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Aliases for TLX3 Gene

Aliases for TLX3 Gene

  • T-Cell Leukemia Homeobox 3 2 3
  • HOX11L2 3 4 6
  • T-Cell Leukemia, Homeobox 3 2 3
  • Homeobox Protein Hox-11L2 3 4
  • Homeo Box 11-Like 2 2 3
  • RNX 3 6
  • T-Cell Leukemia Homeobox Protein 3 3

External Ids for TLX3 Gene

Previous HGNC Symbols for TLX3 Gene

  • HOX11L2

Previous GeneCards Identifiers for TLX3 Gene

  • GC05P170971
  • GC05P171438
  • GC05P170671
  • GC05P170717
  • GC05P170668
  • GC05P170736
  • GC05P165834

Summaries for TLX3 Gene

Entrez Gene Summary for TLX3 Gene

  • RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TLX3 Gene

TLX3 (T-Cell Leukemia Homeobox 3) is a Protein Coding gene. Diseases associated with TLX3 include precursor t-cell acute lymphoblastic leukemia and t-cell leukemia. Among its related pathways are Transcriptional misregulation in cancer and SIDS Susceptibility Pathways. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NKX2-5.

Gene Wiki entry for TLX3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX3 Gene

Genomics for TLX3 Gene

Regulatory Elements for TLX3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TLX3 Gene

171,309,284 bp from pter
171,312,134 bp from pter
2,851 bases
Plus strand

Genomic View for TLX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX3 Gene

Proteins for TLX3 Gene

  • Protein details for TLX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell leukemia homeobox protein 3
    Protein Accession:
    Secondary Accessions:
    • Q96AD3

    Protein attributes for TLX3 Gene

    291 amino acids
    Molecular mass:
    31867 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLX3 Gene

Proteomics data for TLX3 Gene at MOPED

Post-translational modifications for TLX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TLX3 Gene

Domains for TLX3 Gene

Gene Families for TLX3 Gene

Protein Domains for TLX3 Gene

Suggested Antigen Peptide Sequences for TLX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with TLX3: view

Function for TLX3 Gene

Gene Ontology (GO) - Molecular Function for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 22516263
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TLX3: view
genes like me logo Genes that share phenotypes with TLX3: view

Animal Models for TLX3 Gene

MGI Knock Outs for TLX3:

Animal Model Products

miRNA for TLX3 Gene

miRTarBase miRNAs that target TLX3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TLX3 Gene

Localization for TLX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLX3 Gene

Subcellular locations from

Jensen Localization Image for TLX3 Gene COMPARTMENTS Subcellular localization image for TLX3 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TLX3: view

Pathways for TLX3 Gene

genes like me logo Genes that share pathways with TLX3: view

Pathways by source for TLX3 Gene

1 BioSystems pathway for TLX3 Gene
1 KEGG pathway for TLX3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TLX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001708 cell fate specification --
GO:0001764 neuron migration IEA --
GO:0002087 regulation of respiratory gaseous exchange by neurological system process IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007417 central nervous system development IEA --
genes like me logo Genes that share ontologies with TLX3: view

Transcripts for TLX3 Gene

mRNA/cDNA for TLX3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLX3 Gene

T-cell leukemia homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLX3 Gene

No ASD Table

Relevant External Links for TLX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLX3 Gene

mRNA expression in normal human tissues for TLX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLX3 Gene

This gene is overexpressed in Brain - Cerebellum (25.5) and Brain - Cerebellar Hemisphere (23.4).

SOURCE GeneReport for Unigene cluster for TLX3 Gene Hs.249125

genes like me logo Genes that share expressions with TLX3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TLX3 Gene

Orthologs for TLX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TLX3 35
  • 95.42 (n)
  • 98.97 (a)
TLX3 36
  • 99 (a)
(Canis familiaris)
Mammalia TLX3 35
  • 96.11 (n)
  • 99.66 (a)
TLX3 36
  • 100 (a)
(Mus musculus)
Mammalia Tlx3 35
  • 95.19 (n)
  • 99.66 (a)
Tlx3 16
Tlx3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tlx3 35
  • 95.53 (n)
  • 99.66 (a)
(Monodelphis domestica)
Mammalia TLX3 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia TLX3 36
  • 98 (a)
(Pan troglodytes)
Mammalia TLX3 36
  • 100 (a)
(Gallus gallus)
Aves TLX3 36
  • 97 (a)
(Anolis carolinensis)
Reptilia TLX3 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tlx3 35
  • 74.13 (n)
  • 84.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia tlx3-A-prov 35
(Danio rerio)
Actinopterygii tlx3b 35
  • 68.36 (n)
  • 74.28 (a)
CABZ01067175.1 36
  • 68 (a)
tlx3b 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta C15 37
  • 67 (a)
C15 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea cog-1 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for TLX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLX3 Gene

Gene Tree for TLX3 (if available)
Gene Tree for TLX3 (if available)

Paralogs for TLX3 Gene

(2) SIMAP similar genes for TLX3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TLX3: view

Variants for TLX3 Gene

Sequence variations from dbSNP and Humsavar for TLX3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs918472 -- 171,311,832(+) GGCCC(A/G)GGCCT utr-variant-3-prime
rs966056 -- 171,310,655(+) CCTCC(A/C)ACTCT intron-variant
rs971007 -- 171,310,957(+) ACAGG(A/C)CCTGG intron-variant
rs1366433 -- 171,308,329(+) TTGCT(C/T)TAGGA upstream-variant-2KB
rs1366434 -- 171,310,656(+) CTCCA(A/C)CTCTC intron-variant

Relevant External Links for TLX3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLX3 Gene

Disorders for TLX3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TLX3 Gene in MalaCards »

(2) Diseases for TLX3 Gene

(1) University of Copenhagen DISEASES for TLX3 Gene

(1) Novoseek inferred disease relationships for TLX3 Gene

Disease -log(P) Hits PubMed IDs
t-all 86.5 11

Relevant External Links for TLX3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TLX3: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for TLX3 Gene

Publications for TLX3 Gene

  1. Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping. (PMID: 11435718) Lee-Kirsch M.A. … Gahr M. (Cytogenet. Cell Genet. 2001) 2 3 23
  2. A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. (PMID: 11587205) Bernard O.A. … Berger R. (Leukemia 2001) 3 23
  3. Mutational analysis of the RNX gene in congenital central hypoventilation syndrome. (PMID: 12407709) Matera I. … Ceccherini I. (Am. J. Med. Genet. 2002) 3 23
  4. t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe FranAsais de CytogAcnActique HAcmatologique (GFCH). (PMID: 12970786) Berger R. … Bernard O.A. (Leukemia 2003) 3 23
  5. Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. (PMID: 15334547) Su X.Y. … Bernard O.A. (Genes Chromosomes Cancer 2004) 3 23

Products for TLX3 Gene

Sources for TLX3 Gene

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