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TLR2 Gene

protein-coding   GIFtS: 70
GCID: GC04P154612

Toll-Like Receptor 2

  See TLR2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Toll-Like Receptor 21 2
TIL42 3 5
Toll/Interleukin-1 Receptor-Like Protein 42 3
CD2822
Toll/Interleukin 1 Receptor-Like 42
CD282 Antigen3

External Ids:    HGNC: 118481   Entrez Gene: 70972   Ensembl: ENSG000001374627   OMIM: 6030285   UniProtKB: O606033   

Export aliases for TLR2 gene to outside databases

Previous GC identifers: GC04P155458 GC04P154997 GC04P155183 GC04P155186 GC04P154966 GC04P154824 GC04P154606 GC04P150336


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLR2 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most
abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via
stimulation of NF-kappaB. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLR2 Gene:
TLR2 (toll-like receptor 2) is a protein-coding gene. Diseases associated with TLR2 include enthesitis-related arthritis, and rheumatic fever. GO annotations related to this gene include transmembrane signaling receptor activity and protein heterodimerization activity. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603
Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial
cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial
lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and
the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal
macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM)
and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6

summary for TLR2 Gene:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR2 (TLR 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLR2 gene promoter:
         AP-1   ATF-2   CREB   PPAR-gamma1   deltaCREB   STAT3   IRF-7A   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR2 promoter sequence
   Search Chromatin IP Primers for TLR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q32

TLR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P154612:  view genomic region     (about GC identifiers)

Start:
154,605,441 bp from pter      End:
154,627,243 bp from pter
Size:
21,803 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603 (See protein sequence)
Recommended Name: Toll-like receptor 2 precursor  
Size: 784 amino acids; 89838 Da
Subunit: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts
with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3 (By
similarity). Interacts with ATG16L1
5 PDB 3D structures from and Proteopedia for TLR2:
1FYW (3D)        1FYX (3D)        1O77 (3D)        2Z7X (3D)        2Z80 (3D)    
Secondary accessions: B3Y612 D1CS45 D1CS48 D1CS49 O15454 Q8NI00

Explore the universe of human proteins at neXtProt for TLR2: NX_O60603

Explore proteomics data for TLR2 at MOPED

Post-translational modifications: 

  • Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR21
  • Glycosylation2 at Asn114, Asn199, Asn414, Asn442
  • Modification sites at PhosphoSitePlus

  • See TLR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003255.2  
    ENSEMBL proteins: 
     ENSP00000260010  
    Reactome Protein details: O60603

    TLR2 Human Recombinant Protein Products:

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    OriGene Purified Protein for TLR2
    OriGene Protein Over-expression Lysate for TLR2
    OriGene MassSpec for TLR2
    OriGene Custom Protein Services for TLR2
    GenScript Custom Purified and Recombinant Proteins Services for TLR2
    Novus Biologicals TLR2 Proteins
    Novus Biologicals TLR2 Lysates
    Sino Biological Recombinant Protein for TLR2
    Sino Biological Cell Lysate for TLR2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR2

     
    Search eBioscience for Proteins for TLR2 

     
    antibodies-online proteins for TLR2 (16 products) 

     
    antibodies-online peptides for TLR2

    TLR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TLR2
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    Novus Biologicals TLR2 Antibodies
    Abcam antibodies for TLR2
    Cloud-Clone Corp. Antibodies for TLR2
    ThermoFisher Antibodies for TLR2
    antibodies-online antibodies for TLR2 (346 products) 

    TLR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for TLR2         (see all)
    GenScript Custom Assay Services for TLR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLR2
    Cloud-Clone Corp. CLIAs for TLR2
    Search eBioscience for ELISAs for TLR2 
    antibodies-online kits for TLR2 (42 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR2
    Toll-like receptor family

    Selected InterPro protein domains (see all 6):
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR017241 Toll-like_receptor
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry O60603

    ProtoNet protein and cluster: O60603

    3 Blocks protein domains:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603
    Domain: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12 (By
    similarity)
    Domain: The ATG16L1-binding motif mediates interaction with ATG16L1 (PubMed:23376921)
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 19 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TLR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR2_HUMAN, O60603
    Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial
    cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial
    lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and
    the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal
    macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM)
    and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6

         Genatlas biochemistry entry for TLR2:
    Drosophila transmembrane receptor Toll homolog 2,with two alternatively spliced isoforms,one expressed in lung,the
    other in heart,brain,muscle,mediator of liposaccharide (LPS) considered as a receptor,induced cellular
    signaling,involved in innate immunity through the recruitment of MYD88,against Gram positive bacteria

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001875lipopolysaccharide receptor activity TAS11518816
    GO:0004872receptor activity IDA11672593
    GO:0004888transmembrane signaling receptor activity IEA--
    GO:0005515protein binding IPI10854325
    GO:0008329signaling pattern recognition receptor activity IDA10384090
         
    Find genes that share ontologies with TLR2           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tlr2) (see all 21):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 

    Find genes that share phenotypes with TLR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TLR2: Tlr2tm1Kir Tlr2tm1Dgen Tlr2tm1Aki

       genOway: Develop your customized and physiologically relevant rodent model for TLR2

    miRNA
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    miRTarBase miRNAs that target TLR2:
    hsa-mir-19b-3p (MIRT006647), hsa-mir-105-5p (MIRT001127), hsa-mir-106b-5p (MIRT020445), hsa-mir-19a-3p (MIRT006646), hsa-mir-146a-5p (MIRT000449), hsa-mir-335-5p (MIRT019178)

    Block miRNA regulation of human, mouse, rat TLR2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TLR2:
    hsa-miR-579 hsa-miR-548v
    SwitchGear 3'UTR luciferase reporter plasmidTLR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TLR2
    Predesigned siRNA for gene silencing in human, mouse, rat TLR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TLR2

    Clone
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    OriGene clones in human, mouse for TLR2 (see all 7)
    OriGene ORF clones in mouse, rat for TLR2
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    GenScript: all cDNA clones in your preferred vector: TLR2 (NM_003264)
    Sino Biological Human cDNA Clone for TLR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR2
    Addgene plasmids for TLR2 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLR2_HUMAN, O60603: Membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    nucleus3
    vacuole2
    cytoskeleton1
    cytosol1
    endosome1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA19740627
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9435236
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface IDA12443841

    Find genes that share ontologies with TLR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLR2 About   (see all 30)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Chagas disease (American trypanosomiasis)0.32
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    Regulation of toll-like receptor signaling pathway0.93
    2NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    NOD-like Receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    Bacterial infections in CF airways0.78
    4Leishmaniasis
    Leishmaniasis0.35
    Inflammatory bowel disease (IBD)0.34
    Toxoplasmosis0.35
    5Defensins
    Defensins0.80
    Beta defensins0.80


    Find genes that share SuperPaths with TLR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TLR2 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLR2 (see all 11)
        MSP-RON Signaling
    NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    NTHi-Induced Signaling

    1 Cell Signaling Technology (CST) Pathway for TLR2
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR2
        Toll-like Receptor Pathway

    5 GeneGo (Thomson Reuters) Pathways for TLR2
        Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response Bacterial infections in normal airways
    Immune response TLR signaling pathways
    Bacterial infections in CF airways
    Mucin expression in CF via IL-6, IL-17 signaling pathways

    2 BioSystems Pathways for TLR2
        Toll-like receptor signaling pathway
    Regulation of toll-like receptor signaling pathway

    1 Sino Biological Pathway for TLR2
        NF-kB (NFkB) Pathway

    4 Reactome Pathways for TLR2
        Toll Like Receptor TLR6:TLR2 Cascade
    MyD88:Mal cascade initiated on plasma membrane
    Beta defensins
    Toll Like Receptor TLR1:TLR2 Cascade


    Selected Kegg Pathways  (Kegg details for TLR2) (see all 16):
        Phagosome
    PI3K-Akt signaling pathway
    Toll-like receptor signaling pathway
    Legionellosis
    Leishmaniasis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR2 (see all 11): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLR2 (O606031, 2, 3 ENSP000002600104) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8402469 I2D: score=3 STRING: ENSP00000274335
    ENSG00000183311P074373I2D: score=1 
    ENSG00000184494Q995193I2D: score=1 
    ENSG00000223957Q995193I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 65):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002238response to molecule of fungal origin IEA--
    GO:0002282microglial cell activation involved in immune response IEA--
    GO:0002687positive regulation of leukocyte migration IEA--

    Find genes that share ontologies with TLR2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for TLR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Pam2CSK4TLR2/6 agonist; induces TNF-alpha production[868247-72-7]
    ResiquimodToll-like receptor 7 (TLR7) agonist[144875-48-9]
    Pam3CSK4TLR1/2 agonist; induces cytokine production[112208-00-1]
    Poly(I:C)TLR3 agonist[42424-50-0]
    ImiquimodToll-like receptor 7 (TLR7) agonist[99011-02-6]

    2 DrugBank Compounds for TLR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-(Dimethylarsenic)Cysteine-- --target--17139284 17016423
    OspA lipoprotein-- --targetother/unknown14617145

    1 IUPHAR Ligand for TLR2 (TLR2)    About this table
    LigandTypeActionAffinityPubmed IDs
    peptidoglycan
    AgonistAgonist10384090 10364168

    Selected Novoseek inferred chemical compound relationships for TLR2 gene (see all 88)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoteichoic acid 90.7 191 10364168 (4), 12011760 (4), 18458151 (4), 12691617 (3) (see all 75)
    peptidoglycan 87.1 257 12874299 (6), 20118281 (5), 11292690 (4), 16239565 (4) (see all 99)
    loxoribine 75.5 4 17899542 (1), 17853407 (1), 15749901 (1), 15804290 (1)
    hbd2 74.1 10 18219831 (2), 16242370 (1), 15854033 (1), 17241164 (1) (see all 8)
    flagellin 73.8 30 16365459 (1), 16319082 (1), 16982839 (1), 19121068 (1) (see all 28)
    muramyl dipeptide 71.3 5 12537692 (1), 15617523 (1), 15839897 (1), 16299289 (1)
    poly(i-c) 65.8 7 16484229 (1), 16365459 (1), 16670332 (1), 16052591 (1) (see all 7)
    p3c-sk4 65.6 2 17662043 (1), 16412017 (1)
    endotoxin 61.5 28 12717397 (3), 16428799 (2), 10358136 (2), 10878331 (1) (see all 21)
    zymosan 60.1 16 12225373 (2), 19888805 (2), 12817025 (2), 19846883 (2) (see all 11)



    Find genes that share compounds with TLR2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLR2 gene: 
    NM_003264.3  

    Unigene Cluster for TLR2:

    Toll-like receptor 2
    Hs.519033  [show with all ESTs]
    Unigene Representative Sequence: AK125659
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000260010(uc021xtl.1)
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TLR2 (NM_003264)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLR2
      QuantiTect SYBR Green Assays in human, mouse, rat TLR2
      QuantiFast Probe-based Assays in human, mouse, rat TLR2

    Additional mRNA sequence: 

    AB445624.1 AF051152.1 AF424049.1 AF424050.1 AF424051.1 AF424052.1 AF424053.1 AF502291.1 
    AK125659.1 BC033756.1 DQ012265.1 DQ012266.1 DQ012267.1 DQ012268.1 DQ012269.1 DQ012270.1 
    DQ012271.1 U88878.1 

    5 DOTS entries:

    DT.212665  DT.100025207  DT.95146205  DT.121241774  DT.95266498 

    Selected AceView cDNA sequences (see all 67):

    CD367547 AW206320 AF424053 AA075065 BM676520 U88878 CB162652 CA448548 
    AI375928 BQ083606 AF424051 AI096846 AA075066 CD367292 AF424052 AI492029 
    BI769109 AF424049 AI017157 BM713905 CA748556 BU738748 BX095256 AW236149 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACGAGGCTC
    TLR2 Expression
    About this image


    TLR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    TLR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519033

    UniProtKB/Swiss-Prot: TLR2_HUMAN, O60603
    Tissue specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow,
    lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR2 (see all 11): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlr21 , 5 toll-like receptor 21, 5 75.64(n)1
    70.92(a)1
      3 (37.40 cM)5
    240881  NM_011905.31  NP_036035.31 
     838362725 
    chicken
    (Gallus gallus)
    Aves TLR2-21 toll-like receptor 2 60.08(n)
    53.71(a)
      769014  NM_001161650.1  NP_001155122.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Toll-like receptor
    (see all 4)
    50(a)
    47(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    5(130808868-130811195)
    5(130970195-130979396)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004857711 toll-like receptor 2 type-2-like 55.84(n)
    50.4(a)
      100485771  XM_002933491.2  XP_002933537.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tlr21 toll-like receptor 2 50.99(n)
    43.68(a)
      403125  NM_212812.1  NP_997977.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Toll-96
    Toll-9
    17(a)
    1 → many
    3L(20354943-20359824)


    ENSEMBL Gene Tree for TLR2 (if available)
    TreeFam Gene Tree for TLR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLR2 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR92  TLR52  TLR102  TLR42  
    TLR82  TLR62  TLR32  
    4 SIMAP similar genes for TLR2 using alignment to 8 protein entries:     TLR2_HUMAN (see all proteins):
    TLR3    TLR1    TLR6    TLR10

    Find genes that share paralogs with TLR2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TLR2
    PGOHUM00000246105


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    TLR2_HUMAN, O60603: Genetic variations in TLR2 are associated with susceptibility to leprosy [MIM:246300]. Leprosy is a
    chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower
    temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The
    Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy.
    Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the
    Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism
    for the poor cellular immune response associated with lepromatous leprosy


    Selected SNPs for TLR2 (see all 612)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378531771,2,,4
    C,Funtested1154411222(+) CTCCCA/CGCAGG 2 S R mis11Minor allele frequency- C:0.00NA 4528
    rs1219178641,2
    Cother1154411345(+) ATAAGC/TGGGAC 2 R W mis10--------
    rs722255661,2
    C--150339766(+) GGAGC-/TTTTTT 1 -- int10--------
    rs789525311,2
    C,F--154388750(+) CTAGAT/AGTGAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs2007317821,2
    --154388850(+) TTGGT-/GCCAGGA 1 -- us2k10--------
    rs76828141,2
    C,F--154388861(+) AGTTCG/AAGACC 1 -- us2k18Minor allele frequency- A:0.17NA WA CSA EA 133
    rs1474179301,2
    --154388935(+) GCACGC/TACCTG 1 -- us2k10--------
    rs1923481421,2
    --154388963(+) GAGGCC/TGAGGC 1 -- us2k10--------
    rs1396573411,2
    --154389031(+) CACTCC/TAGCCT 1 -- us2k10--------
    rs2015455321,2
    C--154389083(+) AAAAAA/GAAAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLR2 (154605441 - 154627243 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TLR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv482972CNV Gain15286789

    Human Gene Mutation Database (HGMD): TLR2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TLR2
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603028   
    OMIM disorders: 246300  114500  607948  
    Selected diseases for TLR2 (see all 34):    
    About MalaCards
    enthesitis-related arthritis    rheumatic fever    melioidosis    leprosy
    mycobacterium abscessus    tularemia    duodenal disease    lepromatous leprosy
    endotoxin hyporesponsiveness    filariasis    colorectal cancer    prosthetic joint infection
    burning mouth syndrome    septic arthritis    systemic lupus erythematosus, association with    pouchitis
    lyme disease    spondylarthropathy    granulomatosis with polyangiitis    aspergillosis

    15 diseases from the University of Copenhagen DISEASES database for TLR2:
    Tuberculosis     Periodontitis     Lyme disease     Pneumonia
    Arthritis     Inflammatory bowel disease     Tularemia     Atherosclerosis
    Meningitis     Asthma     Hypersensitivity reaction type I disease     Atopic dermatitis
    Leprosy     Mastitis     Otitis media

    Find genes that share disorders with TLR2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TLR2 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 70.6 97 18202345 (3), 19479087 (3), 19948979 (2), 19608024 (2) (see all 71)
    necrosis 67.2 106 15345653 (2), 16970685 (2), 12089142 (2), 15242847 (2) (see all 85)
    gram-positive bacterial infections 59.5 4 17456342 (1), 18424724 (1)
    bacterial infections 58.9 20 12853386 (3), 17437421 (2), 17889686 (2), 20402597 (1) (see all 15)
    tuberculosis 56.2 92 19552525 (5), 15322009 (3), 16365150 (3), 19686607 (3) (see all 54)
    mycobacterial infection 55.4 14 12646604 (1), 15270740 (1), 14687934 (1), 17056554 (1) (see all 8)
    sepsis 53.8 86 17456342 (7), 15086396 (7), 15489631 (5), 19371402 (4) (see all 27)
    chronic periodontitis 52.8 10 20233331 (2), 17176826 (2), 17956467 (2), 16274315 (1) (see all 7)
    shock septic 50.5 7 16878028 (1), 18302745 (1), 16670636 (1), 11035751 (1) (see all 7)
    leprosy lepromatous 45.2 12 15270740 (2), 12445799 (2), 12646604 (1), 12743710 (1) (see all 7)

    Genetic Association Database (GAD): TLR2
    Human Genome Epidemiology (HuGE) Navigator: TLR2 (236 documents)

    Export disorders for TLR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLR2 gene, integrated from 10 sources (see all 1885):
    (articles sorted by number of sources associating them with TLR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)1, 2, 3 Rock F.L.... Bazan J.F. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    2. A polymorphism in the toll-like receptor 2 is associated with IL-12 production from monocyte in lepromatous leprosy. (PubMed id 12445799)1, 4, 9 Kang T.J....Chae G.T. (Cytokine 2002)
    3. No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and BehAset's disease. (PubMed id 19693643)1, 4, 9 CoA9an F....GA1l A. (Clin. Rheumatol. 2009)
    4. Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: impact of the TLR-2 R753Q polymorphism. (PubMed id 18445187)1, 4, 9 Niebuhr M....Werfel T. (Allergy 2008)
    5. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. (PubMed id 9596645)1, 2, 9 Chaudhary P.M.... Nelson P.S. (Blood 1998)
    6. Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk. (PubMed id 19220214)1, 4, 9 Kormann M.S....Kabesch M. (Allergy 2009)
    7. Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. (PubMed id 11476982)1, 2, 9 Kang T.-J. and Chae G.-T. (FEMS Immunol. Med. Microbiol. 2001)
    8. Association between toll-like receptor polymorphisms and serum levels of tumor necrosis factor-alpha and its soluble receptors in obese children. (PubMed id 20357716)1, 4, 9 Jermendy A....Cseh K. (Med. Sci. Monit. 2010)
    9. Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (PubMed id 18809506)1, 4, 9 Moura S.B....MagalhALes Queiroz D.M. (Microbes Infect. 2008)
    10. Evidence for association between a Toll-like receptor 4 gene polymorphism and moderate/severe periodontitis in the Japanese population. (PubMed id 17956467)1, 4, 9 Fukusaki T....Yoshiura K. (J. Periodont. Res. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7097 HGNC: 11848 AceView: TLR2 Ensembl:ENSG00000137462 euGenes: HUgn7097
    ECgene: TLR2 Kegg: 7097 H-InvDB: TLR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLR2 gene:
    Search GeneIP for patents involving TLR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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