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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLR3 Gene

protein-coding   GIFtS: 71
GCID: GC04P186990

Toll-Like Receptor 3

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Toll-Like Receptor 31 2
CD2832
IIAE22
CD283 Antigen3

External Ids:    HGNC: 118491   Entrez Gene: 70982   Ensembl: ENSG000001643427   OMIM: 6030295   UniProtKB: O154553   

Export aliases for TLR3 gene to outside databases

Previous GC identifers: GC04P188024 GC04P187670 GC04P187574 GC04P187686 GC04P187365 GC04P187227 GC04P182742


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR3 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly
expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It
recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of
type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation
sites to generate different length transcripts has been noted for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLR3 Gene: 
TLR3 (toll-like receptor 3) is a protein-coding gene. Diseases associated with TLR3 include herpes simplex, and herpes simplex encephalitis, and among its related super-pathways are Toll-like receptor signaling pathway and Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways. GO annotations related to this gene include double-stranded RNA binding and receptor activity. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a
nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter
TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

summary for TLR3 Gene:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR3 (TLR 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR3 gene promoter:
         AP-1   ATF-2   NF-AT   NF-AT2   POU2F1   POU2F1a   NF-AT3   STAT3   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35

TLR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P186990:  view genomic region     (about GC identifiers)

Start:
186,990,306 bp from pter      End:
187,006,255 bp from pter
Size:
15,950 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455 (See protein sequence)
Recommended Name: Toll-like receptor 3 precursor  
Size: 904 amino acids; 103829 Da
Subunit: Monomer and homodimer; dimerization is triggered by ligand-binding and is required for TLR3 signaling.
Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with TICAM1 (via the TIR domain);
mediates TLR3 signaling. Interacts with SRC; upon binding of double-stranded RNA
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane
4 PDB 3D structures from and Proteopedia for TLR3:
1ZIW (3D)        2A0Z (3D)        3ULU (3D)        3ULV (3D)    
Secondary accessions: Q4VAL2

Explore the universe of human proteins at neXtProt for TLR3: NX_O15455

Explore proteomics data for TLR3 at MOPED 

Post-translational modifications:

  • UniProtKB: Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15455

  • TLR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLR3 Protein Expression
    REFSEQ proteins: NP_003256.1  
    ENSEMBL proteins: 
     ENSP00000296795   ENSP00000423386   ENSP00000423684  
    Reactome Protein details: O15455
    Human Recombinant Protein Products for TLR3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for TLR3
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TLR3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TLR3
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    Novus Biologicals TLR3 Proteins
    Novus Biologicals TLR3 Lysate
    Sino Biological Recombinant Protein for TLR3
    Sino Biological Cell Lysate for TLR3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR3 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005737cytoplasm IDA19740627
    GO:0005765lysosomal membrane IDA17897319
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005887integral to plasma membrane TAS9435236

    TLR3 for ontologies           About GeneDecksing



    TLR3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TLR3
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    Novus Biologicals TLR3 Antibodies
    Abcam antibodies for TLR3
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    ThermoFisher Antibody for TLR3
    LSBio Antibodies in human, mouse, rat for TLR3 

    Assay Products for TLR3: 
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    Cloud-Clone Corp. ELISAs for TLR3 
    Cloud-Clone Corp. CLIAs for TLR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR3 
    Toll-like receptor family

    5/6 InterPro protein domains (see all 6):
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR027173 TLR3

    Graphical View of Domain Structure for InterPro Entry O15455

    ProtoNet protein and cluster: O15455

    4 Blocks protein domains:
    IPB000157 TIR domain
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
    Domain: ds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18 (By similarity)
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 22 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain
    Similarity: Contains 1 TIR domain


    TLR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR3_HUMAN, O15455
    Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response
    against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a
    nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter
    TRIF/TICAM1, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response

         Genatlas biochemistry entry for TLR3:
    Drosophila transmembrane receptor Toll homolog 3,with the major transcripts,predominantly expressed in placenta
    and pancreas,involved in immune defense

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding NAS12054664
    GO:0004872receptor activity TAS10426995
    GO:0004888transmembrane signaling receptor activity NAS12054664
    GO:0005515protein binding IPI16858407
         
    TLR3 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tlr3):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  homeostasis/metabolism  immune system 
     mortality/aging  muscle  nervous system  reproductive system  respiratory system 
     tumorigenesis 

    TLR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TLR3: Tlr3tm1Flv Tlr3tm1Ttg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR3 

    miRNA
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    Inhib. RNA
    Products:
        
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    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of TLR3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: TLR3 (NM_003265)
    Sino Biological Human cDNA Clone for TLR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR3
    Sirion Biotech Customized lentivirus for stable overexpression of TLR3 
                         Customized lentivirus expression plasmids for stable overexpression of TLR3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLR3 About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
    Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway0.91
    Immune response Role of TLRs 3 and 4 in cell antiviral response: TICAM1-specific signaling pathways0.91
    3TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    4TRAF6 mediated induction of TAK1 complex
    TRAF6 mediated induction of TAK1 complex0.56
    IKK complex recruitment mediated by RIP10.42
    Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon0.50
    TRIF-mediated programmed cell death0.32
    5Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52
    NOD-like Receptor Signaling Pathways0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TLR3
        Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways

    5/6 R&D Systems Pathways for TLR3 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR3 (see all 9)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR3
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR3
        Toll-like Receptor Pathway

    1 GeneGo (Thomson Reuters) Pathway for TLR3
        Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway

    1 BioSystems Pathway for TLR3
        Toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR3 
        NF-kB (NFkB) Pathway

    5/13        Reactome Pathways for TLR3 (see all 13)
        IKK complex recruitment mediated by RIP1
    Toll Like Receptor 4 (TLR4) Cascade
    Toll-Like Receptors Cascades
    TRIF-mediated programmed cell death
    Toll Like Receptor 3 (TLR3) Cascade


    5         Kegg Pathways  (Kegg details for TLR3):
        Toll-like receptor signaling pathway
    Hepatitis C
    Hepatitis B
    Influenza A
    Herpes simplex infection


    TLR3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for TLR3 (O154552, 3 ENSP000002967954) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-2840093 MINT-2840114 I2D: score=2 STRING: ENSP00000274335
    ENSG00000184494Q995193I2D: score=1 
    ENSG00000223957Q995193I2D: score=1 
    ENSG00000227129Q995193I2D: score=1 
    ENSG00000227315Q995193I2D: score=1 
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006952defense response ----
    GO:0006954inflammatory response IEA--
    GO:0006972hyperosmotic response NAS12054664

    TLR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TLR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TLR3

    Compounds for TLR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Pam2CSK4TLR2/6 agonist; induces TNF-alpha production[868247-72-7]
    ResiquimodToll-like receptor 7 (TLR7) agonist[144875-48-9]
    Pam3CSK4TLR1/2 agonist; induces cytokine production[112208-00-1]
    Poly(I:C)TLR3 agonist[42424-50-0]
    ImiquimodToll-like receptor 7 (TLR7) agonist[99011-02-6]

    1 IUPHAR Ligand for TLR3 (TLR3)    About this table 
    LigandTypeActionAffinityPubmed IDs
    polyIC
    AgonistAgonist11607032

    10/22 Novoseek inferred chemical compound relationships for TLR3 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly(i-c) 92.4 66 16384532 (3), 15845391 (3), 16142732 (3), 14688319 (2) (see all 38)
    polyinosinic-polycytidylic acid 92.1 72 17962643 (4), 19452017 (4), 19154402 (2), 18949355 (2) (see all 36)
    flagellin 77 14 16365459 (1), 19294011 (1), 19955831 (1), 19740321 (1) (see all 14)
    inosine monophosphate 74.2 13 17182588 (3), 17573354 (1), 18715647 (1), 15196204 (1) (see all 11)
    peptidoglycan 68.8 16 16365459 (1), 17114468 (1), 16670332 (1), 14996826 (1) (see all 12)
    rantes 67.9 14 19121387 (3), 19452017 (2), 16436653 (1), 14517278 (1) (see all 9)
    lipoteichoic acid 58.1 4 17114468 (1), 15652398 (1), 16052591 (1), 16175622 (1)
    tab-2 52.8 3 14982987 (2), 12609980 (1)
    2',5'-oligoadenylate 52.8 2 17669408 (1)
    imiquimod 51.6 2 19578865 (1), 19643938 (1)

    1 PharmGKB related drug/compound annotation for TLR3 gene    About this table
    Drug/compound PharmGKB Annotation
    Measles vaccinesCA  

    Search CenterWatch for drugs/clinical trials and news about TLR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLR3 gene: 
    NM_003265.2  

    Unigene Cluster for TLR3:

    Toll-like receptor 3
    Hs.657724  [show with all ESTs]
    Unigene Representative Sequence: BC068487
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296795(uc003iyq.3) ENST00000513189 ENST00000512264(uc011ckz.2 uc003iyr.3)
    ENST00000504367 ENST00000508051
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector: TLR3 (NM_003265)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR3
    Sirion Biotech Customized lentivirus for stable overexpression of TLR3 
                         Customized lentivirus expression plasmids for stable overexpression of TLR3 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR3

    Additional mRNA sequence: 

    AB445631.1 AK302143.1 AK314208.1 BC017954.1 BC043204.2 BC059372.1 BC068487.1 BC094737.1 
    BC096333.1 BC096334.3 BC096335.1 DQ445682.1 DQ470075.1 DQ470076.1 DQ470077.1 DQ470078.1 
    DQ470079.1 U88879.1 

    4 DOTS entries:

    DT.109361  DT.100664575  DT.101977909  DT.99984982 

    24/50 AceView cDNA sequences (see all 50):

    AU135937 BC068487 NM_003265 CF528559 BQ007482 CF529473 BX104394 BU624267 
    BX489646 CF994731 CB988158 BC043204 BU950410 CF994235 BX489678 BU853465 
    BF971051 BU929797 CB960574 CD109430 BC059372 BG573455 BF594247 CB989983 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TLR3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6
    SP1:                    -     -                           
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for TLR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLR3 expression in normal human tissues (normalized intensities)      TLR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCTGTTT
    TLR3 Expression
    About this image


    TLR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             ileum   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Lung (Respiratory System)
             trachea   
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen

    See TLR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLR3

    SOURCE GeneReport for Unigene cluster: Hs.657724

    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
    Tissue specificity: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic
    cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the
    TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR3 (see all 8): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TLR3 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr31 , 5 toll-like receptor 31, 5 81.31(n)1
    79.93(a)1
      8 (25.31 cM)5
    1429801  NM_126166.41  NP_569054.21 
     453956655 
    chicken
    (Gallus gallus)
    Aves TLR31 toll-like receptor 3 67.01(n)
    62.06(a)
      422720  NM_001011691.3  NP_001011691.3 
    lizard
    (Anolis carolinensis)
    Reptilia TLR36
    --
    Uncharacterized protein
    58(a)
    24(a)
    1 ↔ 1
    possible ortholog
    5(112305568-112319535)
    2(122504100-122506901)
    zebrafish
    (Danio rerio)
    Actinopterygii tlr31 toll-like receptor 3 52.99(n)
    49.2(a)
      403126  NM_001013269.2  NP_001013287.2 


    ENSEMBL Gene Tree for TLR3 (if available)
    TreeFam Gene Tree for TLR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLR3 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR92  TLR52  TLR102  TLR42  
    TLR82  TLR62  TLR22  
    2 SIMAP similar genes for TLR3 using alignment to 7 protein entries:     TLR3_HUMAN (see all proteins):
    TLR2    TLR10

    TLR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
    Polymorphism: The Phe-412 allele (dbSNP:rs3775291) occurs with a frequency of 30% in populations with European and
    Asian ancestry, and confers some natural resistance to HIV-1 infection


    10/466 SNPs in TLR3 are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0548874
    Herpes simplex encephalitis 2 (HSE2)4--see VAR_0548872 P S mis40--------
    rs1214344311,2
    C,Fother1186763303(+) GTGGTC/TCCATT 2 P S mis11Minor allele frequency- T:0.00NA 4550
    rs360276241,2
    C--182754573(+) AAAAA-/A/AA  
            
    AAAAA
    1 -- int12NA CSA 4
    rs1153135991,2
    C,F--186747149(+) GGACTC/GAAGTG 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1395076741,2
    --186747253(+) ACCACA/GTTGCC 1 -- us2k10--------
    rs1455860231,2
    --186747290(+) AAGCAA/GTCTCC 1 -- us2k10--------
    rs752174671,2
    C,F--186747300(+) CTAAAG/ATGTTG 1 -- us2k12Minor allele frequency- A:0.09CSA WA 120
    rs1829287491,2
    --186747430(+) AATGTA/GCAGTA 1 -- us2k10--------
    rs1477253781,2
    --186747470(+) AACTAA/GCAAGA 1 -- us2k10--------
    rs1870450181,2
    --186747588(+) AAGTCA/GTGGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLR3 (186990306 - 187006255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TLR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677545CNV Deletion23128226
    dgv683n27CNV Gain19166990
    nsv470097CNV Gain18288195
    dgv5852n71CNV Gain21882294
    nsv881424CNV Gain21882294
    dgv5851n71CNV Gain21882294


    Human Gene Mutation Database (HGMD): TLR3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR3
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603029   
    OMIM disorders: 613002  
    UniProtKB/Swiss-Prot: TLR3_HUMAN, O15455
  • Herpes simplex encephalitis 2 (HSE2) [MIM:613002]: A rare complication of human herpesvirus 1 (HHV-1)
    infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic
    necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache,
    seizures, stupor, and often coma, frequently with a fatal outcome. Note=Disease susceptibility is associated with
    variations affecting the gene represented in this entry. TLR3 mutations predispose otherwise healthy individuals
    to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced
    immune defense against viral infection in the central nervous system

  • 20/94 diseases for TLR3 (see all 94):    About MalaCards
    herpes simplex    herpes simplex encephalitis    encephalitis    measles
    west nile virus    allergic conjunctivitis    septic arthritis    molluscum contagiosum
    subacute sclerosing panencephalitis    protein c deficiency    stevens-johnson syndrome    hyper ige syndrome
    tick-borne encephalitis    influenza    bronchiolitis    bronchiolitis obliterans
    pandas    biliary atresia    rubella    hepatitis a

    5 diseases from the University of Copenhagen DISEASES database for TLR3:
    Encephalitis     Melanoma     Influenza     Herpes simplex
    Asthma

    TLR3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/29 Novoseek inferred disease relationships for TLR3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 73.1 57 16877304 (2), 14575692 (2), 19452017 (2), 12672806 (2) (see all 36)
    inflammation 48.6 13 19752565 (2), 20387535 (2), 18403353 (1), 20483774 (1) (see all 9)
    hepatitis c chronic 38.3 1 19475618 (1)
    necrosis 32.7 9 14729660 (1), 15579900 (1), 16510559 (1), 18765427 (1) (see all 9)
    melanoma 32.1 27 17671143 (4), 19001446 (3), 19470740 (2), 17142768 (1) (see all 14)
    hepatitis c 30.8 3 19625408 (2), 18021446 (1)
    influenza 30.4 10 15579900 (3), 19231996 (3), 16399790 (2), 16517210 (1) (see all 5)
    bacterial infections 27.2 1 18083507 (1)
    herpes simplex 23.9 3 19025601 (1), 16847112 (1)
    pouchitis 20.9 3 16770571 (2)

    Genetic Association Database (GAD): TLR3
    Human Genome Epidemiology (HuGE) Navigator: TLR3 (55 documents)

    Export disorders for TLR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLR3 gene, integrated from 9 sources (see all 665):
    (articles sorted by number of sources associating them with TLR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. (PubMed id 18753640)1, 2, 4, 9 Yang Z.... Zhang K. (2008)
    2. A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)1, 2, 3 Rock F.L.... Bazan J.F. (1998)
    3. TLR3 gene polymorphisms and liver disease manifestati ons in chronic hepatitis C. (PubMed id 19475618)1, 4, 9 Askar E....Mihm S. (2009)
    4. Investigation of the [-/A]8 and C1236T genetic variat ions within the human Toll-like receptor 3 gene for association with multiple s clerosis. (PubMed id 20483009)1, 4, 9 Szvetko A.L....Griffiths L.R. (2010)
    5. Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. (PubMed id 15961631)1, 2, 9 Choe J....Wilson I.A. (2005)
    6. Single-nucleotide polymorphisms in genes encoding tol l-like receptor -2, -3, -4, and -9 in case-control study with breast cancer. (PubMed id 19810822)1, 4, 9 Etokebe G.E....DembiA8 Z. (2009)
    7. Toll-like receptor polymorphisms and age-related macular degeneration. (PubMed id 18385087)1, 4, 9 Edwards A.O....Tosakulwong N. (2008)
    8. Polymorphisms in toll-like receptor 4 and toll-like r eceptor 9 influence viral load in a seroincident cohort of HIV-1-infected indiv iduals. (PubMed id 19855253)1, 4, 9 Pine S.O....Bochud P.Y. (2009)
    9. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. (PubMed id 18946062)1, 4, 9 Bochud P.Y....Boeckh M. (2008)
    10. Innate immunity of the ocular surface and ocular surface inflammatory disorders. (PubMed id 18813073)1, 4, 9 Ueta M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7098 HGNC: 11849 AceView: TLR3 Ensembl:ENSG00000164342 euGenes: HUgn7098
    ECgene: TLR3 Kegg: 7098 H-InvDB: TLR3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLR3 Pharmacogenomics, SNPs, Pathways
    TLR3basehttp://bioinf.uta.fi/TLR3base/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLR3 gene:
    Search GeneIP for patents involving TLR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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