Aliases for TLR1 Gene
Aliases for TLR1 Gene
External Ids for TLR1 Gene
- HGNC: 11847
- Entrez Gene: 7096
- Ensembl: ENSG00000174125
- OMIM: 601194
- UniProtKB: Q15399
Previous GeneCards Identifiers for TLR1 Gene
- GC04P039090
- GC04M038961
- GC04M038632
- GC04M038695
- GC04M038620
- GC04M038474
- GC04M038122
Summaries for TLR1 Gene
-
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TLR1 Gene
TLR1 (Toll Like Receptor 1) is a Protein Coding gene. Diseases associated with TLR1 include Leprosy 5 and Lyme Disease. Among its related pathways are TRAF Pathway and Bacterial infections in CF airways. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR6.
UniProtKB/Swiss-Prot for TLR1 Gene
-
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
-
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR1 Gene
Genomics for TLR1 Gene
Regulatory Elements for TLR1 Gene
Enhancers for TLR1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TLR1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TLR1 gene promoter:
Regulatory Element Products
Genomic Location for TLR1 Gene
- Chromosome:
- 4
- Start:
- 38,787,555 bp from pter
- End:
- 38,856,817 bp from pter
- Size:
- 69,263 bases
- Orientation:
- Minus strand
Genomic View for TLR1 Gene
Genes around TLR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p14 by Ensembl
- 4p14 by Entrez Gene
- 4p14 by HGNC
TLR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLR1 Gene
Proteins for TLR1 Gene
-
Protein details for TLR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15399-TLR1_HUMAN
- Recommended name:
- Toll-like receptor 1
- Protein Accession:
- Q15399
- D1CS39
- D1CS41
- O15452
- Q32MK3
- Q32MK4
- Q9UG90
Protein attributes for TLR1 Gene
- Size:
- 786 amino acids
- Molecular mass:
- 90291 Da
- Quaternary structure:
-
- Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211, PubMed:17889651). The activation cluster TLR2:TLR1:CD14 forms in response to triacylated lipopeptides (PubMed:16880211). Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity).
- SequenceCaution:
-
- Sequence=BAA02801.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for TLR1 Gene
Post-translational modifications for TLR1 Gene
Other Protein References for TLR1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for TLR1
- R&D Systems Antibodies for TLR1 (TLR1)
- Cell Signaling Technology (CST) Antibodies for TLR1 (TLR1)
- Novus Biologicals Antibodies for TLR1
-
Cloud-Clone Corp. Antibodies for TLR1
- Invitrogen Antibodies for TLR1
- antibodies-online Antibodies for TLR1: See all 201
- GeneTex TLR1 antibody for TLR1
-
Custom Antibody ServicesProSci Antibodies for TLR1
-
Santa Cruz Biotechnology (SCBT) Antibodies for TLR1
Protein Products
- R&D Systems Proteins and Enzymes for TLR1
- Enzo Life Sciences proteins for TLR1
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TLR1
- Origene Custom Protein Services for TLR1
-
Cloud-Clone Corp. Proteins for TLR1
- antibodies-online Proteins for TLR1: See all 13
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TLR1
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for TLR1
-
Cloud-Clone Corp Assay Kits for TLR1
- antibodies-online Kits for TLR1: See all 16
No data available for DME Specific Peptides for TLR1 Gene
Domains & Families for TLR1 Gene
Gene Families for TLR1 Gene
- HGNC:
- IUPHAR :
Protein Domains for TLR1 Gene
Suggested Antigen Peptide Sequences for TLR1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15399- Family:
-
- Belongs to the Toll-like receptor family.
Function for TLR1 Gene
Molecular function for TLR1 Gene
- GENATLAS Biochemistry:
- Drosophila transmembrane receptor Toll homolog 1,ubiquitously expressed,with at least two alternatively spliced isoforms,tissue specific,maybe involved in morphogenesis and immune defense
- UniProtKB/Swiss-Prot Function:
- Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004872 | receptor activity | TAS | 10426995 |
| GO:0004888 | transmembrane signaling receptor activity | NAS | 11081518 |
| GO:0005515 | protein binding | IPI | 16880211 |
| GO:0035663 | Toll-like receptor 2 binding | IPI | 16880211 |
| GO:0046982 | protein heterodimerization activity | IDA | 17889651 |
Phenotypes for TLR1 Gene
- MGI mutant phenotypes for TLR1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for TLR1:
-
- Increased viability
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLR1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TLR1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR1 gene
- Search ViGene Biosciences for TLR1
CRISPR Products
-
OriGene CRISPR knockouts for TLR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR1
- GenScript: Design CRISPR guide RNA sequences for TLR1
miRNA for TLR1 Gene
- miRTarBase miRNAs that target TLR1
miRNA Products
- Search ViGene Biosciences for TLR1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TLR1
- Browse OriGene Inhibitory RNA Products For TLR1
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR1 gene
Clone Products
- Sino Biological Human cDNA Clone for TLR1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TLR1
- VectorBuilder custom plasmid, inducible vectors for TLR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for TLR1
Cell Line Products
-
Horizon Cell Lines for TLR1
-
ViGene Biosciences adenoviral particle packaged cDNA for TLR1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TLR1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLR1 Gene
Localization for TLR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLR1 Gene
- Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000269 PubMed:16880211}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| golgi apparatus | 5 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005794 | Golgi apparatus | IEA,IDA | 16880211 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 9435236 |
| GO:0016020 | membrane | NAS | 11081518 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TLR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | Toll-like Receptor Signaling Pathway | ||
| 4 | Toll-Like receptor Signaling Pathways | ||
| 5 | Defensins |
.83
.83
|
|
Pathways by source for TLR1 Gene
1 GeneTex pathway for TLR1 Gene
1 Cell Signaling Technology pathway for TLR1 Gene
5 BioSystems pathways for TLR1 Gene
22 Reactome pathways for TLR1 Gene
2 KEGG pathways for TLR1 Gene
3 GeneGo (Thomson Reuters) pathways for TLR1 Gene
7 R&D Systems pathways for TLR1 Gene
1 Tocris pathway for TLR1 Gene
8 Qiagen pathways for TLR1 Gene
Interacting Proteins for TLR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001775 | cell activation | IDA | 15294986 |
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | -- |
| GO:0006952 | defense response | IEA | -- |
No data available for SIGNOR curated interactions for TLR1 Gene
Drugs & Compounds for TLR1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(5) Tocris Compounds for TLR1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CU CPT 22 | Selective TLR1/2 inhibitor | 1416324-85-0 |
| CU CPT 4a | Selective TLR3 inhibitor | 1279713-77-7 |
| Pam3CSK4 | TLR1/2 agonist; induces cytokine production | 112208-00-1 |
| Poly(I:C) | TLR3 agonist | 24939-03-5 |
| Resiquimod | Toll-like receptor 7 (TLR7) agonist | 144875-48-9 |
(9) ApexBio Compounds for TLR1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CU CPT 22 | 1416324-85-0 | |
| CU CPT 4a | 1279713-77-7 | |
| Pam2CSK4 | 868247-72-7 | |
| Pam2CSK4 Biotin | ||
| Pam3CSK4 | 112208-00-1 | |
| Pam3CSK4 Biotin | ||
| Poly(I:C) | 24939-03-5 | |
| RWJ 21757 | 121288-39-9 | |
| Toll-like receptor modulator | TLR antagonist | 926927-42-6 |
Transcripts for TLR1 Gene
mRNA/cDNA for TLR1 Gene
- (8) REFSEQ mRNAs :
- (20) Additional mRNA sequences :
- (37) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TLR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLR1
- GenScript: Design CRISPR guide RNA sequences for TLR1
miRNA Products
- Search ViGene Biosciences for TLR1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TLR1
- Browse OriGene Inhibitory RNA Products For TLR1
-
ViGene Biosciences ready-to-package AAV shRNAs for TLR1 gene
Clone Products
- Sino Biological Human cDNA Clone for TLR1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TLR1
- VectorBuilder custom plasmid, inducible vectors for TLR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for TLR1
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - |
Expression for TLR1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Monocytes Peripheral Blood
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Conventional Dendritic Cells II Spleen
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
- Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TLR1 Gene
This gene is overexpressed in Whole Blood (x26.6).
This gene is overexpressed in Monocytes (58.7) and CD8 Tcells (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TLR1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TLR1 Gene:
TLR1SOURCE GeneReport for Unigene cluster for TLR1 Gene:
Hs.654532mRNA Expression by UniProt/SwissProt for TLR1 Gene:
Q15399-TLR1_HUMAN
Tissue specificity:
Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.
Evidence on tissue expression from TISSUES for TLR1 Gene
- Blood(4.6)
- Bone marrow(4.4)
- Liver(4.3)
- Nervous system(4.3)
- Spleen(2.9)
- Lymph node(2.7)
- Intestine(2.4)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for TLR1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR1 Gene
Orthologs for TLR1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TLR1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TLR1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tlr1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tlr1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | TLR1LA 35 |
|
ManyToMany | |
| TLR1LB 35 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tlr1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tlr1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Toll-9 35 |
|
OneToMany |
- Species where no ortholog for TLR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TLR1 Gene
Paralogs for TLR1 Gene
(3) SIMAP similar genes for TLR1 Gene using alignment to 14 proteins:
Pseudogenes.org Pseudogenes for TLR1 Gene
Variants for TLR1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for TLR1 Gene
- TLR1_HUMAN-Q15399
- Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIM:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy.
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs55812771 | Benign | 38,797,285(+) | ACCTC(A/T)TCTTC | nc-transcript-variant, reference, missense | |
| rs773733396 | Benign | 38,797,418(+) | GAGTT(A/C/T)TTGCA | nc-transcript-variant, reference, missense, stop-gained | |
| rs786201033 | Benign | 38,798,034(-) | CTCCA(A/G)CTGGT | nc-transcript-variant, reference, synonymous-codon | |
| rs786201035 | Benign | 38,797,328(-) | ATTCA(A/G)TTTCC | nc-transcript-variant, reference, missense | |
| rs786201036 | Benign | 38,797,285(-) | GAAGA(A/T)GAGGT | nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3600264 | CNV | loss | 21293372 |
| esv3600265 | CNV | loss | 21293372 |
| esv3893918 | CNV | loss | 25118596 |
| nsv594010 | CNV | loss | 21841781 |
| nsv966262 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.47;
71.62% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TLR1 Gene
Disorders for TLR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leprosy 5 |
|
|
| lyme disease |
|
|
| melioidosis |
|
|
| penicilliosis |
|
|
| ocular toxoplasmosis |
|
|
Search TLR1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TLR1
No data available for UniProtKB/Swiss-Prot and Genatlas for TLR1 Gene
Publications for TLR1 Gene
- Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. (PMID: 19771452) Velez D.R. … Scott W.K. (Hum. Genet. 2010) 3 22 46 64
- Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. (PMID: 20016852) Hawn T.R. … Hooton T.M. (PLoS ONE 2009) 3 22 46 64
- Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. (PMID: 19456232) Schuring R.P. … Oskam L. (J. Infect. Dis. 2009) 3 4 46 64
- Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. (PMID: 19200604) Verstraelen H. … Temmerman M. (J. Reprod. Immunol. 2009) 3 22 46 64
- Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases. (PMID: 18776592) Mailaparambil B. … Heinzmann A. (Dis. Markers 2008) 3 22 46 64
Products for TLR1 Gene
- R&D Systems Antibodies for TLR1 (TLR1)
- R&D Systems Proteins and Enzymes for TLR1
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for TLR1
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for TLR1
- Custom Assay ServicesOriGene ELISA Kits for TLR1
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TLR1
- Origene Custom Protein Services for TLR1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TLR1
- Browse OriGene Inhibitory RNA Products For TLR1
- OriGene qPCR primer pairs for TLR1
- OriGene CRISPR knockouts for TLR1
- OriGene ORF clones in human for TLR1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for TLR1 in any vector
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- GenScript: Design CRISPR guide RNA sequences for TLR1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TLR1
- Cell Signaling Technology (CST) Antibodies for TLR1 (TLR1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for TLR1
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Enzo Life Sciences proteins for TLR1
- Browse Enzo Life Sciences for kits & assays
- Enzo Life Sciences drugs & compounds for TLR1
- Search Enzo Life Sciences for proteins, assays, substrates, inhibitors & antibodies
- Novus Biologicals Antibodies for TLR1
- Novus Biologicals proteins and lysates for TLR1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for TLR1
- Cloud-Clone Corp. Proteins for TLR1
- Cloud-Clone Corp Assay Kits for TLR1
- Invitrogen Antibodies for TLR1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for TLR1
- Addgene plasmids for TLR1
- antibodies-online Antibodies for TLR1: See all 201
- antibodies-online Kits for TLR1: See all 16
- antibodies-online Proteins for TLR1: See all 13
- Search antibodies-online for peptides
- GeneTex TLR1 antibody for TLR1
- Search GeneTex for Proteins for TLR1
- ViGene Biosciences adenoviral particle packaged cDNA for TLR1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TLR1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TLR1 gene
- Search ViGene Biosciences for TLR1
- Santa Cruz Biotechnology (SCBT) Antibodies for TLR1
- Search Santa Cruz Biotechnology (SCBT) for TLR1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TLR1
- Custom Antibody ServicesProSci Antibodies for TLR1
- Search for TLR1 Proteins at ProSci
- Horizon Cell Lines for TLR1
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLR1
- VectorBuilder custom plasmid, inducible vectors for TLR1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLR1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TLR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer