Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLR1 Gene

Aliases for TLR1 Gene

  • Toll-Like Receptor 1 2 3
  • Toll/Interleukin-1 Receptor-Like Protein 3 4
  • TIL. LPRS5 3 6
  • TIL 3 4
  • CD281 Antigen 4
  • KIAA0012 4
  • Rsc786 3
  • CD281 3

External Ids for TLR1 Gene

Previous GeneCards Identifiers for TLR1 Gene

  • GC04P039090
  • GC04M038961
  • GC04M038632
  • GC04M038695
  • GC04M038620
  • GC04M038474
  • GC04M038122

Summaries for TLR1 Gene

Entrez Gene Summary for TLR1 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLR1 Gene

TLR1 (Toll-Like Receptor 1) is a Protein Coding gene. Diseases associated with TLR1 include leprosy 5 and ocular toxoplasmosis. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is TLR6.

UniProtKB/Swiss-Prot for TLR1 Gene

  • Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Tocris Summary for TLR1 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like receptors are activated by molecules associated with biological threat and are highly specific towards evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR1 Gene

Genomics for TLR1 Gene

Regulatory Elements for TLR1 Gene

Genomic Location for TLR1 Gene

Start:
38,790,677 bp from pter
End:
38,856,817 bp from pter
Size:
66,141 bases
Orientation:
Minus strand

Genomic View for TLR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR1 Gene

Proteins for TLR1 Gene

  • Protein details for TLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15399-TLR1_HUMAN
    Recommended name:
    Toll-like receptor 1
    Protein Accession:
    Q15399
    Secondary Accessions:
    • D1CS39
    • D1CS41
    • O15452
    • Q32MK3
    • Q32MK4
    • Q9UG90

    Protein attributes for TLR1 Gene

    Size:
    786 amino acids
    Molecular mass:
    90291 Da
    Quaternary structure:
    • Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.
    SequenceCaution:
    • Sequence=BAA02801.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TLR1 Gene

neXtProt entry for TLR1 Gene

Proteomics data for TLR1 Gene at MOPED

Post-translational modifications for TLR1 Gene

  • Glycosylation at Asn51, Asn137, Asn163, Asn330, Asn429, and Asn578
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR1 Gene

No data available for DME Specific Peptides for TLR1 Gene

Domains for TLR1 Gene

Gene Families for TLR1 Gene

HGNC:
  • CD :CD molecules
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q15399

UniProtKB/Swiss-Prot:

TLR1_HUMAN :
  • Q15399
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 TIR domain.
Family:
  • Belongs to the Toll-like receptor family.
Similarity:
  • Contains 19 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TLR1: view

Function for TLR1 Gene

Molecular function for TLR1 Gene

GENATLAS Biochemistry: Drosophila transmembrane receptor Toll homolog 1,ubiquitously expressed,with at least two alternatively spliced isoforms,tissue specific,maybe involved in morphogenesis and immune defense
UniProtKB/Swiss-Prot Function: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Gene Ontology (GO) - Molecular Function for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10426995
GO:0004888 transmembrane signaling receptor activity NAS 11081518
GO:0005515 protein binding --
GO:0046982 protein heterodimerization activity IDA 17889651
genes like me logo Genes that share ontologies with TLR1: view

Phenotypes for TLR1 Gene

MGI mutant phenotypes for TLR1:
inferred from 2 alleles
GenomeRNAi human phenotypes for TLR1:
genes like me logo Genes that share phenotypes with TLR1: view

Animal Models for TLR1 Gene

MGI Knock Outs for TLR1:

miRNA for TLR1 Gene

miRTarBase miRNAs that target TLR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TLR1 Gene

Localization for TLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR1 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLR1 Gene COMPARTMENTS Subcellular localization image for TLR1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
extracellular 2
nucleus 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 9435236
GO:0005887 integral component of plasma membrane TAS 9435236
GO:0016020 membrane NAS 11081518
GO:0016021 integral component of membrane --
GO:0030670 phagocytic vesicle membrane IEA --
genes like me logo Genes that share ontologies with TLR1: view

Pathways for TLR1 Gene

genes like me logo Genes that share pathways with TLR1: view

Gene Ontology (GO) - Biological Process for TLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA --
GO:0006952 defense response --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 10426995
genes like me logo Genes that share ontologies with TLR1: view

Compounds for TLR1 Gene

(5) Tocris Compounds for TLR1 Gene

Compound Action Cas Number
C34 TLR4 inhibitor [40592-88-9]
CU CPT 4a Selective TLR3 inhibitor [1279713-77-7]
Pam3CSK4 TLR1/2 agonist; induces cytokine production [112208-00-1]
Poly(I:C) TLR3 agonist [24939-03-5]
Resiquimod Toll-like receptor 7 (TLR7) agonist [144875-48-9]

(4) Novoseek inferred chemical compound relationships for TLR1 Gene

Compound -log(P) Hits PubMed IDs
lipoteichoic acid 73.9 3
flagellin 70.4 2
peptidoglycan 69.8 5
lipid 0 2
genes like me logo Genes that share compounds with TLR1: view

Transcripts for TLR1 Gene

Unigene Clusters for TLR1 Gene

Toll-like receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: -
SP8: - - - - -

Relevant External Links for TLR1 Gene

GeneLoc Exon Structure for
TLR1
ECgene alternative splicing isoforms for
TLR1

Expression for TLR1 Gene

mRNA expression in normal human tissues for TLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR1 Gene

This gene is overexpressed in Whole Blood (26.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TLR1 Gene

SOURCE GeneReport for Unigene cluster for TLR1 Gene Hs.654532

mRNA Expression by UniProt/SwissProt for TLR1 Gene

Q15399-TLR1_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine
genes like me logo Genes that share expressions with TLR1: view

Orthologs for TLR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR1 35
  • 99.24 (n)
  • 98.35 (a)
TLR1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLR1 35
  • 85.54 (n)
  • 79.85 (a)
TLR1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlr1 35
  • 77.1 (n)
  • 74.07 (a)
Tlr1 16
Tlr1 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tlr1 35
  • 78.42 (n)
  • 73.44 (a)
chicken
(Gallus gallus)
Aves TLR1LA 36
  • 48 (a)
ManyToMany
TLR1LB 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tlr1 35
  • 54.94 (n)
  • 44.93 (a)
zebrafish
(Danio rerio)
Actinopterygii tlr1 35
  • 48.05 (n)
  • 37.69 (a)
tlr1 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Toll-9 36
  • 18 (a)
OneToMany
Species with no ortholog for TLR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR1 Gene

ENSEMBL:
Gene Tree for TLR1 (if available)
TreeFam:
Gene Tree for TLR1 (if available)

Paralogs for TLR1 Gene

Paralogs for TLR1 Gene

Pseudogenes.org Pseudogenes for TLR1 Gene

genes like me logo Genes that share paralogs with TLR1: view

Variants for TLR1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR1 Gene

Q15399-TLR1_HUMAN
Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIM:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy

Sequence variations from dbSNP and Humsavar for TLR1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs184183 -- 38,806,006(+) GGAGG(A/G)AAGTG upstream-variant-2KB
rs380121 -- 38,806,224(-) AGGTT(G/T)TGTTA upstream-variant-2KB
rs395458 -- 38,806,855(-) ggtag(A/G)ggtag upstream-variant-2KB
rs437996 -- 38,806,118(+) TGTCT(C/G)TGCCC upstream-variant-2KB
rs452892 -- 38,806,051(+) AATTC(C/G)TGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TLR1 Gene

Variant ID Type Subtype PubMed ID
dgv5526n71 CNV Loss 21882294

Relevant External Links for TLR1 Gene

HapMap Linkage Disequilibrium report
TLR1
Human Gene Mutation Database (HGMD)
TLR1

Disorders for TLR1 Gene

(1) OMIM Diseases for TLR1 Gene (601194)

(1) University of Copenhagen DISEASES for TLR1 Gene

(11) Novoseek inferred disease relationships for TLR1 Gene

Disease -log(P) Hits PubMed IDs
lyme disease 44.1 1
necrosis 29.8 2
virus infection 22.7 1
bacterial infections 19.6 1
mycobacterial infection 19.3 1

Relevant External Links for TLR1

Genetic Association Database (GAD)
TLR1
Human Genome Epidemiology (HuGE) Navigator
TLR1
genes like me logo Genes that share disorders with TLR1: view

No data available for UniProtKB/Swiss-Prot for TLR1 Gene

Publications for TLR1 Gene

  1. Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. (PMID: 16374251) Pierik M. … Vermeire S. (Inflamm. Bowel Dis. 2006) 3 23 48
  2. TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. (PMID: 16461792) Kesh S. … Papanicolaou G.A. (Ann. N. Y. Acad. Sci. 2005) 3 23 48
  3. Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease. (PMID: 17595233) Henckaerts L. … Vermeire S. (Gut 2007) 3 23 48
  4. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. (PMID: 17889651) Jin M.S. … Lee J.-O. (Cell 2007) 3 4 23
  5. Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk. (PMID: 18752252) Stevens V.L. … Rodriguez C. (Int. J. Cancer 2008) 3 23 48

Products for TLR1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antibacterial Response in human,mouse,rat
    • Antigen Presenting Cells in human,mouse,rat
    • Inflammatory Response & Autoimmunity in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat
    • Innate & Adaptive Immune Responses in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TLR1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TLR1
    • Block miRNA regulation of TLR1 using miScript Target Protectors
    • Addgene plasmids for TLR1

    Sources for TLR1 Gene

    Back to Top

    Content