TM2D2 Gene
protein-coding GIFtS: 44
GCID: GC08M038846
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|
TM2 domain containing 2
| |
Aliases
for TM2D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TM2 Domain Containing 21 2 | | BLP11 2 3 | | Beta-Amyloid-Binding Protein-Like Protein 12 3 | | BBP-Like Protein 12 3 | | TM2 Domain-Containing Protein 22 |
Export aliases for TM2D2 gene to outside databasesPrevious GC identifers: GC08M038968 GC08M037379 |
Summaries
for TM2D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TM2D2:
The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain Gprotein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloidbinding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may haveregulatory roles in cell death or proliferation signal cascades. This gene has multiple alternatively splicedtranscript variants which encode two different isoforms. (provided by RefSeq, Jul 2008)
|
Genomic Views
for TM2D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TM2D2 gene promoter:
HFH-3 SRF AML1a SRF (504 AA) FOXD3 POU3F2 FOXL1 FOXI1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for TM2D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM2D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p11.22 Ensembl cytogenetic band: 8p11.22 HGNC cytogenetic band: 8p11.23TM2D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M038846: view genomic region
(about GC identifiers)
Start:
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38,846,327 bp from pter |
End:
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38,854,343 bp from pter |
Size:
|
8,017 bases |
Orientation:
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minus strand |
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Proteins
for TM2D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM2D2_HUMAN, Q9BX73 (See
protein sequence)Recommended Name: TM2 domain-containing protein 2 precursor Size: 214 amino acids; 22871 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RBK4 D3DSX8 Q8N0X9Alternative splicing: 2 isoforms: Q9BX73-1 Q9BX73-2 Explore the universe of human proteins at neXtProt for TM2D2: NX_Q9BX73
TM2D2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001019551.1 NP_001019552.1 NP_114146.3 NP_510882.1
ENSEMBL proteins: ENSP00000391674 ENSP00000416050 ENSP00000380260 ENSP00000428394 ENSP00000430685 ENSP00000428203 ENSP00000402964
Human Recombinant Protein Products for TM2D2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TM2D2 for ontologies About GeneDecksing
TM2D2 Antibody Products:
Assay Products for TM2D2: |
Protein
Domains /
Families
for TM2D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TM2D2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BX73ProtoNet protein and cluster: Q9BX73 UniProtKB/Swiss-Prot: TM2D2_HUMAN, Q9BX73Similarity: Belongs to the TM2 family |
Function
for TM2D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for TM2D2:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM2D2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM2D2 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): TM2D2 (NM_078473) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM2D2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D2 |
|
Pathways & Interactions
for TM2D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TM2D2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TM2D2 (Q9BX732, 3 ENSP000004160504) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TM2D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TM2D2
Search CenterWatch for drugs/clinical trials and news about TM2D2
|
Transcripts
for TM2D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TM2D2 gene (4 alternative transcripts): NM_001024380.1 NM_001024381.1 NM_031940.3 NM_078473.2 Unigene Cluster for TM2D2: TM2 domain containing 2 Hs.7471 [show with all ESTs]Unigene Representative Sequence: NM_03194011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000456845 ENST00000456397(uc003xmk.3) ENST00000397070 ENST00000522434
ENST00000522142 ENST00000521060 ENST00000524331 ENST00000519186 ENST00000517872
ENST00000520152 ENST00000412303(uc003xml.3 uc003xmm.3 uc003xmn.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM2D2 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM2D2 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): TM2D2 (NM_078473) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TM2D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D2 |
Additional cDNA sequence: AF353991.1 AK075027.1 AK075155.1 AK225093.1 AK314703.1 AL834224.1 BC004878.2 BC109049.1 BC109050.1 9 DOTS entries: DT.95180138 DT.100029304 DT.95180135 DT.100795267 DT.100693099 DT.100795268 DT.120639933 DT.120639938 DT.40221236 24/251 AceView cDNA sequences (see all 251): BM680718 BM747612 CR623886 CR598562 BM718833 AA485026 N31309 BM729218 CB158407 BF196595 CB154858 BQ718114 AA301581 AI816330 CB122153 AW089320 AA873687 BF970034 CA429553 CN482128 AI266123 AW574900 AW404001 AI499344
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TM2D2 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e |
|---|
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| SP1: | | | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TM2D2
|
Expression
for TM2D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TM2D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGGAGATC
About this image
See TM2D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TM2D2
SOURCE GeneReport for Unigene cluster: Hs.7471
UniProtKB/Swiss-Prot: TM2D2_HUMAN, Q9BX73Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for TM2D2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM2D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TM2D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM2D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM2D2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D2 |
Orthologs
for TM2D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TM2D2 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for TM2D2 (if available)
TreeFam Gene Tree for TM2D2 (if available) |
Paralogs
for TM2D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TM2D2 gene
- TM2D32 TM2D12
TM2D2 for paralogs About GeneDecksing
|
Genomic Variants
for TM2D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TM2D2 (38846327 - 38854343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TM2D2
1 CNV: 59472 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM2D2 |
|
Disorders
/ Diseases
for TM2D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TM2D2 for disorders About MalaCards
TM2D2 for disorders About GeneDecksing
OMIM gene information: 610081
OMIM disorders: --
Export disorders for TM2D2 gene to outside databases
|
Publications
for TM2D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TM2D2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TM2D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PubMed id 11278849)1, 2, 3 Kajkowski E.M.... Ozenberger B.A. (2001)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for TM2D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TM2D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TM2D2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TM2D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TM2D2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TM2D2 gene:
Search GeneIP for patents involving TM2D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TM2D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TM2D2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TM2D2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TM2D2 | | | OriGene Protein Over-expression Lysate for TM2D2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TM2D2 | | OriGene 3'-UTR Clone for TM2D2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TM2D2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TM2D2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TM2D2 | | OriGene Custom Protein Services for TM2D2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TM2D2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TM2D2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TM2D2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TM2D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TM2D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TM2D2 |
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| | | | Search Tocris compounds for TM2D2 |
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 | | | TM2D2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TM2D2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D2 |
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