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Aliases for TLX1NB Gene

Subcategory (RNA class) for TLX1NB Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for TLX1NB Gene

  • TLX1 Neighbor 2 3 5
  • TLX1 Divergent Gene Protein 3 4
  • TDI 3 4
  • Putative TLX1 Neighbor Protein 3
  • TLX1 Divergent 2
  • APT-B7 3
  • TD1 3

External Ids for TLX1NB Gene

Previous GeneCards Identifiers for TLX1NB Gene

  • GC10M102840
  • GC10M096478

Summaries for TLX1NB Gene

GeneCards Summary for TLX1NB Gene

TLX1NB (TLX1 Neighbor) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for TLX1NB Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX1NB Gene

Genomics for TLX1NB Gene

Regulatory Elements for TLX1NB Gene

Enhancers for TLX1NB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H101142 1.3 Ensembl ENCODE dbSUPER 7.5 -1.1 -1113 0.7 CTCF MXI1 RB1 SAP130 ARID4B MAX RAD21 RFX5 CC2D1A GLIS2 TLX1NB RNY5P7
GH10H101161 0.8 ENCODE 11.5 -20.7 -20663 0.2 ELF3 RB1 ARID4B ZNF76 ZNF2 RAD21 ZEB1 RFX5 SCRT2 ZNF143 TLX1NB TLX1 RNY5P7
GH10H101183 0.2 ENCODE 11.4 -41.9 -41853 0.2 TLX1NB TLX1 SMARCE1P7 GC10M101227
GH10H101334 0.2 VISTA 10.5 -194.0 -193977 0.8 RNU2-43P RNU2-59P TLX1NB TLX1 BTRC GC10P101339 ENSG00000230967
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLX1NB on UCSC Golden Path with GeneCards custom track

Genomic Locations for TLX1NB Gene

Genomic Locations for TLX1NB Gene
51,946 bases
Minus strand

Genomic View for TLX1NB Gene

Genes around TLX1NB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX1NB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX1NB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX1NB Gene

Proteins for TLX1NB Gene

  • Protein details for TLX1NB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative TLX1 neighbor protein
    Protein Accession:

    Protein attributes for TLX1NB Gene

    122 amino acids
    Molecular mass:
    13375 Da
    Quaternary structure:
    No Data Available
    • Oriented in a head-to-head manner with TLX1/HOX11. Both genes share the same promoter with robust bidirectional activity.

neXtProt entry for TLX1NB Gene

Post-translational modifications for TLX1NB Gene

No Post-translational modifications

No data available for DME Specific Peptides for TLX1NB Gene

Domains & Families for TLX1NB Gene

Protein Domains for TLX1NB Gene


Suggested Antigen Peptide Sequences for TLX1NB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLX1NB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TLX1NB Gene

Function for TLX1NB Gene

Phenotypes From GWAS Catalog for TLX1NB Gene

Phenotypes for TLX1NB Gene

GenomeRNAi human phenotypes for TLX1NB:
genes like me logo Genes that share phenotypes with TLX1NB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLX1NB Gene

Localization for TLX1NB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TLX1NB Gene

Pathways & Interactions for TLX1NB Gene

SuperPathways for TLX1NB Gene

No Data Available

Interacting Proteins for TLX1NB Gene

Gene Ontology (GO) - Biological Process for TLX1NB Gene


No data available for Pathways by source and SIGNOR curated interactions for TLX1NB Gene

Drugs & Compounds for TLX1NB Gene

No Compound Related Data Available

Transcripts for TLX1NB Gene

mRNA/cDNA for TLX1NB Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLX1NB Gene

TLX1 neighbor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLX1NB Gene

No ASD Table

Relevant External Links for TLX1NB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLX1NB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLX1NB Gene

mRNA differential expression in normal tissues according to GTEx for TLX1NB Gene

This gene is overexpressed in Spleen (x32.9), Testis (x13.1), and Minor Salivary Gland (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of TLX1NB Gene:


SOURCE GeneReport for Unigene cluster for TLX1NB Gene:

genes like me logo Genes that share expression patterns with TLX1NB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLX1NB Gene

Orthologs for TLX1NB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TLX1NB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLX1NB 33
  • 98.53 (n)
Species where no ortholog for TLX1NB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TLX1NB Gene

Gene Tree for TLX1NB (if available)
Gene Tree for TLX1NB (if available)

Paralogs for TLX1NB Gene

No data available for Paralogs for TLX1NB Gene

Variants for TLX1NB Gene

Sequence variations from dbSNP and Humsavar for TLX1NB Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000102628 -- 101,110,923(+) CTTCC(A/G)GGACA intron-variant
rs1000210372 -- 101,118,817(+) ACAGA(C/T)TTTTG intron-variant
rs1000255214 -- 101,120,866(+) CTCAT(A/G)AACTG intron-variant
rs1000325920 -- 101,123,925(+) TCTGT(A/G)TGGAA intron-variant
rs1000384061 -- 101,138,128(+) GAATA(C/T)TTATA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TLX1NB Gene

Variant ID Type Subtype PubMed ID
nsv831966 CNV gain 17160897
nsv508603 CNV deletion 20534489
esv3624369 CNV gain 21293372

Variation tolerance for TLX1NB Gene

Gene Damage Index Score: 5.67; 72.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLX1NB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLX1NB Gene

Disorders for TLX1NB Gene

Relevant External Links for TLX1NB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TLX1NB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLX1NB Gene

Publications for TLX1NB Gene

  1. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PMID: 17303350) Greene WK … Bellgard MI (Gene 2007) 2 3 4 60
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for TLX1NB Gene

Sources for TLX1NB Gene

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