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Aliases for TLR1 Gene

Aliases for TLR1 Gene

  • Toll-Like Receptor 1 2 3
  • Toll/Interleukin-1 Receptor-Like Protein 3 4
  • TIL 3 4
  • CD281 Antigen 4
  • TIL. LPRS5 3
  • KIAA0012 4
  • Rsc786 3
  • CD281 3

External Ids for TLR1 Gene

Previous GeneCards Identifiers for TLR1 Gene

  • GC04P039090
  • GC04M038961
  • GC04M038632
  • GC04M038695
  • GC04M038620
  • GC04M038474
  • GC04M038122

Summaries for TLR1 Gene

Entrez Gene Summary for TLR1 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR1 Gene

TLR1 (Toll-Like Receptor 1) is a Protein Coding gene. Diseases associated with TLR1 include leprosy 5 and neurosyphilis. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR1 Gene

  • Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Tocris Summary for TLR1 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

Gene Wiki entry for TLR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR1 Gene

Genomics for TLR1 Gene

Regulatory Elements for TLR1 Gene

Genomic Location for TLR1 Gene

Chromosome:
4
Start:
38,787,555 bp from pter
End:
38,856,817 bp from pter
Size:
69,263 bases
Orientation:
Minus strand

Genomic View for TLR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR1 Gene

Proteins for TLR1 Gene

  • Protein details for TLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15399-TLR1_HUMAN
    Recommended name:
    Toll-like receptor 1
    Protein Accession:
    Q15399
    Secondary Accessions:
    • D1CS39
    • D1CS41
    • O15452
    • Q32MK3
    • Q32MK4
    • Q9UG90

    Protein attributes for TLR1 Gene

    Size:
    786 amino acids
    Molecular mass:
    90291 Da
    Quaternary structure:
    • Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.
    SequenceCaution:
    • Sequence=BAA02801.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TLR1 Gene

neXtProt entry for TLR1 Gene

Proteomics data for TLR1 Gene at MOPED

Post-translational modifications for TLR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLR1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLR1 (TLR1)

No data available for DME Specific Peptides for TLR1 Gene

Domains & Families for TLR1 Gene

Gene Families for TLR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15399

UniProtKB/Swiss-Prot:

TLR1_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the Toll-like receptor family.
  • Contains 19 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 19 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR1: view

Function for TLR1 Gene

Molecular function for TLR1 Gene

GENATLAS Biochemistry:
Drosophila transmembrane receptor Toll homolog 1,ubiquitously expressed,with at least two alternatively spliced isoforms,tissue specific,maybe involved in morphogenesis and immune defense
UniProtKB/Swiss-Prot Function:
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Gene Ontology (GO) - Molecular Function for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10426995
GO:0004888 transmembrane signaling receptor activity NAS 11081518
GO:0005515 protein binding --
GO:0046982 protein heterodimerization activity IDA 17889651
genes like me logo Genes that share ontologies with TLR1: view
genes like me logo Genes that share phenotypes with TLR1: view

Animal Models for TLR1 Gene

MGI Knock Outs for TLR1:

Animal Model Products

miRNA for TLR1 Gene

miRTarBase miRNAs that target TLR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TLR1 Gene

Localization for TLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR1 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR1 Gene COMPARTMENTS Subcellular localization image for TLR1 gene
Compartment Confidence
plasma membrane 5
cytosol 2
endosome 2
extracellular 2
lysosome 2
nucleus 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9435236
GO:0016020 membrane NAS 11081518
GO:0016021 integral component of membrane --
GO:0030670 phagocytic vesicle membrane IEA --
genes like me logo Genes that share ontologies with TLR1: view

Pathways & Interactions for TLR1 Gene

genes like me logo Genes that share pathways with TLR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antigen Presenting Cells in human,mouse,rat
    • Antibacterial Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006952 defense response --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 10426995
genes like me logo Genes that share ontologies with TLR1: view

No data available for SIGNOR curated interactions for TLR1 Gene

Drugs & Compounds for TLR1 Gene

(4) Drugs for TLR1 Gene - From: NovoSeek and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imiquimod Approved, Investigational Pharma Agonist TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist 126
Resiquimod Pharma Toll-like receptor 7 (TLR7) agonist 0
FLAGELLIN Pharma Agonist 0
peptidoglycan Pharma Agonist 0

(5) Additional Compounds for TLR1 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Pam3CSK4
112208-00-1
Pam3CSK4 Biotin
Poly(I:C)
24939-03-5
LIPID
lipoteichoic acid
genes like me logo Genes that share compounds with TLR1: view

Transcripts for TLR1 Gene

Unigene Clusters for TLR1 Gene

Toll-like receptor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - - - - -

Relevant External Links for TLR1 Gene

GeneLoc Exon Structure for
TLR1
ECgene alternative splicing isoforms for
TLR1

Expression for TLR1 Gene

mRNA expression in normal human tissues for TLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR1 Gene

This gene is overexpressed in Whole Blood (x26.6).

Protein differential expression in normal tissues from HIPED for TLR1 Gene

This gene is overexpressed in Monocytes (58.7) and CD8 Tcells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR1 Gene



SOURCE GeneReport for Unigene cluster for TLR1 Gene Hs.654532

mRNA Expression by UniProt/SwissProt for TLR1 Gene

Q15399-TLR1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine
genes like me logo Genes that share expression patterns with TLR1: view

Protein tissue co-expression partners for TLR1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for TLR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR1 36
  • 98 (a)
OneToOne
TLR1 35
  • 99.24 (n)
  • 98.35 (a)
mouse
(Mus musculus)
Mammalia Tlr1 36
  • 73 (a)
OneToOne
Tlr1 16
Tlr1 35
  • 77.1 (n)
  • 74.07 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TLR1 36
  • 79 (a)
OneToOne
TLR1 35
  • 85.54 (n)
  • 79.85 (a)
rat
(Rattus norvegicus)
Mammalia Tlr1 35
  • 78.42 (n)
  • 73.44 (a)
chicken
(Gallus gallus)
Aves TLR1LB 36
  • 48 (a)
ManyToMany
TLR1LA 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tlr1 35
  • 54.94 (n)
  • 44.93 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr1 36
  • 34 (a)
OneToMany
tlr1 35
  • 48.05 (n)
  • 37.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 36
  • 18 (a)
OneToMany
Species with no ortholog for TLR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR1 Gene

ENSEMBL:
Gene Tree for TLR1 (if available)
TreeFam:
Gene Tree for TLR1 (if available)

Paralogs for TLR1 Gene

Paralogs for TLR1 Gene

Pseudogenes.org Pseudogenes for TLR1 Gene

genes like me logo Genes that share paralogs with TLR1: view

Variants for TLR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR1 Gene

Q15399-TLR1_HUMAN
Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIM:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy

Sequence variations from dbSNP and Humsavar for TLR1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_018474 -
VAR_031916 -
VAR_031917 -
VAR_031918 -
VAR_031919 -

Structural Variations from Database of Genomic Variants (DGV) for TLR1 Gene

Variant ID Type Subtype PubMed ID
dgv5526n71 CNV Loss 21882294

Variation tolerance for TLR1 Gene

Residual Variation Intolerance Score: 96.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLR1 Gene

HapMap Linkage Disequilibrium report
TLR1
Human Gene Mutation Database (HGMD)
TLR1

Disorders for TLR1 Gene

MalaCards: The human disease database

(20) MalaCards diseases for TLR1 Gene - From: OMIM, ClinVar, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
leprosy 5
  • leprosy, protection against
neurosyphilis
leprosy
  • leprosy, susceptibility to
melioidosis
  • nightcliff gardener's disease
mycobacterium abscessus
  • m. abscessus
- elite association
Search TLR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLR1

Genetic Association Database (GAD)
TLR1
Human Genome Epidemiology (HuGE) Navigator
TLR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLR1
genes like me logo Genes that share disorders with TLR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR1 Gene

Publications for TLR1 Gene

  1. Toll-like receptor expression on peripheral blood mononuclear cells in asthmatics; implications for asthma management. (PMID: 20072849) Chun E. … Park H.W. (J. Clin. Immunol. 2010) 23 67
  2. Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling. (PMID: 20348427) Guan Y. … Tapping R.I. (J. Immunol. 2010) 23 67
  3. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (PMID: 19771452) Velez D.R. … Scott W.K. (Hum. Genet. 2010) 23 67
  4. Identification, characterization and genetic mapping of TLR1 loci in rainbow trout (Oncorhynchus mykiss). (PMID: 20153434) Palti Y. … Wiens G.D. (Fish Shellfish Immunol. 2010) 23 67
  5. Expression and function of toll like receptors in chronic lymphocytic leukaemia cells. (PMID: 19036098) Muzio M. … Caligaris-Cappio F. (Br. J. Haematol. 2009) 23 67

Products for TLR1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TLR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TLR1
    • Block miRNA regulation of TLR1 using miScript Target Protectors

    Sources for TLR1 Gene

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