TLR7 Gene
protein-coding GIFtS: 65
GCID: GC0XP012885
|
|
toll-like receptor 7
| |
Aliases
for TLR7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Toll-Like Receptor 71 2 | | TLR7-Like1 | | Toll-Like Receptor 7-Like2 |
Export aliases for TLR7 gene to outside databasesPrevious GC identifers: GC0XP012078 GC0XP011651 GC0XP012181 GC0XP012246 GC0XP012644 GC0XP012795 GC0XP010651 |
Summaries
for TLR7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TLR7:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role inpathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and sharestructural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that areexpressed on infectious agents, and mediate the production of cytokines necessary for the development of effectiveimmunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung,placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune responseagainst pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensingTLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokinesecretion and the inflammatory response (By similarity)
 summary
for TLR7: Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.
Gene Wiki entry for TLR7 (TLR 7)
|
Genomic Views
for TLR7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TLR7 gene promoter:
STAT1 AP-1 ATF-2 IRF-1 S8 FOXO4 STAT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TLR7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.3 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.3TLR7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP012885: view genomic region
(about GC identifiers)
Start:
|
12,885,202 bp from pter |
End:
|
12,908,499 bp from pter |
Size:
|
23,298 bases |
Orientation:
|
plus strand |
|
Proteins
for TLR7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1 (See
protein sequence)Recommended Name: Toll-like receptor 7 precursor Size: 1049 amino acids; 120922 Da
Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (Bysimilarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum toendosome and lysosome upon stimulation with agonist (By similarity)
Secondary accessions: D1CS69 Q9NR98Explore the universe of human proteins at neXtProt for TLR7: NX_Q9NYK1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYK1
TLR7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057646.1
ENSEMBL proteins: ENSP00000370034 Reactome Protein details: Q9NYK1
Human Recombinant Protein Products for TLR7:
Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table
TLR7 for ontologies About GeneDecksing
TLR7 Antibody Products:
Assay Products for TLR7: |
Protein
Domains /
Families
for TLR7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TLR7 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9NYK1ProtoNet protein and cluster: Q9NYK1 3 Blocks protein families: IPB000157 TIR domain IPB000372 Cysteine-rich flanking region IPB000483 Cysteine-rich flanking region
UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1Similarity: Belongs to the Toll-like receptor familySimilarity: Contains 27 LRR (leucine-rich) repeatsSimilarity: Contains 1 TIR domain |
Function
for TLR7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TLR7_HUMAN, Q9NYK1Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune responseagainst pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensingTLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokinesecretion and the inflammatory response (By similarity) Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
TLR7 for ontologies About GeneDecksing
Phenotypes:
5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Tlr7):
TLR7 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Tlr7tm1Aki for TLR7
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TLR7 (NM_016562) | |  | Sino Biological Human cDNA Clone for TLR7 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLR7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR7 |
|
Pathways & Interactions
for TLR7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Toll-like receptor signaling pathway | | | 3 | Endosomal TLRs pass through the Golgi | | | 4 | Immune System | | | 5 | Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TLR7
5  R&D Systems Pathways for TLR7
5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR7 (see all 8)
1 
Cell Signaling Technology (CST) Pathway for TLR7
1 Tocris Bioscience Pathway for TLR7
1  GeneGo (Thomson Reuters) Pathway for TLR7
1  BioSystems Pathway for TLR7
5/11 
Reactome Pathways for TLR7 (see all 11)
3 
Kegg Pathways (Kegg details for TLR7):
TLR7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/13 Interacting proteins for TLR7 (Q9NYK13 ENSP000003700344) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
TLR7 for ontologies About GeneDecksing
|
Drugs & Compounds
for TLR7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TLR7 for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for TLR7 |
Compounds for TLR7 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| RWJ 21757 | Toll-like receptor 7 (TLR7) agonist | [121288-39-9] | | Resiquimod | Toll-like receptor 7 (TLR 7) agonist | [144875-48-9] | | Imiquimod | Toll-like receptor 7 (TLR7) agonist | [99011-02-6] |
2 DrugBank Compounds for TLR7 About this table
9 Novoseek chemical compound relationships for TLR7 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| resiquimod |
91.7 |
6 |
14616338 (1), 15827165 (1), 14638493 (1), 15778362 (1) |
| imidazoquinoline |
88.7 |
4 |
19285861 (1), 18439678 (1), 18176600 (1) |
| loxoribine |
86.9 |
2 |
19685493 (1), 15778362 (1) |
| imiquimod |
81.9 |
22 |
18439678 (2), 19516264 (2), 16254370 (2), 20124101 (1) (see all 16) |
| poly(i-c) |
68.4 |
4 |
15804288 (2), 14530316 (1), 14530357 (1) |
| lipoteichoic acid |
60.8 |
6 |
19267841 (1), 18571707 (1) |
| polyinosinic-polycytidylic acid |
59.3 |
3 |
18571707 (1), 20181884 (1) |
| chloroquine |
53.7 |
3 |
12738885 (1), 15804288 (1) |
| peptidoglycan |
44.4 |
3 |
19843090 (1), 17332440 (1) |
Search CenterWatch for drugs/clinical trials and news about TLR7
|
Transcripts
for TLR7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TLR7 gene: NM_016562.3 Unigene Cluster for TLR7: Toll-like receptor 7 Hs.659215 [show with all ESTs]Unigene Representative Sequence: AF2404672 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380659(uc004cvc.3) ENST00000484204
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TLR7 (NM_016562) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLR7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7 |
Additional cDNA sequence: AB445659.1 AF240467.1 AF245702.1 AJ812651.1 AK313858.1 AY358292.1 BC033651.1 2 DOTS entries: DT.108231 DT.40306487 24 AceView cDNA sequences: AI379982 BC033651 NM_016562 AY358292 CB215428 BX114029 AI829331 AA831880 AF245702 AF240467 BG621854 N30597 BF510904 BM454483 AA845644 AA278673 CF529581 AI307338 AA706705 AA768459 CB047122 N41840 AA315247 CB047121
GeneLoc Exon Structure
|
Expression
for TLR7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TLR7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCTCTGAA
About this image
See TLR7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLR7
SOURCE GeneReport for Unigene cluster: Hs.659215
UniProtKB/Swiss-Prot: TLR7_HUMAN, Q9NYK1Tissue specificity: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoidpre-dendritic cells
SABiosciences Expression via Pathway-Focused PCR Arrays including TLR7 (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLR7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLR7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR7 |
Orthologs
for TLR7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TLR7 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for TLR7 (if available)
TreeFam Gene Tree for TLR7 (if available) |
Paralogs
for TLR7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TLR7 gene
- CD1802 ENSG000001733662 TLR12 TLR92 TLR52 TLR102 LRRC332 TLR42
- TLR82 TLR62 LRRC322 TLR32 TLR22
2 SIMAP similar genes for TLR7 using alignment to 3 protein entries: TLR7_HUMAN (see all proteins):TLR8 TLR9
TLR7 for paralogs About GeneDecksing
|
Genomic Variants
for TLR7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TLR7 (12885202 - 12908499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TLR7: --
Human Gene Mutation Database (HGMD): TLR7
Locus Specific Mutation Databases (LSDB): TLR7
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR7 |
|
Disorders
/ Diseases
for TLR7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TLR7 for disorders About GeneDecksing
OMIM gene information: 300365
OMIM disorders: --
20/60  diseases for TLR7 (see all 60): About MalaCardsanogenital venereal wart age related macular degeneration otitis media molluscum contagiosum
superficial basal cell carcinoma heart block dengue hemorrhagic fever congenital heart block
actinic keratosis hemorrhagic fever macular degeneration basal cell carcinoma
herpes simplex lupus erythematosus bronchiolitis obliterans haemophilus influenzae
biliary atresia systemic lupus erythematosus bronchiolitis chronic lymphocytic leukemia
6 diseases from the University of Copenhagen DISEASES database for TLR7:Systemic lupus erythematosus Influenza Anogenital venereal wart Basal cell carcinoma
Actinic keratosis Nephritis 10/13 Novoseek disease relationships for TLR7 gene (see all 13) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| virus infection |
60.7 |
12 |
14530316 (1), 17023556 (1), 17360657 (1), 19426550 (1) (see all 11) |
| lupus erythematosus systemic |
39.5 |
4 |
18613842 (1), 18373699 (1), 19714644 (1), 17979852 (1) |
| necrosis |
36.8 |
9 |
18765427 (1), 19267841 (1), 16960116 (1), 19251253 (1) (see all 6) |
| inflammation |
32.3 |
5 |
14530316 (1), 19019962 (1), 19129482 (1), 20232824 (1) (see all 5) |
| hepatitis c |
32.2 |
1 |
18021446 (1) |
| tumors |
26.6 |
18 |
20237413 (3), 17066089 (2), 18439103 (2), 17201162 (1) (see all 8) |
| influenza |
21.9 |
4 |
15593126 (2), 14976261 (1), 17082628 (1) |
| infectious disease |
20.9 |
2 |
16365416 (1), 19426145 (1) |
| leukemia lymphocytic chronic |
2.25 |
1 |
17066089 (1) |
| herpes simplex |
0 |
1 |
16423052 (1) |
Human Genome Epidemiology (HuGE) Navigator: TLR7 (33 documents)
Export disorders for TLR7 gene to outside databases
|
Publications
for TLR7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TLR7 gene, integrated from 9 sources (see all 345):
(articles sorted by number of sources associating them with TLR7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. (PubMed id 11022119)1, 2, 3, 9 Du X.... Beutler B. (2000)
- The heterogeneous allelic repertoire of human toll-li ke receptor (TLR) genes. (PubMed id 19924287)1, 2 Georgel P....Bahram S. (2009)
- TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. (PubMed id 18250417)1, 2 Gantier M.P....Williams B.R. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Cloning and characterization of a sub-family of human Toll-like receptors: hTLR7, hTLR8 and hTLR9. (PubMed id 11022120)1, 2 Chuang T.-H. and Ulevitch R.J. (2000)
- Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. (PubMed id 18088248)1, 9 Schott E....Berg T. (2008)
- Impaired expression and function of toll-like recepto r 7 in hepatitis C virus infection in human hepatoma cells. (PubMed id 19821521)1, 9 Chang S....Szabo G. (2010)
- TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation. (PubMed id 19164127)1, 9 LarangAc A....Kerdine-RAPmer S. (2009)
- Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-alpha production. (PubMed id 17371961)1, 9 Berghofer B....Hackstein H. (2007)
|
External Searches for TLR7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TLR7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TLR7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TLR7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TLR7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TLR7 gene:
Search GeneIP for patents involving TLR7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TLR7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for TLR7 | | OriGene shRNA RFP for TLR7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLR7 | | | OriGene Protein Over-expression Lysate for TLR7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TLR7 | | OriGene 3'-UTR Clone for TLR7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TLR7 | | OriGene Custom Protein Services for TLR7 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLR7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR7 |
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| | Antibodies & Assays for TLR7 |
| | | | Tocris compounds for TLR7 |
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 | | | TLR7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR7 |
|  |  |  |  | | | | ThermoFisher Antibody for TLR7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR7 |
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