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Aliases for TLR7 Gene

Aliases for TLR7 Gene

  • Toll-Like Receptor 7 2 3
  • Toll-Like Receptor 7-Like 3
  • TLR7-Like 3

External Ids for TLR7 Gene

Previous GeneCards Identifiers for TLR7 Gene

  • GC0XP012078
  • GC0XP011651
  • GC0XP012181
  • GC0XP012246
  • GC0XP012644
  • GC0XP012795
  • GC0XP010651
  • GC0XP012885

Summaries for TLR7 Gene

Entrez Gene Summary for TLR7 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR7 Gene

TLR7 (Toll-Like Receptor 7) is a Protein Coding gene. Diseases associated with TLR7 include anogenital venereal wart and congenital heart block. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include drug binding and single-stranded RNA binding. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR7 Gene

  • Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Tocris Summary for TLR7 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like receptors are activated by molecules associated with biological threat and are highly specific towards evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR7 Gene

Genomics for TLR7 Gene

Regulatory Elements for TLR7 Gene

Genomic Location for TLR7 Gene

Start:
12,867,083 bp from pter
End:
12,890,380 bp from pter
Size:
23,298 bases
Orientation:
Plus strand

Genomic View for TLR7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR7 Gene

Proteins for TLR7 Gene

  • Protein details for TLR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYK1-TLR7_HUMAN
    Recommended name:
    Toll-like receptor 7
    Protein Accession:
    Q9NYK1
    Secondary Accessions:
    • D1CS69
    • Q9NR98

    Protein attributes for TLR7 Gene

    Size:
    1049 amino acids
    Molecular mass:
    120922 Da
    Quaternary structure:
    • Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity).

neXtProt entry for TLR7 Gene

Proteomics data for TLR7 Gene at MOPED

Post-translational modifications for TLR7 Gene

  • Glycosylation at Asn66, Asn69, Asn167, Asn202, Asn215, Asn361, Asn413, Asn488, Asn523, Asn534, Asn590, Asn679, Asn720, and Asn799
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLR7 (TLR7)

No data available for DME Specific Peptides for TLR7 Gene

Domains for TLR7 Gene

Gene Families for TLR7 Gene

Suggested Antigen Peptide Sequences for TLR7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYK1

UniProtKB/Swiss-Prot:

TLR7_HUMAN :
  • Q9NYK1
Domain:
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 27 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR7: view

Function for TLR7 Gene

Molecular function for TLR7 Gene

UniProtKB/Swiss-Prot Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Gene Ontology (GO) - Molecular Function for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 16111635
GO:0003727 single-stranded RNA binding ISS --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding --
GO:0008144 drug binding IEA --
genes like me logo Genes that share ontologies with TLR7: view
genes like me logo Genes that share phenotypes with TLR7: view

Animal Models for TLR7 Gene

MGI Knock Outs for TLR7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR7

Clone Products

  • Addgene plasmids for TLR7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TLR7 Gene

Localization for TLR7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR7 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR7 Gene COMPARTMENTS Subcellular localization image for TLR7 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 4
golgi apparatus 4
lysosome 4
plasma membrane 4
vacuole 4
extracellular 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IDA 19740627
GO:0005764 lysosome ISS --
GO:0005768 endosome ISS --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with TLR7: view

Pathways for TLR7 Gene

genes like me logo Genes that share pathways with TLR7: view

PCR Array Products

Gene Ontology (GO) - Biological Process for TLR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with TLR7: view

Compounds for TLR7 Gene

(5) Tocris Compounds for TLR7 Gene

Compound Action Cas Number
C34 TLR4 inhibitor [40592-88-9]
CU CPT 4a Selective TLR3 inhibitor [1279713-77-7]
Pam3CSK4 TLR1/2 agonist; induces cytokine production [112208-00-1]
Poly(I:C) TLR3 agonist [24939-03-5]
Resiquimod Toll-like receptor 7 (TLR7) agonist [144875-48-9]

(2) Drugbank Compounds for TLR7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Hydroxychloroquine
118-42-3 target antagonist
Imiquimod
99011-02-6 target agonist

(3) IUPHAR Ligand for TLR7 Gene

Ligand Type Action Affinity Pubmed IDs
imiquimod Agonist Agonist
R848 Agonist Agonist
loxoribine Agonist Agonist

(9) Novoseek inferred chemical compound relationships for TLR7 Gene

Compound -log(P) Hits PubMed IDs
resiquimod 91.7 4
imidazoquinoline 88.7 3
loxoribine 86.9 2
imiquimod 81.9 19
poly(i-c) 68.4 4
genes like me logo Genes that share compounds with TLR7: view

Transcripts for TLR7 Gene

mRNA/cDNA for TLR7 Gene

(24) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLR7 Gene

Toll-like receptor 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR7

Clone Products

  • Addgene plasmids for TLR7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLR7 Gene

No ASD Table

Relevant External Links for TLR7 Gene

GeneLoc Exon Structure for
TLR7
ECgene alternative splicing isoforms for
TLR7

Expression for TLR7 Gene

mRNA expression in normal human tissues for TLR7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TLR7 Gene

SOURCE GeneReport for Unigene cluster for TLR7 Gene Hs.659215

mRNA Expression by UniProt/SwissProt for TLR7 Gene

Q9NYK1-TLR7_HUMAN
Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells
genes like me logo Genes that share expressions with TLR7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TLR7 Gene

Orthologs for TLR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR7 35
  • 99.65 (n)
  • 99.52 (a)
TLR7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLR7 35
  • 87.5 (n)
  • 86.55 (a)
TLR7 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR7 35
  • 86.91 (n)
  • 85.61 (a)
TLR7 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr7 35
  • 83.16 (n)
  • 80.84 (a)
Tlr7 16
Tlr7 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TLR7 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr7 35
  • 83.25 (n)
  • 80.65 (a)
chicken
(Gallus gallus)
Aves TLR7 35
  • 67.25 (n)
  • 65.3 (a)
TLR7 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLR7 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlr7 35
  • 63.44 (n)
  • 61.68 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr7 35
  • 58.39 (n)
  • 57.28 (a)
tlr7 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7896 37
  • 26 (a)
Species with no ortholog for TLR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR7 Gene

ENSEMBL:
Gene Tree for TLR7 (if available)
TreeFam:
Gene Tree for TLR7 (if available)

Paralogs for TLR7 Gene

Paralogs for TLR7 Gene

Selected SIMAP similar genes for TLR7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TLR7: view

Variants for TLR7 Gene

Sequence variations from dbSNP and Humsavar for TLR7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs179008 - 12,885,540(+) GAGAC(A/C/T)AATTC reference, missense
rs179009 -- 12,885,361(-) CCCCA(A/C/T)GACTG intron-variant
rs179010 -- 12,884,766(+) TCACC(C/T)AGGCA intron-variant
rs179011 -- 12,883,841(-) TCACC(A/C)CCCTA intron-variant
rs179012 -- 12,883,443(-) TTGTC(C/T)GGCTT intron-variant

Relevant External Links for TLR7 Gene

HapMap Linkage Disequilibrium report
TLR7
Human Gene Mutation Database (HGMD)
TLR7
Locus Specific Mutation Databases (LSDB)
TLR7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLR7 Gene

Disorders for TLR7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TLR7 Gene including...

Search for TLR7 Gene in MalaCards »

(13) Novoseek inferred disease relationships for TLR7 Gene

Disease -log(P) Hits PubMed IDs
virus infection 60.7 11
lupus erythematosus systemic 39.5 4
necrosis 36.8 6
inflammation 32.3 5
hepatitis c 32.2 1

Relevant External Links for TLR7

Genetic Association Database (GAD)
TLR7
Human Genome Epidemiology (HuGE) Navigator
TLR7
genes like me logo Genes that share disorders with TLR7: view

No data available for UniProtKB/Swiss-Prot for TLR7 Gene

Publications for TLR7 Gene

  1. Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. (PMID: 17964520) Cheng P.L. … Lin T.M. (Transl Res 2007) 3 23 48
  2. Toll-like receptor polymorphisms and age-related macular degeneration. (PMID: 18385087) Edwards A.O. … Tosakulwong N. (Invest. Ophthalmol. Vis. Sci. 2008) 3 23 48
  3. A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression. (PMID: 19114863) Oh D.Y. … Schumann R.R. (AIDS 2009) 3 23 48
  4. Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. (PMID: 18088248) Schott E. … Berg T. (J. Viral Hepat. 2008) 3 23 48
  5. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PMID: 11022119) Du X. … Beutler B. (Eur. Cytokine Netw. 2000) 2 3 4

Products for TLR7 Gene

  • Addgene plasmids for TLR7

Sources for TLR7 Gene

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