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Aliases for TLX1 Gene

Aliases for TLX1 Gene

  • T-Cell Leukemia Homeobox 1 2 3 5
  • Homeo Box 11 (T-Cell Lymphoma 3-Associated Breakpoint) 2 2
  • T-Cell Leukemia/Lymphoma Protein 3 3 4
  • Homeobox Protein Hox-11 3 4
  • Proto-Oncogene TCL-3 3 4
  • HOX11 3 4
  • TCL3 3 4
  • Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint, Homologous To Drosophila Notch) 3
  • Homeo Box-11 (T-Cell Leukemia-3 Associated Breakpoint 2
  • Homologous To Drosophila Notch) 2
  • T-Cell Leukemia, Homeobox 1 2

External Ids for TLX1 Gene

Previous HGNC Symbols for TLX1 Gene

  • TCL3
  • HOX11

Previous GeneCards Identifiers for TLX1 Gene

  • GC10P101783
  • GC10P102123
  • GC10P103021
  • GC10P102554
  • GC10P102880
  • GC10P096520
  • GC10P102889

Summaries for TLX1 Gene

Entrez Gene Summary for TLX1 Gene

  • This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for TLX1 Gene

TLX1 (T-Cell Leukemia Homeobox 1) is a Protein Coding gene. Diseases associated with TLX1 include Precursor T-Cell Acute Lymphoblastic Leukemia and T-Cell Leukemia. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is BARX2.

UniProtKB/Swiss-Prot for TLX1 Gene

  • Controls the genesis of the spleen. Binds to the DNA sequence 5-GGCGGTAAGTGG-3.

Gene Wiki entry for TLX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLX1 Gene

Genomics for TLX1 Gene

Regulatory Elements for TLX1 Gene

Enhancers for TLX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TLX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLX1 Gene

101,130,505 bp from pter
101,137,789 bp from pter
7,285 bases
Plus strand

Genomic View for TLX1 Gene

Genes around TLX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLX1 Gene

Proteins for TLX1 Gene

  • Protein details for TLX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell leukemia homeobox protein 1
    Protein Accession:
    Secondary Accessions:
    • A1L4G3
    • O75699
    • Q5VXP2
    • Q9HCA0
    • Q9UD59

    Protein attributes for TLX1 Gene

    330 amino acids
    Molecular mass:
    34365 Da
    Quaternary structure:
    • Interacts with MEIS1, MEIS2, PBX1, PBX2 and PBX3.
    • TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity.

    Alternative splice isoforms for TLX1 Gene


neXtProt entry for TLX1 Gene

Proteomics data for TLX1 Gene at MOPED

Post-translational modifications for TLX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLX1 Gene

No data available for DME Specific Peptides for TLX1 Gene

Domains & Families for TLX1 Gene

Gene Families for TLX1 Gene

Protein Domains for TLX1 Gene

Suggested Antigen Peptide Sequences for TLX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with TLX1: view

Function for TLX1 Gene

Molecular function for TLX1 Gene

UniProtKB/Swiss-Prot Function:
Controls the genesis of the spleen. Binds to the DNA sequence 5-GGCGGTAAGTGG-3.

Gene Ontology (GO) - Molecular Function for TLX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with TLX1: view
genes like me logo Genes that share phenotypes with TLX1: view

Human Phenotype Ontology for TLX1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TLX1 Gene

MGI Knock Outs for TLX1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TLX1 Gene

Localization for TLX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLX1 Gene

Subcellular locations from

Jensen Localization Image for TLX1 Gene COMPARTMENTS Subcellular localization image for TLX1 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TLX1 Gene

Pathways & Interactions for TLX1 Gene

genes like me logo Genes that share pathways with TLX1: view

Pathways by source for TLX1 Gene

1 KEGG pathway for TLX1 Gene

Gene Ontology (GO) - Biological Process for TLX1 Gene


No data available for SIGNOR curated interactions for TLX1 Gene

Drugs & Compounds for TLX1 Gene

(3) Drugs for TLX1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TLX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TLX1: view

Transcripts for TLX1 Gene

mRNA/cDNA for TLX1 Gene

Unigene Clusters for TLX1 Gene

T-cell leukemia homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLX1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4
SP1: - -
SP2: -
SP3: -

Relevant External Links for TLX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLX1 Gene

mRNA expression in normal human tissues for TLX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLX1 Gene

This gene is overexpressed in Spleen (x42.9) and Minor Salivary Gland (x7.5).

Protein differential expression in normal tissues from HIPED for TLX1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLX1 Gene

SOURCE GeneReport for Unigene cluster for TLX1 Gene Hs.89583

genes like me logo Genes that share expression patterns with TLX1: view

Protein tissue co-expression partners for TLX1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TLX1 Gene

Orthologs for TLX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TLX1 35
  • 91.72 (n)
  • 95.45 (a)
TLX1 36
  • 94 (a)
(Canis familiaris)
Mammalia TLX1 35
  • 91.11 (n)
  • 96.06 (a)
TLX1 36
  • 95 (a)
(Mus musculus)
Mammalia Tlx1 35
  • 89.29 (n)
  • 96.36 (a)
Tlx1 16
Tlx1 36
  • 96 (a)
(Pan troglodytes)
Mammalia TLX1 35
  • 98.96 (n)
  • 99.22 (a)
TLX1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tlx1 35
  • 89.39 (n)
  • 96.67 (a)
(Monodelphis domestica)
Mammalia TLX1 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia TLX1 36
  • 77 (a)
(Gallus gallus)
Aves TLX1 35
  • 77.7 (n)
  • 78.31 (a)
TLX1 36
  • 94 (a)
(Anolis carolinensis)
Reptilia TLX1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tlx1 35
  • 70.01 (n)
  • 76.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia tlx1-A-prov 35
(Danio rerio)
Actinopterygii tlx1 35
  • 67.95 (n)
  • 71.93 (a)
tlx3a 35
tlx1 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta C15 37
  • 71 (a)
C15 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea ceh-9 36
  • 35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1269 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for TLX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLX1 Gene

Gene Tree for TLX1 (if available)
Gene Tree for TLX1 (if available)

Paralogs for TLX1 Gene

(2) SIMAP similar genes for TLX1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLX1: view

Variants for TLX1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TLX1 Gene

Variant ID Type Subtype PubMed ID
nsv508603 CNV Loss 20534489
nsv831966 CNV Gain 17160897
nsv895966 CNV Loss 21882294

Variation tolerance for TLX1 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for TLX1 Gene

Disorders for TLX1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TLX1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
t-cell leukemia
  • leukemia t-cell
lymphoblastic leukemia
  • acute lymphocytic leukemia
split hand-split foot malformation
  • split hand foot malformation
- elite association - COSMIC cancer census association via MalaCards
Search TLX1 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. {ECO:0000269 PubMed:1676542, ECO:0000269 PubMed:1681546, ECO:0000269 PubMed:1717256}.

Relevant External Links for TLX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TLX1: view

No data available for Genatlas for TLX1 Gene

Publications for TLX1 Gene

  1. Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. (PMID: 1676542) Hatano M. … Korsmeyer S.J. (Science 1991) 2 3 4 67
  2. MEIS proteins as partners of the TLX1/HOX11 oncoprotein. (PMID: 19559479) Milech N. … Watt P.M. (Leuk. Res. 2010) 3 23
  3. Transcriptional regulation of FHL1 by TLX1/HOX11 is dosage, cell-type and promoter context-dependent. (PMID: 18073142) Rice K.L. … Greene W.K. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Thymic adult T-cell acute lymphoblastic leukemia stratified in standard- and high-risk group by aberrant HOX11L2 expression: experience of the German multicenter ALL study group. (PMID: 18368072) Baak U. … Burmeister T. (Leukemia 2008) 3 23
  5. A promoter with bidirectional activity is located between TLX1/HOX11 and a divergently transcribed novel human gene. (PMID: 17303350) Greene W.K. … Bellgard M.I. (Gene 2007) 3 23

Products for TLX1 Gene

Sources for TLX1 Gene