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Aliases for TLR10 Gene

Aliases for TLR10 Gene

  • Toll-Like Receptor 10 2 3
  • CD290 Antigen 4
  • CD290 3

External Ids for TLR10 Gene

Previous GeneCards Identifiers for TLR10 Gene

  • GC04P039119
  • GC04M038938
  • GC04M038609
  • GC04M038671
  • GC04M038597
  • GC04M038450
  • GC04M038098

Summaries for TLR10 Gene

Entrez Gene Summary for TLR10 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for TLR10 Gene

TLR10 (Toll-Like Receptor 10) is a Protein Coding gene. Diseases associated with TLR10 include melioidosis and meniere's disease. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include transmembrane signaling receptor activity. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR10 Gene

  • Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Gene Wiki entry for TLR10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR10 Gene

Genomics for TLR10 Gene

Regulatory Elements for TLR10 Gene

Genomic Location for TLR10 Gene

Start:
38,772,239 bp from pter
End:
38,782,990 bp from pter
Size:
10,752 bases
Orientation:
Minus strand

Genomic View for TLR10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR10 Gene

Proteins for TLR10 Gene

  • Protein details for TLR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXR5-TLR10_HUMAN
    Recommended name:
    Toll-like receptor 10
    Protein Accession:
    Q9BXR5
    Secondary Accessions:
    • A8K7L1
    • B3Y668
    • D1CS21
    • D1CS22
    • Q32MI7
    • Q32MI8
    • Q5FWG4
    • Q6UXL3

    Protein attributes for TLR10 Gene

    Size:
    811 amino acids
    Molecular mass:
    94564 Da
    Quaternary structure:
    • Binds MYD88 via their respective TIR domains (By similarity). Homodimer (Potential).

    Three dimensional structures from OCA and Proteopedia for TLR10 Gene

neXtProt entry for TLR10 Gene

Proteomics data for TLR10 Gene at MOPED

Post-translational modifications for TLR10 Gene

  • Glycosylation at Asn33, Asn36, Asn140, Asn189, Asn236, Asn278, Asn330, Asn416, and Asn427
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TLR10 Gene

Domains for TLR10 Gene

Gene Families for TLR10 Gene

HGNC:
  • CD :CD molecules
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q9BXR5

UniProtKB/Swiss-Prot:

TLR10_HUMAN :
  • Q9BXR5
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR10: view

Function for TLR10 Gene

Molecular function for TLR10 Gene

UniProtKB/Swiss-Prot Function: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Gene Ontology (GO) - Molecular Function for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity TAS 11267672
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TLR10: view

Animal Model Products

CRISPR Products

miRNA for TLR10 Gene

miRTarBase miRNAs that target TLR10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TLR10 Gene

Localization for TLR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR10 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR10 Gene COMPARTMENTS Subcellular localization image for TLR10 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 11267672
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLR10: view

Pathways for TLR10 Gene

genes like me logo Genes that share pathways with TLR10: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Toll-Like Receptor Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for TLR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response NAS 11267672
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with TLR10: view

Transcripts for TLR10 Gene

Unigene Clusters for TLR10 Gene

Toll-like receptor 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR10

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TLR10
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLR10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - - - - -
SP3: - -
SP4: - - - -
SP5:
SP6:
SP7: - - - - -

Relevant External Links for TLR10 Gene

GeneLoc Exon Structure for
TLR10
ECgene alternative splicing isoforms for
TLR10

Expression for TLR10 Gene

mRNA expression in normal human tissues for TLR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR10 Gene

This gene is overexpressed in Spleen (8.0) and Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TLR10 Gene

SOURCE GeneReport for Unigene cluster for TLR10 Gene Hs.120551

mRNA Expression by UniProt/SwissProt for TLR10 Gene

Q9BXR5-TLR10_HUMAN
Tissue specificity: Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines
genes like me logo Genes that share expressions with TLR10: view

In Situ Assay Products

Orthologs for TLR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR10 35
  • 99.22 (n)
  • 99.26 (a)
TLR10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLR10 35
  • 85.94 (n)
  • 80.64 (a)
TLR10 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR10 35
  • 87.36 (n)
  • 82.03 (a)
TLR10 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 13 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TLR10 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr10 35
  • 77.75 (n)
  • 71.2 (a)
chicken
(Gallus gallus)
Aves TLR1LA 36
  • 48 (a)
ManyToMany
TLR1LB 36
  • 46 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii tlr1 36
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 36
  • 18 (a)
OneToMany
Species with no ortholog for TLR10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR10 Gene

ENSEMBL:
Gene Tree for TLR10 (if available)
TreeFam:
Gene Tree for TLR10 (if available)

Paralogs for TLR10 Gene

Paralogs for TLR10 Gene

genes like me logo Genes that share paralogs with TLR10: view

Variants for TLR10 Gene

Sequence variations from dbSNP and Humsavar for TLR10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4129008 -, -, - 38,773,195(-) GTCTC(A/C/G/T)AGGTT missense, reference
rs4129009 -, -, - 38,773,268(-) CTGCT(A/C/G/T)TTAAT reference, missense
rs4130727 -- 38,779,492(+) TAATT(A/G)TCAGA intron-variant
rs4274855 -- 38,775,850(-) ACAAC(A/G)GAGAC intron-variant, utr-variant-5-prime
rs4321646 -- 38,782,343(-) CTACA(C/T)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLR10 Gene

Variant ID Type Subtype PubMed ID
esv275476 CNV Gain+Loss 21479260

Relevant External Links for TLR10 Gene

HapMap Linkage Disequilibrium report
TLR10
Human Gene Mutation Database (HGMD)
TLR10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLR10 Gene

Disorders for TLR10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TLR10 Gene including...

Search for TLR10 Gene in MalaCards »

(1) Novoseek inferred disease relationships for TLR10 Gene

Disease -log(P) Hits PubMed IDs
asthma 10.1 2

Relevant External Links for TLR10

Genetic Association Database (GAD)
TLR10
Human Genome Epidemiology (HuGE) Navigator
TLR10
genes like me logo Genes that share disorders with TLR10: view

No data available for UniProtKB/Swiss-Prot for TLR10 Gene

Publications for TLR10 Gene

  1. Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk. (PMID: 16702361) Zhou X.X. … Zeng Y.X. (Cancer Epidemiol. Biomarkers Prev. 2006) 3 23 48
  2. The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer. (PMID: 18332149) Nyman T. … Nordlund P. (J. Biol. Chem. 2008) 3 4 23
  3. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. (PMID: 18752252) Stevens V.L. … Rodriguez C. (Int. J. Cancer 2008) 3 23 48
  4. Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases. (PMID: 18776592) Mailaparambil B. … Heinzmann A. (Dis. Markers 2008) 3 23 48
  5. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. (PMID: 11267672) Chuang T.-H. … Ulevitch R.J. (Biochim. Biophys. Acta 2001) 2 3 4

Products for TLR10 Gene

  • Addgene plasmids for TLR10

Sources for TLR10 Gene

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