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Aliases for TLX1NB Gene

Subcategory (RNA class) for TLX1NB Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for TLX1NB Gene

  • TLX1 Neighbor 2 3 5
  • TLX1 Divergent Gene Protein 3 4
  • TDI 3 4
  • Putative TLX1 Neighbor Protein 3
  • TLX1 Divergent 2
  • APT-B7 3
  • TD1 3

External Ids for TLX1NB Gene

Previous GeneCards Identifiers for TLX1NB Gene

  • GC10M102840
  • GC10M096478

Summaries for TLX1NB Gene

GeneCards Summary for TLX1NB Gene

TLX1NB (TLX1 Neighbor) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for TLX1NB Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX1NB Gene

Genomics for TLX1NB Gene

GeneHancer (GH) Regulatory Elements for TLX1NB Gene

Promoters and enhancers for TLX1NB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I101142 Enhancer 1.2 Ensembl ENCODE dbSUPER 557.5 -1.1 -1112 0.7 RB1 ARID4B ZNF48 RAD21 RFX5 ZNF335 GLIS2 ARID2 ZNF207 ZNF143 TLX1NB RNY5P7
GH10I101030 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 +108.0 108019 6.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS PDZD7 SFXN3 MRPL43 TWNK KAZALD1 TLX1 TLX1NB SEMA4G ENSG00000236662 MIR608
GH10I101161 Enhancer 0.8 ENCODE 11.5 -20.7 -20663 0.2 ELF3 RB1 ARID4B ZNF76 SIN3A ZNF2 RAD21 RFX5 ZEB1 SCRT2 TLX1NB TLX1 RNY5P7
GH10I101183 Enhancer 0.2 ENCODE 11.4 -41.9 -41853 0.2 SMARCE1P7 TLX1NB TLX1 LINC01514 GC10M101227
GH10I101334 Enhancer 0.2 VISTA 10.5 -194.0 -193976 0.8 RNU2-43P RNU2-59P TLX1NB TLX1 BTRC GC10P101339 ENSG00000230967
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLX1NB on UCSC Golden Path with GeneCards custom track

Genomic Locations for TLX1NB Gene

Genomic Locations for TLX1NB Gene
chr10:101,089,321-101,141,266
(GRCh38/hg38)
Size:
51,946 bases
Orientation:
Minus strand
chr10:102,849,078-102,890,903
(GRCh37/hg19)

Genomic View for TLX1NB Gene

Genes around TLX1NB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX1NB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX1NB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX1NB Gene

Proteins for TLX1NB Gene

  • Protein details for TLX1NB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CAT3-TLXNB_HUMAN
    Recommended name:
    Putative TLX1 neighbor protein
    Protein Accession:
    P0CAT3

    Protein attributes for TLX1NB Gene

    Size:
    122 amino acids
    Molecular mass:
    13375 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Oriented in a head-to-head manner with TLX1/HOX11. Both genes share the same promoter with robust bidirectional activity.

neXtProt entry for TLX1NB Gene

Post-translational modifications for TLX1NB Gene

No Post-translational modifications

No data available for DME Specific Peptides for TLX1NB Gene

Domains & Families for TLX1NB Gene

Protein Domains for TLX1NB Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TLX1NB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TLX1NB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TLX1NB Gene

Function for TLX1NB Gene

Phenotypes From GWAS Catalog for TLX1NB Gene

Phenotypes for TLX1NB Gene

GenomeRNAi human phenotypes for TLX1NB:
genes like me logo Genes that share phenotypes with TLX1NB: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLX1NB Gene

Localization for TLX1NB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TLX1NB Gene

Pathways & Interactions for TLX1NB Gene

SuperPathways for TLX1NB Gene

No Data Available

Interacting Proteins for TLX1NB Gene

Gene Ontology (GO) - Biological Process for TLX1NB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TLX1NB Gene

Drugs & Compounds for TLX1NB Gene

No Compound Related Data Available

Transcripts for TLX1NB Gene

mRNA/cDNA for TLX1NB Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLX1NB Gene

TLX1 neighbor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLX1NB Gene

No ASD Table

Relevant External Links for TLX1NB Gene

GeneLoc Exon Structure for
TLX1NB
ECgene alternative splicing isoforms for
TLX1NB

Expression for TLX1NB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLX1NB Gene

mRNA differential expression in normal tissues according to GTEx for TLX1NB Gene

This gene is overexpressed in Spleen (x32.9), Testis (x13.1), and Minor Salivary Gland (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of TLX1NB Gene:

TLX1NB

SOURCE GeneReport for Unigene cluster for TLX1NB Gene:

Hs.662323
genes like me logo Genes that share expression patterns with TLX1NB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLX1NB Gene

Orthologs for TLX1NB Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TLX1NB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLX1NB 33
  • 98.53 (n)
Species where no ortholog for TLX1NB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TLX1NB Gene

ENSEMBL:
Gene Tree for TLX1NB (if available)
TreeFam:
Gene Tree for TLX1NB (if available)

Paralogs for TLX1NB Gene

No data available for Paralogs for TLX1NB Gene

Variants for TLX1NB Gene

Sequence variations from dbSNP and Humsavar for TLX1NB Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000102628 -- 101,110,923(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000210372 -- 101,118,817(-) T/C intron_variant
rs1000255214 -- 101,120,866(-) G/A intron_variant
rs1000325920 -- 101,123,925(-) G/A intron_variant
rs1000384061 -- 101,138,128(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLX1NB Gene

Variant ID Type Subtype PubMed ID
esv3624369 CNV gain 21293372
nsv508603 CNV deletion 20534489
nsv831966 CNV gain 17160897

Variation tolerance for TLX1NB Gene

Gene Damage Index Score: 5.67; 72.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLX1NB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLX1NB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLX1NB Gene

Disorders for TLX1NB Gene

Additional Disease Information for TLX1NB

No disorders were found for TLX1NB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLX1NB Gene

Publications for TLX1NB Gene

  1. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PMID: 17303350) Greene WK … Bellgard MI (Gene 2007) 2 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TLX1NB Gene

Sources for TLX1NB Gene

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