Aliases for TLR5 Gene
External Ids for TLR5 Gene
Previous HGNC Symbols for TLR5 Gene
Previous GeneCards Identifiers for TLR5 Gene
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
GeneCards Summary for TLR5 Gene
TLR5 (Toll Like Receptor 5) is a Protein Coding gene. Diseases associated with TLR5 include Legionaire Disease and Melioidosis. Among its related pathways are TRAF Pathway and Bacterial infections in CF airways. GO annotations related to this gene include transmembrane signaling receptor activity and interleukin-1 receptor binding. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot for TLR5 Gene
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.