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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLR7 Gene

protein-coding   GIFtS: 65
GCID: GC0XP012885

toll-like receptor 7
 Explore 60 diseases affiliated with
TLR7 via
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Biological research products
for TLR7    

Aliases
for TLR7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Toll-Like Receptor 71 2
TLR7-Like1
Toll-Like Receptor 7-Like2

External Ids:    HGNC: 156311   Entrez Gene: 512842   Ensembl: ENSG000001966647   OMIM: 3003655   UniProtKB: Q9NYK13   

Export aliases for TLR7 gene to outside databases

Previous GC identifers: GC0XP012078 GC0XP011651 GC0XP012181 GC0XP012246 GC0XP012644 GC0XP012795 GC0XP010651


Summaries
for TLR7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TLR7:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share
structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective
immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung,
placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing
TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine
secretion and the inflammatory response (By similarity)

summary for TLR7:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR7 (TLR 7)


Genomic Views
for TLR7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167197.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR7 gene promoter:
         STAT1   AP-1   ATF-2   IRF-1   S8   FOXO4   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLR7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLR7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.3   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.3

TLR7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR7 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP012885:  view genomic region     (about GC identifiers)

Start:
 12,885,202 bp from pter      End:
 12,908,499 bp from pter
Size:
 23,298 bases      Orientation:
 plus strand

Proteins
for TLR7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1 (See protein sequence)
Recommended Name: Toll-like receptor 7 precursor  
Size: 1049 amino acids; 120922 Da
Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By
similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to
endosome and lysosome upon stimulation with agonist (By similarity)
Secondary accessions: D1CS69 Q9NR98

Explore the universe of human proteins at neXtProt for TLR7: NX_Q9NYK1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYK1

    • TLR7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057646.1  
    ENSEMBL proteins: 
     ENSP00000370034  
    Reactome Protein details: Q9NYK1
    Human Recombinant Protein Products: 
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    Novus Biologicals TLR7 Proteins
    Novus Biologicals TLR7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLR7

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005737cytoplasm IDA19740627
    GO:0005764lysosome ISS--
    GO:0005768endosome ISS--
    GO:0005783endoplasmic reticulum ISS--


    TLR7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TLR7

    Protein Domains /
    Families
    for TLR7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLR7 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR026880 TLR7
     IPR000157 TIR_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYK1

    ProtoNet protein and cluster: Q9NYK1

    3 Blocks protein families:
    IPB000157 TIR domain
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 27 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    Function
    for TLR7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing
    TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine
    secretion and the inflammatory response (By similarity)

    miRNA
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    hsa-miR-577 hsa-miR-34b* hsa-miR-548o hsa-miR-520a-5p hsa-miR-942 hsa-miR-525-5p hsa-miR-1323 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TLR7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR7 (see all 7)
    OriGene shRNA RFP: TLR7
    OriGene siRNA: TLR7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TLR7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR7 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TLR7 (NM_016562)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7 

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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR7

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA16111635
    GO:0003727single-stranded RNA binding ISS--
    GO:0004872receptor activity ----
    GO:0005515protein binding ----
    GO:0008144drug binding IEA--


    TLR7 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tlr7tm1Aki for TLR7
         5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tlr7):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  renal/urinary system 

    TLR7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TLR7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    		TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.85
    		Toll Like Receptor 9 (TLR9) Cascade0.81
    		Toll Like Receptor 7/8 (TLR7/8) Cascade0.83
    		Toll-Like Receptors Cascades0.53
    		MyD88 dependent cascade initiated on endosome0.83
    2Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Inflammasome Activation Pathways0.29
    3Endosomal TLRs pass through the Golgi
    		Endosomal TLRs pass through the Golgi1.00
    		Trafficking and processing of endosomal TLR0.42
    		UNC93B1 delivers endosomal full-length TLRs to endolysosome1.00
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    5Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    		Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response1.00
    		Immune response_TLR signaling pathways0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TLR7
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5 R&D Systems Pathways for TLR7
        Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways
    Th17 Differentiation

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR7 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR7
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR7
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR7
        Immune response TLR signaling pathways

    1 BioSystems Pathway for TLR7 
        Toll-like receptor signaling pathway

    5/11        Reactome Pathways for TLR7 (see all 11)
        Endosomal TLRs pass through the Golgi
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Toll-Like Receptors Cascades
    UNC93B1 delivers endosomal full-length TLRs to endolysosome
    MyD88 dependent cascade initiated on endosome


    3         Kegg Pathways  (Kegg details for TLR7):
        Toll-like receptor signaling pathway
    Measles
    Influenza A


    TLR7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for TLR7 (Q9NYK13 ENSP000003700344) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TLR8Q9NR973, ENSP000002180324I2D: score=1 STRING: ENSP00000218032
    MYD88Q998363, ENSP000003796254I2D: score=2 STRING: ENSP00000379625
    CD14P085713I2D: score=2 
    UNC93B1Q9H1C43I2D: score=1 
    CNPY3ENSP000003619264STRING: ENSP00000361926
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway ----
    GO:0002282microglial cell activation involved in immune response IEA--
    GO:0006954inflammatory response IEA--
    GO:0007252I-kappaB phosphorylation IDA19740627
    GO:0032722positive regulation of chemokine production IDA19740627


    TLR7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLR7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TLR7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TLR7

    Compounds for TLR7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    RWJ 21757Toll-like receptor 7 (TLR7) agonist[121288-39-9]
    ResiquimodToll-like receptor 7 (TLR 7) agonist[144875-48-9]
    ImiquimodToll-like receptor 7 (TLR7) agonist[99011-02-6]

    2 DrugBank Compounds for TLR7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Imiquimod-- 99011-02-6targetagonist12527213 12470615 15072849 15068862 14616353 11752352
    Hydroxychloroquine-- 118-42-3targetantagonist14579285 11752352 18220957

    9 Novoseek chemical compound relationships for TLR7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    resiquimod 91.7 6 14616338 (1), 15827165 (1), 14638493 (1), 15778362 (1)
    imidazoquinoline 88.7 4 19285861 (1), 18439678 (1), 18176600 (1)
    loxoribine 86.9 2 19685493 (1), 15778362 (1)
    imiquimod 81.9 22 18439678 (2), 19516264 (2), 16254370 (2), 20124101 (1) (see all 16)
    poly(i-c) 68.4 4 15804288 (2), 14530316 (1), 14530357 (1)
    lipoteichoic acid 60.8 6 19267841 (1), 18571707 (1)
    polyinosinic-polycytidylic acid 59.3 3 18571707 (1), 20181884 (1)
    chloroquine 53.7 3 12738885 (1), 15804288 (1)
    peptidoglycan 44.4 3 19843090 (1), 17332440 (1)

    Search CenterWatch for drugs/clinical trials and news about TLR7 

    Transcripts
    for TLR7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLR7 gene: 
    NM_016562.3  

    Unigene Cluster for TLR7:

    Toll-like receptor 7
    Hs.659215  [show with all ESTs]
    Unigene Representative Sequence: AF240467
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380659(uc004cvc.3) ENST00000484204

    miRNA
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    hsa-miR-577 hsa-miR-34b* hsa-miR-548o hsa-miR-520a-5p hsa-miR-942 hsa-miR-525-5p hsa-miR-1323 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TLR7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR7 (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR7

    Additional cDNA sequence: 

    AB445659.1 AF240467.1 AF245702.1 AJ812651.1 AK313858.1 AY358292.1 BC033651.1 

    2 DOTS entries:

    DT.108231  DT.40306487 

    24 AceView cDNA sequences:

    AI379982 BC033651 NM_016562 AY358292 CB215428 BX114029 AI829331 AA831880 
    AF245702 AF240467 BG621854 N30597 BF510904 BM454483 AA845644 AA278673 
    CF529581 AI307338 AA706705 AA768459 CB047122 N41840 AA315247 CB047121 

    GeneLoc Exon Structure


    Expression
    for TLR7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLR7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGCTCTGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TLR7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLR7

    SOURCE GeneReport for Unigene cluster: Hs.659215

    UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1
    Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid
    pre-dendritic cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR7 (see all 7): 
              Innate & Adaptive Immune Responses in human mouse rat
              Antiviral Response in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR7
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR7

    Orthologs
    for TLR7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLR7 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TLR71 toll-like receptor 7 67.02(n)
    64.8(a)    		   418638  NM_001011688.1  NP_001011688.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TLR76
    		 --
    		 58(a)
    		 1 ↔ 1
    		 3(120034944-120038102)
    zebrafish
    (Danio rerio)    		 Actinopterygii tlr71 toll-like receptor 7 58.21(n)
    57.07(a)    		   100534776  XM_003199261.1  XP_003199309.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG78963   -- 26(a)   99D1   --


    ENSEMBL Gene Tree for TLR7 (if available)
    TreeFam Gene Tree for TLR7 (if available) 

    Paralogs
    for TLR7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLR7 gene
    CD1802  ENSG000001733662  TLR12  TLR92  TLR52  TLR102  LRRC332  TLR42  
    TLR82  TLR62  LRRC322  TLR32  TLR22  
    2 SIMAP similar genes for TLR7 using alignment to 3 protein entries:     TLR7_HUMAN (see all proteins):
    TLR8    TLR9

    TLR7 for paralogs           About GeneDecksing



    Genomic Variants
    for TLR7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/550 NCBI SNPs in TLR7 are shown (see all 550)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1919922581,2
    		--12883377(+) GGCAAA/GTATCA 1 -- us2k10--------
    rs1847690761,2
    		--12883392(+) AAATCC/TTATTG 1 -- us2k10--------
    rs1389884401,2
    		--12883480(+) CCCCAA/GTAACA 1 -- us2k10--------
    rs1875862711,2
    		--12883530(+) AGGGTC/TCTGCC 1 -- us2k10--------
    rs28978271,2
    		C,F,A,H,--12883546(+) ACAGAT/CGGCAT 1 -- us2k19Minor allele frequency- C:0.87NS EA NA 562
    rs1441896991,2
    		--12883748(+) GCCAAC/TGCAGG 1 -- us2k10--------
    rs1913286101,2
    		--12883761(+) CAGGCA/GGAGGG 1 -- us2k10--------
    rs1842725991,2
    		--12883772(+) AGCCAA/GAGGGA 1 -- us2k10--------
    rs1891669681,2
    		--12883774(+) CCAGAG/TGGAGG 1 -- us2k10--------
    rs1815769181,2
    		--12883784(+) GCAGGC/TTCTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLR7 (12885202 - 12908499 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TLR7: --
    Human Gene Mutation Database (HGMD): TLR7

    Locus Specific Mutation Databases (LSDB): TLR7

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR7
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR7

    Disorders / Diseases
    for TLR7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLR7 for disorders           About GeneDecksing

    OMIM gene information: 300365    OMIM disorders: --

    20/60 diseases for TLR7 (see all 60):    About MalaCards
    anogenital venereal wart    age related macular degeneration    otitis media    molluscum contagiosum
    superficial basal cell carcinoma    heart block    dengue hemorrhagic fever    congenital heart block
    actinic keratosis    hemorrhagic fever    macular degeneration    basal cell carcinoma
    herpes simplex    lupus erythematosus    bronchiolitis obliterans    haemophilus influenzae
    biliary atresia    systemic lupus erythematosus    bronchiolitis    chronic lymphocytic leukemia

    6 diseases from the University of Copenhagen DISEASES database for TLR7:
    Systemic lupus erythematosus     Influenza     Anogenital venereal wart     Basal cell carcinoma
    Actinic keratosis     Nephritis

    10/13 Novoseek disease relationships for TLR7 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 60.7 12 14530316 (1), 17023556 (1), 17360657 (1), 19426550 (1) (see all 11)
    lupus erythematosus systemic 39.5 4 18613842 (1), 18373699 (1), 19714644 (1), 17979852 (1)
    necrosis 36.8 9 18765427 (1), 19267841 (1), 16960116 (1), 19251253 (1) (see all 6)
    inflammation 32.3 5 14530316 (1), 19019962 (1), 19129482 (1), 20232824 (1) (see all 5)
    hepatitis c 32.2 1 18021446 (1)
    tumors 26.6 18 20237413 (3), 17066089 (2), 18439103 (2), 17201162 (1) (see all 8)
    influenza 21.9 4 15593126 (2), 14976261 (1), 17082628 (1)
    infectious disease 20.9 2 16365416 (1), 19426145 (1)
    leukemia lymphocytic chronic 2.25 1 17066089 (1)
    herpes simplex 0 1 16423052 (1)

    Human Genome Epidemiology (HuGE) Navigator: TLR7 (33 documents)

    Export disorders for TLR7 gene to outside databases

    Publications
    for TLR7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLR7 gene, integrated from 9 sources (see all 345):
    (articles sorted by number of sources associating them with TLR7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 9 Du X.... Beutler B. (2000)
    2. The heterogeneous allelic repertoire of human toll-li ke receptor (TLR) genes. (PubMed id 19924287)1, 2 Georgel P....Bahram S. (2009)
    3. TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. (PubMed id 18250417)1, 2 Gantier M.P....Williams B.R. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. (PubMed id 11022120)1, 2 Chuang T.-H. and Ulevitch R.J. (2000)
    7. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. (PubMed id 18088248)1, 9 Schott E....Berg T. (2008)
    8. Impaired expression and function of toll-like recepto r 7 in hepatitis C virus infection in human hepatoma cells. (PubMed id 19821521)1, 9 Chang S....Szabo G. (2010)
    9. TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation. (PubMed id 19164127)1, 9 LarangAc A....Kerdine-RAPmer S. (2009)
    10. Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-alpha production. (PubMed id 17371961)1, 9 Berghofer B....Hackstein H. (2007)

    External Searches for TLR7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TLR7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51284 HGNC: 15631 AceView: TLR7 Ensembl:ENSG00000196664 euGenes: HUgn51284
    ECgene: TLR7 Kegg: 51284 H-InvDB: TLR7

    Other Databases showing TLR7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TLR7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLR7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TLR7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLR7 gene:
    Search GeneIP for patents involving TLR7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TLR7 gene

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    About This Section

     
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