Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLR6 Gene

Aliases for TLR6 Gene

  • Toll-Like Receptor 6 2 3
  • CD286 Antigen 4
  • CD286 3

External Ids for TLR6 Gene

Summaries for TLR6 Gene

Entrez Gene Summary for TLR6 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

GeneCards Summary for TLR6 Gene

TLR6 (Toll-Like Receptor 6) is a Protein Coding gene. Diseases associated with TLR6 include invasive aspergillosis and asthma. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is CD180.

UniProtKB/Swiss-Prot for TLR6 Gene

  • Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Tocris Summary for TLR6 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like receptors are activated by molecules associated with biological threat and are highly specific towards evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR6 Gene

Genomics for TLR6 Gene

Genomic Location for TLR6 Gene

Start:
38,823,704 bp from pter
End:
38,856,817 bp from pter
Size:
33,114 bases
Orientation:
Minus strand

Genomic View for TLR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR6 Gene

Regulatory Elements for TLR6 Gene

Proteins for TLR6 Gene

  • Protein details for TLR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2C9-TLR6_HUMAN
    Recommended name:
    Toll-like receptor 6
    Protein Accession:
    Q9Y2C9
    Secondary Accessions:
    • B3Y640
    • B6CH35
    • B6RFS4
    • B6RFS5
    • Q2NKL3

    Protein attributes for TLR6 Gene

    Size:
    796 amino acids
    Molecular mass:
    91880 Da
    Quaternary structure:
    • Binds MYD88 via their respective TIR domains. Heterodimer with TLR2 via their respective extracellular domains (By similarity). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR4. The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

    Three dimensional structures from OCA and Proteopedia for TLR6 Gene

    Alternative splice isoforms for TLR6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR6 Gene

Proteomics data for TLR6 Gene at MOPED

Post-translational modifications for TLR6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn144, Asn186, Asn214, Asn253, Asn285, Asn359, Asn423, Asn434, and Asn583

Other Protein References for TLR6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TLR6 Gene

Domains for TLR6 Gene

Gene Families for TLR6 Gene

HGNC:
  • CD :CD molecules
IUPHAR :

UniProtKB/Swiss-Prot:

TLR6_HUMAN
Domain:
  • Contains 1 LRRCT domain.:
    • Q9Y2C9
  • Contains 1 TIR domain.:
    • Q9Y2C9
Family:
  • Belongs to the Toll-like receptor family.:
    • Q9Y2C9
Similarity:
  • Contains 19 LRR (leucine-rich) repeats.:
    • Q9Y2C9
genes like me logo Genes that share domains with TLR6: view

Function for TLR6 Gene

Molecular function for TLR6 Gene

GENATLAS Biochemistry: Drosophila transmembrane receptor Toll homolog 6,predominantly expressed in spleen,thymus,ovary and lung
UniProtKB/Swiss-Prot Function: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene Ontology (GO) - Molecular Function for TLR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10426995
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding --
GO:0042498 diacyl lipopeptide binding IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TLR6: view
genes like me logo Genes that share phenotypes with TLR6: view

Animal Models for TLR6 Gene

MGI Knock Outs for TLR6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TLR6 Gene

Localization for TLR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR6 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Note=Upon complex formation with CD36 and TLR4, internalized through dynamin-dependent endocytosis. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR6 Gene COMPARTMENTS Subcellular localization image for TLR6 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10231569
GO:0016021 integral component of membrane --
GO:0030670 phagocytic vesicle membrane IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with TLR6: view

Pathways for TLR6 Gene

genes like me logo Genes that share pathways with TLR6: view

Pathways by source for TLR6 Gene

Gene Ontology (GO) - Biological Process for TLR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 10426995
GO:0007165 signal transduction TAS 10231569
genes like me logo Genes that share ontologies with TLR6: view

Compounds for TLR6 Gene

(5) Tocris Compounds for TLR6 Gene

Compound Action Cas Number
Imiquimod Toll-like receptor 7 (TLR7) agonist [99011-02-6]
Pam2CSK4 TLR2/6 agonist; induces TNF-alpha production [868247-72-7]
Pam3CSK4 TLR1/2 agonist; induces cytokine production [112208-00-1]
Poly(I:C) TLR3 agonist [42424-50-0]
Resiquimod Toll-like receptor 7 (TLR7) agonist [144875-48-9]

(4) Novoseek inferred chemical compound relationships for TLR6 Gene

Compound -log(P) Hits PubMed IDs
peptidoglycan 66.9 10
flagellin 55.1 1
rantes 16.4 2
lipid 0 1
genes like me logo Genes that share compounds with TLR6: view

Transcripts for TLR6 Gene

mRNA/cDNA for TLR6 Gene

Unigene Clusters for TLR6 Gene

Toll-like receptor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR6 Gene

No ASD Table

Relevant External Links for TLR6 Gene

GeneLoc Exon Structure for
TLR6
ECgene alternative splicing isoforms for
TLR6

Expression for TLR6 Gene

mRNA expression in normal human tissues for TLR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR6 Gene

This gene is overexpressed in Whole Blood (20.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLR6 Gene

SOURCE GeneReport for Unigene cluster for TLR6 Gene Hs.575090

mRNA Expression by UniProt/SwissProt for TLR6 Gene

Q9Y2C9-TLR6_HUMAN
Tissue specificity: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells
genes like me logo Genes that share expressions with TLR6: view

Orthologs for TLR6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR6 36
  • 98.79 (n)
  • 98.12 (a)
TLR6 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLR6 36
  • 85.25 (n)
  • 79.59 (a)
TLR6 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR6 36
  • 84.59 (n)
  • 77.14 (a)
TLR6 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr6 36
  • 77.74 (n)
  • 73.96 (a)
Tlr6 16
Tlr6 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tlr6 36
  • 77.86 (n)
  • 74.34 (a)
chicken
(Gallus gallus)
Aves TLR1LA 37
  • 47 (a)
ManyToMany
TLR1LB 36
  • 60.84 (n)
  • 54.02 (a)
TLR1LB 37
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 48 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493946 36
  • 55.72 (n)
  • 47.97 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr1 37
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 37
  • 18 (a)
OneToMany
Species with no ortholog for TLR6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR6 Gene

ENSEMBL:
Gene Tree for TLR6 (if available)
TreeFam:
Gene Tree for TLR6 (if available)

Paralogs for TLR6 Gene

Paralogs for TLR6 Gene

genes like me logo Genes that share paralogs with TLR6: view

Variants for TLR6 Gene

Sequence variations from dbSNP and Humsavar for TLR6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs167251 -- 38,830,871(-) ACGTA(A/G)AGCAA intron-variant
rs184184 -- 38,830,772(-) CTCTA(A/G)AAATC intron-variant
rs188489 -- 38,830,966(-) AATTA(A/G)AGATT intron-variant
rs190953 -- 38,848,279(-) gtaca(A/G)atggg intron-variant
rs190954 -- 38,842,805(-) tcttc(G/T)aaatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLR6 Gene

Variant ID Type Subtype PubMed ID
dgv5526n71 CNV Loss 21882294
esv2672127 CNV Deletion 23128226
nsv818227 CNV Gain 17921354

Relevant External Links for TLR6 Gene

HapMap Linkage Disequilibrium report
TLR6
Human Gene Mutation Database (HGMD)
TLR6

Disorders for TLR6 Gene

(4) Novoseek inferred disease relationships for TLR6 Gene

Disease -log(P) Hits PubMed IDs
inflammation 40.2 4
necrosis 14.9 5
asthma 12.1 4
tumors 0 4

Relevant External Links for TLR6

Genetic Association Database (GAD)
TLR6
Human Genome Epidemiology (HuGE) Navigator
TLR6
genes like me logo Genes that share disorders with TLR6: view

No data available for UniProtKB/Swiss-Prot for TLR6 Gene

Publications for TLR6 Gene

  1. TLR6: a novel member of an expanding Toll-like receptor family. (PMID: 10231569) Takeuchi O. … Akira S. (Gene 1999) 2 3 4 23
  2. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. (PMID: 11441107) Bulut Y. … Arditi M. (J. Immunol. 2001) 3 4 23
  3. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. (PMID: 15266299) Tantisira K. … Weiss S.T. (Genes Immun. 2004) 3 23 49
  4. Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease. (PMID: 16188043) Hoffjan S. … Epplen J.T. (BMC Med. Genet. 2005) 3 23 49
  5. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. (PMID: 16461792) Kesh S. … Papanicolaou G.A. (Ann. N. Y. Acad. Sci. 2005) 3 23 49

Products for TLR6 Gene

  • Addgene plasmids for TLR6

Sources for TLR6 Gene

Back to Top

Content