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Aliases for TLR5 Gene

Aliases for TLR5 Gene

  • Toll-Like Receptor 5 2 3
  • Toll/Interleukin-1 Receptor-Like Protein 3 2 3 4
  • TIL3 3 4 6
  • Systemic Lupus Erythematosus Susceptibility 1 2 3
  • MELIOS 3 6
  • SLEB1 3 6
  • SLE1 3

External Ids for TLR5 Gene

Previous HGNC Symbols for TLR5 Gene

  • SLEB1

Previous GeneCards Identifiers for TLR5 Gene

  • GC01M221867
  • GC01M219203
  • GC01M9A0154
  • GC01M9A1397
  • GC01M9A1373
  • GC01M8T1373
  • GC01M221350
  • GC01M223283
  • GC01M193957

Summaries for TLR5 Gene

Entrez Gene Summary for TLR5 Gene

  • This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

GeneCards Summary for TLR5 Gene

TLR5 (Toll-Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include systemic lupus erythematosus 1 and legionellosis. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include interleukin-1 receptor binding. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR5 Gene

  • Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Wiki entry for TLR5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR5 Gene

Genomics for TLR5 Gene

Regulatory Elements for TLR5 Gene

Genomic Location for TLR5 Gene

Start:
223,109,406 bp from pter
End:
223,143,282 bp from pter
Size:
33,877 bases
Orientation:
Minus strand

Genomic View for TLR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR5 Gene

Proteins for TLR5 Gene

  • Protein details for TLR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60602-TLR5_HUMAN
    Recommended name:
    Toll-like receptor 5
    Protein Accession:
    O60602
    Secondary Accessions:
    • B1AZ05
    • B3Y633
    • B9VJ63
    • D1CS80
    • D3DTB8
    • O15456
    • Q32MI2
    • Q32MI3

    Protein attributes for TLR5 Gene

    Size:
    858 amino acids
    Molecular mass:
    97834 Da
    Quaternary structure:
    • Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand.

    Three dimensional structures from OCA and Proteopedia for TLR5 Gene

neXtProt entry for TLR5 Gene

Proteomics data for TLR5 Gene at MOPED

Post-translational modifications for TLR5 Gene

  • Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
  • Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • Glycosylation at Asn37, Asn46, Asn245, Asn342, Asn422, Asn595, and Asn598
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TLR5 Gene

Domains for TLR5 Gene

Gene Families for TLR5 Gene

Graphical View of Domain Structure for InterPro Entry

O60602

UniProtKB/Swiss-Prot:

TLR5_HUMAN :
  • O60602
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 22 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR5: view

Function for TLR5 Gene

Molecular function for TLR5 Gene

GENATLAS Biochemistry: Drosophila transmembrane receptor Toll homolog 5,specifically expressed in ovary and peripheral monocytes
UniProtKB/Swiss-Prot Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Gene Ontology (GO) - Molecular Function for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005149 interleukin-1 receptor binding IPI 12925853
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TLR5: view
genes like me logo Genes that share phenotypes with TLR5: view

Animal Models for TLR5 Gene

MGI Knock Outs for TLR5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TLR5 Gene

Localization for TLR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR5 Gene COMPARTMENTS Subcellular localization image for TLR5 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLR5: view

Pathways for TLR5 Gene

genes like me logo Genes that share pathways with TLR5: view

Interacting Proteins for TLR5 Gene

Gene Ontology (GO) - Biological Process for TLR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction --
GO:0008584 male gonad development IEA --
genes like me logo Genes that share ontologies with TLR5: view

Compounds for TLR5 Gene

(1) IUPHAR Ligand for TLR5 Gene

Ligand Type Action Affinity Pubmed IDs
flagellin Agonist Agonist

(10) Novoseek inferred chemical compound relationships for TLR5 Gene

Compound -log(P) Hits PubMed IDs
flagellin 96.4 178
loxoribine 80.7 2
lipoteichoic acid 74 6
poly(i-c) 72.3 2
peptidoglycan 67.3 10
genes like me logo Genes that share compounds with TLR5: view

Transcripts for TLR5 Gene

Unigene Clusters for TLR5 Gene

Toll-like receptor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR5 Gene

No ASD Table

Relevant External Links for TLR5 Gene

GeneLoc Exon Structure for
TLR5
ECgene alternative splicing isoforms for
TLR5

Expression for TLR5 Gene

mRNA expression in normal human tissues for TLR5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR5 Gene

This gene is overexpressed in Whole Blood (20.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TLR5 Gene

SOURCE GeneReport for Unigene cluster for TLR5 Gene Hs.604542

mRNA Expression by UniProt/SwissProt for TLR5 Gene

O60602-TLR5_HUMAN
Tissue specificity: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis
genes like me logo Genes that share expressions with TLR5: view

Orthologs for TLR5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR5 35
  • 99.18 (n)
  • 98.6 (a)
cow
(Bos Taurus)
Mammalia TLR5 35
  • 83.26 (n)
  • 79.14 (a)
TLR5 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR5 35
  • 67.71 (n)
  • 65.75 (a)
TLR5 36
  • 39 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr5 35
  • 76.07 (n)
  • 72.49 (a)
Tlr5 16
Tlr5 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLR5 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLR5 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr5 35
  • 75.14 (n)
  • 70.28 (a)
chicken
(Gallus gallus)
Aves TLR5 35
  • 59.8 (n)
  • 52.22 (a)
TLR5 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLR5 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496647 35
  • 54.13 (n)
  • 47.71 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr5a 36
  • 35 (a)
OneToMany
tlr5b 35
  • 47.15 (n)
  • 39.04 (a)
tlr5b 36
  • 37 (a)
OneToMany
Species with no ortholog for TLR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR5 Gene

ENSEMBL:
Gene Tree for TLR5 (if available)
TreeFam:
Gene Tree for TLR5 (if available)

Paralogs for TLR5 Gene

Paralogs for TLR5 Gene

genes like me logo Genes that share paralogs with TLR5: view

Variants for TLR5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR5 Gene

O60602-TLR5_HUMAN
A nonsense TLR5 polymorphism, resulting in p.Arg392Ter, confers resistance to melioidosis [MIM:615557], an infection caused by the Gram-negative, flagellated soil saprophyte Burkholderia pseudomallei. Carriers of this hypofunctional TLR5 variant may generate impaired inflammatory responses during melioidosis infection that result in reduced organ failure and lower mortality

Sequence variations from dbSNP and Humsavar for TLR5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs712866 -- 223,128,121(-) CATAC(A/G)GGCGA intron-variant
rs712867 -- 223,116,078(-) TAACA(C/T)GGCAG intron-variant
rs729586 -- 223,145,114(-) AAGTT(C/G)TCAGG upstream-variant-2KB
rs759303 -- 223,143,795(-) GAGGG(A/G)GTTAG upstream-variant-2KB
rs759304 -- 223,143,790(-) GGTTA(A/G)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TLR5 Gene

Variant ID Type Subtype PubMed ID
nsv873207 CNV Loss 21882294
esv1122523 CNV Insertion 17803354
nsv832659 CNV Gain 17160897

Relevant External Links for TLR5 Gene

HapMap Linkage Disequilibrium report
TLR5
Human Gene Mutation Database (HGMD)
TLR5

Disorders for TLR5 Gene

(3) OMIM Diseases for TLR5 Gene (603031)

UniProtKB/Swiss-Prot

TLR5_HUMAN
  • Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for TLR5 Gene

(15) Novoseek inferred disease relationships for TLR5 Gene

Disease -log(P) Hits PubMed IDs
inflammation 42.4 3
inflammatory bowel diseases 37.2 1
colitis ulcerative 36.5 1
colitis 35.8 3
legionnaires disease 34.7 2

Relevant External Links for TLR5

Genetic Association Database (GAD)
TLR5
Human Genome Epidemiology (HuGE) Navigator
TLR5
genes like me logo Genes that share disorders with TLR5: view

Publications for TLR5 Gene

  1. A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. (PMID: 16027372) Hawn T.R. … Aderem A. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 4 23 48
  2. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. (PMID: 16439468) Gewirtz A.T. … Cho J.H. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006) 3 23 48
  3. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. (PMID: 9596645) Chaudhary P.M. … Nelson P.S. (Blood 1998) 3 4 23
  4. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. (PMID: 14623910) Hawn T.R. … Aderem A. (J. Exp. Med. 2003) 3 4 23
  5. Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. (PMID: 15747241) Dunstan S.J. … Farrar J.J. (J. Infect. Dis. 2005) 3 23 48

Products for TLR5 Gene

  • Addgene plasmids for TLR5

Sources for TLR5 Gene

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