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TLR8 Gene

protein-coding   GIFtS: 67
GCID: GC0XP012924

Toll-Like Receptor 8

  See TLR8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Toll-Like Receptor 81 2
CD2882
CD288 Antigen3

External Ids:    HGNC: 156321   Entrez Gene: 513112   Ensembl: ENSG000001019167   OMIM: 3003665   UniProtKB: Q9NR973   

Export aliases for TLR8 gene to outside databases

Previous GC identifers: GC0XP012117 GC0XP011690 GC0XP012221 GC0XP012286 GC0XP012684 GC0XP012834 GC0XP010691


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLR8 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly
expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on
chromosome X. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLR8 Gene:
TLR8 (toll-like receptor 8) is a protein-coding gene. Diseases associated with TLR8 include crimean-congo hemorrhagic fever, and hemorrhagic fever. GO annotations related to this gene include double-stranded RNA binding and RNA binding. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6,
leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

Gene Wiki entry for TLR8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLR8 gene promoter:
         CHOP-10   Sox5   FAC1   STAT1   IRF-7A   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR8 promoter sequence
   Search Chromatin IP Primers for TLR8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22

TLR8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR8 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP012924:  view genomic region     (about GC identifiers)

Start:
12,924,739 bp from pter      End:
12,941,288 bp from pter
Size:
16,550 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97 (See protein sequence)
Recommended Name: Toll-like receptor 8 precursor  
Size: 1041 amino acids; 119828 Da
Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Homodimer.
Interacts with BTK
6 PDB 3D structures from and Proteopedia for TLR8:
3W3G (3D)        3W3J (3D)        3W3K (3D)        3W3L (3D)        3W3M (3D)        3W3N (3D)    
Secondary accessions: B3Y654 D1CS70 D1CS76 Q495P4 Q6UXL6 Q9NYG9
Alternative splicing: 2 isoforms:  Q9NR97-1   Q9NR97-2   

Explore the universe of human proteins at neXtProt for TLR8: NX_Q9NR97

Explore proteomics data for TLR8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn29, Asn42, Asn80, Asn88, Asn115, Asn160, Asn247, Asn285, Asn293, Asn358,
                                 Asn362, Asn395, Asn416, Asn443, Asn511, Asn546, Asn582, Asn590, Asn640, Asn680 (see all 21)
  • Modification sites at PhosphoSitePlus

  • See TLR8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_619542.1  
    ENSEMBL proteins: 
     ENSP00000218032   ENSP00000312082  
    Reactome Protein details: Q9NR97

    TLR8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TLR8

     
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    TLR8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TLR8
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    TLR8 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR8
    Toll-like receptor family

    5 InterPro protein domains:
     IPR027175 TLR8
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q9NR97

    ProtoNet protein and cluster: Q9NR97

    2 Blocks protein domains:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 23 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TLR8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR8_HUMAN, Q9NR97
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6,
    leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16123302
    GO:0003723RNA binding TAS16123302
    GO:0003725double-stranded RNA binding IDA16111635
    GO:0003727single-stranded RNA binding IDA14976262
    GO:0004872receptor activity NAS12032557
         
    Find genes that share ontologies with TLR8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TLR8:
     Decreased Salmonella enterica  

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tlr8):
     hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 

    Find genes that share phenotypes with TLR8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLR8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLR8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR8

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TLR8:
    hsa-miR-3662 hsa-miR-3120-3p hsa-miR-32* hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidTLR8 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TLR8

    Gene Editing
    Products:
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    Clone
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    Sino Biological Human cDNA Clone for TLR8
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    Addgene plasmids for TLR8 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLR8_HUMAN, Q9NR97: Membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    lysosome4
    vacuole4
    plasma membrane3
    nucleus2
    cytosol1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0016021integral component of membrane IC12032557
    GO:0036020endolysosome membrane TAS--

    Find genes that share ontologies with TLR8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLR8 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88 dependent cascade initiated on endosome0.69
    Toll Like Receptor 9 (TLR9) Cascade0.93
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    3NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    NOD-like Receptor Signaling Pathways0.58
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    4NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    5TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41


    Find genes that share SuperPaths with TLR8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TLR8 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLR8 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR8
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR8
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR8
        Immune response TLR signaling pathways

    2 BioSystems Pathways for TLR8
        Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway


    5 Reactome Pathways for TLR8
        Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Trafficking and processing of endosomal TLR
    MyD88 dependent cascade initiated on endosome


    1 Kegg Pathway  (Kegg details for TLR8):
        Toll-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR8: 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLR8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TLR8 (Q9NR973 ENSP000002180324) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    TLR7Q9NYK13, ENSP000003700344I2D: score=1 STRING: ENSP00000370034
    TLR9Q9NR963, ENSP000003538744I2D: score=1 STRING: ENSP00000353874
    MYD88Q998363, ENSP000003796254I2D: score=1 STRING: ENSP00000379625
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
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    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002282microglial cell activation involved in immune response IEA--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway ----
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    Find genes that share ontologies with TLR8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TLR8
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLR8

    1 DrugBank Compound for TLR8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Imiquimod-- 99011-02-6targetagonist15661881 14616353 18439678

    2 IUPHAR Ligands for TLR8 (TLR8)    About this table
    LigandTypeActionAffinityPubmed IDs
    imiquimod
    AgonistAgonist--
    R848
    AgonistAgonist11812998

    4 Novoseek inferred chemical compound relationships for TLR8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    resiquimod 92.4 1 14638493 (1)
    imidazoquinoline 89.2 7 17868034 (2), 18031250 (1), 18439678 (1), 17082568 (1) (see all 5)
    imiquimod 75.5 8 18439678 (2), 19017992 (1), 19164127 (1), 16728430 (1)
    poly(i-c) 59.7 1 14530316 (1)



    Find genes that share compounds with TLR8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLR8 gene (2 alternative transcripts): 
    NM_138636.5  NM_016610.2  

    Unigene Cluster for TLR8:

    Toll-like receptor 8
    Hs.660543  [show with all ESTs]
    Unigene Representative Sequence: NM_138636
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000218032(uc004cve.3 uc004cvd.3) ENST00000311912
    miRNA
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    hsa-miR-3662 hsa-miR-3120-3p hsa-miR-32* hsa-miR-4308
    SwitchGear 3'UTR luciferase reporter plasmidTLR8 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TLR8
      QuantiFast Probe-based Assays in human, mouse, rat TLR8

    Additional mRNA sequence: 

    AB445666.1 AF245703.1 AF246971.1 AK075117.1 AK297024.1 AK307562.1 AK314240.1 AY358296.1 
    BC101074.1 BC101075.2 BC101076.2 BC101077.1 

    2 DOTS entries:

    DT.109879  DT.91707993 

    Selected AceView cDNA sequences (see all 28):

    BX106790 AA922616 CR596887 BE857344 NM_016610 AA740964 AI424196 BQ448547 
    AY358296 AF245703 AI261982 AK075117 AL544223 NM_138636 AA568781 AF246971 
    CD365421 AA042875 AA707766 AI890649 C01399 AW872374 CA310384 AA042999 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TLR8    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
    SP1:              -           -               
    SP2:              -     -     -               
    SP3:                                          


    ECgene alternative splicing isoforms for TLR8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TLR8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTATATTAT
    TLR8 Expression
    About this image


    TLR8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    TLR8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLR8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660543

    UniProtKB/Swiss-Prot: TLR8_HUMAN, Q9NR97
    Tissue specificity: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+
    immature dendritic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR8: 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TLR8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr81 , 5 toll-like receptor 81, 5 76.73(n)1
    71.84(a)1
      X (78.29 cM)5
    1707441  NM_133212.21  NP_573475.21 
     1672426965 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    23(a)
    many ↔ many
    GL343329.1(715435-726610)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004959621 toll-like receptor 8-like 58.96(n)
    52.4(a)
      100495962  XM_004912345.1  XP_004912402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003325831 toll-like receptor 8-like 51.7(n)
    45.32(a)
      100332583  XM_002665908.3  XP_002665954.3 


    ENSEMBL Gene Tree for TLR8 (if available)
    TreeFam Gene Tree for TLR8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLR8 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR92  TLR52  TLR102  TLR42  
    TLR62  TLR32  TLR22  
    2 SIMAP similar genes for TLR8 using alignment to 3 protein entries:     TLR8_HUMAN (see all proteins):
    TLR7    TLR9

    Find genes that share paralogs with TLR8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TLR8 (see all 331)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs723601521,2
    C--12838253(+) CACAC-/ATAT  
            
    ATATA
    1 -- us2k10--------
    rs59354401,2
    C,A--12838254(+) ACACAC/TATATA 1 -- us2k1 tfbs31Minor allele frequency- T:0.00CSA 1
    rs59354411,2
    C--12838256(+) ACATAC/TATATA 1 -- us2k1 tfbs30--------
    rs59354421,2
    C,F,A--12838547(+) TCAAGC/TGATCC 1 -- us2k14Minor allele frequency- T:0.29NA WA 7
    rs59354431,2
    C,F,A--12838635(+) GACAAG/TGTTTT 1 -- us2k13Minor allele frequency- T:0.40NA WA 5
    rs1433987111,2
    --12838759(+) TTACTC/TTCTTT 1 -- us2k10--------
    rs1890393551,2
    C--12838822(+) CAGCCA/GAGGCC 1 -- us2k10--------
    rs57440401,2
    F--12838977(+) CCCACC/ACAAGC 1 -- us2k13Minor allele frequency- A:0.01NA EU 94
    rs57440411,2
    C,F,H--12838993(+) TTTGAC/TTGCTG 1 -- us2k112Minor allele frequency- T:0.01NA EU MN NS EA 920
    rs57440421,2
    C,F--12839074(+) TGCCAA/GTTTGG 1 -- us2k18Minor allele frequency- G:0.01NA EU MN 502

    HapMap Linkage Disequilibrium report for TLR8 (12924739 - 12941288 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TLR8: --
    Human Gene Mutation Database (HGMD): TLR8
    Locus Specific Mutation Databases (LSDB): TLR8

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR8
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300366    OMIM disorders: --

    2 diseases for TLR8:    
    About MalaCards
    crimean-congo hemorrhagic fever    hemorrhagic fever


    Find genes that share disorders with TLR8           About GenesLikeMe

    6 Novoseek inferred disease relationships for TLR8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 46 5 14530316 (1), 19644151 (1), 19164127 (1), 17964520 (1)
    inflammation 20.7 1 14530316 (1)
    influenza 1.34 1 16959331 (1)
    necrosis 0 2 19527497 (1), 17548497 (1)
    tumors 0 5 20237413 (3), 19527497 (1), 17548497 (1)
    cancer 0 4 18176600 (2), 19848448 (1), 17476348 (1)

    Genetic Association Database (GAD): TLR8
    Human Genome Epidemiology (HuGE) Navigator: TLR8 (28 documents)

    Export disorders for TLR8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLR8 gene, integrated from 10 sources (see all 203):
    (articles sorted by number of sources associating them with TLR8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 9 Du X.... Beutler B. (Eur. Cytokine Netw. 2000)
    2. Toll-like receptor 8 polymorphism and coronary artery disease. (PubMed id 18985439)1, 4, 9 Chen Z....Tang C. (Mol. Biol. Rep. 2009)
    3. A functional toll-like receptor 8 variant is associated with HIV disease restriction. (PubMed id 18605904)1, 4, 9 Oh D.Y....Schumann R.R. (J. Infect. Dis. 2008)
    4. Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis. (PubMed id 18927625)1, 4, 9 Davila S....Seielstad M. (PLoS Genet. 2008)
    5. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PubMed id 17964520)1, 4, 9 Cheng P.L....Lin T.M. (Transl Res 2007)
    6. Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands. (PubMed id 23520111)1, 2 Tanji H.... Shimizu T. (Science 2013)
    7. Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (Mol. Carcinog. 2011)
    8. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    9. Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients. (PubMed id 20595247)1, 4 Enevold C....Bendtzen K. (Mult. Scler. 2010)
    10. Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. (PubMed id 20227302)1, 4 Kastelijn E.A....van den Bosch J.M. (J. Heart Lung Transplant. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51311 HGNC: 15632 AceView: TLR8 Ensembl:ENSG00000101916 euGenes: HUgn51311
    ECgene: TLR8 Kegg: 51311 H-InvDB: TLR8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TLR8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TLR8 gene:
    Search GeneIP for patents involving TLR8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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