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TLR9 Gene

protein-coding   GIFtS: 65
GCID: GC03M052255

Toll-Like Receptor 9

  See TLR9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Toll-Like Receptor 91 2
CD2892
CD289 Antigen3

External Ids:    HGNC: 156331   Entrez Gene: 541062   Ensembl: ENSG000002397327   OMIM: 6054745   UniProtKB: Q9NR963   

Export aliases for TLR9 gene to outside databases

Previous GC identifers: GC03M051347 GC03M051507 GC03M052111 GC03M052213 GC03M052230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLR9 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially
expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes.
Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG
dinucleotides in bacterial DNA to mount an innate immune response. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLR9 Gene:
TLR9 (toll-like receptor 9) is a protein-coding gene. Diseases associated with TLR9 include meningococcal meningitis, and ocular toxoplasmosis. GO annotations related to this gene include transmembrane signaling receptor activity and siRNA binding. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a
nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts
via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls
lymphocyte response to Helicobacter infection

Gene Wiki entry for TLR9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLR9 gene promoter:
         CREB   STAT1   AP-1   deltaCREB   ATF-2   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR9 promoter sequence
   Search Chromatin IP Primers for TLR9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.3

TLR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052255:  view genomic region     (about GC identifiers)

Start:
52,255,096 bp from pter      End:
52,273,183 bp from pter
Size:
18,088 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96 (See protein sequence)
Recommended Name: Toll-like receptor 9 precursor  
Size: 1032 amino acids; 115860 Da
Subunit: Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane
domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of
TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this
interaction is required for proper folding in the endoplasmic reticulum
Secondary accessions: B3Y661 D1CS56 Q6UVZ2 Q9HD68 Q9HD69 Q9HD70 Q9NYC2 Q9NYC3
Alternative splicing: 5 isoforms:  Q9NR96-1   Q9NR96-2   Q9NR96-3   Q9NR96-4   Q9NR96-5   

Explore the universe of human proteins at neXtProt for TLR9: NX_Q9NR96

Explore proteomics data for TLR9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn64, Asn129, Asn200, Asn210, Asn242, Asn300, Asn340, Asn469, Asn474, Asn513,
                                 Asn567, Asn694, Asn731
  • Modification sites at PhosphoSitePlus

  • See TLR9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_059138.1  
    ENSEMBL proteins: 
     ENSP00000353874   ENSP00000471046  
    Reactome Protein details: Q9NR96

    TLR9 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TLR9
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    Cloud-Clone Corp. Proteins for TLR9

     
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    Search eBioscience for ELISAs for TLR9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR9
    Toll-like receptor family

    4 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR027181 TLR9

    Graphical View of Domain Structure for InterPro Entry Q9NR96

    ProtoNet protein and cluster: Q9NR96

    1 Blocks protein domain: IPB000157 TIR domain

    UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 26 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TLR9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR9_HUMAN, Q9NR96
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a
    nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts
    via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls
    lymphocyte response to Helicobacter infection

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005149interleukin-1 receptor binding IPI12925853
    GO:0005515protein binding ----
    GO:0035197siRNA binding IMP15723075
         
    Find genes that share ontologies with TLR9           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Tlr9):
     cellular  digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    Find genes that share phenotypes with TLR9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tlr9tm1Aki for TLR9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLR9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLR9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR9

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    1 qRT-PCR Assays for microRNA that regulate TLR9:
    hsa-miR-1909*
    SwitchGear 3'UTR luciferase reporter plasmidTLR9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TLR9
    Predesigned siRNA for gene silencing in human, mouse, rat TLR9

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TLR9 (NM_017442)
    Sino Biological Human cDNA Clone for TLR9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR9
    Addgene plasmids for TLR9 

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-11917) for TLR9 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLR9_HUMAN, Q9NR96: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity).
    Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity).
    Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    endosome4
    golgi apparatus4
    lysosome4
    plasma membrane4
    vacuole4
    nucleus2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005576extracellular region NAS11130078
    GO:0005737cytoplasm IDA19740627
    GO:0005764lysosome ISS--
    GO:0005768endosome ISS--

    Find genes that share ontologies with TLR9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLR9 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    2Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    IRS-related events triggered by IGF1R0.92
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PI3K Cascade0.87
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.80
    3Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88 dependent cascade initiated on endosome0.69
    Toll Like Receptor 9 (TLR9) Cascade0.93
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    4NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    NOD-like Receptor Signaling Pathways0.58
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    5NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72


    Find genes that share SuperPaths with TLR9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TLR9 (see all 7)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLR9 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR9
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR9
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR9
        Immune response TLR signaling pathways

    2 BioSystems Pathways for TLR9
        Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR9
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for TLR9 (see all 6)
        PI3K Cascade
    Toll Like Receptor 9 (TLR9) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Trafficking and processing of endosomal TLR


    Selected Kegg Pathways  (Kegg details for TLR9) (see all 7):
        Toll-like receptor signaling pathway
    Chagas disease (American trypanosomiasis)
    African trypanosomiasis
    Malaria
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR9 (see all 11): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLR9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLR9 (Q9NR963 ENSP000003538744) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGERQ151093I2D: score=1 
    ENSG00000206320Q151093I2D: score=1 
    ENSG00000229058Q151093I2D: score=1 
    ENSG00000230514Q151093I2D: score=1 
    ENSG00000231268Q151093I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002237response to molecule of bacterial origin TAS15356140
    GO:0002755MyD88-dependent toll-like receptor signaling pathway IEA--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    Find genes that share ontologies with TLR9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TLR9
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLR9

    2 DrugBank Compounds for TLR9    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ChloroquineChloraquine (see all 6)54-05-7target--14579285 16849519 15762869 15307186 16148144
    Hydroxychloroquine-- 118-42-3targetantagonist14579285 18220957

    1 IUPHAR Ligand for TLR9 (TLR9)    About this table
    LigandTypeActionAffinityPubmed IDs
    CpG
    AgonistAgonist11130078

    Selected Novoseek inferred chemical compound relationships for TLR9 gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    loxoribine 82.1 2 19685493 (1), 15778362 (1)
    resiquimod 77.5 5 19183807 (1), 15827165 (1), 15778362 (1)
    bafilomycin a 72.6 1 19299739 (1)
    phosphorothioate 68.4 24 18342006 (3), 15634876 (1), 20348392 (1), 15879106 (1) (see all 8)
    chloroquine 67.6 20 15762869 (1), 16740161 (1), 17893430 (1), 14996414 (1) (see all 12)
    poly(i-c) 64.9 1 16299289 (1)
    flagellin 61.5 10 17586660 (2), 18256754 (1), 18571707 (1), 18819410 (1) (see all 7)
    lipoteichoic acid 58.1 2 18571707 (1), 16175622 (1)
    phosphodiester 58 31 16421948 (5), 18342006 (3), 18656540 (3), 17382246 (1) (see all 9)
    polyinosinic-polycytidylic acid 54.9 5 19578865 (1), 18571707 (1), 16818783 (1), 17395700 (1)



    Find genes that share compounds with TLR9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLR9 gene (2 alternative transcripts): 
    NM_017442.3  NM_138688.1  

    Unigene Cluster for TLR9:

    Toll-like receptor 9
    Hs.87968  [show with all ESTs]
    Unigene Representative Sequence: NM_017442
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360658(uc003dda.2) ENST00000597542
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTLR9 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TLR9 (NM_017442)
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    Additional mRNA sequence: 

    AB045180.1 AB445673.1 AF245704.1 AF246972.1 AF259262.1 AF259263.1 AY359085.1 BC032713.1 

    2 DOTS entries:

    DT.86821044  DT.95264846 

    Selected AceView cDNA sequences (see all 543):

    CA425086 AW769111 CD367730 CR623453 AA580444 BQ109541 CN479237 AA670201 
    CR599346 CR611569 AI494258 CR601320 AI591017 AW248880 CR608092 BM468857 
    AA922813 AB045180 CR602270 BQ890079 BG393052 BM907591 CB270332 BM927986 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLR9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TLR9 Expression
    About this image


    TLR9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TLR9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLR9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.87968

    UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96
    Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in
    plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also
    detected in lung and liver

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR9 (see all 11): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TLR9 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr91 , 5 toll-like receptor 91, 5 77.72(n)1
    75.56(a)1
      9 (57.46 cM)5
    818971  NM_031178.21  NP_112455.21 
     1062225985 
    chicken
    (Gallus gallus)
    Aves TLR216
    Gallus gallus Toll-like receptor 21 (TLR21), mRNA....
    26(a)
    many ↔ many
    11(342413-345901)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    23(a)
    many ↔ many
    2(122504100-122506901)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004943871 toll-like receptor 7-like 45.66(n)
    37.37(a)
      100494387  XM_002936487.2  XP_002936533.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tlr91 toll-like receptor 9 48.88(n)
    40.73(a)
      403128  NM_001130594.1  NP_001124066.1 


    ENSEMBL Gene Tree for TLR9 (if available)
    TreeFam Gene Tree for TLR9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLR9 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR52  TLR102  TLR42  TLR82  
    TLR62  TLR32  TLR22  
    2 SIMAP similar genes for TLR9 using alignment to 7 protein entries:     TLR9_HUMAN (see all proteins):
    TLR8    TLR7

    Find genes that share paralogs with TLR9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLR9 (see all 445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360784
    A colorectal cancer sample4--see VAR_0360782 T M mis40--------
    VAR_0360774
    A colorectal cancer sample4--see VAR_0360772 R H mis40--------
    rs1416389371,2
    C--52254635(+) TCACCC/TCTCCA 1 -- int10--------
    rs1462224141,2
    --52254656(+) AATTCA/GTTCTA 1 -- int10--------
    rs1825197431,2
    --52254710(+) CTTTGC/TTGAGC 1 -- int10--------
    rs57438491,2
    C,F,H--52254716(-) TCTGGC/TGCTCA 1 -- int114Minor allele frequency- T:0.05NA EU NS EA CSA WA 1292
    rs754318071,2
    F--52254740(+) TGCAGC/TTTCTC 1 -- int11Minor allele frequency- T:0.50NA 4
    rs1401229221,2
    --52254830(+) GTCTGC/TCAGGT 1 -- int10--------
    rs1437662321,2
    --52254920(+) CCAAGA/GCCACA 1 -- int10--------
    rs1131361371,2
    C--52255103(+) GCCTTG/CGGTAG 1 -- ut311Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for TLR9 (52255096 - 52273183 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TLR9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508926CNV Insertion20534489
    nsv834695CNV Loss17160897
    nsv460537CNV Loss19166990
    nsv876789CNV Loss21882294
    nsv508218CNV Loss20534489
    nsv470572CNV Loss18288195
    nsv834694CNV Gain17160897
    nsv482084CNV Gain20164927
    dgv5136n71CNV Gain21882294
    nsv519445CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): TLR9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR9
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605474    OMIM disorders: --

    11 diseases for TLR9:    
    About MalaCards
    meningococcal meningitis    ocular toxoplasmosis    irak-4 deficiency    systemic lupus erythematosus, association with
    granulomatosis with polyangiitis    crimean-congo hemorrhagic fever    toxoplasmosis    common variable immune deficiency
    lupus nephritis    hemorrhagic fever    malaria

    7 diseases from the University of Copenhagen DISEASES database for TLR9:
    Lupus erythematosus     Connective tissue disease     Malaria     Hypersensitivity reaction type I disease
    Cancer     Asthma     Common variable immunodeficiency

    Find genes that share disorders with TLR9           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TLR9 gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lupus erythematosus systemic 58.4 27 19130296 (2), 17516623 (2), 18613842 (1), 18262306 (1) (see all 16)
    autoimmune diseases 50.5 15 17961163 (2), 18513998 (2), 19587007 (2), 18613842 (1) (see all 11)
    autoimmunity 42 1 12740574 (1)
    inflammation 40.8 9 14632662 (1), 19129482 (1), 15843514 (1), 17145922 (1) (see all 9)
    virus infection 38.3 8 15592841 (2), 17360657 (1), 19129482 (1), 19644151 (1) (see all 7)
    infectious disease 38 5 16365416 (1), 17854429 (1), 17330401 (1), 18457466 (1) (see all 5)
    allergy 36.7 4 16164440 (1), 18071654 (1), 19630573 (1)
    necrosis 34.8 11 16510559 (1), 14688201 (1), 15507621 (1), 18922969 (1) (see all 10)
    tumors 32.7 94 19319670 (6), 15631627 (5), 17675511 (4), 17440926 (4) (see all 37)
    asthma 30.4 13 18312481 (2), 19096003 (2), 19034349 (2), 16164440 (1) (see all 6)

    Genetic Association Database (GAD): TLR9
    Human Genome Epidemiology (HuGE) Navigator: TLR9 (111 documents)

    Export disorders for TLR9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLR9 gene, integrated from 10 sources (see all 816):
    (articles sorted by number of sources associating them with TLR9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 9 Du X.... Beutler B. (Eur. Cytokine Netw. 2000)
    2. TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression. (PubMed id 19284650)1, 4, 9 Campino S....Kwiatkowski D.P. (Malar. J. 2009)
    3. Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. (PubMed id 19130296)1, 4, 9 Xu C.J....Ye D.Q. (Mol. Biol. Rep. 2009)
    4. Common human Toll-like receptor 9 polymorphisms and haplotypes: association with atopy and functional relevance. (PubMed id 16164440)1, 4, 9 BerghAPfer B....Hackstein H. (Clin. Exp. Allergy 2005)
    5. TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort. (PubMed id 17914947)1, 4, 9 Hong J....Krissansen G.W. (J. Gastroenterol. Hepatol. 2007)
    6. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. (PubMed id 17344245)1, 4, 9 Tao K....Yasutomo K. (Ann. Rheum. Dis. 2007)
    7. Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity. (PubMed id 16849519)1, 7, 9 Merrell M.A....Selander K.S. (Mol. Cancer Res. 2006)
    8. Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus. (PubMed id 16575840)1, 4, 9 De Jager P.L....Rioux J.D. (Arthritis Rheum. 2006)
    9. Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. (PubMed id 16125159)1, 4, 9 Hamann L....Schumann R.R. ( international journal of clinical chemistry 2006)
    10. Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. (PubMed id 15878652)1, 4, 9 Kikuchi K....Gershwin M.E. (J. Autoimmun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54106 HGNC: 15633 AceView: PTK9LandTLR9 Ensembl:ENSG00000239732 euGenes: HUgn54106
    ECgene: TLR9 Kegg: 54106 H-InvDB: TLR9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLR9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLR9 gene:
    Search GeneIP for patents involving TLR9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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