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TLR9 Gene

protein-coding GIFtS: 62

GC03M052230

toll-like receptor 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD289 ^¹, ²

Descriptions
CD289 antigen ^³
toll-like receptor 9 ^²

External Ids
HGNC: 15633¹
Entrez Gene: 54106²
UniProtKB: Q9NR96³
Ensembl: ENSG00000173366⁷

Search outside databases for aliases for TLR9 gene

Previous GC identifers: GC03M051347 GC03M051507 GC03M052111 GC03M052213

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TLR9:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a

fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly

conserved from Drosophila to humans and share structural and functional similarities. They

recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents,

and mediate the production of cytokines necessary for the development of effective immunity. The

various TLRs exhibit different patterns of expression. This gene is preferentially expressed in

immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes.

Studies in mice and human indicate that this receptor mediates cellular response to unmethylated

CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq]

UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96

Function: Participates in the innate immune response to microbial agents. Detects the unmethylated

cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6,

leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

Gene Wiki entry for TLR9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TLR9 gene

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.3

TLR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M052230: (about GC identifiers)

Start:	52,230,138 bp from pter
End:	52,235,219 bp from pter
Size:	5,082 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96 (See protein sequence)

Recommended Name: Toll-like receptor 9 precursor

Size: 1032 amino acids; 115860 Da

Subunit: Binds MYD88 via their respective TIR domains (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)

Secondary accessions: B3Y661 Q6UVZ2 Q9HD68 Q9HD69 Q9HD70 Q9NYC2 Q9NYC3

Alternative splicing: 5 isoforms: Q9NR96-1 Q9NR96-2 Q9NR96-3 Q9NR96-4 Q9NR96-5 (Additional isoforms seem to exist)

REFSEQ proteins: NP_059138.1

ENSEMBL proteins:

ENSP00000353874

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TLR9)
	Human Recombinant Proteins from Abnova (TLR9)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	11130078
GO:0005886	plasma membrane	IEA	--
GO:0010008	endosome membrane	EXP	14625308 14751759 15207506 16024789
GO:0016021	integral to membrane	IEA	--

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Antibodies for TLR9:

	Invitrogen Antibodies for TLR9
	Millipore Mono- and Polyclonal Antibodies for the study of TLR9
	Sigma-Aldrich Antibodies for TLR9
	R&D Systems Antibodies for TLR9
	Antibodies from Abcam (TLR9), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TLR9)
	Novus Biologicals Antibodies for TLR9

Assays for TLR9:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9NR96

ProtoNet protein and cluster: Q9NR96

1 Blocks protein family: IPB000157 TIR domain

UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96

Similarity: Belongs to the Toll-like receptor family

Similarity: Contains 26 LRR (leucine-rich) repeats

Similarity: Contains 1 TIR domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TLR9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TLR9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138688

Applied Biosystems Silencer® siRNAs for TLR9

Sigma-Aldrich siRNA and siRNA Panels for TLR9

Sigma-Aldrich shRNA for TLR9

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TLR9
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_017442
Myc/DDK tagged cDNA clone in CMV expression vector: NM_017442
untagged cDNA clones in CMV expression vector (see all 2): NM_017442

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_017442

UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96

Function: Participates in the innate immune response to microbial agents. Detects the unmethylated

cytidine-phosphate-guanosine (CpG) motifs present in bacterial DNA. Acts via MYD88 and TRAF6,

leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

5 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Tlr9):

hematopoietic system

homeostasis/metabolism

immune system

life span-post-weaning/aging

renal/urinary system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	IEA	--
GO:0005515	protein binding	IPI	17474147
GO:0035197	siRNA binding	IMP	15723075

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for TLR9 (Your Favorite Gene powered by Ingenuity)

Dendritic Cell Maturation
Toll-like Receptor Signaling
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
NF-&kappa
TREM1 Signaling

GeneDecks TLR9 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TLR9

5/98 Interacting proteins for TLR9 (ENSP00000353874³ Q9NR96¹) via UniProtKB, MINT, and/or STRING (see all 98 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCK1	P16333¹	EBI-1762509, EBI-389883
IRAK1	ENSP00000358997³	STRING (score=.996)
IL6	ENSP00000258743³	STRING (score=.967)
IRF7	ENSP00000329411³	STRING (score=.967)
IFNG	ENSP00000229135³	STRING (score=.965)

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006954	inflammatory response	IEA	--
GO:0007165	signal transduction	IEA	--
GO:0007249	I-kappaB kinase/NF-kappaB cascade	EXP	15276183
GO:0009615	response to virus	IEA	--
GO:0042742	defense response to bacterium	NAS	11130078

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TLR9
10/21 Novoseek chemical compound relationships for TLR9 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
loxoribine	81.69	1	15778362 (1)
resiquimod	80.16	5	19183807 (1), 15827165 (1), 15778362 (1)
poly(i-c)	67.36	1	16299289 (1)
phosphorothioate	65.96	19	18342006 (3), 15634876 (1), 15879106 (1), 16421948 (1)
flagellin	61.58	10	17586660 (2), 18256754 (1), 18571707 (1), 18819410 (1) (see all 7)
lipoteichoic acid	61.41	2	18571707 (1), 16175622 (1)
phosphodiester	55.55	25	16421948 (5), 18342006 (3), 18656540 (3), 17382246 (1) (see all 6)
peptidoglycan	48.73	7	19127075 (1), 14996826 (1), 16818783 (1), 16133988 (1) (see all 6)
hemozoin	35.27	5	17261807 (3), 15950450 (1)
oligonucleotide	32.95	16	18922969 (2), 16818518 (2), 16864658 (1), 17487373 (1) (see all 9)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TLR9)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TLR9)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138688

Sigma-Aldrich siRNA and siRNA Panels for TLR9

Sigma-Aldrich shRNA for TLR9

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_017442

REFSEQ mRNAs for TLR9 gene:

NM_017442.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_017442

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017442
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_017442
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_017442

Additional cDNA sequence:

AB045180.1 AB445673.1 AF245704.1 AF246972.1 AF259262.1 AF259263.1 AY359085.1 BC032713.1

2 DOTS entries:

DT.86821044 DT.95264846

24/543 AceView cDNA sequences (see all 543 ):

F09954 CB270332 BM456154 AL136773 BQ680020 CR533520 CR590947 BM553855

CD367456 BM808377 CA425086 AI090271 CA424627 AF246974 AA832220 CB529943

BQ678080 AB045180 CR596947 CR603095 CR607625 CR606881 AF245704 CD624013

highest scoring ESTs for TLR9:

AB045180 AF245704 AF259262 AL558896 AL560131 BC032713 BE245817 BM459189 CD628235 CD628237

Unigene Cluster for TLR9:

Toll-like receptor 9

Hs.87968 [show with all ESTs]

Unigene Representative Sequence: NM_017442

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TLR9

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d
SP1:					-
SP2:																					-		-				-
SP3:																					-		-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TLR9

1 Ensembl transcript including schematic representation:

ENST00000360658

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TLR9 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TLR9

¹ / ² / ³

2 probe-sets matching TLR9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
223903_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB045180	0.80	0.88	0.84	1
223903_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.87968
UniProtKB/Swiss-Prot: TLR9_HUMAN, Q9NR96
Tissue specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes,
especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+
immature dendritic cells. Also detected in lung and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TLR9 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TLR9¹	--	toll-like receptor 9	85.28(n) 81.91(a)	403502 NM_001002998.1 NP_001002998.1
chimpanzee (Pan troglodytes)	TLR9¹	--	toll-like receptor 9	99.22(n) 99.13(a)	470827 XM_001171324.1 XP_001171324.1
cow (Bos taurus)	TLR9¹	--	toll-like receptor 9	83.74(n) 80.22(a)	282602 NM_183081.1 NP_898904.1
mouse (Mus musculus)	Tlr9^{1, 5}	9⁵	toll-like receptor 9^{1, 5}	77.96(n)¹ 75.75(a)¹	81897¹ NM_031178.1¹ NP_112455.1¹ AA162495⁵ AA197442⁵ (see all 13)
zebrafish (Danio rerio)	tlr9¹	--	toll-like receptor 9	48.57(n) 40.7(a)	403128 XM_685911.3 XP_691003.3

About this table Species with no ortholog for TLR9

ENSEMBL Gene Tree for TLR9

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TLR9 gene

TLR7² TLR3² TLR5² TLR8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/58 NCBI SNPs in TLR9 are shown (see all 58 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 52)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs187084^1,2	A,C,F,H	52236071(-)	`gccctT/Caagaa`	1	--	ng3¹		11	EU EA WA NA	926
	rs352144^1,2	C,F,H	52236508(-)	`GGCTCA/CGGGCA`	1	--	ng3¹		11	EA NA EU WA	658
	rs5743845^1,2	C,F,H	52230784(-)	`TGGGCG/AAGATG`	1	Q/R	mis¹ ese³		7	NA EU EA WA	490
	rs5743839^1,2	C,F,H	52235444(-)	`AGCATG/AGTGGA`	1	--	ng3¹		7	NA EU EA WA	498
	rs5743846^1,2	C,F,H	52230728(-)	`AGAGCG/ACAGTG`	1	T/A	mis¹ ese³		11	NA EU EA WA	908
	rs5743842^1,2	F,H	52233359(-)	`TCTGCC/TGCAGC`	1	R/C	mis¹ ese³		7	NA EU EA WA	502
--	rs5743838^1,2	C,F	52235638(-)	`GGAGGG/AGTCTG`	1	--	ng3¹		3	NA EU	94
	rs5743848^1,2	C,H	52230255(-)	`ATCCTG/CCACGG`	1	--	ut3¹ ese³		7	NA EU EA WA	494
	rs5743847^1,2	F,H	52230270(-)	`TAGCCG/ATGAGC`	1	--	ut3¹ ese³		7	NA EU EA WA	514
	rs5743849^1,2	F,H	52229756(-)	`TCTGGC/TGCTCA`	1	--	ng5¹		7	NA EU EA WA	492

About this table

HapMap Linkage Disequilibrium images for TLR9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605474

10/44 Novoseek disease relationships for TLR9 gene (see all 44 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lupus erythematosus systemic	54.85	20	17516623 (2), 18613842 (1), 18262306 (1), 18373699 (1) (see all 13)
autoimmune diseases	45.47	12	17961163 (2), 18513998 (2), 18613842 (1), 18208876 (1) (see all 9)
autoimmunity	44.77	1	12740574 (1)
infectious disease	39.96	5	16365416 (1), 17854429 (1), 17330401 (1), 18457466 (1) (see all 5)
virus infection	37.06	7	15592841 (2), 17360657 (1), 19129482 (1), 17085599 (1) (see all 6)
inflammation	36.34	7	14632662 (1), 19129482 (1), 15843514 (1), 17145922 (1) (see all 7)
necrosis	33.75	10	16510559 (1), 14688201 (1), 15507621 (1), 18922969 (1) (see all 9)
allergy	33.26	2	16164440 (1), 18071654 (1)
herpes simplex	31.56	6	17085599 (2), 19025601 (1), 18082566 (1), 11927638 (1) (see all 5)
asthma allergic	29.42	1	14987294 (1)

About this table

Human Gene Mutation Database: TLR9
Genetic Association Database: TLR9
Human Genome Epidemiology Navigator: TLR9 (46 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/466 PubMed articles for TLR9 gene (see all 466 ):

Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)^{1, 2, 3, 4} Du X.... Beutler B. (2000)
Common human Toll-like receptor 9 polymorphisms and haplotypes: association with atopy and functional relevance. (PubMed id 16164440)^{1, 3, 6} Berghofer B....Hackstein H. (2005)
Toll-like receptor (TLR)-9 promotor polymorphisms and atherosclerosis. (PubMed id 16125159)^{1, 3, 6} Hamann L....Schumann R.R. (2006)
Genetic polymorphisms of toll-like receptor 9 influence the immune response to CpG and contribute to hyper-IgM in primary biliary cirrhosis. (PubMed id 15878652)^{1, 3, 6} Kikuchi K....Gershwin M.E. (2005)
Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. (PubMed id 16371473)^{1, 3, 6} Mockenhaupt F.P....Schumann R.R. (2006)
Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus. (PubMed id 15730519)^{1, 3, 6} Hur J.W....Bae S.C. (2005)
An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. (PubMed id 14987294)^{1, 3, 6} Noguchi E....Arinami T. (2004)
Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. (PubMed id 12573264)^{1, 3, 6} Lazarus R....Weiss S.T. (2003)
Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)^{3, 4} Nakajima T....Kimura A. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54106	HGNC: 15633	AceView: PTK9LandTLR9	Ensembl:ENSG00000173366	euGenes: HUgn54106
ECgene: TLR9	H-InvDB: TLR9

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TLR9
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TLR9:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TLR9-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TLR9		Antibodies for TLR9
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TLR9		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TLR9)
	Antibodies (TLR9)
	Chimera RNAi (TLR9)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TLR9)
	Antibodies (TLR9)

Search OriGene for TLR9

Search Tocris compounds for TLR9

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TLR9

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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TLR9 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for TLR9

Summaries
for TLR9

Genomic Location
for TLR9

Proteins
for TLR9

Protein Domains/
Families
for TLR9

Gene Function
for TLR9

Pathways & Interactions
for TLR9

Drugs & Compounds
for TLR9

Transcripts
for TLR9

Expression
for TLR9

Orthologs
for TLR9

Paralogs
for TLR9

SNPs/Variants
for TLR9

Disorders & Mutations
for TLR9

Medical News
for TLR9

Publications
for TLR9

Search for TLR9

Genome Databases showing TLR9

Other Databases showing TLR9

Specialized Databases showing TLR9

Licensable Technologies
for TLR9

Services
for TLR9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TLR9 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor TLR9

Summariesfor TLR9

Genomic Locationfor TLR9

Proteinsfor TLR9

Protein Domains/Familiesfor TLR9

Gene Functionfor TLR9

Pathways & Interactionsfor TLR9

Drugs & Compoundsfor TLR9

Transcriptsfor TLR9

Expression for TLR9

Orthologsfor TLR9

Paralogsfor TLR9

SNPs/Variantsfor TLR9

Disorders & Mutationsfor TLR9

Medical Newsfor TLR9

Publicationsfor TLR9

Search for TLR9

Genome Databases showing TLR9

Other Databases showing TLR9

Specialized Databases showing TLR9

Licensable Technologiesfor TLR9

Servicesfor TLR9

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TLR9

Summaries
for TLR9

Genomic Location
for TLR9

Proteins
for TLR9

Protein Domains/
Families
for TLR9

Gene Function
for TLR9

Pathways & Interactions
for TLR9

Drugs & Compounds
for TLR9

Transcripts
for TLR9

Expression
for TLR9

Orthologs
for TLR9

Paralogs
for TLR9

SNPs/Variants
for TLR9

Disorders & Mutations
for TLR9

Medical News
for TLR9

Publications
for TLR9

Licensable Technologies
for TLR9

Services
for TLR9