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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLX1 Gene

protein-coding   GIFtS: 53
GCID: GC10P102880

T-cell leukemia homeobox 1

(Previous names: homeo box 11 (T-cell lymphoma 3-associated breakpoint),...)
(Previous symbols: TCL3, HOX11)
 Explore 13 diseases affiliated with
TLX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TLX1    

Aliases
for TLX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
T-Cell Leukemia Homeobox 11 2     T-Cell Leukemia/Lymphoma Protein 32 3
HOX111 2 3 5     Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint)1
TCL31 2 3 5     T-Cell Leukemia, Homeobox 11
Homeobox Protein Hox-112 3     Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To Drosophila
Notch)2
Proto-Oncogene TCL-32 3     T-Cell Leukemia Homeobox Protein 12

External Ids:    HGNC: 50561   Entrez Gene: 31952   Ensembl: ENSG000001078077   OMIM: 1867705   UniProtKB: P313143   

Export aliases for TLX1 gene to outside databases

Previous GC identifers: GC10P101783 GC10P102123 GC10P103021 GC10P102554 GC10P096520


Summaries
for TLX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TLX1:
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox
genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also
involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is
associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'

Gene Wiki entry for TLX1


Genomic Views
for TLX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLX1 gene promoter:
         STAT1   POU2F1   Pbx1a   POU2F1a   p300   STAT1beta   Nkx2-5   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.32

TLX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102880:  view genomic region     (about GC identifiers)

Start:
 102,889,257 bp from pter      End:
 102,897,546 bp from pter
Size:
 8,290 bases      Orientation:
 plus strand

Proteins
for TLX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314 (See protein sequence)
Recommended Name: T-cell leukemia homeobox protein 1  
Size: 330 amino acids; 34365 Da
Subunit: Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3
Subcellular location: Nucleus (Probable)
Miscellaneous: TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust
bidirectional activity
Secondary accessions: A1L4G3 O75699 Q5VXP2 Q9HCA0 Q9UD59
Alternative splicing: 2 isoforms:  P31314-1   P31314-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLX1: NX_P31314

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31314

    • TLX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182446.1  NP_005512.1  

    ENSEMBL proteins: 
     ENSP00000359215   ENSP00000434358   ENSP00000434914  

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    OriGene Protein Over-expression Lysate: TLX1
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    Novus Biologicals TLX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TLX1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TLX1

    Protein Domains /
    Families
    for TLX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLX1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017970 Homeobox_CS
     IPR020479 Homeobox_metazoa
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31314

    ProtoNet protein and cluster: P31314

    1 Blocks protein family: IPB000747 'Homeobox' engrailed-type protein

    UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for TLX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
    Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLX1
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TLX1 (see all 28):
    hsa-miR-302d hsa-miR-520e hsa-miR-522 hsa-miR-128 hsa-miR-302e hsa-miR-340 hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: TLX1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLX1 (see all 7)
    OriGene shRNA RFP: TLX1
    OriGene siRNA: TLX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TLX1

    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    TLX1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tlx1tm1Sjk for TLX1
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tlx1):
     cellular  embryogenesis  hematopoietic system  immune system  nervous system 

    TLX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TLX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/11 Interacting proteins for TLX1 (P313141, 3 ENSP000003592154) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004701, 3, ENSP000002723694EBI-2820655,EBI-1210694 I2D: score=1 STRING: ENSP00000272369
    PPP1CBP621403, ENSP000002961224I2D: score=2 STRING: ENSP00000296122
    NFICP086513, ENSP000003968434I2D: score=1 STRING: ENSP00000396843
    PKNOX1P553473, ENSP000002915474I2D: score=1 STRING: ENSP00000291547
    PPP1CCP368733, ENSP000003350844I2D: score=1 STRING: ENSP00000335084
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417central nervous system development IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0030182neuron differentiation IEA--
    GO:0045165cell fate commitment IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--


    TLX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TLX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLX1
    5 Novoseek chemical compound relationships for TLX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    af 10 73.7 1 16383239 (1)
    oligonucleotide 26.6 6 15384172 (1), 7596820 (1), 10869550 (1), 1352396 (1)
    threonine 18.4 3 15897879 (2), 7909304 (1)
    zinc 0 1 9004130 (1)
    tyrosine 0 3 7866997 (3)

    Search CenterWatch for drugs/clinical trials and news about TLX1 

    Transcripts
    for TLX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLX1 gene (2 alternative transcripts): 
    NM_001195517.1  NM_005521.3  

    Unigene Cluster for TLX1:

    T-cell leukemia homeobox 1
    Hs.89583  [show with all ESTs]
    Unigene Representative Sequence: M62626
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370196(uc021pxd.1 uc001ksw.3) ENST00000463716 ENST00000467928
    ENST00000533319 ENST00000525019

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLX1
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TLX1 (see all 28):
    hsa-miR-302d hsa-miR-520e hsa-miR-522 hsa-miR-128 hsa-miR-302e hsa-miR-340 hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: TLX1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLX1 (see all 7)
    OriGene shRNA RFP: TLX1
    OriGene siRNA: TLX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLX1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TLX1 (NM_001195517)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLX1
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLX1

    Additional cDNA sequence: 

    BC130530.1 M62626.1 M75952.1 S38742.1 

    2 DOTS entries:

    DT.108199  DT.121300709 

    16 AceView cDNA sequences:

    BF514683 CB185049 S38742 BX108942 AA007444 BI837519 M75952 AW149660 
    AW149389 AA007490 BF513502 NM_005521 D57678 BV197636 AI346822 AA922708 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TLX1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4
    SP1:              -     -                           
    SP2:              -                                 
    SP3:                    -                           


    ECgene alternative splicing isoforms for TLX1

    Expression
    for TLX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TLX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    BoneMandibular ProcessBone
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TLX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLX1

    SOURCE GeneReport for Unigene cluster: Hs.89583
        SABiosciences Expression via Pathway-Focused PCR Arrays including TLX1: 
              Leukemia in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for TLX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLX1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TLX11 T-cell leukemia homeobox 1 79.05(n)
    81.02(a)    		   395868  NM_205015.1  NP_990346.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TLX16
    		 --
    		 32(a)
    		 1 ↔ 1
    		 GL343239.1(420275-432520)
    African clawed frog
    (Xenopus laevis)    		 Amphibia tlx1-A-prov2 homeobox protein 11 77.94(n)    AF283694.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tlx3a2 T-cell leukemia, homeobox 3a 76.26(n)   170781  AY045753.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta C153 mesoderm cell fate specification RNA
    polymerase more    		 71(a)   93E3   --


    ENSEMBL Gene Tree for TLX1 (if available)
    TreeFam Gene Tree for TLX1 (if available) 

    Paralogs
    for TLX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLX1 gene
    NKX2-12  HMX32  TLX22  LBX22  NKX3-12  NKX2-32  HMX22  NKX3-22  
    NKX2-62  NKX2-82  NKX2-52  LBX12  NKX2-22  NKX2-42  HMX12  TLX32  
    2 SIMAP similar genes for TLX1 using alignment to 2 protein entries:     TLX1_HUMAN (see all proteins):
    TLX2    TLX3

    TLX1 for paralogs           About GeneDecksing



    Genomic Variants
    for TLX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/183 NCBI SNPs in TLX1 are shown (see all 183)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38089481,2
    		C,F,H,--96519741(+) CTGTGT/CTTTAA 2 -- us2k18Minor allele frequency- C:0.02NS EA NA 866
    rs1138668561,2
    		C,--96520306(+) GCCTGA/C/GTGATT 2 -- us2k10--------
    rs115997111,2
    		H--96520715(+) GGCGCC/TTACAC 4 A syn1 ese30--------
    rs27420171,2
    		H--96521777(+) GTGTCC/ATACCC 2 -- int14Minor allele frequency- A:0.00NS EA 412
    rs171137281,2
    		C,F,H,--96521945(+) TGCTCC/TCGTTT 2 -- int112Minor allele frequency- T:0.15NA NS EA WA 910
    rs1166222841,2
    		C,F,--96522028(+) TTCCCT/CGNNNN 2 -- int11Minor allele frequency- C:0.06WA 118
    rs728420701,2
    		--96522138(+) TGCTGA/GCAGAG 2 -- int10--------
    rs24727201,2
    		H--96522143(+) GCAGAG/AATGGG 2 -- int14Minor allele frequency- A:0.00NS EA 402
    rs27420181,2
    		H--96522359(+) GTGGAG/AGCTGG 2 -- int14Minor allele frequency- A:0.00NS EA 408
    rs27420221,2
    		H--96522535(+) ACCCAG/ACCGGG 2 -- int14Minor allele frequency- A:0.00NS EA 416

    HapMap Linkage Disequilibrium report for TLX1 (102889257 - 102897546 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TLX1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLX1
    DNA2.0 Custom Variant and Variant Library Synthesis for TLX1

    Disorders / Diseases
    for TLX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLX1 for disorders           About GeneDecksing

    OMIM gene information: 186770    OMIM disorders: --

    UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
  • Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia
    • (T-ALL). Translocation t(10;14)(q24;q11) with TCRD

    13 diseases for TLX1:    About MalaCards
    leukemia    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia/lymphoma
    t-cell leukemia    central hypoventilation syndrome    human t-cell leukemia virus type 1    congenital central hypoventilation syndrome
    acute biphenotypic leukemia    neuronitis    lymphoblastic lymphoma    acute leukemia
    hematopoiesis

    1 disease from the University of Copenhagen DISEASES database for TLX1:
    Lymphoblastic leukemia

    8 Novoseek disease relationships for TLX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 92.4 50 15384172 (3), 1717256 (2), 12750702 (2), 7478554 (2) (see all 28)
    leukemogenesis 74.5 8 11587205 (1), 8559142 (1), 15384172 (1), 17303350 (1) (see all 7)
    leukemia t-cell 71.1 10 1352396 (2), 7698766 (1), 1717256 (1), 8559142 (1) (see all 7)
    leukemia 52.3 23 14659882 (3), 14975618 (3), 10393251 (2), 9778044 (2) (see all 13)
    lymphoblastic leukemia acute childhood 38.2 1 7478554 (1)
    tumors 0 8 11069299 (3), 7478554 (2), 18082256 (1), 9811890 (1)
    lymphoma 0 4 11069299 (3)
    cancer 0 4 12750702 (2), 14659882 (1), 7719228 (1)


    Export disorders for TLX1 gene to outside databases

    Publications
    for TLX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLX1 gene, integrated from 9 sources (see all 90):
    (articles sorted by number of sources associating them with TLX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. (PubMed id 1676542)1, 2, 3 Hatano M.... Korsmeyer S.J. (1991)
    2. Multiple negative elements contribute to repression of the HOX11 proto-oncogene. (PubMed id 9778044)1, 2, 9 Brake R.L.... Watt P.M. (1998)
    3. Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells. (PubMed id 1352396)1, 2, 9 Lu M.... Ho A.D. (1992)
    4. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PubMed id 17303350)1, 2, 9 Greene W.K....Bellgard M.I. (2007)
    5. Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line. (PubMed id 10393251)1, 2, 9 Watt P.M.... Kees U.R. (1999)
    6. The tcl-3 proto-oncogene altered by chromosomal translocation in T- cell leukemia codes for a homeobox protein. (PubMed id 1717256)1, 2, 9 Lu M.... Ho A.D. (1991)
    7. MEIS proteins as partners of the TLX1/HOX11 oncoprote in. (PubMed id 19559479)1, 2, 9 Milech N....Watt P.M. (2010)
    8. HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. (PubMed id 1681546)1, 2, 9 Kennedy M.A.... Rabbitts T.H. (1991)
    9. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    10. HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. (PubMed id 9009195)1, 9 Kawabe T....Korsmeyer S.J. (1997)

    External Searches for TLX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TLX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3195 HGNC: 5056 AceView: TLX1 Ensembl:ENSG00000107807 euGenes: HUgn3195
    ECgene: TLX1 H-InvDB: TLX1

    Other Databases showing TLX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TLX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLX1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TLX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLX1 gene:
    Search GeneIP for patents involving TLX1

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