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TLR7 Gene

protein-coding   GIFtS: 67
GCID: GC0XP012885

Toll-Like Receptor 7

Microbiology & Infectious Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Toll-Like Receptor 71 2
TLR7-like2
Toll-Like Receptor 7-Like2

External Ids:    HGNC: 156311   Entrez Gene: 512842   Ensembl: ENSG000001966647   OMIM: 3003655   UniProtKB: Q9NYK13   

Export aliases for TLR7 gene to outside databases

Previous GC identifers: GC0XP012078 GC0XP011651 GC0XP012181 GC0XP012246 GC0XP012644 GC0XP012795 GC0XP010651


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLR7 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly
expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on
chromosome X. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLR7 Gene:
TLR7 (toll-like receptor 7) is a protein-coding gene. Diseases associated with TLR7 include anogenital venereal wart, and superficial basal cell carcinoma. GO annotations related to this gene include drug binding and single-stranded RNA binding. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a
nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B
activation, cytokine secretion and the inflammatory response (By similarity)

summary for TLR7 Gene:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR7 (TLR 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLR7 gene promoter:
         STAT1   AP-1   ATF-2   IRF-1   S8   FOXO4   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR7 promoter sequence
   Search Chromatin IP Primers for TLR7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.3

TLR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP012885:  view genomic region     (about GC identifiers)

Start:
12,885,202 bp from pter      End:
12,908,499 bp from pter
Size:
23,298 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1 (See protein sequence)
Recommended Name: Toll-like receptor 7 precursor  
Size: 1049 amino acids; 120922 Da
Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity)
Secondary accessions: D1CS69 Q9NR98

Explore the universe of human proteins at neXtProt for TLR7: NX_Q9NYK1

Explore proteomics data for TLR7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn66, Asn69, Asn167, Asn202, Asn215, Asn361, Asn413, Asn488, Asn523, Asn534,
                                 Asn590, Asn679, Asn720, Asn799
  • Modification sites at PhosphoSitePlus

  • See TLR7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057646.1  
    ENSEMBL proteins: 
     ENSP00000370034  
    Reactome Protein details: Q9NYK1

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    OriGene Protein Over-expression Lysate for TLR7
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    OriGene Custom Protein Services for TLR7
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    Novus Biologicals TLR7 Proteins
    Novus Biologicals TLR7 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR7

    TLR7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for TLR7

    TLR7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TLR7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLR7
    Cloud-Clone Corp. CLIAs for TLR7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR7
    Toll-like receptor family

    Selected InterPro protein domains (see all 7):
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR026880 TLR7
     IPR000157 TIR_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYK1

    ProtoNet protein and cluster: Q9NYK1

    3 Blocks protein domains:
    IPB000157 TIR domain
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 27 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    TLR7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR7_HUMAN, Q9NYK1
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a
    nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B
    activation, cytokine secretion and the inflammatory response (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA16111635
    GO:0003727single-stranded RNA binding ISS--
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--
         
    TLR7 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tlr7):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    TLR7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tlr7tm1Aki for TLR7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLR7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLR7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR7

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    Block miRNA regulation of human, mouse, rat TLR7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLR7 (see all 11):
    hsa-miR-577 hsa-miR-34b* hsa-miR-548o hsa-miR-520a-5p hsa-miR-942 hsa-miR-525-5p hsa-miR-1323 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTLR7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TLR7
    Predesigned siRNA for gene silencing in human, mouse, rat TLR7

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for TLR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLR7 (NM_016562)
    Sino Biological Human cDNA Clone for TLR7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLR7_HUMAN, Q9NYK1: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity).
    Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome. Note=Relocalizes from
    endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome4
    golgi apparatus4
    lysosome4
    plasma membrane4
    vacuole4
    extracellular2
    nucleus2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005737cytoplasm IDA19740627
    GO:0005764lysosome ISS--
    GO:0005768endosome ISS--
    GO:0005783endoplasmic reticulum ISS--

    TLR7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLR7 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88 dependent cascade initiated on endosome0.69
    Toll Like Receptor 9 (TLR9) Cascade0.93
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    3NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    NOD-like Receptor Signaling Pathways0.58
    4NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    5Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TLR7 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLR7 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR7
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR7
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR7
        Immune response TLR signaling pathways

    2 BioSystems Pathways for TLR7
        Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR7
        NF-kB (NFkB) Pathway

    5 Reactome Pathways for TLR7
        Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Trafficking and processing of endosomal TLR
    MyD88 dependent cascade initiated on endosome


    3 Kegg Pathways  (Kegg details for TLR7):
        Toll-like receptor signaling pathway
    Measles
    Influenza A


    TLR7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR7 (see all 7): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for TLR7 (Q9NYK13 ENSP000003700344) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TLR8Q9NR973, ENSP000002180324I2D: score=1 STRING: ENSP00000218032
    MYD88Q998363, ENSP000003796254I2D: score=2 STRING: ENSP00000379625
    CD14P085713I2D: score=2 
    UNC93B1Q9H1C43I2D: score=1 
    CNPY3ENSP000003619264STRING: ENSP00000361926
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002282microglial cell activation involved in immune response IEA--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway ----
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    TLR7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for TLR7
      Browse compounds at ApexBio 

    Compounds for TLR7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Pam2CSK4TLR2/6 agonist; induces TNF-alpha production[868247-72-7]
    ResiquimodToll-like receptor 7 (TLR7) agonist[144875-48-9]
    Pam3CSK4TLR1/2 agonist; induces cytokine production[112208-00-1]
    Poly(I:C)TLR3 agonist[42424-50-0]
    ImiquimodToll-like receptor 7 (TLR7) agonist[99011-02-6]

    2 DrugBank Compounds for TLR7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Imiquimod-- 99011-02-6targetagonist12527213 12470615 15072849 15068862 14616353 11752352
    Hydroxychloroquine-- 118-42-3targetantagonist14579285 11752352 18220957

    3 IUPHAR Ligands for TLR7 (TLR7)    About this table
    LigandTypeActionAffinityPubmed IDs
    imiquimod
    AgonistAgonist11812998
    R848
    AgonistAgonist11812998
    loxoribine
    AgonistAgonist14579267

    9 Novoseek inferred chemical compound relationships for TLR7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    resiquimod 91.7 6 14616338 (1), 15827165 (1), 14638493 (1), 15778362 (1)
    imidazoquinoline 88.7 4 19285861 (1), 18439678 (1), 18176600 (1)
    loxoribine 86.9 2 19685493 (1), 15778362 (1)
    imiquimod 81.9 22 18439678 (2), 19516264 (2), 16254370 (2), 20124101 (1) (see all 16)
    poly(i-c) 68.4 4 15804288 (2), 14530316 (1), 14530357 (1)
    lipoteichoic acid 60.8 6 19267841 (1), 18571707 (1)
    polyinosinic-polycytidylic acid 59.3 3 18571707 (1), 20181884 (1)
    chloroquine 53.7 3 12738885 (1), 15804288 (1)
    peptidoglycan 44.4 3 19843090 (1), 17332440 (1)



    TLR7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TLR7 gene: 
    NM_016562.3  

    Unigene Cluster for TLR7:

    Toll-like receptor 7
    Hs.659215  [show with all ESTs]
    Unigene Representative Sequence: AF240467
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380659(uc004cvc.3) ENST00000484204
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TLR7 (see all 11):
    hsa-miR-577 hsa-miR-34b* hsa-miR-548o hsa-miR-520a-5p hsa-miR-942 hsa-miR-525-5p hsa-miR-1323 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTLR7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TLR7
    Predesigned siRNA for gene silencing in human, mouse, rat TLR7
    Clone
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    OriGene ORF clones in mouse, rat for TLR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLR7 (NM_016562)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7
    Primer
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    OriGene qPCR primer pairs and template standards for TLR7
    OriGene qSTAR qPCR primer pairs in human, mouse for TLR7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLR7
      QuantiTect SYBR Green Assays in human, mouse, rat TLR7
      QuantiFast Probe-based Assays in human, mouse, rat TLR7

    Additional mRNA sequence: 

    AB445659.1 AF240467.1 AF245702.1 AJ812651.1 AK313858.1 AY358292.1 BC033651.1 

    2 DOTS entries:

    DT.108231  DT.40306487 

    24 AceView cDNA sequences:

    AF245702 AY358292 AA831880 BX114029 BC033651 CB215428 AI379982 AI829331 
    AF240467 NM_016562 N30597 BF510904 BG621854 BM454483 AA706705 AI307338 
    AA278673 CB047122 AA845644 CF529581 AA768459 N41840 AA315247 CB047121 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TLR7 expression in normal human tissues (normalized intensities)      TLR7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCTGAA
    TLR7 Expression
    About this image


    TLR7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
    TLR7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLR7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659215

    UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
    Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid
    pre-dendritic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR7 (see all 7): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TLR7 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr71 , 5 toll-like receptor 71, 5 83.16(n)1
    80.84(a)1
      X (78.31 cM)5
    1707431  NM_133211.31  NP_573474.11 
     1673049295 
    chicken
    (Gallus gallus)
    Aves TLR71 toll-like receptor 7 67.25(n)
    65.3(a)
      418638  NM_001011688.2  NP_001011688.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLR76
    toll-like receptor 7
    57(a)
    1 ↔ 1
    3(120031300-120038102)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tlr71 toll-like receptor 7 63.44(n)
    61.68(a)
      100151703  NM_001127411.1  NP_001120883.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tlr71 toll-like receptor 7 58.39(n)
    57.28(a)
      100534776  XM_003199261.2  XP_003199309.1 


    ENSEMBL Gene Tree for TLR7 (if available)
    TreeFam Gene Tree for TLR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLR7 gene
    ENSG000001733662  CD1802  TLR12  TLR92  TLR52  TLR102  TLR42  TLR82  
    TLR62  TLR32  TLR22  
    2 SIMAP similar genes for TLR7 using alignment to 3 protein entries:     TLR7_HUMAN (see all proteins):
    TLR8    TLR9

    TLR7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLR7 (see all 610)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919922581,2
    --12798811(+) GGCAAA/GTATCA 1 -- us2k10--------
    rs1847690761,2
    --12798826(+) AAATCC/TTATTG 1 -- us2k10--------
    rs1389884401,2
    C--12798914(+) CCCCAA/GTAACA 1 -- us2k10--------
    rs1875862711,2
    --12798964(+) AGGGTC/TCTGCC 1 -- us2k10--------
    rs28978271,2
    C,F,A,H--12798980(+) ACAGAT/CGGCAT 1 -- us2k19Minor allele frequency- C:0.87NS EA NA 562
    rs1441896991,2
    C--12799182(+) GCCAAC/TGCAGG 1 -- us2k10--------
    rs1913286101,2
    --12799195(+) CAGGCA/GGAGGG 1 -- us2k10--------
    rs1842725991,2
    --12799206(+) AGCCAA/GAGGGA 1 -- us2k10--------
    rs1891669681,2
    --12799208(+) CCAGAG/TGGAGG 1 -- us2k10--------
    rs1815769181,2
    --12799218(+) GCAGGC/TTCTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLR7 (12885202 - 12908499 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TLR7: --
    Human Gene Mutation Database (HGMD): TLR7
    Locus Specific Mutation Databases (LSDB): TLR7

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR7
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300365    OMIM disorders: --

    Selected diseases for TLR7 (see all 67):    About MalaCards
    anogenital venereal wart    superficial basal cell carcinoma    congenital heart block    lyme disease
    pandas    molluscum contagiosum    actinic keratosis    bronchiolitis obliterans
    bronchiolitis    biliary atresia    dengue hemorrhagic fever    otitis media
    basal cell carcinoma    keratosis    influenza    herpes simplex
    measles    hemorrhagic fever    b-cell chronic lymphocytic leukemia    vaginitis

    7 diseases from the University of Copenhagen DISEASES database for TLR7:
    Lupus erythematosus     Connective tissue disease     Influenza     Anogenital venereal wart
    Basal cell carcinoma     Actinic keratosis     Nephritis

    TLR7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for TLR7 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 60.7 12 14530316 (1), 17023556 (1), 17360657 (1), 19426550 (1) (see all 11)
    lupus erythematosus systemic 39.5 4 18613842 (1), 18373699 (1), 19714644 (1), 17979852 (1)
    necrosis 36.8 9 18765427 (1), 19267841 (1), 16960116 (1), 19251253 (1) (see all 6)
    inflammation 32.3 5 14530316 (1), 19019962 (1), 19129482 (1), 20232824 (1) (see all 5)
    hepatitis c 32.2 1 18021446 (1)
    tumors 26.6 18 20237413 (3), 17066089 (2), 18439103 (2), 17201162 (1) (see all 8)
    influenza 21.9 4 15593126 (2), 14976261 (1), 17082628 (1)
    infectious disease 20.9 2 16365416 (1), 19426145 (1)
    leukemia lymphocytic chronic 2.25 1 17066089 (1)
    herpes simplex 0 1 16423052 (1)

    Genetic Association Database (GAD): TLR7
    Human Genome Epidemiology (HuGE) Navigator: TLR7 (33 documents)

    Export disorders for TLR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLR7 gene, integrated from 10 sources (see all 367):
    (articles sorted by number of sources associating them with TLR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 9 Du X.... Beutler B. (Eur. Cytokine Netw. 2000)
    2. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. (PubMed id 18088248)1, 4, 9 Schott E....Berg T. (J. Viral Hepat. 2008)
    3. A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. (PubMed id 19114863)1, 4, 9 Oh D.Y....Schumann R.R. (AIDS 2009)
    4. Toll-like receptor polymorphisms and age-related macular degeneration. (PubMed id 18385087)1, 4, 9 Edwards A.O....Tosakulwong N. (amp 2008)
    5. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PubMed id 17964520)1, 4, 9 Cheng P.L....Lin T.M. (Transl Res 2007)
    6. Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (Mol. Carcinog. 2011)
    7. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    8. Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. (PubMed id 20227302)1, 4 Kastelijn E.A....van den Bosch J.M. (J. Heart Lung Transplant. 2010)
    9. Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population. (PubMed id 20525845)1, 4 GarcA-a-Ortiz H....Orozco L. (Ann. Rheum. Dis. 2010)
    10. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51284 HGNC: 15631 AceView: TLR7 Ensembl:ENSG00000196664 euGenes: HUgn51284
    ECgene: TLR7 Kegg: 51284 H-InvDB: TLR7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLR7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLR7 gene:
    Search GeneIP for patents involving TLR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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