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TLX2 Gene

protein-coding   GIFtS: 53
GCID: GC02P074740

T-Cell Leukemia Homeobox 2

(Previous names: homeo box 11-like 1, T-cell leukemia, homeobox 2)
(Previous symbol: HOX11L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
T-Cell Leukemia Homeobox 21 2     Neural Crest Homeobox Protein2 3
HOX11L11 2 3 5     NCX2 3
Homeo Box 11-Like 11 2     T-Cell Leukemia, Homeobox 21
Homeobox Protein Hox-11L12 3     T-Cell Leukemia Homeobox Protein 22

External Ids:    HGNC: 50571   Entrez Gene: 31962   Ensembl: ENSG000001152977   OMIM: 6042405   UniProtKB: O437633   
ORGUL members:         

Export aliases for TLX2 gene to outside databases

Previous GC identifers: GC02U990046 GC02P074954 GC02P074698 GC02P074715 GC02P074652 GC02P074596 GC02P074477


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLX2 Gene:
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog
have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans,
loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. (provided by RefSeq, May
2010)

GeneCards Summary for TLX2 Gene:
TLX2 (T-cell leukemia homeobox 2) is a protein-coding gene. Diseases associated with TLX2 include t-cell leukemia, and gastrointestinal stromal tumor. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: TLX2_HUMAN, O43763
Function: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA
via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for
normal development of the enteric nervous system, and for proper development of normal motility of the
gastrointestinal tract (By similarity)

Gene Wiki entry for TLX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLX2 gene promoter:
         E2F-3a   E2F-4   E2F-5   STAT1   E2F-2   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLX2 promoter sequence
   Search Chromatin IP Primers for TLX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

TLX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLX2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074740:  view genomic region     (about GC identifiers)

Start:
74,740,590 bp from pter      End:
74,744,275 bp from pter
Size:
3,686 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLX2_HUMAN, O43763 (See protein sequence)
Recommended Name: T-cell leukemia homeobox protein 2  
Size: 284 amino acids; 30251 Da
1 PDB 3D structure from and Proteopedia for TLX2:
3A03 (3D)    
Secondary accessions: Q9UD56 Q9UQ48

Explore the universe of human proteins at neXtProt for TLX2: NX_O43763

Explore proteomics data for TLX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TLX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057254.1  
    ENSEMBL proteins: 
     ENSP00000233638  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR020479 Homeobox_metazoa
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O43763

    ProtoNet protein and cluster: O43763

    UniProtKB/Swiss-Prot: TLX2_HUMAN, O43763
    Similarity: Contains 1 homeobox DNA-binding domain


    TLX2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLX2_HUMAN, O43763
    Function: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA
    via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for
    normal development of the enteric nervous system, and for proper development of normal motility of the
    gastrointestinal tract (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    TLX2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TLX2:
     Increased HPV18 LCR reporter a 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tlx2):
     craniofacial  digestive/alimentary  embryogenesis  growth/size/body  mortality/aging 
     nervous system 

    TLX2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TLX2: Tlx2tm1Sjk Tlx2tm1Htno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLX2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TLX2 (see all 11):
    hsa-miR-3194-5p hsa-miR-663 hsa-miR-4268 hsa-miR-1908 hsa-miR-500a hsa-miR-1205 hsa-miR-4258 hsa-miR-1233
    SwitchGear 3'UTR luciferase reporter plasmidTLX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLX2

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    GenScript: all cDNA clones in your preferred vector: TLX2 (NM_016170)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLX2_HUMAN, O43763: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    TLX2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLX2 About    
    See pathways by source

    SuperPathContained pathways About
    1Neural Crest Differentiation
    Neural Crest Differentiation
    2ALK2 signaling events
    ALK2 signaling events
    3ALK1 signaling events
    ALK1 signaling events


    3 BioSystems Pathways for TLX2
        Neural Crest Differentiation
    ALK2 signaling events
    ALK1 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TLX2
    Interactions:

        GeneGlobe Interaction Network for TLX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TLX2 (O437633 ENSP000002336384) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    IRF6O148963, ENSP000003559884I2D: score=1 STRING: ENSP00000355988
    IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
    MCM4P339913, ENSP000002621054I2D: score=1 STRING: ENSP00000262105
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0008150biological_process ND--
    GO:0048484enteric nervous system development IEA--

    TLX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TLX2 gene: 
    NM_016170.4  

    Unigene Cluster for TLX2:

    T-cell leukemia homeobox 2
    Hs.168586  [show with all ESTs]
    Unigene Representative Sequence: BC006396
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497238 ENST00000464417 ENST00000233638(uc002sma.2 uc002smb.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat TLX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLX2 (see all 11):
    hsa-miR-3194-5p hsa-miR-663 hsa-miR-4268 hsa-miR-1908 hsa-miR-500a hsa-miR-1205 hsa-miR-4258 hsa-miR-1233
    SwitchGear 3'UTR luciferase reporter plasmidTLX2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLX2
    Clone
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    OriGene ORF clones in mouse, rat for TLX2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLX2 (NM_016170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX2
    Primer
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    OriGene qPCR primer pairs and template standards for TLX2
    OriGene qSTAR qPCR primer pairs in human, mouse for TLX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLX2
      QuantiTect SYBR Green Assays in human, mouse, rat TLX2
      QuantiFast Probe-based Assays in human, mouse, rat TLX2

    Additional mRNA sequence: 

    AB008501.1 AB593086.1 BC006356.2 BC006396.1 BC018611.1 

    4 DOTS entries:

    DT.438504  DT.92051709  DT.99977125  DT.120962822 

    Selected AceView cDNA sequences (see all 28):

    BX283762 BF516561 BC018611 BC006356 NM_016170 AI478961 BC006396 BM722820 
    NM_001534 BG683519 BG329507 BG750951 BG683019 BE260061 AI797648 AW593130 
    AB008501 BX283474 BF314276 BE255933 BF315995 BE255458 AA631074 AA662660 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTAGTGGC
    TLX2 Expression
    About this image


    TLX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Neural Crest (Gastrulation Derivatives)
             Neurospheres
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Placenta (Extraembryonic Tissues)
     
     Eye (Sensory Organs)
    TLX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.168586
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLX2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlx21 , 5 T cell leukemia, homeobox 21, 5 88.15(n)1
    92.96(a)1
      6 (35.94 cM)5
    219091  NM_009392.21  NP_033418.11 
     830683175 
    chicken
    (Gallus gallus)
    Aves TLX21 T-cell leukemia homeobox 2 78.95(n)
    83.55(a)
      101747242  XM_004949853.1  XP_004949910.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tlx26
    T-cell leukemia, homeobox 2
    57(a)
    many ↔ many
    14(5662852-5696532) ENSDARG00000011273
    fruit fly
    (Drosophila melanogaster)
    Insecta C153 mesoderm cell fate specification RNA
    polymerase more
    63(a)   93E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-96
    Protein CEH-9 (ceh-9) mRNA, complete cds
    35(a)
    1 → many
    I(565436-566391) WBGene00000434


    ENSEMBL Gene Tree for TLX2 (if available)
    TreeFam Gene Tree for TLX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLX2 gene
    NKX2-12  NKX6-12  HMX32  NKX3-12  TLX12  NKX2-32  HMX22  NKX6-32  
    NKX3-22  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  HMX12  
    TLX32  
    2 SIMAP similar genes for TLX2 using alignment to 2 protein entries:     TLX2_HUMAN (see all proteins):
    TLX3    TLX1

    TLX2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLX2 (see all 90)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830981281,2
    --74739770(+) TCACCG/TTGTTA 1 -- us2k10--------
    rs1868297151,2
    --74739778(+) TTAGCC/GAGGAT 1 -- us2k10--------
    rs1912141421,2
    --74739814(+) CCACCC/TGCCTC 1 -- us2k10--------
    rs1140097481,2
    C,F--74739920(+) CATTTA/TTGGTT 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs739496761,2
    C,F--74739934(+) CTCCTC/TTAGAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1412005951,2
    --74740001(+) TCTTTA/TTCTTT 1 -- us2k10--------
    rs1432508871,2
    --74740009(+) TTTCTA/GCCCAG 1 -- us2k10--------
    rs101764701,2
    C,F,A,H--74740075(+) CAGGCA/GCCAGG 1 -- us2k112Minor allele frequency- G:0.03NA WA CSA EA 376
    rs788782571,2
    C,F--74740117(+) GGGCAG/TAGTCT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs37554471,2
    C,F,A,H--74740194(+) TACAAG/AGCATT 1 -- us2k127Minor allele frequency- A:0.38NS EA NA WA CSA 2715

    HapMap Linkage Disequilibrium report for TLX2 (74740590 - 74744275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TLX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TLX2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604240    OMIM disorders: --

    7 diseases for TLX2:    
    About MalaCards
    t-cell leukemia    gastrointestinal stromal tumor    megacolon    leukemia
    neuroblastoma    cerebritis    neuronitis


    TLX2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TLX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dysplasia 42.1 1 17505528 (1)


    Export disorders for TLX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLX2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TLX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells. (PubMed id 10446220)1, 2, 9 Iitsuka Y.... Hatano M. (J. Biol. Chem. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1--&gt;p12 and mouse chromosome 6C3-D1. (PubMed id 10343123)1, 3 Puliti A....Ceccherini I. (Cytogenet. Cell Genet. 1999)
    4. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells. (PubMed id 16402914)1, 9 Borghini S....Ceccherini I. (Biochem. J. 2006)
    5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    6. Na+/Ca2+ exchanger is a determinant of excitation-contraction coupling in human embryonic stem cell-derived ventricular cardiomyocytes. (PubMed id 19719399)1 Fu J.D....Li R.A. (Stem Cells Dev. 2010)
    7. Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless. (PubMed id 20389279)2 Miyazono K....Tanokura M. (EMBO J. 2010)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    9. Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway. (PubMed id 20728215)1 Louhivuori L.M....Akerman K.E. (Cell Calcium 2010)
    10. Functional characterization of a minimal sequence essential for the expression of human TLX2 gene. (PubMed id 20044949)1 Borghini S....Ceccherini I. (BMB Rep 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3196 HGNC: 5057 AceView: TLX2 Ensembl:ENSG00000115297 euGenes: HUgn3196
    ECgene: TLX2 H-InvDB: TLX2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLX2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLX2 gene:
    Search GeneIP for patents involving TLX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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