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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLX3 Gene

protein-coding   GIFtS: 54
GCID: GC05P170736

T-Cell Leukemia Homeobox 3

(Previous names: homeo box 11-like 2, T-cell leukemia, homeobox 3)
(Previous symbol: HOX11L2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Cell Leukemia Homeobox 31 2     Homeobox Protein Hox-11L22 3
HOX11L21 2 3 5     RNX2 5
Homeo Box 11-Like 21 2     T-Cell Leukemia Homeobox Protein 32
T-Cell Leukemia, Homeobox 31 2     

External Ids:    HGNC: 135321   Entrez Gene: 300122   Ensembl: ENSG000001644387   OMIM: 6046405   UniProtKB: O437113   

Export aliases for TLX3 gene to outside databases

Previous GC identifers: GC05P170971 GC05P171438 GC05P170671 GC05P170717 GC05P170668 GC05P165834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLX3 Gene:
RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription
factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly
conserved homeodomain (Dear et al., 1993 (PubMed 8099440)).(supplied by OMIM, Mar 2008)

GeneCards Summary for TLX3 Gene: 
TLX3 (T-cell leukemia homeobox 3) is a protein-coding gene. Diseases associated with TLX3 include congenital central hypoventilation syndrome, and central hypoventilation syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

Gene Wiki entry for TLX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLX3 gene promoter:
         AP-2beta   Nkx2-5   AP-2alpha   AP-2gamma   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLX3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

TLX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLX3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P170736:  view genomic region     (about GC identifiers)

Start:
170,736,288 bp from pter      End:
170,739,138 bp from pter
Size:
2,851 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLX3_HUMAN, O43711 (See protein sequence)
Recommended Name: T-cell leukemia homeobox protein 3  
Size: 291 amino acids; 31867 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q96AD3

Explore the universe of human proteins at neXtProt for TLX3: NX_O43711

Explore proteomics data for TLX3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43711

  • TLX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLX3 Protein Expression
    REFSEQ proteins: NP_066305.2  
    ENSEMBL proteins: 
     ENSP00000296921  

    Human Recombinant Protein Products for TLX3: 
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    OriGene Protein Over-expression Lysate for TLX3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TLX3
    GenScript Custom Purified and Recombinant Proteins Services for TLX3
    Novus Biologicals TLX3 Proteins
    Novus Biologicals TLX3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLX3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TLX3 for ontologies           About GeneDecksing



    TLX3 Antibody Products: 
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    Assay Products for TLX3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TLX3 
    Cloud-Clone Corp. CLIAs for TLX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O43711

    ProtoNet protein and cluster: O43711

    UniProtKB/Swiss-Prot: TLX3_HUMAN, O43711
    Similarity: Contains 1 homeobox DNA-binding domain


    TLX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
         
    TLX3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TLX3:
     Decreased viability  Decreased viability of wild-ty 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tlx3):
     behavior/neurological  digestive/alimentary  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  respiratory system  tumorigenesis 

    TLX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tlx3tm1Sjk for TLX3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLX3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLX3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate TLX3 (see all 14):
    hsa-miR-4271 hsa-miR-520d-5p hsa-miR-191 hsa-miR-548k hsa-miR-3133 hsa-miR-548l hsa-miR-1538 hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLX3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TLX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX3

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of TLX3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TLX3 (see all 6)
    OriGene ORF clones in mouse, rat for TLX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLX3 (NM_021025)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX3
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                         Customized lentivirus expression plasmids for stable overexpression of TLX3 

    Cell Line
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    Search LifeMap BioReagents cell lines for TLX3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLX3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TLX3
        SIDS Susceptibility Pathways


    1         Kegg Pathway  (Kegg details for TLX3):
        Transcriptional misregulation in cancer


    TLX3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLX3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/19 Interacting proteins for TLX3 (O437111, 3 ENSP000002969214) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    ING4Q9UNL43, ENSP000003800244I2D: score=1 STRING: ENSP00000380024
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    HNRNPUL1Q9BUJ23, ENSP000003758634I2D: score=1 STRING: ENSP00000375863
    IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001708cell fate specification ----
    GO:0001764neuron migration IEA--
    GO:0002087regulation of respiratory gaseous exchange by neurological system process IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007417central nervous system development IEA--

    TLX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLX3

    Search CenterWatch for drugs/clinical trials and news about TLX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLX3 gene: 
    NM_021025.2  

    Unigene Cluster for TLX3:

    T-cell leukemia homeobox 3
    Hs.249125  [show with all ESTs]
    Unigene Representative Sequence: NM_021025
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000296921(uc003mbf.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLX3
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate TLX3 (see all 14):
    hsa-miR-4271 hsa-miR-520d-5p hsa-miR-191 hsa-miR-548k hsa-miR-3133 hsa-miR-548l hsa-miR-1538 hsa-miR-369-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLX3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TLX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX3
    Clone
    Products:
         
    OriGene clones in human, mouse for TLX3 (see all 6)
    OriGene ORF clones in mouse, rat for TLX3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLX3 (NM_021025)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX3
    Sirion Biotech Customized lentivirus for stable overexpression of TLX3 
                         Customized lentivirus expression plasmids for stable overexpression of TLX3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TLX3
    OriGene qSTAR qPCR primer pairs in human, mouse for TLX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLX3

    Additional mRNA sequence: BC017291.2 

    1 DOTS entry:

    DT.75180880 

    8 AceView cDNA sequences:

    BX283981 BC017291 NM_021025 BG828093 AJ713910 AI202136 AJ714712 R88463 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLX3 expression in normal human tissues (normalized intensities)      TLX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAGCTGC
    TLX3 Expression
    About this image


    TLX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Pons
             Midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             dI3 Interneurons dP3 Neural Domain
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   

    See TLX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLX3

    SOURCE GeneReport for Unigene cluster: Hs.249125
        SABiosciences Expression via Pathway-Focused PCR Arrays including TLX3: 
              Stem Cell Transcription Factors in human mouse rat
              Leukemia in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TLX3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlx31 , 5 T cell leukemia, homeobox 31, 5 95.19(n)1
    99.66(a)1
      11 (19.21 cM)5
    271401  NM_019916.21  NP_064300.21 
     332007525 
    chicken
    (Gallus gallus)
    Aves TLX31 T-cell leukemia homeobox 3 84.16(n)
    86.52(a)
      395867  NM_205014.1  NP_990345.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLX36
    Uncharacterized protein
    87(a)
    1 ↔ 1
    1(130190167-130210433)
    African clawed frog
    (Xenopus laevis)
    Amphibia tlx3-A-prov2 homeobox protein 11-like 2 75.73(n)    AF283693.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tlx3b2 T-cell leukemia, homeobox 3b 78.89(n)   266965  AF398519.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta C151 , 3 mesoderm cell fate specification RNA
    polymerase more3
    C151
    67(a)3
    62.64(n)1
    66.67(a)1
      93E33
    425441  NM_057525.21  NP_476873.21 


    ENSEMBL Gene Tree for TLX3 (if available)
    TreeFam Gene Tree for TLX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLX3 gene
    NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  TLX12  NKX2-32  HMX22  
    NKX6-32  NKX3-22  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  
    HMX12  
    2 SIMAP similar genes for TLX3 using alignment to 1 protein entry:     TLX3_HUMAN:
    TLX2    TLX1

    TLX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/24 SNPs in TLX3 are shown (see all 24)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1809172401,2
    C--170737858(+) TCCCCC/GCATCT 1 -- int10--------
    rs9710071,2
    F,H--170737961(+) ACAGGC/ACCTGG 1 -- int15Minor allele frequency- A:0.00MN NS EA 602
    rs1430507451,2
    C--170738260(+) GCGCGG/TGCTGG 1 -- int10--------
    rs2005885921,2
    C--170738422(+) GGCGGA/GGCGGC 2 E G mis10--------
    rs1428022071,2
    C--170738454(+) TGCAGC/ATGCAA 2 /M /L mis11Minor allele frequency- A:0.00NA 3328
    rs1498137121,2
    C,F--170738580(+) AGGTTC/TCCGCT 2 P S mis12Minor allele frequency- T:0.00NA EU 5459
    rs2016006771,2
    C--170738586(+) CCGCTC/GTCACC 2 L V mis10--------
    rs1458070291,2
    C,F--170738597(+) TCCCTG/CGTGTG 2 /L syn11Minor allele frequency- C:0.00NA 4318
    rs9184721,2
    C,A--170738836(+) GGCCCA/GGGCCT 1 -- ut31 ese35Minor allele frequency- G:0.32NA 128
    rs608501321,2
    C,F--170739090(+) TTTCCG/TTTCCT 1 -- ut312Minor allele frequency- T:0.12WA 120

    HapMap Linkage Disequilibrium report for TLX3 (170736288 - 170739138 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TLX3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TLX3
    DNA2.0 Custom Variant and Variant Library Synthesis for TLX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604640    OMIM disorders: --

    9 diseases for TLX3:    About MalaCards
    congenital central hypoventilation syndrome    central hypoventilation syndrome    t-cell leukemia    acute lymphocytic leukemia
    sudden infant death syndrome    acute lymphoblastic leukemia    leukemia    lymphoblastic leukemia
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TLX3:
    Leukemia

    TLX3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TLX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 86.5 16 18835836 (3), 18368072 (3), 12970786 (2), 15334547 (1) (see all 6)

    Genetic Association Database (GAD): TLX3
    Human Genome Epidemiology (HuGE) Navigator: TLX3 (4 documents)

    Export disorders for TLX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLX3 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with TLX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping. (PubMed id 11435718)1, 3, 9 Lee-Kirsch M.A....Gahr M. (2001)
    2. Sudden infant death syndrome: case-control frequency differences at genes pertinent to early autonomic nervous system embryologic development. (PubMed id 15240857)1, 4 Weese-Mayer D.E....Marazita M.L. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization. (PubMed id 11435716)1, 3 Cinti R....Ceccherini I. (2001)
    5. Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. (PubMed id 18368072)1, 9 Baak U....Burmeister T. (2008)
    6. Mutational analysis of the RNX gene in congenital central hypoventilation syndrome. (PubMed id 12407709)1, 9 Matera I....Ceccherini I. (2002)
    7. t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Francais de Cytogenetique Hematologique (GFCH). (PubMed id 12970786)1, 9 Berger R....Bernard O.A. (2003)
    8. A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. (PubMed id 11587205)1, 9 Bernard O.A....Berger R. (2001)
    9. Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. (PubMed id 15334547)1, 9 Su X.Y....Bernard O.A. (2004)
    10. Reverse engineering of TLX oncogenic transcriptional n etworks identifies RUNX1 as tumor suppressor in T-ALL. (PubMed id 22366949)1 Della Gatta G....Ferrando A.A. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 30012 HGNC: 13532 AceView: TLX3 Ensembl:ENSG00000164438 euGenes: HUgn30012
    ECgene: TLX3 Kegg: 30012 H-InvDB: TLX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLX3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLX3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLX3 gene:
    Search GeneIP for patents involving TLX3

    GeneCards and IP:
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