Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TLX1 Gene

protein-coding   GIFtS: 55
GCID: GC10P102889

T-Cell Leukemia Homeobox 1

(Previous names: homeo box 11 (T-cell lymphoma 3-associated breakpoint),...)
(Previous symbols: TCL3, HOX11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
T-Cell Leukemia Homeobox 11 2     Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint)1
HOX111 2 3 5     Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint1
TCL31 2 3 5     Homologous To Drosophila Notch)1
Homeobox Protein Hox-112 3     T-Cell Leukemia, Homeobox 11
Proto-Oncogene TCL-32 3     Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To
Drosophila Notch)2
T-Cell Leukemia/Lymphoma Protein 32 3     T-Cell Leukemia Homeobox Protein 12

External Ids:    HGNC: 50561   Entrez Gene: 31952   Ensembl: ENSG000001078077   OMIM: 1867705   UniProtKB: P313143   

Export aliases for TLX1 gene to outside databases

Previous GC identifers: GC10P101783 GC10P102123 GC10P103021 GC10P102554 GC10P102880 GC10P096520


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TLX1 Gene:
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of
homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This
protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to
chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing
results in multiple transcript variants. (provided by RefSeq, Sep 2010)

GeneCards Summary for TLX1 Gene:
TLX1 (T-cell leukemia homeobox 1) is a protein-coding gene. Diseases associated with TLX1 include precursor t-cell acute lymphoblastic leukemia, and acute biphenotypic leukemia. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NKX2-1.

UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'

Gene Wiki entry for TLX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLX1 gene promoter:
         STAT1   POU2F1   Pbx1a   POU2F1a   p300   STAT1beta   Nkx2-5   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLX1 promoter sequence
   Search Chromatin IP Primers for TLX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.32

TLX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLX1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102889:  view genomic region     (about GC identifiers)

Start:
102,889,257 bp from pter      End:
102,897,546 bp from pter
Size:
8,290 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314 (See protein sequence)
Recommended Name: T-cell leukemia homeobox protein 1  
Size: 330 amino acids; 34365 Da
Subunit: Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3
Miscellaneous: TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust
bidirectional activity
Secondary accessions: A1L4G3 O75699 Q5VXP2 Q9HCA0 Q9UD59
Alternative splicing: 2 isoforms:  P31314-1   P31314-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLX1: NX_P31314

Explore proteomics data for TLX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TLX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182446.1  NP_005512.1  

    ENSEMBL proteins: 
     ENSP00000359215   ENSP00000434358   ENSP00000434914  

    TLX1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TLX1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TLX1
    GenScript Custom Purified and Recombinant Proteins Services for TLX1
    Novus Biologicals TLX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLX1

    TLX1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TLX1
    OriGene Custom Antibody Services for TLX1
    Novus Biologicals TLX1 Antibody
    Abcam antibodies for TLX1
    Cloud-Clone Corp. Antibodies for TLX1
    ThermoFisher Antibodies for TLX1
    LSBio Antibodies in human, mouse, rat for TLX1

    TLX1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TLX1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLX1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLX1
    Cloud-Clone Corp. CLIAs for TLX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    4 InterPro protein domains:
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR020479 Homeobox_metazoa
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31314

    ProtoNet protein and cluster: P31314

    1 Blocks protein domain: IPB000747 'Homeobox' engrailed-type protein

    UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
    Similarity: Contains 1 homeobox DNA-binding domain


    TLX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLX1_HUMAN, P31314
    Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI19559479
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    TLX1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tlx1):
     cellular  embryogenesis  hematopoietic system  immune system  nervous system 

    TLX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tlx1tm1Sjk for TLX1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLX1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLX1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TLX1:
    hsa-mir-340-5p (MIRT019615), hsa-mir-26b-5p (MIRT029889)

    Block miRNA regulation of human, mouse, rat TLX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLX1 (see all 28):
    hsa-miR-302d hsa-miR-520e hsa-miR-522 hsa-miR-128 hsa-miR-302e hsa-miR-340 hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTLX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TLX1
    Predesigned siRNA for gene silencing in human, mouse, rat TLX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TLX1

    Clone
    Products:
         
    OriGene clones in human, mouse for TLX1 (see all 9)
    OriGene ORF clones in mouse, rat for TLX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TLX1 (NM_001195517)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TLX1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TLX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TLX1_HUMAN, P31314: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    TLX1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TLX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TLX1):
        Transcriptional misregulation in cancer


    TLX1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLX1: 
              Leukemia in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for TLX1 (P313141, 3 ENSP000003592154) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004701, 3, ENSP000002723694EBI-2820655,EBI-1210694 I2D: score=1 STRING: ENSP00000272369
    PPP1CBP621403, ENSP000002961224I2D: score=2 STRING: ENSP00000296122
    NFICP086513, ENSP000003968434I2D: score=1 STRING: ENSP00000396843
    PKNOX1P553473, ENSP000002915474I2D: score=1 STRING: ENSP00000291547
    PPP1CCP368733, ENSP000003350844I2D: score=1 STRING: ENSP00000335084
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007417central nervous system development IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0030182neuron differentiation IEA--
    GO:0045165cell fate commitment IEA--

    TLX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLX1

    5 Novoseek inferred chemical compound relationships for TLX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    af 10 73.7 1 16383239 (1)
    oligonucleotide 26.6 6 15384172 (1), 7596820 (1), 10869550 (1), 1352396 (1)
    threonine 18.4 3 15897879 (2), 7909304 (1)
    zinc 0 1 9004130 (1)
    tyrosine 0 3 7866997 (3)



    TLX1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TLX1 gene (2 alternative transcripts): 
    NM_001195517.1  NM_005521.3  

    Unigene Cluster for TLX1:

    T-cell leukemia homeobox 1
    Hs.89583  [show with all ESTs]
    Unigene Representative Sequence: M62626
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370196(uc021pxd.1 uc001ksw.3) ENST00000463716 ENST00000467928
    ENST00000533319 ENST00000525019
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TLX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLX1 (see all 28):
    hsa-miR-302d hsa-miR-520e hsa-miR-522 hsa-miR-128 hsa-miR-302e hsa-miR-340 hsa-miR-519a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTLX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TLX1
    Predesigned siRNA for gene silencing in human, mouse, rat TLX1
    Clone
    Products:
         
    OriGene clones in human, mouse for TLX1 (see all 9)
    OriGene ORF clones in mouse, rat for TLX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TLX1 (NM_001195517)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TLX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLX1
      QuantiTect SYBR Green Assays in human, mouse, rat TLX1
      QuantiFast Probe-based Assays in human, mouse, rat TLX1

    Additional mRNA sequence: 

    BC130530.1 M62626.1 M75952.1 S38742.1 

    2 DOTS entries:

    DT.108199  DT.121300709 

    16 AceView cDNA sequences:

    BF514683 AA007444 M75952 AW149389 BX108942 S38742 CB185049 BI837519 
    AW149660 D57678 BF513502 AA007490 NM_005521 BV197636 AA922708 AI346822 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TLX1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4
    SP1:              -     -                           
    SP2:              -                                 
    SP3:                    -                           


    ECgene alternative splicing isoforms for TLX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TLX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TLX1 Expression
    About this image


    TLX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 6 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Head Mesenchyme (Muscoskeletal System)
             Branchial Arch 2
    TLX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89583
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLX1: 
              Leukemia in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TLX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLX1
    QuantiTect SYBR Green Assays in human, mouse, rat TLX1
    QuantiFast Probe-based Assays in human, mouse, rat TLX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TLX1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlx11 , 5 T cell leukemia, homeobox 11, 5 89.29(n)1
    96.36(a)1
      19 (38.45 cM)5
    219081  NM_021901.31  NP_068701.11 
     451498335 
    chicken
    (Gallus gallus)
    Aves TLX11 T-cell leukemia homeobox 1 77.7(n)
    78.31(a)
      395868  NM_205015.1  NP_990346.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLX16
    T-cell leukemia homeobox 1
    77(a)
    1 ↔ 1
    GL343239.1(419831-452544)
    African clawed frog
    (Xenopus laevis)
    Amphibia tlx1-A-prov2 homeobox protein 11 77.94(n)    AF283694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tlx3a2 T-cell leukemia, homeobox 3a 76.26(n)   170781  AY045753.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta C153 mesoderm cell fate specification RNA
    polymerase more
    71(a)   93E3   --
    worm
    (Caenorhabditis elegans)
    Secernentea ceh-96
    Protein CEH-9 (ceh-9) mRNA, complete cds
    35(a)
    1 → many
    I(565436-566391) WBGene00000434


    ENSEMBL Gene Tree for TLX1 (if available)
    TreeFam Gene Tree for TLX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TLX1 gene
    NKX2-12  NKX6-12  HMX32  TLX22  NKX3-12  NKX2-32  HMX22  NKX6-32  
    NKX3-22  NKX6-22  NKX2-62  NKX2-82  NKX2-52  NKX2-22  NKX2-42  HMX12  
    TLX32  
    2 SIMAP similar genes for TLX1 using alignment to 2 protein entries:     TLX1_HUMAN (see all proteins):
    TLX3    TLX2

    TLX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TLX1 (see all 214)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs287354781,2
    C--96527039(+) AGAGTC/TGTGTG 2 -- ds50012Minor allele frequency- T:0.25WA NA 4
    rs114987751,2
    H--102894942(+) CCCTCT/CGGCAC 2 -- int14Minor allele frequency- C:0.00NS EA 408
    rs93254991,2
    C,A,H--102897801(+) AGAGTC/Tgtgtg 2 -- ds50010--------
    rs3686403821,2
    C--102897801(+) GAGTC-/CG/GT 
            
    gtgtg
    2 -- ds50011CSA 2
    rs556944961,2
    C--102897807(+) GTGTG-/TGTGTG
    TGTGTGTG
    GTGTG
    2 -- ds50010--------
    rs1890276741,2
    C--103250273(+) TTCACC/TGTGTT 2 -- us2k10--------
    rs1929617421,2
    --103250307(+) GACCTC/TGTGAT 2 -- us2k10--------
    rs27887261,2
    C,F,A--103250323(-) AGGCCG/AAGGCG 2 -- us2k19Minor allele frequency- A:0.19NA WA CSA 16
    rs1160521981,2
    F--103250601(+) TAAAAT/CAGGGA 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1852233801,2
    --103250614(+) ATACTC/TATCTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLX1 (102889257 - 102897546 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TLX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895966CNV Loss21882294
    nsv508603CNV Loss20534489
    nsv831966CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLX1
    DNA2.0 Custom Variant and Variant Library Synthesis for TLX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 186770    OMIM disorders: --

    UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
  • Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic
    leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD

  • 15 diseases for TLX1:    
    About MalaCards
    precursor t-cell acute lymphoblastic leukemia    acute biphenotypic leukemia    t-cell leukemia    lymphoblastic leukemia
    congenital central hypoventilation syndrome    lymphoblastic lymphoma    central hypoventilation syndrome    leukemia
    split foot    split hand    human t-cell leukemia virus type 1    acute leukemia
    neuronitis    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for TLX1:
    Lymphoblastic leukemia

    TLX1 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for TLX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 92.4 50 15384172 (3), 1717256 (2), 12750702 (2), 7478554 (2) (see all 28)
    leukemogenesis 74.5 8 11587205 (1), 8559142 (1), 15384172 (1), 17303350 (1) (see all 7)
    leukemia t-cell 71.1 10 1352396 (2), 7698766 (1), 1717256 (1), 8559142 (1) (see all 7)
    leukemia 52.3 23 14659882 (3), 14975618 (3), 10393251 (2), 9778044 (2) (see all 13)
    lymphoblastic leukemia acute childhood 38.2 1 7478554 (1)
    tumors 0 8 11069299 (3), 7478554 (2), 18082256 (1), 9811890 (1)
    lymphoma 0 4 11069299 (3)
    cancer 0 4 12750702 (2), 14659882 (1), 7719228 (1)


    Export disorders for TLX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TLX1 gene, integrated from 10 sources (see all 91):
    (articles sorted by number of sources associating them with TLX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. (PubMed id 1676542)1, 2, 3 Hatano M.... Korsmeyer S.J. (Science 1991)
    2. Multiple negative elements contribute to repression of the HOX11 proto-oncogene. (PubMed id 9778044)1, 2, 9 Brake R.L.... Watt P.M. (Oncogene 1998)
    3. Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells. (PubMed id 1352396)1, 2, 9 Lu M.... Ho A.D. (Oncogene 1992)
    4. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PubMed id 17303350)1, 2, 9 Greene W.K....Bellgard M.I. (Gene 2007)
    5. Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line. (PubMed id 10393251)1, 2, 9 Watt P.M.... Kees U.R. (Gene 1999)
    6. The tcl-3 proto-oncogene altered by chromosomal translocation in T- cell leukemia codes for a homeobox protein. (PubMed id 1717256)1, 2, 9 Lu M.... Ho A.D. (EMBO J. 1991)
    7. MEIS proteins as partners of the TLX1/HOX11 oncoprotein. (PubMed id 19559479)1, 2, 9 Milech N....Watt P.M. (Leuk. Res. 2010)
    8. HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. (PubMed id 1681546)1, 2, 9 Kennedy M.A.... Rabbitts T.H. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    9. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    10. HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. (PubMed id 9009195)1, 9 Kawabe T....Korsmeyer S.J. (Nature 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3195 HGNC: 5056 AceView: TLX1 Ensembl:ENSG00000107807 euGenes: HUgn3195
    ECgene: TLX1 Kegg: 3195 H-InvDB: TLX1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TLX1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLX1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TLX1 gene:
    Search GeneIP for patents involving TLX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TLX1   OriGene RNAi products in human, mouse, rat for TLX1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TLX1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TLX1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TLX1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TLX1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TLX1   OriGene Custom Protein Services for TLX1  

     
     
     Block miRNA regulation of human, mouse, rat TLX1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TLX1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLX1 Predesigned siRNA for gene silencing in human, mouse, rat TLX1
     QuantiFast Probe-based Assays in human, mouse, rat TLX1 QuantiTect SYBR Green Assays in human, mouse, rat TLX1
     PCR Arrays including human, mouse, rat TLX1 Search Chromatin IP Primers for TLX1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLX1  GeneGlobe Interaction Network for TLX1
     Regulatory tfbs in TLX1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TLX1 GenScript cDNA clones with any tag delivered in your preferred vector for TLX1
     GenScript Custom Assay Services for TLX1 GenScript Custom overexpressing Cell Line Services for TLX1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TLX1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TLX1 antibodies
     TLX1 lysates
     Antibodies for TLX1
     See all of Abcam's Antibodies, Kits and Proteins for TLX1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TLX1
     Antibodies for TLX1
     ELISAs for TLX1
     CLIAs for TLX1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TLX1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLX1
     SwitchGear 3'UTR luciferase reporter plasmids for TLX1
     SwitchGear Promoter luciferase reporter plasmids for TLX1
     ThermoFisher Antibodies for TLX1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLX1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLX1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLX1
     LSBio Antibodies in human, mouse, rat for TLX1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TLX1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4