Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TLR6 Gene

protein-coding   GIFtS: 67
GCID: GC04M038828

Toll-Like Receptor 6

  See TLR6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Toll-Like Receptor 61 2
CD2862
CD286 Antigen3

External Ids:    HGNC: 167111   Entrez Gene: 103332   Ensembl: ENSG000001741307   OMIM: 6054035   UniProtKB: Q9Y2C93   

Export aliases for TLR6 gene to outside databases

Previous GC identifers: GC04P039066 GC04M038992 GC04M038663 GC04M038725 GC04M038650 GC04M038504 GC04M038149


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TLR6 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally
interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro
polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is
some populations.(provided by RefSeq, Jan 2011)

GeneCards Summary for TLR6 Gene:
TLR6 (toll-like receptor 6) is a protein-coding gene. Diseases associated with TLR6 include invasive aspergillosis, and oral cavity cancer. GO annotations related to this gene include transmembrane signaling receptor activity and protein heterodimerization activity. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9
Function: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes
diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B
activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating
lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer
surface protein A lipoprotein (OspA-L) cooperatively with TLR2

summary for TLR6 Gene:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLR6 gene promoter:
         E2F-4   E2F-3a   ATF-2   E2F-2   CREB   E2F   E2F-1   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR6 promoter sequence
   Search Chromatin IP Primers for TLR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p16.1

TLR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M038828:  view genomic region     (about GC identifiers)

Start:
38,825,325 bp from pter      End:
38,858,438 bp from pter
Size:
33,114 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9 (See protein sequence)
Recommended Name: Toll-like receptor 6 precursor  
Size: 796 amino acids; 91880 Da
Subunit: Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular
domains (By similarity)
Secondary accessions: B3Y640 B6CH35 B6RFS4 B6RFS5

Explore the universe of human proteins at neXtProt for TLR6: NX_Q9Y2C9

Explore proteomics data for TLR6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn144, Asn186, Asn214, Asn253, Asn285, Asn359, Asn423, Asn434, Asn583
  • Modification sites at PhosphoSitePlus

  • See TLR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006059.2  
    ENSEMBL proteins: 
     ENSP00000371376   ENSP00000424718   ENSP00000423326   ENSP00000389600  
    Reactome Protein details: Q9Y2C9

    TLR6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TLR6
    Enzo Life Sciences proteins for TLR6
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TLR6
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TLR6
    GenScript Custom Purified and Recombinant Proteins Services for TLR6
    Novus Biologicals TLR6 Proteins
    Novus Biologicals TLR6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR6

     
    Search eBioscience for Proteins for TLR6 

    TLR6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TLR6
    R&D Systems Antibodies for TLR6
    Cell Signaling Technology (CST) Antibodies for TLR6 
    OriGene Antibodies for TLR6
    OriGene Custom Antibody Services for TLR6
    Novus Biologicals TLR6 Antibodies
    Abcam antibodies for TLR6
    Cloud-Clone Corp. Antibodies for TLR6
    ThermoFisher Antibody for TLR6
    LSBio Antibodies in human, mouse, rat for TLR6

    TLR6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TLR6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLR6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLR6
    Cloud-Clone Corp. CLIAs for TLR6
    Search eBioscience for ELISAs for TLR6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR6
    Toll-like receptor family

    5 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR027187 TLR1/6
     IPR017241 Toll-like_receptor

    Graphical View of Domain Structure for InterPro Entry Q9Y2C9

    ProtoNet protein and cluster: Q9Y2C9

    3 Blocks protein domains:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 19 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TLR6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR6_HUMAN, Q9Y2C9
    Function: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes
    diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B
    activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating
    lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer
    surface protein A lipoprotein (OspA-L) cooperatively with TLR2

         Genatlas biochemistry entry for TLR6:
    Drosophila transmembrane receptor Toll homolog 6,predominantly expressed in spleen,thymus,ovary and lung

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10426995
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005515protein binding ----
    GO:0042498diacyl lipopeptide binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with TLR6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TLR6:
     Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tlr6):
     hematopoietic system  immune system  reproductive system 

    Find genes that share phenotypes with TLR6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tlr6tm1Aki for TLR6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLR6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLR6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TLR6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TLR6:
    hsa-miR-382 hsa-miR-130b* hsa-miR-4263 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTLR6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TLR6
    Predesigned siRNA for gene silencing in human, mouse, rat TLR6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TLR6

    Clone
    Products:
         
    OriGene clones in human, mouse for TLR6 (see all 6)
    OriGene ORF clones in mouse, rat for TLR6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLR6 (NM_006068)
    Sino Biological Human cDNA Clone for TLR6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR6
    Addgene plasmids for TLR6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TLR6
    Browse ESI BIO Cell Lines and PureStem Progenitors for TLR6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TLR6_HUMAN, Q9Y2C9: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle,
    phagosome membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    endosome1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10231569
    GO:0016021integral component of membrane ----
    GO:0030670phagocytic vesicle membrane IEA--
    GO:0035355Toll-like receptor 2-Toll-like receptor 6 protein complex IEA--

    Find genes that share ontologies with TLR6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TLR6 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    NOD-like Receptor Signaling Pathways0.58
    3NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    4Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47
    5TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41


    Find genes that share SuperPaths with TLR6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TLR6 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLR6 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR6
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR6
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR6
        Immune response TLR signaling pathways

    2 BioSystems Pathways for TLR6
        Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR6
        NF-kB (NFkB) Pathway

    2 Reactome Pathways for TLR6
        Toll Like Receptor TLR6:TLR2 Cascade
    MyD88:Mal cascade initiated on plasma membrane


    4 Kegg Pathways  (Kegg details for TLR6):
        Phagosome
    Toll-like receptor signaling pathway
    Chagas disease (American trypanosomiasis)
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR6 (see all 9): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TLR6 (Q9Y2C93 ENSP000003713764) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061873, ENSP000003081764I2D: score=2 STRING: ENSP00000308176
    TRAP1Q129313, ENSP000002469574I2D: score=2 STRING: ENSP00000246957
    MYD88Q998363, ENSP000003796254I2D: score=1 STRING: ENSP00000379625
    TLR2O606033, ENSP000002600104I2D: score=2 STRING: ENSP00000260010
    CD36P166713I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002282microglial cell activation involved in immune response IEA--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS10426995

    Find genes that share ontologies with TLR6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TLR6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Pam2CSK4TLR2/6 agonist; induces TNF-alpha production[868247-72-7]
    ResiquimodToll-like receptor 7 (TLR7) agonist[144875-48-9]
    Pam3CSK4TLR1/2 agonist; induces cytokine production[112208-00-1]
    Poly(I:C)TLR3 agonist[42424-50-0]
    ImiquimodToll-like receptor 7 (TLR7) agonist[99011-02-6]

    4 Novoseek inferred chemical compound relationships for TLR6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptidoglycan 66.9 12 18424724 (4), 15661917 (3), 12538701 (1), 12874299 (1) (see all 5)
    flagellin 55.1 1 19270494 (1)
    rantes 16.4 2 19117515 (1), 19019963 (1)
    lipid 0 1 19931471 (1)



    Find genes that share compounds with TLR6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TLR6 gene: 
    NM_006068.4  

    Unigene Cluster for TLR6:

    Toll-like receptor 6
    Hs.575090  [show with all ESTs]
    Unigene Representative Sequence: NM_006068
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381950(uc003gtm.3) ENST00000508254 ENST00000514655 ENST00000436693(uc010ifg.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TLR6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TLR6:
    hsa-miR-382 hsa-miR-130b* hsa-miR-4263 hsa-miR-3153
    SwitchGear 3'UTR luciferase reporter plasmidTLR6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TLR6
    Predesigned siRNA for gene silencing in human, mouse, rat TLR6
    Clone
    Products:
         
    OriGene clones in human, mouse for TLR6 (see all 6)
    OriGene ORF clones in mouse, rat for TLR6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLR6 (NM_006068)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR6
    Addgene plasmids for TLR6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TLR6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLR6
      QuantiTect SYBR Green Assays in human, mouse, rat TLR6
      QuantiFast Probe-based Assays in human, mouse, rat TLR6

    Additional mRNA sequence: 

    AB020807.1 AK313618.1 BC111755.1 

    5 DOTS entries:

    DT.439547  DT.40189829  DT.91841289  DT.101960681  DT.40289093 

    13 AceView cDNA sequences:

    NM_006068 AA810462 AB020807 AA381849 CA310973 CF136926 BI031573 AA831782 
    BQ337481 BE814766 BF170087 AI184710 BI031578 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TLR6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TLR6 Expression
    About this image


    TLR6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TLR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.575090

    UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9
    Tissue specificity: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and
    dermal microvessel endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR6 (see all 9): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TLR6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLR6
    QuantiTect SYBR Green Assays in human, mouse, rat TLR6
    QuantiFast Probe-based Assays in human, mouse, rat TLR6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TLR6 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr61 , 5 toll-like receptor 61, 5 77.74(n)1
    73.96(a)1
      5 (33.54 cM)5
    218991  NM_011604.31  NP_035734.31 
     649530955 
    chicken
    (Gallus gallus)
    Aves TLR1LB1 toll-like receptor 1-like B 60.84(n)
    54.02(a)
      771173  NM_001081709.3  NP_001075178.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Toll-like receptor
    49(a)
    48(a)
    many ↔ many
    many ↔ many
    GL343361.1(162095-164458)
    GL343361.1(130910-133312)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004939461 toll-like receptor 6-like 55.72(n)
    47.97(a)
      100493946  XM_004910930.1  XP_004910987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tlr16
    toll-like receptor 1
    34(a)
    1 → many
    14(733852-738712) ENSDARG00000043032
    fruit fly
    (Drosophila melanogaster)
    Insecta Toll-96
    Toll-9
    18(a)
    1 → many
    3L(20354943-20359824)


    ENSEMBL Gene Tree for TLR6 (if available)
    TreeFam Gene Tree for TLR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TLR6 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR92  TLR52  TLR102  TLR42  
    TLR82  TLR32  TLR22  
    3 SIMAP similar genes for TLR6 using alignment to 17 protein entries:     TLR6_HUMAN (see all proteins):
    TLR1    TLR10    TLR2

    Find genes that share paralogs with TLR6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TLR6 (see all 1013)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378531831,2,,4
    C,Funtested138720441(-) GTCCAG/CAGTGA 2 /H /Q mis11Minor allele frequency- C:0.00NA 4552
    rs1378531821,2
    Cuntested138721240(-) TACTGA/CCTCTG 2 D A mis10--------
    rs1378531791,2
    Cuntested138721937(-) TATTCA/GCTATC 2 T A mis10--------
    rs1378531781,2,,4
    Cuntested138722183(-) TAGATC/GTCTCA 2 L V mis10--------
    rs1468387191,2
    C--38150076(+) GCCCC-/ACCCCT 1 -- ut310--------
    rs672821581,2
    C--38151999(+) CCCTC-/CATCC 
            
    GGACT
    1 -- ut310--------
    rs2004625171,2
    --38152000(+) CCCTC-/GGACTCC 1 -- ut310--------
    rs456099361,2
    C--38152001(-) GGAGTA/C/TCGAGG 2 -- ut310--------
    rs2011043241,2
    C--38157013(+) ACAGG-/AAAAAA 1 -- int10--------
    rs58576441,2
    C--38170671(+) ATGAG-/AAAATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TLR6 (38825325 - 38858438 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TLR6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672127CNV Deletion23128226
    dgv5526n71CNV Loss21882294
    nsv818227CNV Gain17921354

    Human Gene Mutation Database (HGMD): TLR6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR6
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605403    OMIM disorders: --

    4 diseases for TLR6:    
    About MalaCards
    invasive aspergillosis    oral cavity cancer    pelvic inflammatory disease    asthma


    Find genes that share disorders with TLR6           About GenesLikeMe

    4 Novoseek inferred disease relationships for TLR6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 40.2 4 19019962 (1), 19117515 (1), 18424724 (1), 18159247 (1)
    necrosis 14.9 5 19621822 (1), 19019963 (1), 16960116 (1), 17714490 (1) (see all 5)
    asthma 12.1 5 15266299 (1), 18547625 (1), 16629799 (1), 16505608 (1)
    tumors 0 4 19621822 (1), 19019963 (1), 16960116 (1), 14585198 (1)

    Genetic Association Database (GAD): TLR6
    Human Genome Epidemiology (HuGE) Navigator: TLR6 (57 documents)

    Export disorders for TLR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TLR6 gene, integrated from 10 sources (see all 208):
    (articles sorted by number of sources associating them with TLR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TLR6: a novel member of an expanding Toll-like receptor family. (PubMed id 10231569)1, 2, 3, 9 Takeuchi O.... Akira S. (Gene 1999)
    2. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. (PubMed id 15266299)1, 4, 9 Tantisira K....Weiss S.T. (Genes Immun. 2004)
    3. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. (PubMed id 16461792)1, 4, 9 Kesh S....Papanicolaou G.A. (Ann. N. Y. Acad. Sci. 2005)
    4. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. (PubMed id 11441107)1, 2, 9 Bulut Y.... Arditi M. (J. Immunol. 2001)
    5. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (PubMed id 19771452)1, 4, 9 Velez D.R....Scott W.K. (Hum. Genet. 2010)
    6. Toll-like receptor heterodimer variants protect from childhood asthma. (PubMed id 18547625)1, 4, 9 Kormann M.S....Kabesch M. (J. Allergy Clin. Immunol. 2008)
    7. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. (PubMed id 17595233)1, 4, 9 Henckaerts L....Vermeire S. (Gut 2007)
    8. Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease. (PubMed id 16188043)1, 4, 9 Hoffjan S....Epplen J.T. (BMC Med. Genet. 2005)
    9. Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PubMed id 19200604)1, 4, 9 Verstraelen H....Temmerman M. (J. Reprod. Immunol. 2009)
    10. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. (PubMed id 18752252)1, 4, 9 Stevens V.L....Rodriguez C. (Int. J. Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10333 HGNC: 16711 AceView: TLR6 Ensembl:ENSG00000174130 euGenes: HUgn10333
    ECgene: TLR6 Kegg: 10333 H-InvDB: TLR6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TLR6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TLR6 gene:
    Search GeneIP for patents involving TLR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TLR6
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for TLR6 (TLR6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for TLR6 (TLR6)   Browse Stem Cell Products  
     cDNA Clones for TLR6 (TLR6)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TLR6   OriGene RNAi products in human, mouse, rat for TLR6  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TLR6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TLR6  
     OriGene qSTAR qPCR primer pairs in human, mouse for TLR6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TLR6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TLR6   OriGene Custom Protein Services for TLR6  

     
     
     Block miRNA regulation of human, mouse, rat TLR6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TLR6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR6 Predesigned siRNA for gene silencing in human, mouse, rat TLR6
     QuantiFast Probe-based Assays in human, mouse, rat TLR6 QuantiTect SYBR Green Assays in human, mouse, rat TLR6
     PCR Arrays including human, mouse, rat TLR6 Search Chromatin IP Primers for TLR6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLR6  GeneGlobe Interaction Network for TLR6
     Regulatory tfbs in TLR6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TLR6 GenScript cDNA clones with any tag delivered in your preferred vector for TLR6
     GenScript Custom Assay Services for TLR6 GenScript Custom overexpressing Cell Line Services for TLR6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for TLR6 

     Tocris compounds for TLR6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TLR6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for TLR6
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TLR6 antibodies
     TLR6 proteins
     TLR6 lysates
     Antibodies for TLR6
     See all of Abcam's Antibodies, Kits and Proteins for TLR6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TLR6
     Antibodies for TLR6
     ELISAs for TLR6
     CLIAs for TLR6



     Browse ESI BIO Cell Lines and PureStem Progenitors for TLR6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR6
     SwitchGear 3'UTR luciferase reporter plasmids for TLR6
     SwitchGear Promoter luciferase reporter plasmids for TLR6
     ThermoFisher Antibody for TLR6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLR6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLR6
     LSBio Antibodies in human, mouse, rat for TLR6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for TLR6
      Search eBioscience for proteins for TLR6
      Search eBioscience for elisas for TLR6
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TLR6 gene at Home site.
    Version: 3.12.216 30 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4