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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLR10 Gene

protein-coding   GIFtS: 56
GCID: GC04M038773

toll-like receptor 10

 Explore 29 diseases affiliated with
TLR10 via our new
 Human Malady Compendium 
Biological research products
for TLR10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Toll-Like Receptor 101 2
CD2901 2
CD290 Antigen3

External Ids:    HGNC: 156341   Entrez Gene: 817932   Ensembl: ENSG000001741237   OMIM: 6062705   UniProtKB: Q9BXR53   

Export aliases for TLR10 gene to outside databases

Previous GC identifers: GC04P039119 GC04M038938 GC04M038609 GC04M038671 GC04M038597 GC04M038450 GC04M038098


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR10:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share
structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective
immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid
tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which
encode different protein isoforms have been found for this gene. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5
Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to
NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

Gene Wiki entry for TLR10


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016297.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR10 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   GATA-1   Nkx3-1 v2   FOXO4   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR10 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLR10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

TLR10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M038773:  view genomic region     (about GC identifiers)

Start:
38,773,860 bp from pter      End:
38,784,611 bp from pter
Size:
10,752 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5 (See protein sequence)
Recommended Name: Toll-like receptor 10 precursor  
Size: 811 amino acids; 94564 Da
Subunit: Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
1 PDB 3D structure from and Proteopedia for TLR10:
2J67 (3D)    
Secondary accessions: A8K7L1 B3Y668 D1CS21 D1CS22 Q32MI7 Q32MI8 Q5FWG4 Q6UXL3

Explore the universe of human proteins at neXtProt for TLR10: NX_Q9BXR5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BXR5

  • TLR10 Protein expression data from MOPED and PaxDb:    About this image 
    TLR10 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001017388.1  NP_001182035.1  NP_001182036.1  NP_001182037.1  NP_112218.2  

    ENSEMBL proteins: 
     ENSP00000308925   ENSP00000421483   ENSP00000424923   ENSP00000427606   ENSP00000354459  
    Reactome Protein details: Q9BXR5
    Human Recombinant Protein Products for TLR10: 
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    Novus Biologicals TLR10 Protein
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    Uscn Proteins for TLR10

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS11267672
    GO:0016021integral to membrane IEA--

    TLR10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TLR10 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR017241 Toll-like_receptor
     IPR027182 TLR10

    Graphical View of Domain Structure for InterPro Entry Q9BXR5

    ProtoNet protein and cluster: Q9BXR5

    3 Blocks protein families:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 15 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 TIR domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR10_HUMAN, Q9BXR5
    Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to
    NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS11267672
         
    TLR10 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 10 (TLR10) Cascade0.86
    MyD88 cascade initiated on plasma membrane0.86
    Toll Like Receptor 5 (TLR5) Cascade0.86
    Toll-Like Receptors Cascades0.53
    2Immune System
    Immune System1.00
    Innate Immune System0.46
    3TRAF Pathway
    TRAF Pathway1.00
    Toll-Like Receptors Pathway0.41
    4NF-KappaB Family Pathway
    NF-KappaB Family Pathway1.00
    NF-KappaB (p50-p65) Pathway0.72
    5Th17 Differentiation
    Th17 Differentiation1.00
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5 R&D Systems Pathways for TLR10
        Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways
    Th17 Differentiation

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR10 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Tocris Bioscience Pathway for TLR10
        Toll-like Receptor Pathway

    5/7        Reactome Pathways for TLR10 (see all 7)
        Ligand binds to TLR10
    Toll-Like Receptors Cascades
    Toll Like Receptor 5 (TLR5) Cascade
    MyD88 cascade initiated on plasma membrane
    Toll Like Receptor 10 (TLR10) Cascade



    TLR10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for TLR10 (Q9BXR53 ENSP000003089254) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F8A1P236103, ENSP000003584564I2D: score=1 STRING: ENSP00000358456
    F8A2P236103I2D: score=1 
    F8A3P236103I2D: score=1 
    GLDCP233783, ENSP000003707374I2D: score=2 STRING: ENSP00000370737
    LUC7L3O952323, ENSP000002403044I2D: score=2 STRING: ENSP00000240304
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response NAS11267672
    GO:0045087innate immune response TAS--

    TLR10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TLR10
    Search CenterWatch for drugs/clinical trials and news about TLR10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLR10 gene (5 alternative transcripts): 
    NM_001017388.2  NM_001195106.1  NM_001195107.1  NM_001195108.1  NM_030956.3  

    Unigene Clusters for TLR10:

    Toll-like receptor 10
    Hs.120551  [show with all ESTs], Hs.730896  [show with all ESTs]
    Unigene Representative Sequences: NM_030956, AB445680
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308973(uc021xnk.1 uc003gtj.3 uc003gti.3 uc021xnl.1 uc003gtk.3)
    ENST00000506111 ENST00000508334 ENST00000502321 ENST00000507953 ENST00000361424


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    Additional cDNA sequence: 

    AB445680.1 DQ011502.1 DQ011503.1 DQ011504.1 DQ011505.1 DQ011506.1 DQ011507.1 DQ011508.1 
    DQ011509.1 DQ011510.1 DQ011511.1 DQ011512.1 DQ011513.1 DQ011514.1 DQ011515.1 DQ011516.1 

    9 DOTS entries:

    DT.108885  DT.99977576  DT.121222315  DT.91994979  DT.99932660  DT.100803693  DT.101957928  DT.203449 
    DT.92029856 

    24/47 AceView cDNA sequences (see all 47):

    AF296673 BM989026 BX108540 AY358300 BP383038 NM_030956 AA648836 AW500398 
    CF138723 AA287325 BU428566 AW401674 AA808299 BU198655 AW665250 BF224248 
    CF138833 AA811603 BU428569 CF137786 AA760895 BU431747 BU430893 BU430276 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TLR10 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:        -                                                         
    SP2:        -           -     -     -     -                           
    SP3:        -     -                                                   
    SP4:        -           -     -     -                                 
    SP5:                                                                  


    ECgene alternative splicing isoforms for TLR10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLR10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    TLR10 Expression
    About this image
    See TLR10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLR10

    SOURCE GeneReport for Unigene clusters: Hs.120551 Hs.730896

    UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5
    Tissue specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly
    expressed in promyelocytic HL-60 cells and in B-cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR10: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TLR10 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves Q5GDB1_CHICK6
    TLR156
    toll-like receptor 15
    47(a)
    20(a)
    1 ↔ many
    possible ortholog
    4(71561343-71566607)
    3(2945856-2948462)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    54(a)
    46(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343361.1(163037-164422)
    GL343361.1(130910-133312)
    zebrafish
    (Danio rerio)
    Actinopterygii tlr16
    toll-like receptor 1
    33(a)
    1 → many
    14(733852-738712)
    fruit fly
    (Drosophila melanogaster)
    Insecta Toll-96
    Tehao6
    (see all 5)
    Tehao
    (see all 5)
    14(a)
    14(a)
    (see all 5)
    1 ↔ many
    possible ortholog
    (see all 5)
    3L(20354943-20359824)
    2L(13435622-13439333)


    ENSEMBL Gene Tree for TLR10 (if available)
    TreeFam Gene Tree for TLR10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLR10 gene
    CD1802  ENSG000001733662  TLR72  TLR12  TLR92  TLR52  LRRC332  TLR42  
    TLR82  TLR62  LRRC322  TLR32  TLR22  
    7 SIMAP similar genes for TLR10 using alignment to 10 protein entries:     TLR10_HUMAN (see all proteins):
    TLR1    TLR6    SLIT3    TLR3    ISLR2    TLR2
    FLII

    TLR10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/366 NCBI SNPs in TLR10 are shown (see all 366    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285698351,2
    F--38773423(+) GCCCAA/GTGATA 5 -- ds50011Minor allele frequency- G:0.11WA 118
    rs1913951831,2
    --38773448(+) GCTGGG/TTGTGG 5 -- ds50010--------
    rs1848245531,2
    --38773464(+) CACACC/GTGTAA 5 -- ds50010--------
    rs1896501221,2
    C--38773500(+) AGGAGA/GATCAT 5 -- ds50010--------
    rs732366041,2
    C,F--38773523(+) GCTCAA/GTACTG 5 -- ds50014Minor allele frequency- G:0.08NA CSA WA 242
    rs1816950171,2
    --38773609(+) AAGAAA/GATGCA 5 -- ds50010--------
    rs1867631031,2
    --38773670(+) TCCCTA/GAATCA 5 -- ds50010--------
    rs789098241,2
    C--38773684(+) GTTTAA/GGCCAC 5 -- ds50012Minor allele frequency- G:0.07CSA WA 120
    rs1486898361,2
    C--38773693(+) CAAAA-/TTTTTT 5 -- ds50010--------
    rs45042661,2
    C,F,A--38773754(-) AATGAC/TAATTT 5 -- ds50013Minor allele frequency- T:0.34WA NA EA 358

    HapMap Linkage Disequilibrium report for TLR10 (38773860 - 38784611 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TLR10: --
    Human Gene Mutation Database (HGMD): TLR10

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TLR10 for disorders           About GeneDecksing

    OMIM gene information: 606270    OMIM disorders: --

    20/29 diseases for TLR10 (see all 29):    About MalaCards
    tonsillitis    non-hodgkin lymphoma    bronchiolitis obliterans    hodgkin's lymphoma
    melioidosis    bronchiolitis    multiple myeloma    keratitis
    rheumatoid arthritis    hepatitis b    rabies    asthma
    myeloma    alzheimer's disease    arthritis    periodontitis
    nasopharyngitis    meningioma    nephropathy    prostate cancer

    1 Novoseek disease relationship for TLR10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 10.1 2 16629799 (1), 16505608 (1)

    Genetic Association Database (GAD): TLR10
    Human Genome Epidemiology (HuGE) Navigator: TLR10 (38 documents)

    Export disorders for TLR10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLR10 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with TLR10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. (PubMed id 11267672)1, 2, 3 Chuang T.-H. and Ulevitch R.J. (2001)
    2. The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. (PubMed id 18332149)1, 2, 9 Nyman T....Nordlund P. (2008)
    3. The heterogeneous allelic repertoire of human toll-li ke receptor (TLR) genes. (PubMed id 19924287)1, 2 Georgel P....Bahram S. (2009)
    4. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2 Nakajima T....Kimura A. (2008)
    5. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. (PubMed id 15812078)1, 4 Sun J....Gronberg H. (2005)
    6. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. (PubMed id 15201134)1, 4 Lazarus R....Weiss S.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. (PubMed id 15728506)1, 9 Hasan U....Bates E.E. (2005)
    10. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. (PubMed id 20348427)1, 9 Guan Y....Tapping R.I. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81793 HGNC: 15634 AceView: TLR10 Ensembl:ENSG00000174123 euGenes: HUgn81793
    ECgene: TLR10 H-InvDB: TLR10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLR10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLR10 gene:
    Search GeneIP for patents involving TLR10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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