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Aliases for TM2D2 Gene

Aliases for TM2D2 Gene

  • TM2 Domain Containing 2 2 3
  • BLP1 3 4 6
  • Beta-Amyloid-Binding Protein-Like Protein 1 3 4
  • BBP-Like Protein 1 3 4
  • TM2 Domain-Containing Protein 2 3

External Ids for TM2D2 Gene

Previous GeneCards Identifiers for TM2D2 Gene

  • GC08M038968
  • GC08M038846
  • GC08M037379

Summaries for TM2D2 Gene

Entrez Gene Summary for TM2D2 Gene

  • The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM2D2 Gene

TM2D2 (TM2 Domain Containing 2) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM2D2 Gene

Genomics for TM2D2 Gene

Regulatory Elements for TM2D2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TM2D2 Gene

38,988,808 bp from pter
38,996,824 bp from pter
8,017 bases
Minus strand

Genomic View for TM2D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TM2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM2D2 Gene

Proteins for TM2D2 Gene

  • Protein details for TM2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TM2 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RBK4
    • D3DSX8
    • Q8N0X9

    Protein attributes for TM2D2 Gene

    214 amino acids
    Molecular mass:
    22871 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM2D2 Gene


neXtProt entry for TM2D2 Gene

Proteomics data for TM2D2 Gene at MOPED

Post-translational modifications for TM2D2 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for TM2D2 Gene

Domains for TM2D2 Gene

Protein Domains for TM2D2 Gene


Suggested Antigen Peptide Sequences for TM2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BX73
  • Belongs to the TM2 family.
genes like me logo Genes that share domains with TM2D2: view

No data available for Gene Families for TM2D2 Gene

Function for TM2D2 Gene

Phenotypes for TM2D2 Gene

GenomeRNAi human phenotypes for TM2D2:
genes like me logo Genes that share phenotypes with TM2D2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM2D2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TM2D2 Gene

Localization for TM2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM2D2 Gene COMPARTMENTS Subcellular localization image for TM2D2 gene
Compartment Confidence
plasma membrane 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TM2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM2D2: view

Pathways for TM2D2 Gene

SuperPathways for TM2D2 Gene

No Data Available

Interacting Proteins for TM2D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9BX73-TM2D2_HUMAN ENSP00000416050 for TM2D2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TM2D2 Gene


No data available for Pathways by source for TM2D2 Gene

Transcripts for TM2D2 Gene

Unigene Clusters for TM2D2 Gene

TM2 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM2D2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM2D2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for TM2D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM2D2 Gene

mRNA expression in normal human tissues for TM2D2 Gene

Protein differential expression in normal tissues for TM2D2 Gene

This gene is overexpressed in Heart (43.7), Fetal testis (8.7), and Testis (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TM2D2 Gene

SOURCE GeneReport for Unigene cluster for TM2D2 Gene Hs.7471

mRNA Expression by UniProt/SwissProt for TM2D2 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TM2D2: view

Expression partners for TM2D2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TM2D2 Gene

Orthologs for TM2D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM2D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM2D2 35
  • 89.56 (n)
  • 94.86 (a)
TM2D2 36
  • 95 (a)
(Canis familiaris)
Mammalia TM2D2 35
  • 91.9 (n)
  • 96.26 (a)
TM2D2 36
  • 96 (a)
(Mus musculus)
Mammalia Tm2d2 35
  • 83.72 (n)
  • 91.08 (a)
Tm2d2 16
Tm2d2 36
  • 91 (a)
(Pan troglodytes)
Mammalia TM2D2 35
  • 100 (n)
  • 100 (a)
TM2D2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tm2d2 35
  • 83.88 (n)
  • 90.61 (a)
(Monodelphis domestica)
Mammalia TM2D2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TM2D2 36
  • 75 (a)
(Gallus gallus)
Aves TM2D2 35
  • 70.35 (n)
  • 77.39 (a)
TM2D2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia TM2D2 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm2d2 35
  • 66.84 (n)
  • 75 (a)
(Danio rerio)
Actinopterygii Dr.16550 35
tm2d2 35
  • 65.85 (n)
  • 72.68 (a)
tm2d2 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002821 35
  • 58.11 (n)
  • 61.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11103 35
  • 56.43 (n)
  • 57.23 (a)
CG11103 36
  • 55 (a)
(Caenorhabditis elegans)
Secernentea C02F5.13 35
  • 54.14 (n)
  • 54.36 (a)
C02F5.13 36
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8437 35
Species with no ortholog for TM2D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TM2D2 Gene

Gene Tree for TM2D2 (if available)
Gene Tree for TM2D2 (if available)

Paralogs for TM2D2 Gene

No data available for Paralogs for TM2D2 Gene

Variants for TM2D2 Gene

Sequence variations from dbSNP and Humsavar for TM2D2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3183442 -- 38,991,238(-) AGACC(C/T)GATGT utr-variant-3-prime
rs4412343 -- 38,991,855(+) ggttt(C/T)tgcag intron-variant
rs4733895 -- 38,991,331(+) CTCTT(C/T)TTAGT utr-variant-3-prime
rs4733896 -- 38,992,917(+) TCATA(C/G)TCATA intron-variant
rs4733897 -- 38,993,066(+) GATTT(A/C)TATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM2D2 Gene

Variant ID Type Subtype PubMed ID
nsv820251 CNV Loss 19587683

Relevant External Links for TM2D2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM2D2 Gene

Disorders for TM2D2 Gene

No disorders were found for TM2D2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TM2D2 Gene

Publications for TM2D2 Gene

  1. Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PMID: 11278849) Kajkowski E.M. … Ozenberger B.A. (J. Biol. Chem. 2001) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TM2D2 Gene

Sources for TM2D2 Gene

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