Sequence: BX641093
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560883 ENST00000428002 ENST00000559107(uc010usg.1) ENST00000560390
    ENST00000558129 ENST00000347970(uc002bxj.3) ENST00000559891 ENST00000333202(uc002bxi.3)
    ENST00000561373(uc002bxh.3) ENST00000560013 ENST00000558677 ENST00000559024(uc010ush.1)
    ENST00000560910 ENST00000560212 ENST00000561356
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TM2D3 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TM2D3:
    hsa-miR-323-3p hsa-miR-493* hsa-miR-27a hsa-miR-513a-5p hsa-miR-548k hsa-miR-205* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidTM2D3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TM2D3
    Predesigned siRNA for gene silencing in human, mouse, rat TM2D3
    Clone
    Products:
         
    OriGene clones in human, mouse for TM2D3 (see all 12)
    OriGene ORF clones in mouse, rat for TM2D3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TM2D3 (NM_078474)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TM2D3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TM2D3
    OriGene qSTAR qPCR primer pairs in human, mouse for TM2D3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TM2D3
      QuantiTect SYBR Green Assays in human, mouse, rat TM2D3
      QuantiFast Probe-based Assays in human, mouse, rat TM2D3

    Additional mRNA sequence: 

    AF353992.1 AK026257.1 AK094955.1 AK296553.1 AK297048.1 AK315584.1 AL512689.1 BC006150.1 
    BC008873.2 BX641093.1 

    14 DOTS entries:

    DT.95275822  DT.418656  DT.40108174  DT.121072329  DT.100785212  DT.92434747  DT.75101504  DT.100785213 
    DT.404480  DT.418658  DT.99990931  DT.100785209  DT.75122007  DT.95275825 

    Selected AceView cDNA sequences (see all 301):

    AA331587 AI434889 CA308322 BM791427 AI873307 BQ184351 BE220123 CR605151 
    AI190832 CR591311 AA704531 BM977063 CR615415 AW629002 AI088367 F16283 
    BQ425430 AK094955 CA415979 BI831776 AI862663 AI217682 NM_078474 BQ183492 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TM2D3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                    -           -     -     -                             -     -                           
    SP2:                    -     -     -     -     -                             -     -                           
    SP3:                                                                          -     -                           
    SP4:                    -                                                                                       
    SP5:                    -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for TM2D3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TM2D3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAGTTTT
    TM2D3 Expression
    About this image


    TM2D3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
    TM2D3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TM2D3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288912

    UniProtKB/Swiss-Prot: TM2D3_HUMAN, Q9BRN9
    Tissue specificity: Widely expressed

        Custom PCR Arrays for TM2D3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TM2D3
    OriGene qSTAR qPCR primer pairs in human, mouse for TM2D3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TM2D3
    QuantiTect SYBR Green Assays in human, mouse, rat TM2D3
    QuantiFast Probe-based Assays in human, mouse, rat TM2D3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TM2D3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tm2d31 , 5 TM2 domain containing 31, 5 84.89(n)1
    87.04(a)1
      7 (35.26 cM)5
    686341  NM_178056.31  NP_835157.11 
     656911695 
    chicken
    (Gallus gallus)
    Aves TM2D31 TM2 domain containing 3 73.89(n)
    78.75(a)
      415390  XM_413775.4  XP_413775.3 
    lizard
    (Anolis carolinensis)
    Reptilia TM2D36
    TM2 domain containing 3
    67(a)
    1 ↔ 1
    GL343644.1(8689-15789)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195922 Xenopus laevis transcribed sequence with weak similarity more 80.44(n)    BJ042677.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM533183.12   -- 77.31(n)    BM533183.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta amx1 almondex 56.7(n)
    54.6(a)
      43869  NM_001258662.1  NP_001245591.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C41D11.91 C41D11.9 50.21(n)
    48.1(a)
      266651  NM_058971.1  NP_491372.1 


    ENSEMBL Gene Tree for TM2D3 (if available)
    TreeFam Gene Tree for TM2D3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TM2D3 gene
    TM2D12  

    TM2D3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TM2D3
    PGOHUM00000239535


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TM2D3 (see all 325)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821471591,2
    --102181577(+) GAACTC/GTCACT 2 -- ds50010--------
    rs1123929501,2
    C,F--102181587(+) TCAACT/CAAGAA 2 -- ds50011Minor allele frequency- C:0.09NA 120
    rs1859930401,2
    --102181740(+) ACACAA/CAAGTG 2 -- ds50010--------
    rs1912441581,2
    --102181767(+) TCAGAC/TACCCA 2 -- ds50010--------
    rs1175829241,2
    C,F--102182088(+) TACTCT/CTACCT 2 -- ut311Minor allele frequency- C:0.02NA 120
    rs7083941,2
    C,F,O,A,H--102182183(-) ACATAT/CGTAGT 2 -- ut31 ese324Minor allele frequency- C:0.15MN NA NS EA WA CSA 2402
    rs1455507961,2
    C--102182343(+) AAGGCA/GGACTA 2 -- ut310--------
    rs1510972721,2
    C--102182531(+) TAGTTC/TAGCGT 2 -- ut310--------
    rs1832196081,2
    --102182540(+) GTTTCA/CTTTAT 2 -- ut310--------
    rs1410897791,2
    --102182544(+) CATTTA/GTCTTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TM2D3 (102161847 - 102192594 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TM2D3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2452n71CNV Gain21882294
    nsv528761CNV Gain19592680
    dgv2453n71CNV Gain21882294
    dgv2454n71CNV Gain21882294
    dgv113e55CNV Gain17911159
    nsv457293CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TM2D3
    DNA2.0 Custom Variant and Variant Library Synthesis for TM2D3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610014    OMIM disorders: --

    2 diseases for TM2D3:    
    About MalaCards
    osteoarthritis    malaria


    TM2D3 for disorders           About GeneDecksing


    Export disorders for TM2D3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TM2D3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TM2D3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PubMed id 11278849)1, 2, 3 Kajkowski E.M.... Ozenberger B.A. (J. Biol. Chem. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    7. Cis- and trans-acting gene regulation is associated with osteoarthritis. (PubMed id 16642435)1 Mahr S....MA1ller B. (Am. J. Hum. Genet. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80213 HGNC: 24128 AceView: BLP2 Ensembl:ENSG00000184277 euGenes: HUgn80213
    ECgene: TM2D3 H-InvDB: TM2D3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TM2D3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TM2D3 gene:
    Search GeneIP for patents involving TM2D3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TM2D3  
     OriGene qPCR primer pairs and template standards for TM2D3   OriGene Protein Over-expression Lysate for TM2D3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TM2D3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TM2D3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TM2D3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TM2D3   OriGene Custom Protein Services for TM2D3  

     
     
     Block miRNA regulation of human, mouse, rat TM2D3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TM2D3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TM2D3 Predesigned siRNA for gene silencing in human, mouse, rat TM2D3
     QuantiFast Probe-based Assays in human, mouse, rat TM2D3 QuantiTect SYBR Green Assays in human, mouse, rat TM2D3
     Custom PCR Arrays for TM2D3 Search Chromatin IP Primers for TM2D3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TM2D3  Search GeneGlobe Interaction Network for TM2D3
     Regulatory tfbs in TM2D3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TM2D3 GenScript cDNA clones with any tag delivered in your preferred vector for TM2D3
     GenScript Custom Assay Services for TM2D3 GenScript Custom overexpressing Cell Line Services for TM2D3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TM2D3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TM2D3 antibodies
     TM2D3 proteins
     TM2D3 lysates
     Antibodies for TM2D3
     See all of Abcam's Antibodies, Kits and Proteins for TM2D3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TM2D3
     Antibodies for TM2D3
     ELISAs for TM2D3
     CLIAs for TM2D3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TM2D3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D3
     SwitchGear 3'UTR luciferase reporter plasmids for TM2D3
     SwitchGear Promoter luciferase reporter plasmids for TM2D3
     ThermoFisher Antibodies for TM2D3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TM2D3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TM2D3
     LSBio Antibodies in human, mouse, rat for TM2D3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TM2D3 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4