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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLR7 Gene

protein-coding   GIFtS: 67
GCID: GC0XP012885

Toll-Like Receptor 7

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Toll-Like Receptor 71 2
TLR7-like2
Toll-Like Receptor 7-Like2

External Ids:    HGNC: 156311   Entrez Gene: 512842   Ensembl: ENSG000001966647   OMIM: 3003655   UniProtKB: Q9NYK13   

Export aliases for TLR7 gene to outside databases

Previous GC identifers: GC0XP012078 GC0XP011651 GC0XP012181 GC0XP012246 GC0XP012644 GC0XP012795 GC0XP010651


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR7 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly
expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on
chromosome X. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLR7 Gene: 
TLR7 (toll-like receptor 7) is a protein-coding gene. Diseases associated with TLR7 include anogenital venereal wart, and superficial basal cell carcinoma, and among its related super-pathways are Immune response TLR signaling pathways and Toll-like receptor signaling pathway. GO annotations related to this gene include drug binding and single-stranded RNA binding. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a
nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B
activation, cytokine secretion and the inflammatory response (By similarity)

summary for TLR7 Gene:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR7 (TLR 7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR7 gene promoter:
         STAT1   AP-1   ATF-2   IRF-1   S8   FOXO4   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLR7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.3

TLR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP012885:  view genomic region     (about GC identifiers)

Start:
12,885,202 bp from pter      End:
12,908,499 bp from pter
Size:
23,298 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1 (See protein sequence)
Recommended Name: Toll-like receptor 7 precursor  
Size: 1049 amino acids; 120922 Da
Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity).
Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome. Note=Relocalizes from
endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity)
Secondary accessions: D1CS69 Q9NR98

Explore the universe of human proteins at neXtProt for TLR7: NX_Q9NYK1

Explore proteomics data for TLR7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYK1

  • TLR7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLR7 Protein Expression
    REFSEQ proteins: NP_057646.1  
    ENSEMBL proteins: 
     ENSP00000370034  
    Reactome Protein details: Q9NYK1
    Human Recombinant Protein Products for TLR7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for TLR7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TLR7
    GenScript Custom Purified and Recombinant Proteins Services for TLR7
    Novus Biologicals TLR7 Proteins
    Novus Biologicals TLR7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR7 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005737cytoplasm IDA19740627
    GO:0005764lysosome ISS--
    GO:0005768endosome ISS--
    GO:0005783endoplasmic reticulum ISS--

    TLR7 for ontologies           About GeneDecksing



    TLR7 Antibody Products: 
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    Novus Biologicals TLR7 Antibodies
    Abcam antibodies for TLR7
    Cloud-Clone Corp. Antibodies for TLR7 
    ThermoFisher Antibody for TLR7
    LSBio Antibodies in human, mouse, rat for TLR7 

    Assay Products for TLR7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TLR7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLR7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLR7 
    Cloud-Clone Corp. CLIAs for TLR7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR7 
    Toll-like receptor family

    5/7 InterPro protein domains (see all 7):
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR026880 TLR7
     IPR000157 TIR_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYK1

    ProtoNet protein and cluster: Q9NYK1

    3 Blocks protein domains:
    IPB000157 TIR domain
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 27 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    TLR7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR7_HUMAN, Q9NYK1
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a
    nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B
    activation, cytokine secretion and the inflammatory response (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA16111635
    GO:0003727single-stranded RNA binding ISS--
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--
         
    TLR7 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tlr7):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    TLR7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tlr7tm1Aki for TLR7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLR7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLR7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLR7
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLR7 (see all 11):
    hsa-miR-577 hsa-miR-34b* hsa-miR-548o hsa-miR-520a-5p hsa-miR-942 hsa-miR-525-5p hsa-miR-1323 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTLR7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TLR7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TLR7
    Sirion Biotech Customized adenovirus for overexpression of TLR7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TLR7 (see all 7)
    OriGene ORF clones in mouse, rat for TLR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLR7 (NM_016562)
    Sino Biological Human cDNA Clone for TLR7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7
    Sirion Biotech Customized lentivirus for stable overexpression of TLR7 
                         Customized lentivirus expression plasmids for stable overexpression of TLR7 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TLR7
    Search LifeMap BioReagents cell lines for TLR7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLR7 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    3TRAF6 Mediated Induction of proinflammatory cytokines
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    Toll Like Receptor 9 (TLR9) Cascade0.89
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.92
    Toll-Like Receptors Cascades0.87
    MyD88 dependent cascade initiated on endosome0.92
    4Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52
    NOD-like Receptor Signaling Pathways0.59
    5NF-KappaB Family Pathway
    NF-KappaB Family Pathway0.72
    NF-KappaB (p50-p65) Pathway0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TLR7
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/6 R&D Systems Pathways for TLR7 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR7 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR7
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR7
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR7
        Immune response TLR signaling pathways

    1 BioSystems Pathway for TLR7
        Toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR7 
        NF-kB (NFkB) Pathway

    5/9        Reactome Pathways for TLR7 (see all 9)
        TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Toll-Like Receptors Cascades
    MyD88 dependent cascade initiated on endosome
    Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation


    3         Kegg Pathways  (Kegg details for TLR7):
        Toll-like receptor signaling pathway
    Measles
    Influenza A


    TLR7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for TLR7 (Q9NYK13 ENSP000003700344) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TLR8Q9NR973, ENSP000002180324I2D: score=1 STRING: ENSP00000218032
    MYD88Q998363, ENSP000003796254I2D: score=2 STRING: ENSP00000379625
    CD14P085713I2D: score=2 
    UNC93B1Q9H1C43I2D: score=1 
    CNPY3ENSP000003619264STRING: ENSP00000361926
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002282microglial cell activation involved in immune response IEA--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway ----
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----

    TLR7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TLR7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TLR7

    Compounds for TLR7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Pam2CSK4TLR2/6 agonist; induces TNF-alpha production[868247-72-7]
    ResiquimodToll-like receptor 7 (TLR7) agonist[144875-48-9]
    Pam3CSK4TLR1/2 agonist; induces cytokine production[112208-00-1]
    Poly(I:C)TLR3 agonist[42424-50-0]
    ImiquimodToll-like receptor 7 (TLR7) agonist[99011-02-6]

    2 DrugBank Compounds for TLR7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Imiquimod-- 99011-02-6targetagonist12527213 12470615 15072849 15068862 14616353 11752352
    Hydroxychloroquine-- 118-42-3targetantagonist14579285 11752352 18220957

    3 IUPHAR Ligands for TLR7 (TLR7)    About this table 
    LigandTypeActionAffinityPubmed IDs
    imiquimod
    AgonistAgonist11812998
    R848
    AgonistAgonist11812998
    loxoribine
    AgonistAgonist14579267

    9 Novoseek inferred chemical compound relationships for TLR7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    resiquimod 91.7 6 14616338 (1), 15827165 (1), 14638493 (1), 15778362 (1)
    imidazoquinoline 88.7 4 19285861 (1), 18439678 (1), 18176600 (1)
    loxoribine 86.9 2 19685493 (1), 15778362 (1)
    imiquimod 81.9 22 18439678 (2), 19516264 (2), 16254370 (2), 20124101 (1) (see all 16)
    poly(i-c) 68.4 4 15804288 (2), 14530316 (1), 14530357 (1)
    lipoteichoic acid 60.8 6 19267841 (1), 18571707 (1)
    polyinosinic-polycytidylic acid 59.3 3 18571707 (1), 20181884 (1)
    chloroquine 53.7 3 12738885 (1), 15804288 (1)
    peptidoglycan 44.4 3 19843090 (1), 17332440 (1)

    Search CenterWatch for drugs/clinical trials and news about TLR7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLR7 gene: 
    NM_016562.3  

    Unigene Cluster for TLR7:

    Toll-like receptor 7
    Hs.659215  [show with all ESTs]
    Unigene Representative Sequence: AF240467
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380659(uc004cvc.3) ENST00000484204
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLR7 (see all 11):
    hsa-miR-577 hsa-miR-34b* hsa-miR-548o hsa-miR-520a-5p hsa-miR-942 hsa-miR-525-5p hsa-miR-1323 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTLR7 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR7
    Clone
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    OriGene clones in human, mouse for TLR7 (see all 7)
    OriGene ORF clones in mouse, rat for TLR7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLR7 (NM_016562)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7
    Sirion Biotech Customized lentivirus for stable overexpression of TLR7 
                         Customized lentivirus expression plasmids for stable overexpression of TLR7 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TLR7
    OriGene qSTAR qPCR primer pairs in human, mouse for TLR7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLR7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR7

    Additional mRNA sequence: 

    AB445659.1 AF240467.1 AF245702.1 AJ812651.1 AK313858.1 AY358292.1 BC033651.1 

    2 DOTS entries:

    DT.108231  DT.40306487 

    24 AceView cDNA sequences:

    AY358292 NM_016562 AI829331 BC033651 AF245702 AF240467 AI379982 AA831880 
    CB215428 BX114029 BM454483 BF510904 BG621854 N30597 AA845644 AA278673 
    CB047122 AI307338 CF529581 AA706705 AA768459 N41840 AA315247 CB047121 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLR7 expression in normal human tissues (normalized intensities)      TLR7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCTGAA
    TLR7 Expression
    About this image


    TLR7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             monocytes   
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer

    See TLR7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLR7

    SOURCE GeneReport for Unigene cluster: Hs.659215

    UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
    Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid
    pre-dendritic cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR7 (see all 7): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TLR7 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr71 , 5 toll-like receptor 71, 5 83.16(n)1
    80.84(a)1
      X (78.31 cM)5
    1707431  NM_133211.31  NP_573474.11 
     1673049295 
    chicken
    (Gallus gallus)
    Aves TLR71 toll-like receptor 7 67.02(n)
    64.8(a)
      418638  NM_001011688.1  NP_001011688.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLR76
    --
    Uncharacterized protein
    57(a)
    24(a)
    1 ↔ 1
    possible ortholog
    3(120031300-120038102)
    2(122504100-122506901)
    zebrafish
    (Danio rerio)
    Actinopterygii tlr71 toll-like receptor 7 58.21(n)
    57.07(a)
      100534776  XM_003199261.1  XP_003199309.1 


    ENSEMBL Gene Tree for TLR7 (if available)
    TreeFam Gene Tree for TLR7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLR7 gene
    ENSG000001733662  CD1802  TLR12  TLR92  TLR52  TLR102  TLR42  TLR82  
    TLR62  TLR32  TLR22  
    2 SIMAP similar genes for TLR7 using alignment to 3 protein entries:     TLR7_HUMAN (see all proteins):
    TLR8    TLR9

    TLR7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/610 SNPs in TLR7 are shown (see all 610)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919922581,2
    --12798811(+) GGCAAA/GTATCA 1 -- us2k10--------
    rs1847690761,2
    --12798826(+) AAATCC/TTATTG 1 -- us2k10--------
    rs1389884401,2
    C--12798914(+) CCCCAA/GTAACA 1 -- us2k10--------
    rs1875862711,2
    --12798964(+) AGGGTC/TCTGCC 1 -- us2k10--------
    rs28978271,2
    C,F,A,H--12798980(+) ACAGAT/CGGCAT 1 -- us2k19Minor allele frequency- C:0.87NS EA NA 562
    rs1441896991,2
    C--12799182(+) GCCAAC/TGCAGG 1 -- us2k10--------
    rs1913286101,2
    --12799195(+) CAGGCA/GGAGGG 1 -- us2k10--------
    rs1842725991,2
    --12799206(+) AGCCAA/GAGGGA 1 -- us2k10--------
    rs1891669681,2
    --12799208(+) CCAGAG/TGGAGG 1 -- us2k10--------
    rs1815769181,2
    --12799218(+) GCAGGC/TTCTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLR7 (12885202 - 12908499 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TLR7: --

    Human Gene Mutation Database (HGMD): TLR7

    Locus Specific Mutation Databases (LSDB): TLR7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR7
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300365    OMIM disorders: --

    20/59 diseases for TLR7 (see all 59):    About MalaCards
    anogenital venereal wart    superficial basal cell carcinoma    congenital heart block    influenza
    molluscum contagiosum    lyme disease    pandas    actinic keratosis
    bronchiolitis    bronchiolitis obliterans    biliary atresia    basal cell carcinoma
    otitis media    dengue hemorrhagic fever    herpes simplex    keratosis
    was-related disorders    vaginitis    measles    viral hepatitis

    7 diseases from the University of Copenhagen DISEASES database for TLR7:
    Lupus erythematosus     Connective tissue disease     Influenza     Anogenital venereal wart
    Basal cell carcinoma     Actinic keratosis     Nephritis

    TLR7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/13 Novoseek inferred disease relationships for TLR7 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 60.7 12 14530316 (1), 17023556 (1), 17360657 (1), 19426550 (1) (see all 11)
    lupus erythematosus systemic 39.5 4 18613842 (1), 18373699 (1), 19714644 (1), 17979852 (1)
    necrosis 36.8 9 18765427 (1), 19267841 (1), 16960116 (1), 19251253 (1) (see all 6)
    inflammation 32.3 5 14530316 (1), 19019962 (1), 19129482 (1), 20232824 (1) (see all 5)
    hepatitis c 32.2 1 18021446 (1)
    tumors 26.6 18 20237413 (3), 17066089 (2), 18439103 (2), 17201162 (1) (see all 8)
    influenza 21.9 4 15593126 (2), 14976261 (1), 17082628 (1)
    infectious disease 20.9 2 16365416 (1), 19426145 (1)
    leukemia lymphocytic chronic 2.25 1 17066089 (1)
    herpes simplex 0 1 16423052 (1)

    Genetic Association Database (GAD): TLR7
    Human Genome Epidemiology (HuGE) Navigator: TLR7 (33 documents)

    Export disorders for TLR7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLR7 gene, integrated from 9 sources (see all 358):
    (articles sorted by number of sources associating them with TLR7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 9 Du X.... Beutler B. (2000)
    2. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. (PubMed id 18088248)1, 4, 9 Schott E....Berg T. (2008)
    3. A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. (PubMed id 19114863)1, 4, 9 Oh D.Y....Schumann R.R. (2009)
    4. Toll-like receptor polymorphisms and age-related macular degeneration. (PubMed id 18385087)1, 4, 9 Edwards A.O....Tosakulwong N. (2008)
    5. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PubMed id 17964520)1, 4, 9 Cheng P.L....Lin T.M. (2007)
    6. Hodgkin disease risk: Role of genetic polymorphisms a nd gene-gene interactions in inflammation pathway genes. (PubMed id 21061265)1, 4 Monroy C.M....El-Zein R.A. (2011)
    7. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    8. Polymorphisms in innate immunity genes associated wit h development of bronchiolitis obliterans after lung transplantation. (PubMed id 20227302)1, 4 Kastelijn E.A....van den Bosch J.M. (2010)
    9. Association of TLR7 copy number variation with suscep tibility to childhood-onset systemic lupus erythematosus in Mexican population. (PubMed id 20525845)1, 4 GarcA-a-Ortiz H....Orozco L. (2010)
    10. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51284 HGNC: 15631 AceView: TLR7 Ensembl:ENSG00000196664 euGenes: HUgn51284
    ECgene: TLR7 Kegg: 51284 H-InvDB: TLR7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLR7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLR7 gene:
    Search GeneIP for patents involving TLR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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