Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TM2D3 Gene

Aliases for TM2D3 Gene

  • TM2 Domain Containing 3 2 3 5
  • Beta-Amyloid-Binding Protein-Like Protein 2 3 4
  • BBP-Like Protein 2 3 4
  • BLP2 3 4

External Ids for TM2D3 Gene

Previous GeneCards Identifiers for TM2D3 Gene

  • GC15M100000
  • GC15M102173
  • GC15M078305

Summaries for TM2D3 Gene

Entrez Gene Summary for TM2D3 Gene

  • The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM2D3 Gene

TM2D3 (TM2 Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is TM2D1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM2D3 Gene

Genomics for TM2D3 Gene

Regulatory Elements for TM2D3 Gene

Enhancers for TM2D3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TM2D3 on UCSC Golden Path with GeneCards custom track

Promoters for TM2D3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TM2D3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM2D3 Gene

101,621,444 bp from pter
101,652,391 bp from pter
30,948 bases
Minus strand

Genomic View for TM2D3 Gene

Genes around TM2D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM2D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM2D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM2D3 Gene

Proteins for TM2D3 Gene

  • Protein details for TM2D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TM2 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B2RDK9
    • Q9H046
    • Q9H651

    Protein attributes for TM2D3 Gene

    247 amino acids
    Molecular mass:
    27118 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM2D3 Gene


neXtProt entry for TM2D3 Gene

Proteomics data for TM2D3 Gene at MOPED

Post-translational modifications for TM2D3 Gene

  • Glycosylation at Thr 46, Asn 87, Asn 140, Asn 157, and Asn 169
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TM2D3 Gene

Domains & Families for TM2D3 Gene

Protein Domains for TM2D3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TM2 family.
  • Belongs to the TM2 family.
genes like me logo Genes that share domains with TM2D3: view

No data available for Gene Families for TM2D3 Gene

Function for TM2D3 Gene

Phenotypes for TM2D3 Gene

GenomeRNAi human phenotypes for TM2D3:
genes like me logo Genes that share phenotypes with TM2D3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TM2D3 Gene

Localization for TM2D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM2D3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM2D3 Gene COMPARTMENTS Subcellular localization image for TM2D3 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for TM2D3 Gene

Pathways & Interactions for TM2D3 Gene

SuperPathways for TM2D3 Gene

No Data Available

Interacting Proteins for TM2D3 Gene

Gene Ontology (GO) - Biological Process for TM2D3 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM2D3 Gene

Drugs & Compounds for TM2D3 Gene

No Compound Related Data Available

Transcripts for TM2D3 Gene

Unigene Clusters for TM2D3 Gene

TM2 domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM2D3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8: - - - -

Relevant External Links for TM2D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM2D3 Gene

mRNA expression in normal human tissues for TM2D3 Gene

Protein differential expression in normal tissues from HIPED for TM2D3 Gene

This gene is overexpressed in Heart (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TM2D3 Gene

SOURCE GeneReport for Unigene cluster for TM2D3 Gene Hs.288912

mRNA Expression by UniProt/SwissProt for TM2D3 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TM2D3: view

Protein tissue co-expression partners for TM2D3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for TM2D3 Gene

Orthologs for TM2D3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM2D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TM2D3 35
  • 88.39 (n)
  • 93.12 (a)
TM2D3 36
  • 93 (a)
(Mus musculus)
Mammalia Tm2d3 35
  • 84.89 (n)
  • 87.04 (a)
Tm2d3 16
Tm2d3 36
  • 82 (a)
(Pan troglodytes)
Mammalia TM2D3 35
  • 98.65 (n)
  • 98.38 (a)
TM2D3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tm2d3 35
  • 85.56 (n)
  • 86.64 (a)
(Bos Taurus)
Mammalia TM2D3 36
  • 76 (a)
(Monodelphis domestica)
Mammalia TM2D3 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TM2D3 36
  • 74 (a)
(Gallus gallus)
Aves TM2D3 35
  • 73.89 (n)
  • 78.75 (a)
TM2D3 36
  • 74 (a)
(Anolis carolinensis)
Reptilia TM2D3 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3843 35
tm2d3 35
  • 68.73 (n)
  • 69.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19592 35
(Danio rerio)
Actinopterygii tm2d3 35
  • 65.04 (n)
  • 71.2 (a)
tm2d3 36
  • 55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006109 35
  • 56.18 (n)
  • 52.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta amx 35
  • 56.7 (n)
  • 54.6 (a)
amx 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C41D11.9 35
  • 50.21 (n)
  • 48.1 (a)
C41D11.9 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6955 36
  • 70 (a)
Species with no ortholog for TM2D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TM2D3 Gene

Gene Tree for TM2D3 (if available)
Gene Tree for TM2D3 (if available)

Paralogs for TM2D3 Gene

Paralogs for TM2D3 Gene Pseudogenes for TM2D3 Gene

genes like me logo Genes that share paralogs with TM2D3: view

Variants for TM2D3 Gene

Sequence variations from dbSNP and Humsavar for TM2D3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs474596 -- 101,653,141(-) AGACC(A/G)CGGAA upstream-variant-2KB
rs479132 -- 101,635,266(-) TTTCC(A/G)TCTGA intron-variant
rs479913 -- 101,643,133(-) AATAT(A/T)GTTTC intron-variant
rs490687 -- 101,639,170(-) GTAGT(C/G)ATGCT intron-variant
rs498151 -- 101,638,341(-) ctcca(A/G)cctgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM2D3 Gene

Variant ID Type Subtype PubMed ID
nsv457293 CNV Gain 19166990
dgv113e55 CNV Gain 17911159
dgv2452n71 CNV Gain 21882294
dgv2453n71 CNV Gain 21882294
nsv528761 CNV Gain 19592680
dgv2454n71 CNV Gain 21882294

Variation tolerance for TM2D3 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TM2D3 Gene

Disorders for TM2D3 Gene

Relevant External Links for TM2D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM2D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM2D3 Gene

Publications for TM2D3 Gene

  1. Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PMID: 11278849) Kajkowski E.M. … Ozenberger B.A. (J. Biol. Chem. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3
  4. Cis- and trans-acting gene regulation is associated with osteoarthritis. (PMID: 16642435) Mahr S. … MA1ller B. (Am. J. Hum. Genet. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TM2D3 Gene

Sources for TM2D3 Gene