Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TM2D1 Gene

protein-coding   GIFtS: 47
GCID: GC01M062146

TM2 Domain Containing 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TM2 Domain Containing 11 2
BBP2 3 5
Beta-Amyloid-Binding Protein2 3
hBBP2 3
TM2 Domain-Containing Protein 12

External Ids:    HGNC: 241421   Entrez Gene: 839412   Ensembl: ENSG000001626047   OMIM: 6100805   UniProtKB: Q9BX743   
ORGUL members:         

Export aliases for TM2D1 gene to outside databases

Previous GC identifers: GC01M061859 GC01M060259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TM2D1 Gene:
The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module
related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be
important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative
factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This
protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to
beta-amyloid peptide toxicity through a G protein-regulated program of cell death. (provided by RefSeq, Dec 2008)

GeneCards Summary for TM2D1 Gene:
TM2D1 (TM2 domain containing 1) is a protein-coding gene. Diseases associated with TM2D1 include traumatic brain injury, and brain injury. An important paralog of this gene is TM2D3.

UniProtKB/Swiss-Prot: TM2D1_HUMAN, Q9BX74
Function: May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TM2D1 gene promoter:
         LHX3b/Lhx3b   Elk-1   Nkx2-2   GATA-1   CREB   IRF-2   Pax-3   GATA-6   LHX3a/Lhx3a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTM2D1 promoter sequence
   Search Chromatin IP Primers for TM2D1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TM2D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p32.1

TM2D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TM2D1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M062146:  view genomic region     (about GC identifiers)

Start:
62,146,718 bp from pter      End:
62,191,095 bp from pter
Size:
44,378 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TM2D1_HUMAN, Q9BX74 (See protein sequence)
Recommended Name: TM2 domain-containing protein 1 precursor  
Size: 207 amino acids; 22327 Da
Subunit: Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP
Caution: Was originally (PubMed:11278849) thought to modulate beta-amyloid toxicity by coupling to G protein.
However, PubMed:12836168 showed that this effect is not direct
Secondary accessions: A6NDA8

Explore the universe of human proteins at neXtProt for TM2D1: NX_Q9BX74

Explore proteomics data for TM2D1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn72, Asn87, Asn96

  • See TM2D1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114416.1  
    ENSEMBL proteins: 
     ENSP00000475700   ENSP00000360222   ENSP00000476178   ENSP00000475186   ENSP00000475844  
     ENSP00000475529   ENSP00000475297   ENSP00000294613  

    TM2D1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TM2D1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TM2D1
    GenScript Custom Purified and Recombinant Proteins Services for TM2D1
    Novus Biologicals TM2D1 Protein
    Novus Biologicals TM2D1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TM2D1

    TM2D1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TM2D1
    Novus Biologicals TM2D1 Antibody
    Abcam antibodies for TM2D1
    Cloud-Clone Corp. Antibodies for TM2D1
    ThermoFisher Antibodies for TM2D1
    LSBio Antibodies in human, mouse, rat for TM2D1

    TM2D1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TM2D1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TM2D1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TM2D1
    Cloud-Clone Corp. CLIAs for TM2D1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007829 TM2

    Graphical View of Domain Structure for InterPro Entry Q9BX74

    ProtoNet protein and cluster: Q9BX74

    UniProtKB/Swiss-Prot: TM2D1_HUMAN, Q9BX74
    Similarity: Belongs to the TM2 family


    TM2D1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM2D1_HUMAN, Q9BX74
    Function: May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding ----
    GO:0004930G-protein coupled receptor activity ----
         
    TM2D1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tm2d1 (no phenotypes)

    TM2D1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TM2D1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TM2D1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TM2D1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TM2D1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TM2D1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TM2D1:
    hsa-miR-3662 hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidTM2D1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TM2D1
    Predesigned siRNA for gene silencing in human, mouse, rat TM2D1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TM2D1

    Clone
    Products:
         
    OriGene clones in human, mouse for TM2D1 (see all 7)
    OriGene ORF clones in mouse, rat for TM2D1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TM2D1 (NM_032027)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TM2D1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TM2D1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TM2D1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TM2D1_HUMAN, Q9BX74: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane ----
    GO:0016021integral component of membrane IEA--

    TM2D1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including TM2D1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TM2D1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for TM2D1 (Q9BX743 ENSP000003602224) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673, ENSP000002849814I2D: score=2 STRING: ENSP00000284981
    FAM212BQ9NTI73I2D: score=1 
    ARTNENSP000003919984STRING: ENSP00000391998
    CTNNBIP1ENSP000003664664STRING: ENSP00000366466
    ENSG00000225073ENSP000004003264STRING: ENSP00000400326
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0097190apoptotic signaling pathway ----

    TM2D1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TM2D1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TM2D1 gene: 
    NM_032027.2  

    Unigene Cluster for TM2D1:

    TM2 domain containing 1
    Hs.656790  [show with all ESTs]
    Unigene Representative Sequence: AK311444
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000606498 ENST00000472357 ENST00000371180 ENST00000488206 ENST00000472989
    ENST00000488410 ENST00000468586 ENST00000371178 ENST00000494926 ENST00000496465
    ENST00000371177 ENST00000294613(uc001czz.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TM2D1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TM2D1:
    hsa-miR-3662 hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidTM2D1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TM2D1
    Predesigned siRNA for gene silencing in human, mouse, rat TM2D1
    Clone
    Products:
         
    OriGene clones in human, mouse for TM2D1 (see all 7)
    OriGene ORF clones in mouse, rat for TM2D1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TM2D1 (NM_032027)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TM2D1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TM2D1
    OriGene qSTAR qPCR primer pairs in human, mouse for TM2D1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TM2D1
      QuantiTect SYBR Green Assays in human, mouse, rat TM2D1
      QuantiFast Probe-based Assays in human, mouse, rat TM2D1

    Additional mRNA sequence: 

    AF353990.1 AK311444.1 AK311705.1 BC029486.1 BC048995.1 

    12 DOTS entries:

    DT.452370  DT.121375460  DT.92429688  DT.40121277  DT.121375478  DT.92429679  DT.95278078  DT.100783510 
    DT.121375464  DT.99936501  DT.121375491  DT.97765281 

    Selected AceView cDNA sequences (see all 197):

    BX108300 BE467235 AI373710 BC029486 BU664262 BQ690531 CA415155 BQ001515 
    CA417481 AI903938 AW182809 CA418546 AI349520 BF968960 AI350984 AA252976 
    CB305898 BI324832 BU737334 AI299154 NM_032027 AI245878 BQ876648 AI903940 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TM2D1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                                -     -                             -     -           -     -     -                     
    SP2:                                            -                       -     -                                             
    SP3:                                      -     -                       -     -                                             
    SP4:                                -     -                                                                                 
    SP5:                                -     -                             -     -                                             


    ECgene alternative splicing isoforms for TM2D1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TM2D1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TM2D1 Expression
    About this image

    TM2D1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TM2D1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656790

    UniProtKB/Swiss-Prot: TM2D1_HUMAN, Q9BX74
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including TM2D1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TM2D1
    OriGene qSTAR qPCR primer pairs in human, mouse for TM2D1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TM2D1
    QuantiTect SYBR Green Assays in human, mouse, rat TM2D1
    QuantiFast Probe-based Assays in human, mouse, rat TM2D1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TM2D1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tm2d11 , 5 TM2 domain containing 11, 5 85.67(n)1
    85.51(a)1
      4 (45.60 cM)5
    940431  NM_053157.21  NP_444387.11 
     983553705 
    chicken
    (Gallus gallus)
    Aves TM2D11 TM2 domain containing 1 72.53(n)
    73.87(a)
      775978  XM_001235552.3  XP_001235553.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.164762 Xenopus laevis transcribed sequence with moderate similarity more 77.95(n)    BJ036034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tm2d11 TM2 domain containing 1 64.86(n)
    71.69(a)
      100093710  NM_001099263.1  NP_001092733.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG107951 CG10795 50(n)
    46.62(a)
      37443  NM_137739.2  NP_611583.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y66D12A.211 Y66D12A.21 48.82(n)
    39.35(a)
      176581  NM_067080.3  NP_499481.2 


    ENSEMBL Gene Tree for TM2D1 (if available)
    TreeFam Gene Tree for TM2D1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TM2D1 gene
    TM2D32  
    Selected SIMAP similar genes for TM2D1 using alignment to 7 protein entries:     TM2D1_HUMAN (see all proteins) (see all similar genes):
    HBP1    TM4SF19    LSM12    UBXN4    TNNT1    EIF3G
    MUC20    SEPSECS    PPIL6    DOCK8    ARIH1    ZNF28
    LINC00999    ASCC1    CALCOCO2    ZNF257    CLTA    DYNC2LI1

    TM2D1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TM2D1
    PGOHUM00000237701


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TM2D1 (see all 969)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854125891,2
    --62146219(+) AAATCA/GGTGCT 1 -- ds50010--------
    rs1894223711,2
    --62146370(+) ACTGCA/GGTGAG 1 -- ds50010--------
    rs112078081,2
    C,F,A,H--62146438(+) AGGAAG/AAAGTT 1 -- ds500128Minor allele frequency- A:0.34NA NS EA WA CSA 2490
    rs1480262101,2
    --62146522(+) TTTAGC/TTCCCT 1 -- ds50010--------
    rs1417417681,2
    C--62146602(+) CCCCAG/TGCAAT 1 -- ds50010--------
    rs758445591,2
    C,F--62146649(+) TTGAAG/AGATCA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1472009541,2
    C--62146662(+) ATGGGC/TAAGAC 1 -- ds50010--------
    rs412894201,2
    --62146778(+) CCTTTC/GTAAAA 1 -- ut310--------
    rs595624571,2
    C--62146788(+) AGATT-/AAAGAGT 1 -- ut310--------
    rs767949161,2
    C,F--62146961(+) ATGAAA/TAAGAG 1 -- ut312Minor allele frequency- T:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for TM2D1 (62146718 - 62191095 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TM2D1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TM2D1
    DNA2.0 Custom Variant and Variant Library Synthesis for TM2D1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610080    OMIM disorders: --

    6 diseases for TM2D1:    
    About MalaCards
    traumatic brain injury    brain injury    hypospadias    alzheimer's disease
    neuronitis    malaria


    TM2D1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for TM2D1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 50.4 3 19376274 (1), 20477378 (1), 10760475 (1)


    Export disorders for TM2D1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TM2D1 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TM2D1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. (PubMed id 11278849)1, 2, 3 Kajkowski E.M.... Ozenberger B.A. (J. Biol. Chem. 2001)
    2. Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. (PubMed id 12836168)1, 2, 9 Lee Y.... Kaang B.-K. (J. Neurosci. Res. 2003)
    3. The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes. (PubMed id 12553667)1, 3 Kirfel G....Herzog V. (Eur. J. Cell Biol. 2002)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. (PubMed id 15126508)1 Cam J.A....Bu G. (J. Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 83941 HGNC: 24142 AceView: BBP Ensembl:ENSG00000162604 euGenes: HUgn83941
    ECgene: TM2D1 H-InvDB: TM2D1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TM2D1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TM2D1 gene:
    Search GeneIP for patents involving TM2D1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TM2D1  
     OriGene qPCR primer pairs and template standards for TM2D1   OriGene Protein Over-expression Lysate for TM2D1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TM2D1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TM2D1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TM2D1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TM2D1   OriGene Custom Protein Services for TM2D1  

     
     
     Block miRNA regulation of human, mouse, rat TM2D1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TM2D1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TM2D1 Predesigned siRNA for gene silencing in human, mouse, rat TM2D1
     QuantiFast Probe-based Assays in human, mouse, rat TM2D1 QuantiTect SYBR Green Assays in human, mouse, rat TM2D1
     PCR Arrays including human, mouse, rat TM2D1 Search Chromatin IP Primers for TM2D1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TM2D1  GeneGlobe Interaction Network for TM2D1
     Regulatory tfbs in TM2D1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TM2D1 GenScript cDNA clones with any tag delivered in your preferred vector for TM2D1
     GenScript Custom Assay Services for TM2D1 GenScript Custom overexpressing Cell Line Services for TM2D1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TM2D1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TM2D1 antibodies
     TM2D1 proteins
     TM2D1 lysates
     Antibodies for TM2D1
     See all of Abcam's Antibodies, Kits and Proteins for TM2D1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TM2D1
     Antibodies for TM2D1
     ELISAs for TM2D1
     CLIAs for TM2D1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TM2D1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TM2D1
     SwitchGear 3'UTR luciferase reporter plasmids for TM2D1
     SwitchGear Promoter luciferase reporter plasmids for TM2D1
     ThermoFisher Antibodies for TM2D1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TM2D1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TM2D1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TM2D1
     LSBio Antibodies in human, mouse, rat for TM2D1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TM2D1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4