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Aliases for TLR9 Gene

Aliases for TLR9 Gene

  • Toll-Like Receptor 9 2 3
  • CD289 Antigen 4
  • CD289 3

External Ids for TLR9 Gene

Summaries for TLR9 Gene

Entrez Gene Summary for TLR9 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR9 Gene

TLR9 (Toll-Like Receptor 9) is a Protein Coding gene. Diseases associated with TLR9 include meningococcal meningitis and ocular toxoplasmosis. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include transmembrane signaling receptor activity and siRNA binding. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR9 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

Gene Wiki entry for TLR9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR9 Gene

Genomics for TLR9 Gene

Genomic Location for TLR9 Gene

Start:
52,221,080 bp from pter
End:
52,226,163 bp from pter
Size:
5,084 bases
Orientation:
Minus strand

Genomic View for TLR9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR9 Gene

Regulatory Elements for TLR9 Gene

Proteins for TLR9 Gene

  • Protein details for TLR9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR96-TLR9_HUMAN
    Recommended name:
    Toll-like receptor 9
    Protein Accession:
    Q9NR96
    Secondary Accessions:
    • B3Y661
    • D1CS56
    • Q6UVZ2
    • Q9HD68
    • Q9HD69
    • Q9HD70
    • Q9NYC2
    • Q9NYC3

    Protein attributes for TLR9 Gene

    Size:
    1032 amino acids
    Molecular mass:
    115860 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.

    Alternative splice isoforms for TLR9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR9 Gene

Proteomics data for TLR9 Gene at MOPED

Post-translational modifications for TLR9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn64, Asn129, Asn200, Asn210, Asn242, Asn300, Asn340, Asn469, Asn474, Asn513, Asn567, Asn694, and Asn731

Other Protein References for TLR9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TLR9 Gene

Domains for TLR9 Gene

Gene Families for TLR9 Gene

HGNC:
  • CD :CD molecules
IUPHAR :

Protein Domains for TLR9 Gene

UniProtKB/Swiss-Prot:

TLR9_HUMAN
Domain:
  • Contains 1 TIR domain.:
    • Q9NR96
Family:
  • Belongs to the Toll-like receptor family.:
    • Q9NR96
Similarity:
  • Contains 26 LRR (leucine-rich) repeats.:
    • Q9NR96
genes like me logo Genes that share domains with TLR9: view

Function for TLR9 Gene

Molecular function for TLR9 Gene

UniProtKB/Swiss-Prot Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.

Gene Ontology (GO) - Molecular Function for TLR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005149 interleukin-1 receptor binding IPI 12925853
GO:0005515 protein binding --
GO:0035197 siRNA binding IMP 15723075
genes like me logo Genes that share ontologies with TLR9: view
genes like me logo Genes that share phenotypes with TLR9: view

Animal Models for TLR9 Gene

MGI Knock Outs for TLR9:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TLR9 Gene

Localization for TLR9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR9 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR9 Gene COMPARTMENTS Subcellular localization image for TLR9 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
endosome 4
golgi apparatus 4
lysosome 4
plasma membrane 4
vacuole 4
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region NAS 11130078
GO:0005737 cytoplasm IDA 19740627
GO:0005764 lysosome ISS --
GO:0005768 endosome ISS --
genes like me logo Genes that share ontologies with TLR9: view

Pathways for TLR9 Gene

genes like me logo Genes that share pathways with TLR9: view

Gene Ontology (GO) - Biological Process for TLR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin TAS 15356140
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with TLR9: view

Compounds for TLR9 Gene

(2) Drugbank Compounds for TLR9 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Chloroquine
  • Chloraquine
54-05-7 target
Hydroxychloroquine
118-42-3 target antagonist

(1) IUPHAR Ligand for TLR9 Gene

Ligand Type Action Affinity Pubmed IDs
CpG Agonist Agonist

(28) Novoseek inferred chemical compound relationships for TLR9 Gene

Compound -log(P) Hits PubMed IDs
loxoribine 82.1 2
resiquimod 77.5 3
bafilomycin a 72.6 1
phosphorothioate 68.4 10
chloroquine 67.6 12
genes like me logo Genes that share compounds with TLR9: view

Transcripts for TLR9 Gene

mRNA/cDNA for TLR9 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(543) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLR9 Gene

Toll-like receptor 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR9 Gene

No ASD Table

Relevant External Links for TLR9 Gene

GeneLoc Exon Structure for
TLR9
ECgene alternative splicing isoforms for
TLR9

Expression for TLR9 Gene

mRNA expression in normal human tissues for TLR9 Gene

mRNA expression in normal human tissues for TLR9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TLR9 Gene

SOURCE GeneReport for Unigene cluster for TLR9 Gene Hs.87968

mRNA Expression by UniProt/SwissProt for TLR9 Gene

Q9NR96-TLR9_HUMAN
Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver
genes like me logo Genes that share expressions with TLR9: view

Orthologs for TLR9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR9 36
  • 99.29 (n)
  • 99.32 (a)
TLR9 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TLR9 36
  • 83.69 (n)
  • 80.14 (a)
TLR9 37
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TLR9 36
  • 85.23 (n)
  • 81.83 (a)
TLR9 37
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tlr9 36
  • 77.72 (n)
  • 75.56 (a)
Tlr9 16
Tlr9 37
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tlr9 36
  • 77.65 (n)
  • 74.15 (a)
chicken
(Gallus gallus)
Aves TLR21 37
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494387 36
  • 45.66 (n)
  • 37.37 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr9 36
  • 48.88 (n)
  • 40.73 (a)
tlr9 37
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7896 38
  • 28 (a)
Species with no ortholog for TLR9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR9 Gene

ENSEMBL:
Gene Tree for TLR9 (if available)
TreeFam:
Gene Tree for TLR9 (if available)

Paralogs for TLR9 Gene

Paralogs for TLR9 Gene

Selected SIMAP similar genes for TLR9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TLR9: view

Variants for TLR9 Gene

Sequence variations from dbSNP and Humsavar for TLR9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs187084 -- 52,227,015(-) gccct(C/T)aagaa upstream-variant-2KB
rs352139 -- 52,224,356(-) GAGGT(A/G)GAGCT intron-variant
rs352140 -- 52,222,681(+) AGTCG(A/C/T)GGTAG synonymous-codon, reference
rs352144 -- 52,227,452(-) GGCTC(A/C)GGGCA upstream-variant-2KB
rs445676 -- 52,221,376(-) CGCTA(C/T)GTGCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TLR9 Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv460537 CNV Loss 19166990
nsv508218 CNV Loss 20534489
nsv508926 CNV Insertion 20534489
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv482084 CNV Gain 20164927

Relevant External Links for TLR9 Gene

HapMap Linkage Disequilibrium report
TLR9
Human Gene Mutation Database (HGMD)
TLR9

Disorders for TLR9 Gene

(46) Novoseek inferred disease relationships for TLR9 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 58.4 18
autoimmune diseases 50.5 14
autoimmunity 42 1
inflammation 40.8 9
virus infection 38.3 8

Relevant External Links for TLR9

Genetic Association Database (GAD)
TLR9
Human Genome Epidemiology (HuGE) Navigator
TLR9
genes like me logo Genes that share disorders with TLR9: view

No data available for UniProtKB/Swiss-Prot for TLR9 Gene

Publications for TLR9 Gene

  1. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. (PMID: 12573264) Lazarus R. … Weiss S.T. (Genomics 2003) 3 23 49
  2. An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. (PMID: 14987294) Noguchi E. … Arinami T. (Clin. Exp. Allergy 2004) 3 23 49
  3. Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus. (PMID: 15730519) Hur J.W. … Bae S.C. (Tissue Antigens 2005) 3 23 49
  4. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. (PMID: 15878652) Kikuchi K. … Gershwin M.E. (J. Autoimmun. 2005) 3 23 49
  5. Common human Toll-like receptor 9 polymorphisms and haplotypes: association with atopy and functional relevance. (PMID: 16164440) BerghAPfer B. … Hackstein H. (Clin. Exp. Allergy 2005) 3 23 49

Products for TLR9 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TLR9
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR9
  • Block miRNA regulation of TLR9 using miScript Target Protectors
  • Addgene plasmids for TLR9

Sources for TLR9 Gene

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