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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TLR2 Gene

protein-coding GIFtS: 69
GCID: GC04P154612

toll-like receptor 2

Explore 206 diseases affiliated with
TLR2 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Toll-Like Receptor 2¹ ²
TIL4¹ ² ³ ⁵
CD282¹ ²
Toll/Interleukin-1 Receptor-Like Protein 4² ³
Toll/Interleukin 1 Receptor-Like 4²
CD282 Antigen³

External Ids:	HGNC: 11848¹	Entrez Gene: 7097²	Ensembl: ENSG00000137462⁷	OMIM: 603028⁵	UniProtKB: O60603³

Export aliases for TLR2 gene to outside databases

Previous GC identifers: GC04P155458 GC04P154997 GC04P155183 GC04P155186 GC04P154966 GC04P154824 GC04P154606 GC04P150336

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR2:

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in

pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share

structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are

expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective

immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in

peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of

NF-kappaB. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603

Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell

wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or

lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory

response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating

lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer

surface protein A lipoprotein (OspA-L) cooperatively with TLR6

summary for TLR2:

Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the

innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been

reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like

receptors are activated by molecules associated with biological threat and are highly specific towards

evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella

and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous

ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor

activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates

downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which

converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This

can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to

toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR2 (TLR 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TLR2 gene promoter:
AP-1 ATF-2 CREB PPAR-gamma1 deltaCREB STAT3 IRF-7A PPAR-gamma2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLR2 promoter sequence

Search SABiosciences Chromatin IP Primers for TLR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32 Ensembl cytogenetic band: 4q31.3 HGNC cytogenetic band: 4q32

TLR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR2 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P154612: view genomic region (about GC identifiers)

Start:	154,605,441 bp from pter	End:	154,627,243 bp from pter
Size:	21,803 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603 (See protein sequence)

Recommended Name: Toll-like receptor 2 precursor

Size: 784 amino acids; 89838 Da

Subunit: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with

TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3 (By similarity).

Interacts with ATG16L1

Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)

5 PDB 3D structures from and Proteopedia for TLR2:

1FYW (3D)

1FYX (3D)

1O77 (3D)

2Z7X (3D)

2Z80 (3D)

Secondary accessions: B3Y612 D1CS45 D1CS48 D1CS49 O15454 Q8NI00

Explore the universe of human proteins at neXtProt for TLR2: NX_O60603

Post-translational modifications:

Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60603

TLR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003255.2

ENSEMBL proteins:

ENSP00000260010

Reactome Protein details: O60603
Human Recombinant Protein Products for TLR2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TLR2
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	OriGene Purified Protein: TLR2 OriGene Protein Over-expression Lysate: TLR2 OriGene Custom Protein Services for TLR2
	GenScript Custom Purified and Recombinant Proteins Services for TLR2
	Novus Biologicals TLR2 Proteins Novus Biologicals TLR2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TLR2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	19740627
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9435236
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	IDA	12443841

TLR2 for ontologies About GeneDecksing

TLR2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TLR2
	R&D Systems Antibodies for TLR2
	Cell Signaling Technology (CST) Antibodies for TLR2
	OriGene Antibodies (see all 3): TLR2 OriGene Custom Antibody Services for TLR2
	GenScript Custom Superior Antibodies Services for TLR2
	Novus Biologicals TLR2 Antibodies
	Abcam antibodies for TLR2
	Uscn Antibodies for TLR2
	ThermoFisher Antibody for TLR2

Assay Products for TLR2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for TLR2 (see all)
	GenScript Custom Assay Services for TLR2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TLR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TLR2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000483 Cys-rich_flank_reg_C

IPR001611 Leu-rich_rpt

IPR000157 TIR_dom

IPR017241 Toll-like_receptor

IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry O60603

ProtoNet protein and cluster: O60603

3 Blocks protein families:

IPB000157 TIR domain

IPB000483 Cysteine-rich flanking region

IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603

Domain: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12 (By similarity)

Domain: The ATG16L1-binding motif mediates interaction with ATG16L1 (PubMed:23376921)

Similarity: Belongs to the Toll-like receptor family

Similarity: Contains 19 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 TIR domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TLR2_HUMAN, O60603

Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell

wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or

lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory

response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating

lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer

surface protein A lipoprotein (OspA-L) cooperatively with TLR6

Genatlas biochemistry entry for TLR2:

Drosophila transmembrane receptor Toll homolog 2,with two alternatively spliced isoforms,one expressed in lung,the

other in heart,brain,muscle,mediator of liposaccharide (LPS) considered as a receptor,induced cellular

signaling,involved in innate immunity through the recruitment of MYD88,against Gram positive bacteria

Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001875	lipopolysaccharide receptor activity	TAS	11518816
GO:0004872	receptor activity	IDA	11672593
GO:0004888	transmembrane signaling receptor activity	IEA	--
GO:0005515	protein binding	IPI	19509286
GO:0008329	pattern recognition receptor activity	IDA	10384090

TLR2 for ontologies About GeneDecksing

Phenotypes:
15/21 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tlr2) (see all 21):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	liver/biliary system	mortality/aging	muscle	nervous system

TLR2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for TLR2: Tlr2^tm1Kir Tlr2^tm1Dgen Tlr2^tm1Aki

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TLR2

miRNA Products:		miRTarBase miRNAs that target TLR2: hsa-mir-105 (MIRT001127), hsa-mir-146a (MIRT000449)

		OriGene 3'-UTR Clone: TLR2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLR2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TLR2:
		hsa-miR-579 hsa-miR-548v
		SwitchGear 3'UTR luciferase reporter plasmid: TLR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR2 (see all 7) OriGene shRNA RFP: TLR2 OriGene siRNA: TLR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR2
		Sirion Biotech Custom design and validation of potent shRNA sequences against TLR2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TLR2
			Sirion Biotech Customized adenovirus for overexpression of TLR2 Sirion Biotech Customized adenovirus for potent knockdown of TLR2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TLR2 (NM_003264)
		Sino Biological Human cDNA Clone for TLR2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TLR2
		Search LifeMap BioReagents cell lines for TLR2
		Sirion Biotech Customized stable knockdown cell line services for TLR2 Sirion Biotech Customized inducible knockdown cell line services for TLR2 Sirion Biotech Customized stable overexpressing cell line services for TLR2 Sirion Biotech Customized inducible overexpressing cell line services for TLR2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

Toll Like Receptor TLR1:TLR2 Cascade	0.78	Activated TLR4 signalling	0.63
Toll Like Receptor TLR6:TLR2 Cascade	0.78	Toll Like Receptor 4 (TLR4) Cascade	0.61
Toll Like Receptor 2 (TLR2) Cascade	0.78	Toll-Like Receptors Cascades	0.53
MyD88:Mal cascade initiated on plasma membrane	0.78

Toll-like receptor signaling pathway

Toll-like receptor signaling pathway	1.00	Chagas disease (American trypanosomiasis)	0.31
Toll-like receptor signaling pathway	0.97	Inflammasome Activation Pathways	0.29
Toll-Like receptor Signaling Pathways	0.51

Immune response_Bacterial infections in normal airways

Immune response_Bacterial infections in normal airways

1.00

Bacterial infections in CF airways

0.78

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

1.00

Mucin expression in CF via TLRs, EGFR signaling pathways

0.41

Immune System

Immune System

1.00

Innate Immune System

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for TLR2

	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
	Selected targets of GCR-alpha

5 R&D Systems Pathways for TLR2

	Inflammasome Activation Pathways
	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways
	Th17 Differentiation

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR2 (see all 11)

	MSP-RON Signaling
	NF-KappaB (p50-p65) Pathway
	Toll-Like Receptors Pathway
	TRAF Pathway
	NTHi-Induced Signaling

1 Cell Signaling Technology (CST) Pathway for TLR2

NF-kappaB Signaling

1 Tocris Bioscience Pathway for TLR2

Toll-like Receptor Pathway

5 GeneGo (Thomson Reuters) Pathways for TLR2

	Mucin expression in CF via TLRs, EGFR signaling pathways
	Immune response Bacterial infections in normal airways
	Immune response TLR signaling pathways
	Bacterial infections in CF airways
	Mucin expression in CF via IL-6, IL-17 signaling pathways

1 BioSystems Pathway for TLR2

Toll-like receptor signaling pathway

5/11 Reactome Pathways for TLR2 (see all 11)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor 4 (TLR4) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades
	Defensins

5/10 Kegg Pathways (Kegg details for TLR2) (see all 10):

	Phagosome
	Toll-like receptor signaling pathway
	Leishmaniasis
	Chagas disease (American trypanosomiasis)
	Malaria

TLR2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TLR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for TLR2 (O60603^{1, 2, 3} ENSP00000260010⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986²^,³, ENSP00000274335⁴	MINT-8402469 I2D: score=3 STRING: ENSP00000274335
MYD88	Q99836²^,³, ENSP00000379625⁴	MINT-3981836 I2D: score=6 STRING: ENSP00000379625
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-3981822 I2D: score=2 STRING: ENSP00000275493
IRAK1	P51617³, ENSP00000358997⁴	I2D: score=5 STRING: ENSP00000358997
HRAS	P01112³, ENSP00000309845⁴	I2D: score=3 STRING: ENSP00000309845

About this table

Gene Ontology (GO): 5/50 biological process terms (GO ID links to tree view) (see all 50): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002221	pattern recognition receptor signaling pathway	--	--
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002238	response to molecule of fungal origin	IEA	--
GO:0002687	positive regulation of leukocyte migration	IEA	--
GO:0002752	cell surface pattern recognition receptor signaling pathway	IEA	--

TLR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TLR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TLR2 available from Tocris Bioscience About this table

Compound	Action	CAS #
GIT 27	Immunomodulator; reduces production of pro-inflammatory cytokines	[6501-72-0]

2 DrugBank Compounds for TLR2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
S-(Dimethylarsenic)Cysteine	--	--	target	--	17139284 17016423
OspA lipoprotein	--	--	target	other/unknown	14617145

10/88 Novoseek chemical compound relationships for TLR2 gene (see all 88) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipoteichoic acid	90.7	191	10364168 (4), 12011760 (4), 18458151 (4), 12691617 (3) (see all 75)
peptidoglycan	87.1	257	12874299 (6), 20118281 (5), 11292690 (4), 16239565 (4) (see all 99)
loxoribine	75.5	4	17899542 (1), 17853407 (1), 15749901 (1), 15804290 (1)
hbd2	74.1	10	18219831 (2), 16242370 (1), 15854033 (1), 17241164 (1) (see all 8)
flagellin	73.8	30	16365459 (1), 16319082 (1), 16982839 (1), 19121068 (1) (see all 28)
muramyl dipeptide	71.3	5	12537692 (1), 15617523 (1), 15839897 (1), 16299289 (1)
poly(i-c)	65.8	7	16484229 (1), 16365459 (1), 16670332 (1), 16052591 (1) (see all 7)
p3c-sk4	65.6	2	17662043 (1), 16412017 (1)
endotoxin	61.5	28	12717397 (3), 16428799 (2), 10358136 (2), 10878331 (1) (see all 21)
zymosan	60.1	16	12225373 (2), 19888805 (2), 12817025 (2), 19846883 (2) (see all 11)

Search CenterWatch for drugs/clinical trials and news about TLR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TLR2 gene:

NM_003264.3

Unigene Cluster for TLR2:

Toll-like receptor 2

Hs.519033 [show with all ESTs]

Unigene Representative Sequence: AK125659

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000260010(uc021xtl.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLR2
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		hsa-miR-579 hsa-miR-548v
		SwitchGear 3'UTR luciferase reporter plasmid: TLR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLR2 (see all 7) OriGene shRNA RFP: TLR2 OriGene siRNA: TLR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLR2
		Sirion Biotech Custom design and validation of potent shRNA sequences against TLR2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLR2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLR2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TLR2 (NM_003264)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TLR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLR2

Additional cDNA sequence:

AB445624.1 AF051152.1 AF424049.1 AF424050.1 AF424051.1 AF424052.1 AF424053.1 AF502291.1

AK125659.1 BC033756.1 DQ012265.1 DQ012266.1 DQ012267.1 DQ012268.1 DQ012269.1 DQ012270.1

DQ012271.1 U88878.1

5 DOTS entries:

DT.212665 DT.100025207 DT.95146205 DT.121241774 DT.95266498

24/67 AceView cDNA sequences (see all 67):

AW236149 BU738748 BX095256 C01647 CD367547 AW206320 BC033756 U88878

AF424053 BI769109 CA448548 AA075065 NM_003264 CA306889 AF424051 BM713905

AF424049 BQ083606 CB162652 AI492029 AA075066 CA748556 AI017157 AF424052

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TLR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACGAGGCTC

About this image
See TLR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLR2

SOURCE GeneReport for Unigene cluster: Hs.519033

UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603

Tissue specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph

node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including TLR2 (see all 11):

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T-cell & B-cell Activation in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Antibacterial Response in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TLR2 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1P5J3_CHICK⁶ TLR21_CHICK⁶ (see all 3)	Toll-like receptor 2 type-1 (see all 3)	53(a) 52(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	4(21113342-21115936) 4(21101221-21108622)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	50(a) 49(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	5(130808868-130811195) 5(130977063-130980503)
zebrafish (Danio rerio)	Actinopterygii	tlr2¹	toll-like receptor 2	50.99(n) 43.68(a)		403125 NM_212812.1 NP_997977.1
fruit fly (Drosophila melanogaster)	Insecta	Tehao⁶ Tl⁶ (see all 5)	Toll (see all 5)	15(a) 13(a) (see all 5)	possible ortholog possible ortholog (see all 5)	2L(13435622-13439333) 3R(22624765-22668125)

ENSEMBL Gene Tree for TLR2 (if available)
TreeFam Gene Tree for TLR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TLR2 gene

CD180² ENSG00000173366² TLR7² TLR1² TLR9² TLR5² TLR10² LRRC33²

TLR4² TLR8² TLR6² LRRC32² TLR3²

4 SIMAP similar genes for TLR2 using alignment to 8 protein entries: TLR2_HUMAN (see all proteins):

TLR3 TLR1 TLR6 TLR10

TLR2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TLR2
PGOHUM00000246105

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603

Polymorphism: Genetic variations in TLR2 are associated with susceptibility to leprosy [MIM:246300]. Leprosy is a

chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower

temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677

polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2

mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677

polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor

cellular immune response associated with lepromatous leprosy

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137853177^1,2	C,F	untested	150356990(+)	`CTCCCA/CGCAGG`	2	S R	mis¹		1		NA	4528
rs121917864^1,2	C	other	150357113(+)	`ATAAGC/TGGGAC`	2	R W	mis¹		0	--	--	--	--
rs78952531^1,2	F	--	150334510(+)	`CTAGAT/AGTGAA`	1	--	us2k¹		1		WA	118
rs112432815^1,2		--	150334735(+)	`GAGAAC/TTGCTT`	1	--	us2k¹		1		CSA	2
rs72731632^1,2	C	--	150335293(+)	`GTTCCA/GACCAT`	1	--	us2k¹		0	--	--	--	--
rs2099683^1,2	C,H	--	150335749(+)	`GGTGCA/CCCAGT`	1	--	us2k¹		6		NS EA NA	416
rs75489577^1,2	F	--	150335769(+)	`CACTGG/TATTGG`	1	--	us2k¹		1		EA	120
rs77521392^1,2	C,F	--	150335810(+)	`TCCCTT/CAGGCA`	1	--	us2k¹		1		NA	120
rs112009616^1,2		--	150335898(+)	`TGGAGT/ATGTAC`	1	--	us2k¹		1		CSA	1
rs79620165^1,2	C	--	150335987(+)	`GAAAAG/ACATCA`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for TLR2 (154605441 - 154627243 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TLR2
1 CNV: 0051
Human Gene Mutation Database (HGMD): TLR2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TLR2 for disorders           About GeneDecksing

OMIM gene information: 603028
OMIM disorders: 246300  114500
20/206 diseases for TLR2 (see all 206):    About MalaCards

endotoxin hyporesponsiveness b-cell non-hodgkin lymphoma hyper-ige syndrome hypersensitivity reaction type ii disease

mycobacterium abscessus non-hodgkin lymphoma otitis media burning mouth syndrome

mycobacterial infection lichen planus aortic valve stenosis oral lichen planus

pre-eclampsia lepromatous leprosy familial mediterranean fever systemic lupus erythematosus

malt lymphoma bacterial vaginosis ectopic pregnancy allergic rhinitis

15 diseases from the University of Copenhagen DISEASES database for TLR2:

Tuberculosis Periodontitis Lyme disease Pneumonia

Arthritis Tularemia Atherosclerosis Inflammatory bowel disease

Meningitis Asthma Leprosy Hypersensitivity reaction type I disease

Atopic dermatitis Mastitis Otitis media

10/96 Novoseek disease relationships for TLR2 gene (see all 96) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	70.6	97	18202345 (3), 19479087 (3), 19948979 (2), 19608024 (2) (see all 71)
necrosis	67.2	106	15345653 (2), 16970685 (2), 12089142 (2), 15242847 (2) (see all 85)
gram-positive bacterial infections	59.5	4	17456342 (1), 18424724 (1)
bacterial infections	58.9	20	12853386 (3), 17437421 (2), 17889686 (2), 20402597 (1) (see all 15)
tuberculosis	56.2	92	19552525 (5), 15322009 (3), 16365150 (3), 19686607 (3) (see all 54)
mycobacterial infection	55.4	14	12646604 (1), 15270740 (1), 14687934 (1), 17056554 (1) (see all 8)
sepsis	53.8	86	17456342 (7), 15086396 (7), 15489631 (5), 19371402 (4) (see all 27)
chronic periodontitis	52.8	10	20233331 (2), 17176826 (2), 17956467 (2), 16274315 (1) (see all 7)
shock septic	50.5	7	16878028 (1), 18302745 (1), 16670636 (1), 11035751 (1) (see all 7)
leprosy lepromatous	45.2	12	15270740 (2), 12445799 (2), 12646604 (1), 12743710 (1) (see all 7)

Genetic Association Database (GAD): TLR2
Human Genome Epidemiology (HuGE) Navigator: TLR2 (236 documents)

Export disorders for TLR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TLR2 gene, integrated from 9 sources (see all 1781):
(articles sorted by number of sources associating them with TLR2)

Utopia: connect your pdf to the dynamic
world of online information

A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)^{1, 2, 3} Rock F.L.... Bazan J.F. (1998)
A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy. (PubMed id 12445799)^{1, 4, 9} Kang T.J....Chae G.T. (2002)
Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. (PubMed id 9596645)^{1, 2, 9} Chaudhary P.M.... Nelson P.S. (1998)
Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. (PubMed id 11476982)^{1, 2, 9} Kang T.-J. and Chae G.-T. (2001)
Toll-like receptor 2 as a major gene for asthma in children of European farmers. (PubMed id 15007351)^{1, 4, 9} Eder W....Martinez F.D. (2004)
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. (PubMed id 17889651)^{1, 2, 9} Jin M.S....Lee J.-O. (2007)
Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. (PubMed id 16374251)^{1, 4, 9} Pierik M....Vermeire S. (2006)
TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. (PubMed id 15968536)^{1, 4, 9} Berdeli A....Aydin H.H. (2005)
A frequent toll-like receptor (TLR)-2 polymorphism is a risk factor for coronary restenosis. (PubMed id 15875151)^{1, 4, 9} Hamann L....Schumann R.R. (2005)
TLR2 Arg677Trp polymorphism in leprosy: revisited. (PubMed id 15726416)^{1, 4, 9} Malhotra D....Bamezai R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7097	HGNC: 11848	AceView: TLR2	Ensembl:ENSG00000137462	euGenes: HUgn7097
ECgene: TLR2	Kegg: 7097	H-InvDB: TLR2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TLR2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TLR2 gene
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GeneCards and IP:
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toll-like receptor 2

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Anaplasmosis
Bronchiectasis
Measles
Leprosy Lepromatous
sepsis
Malaria
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allergy
Skin Diseases
Atherosclerosis
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ASPERGILLOSIS INVASIVE
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INFECTION FUNGAL
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restenosis
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TLR2 Gene

toll-like receptor 2

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