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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLR3 Gene

protein-coding   GIFtS: 69
GCID: GC04P186990

toll-like receptor 3
 Explore 99 diseases affiliated with
TLR3 via
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 Human Malady Compendium 
Biological research products
for TLR3    

Aliases
for TLR3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Toll-Like Receptor 31 2
CD2831 2
IIAE22
CD283 Antigen3

External Ids:    HGNC: 118491   Entrez Gene: 70982   Ensembl: ENSG000001643427   OMIM: 6030295   UniProtKB: O154553   

Export aliases for TLR3 gene to outside databases

Previous GC identifers: GC04P188024 GC04P187670 GC04P187574 GC04P187686 GC04P187365 GC04P187227 GC04P182742


Summaries
for TLR3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TLR3:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share
structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective
immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in
placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA
associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It
may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different
length transcripts has been noted for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing
TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to
NF-kappa-B activation, cytokine secretion and the inflammatory response

summary for TLR3:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR3 (TLR 3)


Genomic Views
for TLR3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR3 gene promoter:
         AP-1   ATF-2   NF-AT   NF-AT2   POU2F1   POU2F1a   NF-AT3   STAT3   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35

TLR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P186990:  view genomic region     (about GC identifiers)

Start:
 186,990,306 bp from pter      End:
 187,006,255 bp from pter
Size:
 15,950 bases      Orientation:
 plus strand

Proteins
for TLR3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455 (See protein sequence)
Recommended Name: Toll-like receptor 3 precursor  
Size: 904 amino acids; 103829 Da
Subunit: Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1 (By
similarity). Interacts with TICAM1. Homodimer formation is triggered by ligand binding and is required for TLR3
signaling. Binding of double-stranded RNA is required for the interaction with SRC
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane
4 PDB 3D structures from and Proteopedia for TLR3:
1ZIW (3D)        2A0Z (3D)        3ULU (3D)        3ULV (3D)    
Secondary accessions: Q4VAL2

Explore the universe of human proteins at neXtProt for TLR3: NX_O15455

Post-translational modifications:

  • Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15455

    • TLR3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003256.1  
    ENSEMBL proteins: 
     ENSP00000296795   ENSP00000423386   ENSP00000423684  
    Reactome Protein details: O15455
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TLR3
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    OriGene Protein Over-expression Lysate: TLR3
    OriGene Custom Protein Services for TLR3 
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    Novus Biologicals TLR3 Proteins
    Novus Biologicals TLR3 Lysate
    Sino Biological Recombinant Protein for TLR3
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLR3

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA19740627
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005887integral to plasma membrane TAS9435236


    TLR3 for ontologies           About GeneDecksing



    TLR3 Antibody Products: 
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    Novus Biologicals TLR3 Antibodies
    Search for Antibodies for TLR3 at Abcam  
    Uscn Antibodies for TLR3
    ThermoFisher Antibody for TLR3

    Assay Products for TLR3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for TLR3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TLR3

    Protein Domains /
    Families
    for TLR3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLR3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR027173 TLR3

    Graphical View of Domain Structure for InterPro Entry O15455

    ProtoNet protein and cluster: O15455

    4 Blocks protein families:
    IPB000157 TIR domain
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
    Domain: ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18 (By similarity)
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 22 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain
    Similarity: Contains 1 TIR domain


    Function
    for TLR3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing
    TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to
    NF-kappa-B activation, cytokine secretion and the inflammatory response

         Genatlas biochemistry entry for TLR3:
    Drosophila transmembrane receptor Toll homolog 3,with the major transcripts,predominantly expressed in placenta and
    pancreas,involved in immune defense

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: TLR3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR3 (see all 7)
    OriGene shRNA RFP: TLR3
    OriGene siRNA: TLR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TLR3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TLR3 (NM_003265)
    Sino Biological Human cDNA Clone for TLR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR3 

    Cell Line
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    Search LifeMap BioReagents cell lines for TLR3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding NAS12054664
    GO:0004872receptor activity TAS10426995
    GO:0004888transmembrane signaling receptor activity NAS12054664
    GO:0005515protein binding ----


    TLR3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TLR3: Tlr3tm1Flv Tlr3tm1Ttg
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tlr3):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     mortality/aging  muscle  nervous system  reproductive system  respiratory system 
     tumorigenesis 

    TLR3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TLR3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Auto ubiquitination of TRAF6 bound to the activated TLR complex
    		Auto ubiquitination of TRAF6 bound to the activated TLR complex1.00
    		Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon0.62
    		Auto-ubiquitination of TRAF30.83
    		IKK complex recruitment mediated by RIP10.50
    		TRAF6 mediated induction of TAK1 complex0.73
    		TRIF-mediated programmed cell death0.40
    2TRAF6 Mediated Induction of proinflammatory cytokines
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    		Activated TLR4 signalling0.63
    		MyD88-independent cascade 0.72
    		Toll Like Receptor 4 (TLR4) Cascade0.61
    		Toll Like Receptor 3 (TLR3) Cascade0.72
    		Toll-Like Receptors Cascades0.53
    3Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Inflammasome Activation Pathways0.29
    4Endosomal TLRs pass through the Golgi
    		Endosomal TLRs pass through the Golgi1.00
    		Trafficking and processing of endosomal TLR0.42
    		UNC93B1 delivers endosomal full-length TLRs to endolysosome1.00
    5Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway
    		Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway1.00
    		Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TLR3
        Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    5 R&D Systems Pathways for TLR3
        Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways
    Th17 Differentiation

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR3 (see all 9)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR3
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR3
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR3
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    1 BioSystems Pathway for TLR3 
        Toll-like receptor signaling pathway

    5/17        Reactome Pathways for TLR3 (see all 17)
        Auto-ubiquitination of TRAF3
    IKK complex recruitment mediated by RIP1
    Toll-Like Receptors Cascades
    UNC93B1 delivers endosomal full-length TLRs to endolysosome
    MyD88-independent cascade


    3         Kegg Pathways  (Kegg details for TLR3):
        Toll-like receptor signaling pathway
    Hepatitis C
    Influenza A


    TLR3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for TLR3 (O154552, 3 ENSP000002967954) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-2840093 MINT-2840114 I2D: score=2 STRING: ENSP00000274335
    SRCP129312, 3, ENSP000003509414MINT-2840132 MINT-2841760 I2D: score=2 STRING: ENSP00000350941
    TICAM1Q8IUC63, ENSP000002482444I2D: score=3 STRING: ENSP00000248244
    IRAK2O431873, ENSP000002564584I2D: score=2 STRING: ENSP00000256458
    CSKP412403, ENSP000002200034I2D: score=1 STRING: ENSP00000220003
    About this table

    Gene Ontology (GO): 5/51 biological process terms (GO ID links to tree view) (see all 51):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002224toll-like receptor signaling pathway ----
    GO:0002282microglial cell activation involved in immune response ----
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006952defense response ----


    TLR3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLR3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TLR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TLR3

    Compounds for TLR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Poly(I:C)TLR3 agonist[42424-50-0]
    10/22 Novoseek chemical compound relationships for TLR3 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 92.4 66 16384532 (3), 15845391 (3), 16142732 (3), 14688319 (2) (see all 38)
    polyinosinic-polycytidylic acid 92.1 72 17962643 (4), 19452017 (4), 19154402 (2), 18949355 (2) (see all 36)
    flagellin 77 14 16365459 (1), 19294011 (1), 19955831 (1), 19740321 (1) (see all 14)
    inosine monophosphate 74.2 13 17182588 (3), 17573354 (1), 18715647 (1), 15196204 (1) (see all 11)
    peptidoglycan 68.8 16 16365459 (1), 17114468 (1), 16670332 (1), 14996826 (1) (see all 12)
    rantes 67.9 14 19121387 (3), 19452017 (2), 16436653 (1), 14517278 (1) (see all 9)
    lipoteichoic acid 58.1 4 17114468 (1), 15652398 (1), 16052591 (1), 16175622 (1)
    tab-2 52.8 3 14982987 (2), 12609980 (1)
    2',5'-oligoadenylate 52.8 2 17669408 (1)
    imiquimod 51.6 2 19578865 (1), 19643938 (1)

    1 PharmGKB related drug/compound annotation for TLR3 gene
    Drug/compound PharmGKB Annotation
    Measles vaccinesCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about TLR3 

    Transcripts
    for TLR3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLR3 gene: 
    NM_003265.2  

    Unigene Cluster for TLR3:

    Toll-like receptor 3
    Hs.657724  [show with all ESTs]
    Unigene Representative Sequence: BC068487
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296795(uc003iyq.3) ENST00000513189 ENST00000512264(uc011ckz.2 uc003iyr.3)
    ENST00000504367 ENST00000508051

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR3 (see all 7)
    OriGene shRNA RFP: TLR3
    OriGene siRNA: TLR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR3
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    GenScript: all cDNA clones in your preferred vector: TLR3 (NM_003265)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLR3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR3

    Additional cDNA sequence: 

    AB445631.1 AK302143.1 AK314208.1 BC017954.1 BC043204.2 BC059372.1 BC068487.1 BC094737.1 
    BC096333.1 BC096334.3 BC096335.1 DQ445682.1 DQ470075.1 DQ470076.1 DQ470077.1 DQ470078.1 
    DQ470079.1 U88879.1 

    4 DOTS entries:

    DT.109361  DT.100664575  DT.101977909  DT.99984982 

    24/50 AceView cDNA sequences (see all 50):

    CF529473 NM_003265 AU135937 BC068487 BX104394 CF528559 BQ007482 BC059372 
    CF994731 BI559688 BU950410 CD109430 BF594247 U88879 BC043204 CB988158 
    CB989983 BC017954 BU929797 BX489678 AL048899 CB960574 BX489646 BI489939 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TLR3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
    SP1:                    -     -                           
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for TLR3

    Expression
    for TLR3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACTCTGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TLR3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TLR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLR3

    SOURCE GeneReport for Unigene cluster: Hs.657724

    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
    Tissue specificity: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells.
    Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is
    expressed most strongly in the brain, especially in astrocytes, glia, and neurons

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR3 (see all 8): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLR3
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    In Situ
    Assay Products:     
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    Orthologs
    for TLR3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLR3 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TLR31 toll-like receptor 3 67.01(n)
    62.06(a)    		   422720  NM_001011691.3  NP_001011691.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TLR36
    		 --
    		 58(a)
    		 1 ↔ 1
    		 5(112306736-112316700)
    zebrafish
    (Danio rerio)    		 Actinopterygii tlr31 toll-like receptor 3 52.99(n)
    49.2(a)    		   403126  NM_001013269.2  NP_001013287.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG95623   -- 26(a)
    (best of 2)    		     --


    ENSEMBL Gene Tree for TLR3 (if available)
    TreeFam Gene Tree for TLR3 (if available) 

    Paralogs
    for TLR3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLR3 gene
    CD1802  ENSG000001733662  TLR72  TLR12  TLR92  TLR52  TLR102  LRRC332  
    TLR42  TLR82  TLR62  LRRC322  TLR22  
    2 SIMAP similar genes for TLR3 using alignment to 7 protein entries:     TLR3_HUMAN (see all proteins):
    TLR2    TLR10

    TLR3 for paralogs           About GeneDecksing



    Genomic Variants
    for TLR3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
    Polymorphism: The Phe-412 allele (dbSNP:rs3775291) occurs with a frequency of 30% in populations with European and
    Asian ancestry, and confers some natural resistance to HIV-1 infection


    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TLR3
         1 CNV: 53588
    Human Gene Mutation Database (HGMD): TLR3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR3
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    Disorders / Diseases
    for TLR3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLR3 for disorders           About GeneDecksing

    OMIM gene information: 603029   
    OMIM disorders: 613002  
    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
  • Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2) [MIM:613002]. HSE is a rare
    • complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected
    individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over
    several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome.
    Note=TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a
    mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central
    nervous system

    20/99 diseases for TLR3 (see all 99):    About MalaCards
    tick-borne encephalitis    herpes simplex encephalitis    hyper-ige syndrome    surfactant protein c deficiency
    stevens-johnson syndrome    subacute sclerosing panencephalitis    age related macular degeneration    herpes simplex
    west nile virus    protein c deficiency    molluscum contagiosum    dengue hemorrhagic fever
    clear cell renal cell carcinoma    hemorrhagic fever    encephalitis    macular degeneration
    primary biliary cirrhosis    bronchiolitis obliterans    haemophilus influenzae    myocardial infarction

    5 diseases from the University of Copenhagen DISEASES database for TLR3:
    Influenza     Melanoma     Encephalitis     Herpes simplex
    Asthma

    10/29 Novoseek disease relationships for TLR3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 73.1 57 16877304 (2), 14575692 (2), 19452017 (2), 12672806 (2) (see all 36)
    inflammation 48.6 13 19752565 (2), 20387535 (2), 18403353 (1), 20483774 (1) (see all 9)
    hepatitis c chronic 38.3 1 19475618 (1)
    necrosis 32.7 9 14729660 (1), 15579900 (1), 16510559 (1), 18765427 (1) (see all 9)
    melanoma 32.1 27 17671143 (4), 19001446 (3), 19470740 (2), 17142768 (1) (see all 14)
    hepatitis c 30.8 3 19625408 (2), 18021446 (1)
    influenza 30.4 10 15579900 (3), 19231996 (3), 16399790 (2), 16517210 (1) (see all 5)
    bacterial infections 27.2 1 18083507 (1)
    herpes simplex 23.9 3 19025601 (1), 16847112 (1)
    pouchitis 20.9 3 16770571 (2)

    Genetic Association Database (GAD): TLR3
    Human Genome Epidemiology (HuGE) Navigator: TLR3 (55 documents)

    Export disorders for TLR3 gene to outside databases

    Publications
    for TLR3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLR3 gene, integrated from 9 sources (see all 632):
    (articles sorted by number of sources associating them with TLR3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)1, 2, 3 Rock F.L.... Bazan J.F. (1998)
    2. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. (PubMed id 18753640)1, 2, 9 Yang Z.... Zhang K. (2008)
    3. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. (PubMed id 15961631)1, 2, 9 Choe J....Wilson I.A. (2005)
    4. TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction. (PubMed id 12539043)1, 2, 9 Oshiumi H.... Seya T. (2003)
    5. A common polymorphism in TLR3 confers natural resistan ce to HIV-1 infection. (PubMed id 22174453)1, 2 Sironi M....Clerici M. (2012)
    6. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2 Nakajima T....Kimura A. (2008)
    7. The TLR3 signaling complex forms by cooperative receptor dimerization. (PubMed id 18172197)1, 2 Leonard J.N.... Segal D.M. (2008)
    8. TLR3 deficiency in patients with herpes simplex encephalitis. (PubMed id 17872438)1, 2 Zhang S.-Y.... Casanova J.-L. (2007)
    9. Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation. (PubMed id 17178723)1, 2 Sarkar S.N.... Sen G.C. (2007)
    10. Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. (PubMed id 16858407)1, 2 Johnsen I.B....Anthonsen M.W. (2006)

    External Searches for TLR3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TLR3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7098 HGNC: 11849 AceView: TLR3 Ensembl:ENSG00000164342 euGenes: HUgn7098
    ECgene: TLR3 Kegg: 7098 H-InvDB: TLR3

    Other Databases showing TLR3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TLR3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLR3 Pharmacogenomics, SNPs, Pathways
    TLR3basehttp://bioinf.uta.fi/TLR3base/

    Intellectual Property
    for TLR3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLR3 gene:
    Search GeneIP for patents involving TLR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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