TLX1NB Gene
protein-coding GIFtS: 29
GCID: GC10M102840
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TLX1 neighbor
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Aliases
for TLX1NB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 4
| Aliases |
|---|
| TLX1 Neighbor1 2 | | TLX1 Divergent Gene Protein2 3 | | TDI1 2 3 | | Putative Protein TDI2 | | TD11 2 5 | | Putative TLX1 Neighbor Protein2 | | APT-B71 2 | | |
| External Ids: | HGNC: 371831 | Entrez Gene: 1000382462 | Ensembl: ENSG000002363117 | OMIM: 6127345 | UniProtKB: P0CAT33 |
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Export aliases for TLX1NB gene to outside databasesPrevious GC identifer: GC10M096478
Summaries
for TLX1NB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
fRNAdb sequence ontology for TLX1NB:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
View fRNAdb secondary structures for TLX1NB |
Genomic Views
for TLX1NB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TLX1NB
Other transcription factors
Search SABiosciences Chromatin IP Primers for TLX1NB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLX1NB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24TLX1NB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M102840: view genomic region
(about GC identifiers)
Start:
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102,849,078 bp from pter |
End:
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102,901,023 bp from pter |
Size:
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51,946 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
- n340124
- FR0399740
- n336275
- n378189
102849077 102869990 102890903 chr10
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Proteins
for TLX1NB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TLXNB_HUMAN, P0CAT3 (See
protein sequence)Recommended Name: Putative TLX1 neighbor protein Size: 122 amino acids; 13375 Da
Miscellaneous: Oriented in a head-to-head manner with TLX1/HOX11. Both genes share the same promoter with robustbidirectional activity
Caution: Product of a dubious CDS predictionExplore the universe of human proteins at neXtProt for TLX1NB: NX_P0CAT3
TLX1NB Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001078867.1
Human Recombinant Protein Products:
TLX1NB Antibody Products:
Assay Products for TLX1NB: |
Protein
Domains /
Families
for TLX1NB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P0CAT3 |
Function
for TLX1NB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLX1NB
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLX1NB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TLX1NB (NM_001085398) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLX1NB | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TLX1NB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX1NB |
|
Pathways & Interactions
for TLX1NB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLX1NB
|
Drugs & Compounds
for TLX1NB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TLX1NB
Search CenterWatch for drugs/clinical trials and news about TLX1NB / TLXNB
|
Transcripts
for TLX1NB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
| 1 fRNAdb Secondary structure:
REFSEQ mRNAs for TLX1NB gene: NM_001085398.1 Unigene Cluster for TLX1NB: TLX1 neighbor Hs.662323 [show with all ESTs]Unigene Representative Sequence: BC0196743 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445873(uc001ksv.3) ENST00000425505 ENST00000441069
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLX1NB
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLX1NB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TLX1NB (NM_001085398) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLX1NB | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TLX1NB |
Additional cDNA sequence: BC019674.1 Y11608.1 2 DOTS entries: DT.101975796 DT.40220038
GeneLoc Exon Structure
|
Expression
for TLX1NB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TLX1NB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
SOURCE GeneReport for Unigene cluster: Hs.662323
SABiosciences Custom PCR Arrays for TLX1NB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLX1NB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TLX1NB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLX1NB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLX1NB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX1NB |
Orthologs
for TLX1NB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TLX1NB (if available)
TreeFam Gene Tree for TLX1NB (if available) |
Paralogs
for TLX1NB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TLX1NB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TLX1NB (102849078 - 102901023 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TLX1NB
1 CNV: 4711 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TLX1NB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TLX1NB for disorders About MalaCards
TLX1NB for disorders About GeneDecksing
OMIM gene information: 612734 603188 607499
Export disorders for TLX1NB gene to outside databases
|
Publications
for TLX1NB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TLX1NB gene integrated from 9 sources:
(articles sorted by number of sources associating them with TLX1NB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PubMed id 17303350)1, 2, 3 Greene W.K....Bellgard M.I. (2007)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- (PubMed id 15103394)10
- (PubMed id 18089548)10
- (PubMed id 15608161)10
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External Searches for TLX1NB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TLX1NB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TLX1NB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TLX1NB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TLX1NB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TLX1NB gene:
Search GeneIP for patents involving TLX1NB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TLX1NB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TLX1NB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLX1NB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLX1NB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TLX1NB | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLX1NB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLX1NB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLX1NB | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLX1NB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLX1NB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX1NB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLX1NB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLX1NB |
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 |  |  |  | |
| | | | Search Tocris compounds for TLX1NB |
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 | | | TLX1NB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX1NB |
|  |  |  | | | | ThermoFisher Antibodies for TLX1NB |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TLX1NB |
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