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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TLR5 Gene

protein-coding GIFtS: 66
GCID: GC01M223283

toll-like receptor 5

Explore 53 diseases affiliated with
TLR5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Toll-Like Receptor 5¹ ²		FLJ10052¹
TIL3¹ ² ³ ⁵		MGC126430¹
SLEB1¹ ² ⁵		MGC126431¹
Toll/Interleukin-1 Receptor-Like Protein 3² ³

External Ids:	HGNC: 11851¹	Entrez Gene: 7100²	Ensembl: ENSG00000187554⁷	OMIM: 603031⁵	UniProtKB: O60602³

Export aliases for TLR5 gene to outside databases

Previous GC identifers: GC01M221867 GC01M219203 GC01M9A0154 GC01M9A1397 GC01M9A1373 GC01M8T1373 GC01M221350 GC01M193957

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR5:

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen

recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated

molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial

flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor

mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations

in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and

susceptibility to Legionnaire disease.(provided by RefSeq, Dec 2009)

UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602

Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins.

Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

Gene Wiki entry for TLR5 (TLR 5)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TLR5 gene promoter:
LHX3b/Lhx3b Sp1 AP-1 ATF-2 Ik-3 LHX3a/Lhx3a Cart-1 c-Jun NF-kappaB1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TLR5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41-q42 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q32.3-q42

TLR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M223283: view genomic region (about GC identifiers)

Start:	223,282,748 bp from pter	End:	223,316,624 bp from pter
Size:	33,877 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602 (See protein sequence)

Recommended Name: Toll-like receptor 5 precursor

Size: 858 amino acids; 97834 Da

Subunit: Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of

ligand

Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)

2 PDB 3D structures from and Proteopedia for TLR5:

1P95 (3D)

3J0A (3D)

Secondary accessions: B1AZ05 B3Y633 D3DTB8 O15456 Q32MI3

Explore the universe of human proteins at neXtProt for TLR5: NX_O60602

Post-translational modifications:

Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines¹

Phosphorylated at Tyr-798 upon flagellin binding; required for signaling¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60602

TLR5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003259.2

ENSEMBL proteins:

ENSP00000355846 ENSP00000385458 ENSP00000440643 ENSP00000340089

Reactome Protein details: O60602
Human Recombinant Protein Products:

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	Novus Biologicals TLR5 Proteins Novus Biologicals TLR5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TLR5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

TLR5 for ontologies About GeneDecksing

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	ThermoFisher Antibody for TLR5

Assay Products for TLR5:

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	GenScript Custom Assay Services for TLR5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TLR5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TLR5 for domains About GeneDecksing

5 InterPro domains/families:

IPR000483 Cys-rich_flank_reg_C

IPR001611 Leu-rich_rpt

IPR000157 TIR_dom

IPR003591 Leu-rich_rpt_typical-subtyp

IPR027176 TLR5

Graphical View of Domain Structure for InterPro Entry O60602

ProtoNet protein and cluster: O60602

3 Blocks protein families:

IPB000157 TIR domain

IPB000483 Cysteine-rich flanking region

IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602

Similarity: Belongs to the Toll-like receptor family

Similarity: Contains 15 LRR (leucine-rich) repeats

Similarity: Contains 1 TIR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602

Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins.

Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

Genatlas biochemistry entry for TLR5:

Drosophila transmembrane receptor Toll homolog 5,specifically expressed in ovary and peripheral monocytes

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		hsa-miR-150
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR5 (see all 6) OriGene siRNA: TLR5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TLR5

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR5

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005149	interleukin-1 receptor binding	IPI	12925853

TLR5 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TLR5:

Decreased number of cells in m

Animal Models:
Mouse knock-outs for TLR5: Tlr5^tm1Flv Tlr5^tm1Aki
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tlr5):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
liver/biliary system	respiratory system

TLR5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Toll-like receptor signaling pathway

	Toll-like receptor signaling pathway	1.00			Toll-Like receptor Signaling Pathways	0.51
	Toll-like receptor signaling pathway	0.97			Inflammasome Activation Pathways	0.29

TRAF6 Mediated Induction of proinflammatory cytokines

	Toll Like Receptor 10 (TLR10) Cascade	0.86			MyD88 cascade initiated on plasma membrane	0.86
	Toll Like Receptor 5 (TLR5) Cascade	0.86			Toll-Like Receptors Cascades	0.53

Immune response_Bacterial infections in normal airways

Immune response_Bacterial infections in normal airways

1.00

Bacterial infections in CF airways

0.78

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

1.00

Mucin expression in CF via TLRs, EGFR signaling pathways

0.41

Immune System

Immune System

1.00

Innate Immune System

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TLR5

Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

5 R&D Systems Pathways for TLR5

	Inflammasome Activation Pathways
	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways
	Th17 Differentiation

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR5 (see all 8)

	NF-KappaB (p50-p65) Pathway
	Toll-Like Receptors Pathway
	TRAF Pathway
	TREM1 Pathway
	Colorectal Cancer Metastasis

1 Tocris Bioscience Pathway for TLR5

Toll-like Receptor Pathway

5 GeneGo (Thomson Reuters) Pathways for TLR5

	Mucin expression in CF via TLRs, EGFR signaling pathways
	Immune response Bacterial infections in normal airways
	Immune response TLR signaling pathways
	Bacterial infections in CF airways
	Mucin expression in CF via IL-6, IL-17 signaling pathways

2 BioSystems Pathways for TLR5

	Toll-like receptor signaling pathway
	Pathogenic Escherichia coli infection

5/6 Reactome Pathways for TLR5 (see all 6)

	Toll-Like Receptors Cascades
	Toll Like Receptor 5 (TLR5) Cascade
	MyD88 cascade initiated on plasma membrane
	Toll Like Receptor 10 (TLR10) Cascade
	Immune System

2 Kegg Pathways (Kegg details for TLR5):

	Toll-like receptor signaling pathway
	Pathogenic Escherichia coli infection

TLR5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TLR5

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/12 Interacting proteins for TLR5 (O60602^{2, 3} ENSP00000340089⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYD88	Q99836²^,³, ENSP00000379625⁴	MINT-4950414 I2D: score=4 STRING: ENSP00000379625
SIGIRR	Q6IA17³, ENSP00000333656⁴	I2D: score=1 STRING: ENSP00000333656
TLR1	Q15399³, ENSP00000354932⁴	I2D: score=1 STRING: ENSP00000354932
TLR4	O00206³, ENSP00000363089⁴	I2D: score=2 STRING: ENSP00000363089
RNF216	Q9NWF9³, ENSP00000374552⁴	I2D: score=2 STRING: ENSP00000374552

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--
GO:0006954	inflammatory response	IEA	--
GO:0032757	positive regulation of interleukin-8 production	IDA	17128265
GO:0034123	positive regulation of toll-like receptor signaling pathway	IDA	17128265
GO:0045087	innate immune response	TAS	--

TLR5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TLR5 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TLR5
10 Novoseek chemical compound relationships for TLR5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
flagellin	96.4	252	12711596 (8), 17964652 (6), 20164175 (6), 19774646 (5) (see all 99)
loxoribine	80.7	2	15749901 (1), 15804290 (1)
lipoteichoic acid	74	11	19267841 (1), 15090474 (1), 16239509 (1), 18571707 (1) (see all 6)
poly(i-c)	72.3	2	16365459 (1), 17202379 (1)
peptidoglycan	67.3	13	16365459 (1), 16982839 (1), 14996826 (1), 15090474 (1) (see all 10)
asialo gm1	56.5	13	17065492 (5), 16439799 (4), 14607814 (3)
phosphatidylinositol	12.8	3	16644730 (2), 19740321 (1)
rantes	4.38	1	17250816 (1)
atp	0	1	16439799 (1)
tyrosine	0	1	16984412 (1)

Search CenterWatch for drugs/clinical trials and news about TLR5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TLR5 gene:

NM_003268.5

Unigene Cluster for TLR5:

Toll-like receptor 5

Hs.604542 [show with all ESTs]

Unigene Representative Sequence: NM_003268

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366881 ENST00000407096 ENST00000484766 ENST00000465726 ENST00000540964(uc001hnv.2 uc001hnw.2)

ENST00000342210

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLR5
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TLR5:
		hsa-miR-150
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		GenScript: all cDNA clones in your preferred vector: TLR5 (NM_003268)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR5

Additional cDNA sequence:

AB060695.1 AB445645.1 AF051151.1 BC109118.1 BC109119.1 U88881.1

4 DOTS entries:

DT.206807 DT.95334044 DT.65287368 DT.121386557

24/29 AceView cDNA sequences (see all 29):

BX431083 AI628028 AI628024 BV190535 N47123 BX112000 BX431084 BE742505

BV205068 BQ448631 AB060695 AF051151 N41021 AI672306 BX498540 NM_003268

AW612654 AW295464 CB988553 BF915016 AV691850 BX441259 U88881 AW470630

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TLR5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGTCTCA

About this image

TLR5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Umbilical Veins

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TLR5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLR5

SOURCE GeneReport for Unigene cluster: Hs.604542

UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602

Tissue specificity: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in

CD11c+ immature dendritic cells. Also detected in prostate and testis

SABiosciences Expression via Pathway-Focused PCR Arrays including TLR5 (see all 6):

Innate & Adaptive Immune Responses in human mouse rat

Toll-Like Receptor Signaling Pathway in human mouse rat

Lymphoma in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TLR5 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TLR5¹	toll-like receptor 5	59.83(n) 52.29(a)		554217 NM_001024586.1 NP_001019757.1
lizard (Anolis carolinensis)	Reptilia	TLR5⁶ --	--	50(a) 33(a)	1 ↔ 1 possible ortholog	1(244701050-244703690) GL344221.1(22830-25355)
zebrafish (Danio rerio)	Actinopterygii	tlr5b¹	toll-like receptor 5b	47.19(n) 38.8(a)		403139 NM_001130595.1 NP_001124067.1
fruit fly (Drosophila melanogaster)	Insecta	Tehao⁶ MstProx⁶ (see all 4)	MstProx (see all 4)	15(a) 13(a) (see all 4)	possible ortholog possible ortholog (see all 4)	2L(13435622-13439333) 3R(3191661-3195027)

ENSEMBL Gene Tree for TLR5 (if available)
TreeFam Gene Tree for TLR5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TLR5 gene

CD180² ENSG00000173366² TLR7² TLR1² TLR9² TLR10² LRRC33² TLR4²

TLR8² TLR6² LRRC32² TLR3² TLR2²

TLR5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602

Polymorphism: Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin

signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by

Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201906412^1,2	C	other	193960419(+)	`CAAGCG/AAGTTA`	2	/R /C	mis¹		1		EU	1321
rs202142812^1,2	C	--	193956791(+)	`AAACGA/TAGAAA`	1	--	ds500¹		0	--	--	--	--
rs78478695^1,2		--	193957033(+)	`GGGAAA/GAAGGT`	1	--	ds500¹		0	--	--	--	--
rs5744193^1,2	C	--	193957099(-)	`ACTCCA/CGNNNN`	1	--	ds500¹		3		NA EU	94
rs5744192^1,2	C	--	193957107(-)	`CCAGCG/ATAACT`	1	--	ds500¹		3		NA EU	94
rs5744191^1,2	C,	--	193957294(-)	`GGCAGT/ATGCAA`	1	--	ut3¹		3		NA EU	94
rs5744188^1,2	C,F,	--	193957338(-)	`CCTAAT/CGACCA`	1	--	ut3¹		6		NA EU WA CSA	216
rs76220310^1,2	C,	--	193957349(+)	`GCAACG/AAAGGA`	1	--	ut3¹		2		WA	120
rs5744187^1,2	C,	--	193957568(-)	`AGCACA/GCCTCA`	1	--	ut3¹		4		NA EU WA	212
rs5744186^1,2	C,	--	193957569(-)	`TAGCAC/TACCTC`	1	--	ut3¹		4		NA EU WA	212

HapMap Linkage Disequilibrium report for TLR5 (223282748 - 223316624 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TLR5: --
Human Gene Mutation Database (HGMD): TLR5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR5

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TLR5 for disorders           About GeneDecksing

OMIM gene information: 603031
OMIM disorders: 608556  601744
UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602

Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1)

[MIM:601744]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is

an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by

involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the

regulatory mechanisms of the autoimmune system

20/53 diseases for TLR5 (see all 53): About MalaCards

systemic lupus erythematosus lupus erythematosus legionnaires' disease legionaire disease

systemic lupus erythematosus, resistance to inflammatory bowel disease lemierres syndrome lemierre's syndrome

primary biliary cirrhosis typhoid fever bronchiolitis obliterans cystic fibrosis lung disease

chronic granulomatous disease myocardial infarction oral squamous cell carcinoma acute myocardial infarction

cystic fibrosis squamous cell carcinoma septic arthritis gastroenteritis

2 diseases from the University of Copenhagen DISEASES database for TLR5:

Influenza Inflammatory bowel disease

10/15 Novoseek disease relationships for TLR5 gene (see all 15) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	42.4	3	12185085 (1), 14688376 (1), 19596770 (1)
inflammatory bowel diseases	37.2	1	16439468 (1)
colitis ulcerative	36.5	1	20083854 (1)
colitis	35.8	5	19774646 (3)
legionnaires disease	34.7	2	14623910 (1), 15747241 (1)
pouchitis	31.5	1	16770571 (1)
pneumonia	25.3	3	18490781 (1), 14623910 (1)
necrosis	19.8	6	18538140 (2), 19267841 (1), 16903774 (1), 16960116 (1)
bacterial infections	19.6	3	15339910 (1)
sepsis	11.2	1	15794413 (1)

Genetic Association Database (GAD): TLR5
Human Genome Epidemiology (HuGE) Navigator: TLR5 (42 documents)

Export disorders for TLR5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TLR5 gene, integrated from 9 sources (see all 322):
(articles sorted by number of sources associating them with TLR5)

Utopia: connect your pdf to the dynamic
world of online information

A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. (PubMed id 16027372)^{1, 2, 4, 9} Hawn T.R.... Aderem A. (2005)
A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)^{1, 2, 3, 9} Rock F.L.... Bazan J.F. (1998)
Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. (PubMed id 17442957)^{1, 2, 9} Ivison S.M....Steiner T.S. (2007)
Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. (PubMed id 15747241)^{1, 4, 9} Dunstan S.J....Farrar J.J. (2005)
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. (PubMed id 9596645)^{1, 2, 9} Chaudhary P.M.... Nelson P.S. (1998)
A history of recurrent positive selection at the toll-like receptor 5 in primates. (PubMed id 19179655)^{1, 2, 9} Wlasiuk G.... Nachman M.W. (2009)
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. (PubMed id 14623910)^{1, 2, 9} Hawn T.R.... Aderem A. (2003)
The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk. (PubMed id 16284379)^{1, 4, 9} Xu J....Gronberg H. (2005)
Toll-like receptor 5 forms asymmetric dimers in the ab sence of flagellin. (PubMed id 22173220)^{1, 2} Zhou K....Modis Y. (2012)
Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)^{1, 2} Nakajima T....Kimura A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7100	HGNC: 11851	AceView: TLR5	Ensembl:ENSG00000187554	euGenes: HUgn7100
ECgene: TLR5	Kegg: 7100	H-InvDB: TLR5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TLR5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TLR5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TLR5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TLR5 gene:
Search GeneIP for patents involving TLR5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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