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Aliases for TM2D2 Gene

Aliases for TM2D2 Gene

  • TM2 Domain Containing 2 2 3 5
  • Beta-Amyloid-Binding Protein-Like Protein 1 3 4
  • BBP-Like Protein 1 3 4
  • BLP1 3 4

External Ids for TM2D2 Gene

Previous GeneCards Identifiers for TM2D2 Gene

  • GC08M038968
  • GC08M038846
  • GC08M037379

Summaries for TM2D2 Gene

Entrez Gene Summary for TM2D2 Gene

  • The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM2D2 Gene

TM2D2 (TM2 Domain Containing 2) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM2D2 Gene

Genomics for TM2D2 Gene

Regulatory Elements for TM2D2 Gene

Enhancers for TM2D2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TM2D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TM2D2 Gene

38,988,808 bp from pter
38,996,824 bp from pter
8,017 bases
Minus strand

Genomic View for TM2D2 Gene

Genes around TM2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM2D2 Gene

Proteins for TM2D2 Gene

  • Protein details for TM2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TM2 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RBK4
    • D3DSX8
    • Q8N0X9

    Protein attributes for TM2D2 Gene

    214 amino acids
    Molecular mass:
    22871 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM2D2 Gene


neXtProt entry for TM2D2 Gene

Proteomics data for TM2D2 Gene at MOPED

Post-translational modifications for TM2D2 Gene

No data available for DME Specific Peptides for TM2D2 Gene

Domains & Families for TM2D2 Gene

Protein Domains for TM2D2 Gene


Suggested Antigen Peptide Sequences for TM2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TM2 family.
  • Belongs to the TM2 family.
genes like me logo Genes that share domains with TM2D2: view

No data available for Gene Families for TM2D2 Gene

Function for TM2D2 Gene

Phenotypes for TM2D2 Gene

genes like me logo Genes that share phenotypes with TM2D2: view

Animal Model Products

CRISPR Products

miRNA for TM2D2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM2D2 Gene

Localization for TM2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM2D2 Gene COMPARTMENTS Subcellular localization image for TM2D2 gene
Compartment Confidence
plasma membrane 4
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TM2D2 Gene

Pathways & Interactions for TM2D2 Gene

SuperPathways for TM2D2 Gene

No Data Available

Interacting Proteins for TM2D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9BX73-TM2D2_HUMAN ENSP00000416050 for TM2D2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TM2D2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM2D2 Gene

Drugs & Compounds for TM2D2 Gene

No Compound Related Data Available

Transcripts for TM2D2 Gene

Unigene Clusters for TM2D2 Gene

TM2 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TM2D2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for TM2D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM2D2 Gene

mRNA expression in normal human tissues for TM2D2 Gene

Protein differential expression in normal tissues from HIPED for TM2D2 Gene

This gene is overexpressed in Heart (43.7), Fetal testis (8.7), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM2D2 Gene

SOURCE GeneReport for Unigene cluster for TM2D2 Gene Hs.7471

mRNA Expression by UniProt/SwissProt for TM2D2 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TM2D2: view

Protein tissue co-expression partners for TM2D2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TM2D2 Gene

Orthologs for TM2D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM2D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM2D2 35
  • 89.56 (n)
  • 94.86 (a)
TM2D2 36
  • 95 (a)
(Canis familiaris)
Mammalia TM2D2 35
  • 91.9 (n)
  • 96.26 (a)
TM2D2 36
  • 96 (a)
(Mus musculus)
Mammalia Tm2d2 35
  • 83.72 (n)
  • 91.08 (a)
Tm2d2 16
Tm2d2 36
  • 91 (a)
(Pan troglodytes)
Mammalia TM2D2 35
  • 100 (n)
  • 100 (a)
TM2D2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tm2d2 35
  • 83.88 (n)
  • 90.61 (a)
(Monodelphis domestica)
Mammalia TM2D2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TM2D2 36
  • 75 (a)
(Gallus gallus)
Aves TM2D2 35
  • 70.35 (n)
  • 77.39 (a)
TM2D2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia TM2D2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm2d2 35
  • 66.84 (n)
  • 75 (a)
(Danio rerio)
Actinopterygii Dr.16550 35
tm2d2 35
  • 65.85 (n)
  • 72.68 (a)
tm2d2 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002821 35
  • 58.11 (n)
  • 61.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11103 35
  • 56.43 (n)
  • 57.23 (a)
CG11103 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea C02F5.13 35
  • 54.14 (n)
  • 54.36 (a)
C02F5.13 36
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8437 35
Species with no ortholog for TM2D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TM2D2 Gene

Gene Tree for TM2D2 (if available)
Gene Tree for TM2D2 (if available)

Paralogs for TM2D2 Gene

No data available for Paralogs for TM2D2 Gene

Variants for TM2D2 Gene

Sequence variations from dbSNP and Humsavar for TM2D2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7832975 -- 38,989,632(+) TCTTA(C/T)TTTTT utr-variant-3-prime
rs7836422 -- 38,992,502(+) aaaTA(C/T)GCATT intron-variant
rs7842543 -- 38,989,496(+) TGGGC(A/G)GGGGT utr-variant-3-prime
rs7842732 -- 38,989,660(+) GTAGG(A/G)TTATG utr-variant-3-prime
rs3183442 -- 38,991,238(-) AGACC(C/T)GATGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TM2D2 Gene

Variant ID Type Subtype PubMed ID
nsv820251 CNV Loss 19587683

Variation tolerance for TM2D2 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TM2D2 Gene

Disorders for TM2D2 Gene

Relevant External Links for TM2D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM2D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM2D2 Gene

Publications for TM2D2 Gene

  1. Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PMID: 11278849) Kajkowski E.M. … Ozenberger B.A. (J. Biol. Chem. 2001) 2 3 4 67
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for TM2D2 Gene

Sources for TM2D2 Gene