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Aliases for TM2D2 Gene

Aliases for TM2D2 Gene

  • TM2 Domain Containing 2 2 3 5
  • Beta-Amyloid-Binding Protein-Like Protein 1 3 4
  • BBP-Like Protein 1 3 4
  • BLP1 3 4
  • TM2 Domain-Containing Protein 2 3

External Ids for TM2D2 Gene

Previous GeneCards Identifiers for TM2D2 Gene

  • GC08M038968
  • GC08M038846
  • GC08M037379

Summaries for TM2D2 Gene

Entrez Gene Summary for TM2D2 Gene

  • The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively spliced transcript variants which encode two different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TM2D2 Gene

TM2D2 (TM2 Domain Containing 2) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM2D2 Gene

Genomics for TM2D2 Gene

Regulatory Elements for TM2D2 Gene

Enhancers for TM2D2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G039035 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.2 -40.9 -40918 5.3 FOXA2 ATF1 ARNT SIN3A YY1 GATA2 FOS DEK ZNF202 JUNB ADAM32 ADAM9 TM2D2 ENSG00000272128 HTRA4 TACC1 PLEKHA2 GC08M039018 ENSG00000207199
GH08G038966 1.2 Ensembl ENCODE dbSUPER 18.6 +30.3 30268 0.3 CTCF ZNF175 RAD21 RFX5 FOSL1 SMC3 TRIM24 NFE2 ZNF654 TRIM22 TM2D2 ADAM32 PLEKHA2 ADAM9 ENSG00000253645
GH08G038910 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +83.9 83862 4.7 HDGF PKNOX1 YBX1 ZNF2 YY1 ZNF302 ZNF143 ZNF207 FOS DEK DDHD2 IDO1 EIF4EBP1 HTRA4 ENSG00000253645 TM2D2 ADAM9 LOC102723716 PLEKHA2
GH08G038898 1.7 FANTOM5 ENCODE dbSUPER 10.6 +94.6 94630 6.8 HDGF PKNOX1 FOXA2 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF766 ENSG00000253645 HTRA4 TM2D2 ADAM9 PLEKHA2 TACC1 DDHD2 C8orf86
GH08G038941 1.5 Ensembl ENCODE dbSUPER 11.4 +52.8 52797 5.5 HDGF ATF1 PKNOX1 FOXA2 ZNF133 FEZF1 ZNF121 ZNF766 CBX5 SMARCA4 PLEKHA2 ADAM9 TM2D2 ENSG00000253645
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TM2D2 on UCSC Golden Path with GeneCards custom track

Promoters for TM2D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000223772 -876 4601 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766

Genomic Location for TM2D2 Gene

38,988,808 bp from pter
38,996,824 bp from pter
8,017 bases
Minus strand

Genomic View for TM2D2 Gene

Genes around TM2D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TM2D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TM2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM2D2 Gene

Proteins for TM2D2 Gene

  • Protein details for TM2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TM2 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RBK4
    • D3DSX8
    • Q8N0X9

    Protein attributes for TM2D2 Gene

    214 amino acids
    Molecular mass:
    22871 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TM2D2 Gene


neXtProt entry for TM2D2 Gene

Post-translational modifications for TM2D2 Gene

No data available for DME Specific Peptides for TM2D2 Gene

Domains & Families for TM2D2 Gene

Protein Domains for TM2D2 Gene


Suggested Antigen Peptide Sequences for TM2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TM2 family.
  • Belongs to the TM2 family.
genes like me logo Genes that share domains with TM2D2: view

No data available for Gene Families for TM2D2 Gene

Function for TM2D2 Gene

Phenotypes for TM2D2 Gene

genes like me logo Genes that share phenotypes with TM2D2: view

Animal Model Products

CRISPR Products

miRNA for TM2D2 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TM2D2 Gene

Localization for TM2D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM2D2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TM2D2 gene
Compartment Confidence
plasma membrane 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TM2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TM2D2: view

Pathways & Interactions for TM2D2 Gene

SuperPathways for TM2D2 Gene

No Data Available

Interacting Proteins for TM2D2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9BX73-TM2D2_HUMAN ENSP00000416050 for TM2D2 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for TM2D2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TM2D2 Gene

Drugs & Compounds for TM2D2 Gene

No Compound Related Data Available

Transcripts for TM2D2 Gene

Unigene Clusters for TM2D2 Gene

TM2 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM2D2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for TM2D2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM2D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TM2D2 Gene

Protein differential expression in normal tissues from HIPED for TM2D2 Gene

This gene is overexpressed in Heart (43.7), Fetal testis (8.7), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TM2D2 Gene

Protein tissue co-expression partners for TM2D2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TM2D2 Gene:


SOURCE GeneReport for Unigene cluster for TM2D2 Gene:


mRNA Expression by UniProt/SwissProt for TM2D2 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TM2D2 Gene

  • Pancreas(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TM2D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TM2D2 Gene

Orthologs for TM2D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM2D2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TM2D2 34 35
  • 100 (n)
(Canis familiaris)
Mammalia TM2D2 34 35
  • 91.9 (n)
(Bos Taurus)
Mammalia TM2D2 34 35
  • 89.56 (n)
(Rattus norvegicus)
Mammalia Tm2d2 34
  • 83.88 (n)
(Mus musculus)
Mammalia Tm2d2 34 16 35
  • 83.72 (n)
(Monodelphis domestica)
Mammalia TM2D2 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TM2D2 35
  • 75 (a)
(Gallus gallus)
Aves TM2D2 34 35
  • 70.35 (n)
(Anolis carolinensis)
Reptilia TM2D2 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm2d2 34
  • 66.84 (n)
(Danio rerio)
Actinopterygii tm2d2 34 35
  • 65.85 (n)
Dr.16550 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002821 34
  • 58.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11103 34 35
  • 56.43 (n)
(Caenorhabditis elegans)
Secernentea C02F5.13 34 35
  • 54.14 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8437 34
Species where no ortholog for TM2D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TM2D2 Gene

Gene Tree for TM2D2 (if available)
Gene Tree for TM2D2 (if available)

Paralogs for TM2D2 Gene

No data available for Paralogs for TM2D2 Gene

Variants for TM2D2 Gene

Sequence variations from dbSNP and Humsavar for TM2D2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs148707472 Likely benign 38,997,141(+) CCAGT(A/C)CTCGG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs1000030858 -- 38,993,968(+) CAATG(-/CTTTACTTAT)CTTTA intron-variant
rs1000331919 -- 38,996,639(+) CTACT(C/T)CGCCC upstream-variant-2KB, utr-variant-5-prime
rs1000716955 -- 38,996,653(+) GCTTC(C/T)GCTTC upstream-variant-2KB, utr-variant-5-prime
rs1000754451 -- 38,992,500(+) AAAAA(-/T)ACGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TM2D2 Gene

Variant ID Type Subtype PubMed ID
nsv820251 CNV loss 19587683

Variation tolerance for TM2D2 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TM2D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TM2D2 Gene

Disorders for TM2D2 Gene

Relevant External Links for TM2D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TM2D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TM2D2 Gene

Publications for TM2D2 Gene

  1. Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PMID: 11278849) Kajkowski E.M. … Ozenberger B.A. (J. Biol. Chem. 2001) 2 3 4 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TM2D2 Gene

Sources for TM2D2 Gene

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