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Aliases for TM2D1 Gene

Aliases for TM2D1 Gene

  • TM2 Domain Containing 1 2 3
  • BBP 3 4 6
  • Beta-Amyloid-Binding Protein 3 4
  • HBBP 3 4
  • TM2 Domain-Containing Protein 1 3

External Ids for TM2D1 Gene

Previous GeneCards Identifiers for TM2D1 Gene

  • GC01M061859
  • GC01M062146
  • GC01M060259

Summaries for TM2D1 Gene

Entrez Gene Summary for TM2D1 Gene

  • The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. [provided by RefSeq, Dec 2008]

GeneCards Summary for TM2D1 Gene

TM2D1 (TM2 Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TM2D3.

UniProtKB/Swiss-Prot for TM2D1 Gene

  • May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TM2D1 Gene

Genomics for TM2D1 Gene

Regulatory Elements for TM2D1 Gene

Genomic Location for TM2D1 Gene

61,681,046 bp from pter
61,725,423 bp from pter
44,378 bases
Minus strand

Genomic View for TM2D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TM2D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TM2D1 Gene

Proteins for TM2D1 Gene

  • Protein details for TM2D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TM2 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NDA8

    Protein attributes for TM2D1 Gene

    207 amino acids
    Molecular mass:
    22327 Da
    Quaternary structure:
    • Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP.

neXtProt entry for TM2D1 Gene

Proteomics data for TM2D1 Gene at MOPED

Post-translational modifications for TM2D1 Gene

No data available for DME Specific Peptides for TM2D1 Gene

Domains for TM2D1 Gene

Protein Domains for TM2D1 Gene


Suggested Antigen Peptide Sequences for TM2D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TM2 family.
  • Belongs to the TM2 family.
genes like me logo Genes that share domains with TM2D1: view

No data available for Gene Families for TM2D1 Gene

Function for TM2D1 Gene

Molecular function for TM2D1 Gene

UniProtKB/Swiss-Prot Function:
May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42.

Gene Ontology (GO) - Molecular Function for TM2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 beta-amyloid binding IBA --
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with TM2D1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM2D1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TM2D1 Gene

Localization for TM2D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TM2D1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TM2D1 Gene COMPARTMENTS Subcellular localization image for TM2D1 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TM2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with TM2D1: view

Pathways for TM2D1 Gene

SuperPathways for TM2D1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for TM2D1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q9BX74-TM2D1_HUMAN ENSP00000360222 for TM2D1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TM2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0097190 apoptotic signaling pathway IBA --
genes like me logo Genes that share ontologies with TM2D1: view

No data available for Pathways by source for TM2D1 Gene

Transcripts for TM2D1 Gene

Unigene Clusters for TM2D1 Gene

TM2 domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TM2D1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TM2D1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -

Relevant External Links for TM2D1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TM2D1 Gene

mRNA expression in normal human tissues for TM2D1 Gene

Protein differential expression in normal tissues for TM2D1 Gene

This gene is overexpressed in Gallbladder (43.9) and Ovary (25.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TM2D1 Gene

SOURCE GeneReport for Unigene cluster for TM2D1 Gene Hs.656790

mRNA Expression by UniProt/SwissProt for TM2D1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TM2D1: view

Expression partners for TM2D1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TM2D1 Gene

Orthologs for TM2D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TM2D1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TM2D1 35
  • 89.27 (n)
  • 90.24 (a)
TM2D1 36
  • 91 (a)
(Canis familiaris)
Mammalia LOC479551 35
  • 91.3 (n)
  • 92.75 (a)
TM2D1 36
  • 92 (a)
(Mus musculus)
Mammalia Tm2d1 35
  • 85.67 (n)
  • 85.51 (a)
Tm2d1 16
Tm2d1 36
  • 85 (a)
(Pan troglodytes)
Mammalia TM2D1 35
  • 99.68 (n)
  • 99.03 (a)
TM2D1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tm2d1 35
  • 84.86 (n)
  • 85.02 (a)
(Monodelphis domestica)
Mammalia TM2D1 36
  • 97 (a)
(Gallus gallus)
Aves TM2D1 35
  • 72.53 (n)
  • 73.87 (a)
TM2D1 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tm2d1 35
  • 68.46 (n)
  • 71.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16476 35
(Danio rerio)
Actinopterygii tm2d1 35
  • 64.86 (n)
  • 71.69 (a)
tm2d1 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007485 35
  • 51.63 (n)
  • 48.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10795 35
  • 50 (n)
  • 46.62 (a)
CG10795 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea Y66D12A.21 35
  • 48.82 (n)
  • 39.35 (a)
Y66D12A.21 36
  • 35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8088 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6883 36
  • 49 (a)
Species with no ortholog for TM2D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TM2D1 Gene

Gene Tree for TM2D1 (if available)
Gene Tree for TM2D1 (if available)

Paralogs for TM2D1 Gene

Paralogs for TM2D1 Gene Pseudogenes for TM2D1 Gene

genes like me logo Genes that share paralogs with TM2D1: view

Variants for TM2D1 Gene

Sequence variations from dbSNP and Humsavar for TM2D1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1064482 -- 61,681,856(-) CTAGA(A/T)TTTAG intron-variant
rs1064484 -- 61,681,846(-) GGTCT(C/T)CCAAA intron-variant
rs1064485 -- 61,681,842(-) TCCCA(A/T)ACATT intron-variant
rs1064486 -- 61,681,786(-) TCAAC(G/T)GTATC intron-variant
rs1064487 -- 61,681,774(-) TTTTG(G/T)ATTAG intron-variant

Relevant External Links for TM2D1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TM2D1 Gene

Disorders for TM2D1 Gene

(1) Novoseek inferred disease relationships for TM2D1 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 50.4 3
genes like me logo Genes that share disorders with TM2D1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for TM2D1 Gene

Publications for TM2D1 Gene

  1. Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PMID: 11278849) Kajkowski E.M. … Ozenberger B.A. (J. Biol. Chem. 2001) 2 3 4
  2. Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. (PMID: 12836168) Lee Y. … Kaang B.-K. (J. Neurosci. Res. 2003) 3 4 23
  3. The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes. (PMID: 12553667) Kirfel G. … Herzog V. (Eur. J. Cell Biol. 2002) 2 3
  4. Real-time PCR quantitation of FE65 a beta-amyloid precursor protein-binding protein after traumatic brain injury in rats. (PMID: 12707777) Iino M. … Matoba R. (Int. J. Legal Med. 2003) 23
  5. Molecular cloning, modeling, and localization of rat type 10 17beta-hydroxysteroid dehydrogenase. (PMID: 11165016) He X.Y. … Yang S.Y. (Mol. Cell. Endocrinol. 2001) 23

Products for TM2D1 Gene

Sources for TM2D1 Gene

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