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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLR1 Gene

protein-coding   GIFtS: 68
GCID: GC04M038797

toll-like receptor 1
 Explore 59 diseases affiliated with
TLR1 via
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 Human Malady Compendium 
Biological research products
for TLR1    

Aliases
for TLR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Toll-Like Receptor 11 2     Toll/Interleukin-1 Receptor-Like Protein2 3
CD2811 2     TIL2 3
Rsc7861     TIL. LPRS52 5
KIAA00121 3     CD281 Antigen3

External Ids:    HGNC: 118471   Entrez Gene: 70962   Ensembl: ENSG000001741257   OMIM: 6011945   UniProtKB: Q153993   

Export aliases for TLR1 gene to outside databases

Previous GC identifers: GC04P039090 GC04M038961 GC04M038632 GC04M038695 GC04M038620 GC04M038474 GC04M038122


Summaries
for TLR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TLR1:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share
structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective
immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at
higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative
polyadenylation site, and/or from alternative splicing, have been noted for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TLR1_HUMAN, Q15399
Function: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and
triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or
lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory
response (By similarity)

Gene Wiki entry for TLR1 (TLR 1)


Genomic Views
for TLR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016297.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR1 gene promoter:
         AP-1   FOXO4   ATF-2   POU3F2 (N-Oct-5b)   c-Jun   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

TLR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M038797:  view genomic region     (about GC identifiers)

Start:
 38,792,298 bp from pter      End:
 38,858,438 bp from pter
Size:
 66,141 bases      Orientation:
 minus strand

Proteins
for TLR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLR1_HUMAN, Q15399 (See protein sequence)
Recommended Name: Toll-like receptor 1 precursor  
Size: 786 amino acids; 90291 Da
Subunit: Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with
TLR2. Ligand binding induces the formation of a heterodimer with TLR2
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle,
phagosome membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=BAA02801.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TLR1:
1FYV (3D)        2Z7X (3D)    
Secondary accessions: D1CS39 D1CS41 O15452 Q32MK3 Q9UG90

Explore the universe of human proteins at neXtProt for TLR1: NX_Q15399

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15399

    • TLR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003254.2  
    ENSEMBL proteins: 
     ENSP00000421259   ENSP00000421856   ENSP00000423017   ENSP00000423725   ENSP00000424894  
     ENSP00000354932  

    Human Recombinant Protein Products: 
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    Novus Biologicals TLR1 Proteins
    Novus Biologicals TLR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLR1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS9435236
    GO:0005887integral to plasma membrane TAS9435236
    GO:0016020membrane NAS11081518
    GO:0030670phagocytic vesicle membrane IEA--
    GO:0035354Toll-like receptor 1-Toll-like receptor 2 protein complex IDA17889651


    TLR1 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for TLR1

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    Uscn ELISAs and CLIAs for TLR1

    Protein Domains /
    Families
    for TLR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLR1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR027190 TLR1
     IPR001611 Leu-rich_rpt
     IPR000157 TIR_dom
     IPR017241 Toll-like_receptor

    Graphical View of Domain Structure for InterPro Entry Q15399

    ProtoNet protein and cluster: Q15399

    2 Blocks protein families:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region


    UniProtKB/Swiss-Prot: TLR1_HUMAN, Q15399
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 19 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 TIR domain


    Function
    for TLR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLR1_HUMAN, Q15399
    Function: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and
    triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or
    lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory
    response (By similarity)

         Genatlas biochemistry entry for TLR1:
    Drosophila transmembrane receptor Toll homolog 1,ubiquitously expressed,with at least two alternatively spliced
    isoforms,tissue specific,maybe involved in morphogenesis and immune defense

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS10426995
    GO:0004888transmembrane signaling receptor activity NAS11081518
    GO:0046982protein heterodimerization activity IDA17889651
    GO:0071723lipopeptide binding ----


    TLR1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TLR1:
     Decreased Wnt reporter activit 

    Animal Models:
         Mouse knock-outs for TLR1: Tlr1tm1Aki Tlr1tm1Flv
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Tlr1):
     immune system 

    TLR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TLR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		Activated TLR4 signalling0.63
    		Toll Like Receptor TLR6:TLR2 Cascade0.78
    		Toll Like Receptor 4 (TLR4) Cascade0.61
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll-Like Receptors Cascades0.53
    		MyD88:Mal cascade initiated on plasma membrane0.78
    2Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    		Inflammasome Activation Pathways0.29
    3Immune response_Bacterial infections in normal airways
    		Immune response_Bacterial infections in normal airways1.00
    		Bacterial infections in CF airways0.78
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    5Beta defensins
    		Beta defensins1.00
    		Defensins0.80

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TLR1
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5 R&D Systems Pathways for TLR1
        Inflammasome Activation Pathways
    IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways
    Th17 Differentiation

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLR1 (see all 8)
        NF-KappaB (p50-p65) Pathway
    Toll-Like Receptors Pathway
    TRAF Pathway
    TREM1 Pathway
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for TLR1
        NF-kappaB Signaling

    1 Tocris Bioscience Pathway for TLR1
        Toll-like Receptor Pathway

    3 GeneGo (Thomson Reuters) Pathways for TLR1
        Immune response Bacterial infections in normal airways
    Immune response TLR signaling pathways
    Bacterial infections in CF airways

    1 BioSystems Pathway for TLR1 
        Toll-like receptor signaling pathway


    2         Kegg Pathways  (Kegg details for TLR1):
        Toll-like receptor signaling pathway
    Tuberculosis


    TLR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for TLR1 (Q153993 ENSP000003549324) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPD1P108093, ENSP000003400194I2D: score=2 STRING: ENSP00000340019
    TLR10Q9BXR53, ENSP000003089254I2D: score=2 STRING: ENSP00000308925
    TRAP1Q129313, ENSP000002469574I2D: score=2 STRING: ENSP00000246957
    TIRAPP587533, ENSP000003764454I2D: score=1 STRING: ENSP00000376445
    TLR9Q9NR963, ENSP000003538744I2D: score=1 STRING: ENSP00000353874
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway ----
    GO:0002282microglial cell activation involved in immune response ----
    GO:0006952defense response ----
    GO:0006954inflammatory response IEA--
    GO:0006955immune response TAS10426995


    TLR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TLR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for TLR1

    Browse Tocris compounds for TLR1
    4 Novoseek chemical compound relationships for TLR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoteichoic acid 73.9 4 14500472 (2), 10364168 (1)
    flagellin 70.4 2 16479520 (1), 19270494 (1)
    peptidoglycan 69.8 9 18424724 (2), 12874299 (1), 16374251 (1), 11254583 (1)
    lipid 0 4 17419716 (1), 17889651 (1)

    Search CenterWatch for drugs/clinical trials and news about TLR1 

    Transcripts
    for TLR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLR1 gene: 
    NM_003263.3  

    Unigene Cluster for TLR1:

    Toll-like receptor 1
    Hs.654532  [show with all ESTs]
    Unigene Representative Sequence: NM_003263
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510552 ENST00000505744 ENST00000502213 ENST00000505940 ENST00000515861
    ENST00000506146 ENST00000508364 ENST00000509754 ENST00000508535 ENST00000308979(uc003gtl.3)


    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB445617.1 AK292982.1 AL050262.1 BC089403.1 BC109093.1 BC109094.1 CR533562.1 D13637.1 
    DQ012254.1 DQ012255.1 DQ012256.1 DQ012257.1 DQ012258.1 DQ012259.1 DQ012260.1 DQ012261.1 
    DQ012262.1 DQ012263.1 DQ012264.1 U88540.1 

    8 DOTS entries:

    DT.210982  DT.121275795  DT.121276009  DT.100740843  DT.121275964  DT.121276003  DT.206550  DT.121275790 

    24/37 AceView cDNA sequences (see all 37):

    CD368967 BU623316 BP375715 D13637 AA251768 NM_003263 CA438677 BU676863 
    CA394039 AW117540 AW967990 U88540 AL050262 BX498528 CR533562 AA953203 
    BQ003287 BX093274 CF121621 AI339155 AL035755 AA886180 AW408740 AI768133 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TLR1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                                                              -                                       
    SP2:                                      -                       -                                       
    SP3:                                            -                 -                                       
    SP4:        -     -     -     -     -           -                                                         
    SP5:                                            -     -     -     -                                       


    ECgene alternative splicing isoforms for TLR1

    Expression
    for TLR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCAGGAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TLR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLR1

    SOURCE GeneReport for Unigene cluster: Hs.654532

    UniProtKB/Swiss-Prot: TLR1_HUMAN, Q15399
    Tissue specificity: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small
    intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR1 (see all 8): 
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              Antigen Presenting Cells in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Inflammatory Response & Autoimmunity in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for TLR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLR1 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves Q5GDB1_CHICK6
    TLR156
    		 toll-like receptor 15
    		 48(a)
    22(a)
    		 1 ↔ many
    possible ortholog
    		 4(71561343-71566607)
    3(2945856-2948462)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 59(a)
    49(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 GL343361.1(163037-164422)
    GL343361.1(130910-133312)
    zebrafish
    (Danio rerio)    		 Actinopterygii tlr16
    		 toll-like receptor 1
    		 34(a)
    		 1 → many
    		 14(733852-738712)
    fruit fly
    (Drosophila melanogaster)    		 Insecta Toll-96
    Tl6
    (see all 5)    		 Toll
    (see all 5)    		 14(a)
    13(a)
    (see all 5)    		 1 ↔ many
    possible ortholog
    (see all 5)    		 3L(20354943-20359824)
    3R(22624765-22668125)


    ENSEMBL Gene Tree for TLR1 (if available)
    TreeFam Gene Tree for TLR1 (if available) 

    Paralogs
    for TLR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLR1 gene
    CD1802  ENSG000001733662  TLR72  TLR92  TLR52  TLR102  LRRC332  TLR42  
    TLR82  TLR62  LRRC322  TLR32  TLR22  
    3 SIMAP similar genes for TLR1 using alignment to 15 protein entries:     TLR1_HUMAN (see all proteins):
    TLR6    TLR10    TLR2

    TLR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TLR1
    PGOHUM00000244664


    Genomic Variants
    for TLR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TLR1_HUMAN, Q15399
    Polymorphism: Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and
    define the leprosy susceptibility locus 5 [MIM:613223]. Ser-602 is a common allele in Caucasians. It is associated
    with impaired cell surface expression and receptor function resulting in protection against leprosy


    Human Gene Mutation Database (HGMD): TLR1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLR1
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    Disorders / Diseases
    for TLR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLR1 for disorders           About GeneDecksing

    OMIM gene information: 601194   
    OMIM disorders: 613223  
    20/59 diseases for TLR1 (see all 59):    About MalaCards
    leprosy, protection against    mycobacterial infection    leprosy    malt lymphoma
    non-hodgkin lymphoma    invasive aspergillosis    bronchiolitis obliterans    lyme disease
    cystic fibrosis lung disease    cystic fibrosis    aspergillosis    hodgkin's lymphoma
    inflammatory bowel disease    melioidosis    atopic dermatitis    bacteriuria
    bronchiolitis    chronic lymphocytic leukemia    lymphocytic leukemia    filariasis

    1 disease from the University of Copenhagen DISEASES database for TLR1:
    Lyme disease

    10/11 Novoseek disease relationships for TLR1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lyme disease 44.1 1 16479520 (1)
    necrosis 29.8 3 16048981 (1), 14500472 (1)
    virus infection 22.7 1 11607792 (1)
    bacterial infections 19.6 1 20153434 (1)
    mycobacterial infection 19.3 1 14687934 (1)
    sepsis 17.7 3 18635889 (2), 15794413 (1)
    malt lymphoma 16.6 1 12519297 (1)
    tumors 6.07 3 16048981 (1), 14500472 (1)
    tuberculosis 3.87 3 17595679 (1), 19636364 (1), 16493059 (1)
    asthma 0 1 18547625 (1)

    Genetic Association Database (GAD): TLR1
    Human Genome Epidemiology (HuGE) Navigator: TLR1 (62 documents)

    Export disorders for TLR1 gene to outside databases

    Publications
    for TLR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLR1 gene, integrated from 9 sources (see all 257):
    (articles sorted by number of sources associating them with TLR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of human receptors structurally related to Drosophila Toll. (PubMed id 9435236)1, 2, 3 Rock F.L.... Bazan J.F. (1998)
    2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (1994)
    3. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. (PubMed id 17889651)1, 2, 9 Jin M.S....Lee J.-O. (2007)
    4. Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. (PubMed id 16374251)1, 4, 9 Pierik M....Vermeire S. (2006)
    5. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. (PubMed id 11081518)1, 2, 9 Xu Y.... Tong L. (2000)
    6. Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. (PubMed id 19456232)1, 2 Schuring R.P....Oskam L. (2009)
    7. The heterogeneous allelic repertoire of human toll-li ke receptor (TLR) genes. (PubMed id 19924287)1, 2 Georgel P....Bahram S. (2009)
    8. Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. (PubMed id 17548585)1, 2 Johnson C.M....Tapping R.I. (2007)
    9. Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. (PubMed id 16081826)1, 4 Schroder N.W....Schumann R.R. (2005)
    10. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. (PubMed id 15812078)1, 4 Sun J....Gronberg H. (2005)

    External Searches for TLR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TLR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7096 HGNC: 11847 AceView: TLR1 Ensembl:ENSG00000174125 euGenes: HUgn7096
    ECgene: TLR1 Kegg: 7096 H-InvDB: TLR1

    Other Databases showing TLR1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0012

    Specialized Databases showing TLR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLR1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TLR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLR1 gene:
    Search GeneIP for patents involving TLR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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