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Aliases for TLX1 Gene

Aliases for TLX1 Gene

  • T-Cell Leukemia Homeobox 1 2 3
  • HOX11 3 4 6
  • TCL3 3 4 6
  • Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint) 2 2
  • T-Cell Leukemia/Lymphoma Protein 3 3 4
  • Homeobox Protein Hox-11 3 4
  • Proto-Oncogene TCL-3 3 4
  • Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To Drosophila Notch) 3
  • Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint 2
  • T-Cell Leukemia Homeobox Protein 1 3
  • Homologous To Drosophila Notch) 2
  • T-Cell Leukemia, Homeobox 1 2

External Ids for TLX1 Gene

Previous HGNC Symbols for TLX1 Gene

  • TCL3
  • HOX11

Previous GeneCards Identifiers for TLX1 Gene

  • GC10P101783
  • GC10P102123
  • GC10P103021
  • GC10P102554
  • GC10P102880
  • GC10P096520
  • GC10P102889

Summaries for TLX1 Gene

Entrez Gene Summary for TLX1 Gene

  • This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for TLX1 Gene

TLX1 (T-Cell Leukemia Homeobox 1) is a Protein Coding gene. Diseases associated with TLX1 include precursor t-cell acute lymphoblastic leukemia and t-cell leukemia. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is NKX2-5.

UniProtKB/Swiss-Prot for TLX1 Gene

  • Controls the genesis of the spleen. Binds to the DNA sequence 5-GGCGGTAAGTGG-3

Gene Wiki entry for TLX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX1 Gene

Genomics for TLX1 Gene

Regulatory Elements for TLX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TLX1 Gene

Start:
101,130,505 bp from pter
End:
101,137,789 bp from pter
Size:
7,285 bases
Orientation:
Plus strand

Genomic View for TLX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX1 Gene

Proteins for TLX1 Gene

  • Protein details for TLX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31314-TLX1_HUMAN
    Recommended name:
    T-cell leukemia homeobox protein 1
    Protein Accession:
    P31314
    Secondary Accessions:
    • A1L4G3
    • O75699
    • Q5VXP2
    • Q9HCA0
    • Q9UD59

    Protein attributes for TLX1 Gene

    Size:
    330 amino acids
    Molecular mass:
    34365 Da
    Quaternary structure:
    • Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3.
    Miscellaneous:
    • TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity

    Alternative splice isoforms for TLX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLX1 Gene

Proteomics data for TLX1 Gene at MOPED

Post-translational modifications for TLX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLX1 Gene

No data available for DME Specific Peptides for TLX1 Gene

Domains for TLX1 Gene

Gene Families for TLX1 Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for TLX1 Gene

Suggested Antigen Peptide Sequences for TLX1 Gene

Graphical View of Domain Structure for InterPro Entry

P31314

UniProtKB/Swiss-Prot:

TLX1_HUMAN :
  • P31314
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with TLX1: view

Function for TLX1 Gene

Molecular function for TLX1 Gene

UniProtKB/Swiss-Prot Function: Controls the genesis of the spleen. Binds to the DNA sequence 5-GGCGGTAAGTGG-3

Gene Ontology (GO) - Molecular Function for TLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 19559479
GO:0043565 sequence-specific DNA binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TLX1: view
genes like me logo Genes that share phenotypes with TLX1: view

Animal Models for TLX1 Gene

MGI Knock Outs for TLX1:

Animal Model Products

CRISPR Products

miRNA for TLX1 Gene

miRTarBase miRNAs that target TLX1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TLX1 Gene

Localization for TLX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLX1 Gene COMPARTMENTS Subcellular localization image for TLX1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TLX1: view

Pathways for TLX1 Gene

genes like me logo Genes that share pathways with TLX1: view

Pathways by source for TLX1 Gene

1 KEGG pathway for TLX1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0030182 neuron differentiation IEA --
GO:0045165 cell fate commitment IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with TLX1: view

Compounds for TLX1 Gene

(5) Novoseek inferred chemical compound relationships for TLX1 Gene

Compound -log(P) Hits PubMed IDs
af 10 73.7 1
oligonucleotide 26.6 4
threonine 18.4 3
zinc 0 1
tyrosine 0 3
genes like me logo Genes that share compounds with TLX1: view

Transcripts for TLX1 Gene

mRNA/cDNA for TLX1 Gene

Unigene Clusters for TLX1 Gene

T-cell leukemia homeobox 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLX1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TLX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLX1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4
SP1: - -
SP2: -
SP3: -

Relevant External Links for TLX1 Gene

GeneLoc Exon Structure for
TLX1
ECgene alternative splicing isoforms for
TLX1

Expression for TLX1 Gene

mRNA expression in normal human tissues for TLX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLX1 Gene

This gene is overexpressed in Spleen (42.9) and Minor Salivary Gland (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TLX1 Gene

SOURCE GeneReport for Unigene cluster for TLX1 Gene Hs.89583

genes like me logo Genes that share expressions with TLX1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TLX1 Gene

Orthologs for TLX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLX1 35
  • 98.96 (n)
  • 99.22 (a)
TLX1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLX1 35
  • 91.72 (n)
  • 95.45 (a)
TLX1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLX1 35
  • 91.11 (n)
  • 96.06 (a)
TLX1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlx1 35
  • 89.29 (n)
  • 96.36 (a)
Tlx1 16
Tlx1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLX1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLX1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlx1 35
  • 89.39 (n)
  • 96.67 (a)
chicken
(Gallus gallus)
Aves TLX1 35
  • 77.7 (n)
  • 78.31 (a)
TLX1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLX1 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tlx1-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tlx1 35
  • 70.01 (n)
  • 76.59 (a)
zebrafish
(Danio rerio)
Actinopterygii tlx1 35
  • 67.95 (n)
  • 71.93 (a)
tlx1 36
  • 68 (a)
OneToOne
tlx3a 35
fruit fly
(Drosophila melanogaster)
Insecta C15 36
  • 36 (a)
OneToMany
C15 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea ceh-9 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1269 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for TLX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLX1 Gene

ENSEMBL:
Gene Tree for TLX1 (if available)
TreeFam:
Gene Tree for TLX1 (if available)

Paralogs for TLX1 Gene

Selected SIMAP similar genes for TLX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLX1: view

Variants for TLX1 Gene

Sequence variations from dbSNP and Humsavar for TLX1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs946328 -- 101,133,588(+) GGGCC(C/T)TAATA intron-variant
rs1051723 -- 101,137,300(+) ACCCA(C/T)TTCTC utr-variant-3-prime
rs1051724 -- 101,137,454(+) CAGGC(A/T)CAGGT utr-variant-3-prime
rs1051725 -- 101,137,554(+) ACACA(A/G)CAGCC utr-variant-3-prime
rs1416361 -- 101,135,555(-) CTCCT(C/T)CCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLX1 Gene

Variant ID Type Subtype PubMed ID
nsv508603 CNV Loss 20534489
nsv831966 CNV Gain 17160897
nsv895966 CNV Loss 21882294

Relevant External Links for TLX1 Gene

HapMap Linkage Disequilibrium report
TLX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLX1 Gene

Disorders for TLX1 Gene

UniProtKB/Swiss-Prot

TLX1_HUMAN
  • Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD.

(1) University of Copenhagen DISEASES for TLX1 Gene

(8) Novoseek inferred disease relationships for TLX1 Gene

Disease -log(P) Hits PubMed IDs
t-all 92.4 36
leukemogenesis 74.5 7
leukemia t-cell 71.1 8
leukemia 52.3 19
lymphoblastic leukemia acute childhood 38.2 1
genes like me logo Genes that share disorders with TLX1: view

Publications for TLX1 Gene

  1. Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells. (PMID: 1352396) Lu M. … Ho A.D. (Oncogene 1992) 3 4 23
  2. HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. (PMID: 1681546) Kennedy M.A. … Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  3. The tcl-3 proto-oncogene altered by chromosomal translocation in T- cell leukemia codes for a homeobox protein. (PMID: 1717256) Lu M. … Ho A.D. (EMBO J. 1991) 3 4 23
  4. Multiple negative elements contribute to repression of the HOX11 proto-oncogene. (PMID: 9778044) Brake R.L. … Watt P.M. (Oncogene 1998) 3 4 23
  5. Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line. (PMID: 10393251) Watt P.M. … Kees U.R. (Gene 1999) 3 4 23

Products for TLX1 Gene

Sources for TLX1 Gene

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