Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TLR4 Gene

protein-coding GIFtS: 70
GCID: GC09P120466

toll-like receptor 4

Explore 265 diseases affiliated with
TLR4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Toll-Like Receptor 4¹ ²		TLR-4¹ ²
HToll¹		TOLL²
ARMD10¹ ² ⁵		Homolog Of Drosophila Toll²
CD284¹ ²		CD284 Antigen³

External Ids:	HGNC: 11850¹	Entrez Gene: 7099²	Ensembl: ENSG00000136869⁷	OMIM: 603030⁵	UniProtKB: O00206³

ORGUL members:
	NONCODE:n406639

Export aliases for TLR4 gene to outside databases

Previous GC identifers: GC09P111571 GC09P112113 GC09P113920 GC09P115842 GC09P117546 GC09P119506 GC09P090084

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR4:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in

pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share

structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on

infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The

various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events

induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated

with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for

this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: TLR4_HUMAN, O00206

Function: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS).

Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved

histidines and are, therefore, species-specific

summary for TLR4:

Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the

innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been

reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like

receptors are activated by molecules associated with biological threat and are highly specific towards

evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella

and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous

ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor

activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates

downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which

converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This

can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to

toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR4 (TLR 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TLR4 gene promoter:
Sp1 AP-1 ATF-2 PPAR-alpha AREB6 POU2F1 POU2F1a c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLR4 promoter sequence

Search SABiosciences Chromatin IP Primers for TLR4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.1 Ensembl cytogenetic band: 9q33.1 HGNC cytogenetic band: 9q33.1

TLR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR4 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P120466: view genomic region (about GC identifiers)

Start:	120,466,460 bp from pter	End:	120,479,768 bp from pter
Size:	13,309 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TLR4_HUMAN, O00206 (See protein sequence)

Recommended Name: Toll-like receptor 4 precursor

Size: 839 amino acids; 95680 Da

Subunit: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and

TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts

with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3 (By similarity).

Interacts with HSP90B1. The interaction with both CNPY3 and HSP90B1 is required for proper folding in the endoplasmic

reticulum. Interacts with MLK4; this interaction leads to negative regulation of TLR4 signaling

Subcellular location: Membrane; Single-pass type I membrane protein

Miscellaneous: His-456 and His-458 are found in TLR4 of human and several other primate species and may be responsible

for inflammatory responses triggered by nickel (Ni(2+)). Ni(2+) may cross-link the two receptor monomers through

specific histidines, triggering the formation of a dimer that structurally resembles that induced by LPS. This process

may be the basis for the development of contact allergy to Ni(2+). A mouse model of contact allergy to Ni(2+) in which

TLR4-deficient mice expresses human TLR4 has been proposed

6/10 PDB 3D structures from and Proteopedia for TLR4 (see all 10):

2Z62 (3D)

2Z63 (3D)

2Z65 (3D)

2Z66 (3D)

3FXI (3D)

3UL7 (3D)

Secondary accessions: A8K1Y8 A9XLP9 A9XLQ0 A9XLQ1 B4E194 D1CS52 D1CS53 Q5VZI8 Q5VZI9 Q9UK78 Q9UM57

Alternative splicing: 3 isoforms: O00206-1 O00206-2 O00206-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLR4: NX_O00206

Post-translational modifications:

N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell

surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient

in interaction with LPS¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00206

TLR4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_003257.1 NP_612564.1 NP_612567.1

ENSEMBL proteins:

ENSP00000377997 ENSP00000363089

Reactome Protein details: O00206
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TLR4 (TLR4/MD-2 Complex, TLR4)
	Enzo Life Sciences proteins for TLR4
	OriGene Purified Protein: TLR4 OriGene Protein Over-expression Lysate: TLR4 OriGene Custom Protein Services for TLR4
	GenScript Custom Purified and Recombinant Proteins Services for TLR4
	Novus Biologicals TLR4 Proteins Novus Biologicals TLR4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TLR4

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19740627
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	15027902
GO:0009897	external side of plasma membrane	IDA	16514062
GO:0009986	cell surface	--	--

TLR4 for ontologies About GeneDecksing

TLR4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for TLR4
	Cell Signaling Technology (CST) Antibodies for TLR4
	OriGene Antibodies (see all 3): TLR4 OriGene Custom Antibody Services for TLR4
	GenScript Custom Superior Antibodies Services for TLR4
	Novus Biologicals TLR4 Antibodies
	Search for Antibodies for TLR4 at Abcam
	Uscn Antibodies for TLR4
	ThermoFisher Antibody for TLR4

Assay Products for TLR4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for TLR4
	GenScript Custom Assay Services for TLR4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TLR4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TLR4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000483 Cys-rich_flank_reg_C

IPR027168 TLR4

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

IPR000157 TIR_dom

Graphical View of Domain Structure for InterPro Entry O00206

ProtoNet protein and cluster: O00206

3 Blocks protein families:

IPB000157 TIR domain

IPB000483 Cysteine-rich flanking region

IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: TLR4_HUMAN, O00206

Domain: The TIR domain mediates interaction with NOX4

Similarity: Belongs to the Toll-like receptor family

Similarity: Contains 18 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 TIR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TLR4_HUMAN, O00206

Function: Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS).

Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved

histidines and are, therefore, species-specific

Genatlas biochemistry entry for TLR4:

Drosophila transmembrane receptor Toll homolog 4,specifically expressed in placenta,and on cells of the immune system

binding directly to TLR2 and essential component of liposaccharides (LPS) receptor,inducing the LPS signaling pathway

miRNA Products:		miRTarBase miRNAs that target TLR4: hsa-let-7i (MIRT003050)

		OriGene 3'-UTR Clone: TLR4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLR4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TLR4 (see all 16):
		hsa-miR-549 hsa-miR-140-5p hsa-miR-219-1-3p hsa-miR-3938 hsa-miR-642a hsa-miR-4328 hsa-miR-944 hsa-miR-3074-3p

		SwitchGear 3'UTR luciferase reporter plasmid: TLR4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR4 (see all 7) OriGene shRNA RFP: TLR4 OriGene siRNA: TLR4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TLR4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR4 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TLR4 (NM_138554)
		Sino Biological Human cDNA Clone for TLR4
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TLR4
		Search LifeMap BioReagents cell lines for TLR4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR4

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001530	lipopolysaccharide binding	NAS	10835634
GO:0001875	lipopolysaccharide receptor activity	IDA	19252480
GO:0004872	receptor activity	TAS	10426995
GO:0004888	transmembrane signaling receptor activity	NAS	11970998
GO:0005515	protein binding	IPI	19509286

TLR4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TLR4:

Increased viability with 4OH t

Animal Models:
Mouse knock-outs for TLR4: Tlr4^tm1Aki Tlr4^tm1.1Djh
15/23 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Tlr4) (see all 23):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system
integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle

TLR4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/37 super-pathways (see all 37) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/10 pathways (see all 10)
Toll Like Receptor TLR1:TLR2 Cascade	0.78	MyD88-independent cascade	0.72
Toll Like Receptor TLR6:TLR2 Cascade	0.78	Toll Like Receptor 3 (TLR3) Cascade	0.72
Toll Like Receptor 2 (TLR2) Cascade	0.78	Activated TLR4 signalling	0.63
MyD88:Mal cascade initiated on plasma membrane	0.78	Toll Like Receptor 4 (TLR4) Cascade	0.61

Toll-like receptor signaling pathway

Toll-like receptor signaling pathway	1.00	Chagas disease (American trypanosomiasis)	0.31
Toll-like receptor signaling pathway	0.97	Inflammasome Activation Pathways	0.29
Toll-Like receptor Signaling Pathways	0.51

Auto ubiquitination of TRAF6 bound to the activated TLR complex

Auto ubiquitination of TRAF6 bound to the activated TLR complex	1.00	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.62
Auto-ubiquitination of TRAF3	0.83	IKK complex recruitment mediated by RIP1	0.50
TRAF6 mediated induction of TAK1 complex	0.73	TRIF-mediated programmed cell death	0.40

Toll Comparative Pathway

Toll Comparative Pathway	1.00	Immune response MIF in innate immunity response	0.46
TLR-TRIF Pathway	0.61	iNOS Signaling	0.34
Immune response_MIF in innate immunity response	0.46

Th17 Differentiation

Th17 Differentiation

1.00

IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for TLR4

	Transcription NF-kB signaling pathway
	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Immune response MIF in innate immunity response
	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

5/6 R&D Systems Pathways for TLR4 (see all 6)

	Inflammasome Activation Pathways
	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	A-beta Uptake & Degradation
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways

5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR4 (see all 21)

	14-3-3 Induced Apoptosis
	MSP-RON Signaling
	Toll-Like Receptors Pathway
	TRAF Pathway
	IL-10 Pathway

1 Cell Signaling Technology (CST) Pathway for TLR4

NF-kappaB Signaling

1 Tocris Bioscience Pathway for TLR4

Toll-like Receptor Pathway

5/8 GeneGo (Thomson Reuters) Pathways for TLR4 (see all 8)

	Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
	Immune response Bacterial infections in normal airways
	Immune response MIF in innate immunity response
	Immune response TLR signaling pathways
	Bacterial infections in CF airways

2 BioSystems Pathways for TLR4

	Pathogenic Escherichia coli infection
	Toll-like receptor signaling pathway

5/18 Reactome Pathways for TLR4 (see all 18)

	Auto-ubiquitination of TRAF3
	IKK complex recruitment mediated by RIP1
	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades

5/13 Kegg Pathways (Kegg details for TLR4) (see all 13):

	Phagosome
	Toll-like receptor signaling pathway
	Pathogenic Escherichia coli infection
	Pertussis
	Leishmaniasis

TLR4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TLR4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/92 Interacting proteins for TLR4 (O00206^{1, 2, 3} ENSP00000363089⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 92)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LY96	Q9Y6Y9¹^,³, ENSP00000284818⁴	EBI-528701,EBI-1539247 I2D: score=6 STRING: ENSP00000284818
TIRAP	P58753¹^,³, ENSP00000376445⁴	EBI-528701,EBI-528644 I2D: score=5 STRING: ENSP00000376445
DEFB4A	O15263³, ENSP00000303532⁴	I2D: score=1 STRING: ENSP00000303532
MYD88	Q99836²^,³, ENSP00000379625⁴	MINT-3981845 I2D: score=7 STRING: ENSP00000379625
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-3981896 I2D: score=2 STRING: ENSP00000275493

About this table

Gene Ontology (GO): 5/88 biological process terms (GO ID links to tree view) (see all 88): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	ISS	--
GO:0001666	response to hypoxia	--	--
GO:0002218	activation of innate immune response	--	--
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002282	microglial cell activation involved in immune response	--	--

TLR4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TLR4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for TLR4

Compounds for TLR4 available from Tocris Bioscience About this table

Compound	Action	CAS #
GIT 27	Immunomodulator; reduces production of pro-inflammatory cytokines	[6501-72-0]

2 DrugBank Compounds for TLR4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
3-Hydroxy-Myristic Acid	--	--	target	--	10592235
MYRISTIC ACID	--	--	target	--	10592235

10/95 Novoseek chemical compound relationships for TLR4 gene (see all 95) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipoteichoic acid	83.8	64	12691617 (3), 12011760 (3), 11160242 (2), 17296755 (2) (see all 37)
endotoxin	81.3	302	17977838 (9), 18519568 (5), 17121827 (5), 19368968 (5) (see all 99)
peptidoglycan	80.9	106	12874299 (6), 16239565 (3), 15142865 (2), 17942642 (2) (see all 65)
poly(i-c)	73.7	15	14991609 (1), 16115611 (1), 16365459 (1), 16380383 (1) (see all 15)
flagellin	73.5	28	18397908 (2), 16365459 (1), 18256754 (1), 19955831 (1) (see all 25)
muramyl dipeptide	68.4	4	15617523 (1), 15839897 (1), 16299289 (1)
drosomycin	67.8	10	10489372 (1), 8808632 (1), 10973475 (1), 19934223 (1) (see all 7)
loxoribine	65.2	1	15749901 (1)
polyinosinic-polycytidylic acid	63.3	17	18031817 (1), 19578865 (1), 18184197 (1), 19863438 (1) (see all 11)
hbd2	60.8	11	16219107 (5), 15854033 (1), 17241164 (1), 20008534 (1)

Search CenterWatch for drugs/clinical trials and news about TLR4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TLR4 gene (4 alternative transcripts):

NM_003266.3 NM_138554.4 NM_138557.2 NM_138556.1

Unigene Cluster for TLR4:

Toll-like receptor 4

Hs.174312 [show with all ESTs]

Unigene Representative Sequence: NM_003266

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000394487 ENST00000355622(uc004bka.3 uc004bjz.3 uc004bkb.3)

ENST00000472304 ENST00000490685

miRNA Products:		OriGene 3'-UTR Clone: TLR4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLR4
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TLR4 (see all 16):
		hsa-miR-549 hsa-miR-140-5p hsa-miR-219-1-3p hsa-miR-3938 hsa-miR-642a hsa-miR-4328 hsa-miR-944 hsa-miR-3074-3p

		SwitchGear 3'UTR luciferase reporter plasmid: TLR4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR4 (see all 7) OriGene shRNA RFP: TLR4 OriGene siRNA: TLR4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR4 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TLR4 (NM_138554)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLR4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TLR4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR4
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR4

Additional cDNA sequence:

AB445638.1 AK226155.1 AK290053.1 AK293068.1 AK303730.1 BC025294.1 BC117422.1 BC143841.1

U69193.1 U88880.1

5 DOTS entries:

DT.97839126 DT.100020339 DT.99941363 DT.121172426 DT.75168146

24/70 AceView cDNA sequences (see all 70):

NM_138554 NM_138557 Z42560 BM931788 N42522 AI082399 BF439941 BX642592

AI086117 AW016347 AA598398 BX473935 AI356888 AX752005 AA490278 CA417825

BQ020285 NM_003266 BU675644 BX280079 AI332385 BQ233558 AI371874 CA442537

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TLR4 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c
SP1:											-
SP2:							-				-
SP3:							-		-		-
SP4:

ECgene alternative splicing isoforms for TLR4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TLR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAGTGTTC

About this image

TLR4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

CD31, CD144 positive cells (Two-step protocol fo...)

See TLR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLR4

SOURCE GeneReport for Unigene cluster: Hs.174312

UniProtKB/Swiss-Prot: TLR4_HUMAN, O00206

Tissue specificity: Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes,

macrophages, dendritic cells and several types of T-cells

SABiosciences Expression via Pathway-Focused PCR Arrays including TLR4 (see all 17):

Toll-Like Receptor Signaling Pathway in human mouse rat

Liver Cancer in human mouse rat

Inflammatory Response & Autoimmunity in human mouse rat

T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLR4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TLR4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR4
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TLR4 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TLR4¹	toll-like receptor 4	55.84(n) 46.69(a)		417241 NM_001030693.1 NP_001025864.1
lizard (Anolis carolinensis)	Reptilia	TLR4⁶	--	44(a)	1 ↔ 1	GL343450.1(659590-664285)
zebrafish (Danio rerio)	Actinopterygii	tlr4ba¹	toll-like receptor 4b, duplicate a	50(n) 39.42(a)		403131 NM_001131051.1 NP_001124523.1
fruit fly (Drosophila melanogaster)	Insecta	Tehao⁶ Tl⁶ (see all 4)	Toll (see all 4)	17(a) 13(a) (see all 4)	possible ortholog possible ortholog (see all 4)	2L(13435622-13439333) 3R(22624765-22668125)

ENSEMBL Gene Tree for TLR4 (if available)
TreeFam Gene Tree for TLR4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TLR4 gene

CD180² ENSG00000173366² TLR7² TLR1² TLR9² TLR5² TLR10² LRRC33²

TLR8² TLR6² LRRC32² TLR3² TLR2²

2 SIMAP similar genes for TLR4 using alignment to 10 protein entries: TLR4_HUMAN (see all proteins):

TLR-4 SLIT2

TLR4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: TLR4_HUMAN, O00206

Polymorphism: Allele TLR4*B (Gly-299, Ile-399) is associated with a blunted response to inhaled LPS

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4986791^1,2	C,F,H,	pathogenic	98275677(+)	`GACAAC/TCAGCC`	6	T I	mis¹		24		MN NA EU NS EA	7707
rs4986790^1,2	C,F,H,	pathogenic	98275977(+)	`CGATGA/GTATTA`	6	D G	mis¹		36		MN NA EU NS EA CA WA	11133
rs137853920^1,2	C,F,	untested	98276031(+)	`CCTGTG/ACAATT`	6	/Y /C	mis¹		2		NA EU	5863
rs200276033^1,2	C	other	98276007(+)	`ATTCCA/GATTAG`	6	Q R	mis¹		0	--	--	--	--
rs11536862^1,2	C,F,H	--	90082637(+)	`GAGCAA/GAGCTT`	3	--	us2k¹		7		NA EU NS EA	514
rs56131535^1,2	C,	--	90083004(+)	`TGTAAC/TGATGA`	3	--	us2k¹		1		NA	2
rs111949799^1,2		--	90083077(+)	`ATCTTC/TGTTTT`	3	--	us2k¹		1		CSA	2
rs7866214^1,2	C,F,H,	--	90083200(+)	`CACATT/CTTACA`	3	--	us2k¹		14		NS EA NA EU	1646
rs11536863^1,2	C,	--	90083374(+)	`GAGTAC/TGTATC`	3	--	us2k¹		6		NA EU WA	214
rs11536864^1,2	C,	--	90083457(+)	`CTAACG/ATGTGG`	3	--	us2k¹		3		NA EU	92

HapMap Linkage Disequilibrium report for TLR4 (120466460 - 120479768 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TLR4: --
Human Gene Mutation Database (HGMD): TLR4

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR4

DNA2.0 Custom Variant and Variant Library Synthesis for TLR4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TLR4 for disorders           About GeneDecksing

OMIM gene information: 603030
OMIM disorders: 611488  114500
UniProtKB/Swiss-Prot: TLR4_HUMAN, O00206

Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:611488].

ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In

most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid

that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane

20/265 diseases for TLR4 (see all 265): About MalaCards

macular degeneration, age-related, 10 perinatal necrotizing enterocolitis marginal zone b-cell lymphoma endotoxin hyporesponsiveness

hyper-ige syndrome niemann-pick disease diffuse large b-cell lymphoma hypersensitivity reaction type ii disease

b-cell lymphomas cleft lip/palate age related macular degeneration anterior uveitis

hemolytic-uremic syndrome patent ductus arteriosus macular degeneration graft versus host disease

sclerosing cholangitis mycobacterial infection primary sclerosing cholangitis boutonneuse fever

13 diseases from the University of Copenhagen DISEASES database for TLR4:

Inflammatory bowel disease Atherosclerosis Periodontitis Perinatal necrotizing enterocolitis

Asthma Pneumonia Arthritis Liver disease

Hypersensitivity reaction type II disease Cancer Mastitis Heart disease

Hypersensitivity reaction type I disease

10/93 Novoseek disease relationships for TLR4 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	74.6	175	18928988 (3), 20067961 (3), 19390489 (3), 19359427 (3) (see all 99)
necrosis	73.4	169	15325567 (4), 16970685 (2), 17304101 (2), 17529905 (2) (see all 99)
gram-negative bacterial infections	73	20	19326213 (1), 18644971 (1), 17456342 (1), 18437214 (1) (see all 11)
sepsis	67	128	15086396 (6), 15614130 (4), 17456342 (4), 15489631 (4) (see all 53)
bacterial infections	66.3	34	12853386 (3), 16738534 (2), 11260138 (1), 11781369 (1) (see all 28)
inflammatory bowel diseases	60.1	18	19710105 (2), 15655821 (1), 11083826 (1), 20375592 (1) (see all 17)
shock septic	59.4	20	20441696 (2), 15328161 (1), 16878028 (1), 15520404 (1) (see all 15)
tumors	53.9	233	19318560 (8), 19643479 (4), 15325567 (4), 19155492 (4) (see all 99)
atherosclerosis	53.8	76	17367503 (4), 15894821 (3), 17872459 (2), 17849054 (2) (see all 50)
colitis ulcerative	52.8	12	15207785 (3), 17538633 (1), 16085746 (1), 18942754 (1) (see all 11)

Genetic Association Database (GAD): TLR4
Human Genome Epidemiology (HuGE) Navigator: TLR4 (482 documents)

Export disorders for TLR4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TLR4 gene, integrated from 9 sources (see all 2537):
(articles sorted by number of sources associating them with TLR4)

Utopia: connect your pdf to the dynamic
world of online information

Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. (PubMed id 15829498)^{1, 2, 4, 9} Zareparsi S.... Swaroop A. (2005)
A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)^{1, 2, 3, 9} Rock F.L.... Bazan J.F. (1998)
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. (PubMed id 10835634)^{1, 2, 4} Arbour N.C.... Schwartz D.A. (2000)
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. (PubMed id 9237759)^{1, 2, 3} Medzhitov R....Janeway C.A. (1997)
Association between polymorphisms in the Toll-like receptor 4, CD14, and CARD15/NOD2 and inflammatory bowel disease in the Greek population. (PubMed id 15655821)^{1, 4, 9} Gazouli M....Gorgoulis V.G. (2005)
MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. (PubMed id 11706042)^{1, 2, 9} da Silva Correia J. and Ulevitch R.J. (2002)
NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? (PubMed id 15190267)^{1, 4, 9} Arnott I.D....Satsangi J. (2004)
Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia. (PubMed id 15258789)^{1, 4, 9} Reismann P....Bierhaus A. (2004)
Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles. (PubMed id 12324481)^{1, 4, 9} Schmitt C....Pahl A. (2002)
Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation. (PubMed id 11529488)^{1, 4, 9} Lorenz E....Clark J.G. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7099	HGNC: 11850	AceView: TLR4	Ensembl:ENSG00000136869	euGenes: HUgn7099
ECgene: TLR4	Kegg: 7099	H-InvDB: TLR4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TLR4	Pharmacogenomics, SNPs, Pathways
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt134.shtml

Intellectual Property for TLR4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TLR4 gene:
Search GeneIP for patents involving TLR4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for TLR4 (TLR4)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for TLR4 (TLR4)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for TLR4 (TLR4/MD-2 Complex)

	OriGene Antibodies for TLR4		OriGene shRNA RFP for TLR4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLR4
	OriGene Protein Over-expression Lysate for TLR4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TLR4		OriGene 3'-UTR Clone for TLR4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TLR4		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TLR4		OriGene Custom Protein Services for TLR4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLR4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR4
	Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR4

	GenScript Custom Purified and Recombinant Proteins Services for TLR4		GenScript cDNA clones with any tag delivered in your preferred vector for TLR4
	GenScript Custom Assay Services for TLR4		GenScript Custom Superior Antibodies Services for TLR4
	GenScript Custom overexpressing Cell Line Services for TLR4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for TLR4

	Regulatory tfbs in TLR4 promoter
	Search Chromatin IP Primers for TLR4
	RT² qPCR Primer Assay in human, mouse, rat TLR4
	GNC Network for TLR4
	SABiosciences PCR Arrays including human, mouse, rat TLR4

Tocris compounds for TLR4

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for TLR4
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Drugs/Proteins for TLR4
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TLR4 antibodies
	TLR4 proteins
	TLR4 lysates

	Search for Antibodies for TLR4 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TLR4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TLR4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TLR4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR4

	SwitchGear 3'UTR luciferase reporter plasmids for TLR4
	SwitchGear Promoter luciferase reporter plasmids for TLR4

ThermoFisher Antibody for TLR4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TLR4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TLR4 Gene

toll-like receptor 4

Aliases
for TLR4 gene

Summaries
for TLR4 gene

Genomic Views
for TLR4 gene

Proteins
for TLR4 gene

Protein Domains /
Families
for TLR4 gene

Function
for TLR4 gene

Pathways & Interactions
for TLR4 gene

Drugs & Compounds
for TLR4 gene

Transcripts
for TLR4 gene

Expression
for TLR4 gene

Orthologs
for TLR4 gene

Paralogs
for TLR4 gene

Genomic Variants
for TLR4 gene

Disorders / Diseases
for TLR4 gene

Publications
for TLR4 gene

External Searches for TLR4 gene

Genome Databases showing TLR4 gene

Other Databases showing TLR4 gene

Specialized Databases showing TLR4 gene

Intellectual Property
for TLR4 gene

Products
for TLR4 gene

View Random Gene

Spondylitis Ankylosing
Genetic Susceptibility
sepsis
Filariasis
Dermatitis Atopic
Cystic Fibrosis
Colitis Ulcerative
Shock Hemorrhagic
AIRWAYS DISEASE
allergy
Atherosclerosis
Carrier State
Acute anterior uveitis
Gram-Positive Bacterial Infections
Asthma
AIDS
Aspergillosis
cell damage
Thrombocytopenia
Ileal Diseases
ADENOCARCINOMA GASTRIC
Lymphoma
Periodontal Diseases
Shock
Meningococcal diseases
Bronchoalveolar Lavage Fluid
acute pancreatitis
Inflammation
Tuberculosis
Monocytic leukemia
Melioidosis
Hepatitis B
Rheumatoid Arthritis
Pneumonia
Keratitis
Tumors
Cardiovascular Diseases
Necrosis
Autoimmunity
Asthma allergic
Bronchiolitis
Plant Diseases
Glioblastoma
Carotid Atherosclerosis
virus infection
Preeclampsia
Hepatitis C
Coronary Heart Disease
Shock Septic
Colitis
Gastric Cancer
Myeloid Leukemia
Melanoma
Autoimmune Diseases
Critically Ill
Salmonella infections
atopy
Pyelonephritis
mycobacterial infection
atherosclerotic plaque
Systemic Inflammatory Response Syndrome
Bacterial Infections
Leukemia
Infectious disease
neurodegeneration
Shock Endotoxic
HEPATOCELLULAR CARCINOMA
Spondylarthropathies
Cancer Lung
ASPERGILLOSIS INVASIVE
Inflammatory Bowel Diseases
HEART FAILURE
INFECTION FUNGAL
Heart Diseases
Insulin Resistance
MALT Lymphoma
Adenoma
Chronic periodontitis
Gram-Negative Bacterial Infections
PELVIC INFLAMMATION
Lymphocytic Leukemia Chronic B-Cell
Gastritis
Pneumonia Bacterial
SKIN LESION
Hepatitis C Chronic
Autoimmune Response
Chorioamnionitis
STROKE
Pouchitis
Infection chronic
Sexually Transmitted Diseases
Lupus Erythematosus Systemic
Arthritis

Advanced Search

Export list of displayed genes

TLR4 Gene

toll-like receptor 4

Aliasesfor TLR4 gene

Summariesfor TLR4 gene

Genomic Viewsfor TLR4 gene

Proteinsfor TLR4 gene

Protein Domains /Familiesfor TLR4 gene

Functionfor TLR4 gene

Pathways & Interactionsfor TLR4 gene

Drugs & Compoundsfor TLR4 gene

Transcriptsfor TLR4 gene

Expression for TLR4 gene

Orthologsfor TLR4 gene

Paralogsfor TLR4 gene

Genomic Variantsfor TLR4 gene

Disorders / Diseasesfor TLR4 gene

Publicationsfor TLR4 gene

External Searches for TLR4 gene

Genome Databases showing TLR4 gene

Other Databases showing TLR4 gene

Specialized Databases showing TLR4 gene

Intellectual Propertyfor TLR4 gene

Productsfor TLR4 gene

View Random Gene

Aliases
for TLR4 gene

Summaries
for TLR4 gene

Genomic Views
for TLR4 gene

Proteins
for TLR4 gene

Protein Domains /
Families
for TLR4 gene

Function
for TLR4 gene

Pathways & Interactions
for TLR4 gene

Drugs & Compounds
for TLR4 gene

Transcripts
for TLR4 gene

Expression
for TLR4 gene

Orthologs
for TLR4 gene

Paralogs
for TLR4 gene

Genomic Variants
for TLR4 gene

Disorders / Diseases
for TLR4 gene

Publications
for TLR4 gene

Intellectual Property
for TLR4 gene

Products
for TLR4 gene