Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLX2 Gene

protein-coding   GIFtS: 53
GCID: GC02P074740

T-cell leukemia homeobox 2

(Previous names: homeo box 11-like 1, T-cell leukemia, homeobox 2 )
(Previous symbol: HOX11L1)
 Explore 7 diseases affiliated with
TLX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TLX2    

Aliases
for TLX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
T-Cell Leukemia Homeobox 21 2     Neural Crest Homeobox Protein2 3
HOX11L11 2 3 5     Enx1
NCX1 2 3     Tlx21
Homeo Box 11-Like 11 2     T-Cell Leukemia, Homeobox 21
Homeobox Protein Hox-11L12 3     T-Cell Leukemia Homeobox Protein 22

External Ids:    HGNC: 50571   Entrez Gene: 31962   Ensembl: ENSG000001152977   OMIM: 6042405   UniProtKB: O437633   

Export aliases for TLX2 gene to outside databases

Previous GC identifers: GC02U990046 GC02P074954 GC02P074698 GC02P074715 GC02P074652 GC02P074596 GC02P074477


Summaries
for TLX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TLX2:
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have
shown that the encoded protein is crucial for the development of the enteric nervous system; in humans,
loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: TLX2_HUMAN, O43763
Function: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via
its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal
development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract
(By similarity)

Gene Wiki entry for TLX2


Genomic Views
for TLX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLX2 gene promoter:
         E2F-3a   E2F-4   E2F-5   STAT1   E2F-2   PPAR-gamma1   E2F-1   E2F   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.1   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

TLX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLX2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074740:  view genomic region     (about GC identifiers)

Start:
 74,740,590 bp from pter      End:
 74,744,769 bp from pter
Size:
 4,180 bases      Orientation:
 plus strand

Proteins
for TLX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLX2_HUMAN, O43763 (See protein sequence)
Recommended Name: T-cell leukemia homeobox protein 2  
Size: 284 amino acids; 30251 Da
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for TLX2:
3A03 (3D)    
Secondary accessions: Q9UD56 Q9UQ48

Explore the universe of human proteins at neXtProt for TLX2: NX_O43763

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43763

    • TLX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057254.1  
    ENSEMBL proteins: 
     ENSP00000448353   ENSP00000233638  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TLX2 
    GenScript Custom Purified and Recombinant Proteins Services for TLX2
    Novus Biologicals TLX2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLX2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    TLX2 for ontologies           About GeneDecksing



    TLX2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TLX2 
    GenScript Custom Superior Antibodies Services for TLX2
    Novus Biologicals TLX2 Antibody
    Search for Antibodies for TLX2 at Abcam  
    Uscn Antibodies for TLX2
    Search ThermoFisher Antibodies for TLX2

    Assay Products for TLX2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLX2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TLX2

    Protein Domains /
    Families
    for TLX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLX2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O43763

    ProtoNet protein and cluster: O43763

    UniProtKB/Swiss-Prot: TLX2_HUMAN, O43763
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for TLX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLX2_HUMAN, O43763
    Function: Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via
    its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal
    development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract
    (By similarity)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLX2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLX2 (see all 11):
    hsa-miR-3194-5p hsa-miR-663 hsa-miR-4268 hsa-miR-1908 hsa-miR-500a hsa-miR-1205 hsa-miR-4258 hsa-miR-1233
    SwitchGear 3'UTR luciferase reporter plasmid: TLX2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLX2 (see all 4)
    OriGene shRNA RFP: TLX2
    OriGene siRNA: TLX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TLX2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLX2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLX2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TLX2 (NM_016170)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TLX2
    Search LifeMap BioReagents cell lines for TLX2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--


    TLX2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TLX2:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-outs for TLX2: Tlx2tm1Sjk Tlx2tm1Htno
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tlx2):
     craniofacial  digestive/alimentary  embryogenesis  growth/size  mortality/aging 
     nervous system 

    TLX2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TLX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neural Crest Differentiation
    		Neural Crest Differentiation1.00
    2ALK1 signaling events
    		ALK1 signaling events1.00
    3Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling
    		ALK2 signaling events0.31


    3 BioSystems Pathways for TLX2 
        Neural Crest Differentiation
    ALK2 signaling events
    ALK1 signaling events


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for TLX2 (O437633 ENSP000002336384) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    IRF6O148963, ENSP000003559884I2D: score=1 STRING: ENSP00000355988
    IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
    MCM4P339913, ENSP000002621054I2D: score=1 STRING: ENSP00000262105
    MEIS1O004703, ENSP000002723694I2D: score=1 STRING: ENSP00000272369
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001707mesoderm formation IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--
    GO:0048484enteric nervous system development IEA--
    GO:0050774negative regulation of dendrite morphogenesis IEA--


    TLX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLX2
    Search CenterWatch for drugs/clinical trials and news about TLX2 

    Transcripts
    for TLX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLX2 gene: 
    NM_016170.4  

    Unigene Cluster for TLX2:

    T-cell leukemia homeobox 2
    Hs.168586  [show with all ESTs]
    Unigene Representative Sequence: BC006396
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497238 ENST00000464417 ENST00000233638(uc002sma.2 uc002smb.2)
    ENST00000460969

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLX2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLX2 (see all 11):
    hsa-miR-3194-5p hsa-miR-663 hsa-miR-4268 hsa-miR-1908 hsa-miR-500a hsa-miR-1205 hsa-miR-4258 hsa-miR-1233
    SwitchGear 3'UTR luciferase reporter plasmid: TLX2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLX2 (see all 4)
    OriGene shRNA RFP: TLX2
    OriGene siRNA: TLX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLX2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLX2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TLX2 (NM_016170)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLX2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLX2

    Additional cDNA sequence: 

    AB008501.1 AB593086.1 BC006356.2 BC006396.1 BC018611.1 

    4 DOTS entries:

    DT.438504  DT.92051709  DT.99977125  DT.120962822 

    24/28 AceView cDNA sequences (see all 28):

    BX283762 NM_001534 NM_016170 BF516561 BC006396 BC006356 BG683519 BM722820 
    AI478961 BC018611 BE260061 AW593130 AI797648 AB008501 BG329507 BG683019 
    BG750951 BF314276 BX283474 BE255933 AA631074 BX393815 AA662660 BF315995 

    GeneLoc Exon Structure


    Expression
    for TLX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTAGTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TLX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Neurospheres (Generation of neuros...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TLX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLX2

    SOURCE GeneReport for Unigene cluster: Hs.168586
        SABiosciences Custom PCR Arrays for TLX2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLX2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLX2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLX2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLX2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX2

    Orthologs
    for TLX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLX2 gene from 2/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii tlx21 T-cell leukemia, homeobox 2 64.09(n)
    67.18(a)    		   170781  NM_153651.2  NP_705937.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta C153 mesoderm cell fate specification RNA
    polymerase more    		 63(a)   93E3   --


    ENSEMBL Gene Tree for TLX2 (if available)
    TreeFam Gene Tree for TLX2 (if available) 

    Paralogs
    for TLX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLX2 gene
    NKX2-12  HMX32  LBX22  NKX3-12  TLX12  NKX2-32  HMX22  NKX3-22  
    NKX2-62  NKX2-82  NKX2-52  LBX12  NKX2-22  NKX2-42  HMX12  TLX32  
    2 SIMAP similar genes for TLX2 using alignment to 3 protein entries:     TLX2_HUMAN (see all proteins):
    TLX3    TLX1

    TLX2 for paralogs           About GeneDecksing



    Genomic Variants
    for TLX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/60 NCBI SNPs in TLX2 are shown (see all 60)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1830981281,2
    		--74739770(+) TCACCG/TTGTTA 1 -- us2k10--------
    rs1868297151,2
    		--74739778(+) TTAGCC/GAGGAT 1 -- us2k10--------
    rs1912141421,2
    		--74739814(+) CCACCC/TGCCTC 1 -- us2k10--------
    rs1140097481,2
    		C,F,--74739920(+) CATTTA/TTGGTT 1 -- us2k11Minor allele frequency- T:0.09WA 118
    rs739496761,2
    		C,--74739934(+) CTCCTC/TTAGAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1412005951,2
    		--74740001(+) TCTTTA/TTCTTT 1 -- us2k10--------
    rs1432508871,2
    		--74740009(+) TTTCTA/GCCCAG 1 -- us2k10--------
    rs101764701,2
    		C,F,A,H,--74740075(+) CAGGCA/GCCAGG 1 -- us2k112Minor allele frequency- G:0.03NA WA CSA EA 376
    rs788782571,2
    		C,F,--74740117(+) GGGCAG/TAGTCT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs37554471,2
    		C,F,A,H,--74740194(+) TACAAG/AGCATT 1 -- us2k127Minor allele frequency- A:0.38NS EA NA WA CSA 2715

    HapMap Linkage Disequilibrium report for TLX2 (74740590 - 74744769 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TLX2
         2 CNVs: 50556 3366

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLX2
    DNA2.0 Custom Variant and Variant Library Synthesis for TLX2

    Disorders / Diseases
    for TLX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLX2 for disorders           About GeneDecksing

    OMIM gene information: 604240    OMIM disorders: --

    7 diseases for TLX2:    About MalaCards
    gastrointestinal stromal tumor    t-cell leukemia    intestinal pseudo-obstruction    leukemia
    megacolon    neuroblastoma    neuronitis

    1 Novoseek disease relationship for TLX2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dysplasia 42.1 1 17505528 (1)


    Export disorders for TLX2 gene to outside databases

    Publications
    for TLX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLX2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with TLX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells. (PubMed id 10446220)1, 2, 9 Iitsuka Y.... Hatano M. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1. (PubMed id 10343123)1, 3 Puliti A....Ceccherini I. (1999)
    4. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells. (PubMed id 16402914)1, 9 Borghini S....Ceccherini I. (2006)
    5. Na+/Ca2+ exchanger is a determinant of excitation-con traction coupling in human embryonic stem cell-derived ventricular cardiomyocyt es. (PubMed id 19719399)1 Fu J.D....Li R.A. (2010)
    6. Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless. (PubMed id 20389279)2 Miyazono K....Tanokura M. (2010)
    7. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    8. Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway. (PubMed id 20728215)1 Louhivuori L.M....Akerman K.E. (2010)
    9. Functional characterization of a minimal sequence ess ential for the expression of human TLX2 gene. (PubMed id 20044949)1 Borghini S....Ceccherini I. (2009)
    10. Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors. (PubMed id 16969514)1 Kaifi J.T....Izbicki J.R. (2006)

    External Searches for TLX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TLX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3196 HGNC: 5057 AceView: TLX2 Ensembl:ENSG00000115297 euGenes: HUgn3196
    ECgene: TLX2 H-InvDB: TLX2

    Other Databases showing TLX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TLX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLX2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLX2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TLX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLX2 gene:
    Search GeneIP for patents involving TLX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TLX2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TLX2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLX2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLX2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TLX2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLX2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLX2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TLX2   OriGene Custom Protein Services for TLX2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLX2
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLX2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLX2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLX2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLX2
     GenScript Custom Purified and Recombinant Proteins Services for TLX2 GenScript cDNA clones with any tag delivered in your preferred vector for TLX2
     GenScript Custom Assay Services for TLX2 GenScript Custom Superior Antibodies Services for TLX2
     GenScript Custom overexpressing Cell Line Services for TLX2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TLX2 promoter
     Search Chromatin IP Primers for TLX2
     RT2 qPCR Primer Assay in human, mouse, rat TLX2
     GNC Network for TLX2
     SABiosciences Custom PCR Arrays for TLX2
     Search Tocris compounds for TLX2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TLX2 antibodies
     TLX2 proteins
     Search for Antibodies for TLX2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TLX2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TLX2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TLX2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX2
     SwitchGear 3'UTR luciferase reporter plasmids for TLX2
     SwitchGear Promoter luciferase reporter plasmids for TLX2
     Search ThermoFisher Antibodies for TLX2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TLX2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4