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TLR5 Gene

protein-coding   GIFtS: 68
GCID: GC01M223283

Toll-Like Receptor 5

(Previous name: systemic lupus erythematosus susceptibility 1)
(Previous symbol: SLEB1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Toll-Like Receptor 51 2
Toll/Interleukin-1 Receptor-Like Protein 31 2 3
SLEB11 2 5
TIL32 3 5
Systemic Lupus Erythematosus Susceptibility 11 2
MELIOS2 5

External Ids:    HGNC: 118511   Entrez Gene: 71002   Ensembl: ENSG000001875547   OMIM: 6030315   UniProtKB: O606023   

Export aliases for TLR5 gene to outside databases

Previous GC identifers: GC01M221867 GC01M219203 GC01M9A0154 GC01M9A1397 GC01M9A1373 GC01M8T1373 GC01M221350 GC01M193957


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLR5 Gene:
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen
recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated
molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial
flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor
mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes.
Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus
erythematosus, and susceptibility to Legionnaire disease.(provided by RefSeq, Dec 2009)

GeneCards Summary for TLR5 Gene:
TLR5 (toll-like receptor 5) is a protein-coding gene. Diseases associated with TLR5 include systemic lupus erythematosus, and lemierre's syndrome. GO annotations related to this gene include interleukin-1 receptor binding. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602
Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial
flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory
response

Gene Wiki entry for TLR5 (TLR 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLR5 gene promoter:
         LHX3b/Lhx3b   Sp1   AP-1   ATF-2   Ik-3   LHX3a/Lhx3a   Cart-1   c-Jun   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TLR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41-q42   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q32.3-q42

TLR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M223283:  view genomic region     (about GC identifiers)

Start:
223,282,748 bp from pter      End:
223,316,624 bp from pter
Size:
33,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602 (See protein sequence)
Recommended Name: Toll-like receptor 5 precursor  
Size: 858 amino acids; 97834 Da
Subunit: Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence
of ligand
2 PDB 3D structures from and Proteopedia for TLR5:
1P95 (3D)        3J0A (3D)    
Secondary accessions: B1AZ05 B3Y633 B9VJ63 D1CS80 D3DTB8 O15456 Q32MI2 Q32MI3

Explore the universe of human proteins at neXtProt for TLR5: NX_O60602

Explore proteomics data for TLR5 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines1
  • Phosphorylated at Tyr-798 upon flagellin binding; required for signaling1
  • Glycosylation2 at Asn37, Asn46, Asn245, Asn342, Asn422, Asn595, Asn598
  • Modification sites at PhosphoSitePlus

  • See TLR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003259.2  
    ENSEMBL proteins: 
     ENSP00000355846   ENSP00000385458   ENSP00000440643   ENSP00000340089  
    Reactome Protein details: O60602

    TLR5 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TLR5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TLR5
    GenScript Custom Purified and Recombinant Proteins Services for TLR5
    Novus Biologicals TLR5 Proteins
    Novus Biologicals TLR5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR5

    TLR5 Antibody Products:

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    TLR5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TLR5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLR5
    Cloud-Clone Corp. CLIAs for TLR5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR5
    Toll-like receptor family

    4 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry O60602

    ProtoNet protein and cluster: O60602

    3 Blocks protein domains:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 15 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    TLR5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR5_HUMAN, O60602
    Function: Participates in the innate immune response to microbial agents. Mediates detection of bacterial
    flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory
    response

         Genatlas biochemistry entry for TLR5:
    Drosophila transmembrane receptor Toll homolog 5,specifically expressed in ovary and peripheral monocytes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005149interleukin-1 receptor binding IPI12925853
    GO:0005515protein binding ----
         
    TLR5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TLR5:
     Decreased number of cells in m 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tlr5):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  respiratory system 

    TLR5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TLR5: Tlr5tm1Flv Tlr5tm1Aki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLR5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLR5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR5

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    hsa-miR-150
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TLR5 (see all 7)
    OriGene ORF clones in mouse, rat for TLR5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLR5 (NM_003268)
    Sino Biological Human cDNA Clone for TLR5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR5

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLR5_HUMAN, O60602: Membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    TLR5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLR5 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    NOD-like Receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    4Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    5NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TLR5 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLR5 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Tocris Bioscience Pathway for TLR5
        Toll-like Receptor Pathway

    5 GeneGo (Thomson Reuters) Pathways for TLR5
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response TLR signaling pathways
    Bacterial infections in CF airways
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    3 BioSystems Pathways for TLR5
        Toll-like receptor signaling pathway
    Pathogenic Escherichia coli infection
    Regulation of toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR5
        NF-kB (NFkB) Pathway

    2 Reactome Pathways for TLR5
        Toll Like Receptor 5 (TLR5) Cascade
    MyD88 cascade initiated on plasma membrane


    5 Kegg Pathways  (Kegg details for TLR5):
        Toll-like receptor signaling pathway
    Pathogenic Escherichia coli infection
    Salmonella infection
    Legionellosis
    Inflammatory bowel disease (IBD)


    TLR5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR5 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for TLR5 (O606022, 3 ENSP000003400894) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYD88Q998362, 3, ENSP000003796254MINT-4950414 I2D: score=4 STRING: ENSP00000379625
    SIGIRRQ6IA173, ENSP000003336564I2D: score=1 STRING: ENSP00000333656
    TLR1Q153993, ENSP000003549324I2D: score=1 STRING: ENSP00000354932
    TLR4O002063, ENSP000003630894I2D: score=2 STRING: ENSP00000363089
    RNF216Q9NWF93, ENSP000003745524I2D: score=2 STRING: ENSP00000374552
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    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0006954inflammatory response IEA--
    GO:0007165signal transduction ----
    GO:0008584male gonad development IEA--

    TLR5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLR5

    1 IUPHAR Ligand for TLR5 (TLR5)    About this table
    LigandTypeActionAffinityPubmed IDs
    flagellin
    AgonistAgonist11323673

    10 Novoseek inferred chemical compound relationships for TLR5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flagellin 96.4 252 12711596 (8), 17964652 (6), 20164175 (6), 19774646 (5) (see all 99)
    loxoribine 80.7 2 15749901 (1), 15804290 (1)
    lipoteichoic acid 74 11 19267841 (1), 15090474 (1), 16239509 (1), 18571707 (1) (see all 6)
    poly(i-c) 72.3 2 16365459 (1), 17202379 (1)
    peptidoglycan 67.3 13 16365459 (1), 16982839 (1), 14996826 (1), 15090474 (1) (see all 10)
    asialo gm1 56.5 13 17065492 (5), 16439799 (4), 14607814 (3)
    phosphatidylinositol 12.8 3 16644730 (2), 19740321 (1)
    rantes 4.38 1 17250816 (1)
    atp 0 1 16439799 (1)
    tyrosine 0 1 16984412 (1)



    TLR5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TLR5 gene: 
    NM_003268.5  

    Unigene Cluster for TLR5:

    Toll-like receptor 5
    Hs.604542  [show with all ESTs]
    Unigene Representative Sequence: NM_003268
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366881 ENST00000407096 ENST00000484766 ENST00000465726 ENST00000540964(uc001hnv.2 uc001hnw.2)
    ENST00000342210
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLR5
      QuantiTect SYBR Green Assays in human, mouse, rat TLR5
      QuantiFast Probe-based Assays in human, mouse, rat TLR5

    Additional mRNA sequence: 

    AB060695.1 AB445645.1 AF051151.1 BC109118.1 BC109119.1 U88881.1 

    4 DOTS entries:

    DT.206807  DT.95334044  DT.65287368  DT.121386557 

    Selected AceView cDNA sequences (see all 29):

    AI628028 BX112000 BX431083 BV190535 N47123 AI628024 BQ448631 AW612654 
    BE742505 AF051151 AW295464 AI672306 CB988553 N41021 BX498540 BX431084 
    BV205068 NM_003268 AB060695 BX441259 U88881 BF915016 AV691850 AW193354 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLR5 expression in normal human tissues (normalized intensities)      TLR5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGTCTCA
    TLR5 Expression
    About this image


    TLR5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Veins
    TLR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.604542

    UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602
    Tissue specificity: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in
    CD11c+ immature dendritic cells. Also detected in prostate and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR5 (see all 6): 
              Innate & Adaptive Immune Responses in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Lymphoma in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TLR5 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr51 , 5 toll-like receptor 51, 5 76.07(n)1
    72.49(a)1
      1 (86.12 cM)5
    537911  NM_016928.21  NP_058624.21 
     1829547885 
    chicken
    (Gallus gallus)
    Aves TLR51 toll-like receptor 5 59.8(n)
    52.22(a)
      554217  NM_001024586.1  NP_001019757.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLR56
    toll-like receptor 5
    48(a)
    1 ↔ 1
    1(244700016-244729113)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004966471 toll-like receptor 5-like 54.13(n)
    47.71(a)
      100496647  XM_002940696.2  XP_002940742.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tlr5b1 toll-like receptor 5b 47.15(n)
    39.04(a)
      403139  NM_001130595.1  NP_001124067.1 


    ENSEMBL Gene Tree for TLR5 (if available)
    TreeFam Gene Tree for TLR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLR5 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR92  TLR102  TLR42  TLR82  
    TLR62  TLR32  TLR22  

    TLR5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    TLR5_HUMAN, O60602: Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin
    signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused
    by Legionella pneumophila [MIM:608556]. It also provides protection against systemic lupus erythematosus


    Selected SNPs for TLR5 (see all 909)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57441681,2
    C,Fpathogenic1230080615(-) ATCTCC/TGAGAC 2 R * stg111Minor allele frequency- G:0.00NA EU NS WA 6151
    rs2019064121,2
    Cuntested1230081344(+) CAAGCG/AAGTTA 2 /R /C mis11Minor allele frequency- A:0.00EU 1321
    rs20724931,2,,4
    C,F,Oother1230080014(-) TATCAA/GTTGGC 2 N S mis123Minor allele frequency- G:0.16EA NA EU NS 8409
    rs57441951,2
    C,F--223282293(-) TCTTCGTTTT   
      CTTC
    /-
    AAAAT
    1 -- ds50013Minor allele frequency- -:0.27NA EU 94
    rs668774051,2
    C--223288989(+) TGATA-/AGA   
      C
    /GACA
    ACAAA
    1 -- int11NA 2
    rs1119019041,2
    C,F--223290047(+) TTTACG/AAAGAG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1134983481,2
    C,F--223290309(+) GTGCTC/TTTCAG 1 -- int13Minor allele frequency- T:0.03NA WA 240
    rs731181031,2
    C,F--223290589(+) CCTGCC/GAAGCC 1 -- int13Minor allele frequency- G:0.07WA CSA 122
    rs1127313511,2
    F--223290623(+) GGCCCG/CTGAGC 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs711785301,2
    C--223293320(+) ATAAA-/A/ATAAAATAAAATAAAATAAAATAATAAAATAAAATAAAATAAA
    ATAAAATAAATAAAATAAAATAAAATAAATAAAATAAAATAAAATAAA
    TAAAA
    1 -- int11NA 2

    HapMap Linkage Disequilibrium report for TLR5 (223282748 - 223316624 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TLR5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1122523CNV Insertion17803354
    nsv873207CNV Loss21882294
    nsv832659CNV Gain17160897

    Human Gene Mutation Database (HGMD): TLR5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR5
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603031   
    OMIM disorders: 608556  601744  615557  
    UniProtKB/Swiss-Prot: TLR5_HUMAN, O60602
  • Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often
    febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin,
    joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the
    regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an
    elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for TLR5 (see all 63):    About MalaCards
    systemic lupus erythematosus    lemierre's syndrome    legionnaires' disease    systemic lupus erythematosus 1
    ocular toxoplasmosis    melioidosis, susceptibilty to    legionaire disease    lupus erythematosus
    septic arthritis    melioidosis    typhoid fever    bacteriuria
    pouchitis    chronic granulomatous disease    legionellosis    duodenal ulcer
    pandas    bronchiolitis obliterans    bronchiolitis    duodenitis

    4 diseases from the University of Copenhagen DISEASES database for TLR5:
    Inflammatory bowel disease     Melioidosis     Pneumonia     Influenza

    TLR5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for TLR5 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 42.4 3 12185085 (1), 14688376 (1), 19596770 (1)
    inflammatory bowel diseases 37.2 1 16439468 (1)
    colitis ulcerative 36.5 1 20083854 (1)
    colitis 35.8 5 19774646 (3)
    legionnaires disease 34.7 2 14623910 (1), 15747241 (1)
    pouchitis 31.5 1 16770571 (1)
    pneumonia 25.3 3 18490781 (1), 14623910 (1)
    necrosis 19.8 6 18538140 (2), 19267841 (1), 16903774 (1), 16960116 (1)
    bacterial infections 19.6 3 15339910 (1)
    sepsis 11.2 1 15794413 (1)

    Genetic Association Database (GAD): TLR5
    Human Genome Epidemiology (HuGE) Navigator: TLR5 (42 documents)

    Export disorders for TLR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLR5 gene, integrated from 10 sources (see all 340):
    (articles sorted by number of sources associating them with TLR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. (PubMed id 16027372)1, 2, 3, 4, 9 Hawn T.R.... Aderem A. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)1, 2, 3, 9 Rock F.L.... Bazan J.F. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. (PubMed id 17442957)1, 2, 9 Ivison S.M.... Steiner T.S. (J. Immunol. 2007)
    4. Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam. (PubMed id 15747241)1, 4, 9 Dunstan S.J....Farrar J.J. (J. Infect. Dis. 2005)
    5. Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease. (PubMed id 16439468)1, 4, 9 Gewirtz A.T....Cho J.H. (Am. J. Physiol. Gastrointest. Liver Physiol. 2006)
    6. Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus. (PubMed id 19473567)1, 4, 9 SA!nchez E....Martin J. (Clin. Exp. Rheumatol. 2009)
    7. Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (PubMed id 18809506)1, 4, 9 Moura S.B....MagalhALes Queiroz D.M. (Microbes Infect. 2008)
    8. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. (PubMed id 9596645)1, 2, 9 Chaudhary P.M.... Nelson P.S. (Blood 1998)
    9. A history of recurrent positive selection at the toll-like receptor 5 in primates. (PubMed id 19179655)1, 2, 9 Wlasiuk G.... Nachman M.W. (Mol. Biol. Evol. 2009)
    10. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. (PubMed id 14623910)1, 2, 9 Hawn T.R.... Aderem A. (J. Exp. Med. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7100 HGNC: 11851 AceView: TLR5 Ensembl:ENSG00000187554 euGenes: HUgn7100
    ECgene: TLR5 Kegg: 7100 H-InvDB: TLR5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLR5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLR5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLR5 gene:
    Search GeneIP for patents involving TLR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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