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Aliases for TLX3 Gene

Aliases for TLX3 Gene

  • T-Cell Leukemia Homeobox 3 2 3 5
  • T-Cell Leukemia, Homeobox 3 2 3
  • Homeobox Protein Hox-11L2 3 4
  • Homeo Box 11-Like 2 2 3
  • HOX11L2 3 4
  • RNX 3

External Ids for TLX3 Gene

Previous HGNC Symbols for TLX3 Gene

  • HOX11L2

Previous GeneCards Identifiers for TLX3 Gene

  • GC05P170971
  • GC05P171438
  • GC05P170671
  • GC05P170717
  • GC05P170668
  • GC05P170736
  • GC05P165834

Summaries for TLX3 Gene

Entrez Gene Summary for TLX3 Gene

  • The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]

GeneCards Summary for TLX3 Gene

TLX3 (T-Cell Leukemia Homeobox 3) is a Protein Coding gene. Diseases associated with TLX3 include precursor t-cell acute lymphoblastic leukemia and t-cell leukemia. Among its related pathways are SIDS Susceptibility Pathways and Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is BARX2.

Gene Wiki entry for TLX3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX3 Gene

Genomics for TLX3 Gene

Regulatory Elements for TLX3 Gene

Promoters for TLX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLX3 Gene

Chromosome:
5
Start:
171,309,284 bp from pter
End:
171,312,134 bp from pter
Size:
2,851 bases
Orientation:
Plus strand

Genomic View for TLX3 Gene

Genes around TLX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX3 Gene

Proteins for TLX3 Gene

  • Protein details for TLX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43711-TLX3_HUMAN
    Recommended name:
    T-cell leukemia homeobox protein 3
    Protein Accession:
    O43711
    Secondary Accessions:
    • Q96AD3

    Protein attributes for TLX3 Gene

    Size:
    291 amino acids
    Molecular mass:
    31867 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLX3 Gene

Proteomics data for TLX3 Gene at MOPED

Post-translational modifications for TLX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TLX3 Gene

Domains & Families for TLX3 Gene

Gene Families for TLX3 Gene

Protein Domains for TLX3 Gene

Suggested Antigen Peptide Sequences for TLX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43711

UniProtKB/Swiss-Prot:

TLX3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with TLX3: view

Function for TLX3 Gene

Gene Ontology (GO) - Molecular Function for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TLX3: view
genes like me logo Genes that share phenotypes with TLX3: view

Animal Models for TLX3 Gene

MGI Knock Outs for TLX3:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLX3 Gene

Localization for TLX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLX3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLX3 Gene COMPARTMENTS Subcellular localization image for TLX3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for TLX3 Gene

Pathways & Interactions for TLX3 Gene

genes like me logo Genes that share pathways with TLX3: view

Pathways by source for TLX3 Gene

1 BioSystems pathway for TLX3 Gene
1 KEGG pathway for TLX3 Gene

Gene Ontology (GO) - Biological Process for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007417 central nervous system development IEA --
GO:0030182 neuron differentiation IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with TLX3: view

No data available for SIGNOR curated interactions for TLX3 Gene

Drugs & Compounds for TLX3 Gene

No Compound Related Data Available

Transcripts for TLX3 Gene

mRNA/cDNA for TLX3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLX3 Gene

T-cell leukemia homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLX3 Gene

No ASD Table

Relevant External Links for TLX3 Gene

GeneLoc Exon Structure for
TLX3
ECgene alternative splicing isoforms for
TLX3

Expression for TLX3 Gene

mRNA expression in normal human tissues for TLX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLX3 Gene

This gene is overexpressed in Brain - Cerebellum (x25.5) and Brain - Cerebellar Hemisphere (x23.4).

SOURCE GeneReport for Unigene cluster for TLX3 Gene Hs.249125

genes like me logo Genes that share expression patterns with TLX3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TLX3 Gene

Orthologs for TLX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLX3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLX3 35
  • 95.42 (n)
  • 98.97 (a)
TLX3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLX3 35
  • 96.11 (n)
  • 99.66 (a)
TLX3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlx3 35
  • 95.19 (n)
  • 99.66 (a)
Tlx3 16
Tlx3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlx3 35
  • 95.53 (n)
  • 99.66 (a)
oppossum
(Monodelphis domestica)
Mammalia TLX3 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLX3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLX3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLX3 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLX3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlx3 35
  • 74.13 (n)
  • 84.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia tlx3-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii tlx3b 35
  • 68.36 (n)
  • 74.28 (a)
CABZ01067175.1 36
  • 68 (a)
OneToMany
tlx3b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta C15 37
  • 67 (a)
C15 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cog-1 36
  • 23 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for TLX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLX3 Gene

ENSEMBL:
Gene Tree for TLX3 (if available)
TreeFam:
Gene Tree for TLX3 (if available)

Paralogs for TLX3 Gene

(2) SIMAP similar genes for TLX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TLX3: view

Variants for TLX3 Gene

Sequence variations from dbSNP and Humsavar for TLX3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs918472 -- 171,311,832(+) GGCCC(A/G)GGCCT utr-variant-3-prime
rs966056 -- 171,310,655(+) CCTCC(A/C)ACTCT intron-variant
rs971007 -- 171,310,957(+) ACAGG(A/C)CCTGG intron-variant
rs1366433 -- 171,308,329(+) TTGCT(C/T)TAGGA upstream-variant-2KB
rs2303742 -- 171,309,470(+) GCCCC(A/G)CGGGG reference, synonymous-codon

Variation tolerance for TLX3 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLX3 Gene

HapMap Linkage Disequilibrium report
TLX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLX3 Gene

Disorders for TLX3 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TLX3 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
t-cell leukemia
  • leukemia t-cell
leukemia
lymphoblastic leukemia
  • acute lymphocytic leukemia
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TLX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLX3

Genetic Association Database (GAD)
TLX3
Human Genome Epidemiology (HuGE) Navigator
TLX3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLX3
genes like me logo Genes that share disorders with TLX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLX3 Gene

Publications for TLX3 Gene

  1. Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping. (PMID: 11435718) Lee-Kirsch M.A. … Gahr M. (Cytogenet. Cell Genet. 2001) 2 3 23 67
  2. Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. (PMID: 18368072) Baak U. … Burmeister T. (Leukemia 2008) 3 23
  3. Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. (PMID: 15334547) Su X.Y. … Bernard O.A. (Genes Chromosomes Cancer 2004) 3 23
  4. t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe FranAsais de CytogAcnActique HAcmatologique (GFCH). (PMID: 12970786) Berger R. … Bernard O.A. (Leukemia 2003) 3 23
  5. Mutational analysis of the RNX gene in congenital central hypoventilation syndrome. (PMID: 12407709) Matera I. … Ceccherini I. (Am. J. Med. Genet. 2002) 3 23

Products for TLX3 Gene

Sources for TLX3 Gene

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