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TLX3 Gene

protein-coding   GIFtS: 54
GCID: GC05P170736

T-Cell Leukemia Homeobox 3

(Previous names: homeo box 11-like 2, T-cell leukemia, homeobox 3)
(Previous symbol: HOX11L2)
  See TLX3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Cell Leukemia Homeobox 31 2     Homeobox Protein Hox-11L22 3
HOX11L21 2 3 5     RNX2 5
Homeo Box 11-Like 21 2     T-Cell Leukemia Homeobox Protein 32
T-Cell Leukemia, Homeobox 31 2     

External Ids:    HGNC: 135321   Entrez Gene: 300122   Ensembl: ENSG000001644387   OMIM: 6046405   UniProtKB: O437113   

Export aliases for TLX3 gene to outside databases

Previous GC identifers: GC05P170971 GC05P171438 GC05P170671 GC05P170717 GC05P170668 GC05P165834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLX3 Gene:
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription
factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly
conserved homeodomain (Dear et al., 1993 (PubMed 8099440)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TLX3 Gene:
TLX3 (T-cell leukemia homeobox 3) is a protein-coding gene. Diseases associated with TLX3 include t-cell leukemia, and congenital central hypoventilation syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

Gene Wiki entry for TLX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLX3 gene promoter:
         AP-2beta   Nkx2-5   AP-2alpha   AP-2gamma   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLX3 promoter sequence
   Search Chromatin IP Primers for TLX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

TLX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLX3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P170736:  view genomic region     (about GC identifiers)

Start:
170,736,288 bp from pter      End:
170,739,138 bp from pter
Size:
2,851 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TLX3_HUMAN, O43711 (See protein sequence)
Recommended Name: T-cell leukemia homeobox protein 3  
Size: 291 amino acids; 31867 Da
Secondary accessions: Q96AD3

Explore the universe of human proteins at neXtProt for TLX3: NX_O43711

Explore proteomics data for TLX3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TLX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066305.2  
    ENSEMBL proteins: 
     ENSP00000296921  

    TLX3 Human Recombinant Protein Products:

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    Novus Biologicals TLX3 Proteins
    Novus Biologicals TLX3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLX3

     
    Search eBioscience for Proteins for TLX3 

     
    antibodies-online proteins for TLX3 (7 products) 

     
    antibodies-online peptides for TLX3

    TLX3 Antibody Products:

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    antibodies-online antibodies for TLX3 (30 products) 

    TLX3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLX3
    Cloud-Clone Corp. CLIAs for TLX3
    Search eBioscience for ELISAs for TLX3 
    antibodies-online kits for TLX3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR020479 Homeobox_metazoa
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O43711

    ProtoNet protein and cluster: O43711

    UniProtKB/Swiss-Prot: TLX3_HUMAN, O43711
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with TLX3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with TLX3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TLX3:
     Decreased viability  Decreased viability of wild-ty 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tlx3):
     behavior/neurological  digestive/alimentary  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with TLX3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tlx3tm1Sjk for TLX3

       genOway: Develop your customized and physiologically relevant rodent model for TLX3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TLX3:
    hsa-mir-335-5p (MIRT018007), hsa-mir-26b-5p (MIRT029503)

    Block miRNA regulation of human, mouse, rat TLX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLX3 (see all 14):
    hsa-miR-4271 hsa-miR-520d-5p hsa-miR-191 hsa-miR-548k hsa-miR-3133 hsa-miR-548l hsa-miR-1538 hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TLX3
    Predesigned siRNA for gene silencing in human, mouse, rat TLX3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TLX3

    Clone
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    OriGene clones in human, mouse for TLX3 (see all 5)
    OriGene ORF clones in mouse, rat for TLX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLX3 (NM_021025)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TLX3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLX3_HUMAN, O43711: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with TLX3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLX3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways


    Find genes that share SuperPaths with TLX3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TLX3
        SIDS Susceptibility Pathways


    1 Kegg Pathway  (Kegg details for TLX3):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLX3: 
              Stem Cell Transcription Factors in human mouse rat
              Leukemia in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TLX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLX3 (O437111, 3 ENSP000002969214) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    ING4Q9UNL43, ENSP000003800244I2D: score=1 STRING: ENSP00000380024
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    HNRNPUL1Q9BUJ23, ENSP000003758634I2D: score=1 STRING: ENSP00000375863
    IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
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    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001708cell fate specification ----
    GO:0001764neuron migration IEA--
    GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007417central nervous system development IEA--

    Find genes that share ontologies with TLX3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLX3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLX3 gene: 
    NM_021025.2  

    Unigene Cluster for TLX3:

    T-cell leukemia homeobox 3
    Hs.249125  [show with all ESTs]
    Unigene Representative Sequence: NM_021025
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296921(uc003mbf.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TLX3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLX3 (see all 14):
    hsa-miR-4271 hsa-miR-520d-5p hsa-miR-191 hsa-miR-548k hsa-miR-3133 hsa-miR-548l hsa-miR-1538 hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TLX3
    Predesigned siRNA for gene silencing in human, mouse, rat TLX3
    Clone
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    OriGene ORF clones in mouse, rat for TLX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLX3 (NM_021025)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX3
    Primer
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    OriGene qPCR primer pairs and template standards for TLX3
    OriGene qSTAR qPCR primer pairs in human, mouse for TLX3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLX3
      QuantiTect SYBR Green Assays in human, mouse, rat TLX3
      QuantiFast Probe-based Assays in human, mouse, rat TLX3

    Additional mRNA sequence: BC017291.2 

    1 DOTS entry:

    DT.75180880 

    8 AceView cDNA sequences:

    NM_021025 BC017291 BG828093 AJ713910 BX283981 AI202136 AJ714712 R88463 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAGCTGC
    TLX3 Expression
    About this image


    TLX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Pons
             Midbrain   
    TLX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249125
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLX3: 
              Stem Cell Transcription Factors in human mouse rat
              Leukemia in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLX3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlx31 , 5 T cell leukemia, homeobox 31, 5 95.19(n)1
    99.66(a)1
      11 (19.21 cM)5
    271401  NM_019916.21  NP_064300.21 
     332007525 
    chicken
    (Gallus gallus)
    Aves TLX36
    T-cell leukemia homeobox protein 3
    97(a)
    1 ↔ 1
    13(2673915-2675387)
    lizard
    (Anolis carolinensis)
    Reptilia TLX36
    T-cell leukemia homeobox 3
    88(a)
    1 ↔ 1
    1(130190167-130210433)
    African clawed frog
    (Xenopus laevis)
    Amphibia tlx3-A-prov2 homeobox protein 11-like 2 75.73(n)    AF283693.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tlx3b2 T-cell leukemia, homeobox 3b 78.89(n)   266965  AF398519.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta C153 mesoderm cell fate specification RNA
    polymerase more
    67(a)   93E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea cog-16
    Protein COG-1, isoform a
    23(a)
    many ↔ many
    II(14902493-14907533) WBGene00000584


    ENSEMBL Gene Tree for TLX3 (if available)
    TreeFam Gene Tree for TLX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLX3 gene
    NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  HMX22  
    NKX6-32  NKX3-22  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  
    HMX12  
    2 SIMAP similar genes for TLX3 using alignment to 1 protein entry:     TLX3_HUMAN:
    TLX2    TLX1

    Find genes that share paralogs with TLX3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLX3 (see all 24)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809172401,2
    C--170737858(+) TCCCCC/GCATCT 1 -- int10--------
    rs9710071,2
    F,H--170737961(+) ACAGGC/ACCTGG 1 -- int15Minor allele frequency- A:0.00MN NS EA 602
    rs1430507451,2
    C--170738260(+) GCGCGG/TGCTGG 1 -- int10--------
    rs2005885921,2
    C--170738422(+) GGCGGA/GGCGGC 2 E G mis10--------
    rs1428022071,2
    C--170738454(+) TGCAGC/ATGCAA 2 /M /L mis11Minor allele frequency- A:0.00NA 3328
    rs1498137121,2
    C,F--170738580(+) AGGTTC/TCCGCT 2 P S mis12Minor allele frequency- T:0.00NA EU 5459
    rs2016006771,2
    C--170738586(+) CCGCTC/GTCACC 2 L V mis10--------
    rs1458070291,2
    C,F--170738597(+) TCCCTG/CGTGTG 2 /L syn11Minor allele frequency- C:0.00NA 4318
    rs9184721,2
    C,A--170738836(+) GGCCCA/GGGCCT 1 -- ut31 ese35Minor allele frequency- G:0.32NA 128
    rs608501321,2
    C,F--170739090(+) TTTCCG/TTTCCT 1 -- ut312Minor allele frequency- T:0.12WA 120

    HapMap Linkage Disequilibrium report for TLX3 (170736288 - 170739138 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TLX3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLX3
    DNA2.0 Custom Variant and Variant Library Synthesis for TLX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604640    OMIM disorders: --

    4 diseases for TLX3:    
    About MalaCards
    t-cell leukemia    congenital central hypoventilation syndrome    central hypoventilation syndrome    precursor t-cell acute lymphoblastic leukemia

    1 disease from the University of Copenhagen DISEASES database for TLX3:
    Leukemia

    Find genes that share disorders with TLX3           About GenesLikeMe

    1 Novoseek inferred disease relationship for TLX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 86.5 16 18835836 (3), 18368072 (3), 12970786 (2), 15334547 (1) (see all 6)

    Genetic Association Database (GAD): TLX3
    Human Genome Epidemiology (HuGE) Navigator: TLX3 (4 documents)

    Export disorders for TLX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLX3 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with TLX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34--&gt;q35 by radiation hybrid mapping. (PubMed id 11435718)1, 3, 9 Lee-Kirsch M.A....Gahr M. (Cytogenet. Cell Genet. 2001)
    2. Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (PubMed id 15240857)1, 4 Weese-Mayer D.E....Marazita M.L. (Pediatr. Res. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization. (PubMed id 11435716)1, 3 Cinti R....Ceccherini I. (Cytogenet. Cell Genet. 2001)
    5. Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. (PubMed id 18368072)1, 9 Baak U....Burmeister T. (Leukemia 2008)
    6. Mutational analysis of the RNX gene in congenital central hypoventilation syndrome. (PubMed id 12407709)1, 9 Matera I....Ceccherini I. (Am. J. Med. Genet. 2002)
    7. t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe FranAsais de CytogAcnActique HAcmatologique (GFCH). (PubMed id 12970786)1, 9 Berger R....Bernard O.A. (Leukemia 2003)
    8. A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. (PubMed id 11587205)1, 9 Bernard O.A....Berger R. (Leukemia 2001)
    9. Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. (PubMed id 15334547)1, 9 Su X.Y....Bernard O.A. (amp 2004)
    10. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. (PubMed id 22366949)1 Della Gatta G....Ferrando A.A. (Nat. Med. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30012 HGNC: 13532 AceView: TLX3 Ensembl:ENSG00000164438 euGenes: HUgn30012
    ECgene: TLX3 Kegg: 30012 H-InvDB: TLX3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLX3 gene:
    Search GeneIP for patents involving TLX3

    GeneCards and IP:
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