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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLR9 Gene

protein-coding   GIFtS: 65
GCID: GC03M052255

Toll-Like Receptor 9

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Toll-Like Receptor 91 2
CD2892
CD289 Antigen3

External Ids:    HGNC: 156331   Entrez Gene: 541062   Ensembl: ENSG000002397327   OMIM: 6054745   UniProtKB: Q9NR963   

Export aliases for TLR9 gene to outside databases

Previous GC identifers: GC03M051347 GC03M051507 GC03M052111 GC03M052213 GC03M052230


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR9 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially
expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes.
Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG
dinucleotides in bacterial DNA to mount an innate immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLR9 Gene: 
TLR9 (toll-like receptor 9) is a protein-coding gene. Diseases associated with TLR9 include meningococcal meningitis, and herpetic keratitis, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response TLR signaling pathways. GO annotations related to this gene include interleukin-1 receptor binding and siRNA binding. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a
nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts
via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls
lymphocyte response to Helicobacter infection

Gene Wiki entry for TLR9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR9 gene promoter:
         CREB   STAT1   AP-1   deltaCREB   ATF-2   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLR9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.3

TLR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052255:  view genomic region     (about GC identifiers)

Start:
52,255,096 bp from pter      End:
52,273,183 bp from pter
Size:
18,088 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96 (See protein sequence)
Recommended Name: Toll-like receptor 9 precursor  
Size: 1032 amino acids; 115860 Da
Subunit: Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane
domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of
TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this
interaction is required for proper folding in the endoplasmic reticulum
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity).
Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity).
Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By
similarity)
Secondary accessions: B3Y661 D1CS56 Q6UVZ2 Q9HD68 Q9HD69 Q9HD70 Q9NYC2 Q9NYC3
Alternative splicing: 5 isoforms:  Q9NR96-1   Q9NR96-2   Q9NR96-3   Q9NR96-4   Q9NR96-5   

Explore the universe of human proteins at neXtProt for TLR9: NX_Q9NR96

Explore proteomics data for TLR9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NR96

  • TLR9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLR9 Protein Expression
    REFSEQ proteins: NP_059138.1  
    ENSEMBL proteins: 
     ENSP00000353874   ENSP00000471046  
    Reactome Protein details: Q9NR96
    Human Recombinant Protein Products for TLR9: 
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    OriGene Protein Over-expression Lysate for TLR9
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    Novus Biologicals TLR9 Proteins
    Novus Biologicals TLR9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR9 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region NAS11130078
    GO:0005737cytoplasm IDA19740627
    GO:0005764lysosome ISS--
    GO:0005768endosome ISS--

    TLR9 for ontologies           About GeneDecksing



    TLR9 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TLR9 

    Assay Products for TLR9: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLR9 
    Cloud-Clone Corp. CLIAs for TLR9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR9 
    Toll-like receptor family

    4 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR027181 TLR9

    Graphical View of Domain Structure for InterPro Entry Q9NR96

    ProtoNet protein and cluster: Q9NR96

    1 Blocks protein domain: IPB000157 TIR domain

    UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 26 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    TLR9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR9_HUMAN, Q9NR96
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a
    nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts
    via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls
    lymphocyte response to Helicobacter infection

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005149interleukin-1 receptor binding IPI12925853
    GO:0005515protein binding ----
    GO:0035197siRNA binding IMP15723075
         
    TLR9 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Tlr9):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    TLR9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tlr9tm1Aki for TLR9

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLR9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLR9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR9 

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    hsa-miR-1909*
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    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TLR9 (NM_017442)
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                         Customized lentivirus expression plasmids for stable overexpression of TLR9 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLR9 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Chagas disease (American trypanosomiasis)0.33
    Toll-like receptor signaling pathway0.93
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    4TRAF6 Mediated Induction of proinflammatory cytokines
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll Like Receptor 9 (TLR9) Cascade0.89
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.92
    Toll-Like Receptors Cascades0.87
    MyD88 dependent cascade initiated on endosome0.92
    5Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52
    NOD-like Receptor Signaling Pathways0.59
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TLR9
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/7 R&D Systems Pathways for TLR9 (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR9 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR9
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR9
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR9
        Immune response TLR signaling pathways

    1 BioSystems Pathway for TLR9
        Toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR9 
        NF-kB (NFkB) Pathway

    5/18        Reactome Pathways for TLR9 (see all 18)
        TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Toll-Like Receptors Cascades
    Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
    IRS-related events


    5/7         Kegg Pathways  (Kegg details for TLR9) (see all 7):
        Toll-like receptor signaling pathway
    Chagas disease (American trypanosomiasis)
    African trypanosomiasis
    Malaria
    Tuberculosis


    TLR9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/58 Interacting proteins for TLR9 (Q9NR963 ENSP000003538744) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGERQ151093I2D: score=1 
    ENSG00000206320Q151093I2D: score=1 
    ENSG00000229058Q151093I2D: score=1 
    ENSG00000230514Q151093I2D: score=1 
    ENSG00000231268Q151093I2D: score=1 
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002237response to molecule of bacterial origin TAS15356140
    GO:0002755MyD88-dependent toll-like receptor signaling pathway IEA--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    TLR9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TLR9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TLR9

    Browse Tocris compounds for TLR9

    2 DrugBank Compounds for TLR9    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ChloroquineChloraquine (see all 6)54-05-7target--14579285 16849519 15762869 15307186 16148144
    Hydroxychloroquine-- 118-42-3targetantagonist14579285 18220957

    1 IUPHAR Ligand for TLR9 (TLR9)    About this table 
    LigandTypeActionAffinityPubmed IDs
    CpG
    AgonistAgonist11130078

    10/28 Novoseek inferred chemical compound relationships for TLR9 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    loxoribine 82.1 2 19685493 (1), 15778362 (1)
    resiquimod 77.5 5 19183807 (1), 15827165 (1), 15778362 (1)
    bafilomycin a 72.6 1 19299739 (1)
    phosphorothioate 68.4 24 18342006 (3), 15634876 (1), 20348392 (1), 15879106 (1) (see all 8)
    chloroquine 67.6 20 15762869 (1), 16740161 (1), 17893430 (1), 14996414 (1) (see all 12)
    poly(i-c) 64.9 1 16299289 (1)
    flagellin 61.5 10 17586660 (2), 18256754 (1), 18571707 (1), 18819410 (1) (see all 7)
    lipoteichoic acid 58.1 2 18571707 (1), 16175622 (1)
    phosphodiester 58 31 16421948 (5), 18342006 (3), 18656540 (3), 17382246 (1) (see all 9)
    polyinosinic-polycytidylic acid 54.9 5 19578865 (1), 18571707 (1), 16818783 (1), 17395700 (1)

    Search CenterWatch for drugs/clinical trials and news about TLR9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLR9 gene (2 alternative transcripts): 
    NM_017442.3  NM_138688.1  

    Unigene Cluster for TLR9:

    Toll-like receptor 9
    Hs.87968  [show with all ESTs]
    Unigene Representative Sequence: NM_017442
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360658(uc003dda.2) ENST00000597542
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR9
    Sirion Biotech Customized lentivirus for stable overexpression of TLR9 
                         Customized lentivirus expression plasmids for stable overexpression of TLR9 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR9

    Additional mRNA sequence: 

    AB045180.1 AB445673.1 AF245704.1 AF246972.1 AF259262.1 AF259263.1 AY359085.1 BC032713.1 

    2 DOTS entries:

    DT.86821044  DT.95264846 

    24/543 AceView cDNA sequences (see all 543):

    CR590947 AI760680 BM763490 BE272038 CR623453 CF529870 AA887698 BI963999 
    BC000327 CR626408 BQ888942 BU629872 AI088343 AA580444 BQ879863 BM459189 
    AI193757 CF139790 BQ683577 AB045180 AF245704 AF259263 BM809522 BQ184602 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLR9 expression in normal human tissues (normalized intensities)      TLR9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TLR9 Expression
    About this image


    TLR9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lymph (Hematopoietic System)    fully expand to see all 3 entries
             lymph node ; non-germinal center cells   
             LYMPH NODE   

    See TLR9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLR9

    SOURCE GeneReport for Unigene cluster: Hs.87968

    UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96
    Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in
    plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also
    detected in lung and liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR9 (see all 11): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TLR9 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr91 , 5 toll-like receptor 91, 5 77.77(n)1
    75.75(a)1
      9 (57.46 cM)5
    818971  NM_031178.21  NP_112455.21 
     1062225985 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    22(a)
    possible ortholog
    2(122504100-122506901)
    zebrafish
    (Danio rerio)
    Actinopterygii tlr91 toll-like receptor 9 48.78(n)
    40.82(a)
      403128  NM_001130594.1  NP_001124066.1 


    ENSEMBL Gene Tree for TLR9 (if available)
    TreeFam Gene Tree for TLR9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLR9 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR52  TLR102  TLR42  TLR82  
    TLR62  TLR32  TLR22  
    2 SIMAP similar genes for TLR9 using alignment to 7 protein entries:     TLR9_HUMAN (see all proteins):
    TLR8    TLR7

    TLR9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/445 SNPs in TLR9 are shown (see all 445)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360784
    A colorectal cancer sample4--see VAR_0360782 T M mis40--------
    VAR_0360774
    A colorectal cancer sample4--see VAR_0360772 R H mis40--------
    rs1416389371,2
    C--52254635(+) TCACCC/TCTCCA 1 -- int10--------
    rs1462224141,2
    --52254656(+) AATTCA/GTTCTA 1 -- int10--------
    rs1825197431,2
    --52254710(+) CTTTGC/TTGAGC 1 -- int10--------
    rs57438491,2
    C,F,H--52254716(-) TCTGGC/TGCTCA 1 -- int114Minor allele frequency- T:0.05NA EU NS EA CSA WA 1292
    rs754318071,2
    F--52254740(+) TGCAGC/TTTCTC 1 -- int11Minor allele frequency- T:0.50NA 4
    rs1401229221,2
    --52254830(+) GTCTGC/TCAGGT 1 -- int10--------
    rs1437662321,2
    --52254920(+) CCAAGA/GCCACA 1 -- int10--------
    rs1131361371,2
    C--52255103(+) GCCTTG/CGGTAG 1 -- ut311Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for TLR9 (52255096 - 52273183 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TLR9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508926CNV Insertion20534489
    nsv834695CNV Loss17160897
    nsv460537CNV Loss19166990
    nsv876789CNV Loss21882294
    nsv508218CNV Loss20534489
    nsv470572CNV Loss18288195
    nsv834694CNV Gain17160897
    nsv482084CNV Gain20164927
    dgv5136n71CNV Gain21882294
    nsv519445CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): TLR9
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605474    OMIM disorders: --

    20/129 diseases for TLR9 (see all 129):    About MalaCards
    meningococcal meningitis    herpetic keratitis    pouchitis    common variable immune deficiency
    septic arthritis    keratitis    bacterial meningitis    molluscum contagiosum
    stevens-johnson syndrome    toxic epidermal necrolysis    idiopathic interstitial pneumonia    hyper ige syndrome
    chronic graft versus host disease    lupus nephritis    alcoholic hepatitis    filariasis
    influenza    lyme disease    herpes simplex    burkitt's lymphoma

    7 diseases from the University of Copenhagen DISEASES database for TLR9:
    Lupus erythematosus     Connective tissue disease     Malaria     Hypersensitivity reaction type I disease
    Cancer     Asthma     Common variable immunodeficiency

    TLR9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/46 Novoseek inferred disease relationships for TLR9 gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 58.4 27 19130296 (2), 17516623 (2), 18613842 (1), 18262306 (1) (see all 16)
    autoimmune diseases 50.5 15 17961163 (2), 18513998 (2), 19587007 (2), 18613842 (1) (see all 11)
    autoimmunity 42 1 12740574 (1)
    inflammation 40.8 9 14632662 (1), 19129482 (1), 15843514 (1), 17145922 (1) (see all 9)
    virus infection 38.3 8 15592841 (2), 17360657 (1), 19129482 (1), 19644151 (1) (see all 7)
    infectious disease 38 5 16365416 (1), 17854429 (1), 17330401 (1), 18457466 (1) (see all 5)
    allergy 36.7 4 16164440 (1), 18071654 (1), 19630573 (1)
    necrosis 34.8 11 16510559 (1), 14688201 (1), 15507621 (1), 18922969 (1) (see all 10)
    tumors 32.7 94 19319670 (6), 15631627 (5), 17675511 (4), 17440926 (4) (see all 37)
    asthma 30.4 13 18312481 (2), 19096003 (2), 19034349 (2), 16164440 (1) (see all 6)

    Genetic Association Database (GAD): TLR9
    Human Genome Epidemiology (HuGE) Navigator: TLR9 (111 documents)

    Export disorders for TLR9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLR9 gene, integrated from 9 sources (see all 787):
    (articles sorted by number of sources associating them with TLR9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 9 Du X.... Beutler B. (2000)
    2. TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression. (PubMed id 19284650)1, 4, 9 Campino S....Kwiatkowski D.P. (2009)
    3. Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. (PubMed id 19130296)1, 4, 9 Xu C.J....Ye D.Q. (2009)
    4. Common human Toll-like receptor 9 polymorphisms and haplotypes: association with atopy and functional relevance. (PubMed id 16164440)1, 4, 9 Berghofer B....Hackstein H. (2005)
    5. TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. (PubMed id 17914947)1, 4, 9 Hong J....Krissansen G.W. (2007)
    6. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. (PubMed id 17344245)1, 4, 9 Tao K....Yasutomo K. (2007)
    7. Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity. (PubMed id 16849519)1, 7, 9 Merrell M.A....Selander K.S. (2006)
    8. Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus. (PubMed id 16575840)1, 4, 9 De Jager P.L....Rioux J.D. (2006)
    9. Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. (PubMed id 16125159)1, 4, 9 Hamann L....Schumann R.R. (2006)
    10. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. (PubMed id 15878652)1, 4, 9 Kikuchi K....Gershwin M.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54106 HGNC: 15633 AceView: PTK9LandTLR9 Ensembl:ENSG00000239732 euGenes: HUgn54106
    ECgene: TLR9 Kegg: 54106 H-InvDB: TLR9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLR9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLR9 gene:
    Search GeneIP for patents involving TLR9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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