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Aliases for TLR8 Gene

Aliases for TLR8 Gene

  • Toll Like Receptor 8 2 3
  • Toll-Like Receptor 8 2 5
  • CD288 Antigen 4
  • CD288 3

External Ids for TLR8 Gene

Previous GeneCards Identifiers for TLR8 Gene

  • GC0XP012117
  • GC0XP011690
  • GC0XP012221
  • GC0XP012286
  • GC0XP012684
  • GC0XP012834
  • GC0XP010691

Summaries for TLR8 Gene

Entrez Gene Summary for TLR8 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR8 Gene

TLR8 (Toll Like Receptor 8) is a Protein Coding gene. Diseases associated with TLR8 include Crimean-Congo Hemorrhagic Fever and Viral Infectious Disease. Among its related pathways are p53 Pathway (RnD) and Th17 Differentiation Pathway. GO annotations related to this gene include RNA binding and drug binding. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR8 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Wiki entry for TLR8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR8 Gene

Genomics for TLR8 Gene

Regulatory Elements for TLR8 Gene

Enhancers for TLR8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TLR8 on UCSC Golden Path with GeneCards custom track

Promoters for TLR8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLR8 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLR8 Gene

Chromosome:
X
Start:
12,906,620 bp from pter
End:
12,923,169 bp from pter
Size:
16,550 bases
Orientation:
Plus strand

Genomic View for TLR8 Gene

Genes around TLR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR8 Gene

Proteins for TLR8 Gene

  • Protein details for TLR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR97-TLR8_HUMAN
    Recommended name:
    Toll-like receptor 8
    Protein Accession:
    Q9NR97
    Secondary Accessions:
    • B3Y654
    • D1CS70
    • D1CS76
    • Q495P4
    • Q6UXL6
    • Q9NYG9

    Protein attributes for TLR8 Gene

    Size:
    1041 amino acids
    Molecular mass:
    119828 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Homodimer. Interacts with BTK.

    Three dimensional structures from OCA and Proteopedia for TLR8 Gene

    Alternative splice isoforms for TLR8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR8 Gene

Proteomics data for TLR8 Gene at MOPED

Post-translational modifications for TLR8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLR8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLR8 (TLR8)
  • Abcam antibodies for TLR8

No data available for DME Specific Peptides for TLR8 Gene

Domains & Families for TLR8 Gene

Gene Families for TLR8 Gene

Suggested Antigen Peptide Sequences for TLR8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR97

UniProtKB/Swiss-Prot:

TLR8_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the Toll-like receptor family.
  • Contains 23 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 23 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR8: view

Function for TLR8 Gene

Molecular function for TLR8 Gene

UniProtKB/Swiss-Prot Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Ontology (GO) - Molecular Function for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with TLR8: view
genes like me logo Genes that share phenotypes with TLR8: view

Animal Models for TLR8 Gene

MGI Knock Outs for TLR8:

Animal Model Products

  • Taconic Biosciences Mouse Models for TLR8

miRNA for TLR8 Gene

miRTarBase miRNAs that target TLR8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR8 Gene

Localization for TLR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR8 Gene COMPARTMENTS Subcellular localization image for TLR8 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
vacuole 5
golgi apparatus 4
plasma membrane 4
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TLR8 Gene

Pathways & Interactions for TLR8 Gene

genes like me logo Genes that share pathways with TLR8: view

Gene Ontology (GO) - Biological Process for TLR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0002224 toll-like receptor signaling pathway IEA,TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
GO:0006954 inflammatory response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 12032557
genes like me logo Genes that share ontologies with TLR8: view

No data available for SIGNOR curated interactions for TLR8 Gene

Drugs & Compounds for TLR8 Gene

(5) Drugs for TLR8 Gene - From: DrugBank, DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imiquimod Approved, Investigational Pharma Agonist, agonist, Target TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist 132
Resiquimod Pharma agonist Toll-like receptor 7 (TLR7) agonist 0
CPG 52364 Pharma antagonist Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
VTX-1463 Pharma 0
VTX-2337 Pharma immunostimulator immunostimulator 0

(3) Additional Compounds for TLR8 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
R848
Agonist
genes like me logo Genes that share compounds with TLR8: view

Transcripts for TLR8 Gene

Unigene Clusters for TLR8 Gene

Toll-like receptor 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR8 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: - -
SP2: - - -
SP3:

Relevant External Links for TLR8 Gene

GeneLoc Exon Structure for
TLR8
ECgene alternative splicing isoforms for
TLR8

Expression for TLR8 Gene

mRNA expression in normal human tissues for TLR8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR8 Gene

This gene is overexpressed in Whole Blood (x43.3).

Protein differential expression in normal tissues from HIPED for TLR8 Gene

This gene is overexpressed in Monocytes (36.3) and Blymphocyte (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR8 Gene



SOURCE GeneReport for Unigene cluster for TLR8 Gene Hs.660543

mRNA Expression by UniProt/SwissProt for TLR8 Gene

Q9NR97-TLR8_HUMAN
Tissue specificity: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
genes like me logo Genes that share expression patterns with TLR8: view

Protein tissue co-expression partners for TLR8 Gene

- Elite partner

Primer Products

Orthologs for TLR8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLR8 35
  • 80.71 (n)
  • 74.93 (a)
dog
(Canis familiaris)
Mammalia TLR8 35
  • 80.66 (n)
  • 77.51 (a)
TLR8 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr8 35
  • 76.73 (n)
  • 71.84 (a)
Tlr8 16
Tlr8 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLR8 35
  • 99.42 (n)
  • 99.62 (a)
TLR8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr8 35
  • 76.49 (n)
  • 72 (a)
oppossum
(Monodelphis domestica)
Mammalia TLR8 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495962 35
  • 58.96 (n)
  • 52.4 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332583 35
  • 51.7 (n)
  • 45.32 (a)
TLR8 (3 of 3) 36
  • 43 (a)
OneToMany
tlr8a 36
  • 42 (a)
OneToMany
tlr8b 36
  • 40 (a)
OneToMany
Species with no ortholog for TLR8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR8 Gene

ENSEMBL:
Gene Tree for TLR8 (if available)
TreeFam:
Gene Tree for TLR8 (if available)

Paralogs for TLR8 Gene

Paralogs for TLR8 Gene

(2) SIMAP similar genes for TLR8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TLR8: view

Variants for TLR8 Gene

Sequence variations from dbSNP and Humsavar for TLR8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_024667 -
VAR_052363 -

Variation tolerance for TLR8 Gene

Residual Variation Intolerance Score: 20.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLR8 Gene

Human Gene Mutation Database (HGMD)
TLR8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLR8 Gene

Disorders for TLR8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TLR8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
crimean-congo hemorrhagic fever
  • chf congo virus
viral infectious disease
  • arbovirus infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search TLR8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLR8

Genetic Association Database (GAD)
TLR8
Human Genome Epidemiology (HuGE) Navigator
TLR8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLR8
genes like me logo Genes that share disorders with TLR8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR8 Gene

Publications for TLR8 Gene

  1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X. … Beutler B. (Eur. Cytokine Netw. 2000) 2 3 4 23 67
  2. A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition. (PMID: 20004021) Liu J. … Chuang T.H. (Mol. Immunol. 2010) 3 23
  3. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. (PMID: 20237413) Cherfils-Vicini J. … Cremer I. (J. Clin. Invest. 2010) 3 23
  4. Toll-like receptor 8 polymorphism and coronary artery disease. (PMID: 18985439) Chen Z. … Tang C. (Mol. Biol. Rep. 2009) 3 23
  5. Expression and function of toll-like receptor 8 and Tollip in colonic epithelial cells from patients with inflammatory bowel disease. (PMID: 18985539) Steenholdt C. … Brynskov J. (Scand. J. Gastroenterol. 2009) 3 23

Products for TLR8 Gene

Sources for TLR8 Gene

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