Aliases for TLX3 Gene
External Ids for TLX3 Gene
Previous HGNC Symbols for TLX3 Gene
Previous GeneCards Identifiers for TLX3 Gene
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008]
GeneCards Summary for TLX3 Gene
TLX3 (T-Cell Leukemia Homeobox 3) is a Protein Coding gene. Diseases associated with TLX3 include precursor t-cell acute lymphoblastic leukemia and t-cell leukemia. Among its related pathways are Transcriptional misregulation in cancer and SIDS Susceptibility Pathways. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NKX2-5.