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Aliases for TLX1NB Gene

Subcategory (RNA class) for TLX1NB Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for TLX1NB Gene

  • TLX1 Neighbor 2 3 5
  • TLX1 Divergent Gene Protein 3 4
  • TDI 3 4
  • Putative TLX1 Neighbor Protein 3
  • APT-B7 3
  • TD1 3

External Ids for TLX1NB Gene

Previous GeneCards Identifiers for TLX1NB Gene

  • GC10M102840
  • GC10M096478

Summaries for TLX1NB Gene

GeneCards Summary for TLX1NB Gene

TLX1NB (TLX1 Neighbor) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX1NB Gene

Genomics for TLX1NB Gene

Regulatory Elements for TLX1NB Gene

Enhancers for TLX1NB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F101030 1 FANTOM5 ENCODE 11.6 +108.0 108019 6.4 HDGF ATF1 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 ZNF121 PDZD7 KAZALD1 TLX1 TLX1NB SEMA4G ENSG00000236662 MRPL43 TWNK MIR608 SFXN3
GH10F101161 0.4 ENCODE 11.5 -20.7 -20663 0.2 ELF3 ZNF76 ARID4B ZNF2 RAD21 ZEB1 RFX5 SCRT2 ZNF143 ZNF391 TLX1NB TLX1 RNY5P7
GH10F101183 0.4 ENCODE 11.4 -41.9 -41853 0.2 TLX1NB TLX1 SMARCE1P7 GC10M101227
GH10F101334 1 VISTA 10.5 -194.0 -193977 0.8 RNU2-43P RNU2-59P TLX1NB TLX1 BTRC GC10P101339 ENSG00000230967
GH10F101142 0.5 Ensembl ENCODE 7.5 -1.1 -1113 0.7 CTCF MXI1 SUZ12 SAP130 ARID4B MAX ZNF48 RAD21 RFX5 GLIS2 TLX1NB RNY5P7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TLX1NB on UCSC Golden Path with GeneCards custom track

Genomic Location for TLX1NB Gene

Chromosome:
10
Start:
101,089,321 bp from pter
End:
101,141,266 bp from pter
Size:
51,946 bases
Orientation:
Minus strand

Genomic View for TLX1NB Gene

Genes around TLX1NB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX1NB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX1NB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX1NB Gene

Proteins for TLX1NB Gene

  • Protein details for TLX1NB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CAT3-TLXNB_HUMAN
    Recommended name:
    Putative TLX1 neighbor protein
    Protein Accession:
    P0CAT3

    Protein attributes for TLX1NB Gene

    Size:
    122 amino acids
    Molecular mass:
    13375 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Oriented in a head-to-head manner with TLX1/HOX11. Both genes share the same promoter with robust bidirectional activity.

neXtProt entry for TLX1NB Gene

Post-translational modifications for TLX1NB Gene

No Post-translational modifications

No data available for DME Specific Peptides for TLX1NB Gene

Domains & Families for TLX1NB Gene

Protein Domains for TLX1NB Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TLX1NB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLX1NB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TLX1NB Gene

Function for TLX1NB Gene

Phenotypes for TLX1NB Gene

GenomeRNAi human phenotypes for TLX1NB:
genes like me logo Genes that share phenotypes with TLX1NB: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLX1NB Gene

Localization for TLX1NB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TLX1NB Gene

Pathways & Interactions for TLX1NB Gene

SuperPathways for TLX1NB Gene

No Data Available

Interacting Proteins for TLX1NB Gene

Gene Ontology (GO) - Biological Process for TLX1NB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TLX1NB Gene

Transcripts for TLX1NB Gene

mRNA/cDNA for TLX1NB Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLX1NB Gene

TLX1 neighbor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLX1NB Gene

No ASD Table

Relevant External Links for TLX1NB Gene

GeneLoc Exon Structure for
TLX1NB
ECgene alternative splicing isoforms for
TLX1NB

Expression for TLX1NB Gene

mRNA expression in normal human tissues for TLX1NB Gene

mRNA differential expression in normal tissues according to GTEx for TLX1NB Gene

This gene is overexpressed in Spleen (x32.9), Testis (x13.1), and Minor Salivary Gland (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of TLX1NB Gene:

TLX1NB

SOURCE GeneReport for Unigene cluster for TLX1NB Gene:

Hs.662323
genes like me logo Genes that share expression patterns with TLX1NB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TLX1NB Gene

Orthologs for TLX1NB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TLX1NB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLX1NB 34
  • 98.53 (n)
Species where no ortholog for TLX1NB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TLX1NB Gene

ENSEMBL:
Gene Tree for TLX1NB (if available)
TreeFam:
Gene Tree for TLX1NB (if available)

Paralogs for TLX1NB Gene

No data available for Paralogs for TLX1NB Gene

Variants for TLX1NB Gene

Sequence variations from dbSNP and Humsavar for TLX1NB Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1005525 -- 101,122,584(+) TCAGA(A/G)GAGTT intron-variant
rs1051723 -- 101,137,300(+) ACCCA(C/T)TTCTC intron-variant, utr-variant-3-prime
rs1051724 -- 101,137,454(+) CAGGC(A/T)CAGGT intron-variant, utr-variant-3-prime
rs1051725 -- 101,137,554(+) ACACA(A/G)CAGCC intron-variant, utr-variant-3-prime
rs10579920 -- 101,106,432(+) aaaat(-/AAAAT)GTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLX1NB Gene

Variant ID Type Subtype PubMed ID
esv3624369 CNV gain 21293372
nsv508603 CNV deletion 20534489
nsv831966 CNV gain 17160897

Variation tolerance for TLX1NB Gene

Gene Damage Index Score: 5.67; 72.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLX1NB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLX1NB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLX1NB Gene

Disorders for TLX1NB Gene

Relevant External Links for TLX1NB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLX1NB

No disorders were found for TLX1NB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLX1NB Gene

Publications for TLX1NB Gene

  1. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PMID: 17303350) Greene W.K. … Bellgard M.I. (Gene 2007) 2 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TLX1NB Gene

Sources for TLX1NB Gene

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