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Aliases for TLX2 Gene

Aliases for TLX2 Gene

  • T-Cell Leukemia Homeobox 2 2 3 5
  • Neural Crest Homeobox Protein 3 4
  • Homeobox Protein Hox-11L1 3 4
  • Homeo Box 11-Like 1 2 3
  • HOX11L1 3 4
  • NCX 3 4
  • T-Cell Leukemia, Homeobox 2 2

External Ids for TLX2 Gene

Previous HGNC Symbols for TLX2 Gene

  • HOX11L1

Previous GeneCards Identifiers for TLX2 Gene

  • GC02U990046
  • GC02P074954
  • GC02P074698
  • GC02P074715
  • GC02P074652
  • GC02P074596
  • GC02P074740
  • GC02P074477

Summaries for TLX2 Gene

Entrez Gene Summary for TLX2 Gene

  • This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]

GeneCards Summary for TLX2 Gene

TLX2 (T-Cell Leukemia Homeobox 2) is a Protein Coding gene. Diseases associated with TLX2 include t-cell leukemia and neuronal intestinal dysplasia. Among its related pathways are ALK2 signaling events and ALK1 signaling events. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is BARX2.

UniProtKB/Swiss-Prot for TLX2 Gene

  • Transcription activator that binds DNA elements with the consensus sequence 5-CGGTAATTGG-3. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).

Gene Wiki entry for TLX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX2 Gene

Genomics for TLX2 Gene

Regulatory Elements for TLX2 Gene

Promoters for TLX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLX2 Gene

Chromosome:
2
Start:
74,513,463 bp from pter
End:
74,517,148 bp from pter
Size:
3,686 bases
Orientation:
Plus strand

Genomic View for TLX2 Gene

Genes around TLX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX2 Gene

Proteins for TLX2 Gene

  • Protein details for TLX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43763-TLX2_HUMAN
    Recommended name:
    T-cell leukemia homeobox protein 2
    Protein Accession:
    O43763
    Secondary Accessions:
    • Q9UD56
    • Q9UQ48

    Protein attributes for TLX2 Gene

    Size:
    284 amino acids
    Molecular mass:
    30251 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TLX2 Gene

neXtProt entry for TLX2 Gene

Proteomics data for TLX2 Gene at MOPED

Post-translational modifications for TLX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLX2 Gene

Domains & Families for TLX2 Gene

Gene Families for TLX2 Gene

Protein Domains for TLX2 Gene

Suggested Antigen Peptide Sequences for TLX2 Gene

Graphical View of Domain Structure for InterPro Entry

O43763

UniProtKB/Swiss-Prot:

TLX2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with TLX2: view

Function for TLX2 Gene

Molecular function for TLX2 Gene

UniProtKB/Swiss-Prot Function:
Transcription activator that binds DNA elements with the consensus sequence 5-CGGTAATTGG-3. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity).

Gene Ontology (GO) - Molecular Function for TLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TLX2: view
genes like me logo Genes that share phenotypes with TLX2: view

Animal Models for TLX2 Gene

MGI Knock Outs for TLX2:

Animal Model Products

miRNA for TLX2 Gene

miRTarBase miRNAs that target TLX2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLX2 Gene

Localization for TLX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLX2 Gene COMPARTMENTS Subcellular localization image for TLX2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TLX2 Gene

Pathways & Interactions for TLX2 Gene

genes like me logo Genes that share pathways with TLX2: view

Pathways by source for TLX2 Gene

Gene Ontology (GO) - Biological Process for TLX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001707 mesoderm formation IEA --
GO:0050774 negative regulation of dendrite morphogenesis IEA --
genes like me logo Genes that share ontologies with TLX2: view

No data available for SIGNOR curated interactions for TLX2 Gene

Drugs & Compounds for TLX2 Gene

No Compound Related Data Available

Transcripts for TLX2 Gene

Unigene Clusters for TLX2 Gene

T-cell leukemia homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLX2 Gene

No ASD Table

Relevant External Links for TLX2 Gene

GeneLoc Exon Structure for
TLX2
ECgene alternative splicing isoforms for
TLX2

Expression for TLX2 Gene

mRNA expression in normal human tissues for TLX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLX2 Gene

This gene is overexpressed in Testis (x8.3), Colon - Sigmoid (x7.0), Small Intestine - Terminal Ileum (x5.2), and Colon - Transverse (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLX2 Gene



SOURCE GeneReport for Unigene cluster for TLX2 Gene Hs.168586

genes like me logo Genes that share expression patterns with TLX2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TLX2 Gene

Orthologs for TLX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLX2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLX2 36
  • 94 (a)
OneToOne
TLX2 35
  • 90.26 (n)
  • 94.37 (a)
dog
(Canis familiaris)
Mammalia TLX2 35
  • 89.2 (n)
  • 91.2 (a)
TLX2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlx2 16
Tlx2 36
  • 93 (a)
OneToOne
Tlx2 35
  • 88.15 (n)
  • 92.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TLX2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlx2 35
  • 87.68 (n)
  • 91.55 (a)
chicken
(Gallus gallus)
Aves TLX2 35
  • 78.95 (n)
  • 83.55 (a)
zebrafish
(Danio rerio)
Actinopterygii tlx2 36
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta C15 36
  • 38 (a)
OneToMany
C15 37
  • 63 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-9 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for TLX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLX2 Gene

ENSEMBL:
Gene Tree for TLX2 (if available)
TreeFam:
Gene Tree for TLX2 (if available)

Paralogs for TLX2 Gene

(2) SIMAP similar genes for TLX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLX2: view

Variants for TLX2 Gene

Sequence variations from dbSNP and Humsavar for TLX2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2233313 -- 74,515,094(+) GCTGG(G/T)GGGGC reference, synonymous-codon
rs2233314 -- 74,515,654(+) CTCTG(C/G)GACGC reference, missense
rs2233315 -- 74,515,754(+) GAGCG(C/G)CGCTT reference, synonymous-codon
rs3755447 -- 74,513,067(+) TACAA(A/G)GCATT upstream-variant-2KB
rs10176470 -- 74,512,948(+) CAGGC(A/G)CCAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TLX2 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for TLX2 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLX2 Gene

HapMap Linkage Disequilibrium report
TLX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLX2 Gene

Disorders for TLX2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TLX2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
neuronal intestinal dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search TLX2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLX2
genes like me logo Genes that share disorders with TLX2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLX2 Gene

Publications for TLX2 Gene

  1. An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells. (PMID: 10446220) Iitsuka Y. … Hatano M. (J. Biol. Chem. 1999) 3 4 23 67
  2. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells. (PMID: 16402914) Borghini S. … Ceccherini I. (Biochem. J. 2006) 3 23
  3. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1. (PMID: 10343123) Puliti A. … Ceccherini I. (Cytogenet. Cell Genet. 1999) 2 3
  4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for TLX2 Gene

Sources for TLX2 Gene

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