Aliases for TLR3 Gene
Aliases for TLR3 Gene
External Ids for TLR3 Gene
- HGNC: 11849
- Entrez Gene: 7098
- Ensembl: ENSG00000164342
- OMIM: 603029
- UniProtKB: O15455
Previous GeneCards Identifiers for TLR3 Gene
- GC04P188024
- GC04P187670
- GC04P187574
- GC04P187686
- GC04P187365
- GC04P187227
- GC04P186990
- GC04P182742
Summaries for TLR3 Gene
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TLR3 Gene
TLR3 (Toll Like Receptor 3) is a Protein Coding gene. Diseases associated with TLR3 include Herpes Simplex Encephalitis 2 and Human Immunodeficiency Virus Type 1. Among its related pathways are Toll-like receptor signaling pathway and Akt Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and transmembrane signaling receptor activity. An important paralog of this gene is TLR7.
UniProtKB/Swiss-Prot for TLR3 Gene
-
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
-
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.
Additional gene information for TLR3 Gene
- Monarch Initiative
- Search for TLR3 at DataMed
- Search for TLR3 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR3 Gene
Genomics for TLR3 Gene
GeneHancer (GH) Regulatory Elements for TLR3 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04I186067 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 550.8 | -0.3 | -294 | 2.4 | CTCF IRF2 TAF1 SAP130 ARID4B MAX ZNF2 ZNF48 RAD21 ZNF7 | TLR3 RNU4-64P | |
GH04I186143 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 10.7 | +75.8 | 75768 | 1.9 | CTCF MAX ZNF76 SIN3A ZIC2 ZNF2 YY1 ZNF335 ZFHX2 POLR2A | FAM149A CYP4V2 TLR3 ENSG00000253013 RPSAP70 | |
GH04I186028 | Enhancer | 0.8 | Ensembl ENCODE | 10 | -38.4 | -38423 | 4.4 | CTCF RXRA ZNF189 MAX REST ZIC2 RAD21 NR2F2 YY1 JUND | TLR3 CFAP97 RNU4-64P | |
GH04I185835 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 5.3 | -230.2 | -230231 | 6.9 | FOXA2 INSM2 ZNF2 ETS1 ZEB1 ZNF335 RCOR1 FOS ZEB2 ZNF843 | SORBS2 TLR3 CCDC110 RPSAP70 LOC101928929 ENSG00000207497 GC04M185710 | |
GH04I186133 | Enhancer | 0.5 | ENCODE | 10.8 | +63.9 | 63930 | 0.1 | CTCF ZNF600 RAD21 TEAD3 | FAM149A TLR3 ENSG00000253013 RPSAP70 |
Regulatory Element Products
Genomic Locations for TLR3 Gene
- chr4:186,069,152-186,088,069
- (GRCh38/hg38)
- Size:
- 18,918 bases
- Orientation:
- Plus strand
- chr4:186,990,306-187,009,223
- (GRCh37/hg19)
Genomic View for TLR3 Gene
- Cytogenetic band:
-
- 4q35.1 by Ensembl
- 4q35.1 by Entrez Gene
- 4q35.1 by HGNC


RefSeq DNA sequence for TLR3 Gene
Proteins for TLR3 Gene
-
Protein details for TLR3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15455-TLR3_HUMAN
- Recommended name:
- Toll-like receptor 3
- Protein Accession:
- O15455
- B2RAI7
- B7Z7K0
- E6Y0F0
- E6Y0F1
- E9PGH4
- Q4VAL2
- Q504W0
Protein attributes for TLR3 Gene
- Size:
- 904 amino acids
- Molecular mass:
- 103829 Da
- Quaternary structure:
-
- Monomer and homodimer; dimerization is triggered by ligand-binding, the signaling unit is composed of one ds-RNA of around 40 bp and two TLR3 molecules, and lateral clustering of signaling units along the length of the ds-RNA ligand is required for TLR3 signal transduction. Interacts (via transmembrane domain) with UNC93B1; the interaction is required for transport from the ER to the endosomes. Interacts with SRC; upon binding of double-stranded RNA. Interacts with TICAM1 (via the TIR domain) in response to poly(I:C) and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436). The tyrosine-phosphorylated form (via TIR domain) interacts with WDFY1 (via WD repeat 2) in response to poly(I:C) (PubMed:25736436).
Three dimensional structures from OCA and Proteopedia for TLR3 Gene
Protein Expression for TLR3 Gene
Post-translational modifications for TLR3 Gene
- Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding.
- TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes.
- Glycosylation at posLast=5252, posLast=5757, isoforms=70, isoforms=124, posLast=196196, isoforms=247, isoforms=252, posLast=265265, isoforms=275, posLast=291291, posLast=398398, posLast=413413, isoforms=2507, posLast=636636, and isoforms=2662
Other Protein References for TLR3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TLR3 (TLR3)
- Cell Signaling Technology (CST) Antibodies for TLR3 (TLR3)
-
Custom Antibody ServicesOriGene Antibodies for TLR3
- Novus Biologicals Antibodies for TLR3
-
Abcam antibodies for TLR3
-
Cloud-Clone Corp. Antibodies for TLR3
- Invitrogen Antibodies for TLR3
- antibodies-online: Search results for 355 available TLR3 Antibodies ranked by validation data
- Compare Top TLR3 Antibodies
-
Recommended
- 4 FACS Antibodies (anti-rat)
- 12 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 29 WB Antibodies (anti-rat)
- 2 IP Antibodies (anti-mouse)
- 7 IF Antibodies (anti-mouse)
- 11 IHC (p) Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 25 FACS Antibodies (anti-mouse)
- 134 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 1 Func Antibody (anti-human)
- 2 IF Antibodies (anti-human)
- 7 IP Antibodies (anti-human)
- 16 IHC (p) Antibodies (anti-human)
- 32 FACS Antibodies (anti-human)
- 191 WB Antibodies (anti-human)
- GeneTex TLR3 antibody for TLR3
-
Custom Antibody ServicesProSci Antibodies for TLR3
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR3
- Sino Biological Antibodies for TLR3
Protein Products
- R&D Systems Proteins and Enzymes for TLR3
-
OriGene Purified Proteins for TLR3
- Search Origene for MassSpec and Protein Over-expression Lysates for TLR3
- Origene Custom Protein Services for TLR3
- Sino Biological Recombinant Proteins for TLR3
- Sino Biological Cell Lysates for TLR3
-
Cloud-Clone Corp. Proteins for TLR3
- GeneTex Proteins for TLR3
-
ProSci Proteins for TLR3
-
Abcam proteins for TLR3
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for TLR3
- R&D Systems ELISAs and other biochemical assays for TLR3 (TLR3)
-
Cloud-Clone Corp. Assay Kits for TLR3
No data available for DME Specific Peptides for TLR3 Gene
Domains & Families for TLR3 Gene
Gene Families for TLR3 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for TLR3 Gene
Suggested Antigen Peptide Sequences for TLR3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O15455UniProtKB/Swiss-Prot:
TLR3_HUMAN :- ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
- Belongs to the Toll-like receptor family.
- Domain:
-
- ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR3 Gene
Molecular function for TLR3 Gene
- GENATLAS Biochemistry:
- Drosophila transmembrane receptor Toll homolog 3,with the major transcripts,predominantly expressed in placenta and pancreas,involved in immune defense
- UniProtKB/Swiss-Prot Function:
- Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Phenotypes From GWAS Catalog for TLR3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | IEA | -- |
GO:0003725 | double-stranded RNA binding | NAS | 12054664 |
GO:0004872 | receptor activity | TAS | 10426995 |
GO:0004888 | transmembrane signaling receptor activity | NAS | 12054664 |
GO:0005515 | protein binding | IPI | 16858407 |
Phenotypes for TLR3 Gene
- MGI mutant phenotypes for TLR3:
-
inferred from 3 alleles
- nervous system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- behavior/neurological phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for TLR3:
-
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Dynamic nuclei (hole, folded or small irregular)
- Strongly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased IL-8 secretion
- Increased HPV16-GFP infection
- Decreased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLR3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TLR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR3 gene
- Search ViGene Biosciences for TLR3
CRISPR Products
-
OriGene CRISPR knockouts for TLR3
- genomics-online: gRNA clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
- Applied Biological Materials CRISPR for TLR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR3
- GenScript: Design CRISPR guide RNA sequences for TLR3
miRNA for TLR3 Gene
- miRTarBase miRNAs that target TLR3
-
- hsa-mir-124-3p (MIRT022528)
- hsa-mir-758-3p (MIRT438603)
- hsa-mir-137 (MIRT564093)
- hsa-mir-92b-3p (MIRT564094)
- hsa-mir-92a-3p (MIRT564095)
- hsa-mir-367-3p (MIRT564096)
- hsa-mir-363-3p (MIRT564097)
- hsa-mir-32-5p (MIRT564098)
- hsa-mir-25-3p (MIRT564099)
- hsa-mir-3163 (MIRT564100)
- hsa-mir-365b-3p (MIRT564101)
- hsa-mir-365a-3p (MIRT564102)
- hsa-mir-3662 (MIRT564103)
- hsa-mir-548e-5p (MIRT564104)
- hsa-mir-21-5p (MIRT732464)
miRNA Products
- Search ViGene Biosciences for TLR3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TLR3
- Browse OriGene Inhibitory RNA Products For TLR3
- genomics-online: shRNA clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR3 gene
Clone Products
- Sino Biological Human cDNA Clone for TLR3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TLR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLR3
- Applied Biological Materials Clones for TLR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TLR3
Cell Line Products
-
Horizon Cell Lines for TLR3
-
ViGene Biosciences adenoviral particle packaged cDNA for TLR3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TLR3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR3 Gene
Localization for TLR3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR3 Gene
- Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005622 | intracellular | IDA | 25204797 |
GO:0005737 | cytoplasm | IDA | 19740627 |
GO:0005765 | lysosomal membrane | IDA,HDA | 17897319 |
GO:0005768 | endosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TLR3 Gene
Pathways & Interactions for TLR3 Gene
Pathways by source for TLR3 Gene
1 GeneTex pathway for TLR3 Gene
1 Cell Signaling Technology pathway for TLR3 Gene
2 BioSystems pathways for TLR3 Gene
32 Reactome pathways for TLR3 Gene
8 KEGG pathways for TLR3 Gene
1 GeneGo (Thomson Reuters) pathway for TLR3 Gene
3 R&D Systems pathways for TLR3 Gene
1 Tocris pathway for TLR3 Gene
9 Qiagen pathways for TLR3 Gene
Interacting Proteins for TLR3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001774 | microglial cell activation | IEA | -- |
GO:0001819 | positive regulation of cytokine production | IEA | -- |
GO:0001934 | positive regulation of protein phosphorylation | IEA | -- |
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002282 | microglial cell activation involved in immune response | IEA | -- |
No data available for SIGNOR curated interactions for TLR3 Gene
Drugs & Compounds for TLR3 Gene
(44) Drugs for TLR3 Gene - From: PharmGKB, ClinicalTrials, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
(5) Tocris Compounds for TLR3 Gene
Compound | Action | Cas Number |
---|---|---|
Imiquimod | Toll-like receptor 7 (TLR7) agonist | 99011-02-6 |
Pam3CSK4 | TLR1/2 agonist; induces cytokine production | 112208-00-1 |
Poly(I:C) | TLR3 agonist | 24939-03-5 |
Resiquimod | Toll-like receptor 7 (TLR7) agonist | 144875-48-9 |
RWJ 21757 | Toll-like receptor 7 (TLR7) agonist | 121288-39-9 |
(9) ApexBio Compounds for TLR3 Gene
Compound | Action | Cas Number |
---|---|---|
CU CPT 22 | 1416324-85-0 | |
CU CPT 4a | 1279713-77-7 | |
Pam2CSK4 | 868247-72-7 | |
Pam2CSK4 Biotin | ||
Pam3CSK4 | 112208-00-1 | |
Pam3CSK4 Biotin | ||
Poly(I:C) | 24939-03-5 | |
RWJ 21757 | 121288-39-9 | |
Toll-like receptor modulator | TLR antagonist | 926927-42-6 |
Transcripts for TLR3 Gene
mRNA/cDNA for TLR3 Gene
- (2) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TLR3
- genomics-online: gRNA clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
- Applied Biological Materials CRISPR for TLR3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR3
- GenScript: Design CRISPR guide RNA sequences for TLR3
miRNA Products
- Search ViGene Biosciences for TLR3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TLR3
- Browse OriGene Inhibitory RNA Products For TLR3
- genomics-online: shRNA clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR3 gene
Clone Products
- Sino Biological Human cDNA Clone for TLR3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TLR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLR3
- Applied Biological Materials Clones for TLR3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TLR3
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||
SP2: | - | ||||||||||||||||
SP3: |
Expression for TLR3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Spleen (Hematopoietic System)
- Blood (Cardiovascular System)
-
Brain (Nervous System)
- Protoplasmic Astrocyte Cells Neocortex
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
- Intestine (Gastrointestinal Tract)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLR3 Gene
NURSA nuclear receptor signaling pathways regulating expression of TLR3 Gene:
TLR3SOURCE GeneReport for Unigene cluster for TLR3 Gene:
Hs.657724mRNA Expression by UniProt/SwissProt for TLR3 Gene:
O15455-TLR3_HUMANEvidence on tissue expression from TISSUES for TLR3 Gene
- Liver(4.5)
- Lung(4.5)
- Nervous system(4.4)
- Blood(3.1)
- Spleen(3.1)
- Lymph node(2.8)
- Kidney(2.2)
- Intestine(2.1)
- Skin(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR3 Gene
- ectoderm
- mesoderm
- immune
- nervous
- brain
- head
- blood
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for TLR3
-
OriGene qPCR primer pairs and template standards for TLR3
- genomics-online: primer clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for TLR3 Gene
Orthologs for TLR3 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TLR3 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | TLR3 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | TLR3 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Tlr3 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tlr3 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TLR3 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | TLR3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TLR3 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TLR3 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tlr3 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | tlr3 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Tollo 33 |
|
||
CG9562 35 |
|
|
|||
CG5195 35 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012385 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | C56E6.6 35 |
|
|
- Species where no ortholog for TLR3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TLR3 Gene
Variants for TLR3 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TLR3 Gene
- TLR3_HUMAN-O15455
- The Phe-412 allele (dbSNP:rs3775291) occurs with a frequency of 30% in populations with European and Asian ancestry, and confers some natural resistance to HIV-1 infection.
SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs121434431 | risk-factor, Herpes simplex encephalitis 2, Herpes simplex encephalitis 2 (HSE2) [MIM:613002] | 186,083,346(+) | C/T | coding_sequence_variant, missense_variant | |
rs140712645 | likely-benign, Herpes simplex encephalitis 1 | 186,083,402(+) | C/T | coding_sequence_variant, synonymous_variant | |
rs199539539 | likely-benign, Herpes simplex encephalitis 1 | 186,076,653(+) | G/C | coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
rs35111588 | benign, Herpes simplex encephalitis 1 | 186,083,390(+) | C/T | coding_sequence_variant, synonymous_variant | |
rs35617964 | benign, Herpes simplex encephalitis 1 | 186,083,363(+) | G/A | coding_sequence_variant, synonymous_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1052e214 | CNV | gain | 21293372 |
dgv683n27 | CNV | gain | 19166990 |
dgv9426n54 | CNV | gain | 21841781 |
esv2677545 | CNV | deletion | 23128226 |
esv3603516 | CNV | gain | 21293372 |
esv3603517 | CNV | gain | 21293372 |
esv3603520 | CNV | loss | 21293372 |
esv3894090 | CNV | gain | 25118596 |
nsv1015236 | CNV | gain | 25217958 |
nsv1028146 | CNV | gain | 25217958 |
nsv1031258 | CNV | gain | 25217958 |
nsv470097 | CNV | gain | 18288195 |
Additional Variant Information for TLR3 Gene
Disorders for TLR3 Gene

(28) MalaCards diseases for TLR3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
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herpes simplex encephalitis 2 |
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human immunodeficiency virus type 1 |
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encephalitis |
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herpes simplex encephalitis |
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herpes simplex |
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UniProtKB/Swiss-Prot
TLR3_HUMAN- Herpes simplex encephalitis 2 (HSE2) [MIM:613002]: A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. {ECO:0000269 PubMed:17872438}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.
Additional Disease Information for TLR3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for TLR3 Gene
Publications for TLR3 Gene
- Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. (PMID: 18753640) Yang Z … Zhang K (The New England journal of medicine 2008) 3 4 22 44 58
- Investigation of the [-/A]8 and C1236T genetic variations within the human Toll-like receptor 3 gene for association with multiple sclerosis. (PMID: 20483009) Szvetko AL … Griffiths LR (Neurological research 2010) 3 22 44 58
- TLR3 gene polymorphisms and liver disease manifestations in chronic hepatitis C. (PMID: 19475618) Askar E … Mihm S (Journal of medical virology 2009) 3 22 44 58
- Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. (PMID: 15961631) Choe J … Wilson IA (Science (New York, N.Y.) 2005) 3 4 22 58
- TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. (PMID: 12539043) Oshiumi H … Seya T (Nature immunology 2003) 3 4 22 58
Products for TLR3 Gene
- R&D Systems Antibodies for TLR3 (TLR3)
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- R&D Systems ELISAs and other biochemical assays for TLR3 (TLR3)
- R&D Systems cDNA Clones for TLR3
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for TLR3 in any vector
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- Cell Signaling Technology (CST) Antibodies for TLR3 (TLR3)
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- Sino Biological Human cDNA Clone for TLR3
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- Novus Biologicals Antibodies for TLR3
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- Cloud-Clone Corp. Antibodies for TLR3
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for TLR3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for TLR3
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLR3
- VectorBuilder custom plasmid, inducible vectors for TLR3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TLR3
- antibodies-online: Search results for 355 available TLR3 Antibodies ranked by validation data
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- Recommended
- 191 WB Antibodies (anti-human)
- 32 FACS Antibodies (anti-human)
- 16 IHC (p) Antibodies (anti-human)
- 7 IP Antibodies (anti-human)
- 2 IF Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 134 WB Antibodies (anti-mouse)
- 25 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
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- 7 IF Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 29 WB Antibodies (anti-rat)
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- 4 FACS Antibodies (anti-rat)
- antibodies-online: Search results for 37 available TLR3 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 27 available TLR3 Proteins ranked by validation data
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- GeneTex TLR3 antibody for TLR3
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- ViGene Biosciences adenoviral particle packaged cDNA for TLR3 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for TLR3 gene
- Search ViGene Biosciences for TLR3
- Santa Cruz Biotechnology (SCBT) Antibodies for TLR3
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- Custom Antibody ServicesProSci Antibodies for TLR3
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- Horizon Cell Lines for TLR3
- genomics-online: cdna clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
- orf clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
- genomics-online: gRNA clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
- genomics-online: primer clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
- genomics-online: shRNA clones - Search results for 129 available TLR3 gene related products
- Overview of 129 available TLR3 gene related products
Sources for TLR3 Gene
- (1) GeneCards
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