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TLR10 Gene

protein-coding   GIFtS: 61
GCID: GC04M038773

Toll-Like Receptor 10

  See TLR10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Toll-Like Receptor 101 2
CD2902
CD290 Antigen3

External Ids:    HGNC: 156341   Entrez Gene: 817932   Ensembl: ENSG000001741237   OMIM: 6062705   UniProtKB: Q9BXR53   
ORGUL members:         

Export aliases for TLR10 gene to outside databases

Previous GC identifers: GC04P039119 GC04M038938 GC04M038609 GC04M038671 GC04M038597 GC04M038450 GC04M038098


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLR10 Gene:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans
and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs)
that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of
effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed
in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript
variants which encode different protein isoforms have been found for this gene. (provided by RefSeq, Aug 2010)

GeneCards Summary for TLR10 Gene:
TLR10 (toll-like receptor 10) is a protein-coding gene. Diseases associated with TLR10 include melioidosis, and meniere's disease. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is ENSG00000173366.

UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5
Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to
NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

Gene Wiki entry for TLR10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLR10 gene promoter:
         Nkx3-1   Nkx3-1 v4   AML1a   POU3F2 (N-Oct-5a)   Nkx3-1 v1   POU3F2   GATA-1   Nkx3-1 v2   FOXO4   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLR10 promoter sequence
   Search Chromatin IP Primers for TLR10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLR10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

TLR10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR10 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M038773:  view genomic region     (about GC identifiers)

Start:
38,773,860 bp from pter      End:
38,784,611 bp from pter
Size:
10,752 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5 (See protein sequence)
Recommended Name: Toll-like receptor 10 precursor  
Size: 811 amino acids; 94564 Da
Subunit: Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential)
1 PDB 3D structure from and Proteopedia for TLR10:
2J67 (3D)    
Secondary accessions: A8K7L1 B3Y668 D1CS21 D1CS22 Q32MI7 Q32MI8 Q5FWG4 Q6UXL3

Explore the universe of human proteins at neXtProt for TLR10: NX_Q9BXR5

Explore proteomics data for TLR10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn33, Asn36, Asn140, Asn189, Asn236, Asn278, Asn330, Asn416, Asn427

  • See TLR10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001017388.1  NP_001182035.1  NP_001182036.1  NP_001182037.1  NP_112218.2  

    ENSEMBL proteins: 
     ENSP00000308925   ENSP00000421483   ENSP00000424923   ENSP00000427606   ENSP00000354459  
    Reactome Protein details: Q9BXR5

    TLR10 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TLR10
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    Novus Biologicals TLR10 Protein
    Novus Biologicals TLR10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLR10

     
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    TLR10 Antibody Products:

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    TLR10 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: TLR10
    Toll-like receptor family

    5 InterPro protein domains:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR017241 Toll-like_receptor
     IPR027182 TLR10

    Graphical View of Domain Structure for InterPro Entry Q9BXR5

    ProtoNet protein and cluster: Q9BXR5

    3 Blocks protein domains:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 15 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 TIR domain


    Find genes that share domains with TLR10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLR10_HUMAN, Q9BXR5
    Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to
    NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS11267672
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TLR10           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLR10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLR10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLR10

    miRNA
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    miRTarBase miRNAs that target TLR10:
    hsa-mir-92a-3p (MIRT049221)

    Block miRNA regulation of human, mouse, rat TLR10 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TLR10:
    hsa-miR-10b* hsa-miR-433 hsa-miR-889 hsa-miR-376c hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTLR10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLR10

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    GenScript: all cDNA clones in your preferred vector (see all 5): TLR10 (NM_001195108)
    Sino Biological Human cDNA Clone for TLR10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR10
    Addgene plasmids for TLR10 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TLR10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLR10_HUMAN, Q9BXR5: Membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    peroxisome2
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS11267672
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TLR10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLR10 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Inflammasome Activation Pathways0.51
    NOD-like Receptor Signaling Pathways0.58
    2NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    NF-KappaB Family Pathway0.72
    3Th17 Differentiation
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types0.47
    Th17 Differentiation0.47
    4TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41
    5Akt Signaling
    Tec Kinases Signaling0.55


    Find genes that share SuperPaths with TLR10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for TLR10 (see all 6)
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLR10 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Tocris Bioscience Pathway for TLR10
        Toll-like Receptor Pathway

    1 Sino Biological Pathway for TLR10
        NF-kB (NFkB) Pathway

    2 Reactome Pathways for TLR10
        Toll Like Receptor 10 (TLR10) Cascade
    MyD88 cascade initiated on plasma membrane


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR10: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLR10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TLR10 (Q9BXR53 ENSP000003089254) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    F8A1P236103, ENSP000003584564I2D: score=1 STRING: ENSP00000358456
    F8A2P236103I2D: score=1 
    F8A3P236103I2D: score=1 
    GLDCP233783, ENSP000003707374I2D: score=2 STRING: ENSP00000370737
    LUC7L3O952323, ENSP000002403044I2D: score=2 STRING: ENSP00000240304
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0006954inflammatory response IEA--
    GO:0006955immune response NAS11267672
    GO:0007165signal transduction ----

    Find genes that share ontologies with TLR10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLR10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLR10 gene (5 alternative transcripts): 
    NM_001017388.2  NM_001195106.1  NM_001195107.1  NM_001195108.1  NM_030956.3  

    Unigene Cluster for TLR10:

    Toll-like receptor 10
    Hs.120551  [show with all ESTs]
    Unigene Representative Sequence: NM_030956
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308973(uc021xnk.1 uc003gtj.3 uc003gti.3 uc021xnl.1 uc003gtk.3)
    ENST00000506111 ENST00000508334 ENST00000502321 ENST00000507953 ENST00000361424

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate TLR10:
    hsa-miR-10b* hsa-miR-433 hsa-miR-889 hsa-miR-376c hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTLR10 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): TLR10 (NM_001195108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLR10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLR10
    Addgene plasmids for TLR10 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TLR10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TLR10
      QuantiTect SYBR Green Assays in human, mouse, rat TLR10
      QuantiFast Probe-based Assays in human, mouse, rat TLR10

    Additional mRNA sequence: 

    AF296673.1 AK292026.1 AK313468.1 AY358300.1 BC089406.1 BC109111.2 BC109112.2 

    8 DOTS entries:

    DT.108885  DT.99977576  DT.91994979  DT.99932660  DT.121222315  DT.101957928  DT.203449  DT.92029856 

    Selected AceView cDNA sequences (see all 47):

    BP383038 AY358300 AF296673 BM989026 BX108540 NM_030956 AA808299 CF138833 
    AW401674 AW500398 BU198655 BU428566 BF224248 CF138723 AA287325 AA811603 
    AA648836 AW665250 AV714601 AA740990 CF137786 BU430010 AW500479 AW503860 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TLR10 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:        -                                                         
    SP2:        -           -     -     -     -                           
    SP3:        -     -                                                   
    SP4:        -           -     -     -                                 
    SP5:                                                                  


    ECgene alternative splicing isoforms for TLR10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLR10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TLR10 Expression
    About this image


    TLR10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    TLR10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLR10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.120551

    UniProtKB/Swiss-Prot: TLR10_HUMAN, Q9BXR5
    Tissue specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly
    expressed in promyelocytic HL-60 cells and in B-cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLR10: 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TLR10
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TLR10
    QuantiTect SYBR Green Assays in human, mouse, rat TLR10
    QuantiFast Probe-based Assays in human, mouse, rat TLR10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLR10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLR10 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    rat
    (Rattus norvegicus)
    Mammalia Tlr101 toll-like receptor 10 77.75(n)
    71.2(a)
      305355  NM_001146035.1  NP_001139507.1 
    chicken
    (Gallus gallus)
    Aves TLR1LA6
    TLR1LB6
    Gallus gallus toll-like receptor 1-like A (TLR1LA)...
    Gallus gallus toll-like receptor 1-like B (TLR1LB)...
    48(a)
    46(a)
    many ↔ many
    many ↔ many
    4(69131053-69133509)
    4(69117413-69122553)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Toll-like receptor
    46(a)
    45(a)
    many ↔ many
    many ↔ many
    GL343361.1(130910-133312)
    GL343361.1(162095-164458)
    zebrafish
    (Danio rerio)
    Actinopterygii tlr16
    toll-like receptor 1
    33(a)
    1 → many
    14(733852-738712) ENSDARG00000043032
    fruit fly
    (Drosophila melanogaster)
    Insecta Toll-96
    Toll-9
    18(a)
    1 → many
    3L(20354943-20359824)


    ENSEMBL Gene Tree for TLR10 (if available)
    TreeFam Gene Tree for TLR10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLR10 gene
    ENSG000001733662  CD1802  TLR72  TLR12  TLR92  TLR52  TLR42  TLR82  
    TLR62  TLR32  TLR22  
    6 SIMAP similar genes for TLR10 using alignment to 10 protein entries:     TLR10_HUMAN (see all proteins):
    TLR1    TLR6    SLIT3    ISLR2    TLR2    FLII

    Find genes that share paralogs with TLR10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLR10 (see all 455)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs285698351,2
    F--38773423(+) GCCCAA/GTGATA 5 -- ds50011Minor allele frequency- G:0.11WA 118
    rs1913951831,2
    --38773448(+) GCTGGG/TTGTGG 5 -- ds50010--------
    rs1848245531,2
    --38773464(+) CACACC/GTGTAA 5 -- ds50010--------
    rs1896501221,2
    C--38773500(+) AGGAGA/GATCAT 5 -- ds50010--------
    rs732366041,2
    C,F--38773523(+) GCTCAA/GTACTG 5 -- ds50014Minor allele frequency- G:0.08NA CSA WA 242
    rs1816950171,2
    --38773609(+) AAGAAA/GATGCA 5 -- ds50010--------
    rs1867631031,2
    --38773670(+) TCCCTA/GAATCA 5 -- ds50010--------
    rs789098241,2
    C,F--38773684(+) GTTTAA/GGCCAC 5 -- ds50012Minor allele frequency- G:0.07CSA WA 120
    rs1486898361,2
    C--38773693(+) TTTTT-/TCTAAC 5 -- ds50010--------
    rs45042661,2
    C,F,A--38773754(-) AATGAC/TAATTT 5 -- ds50013Minor allele frequency- T:0.34WA NA EA 358

    HapMap Linkage Disequilibrium report for TLR10 (38773860 - 38784611 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TLR10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv275476CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): TLR10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLR10
    DNA2.0 Custom Variant and Variant Library Synthesis for TLR10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606270    OMIM disorders: --

    2 diseases for TLR10:    
    About MalaCards
    melioidosis    meniere's disease


    Find genes that share disorders with TLR10           About GenesLikeMe

    1 Novoseek inferred disease relationship for TLR10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 10.1 2 16629799 (1), 16505608 (1)

    Genetic Association Database (GAD): TLR10
    Human Genome Epidemiology (HuGE) Navigator: TLR10 (38 documents)

    Export disorders for TLR10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TLR10 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with TLR10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. (PubMed id 11267672)1, 2, 3 Chuang T.-H. and Ulevitch R.J. (Biochim. Biophys. Acta 2001)
    2. The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. (PubMed id 18332149)1, 2, 9 Nyman T....Nordlund P. (J. Biol. Chem. 2008)
    3. Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases. (PubMed id 18776592)1, 4, 9 Mailaparambil B....Heinzmann A. (Dis. Markers 2008)
    4. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. (PubMed id 18752252)1, 4, 9 Stevens V.L....Rodriguez C. (Int. J. Cancer 2008)
    5. Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk. (PubMed id 16702361)1, 4, 9 Zhou X.X....Zeng Y.X. (amp 2006)
    6. Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients. (PubMed id 20595247)1, 4 Enevold C....Bendtzen K. (Mult. Scler. 2010)
    7. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    8. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    9. Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. (PubMed id 20227302)1, 4 Kastelijn E.A....van den Bosch J.M. (J. Heart Lung Transplant. 2010)
    10. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 81793 HGNC: 15634 AceView: TLR10 Ensembl:ENSG00000174123 euGenes: HUgn81793
    ECgene: TLR10 H-InvDB: TLR10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TLR10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TLR10 gene:
    Search GeneIP for patents involving TLR10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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