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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLN2 Gene

protein-coding   GIFtS: 60
GCID: GC15P062682

Talin 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Talin 21 2
KIAA03203 5
ILWEQ2
talin-22

External Ids:    HGNC: 154471   Entrez Gene: 836602   Ensembl: ENSG000001719147   OMIM: 6073495   UniProtKB: Q9Y4G63   

Export aliases for TLN2 gene to outside databases

Previous GC identifers: GC15P058780 GC15P055987 GC15P060518 GC15P060655 GC15P060726 GC15P062939 GC15P039762


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLN2 Gene:
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the
assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and
osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought
to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the
actin cytoskeleton. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLN2 Gene: 
TLN2 (talin 2) is a protein-coding gene. Diseases associated with TLN2 include temporal lobe epilepsy, and among its related super-pathways are Cell adhesion Integrin-mediated cell adhesion and migration and FAK1 Signaling. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is HIP1.

UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6
Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play
an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase
activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLN2 gene promoter:
         TBP   RP58   AML1a   CHOP-10   AREB6   S8   POU2F1   POU2F1a   SEF-1 (1)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15-q21   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q15-q21

TLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLN2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P062682:  view genomic region     (about GC identifiers)

Start:
62,682,725 bp from pter      End:
63,136,830 bp from pter
Size:
454,106 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6 (See protein sequence)
Recommended Name: Talin-2  
Size: 2542 amino acids; 271613 Da
Subunit: Interacts directly with PIP5K1C
Subcellular location: Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane
protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses
Secondary accessions: A6NLB8

Explore the universe of human proteins at neXtProt for TLN2: NX_Q9Y4G6

Explore proteomics data for TLN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4G6

  • TLN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLN2 Protein Expression
    REFSEQ proteins: NP_055874.2  
    ENSEMBL proteins: 
     ENSP00000453508   ENSP00000453730   ENSP00000453812   ENSP00000303476  

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    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction IC15494027

    TLN2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/13 InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR006077 Vinculin/catenin
     IPR002558 ILWEQ_dom
     IPR015224 Talin_cent
     IPR002404 Insln_rcpt_S1

    Graphical View of Domain Structure for InterPro Entry Q9Y4G6

    ProtoNet protein and cluster: Q9Y4G6

    2 Blocks protein domains:
    IPB000299 Band 4.1 domain
    IPB002558 I/LWEQ domain


    UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 I/LWEQ domain


    TLN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLN2_HUMAN, Q9Y4G6
    Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play
    an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase
    activity (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS10320934
    GO:0005158insulin receptor binding IEA--
    GO:0005198structural molecule activity NAS10320934
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding IPI10320934
         
    TLN2 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tln2):
     behavior/neurological  cellular  mortality/aging  muscle  normal 

    TLN2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TLN2: Tln2tm1.1Crit Tln2tm2Crit

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLN2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    Cytoskeleton remodeling Integrin outside-in signaling0.37
    2Integrin Pathway
    Integrin Pathway0.67
    FAK1 Signaling0.67
    3GPCR Pathway
    Paxillin Interactions0.73
    4Focal Adhesion
    Focal adhesion0.64
    5Rho Family GTPases
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for TLN2
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cytoskeleton remodeling FAK signaling
    Cell adhesion Integrin inside-out signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLN2 (see all 6)
        MAPK Signaling
    RhoA Pathway
    Paxillin Interactions
    Integrin Pathway
    Calpain Protease Regulates Cellular Mechanics

    5/6 GeneGo (Thomson Reuters) Pathways for TLN2 (see all 6)
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling FAK signaling


    2         Kegg Pathways  (Kegg details for TLN2):
        Focal adhesion
    HTLV-I infection


    TLN2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/583 Interacting proteins for TLN2 (Q9Y4G62, 3 ENSP000003034764) via UniProtKB, MINT, STRING, and/or I2D (see all 583)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-7226309 MINT-7226142 MINT-7226210 I2D: score=1 STRING: ENSP00000361423
    ITGB2P051072, 3, ENSP000003032424MINT-7226365 MINT-7226134 MINT-7226171 MINT-7226150 MINT-7226403 I2D: score=1 STRING: ENSP00000303242
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    PIP5K1CO603313, ENSP000003353334I2D: score=2 STRING: ENSP00000335333
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007016cytoskeletal anchoring at plasma membrane IEA--
    GO:0007043cell-cell junction assembly TAS15494027
    GO:0007155cell adhesion NAS11907066

    TLN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLN2

    Search CenterWatch for drugs/clinical trials and news about TLN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLN2 gene: 
    NM_015059.2  

    Unigene Clusters for TLN2:

    Talin 2
    Hs.569438  [show with all ESTs], Hs.610975
    Unigene Representative Sequences: NM_015059, AL122065
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561322 ENST00000561197 ENST00000561311 ENST00000474847 ENST00000494733
    ENST00000559908 ENST00000489129 ENST00000472902(uc002ald.3) ENST00000467297
    ENST00000559174 ENST00000306829(uc002alb.4 uc002alc.4 uc010uic.2)

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    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate TLN2 (see all 57):
    hsa-miR-345 hsa-miR-300 hsa-miR-429 hsa-miR-146a hsa-miR-938 hsa-let-7a-2* hsa-miR-624 hsa-miR-4314
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    Additional mRNA sequence: AL122065.1 

    7 DOTS entries:

    DT.100754091  DT.455182  DT.95214510  DT.40229939  DT.121070150  DT.75107131  DT.431249 

    3 AceView cDNA sequences:

    AL122065 AL042061 BF737572 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TLN2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
    SP1:                          -                                         -                                                     -                                 
    SP2:                                                                    -                                                     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b · 54c
    SP1:                                            -                 -                                 
    SP2:                                            -                 -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                            -                                                   


    ECgene alternative splicing isoforms for TLN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGTTATT
    TLN2 Expression
    About this image


    See TLN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLN2

    SOURCE GeneReport for Unigene clusters: Hs.569438 Hs.610975
        SABiosciences Expression via Pathway-Focused PCR Array including TLN2: 
              Adherens Junctions in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TLN2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tln21 , 5 talin 21, 5 89.68(n)1
    98.7(a)1
      9 (36.39 cM)5
    705491  NM_001081242.21  NP_001074711.21 
     672170875 
    chicken
    (Gallus gallus)
    Aves TLN21 talin 2 81.39(n)
    96.14(a)
      415374  XM_003641877.1  XP_003641925.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLN26
    Uncharacterized protein
    94(a)
    1 ↔ 1
    GL344433.1(312-29691)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20372 Xenopus laevis transcribed sequence with moderate similarity to protein spQ9Y490 (H.sapiens) TALI_HUMAN TALIN less 76.53(n)    BX845985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636132 similar to talin 2 79.93(n)   394168  BC055166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rhea1 CG6831-PA 54.12(n)
    48.5(a)
      38978  NM_139981.3  NP_648238.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G12B.111 Protein Y71G12B.11 47.49(n)
    39.68(a)
      171736  NM_058485.4  NP_490886.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SLA26
    Transmembrane actin-binding protein involved in me...
    16(a)
    1 → many
    XIV(188051-190957)


    ENSEMBL Gene Tree for TLN2 (if available)
    TreeFam Gene Tree for TLN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLN2 gene
    HIP12  HIP1R2  MESDC12  TLN12  
    1 SIMAP similar gene for TLN2 using alignment to 4 protein entries:     TLN2_HUMAN (see all proteins):
    TLN1

    TLN2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TLN2
    PGOHUM00000246004


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5028 SNPs in TLN2 are shown (see all 5028)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727558401,2
    C,F--62939417(+) TTTTTC/TTCCCC 1 -- us2k10--------
    rs1911919091,2
    --62939434(+) AATTAC/TTATCG 1 -- us2k10--------
    rs9389791,2
    C,F,A,H--62939440(+) TATCGC/TGAACA 1 -- us2k134Minor allele frequency- N:0.00EA NA NS WA CSA 4479
    rs1998348071,2
    C--62939462(+) CTCTTC/TGTGTT 1 -- us2k10--------
    rs1445275791,2
    C--62939551(+) TGCAAC/TGTGGT 2 N syn11Minor allele frequency- T:0.00NA 4552
    rs1825563461,2
    C--62939598(+) CGATGC/TGTGTC 2 A V mis10--------
    rs1485352281,2
    --62939712(+) TAAAGA/GGACAG 1 -- int10--------
    rs1117131111,2
    F--62939715(+) AGAGAC/TAGAGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs3742121521,2
    C--62939809(+) AGACT-/TGTGATT 1 -- int10--------
    rs1902802711,2
    --62939852(+) TGTCAC/TTGTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TLN2 (62682725 - 62932725 bp, first 250kb of TLN2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for TLN2 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672262CNV Deletion23128226
    esv2749767CNV Deletion23290073
    esv2749766CNV Deletion23290073
    esv2054160CNV Deletion18987734
    esv2913CNV Deletion18987735
    esv2749768CNV Deletion23290073
    esv2749769CNV Deletion23290073
    esv1566775CNV Insertion17803354
    nsv1561CNV Insertion18451855
    esv271833CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607349    OMIM disorders: --

    2 diseases for TLN2:    About MalaCards
    temporal lobe epilepsy    


    TLN2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TLN2
    Human Genome Epidemiology (HuGE) Navigator: TLN2 (1 document)

    Export disorders for TLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLN2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with TLN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the mammalian talin2 gene TLN2. (PubMed id 11527381)1, 2, 3 Monkley S.J....Critchley D.R. (2001)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. (PubMed id 12422219)1, 2 Di Paolo G.... De Camilli P. (2002)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. (PubMed id 19109932)1, 9 Xiao F....Wang X.F. (2009)
    8. Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle. (PubMed id 17183545)1, 9 Senetar M.A....McCann R.O. (2007)
    9. Talin1 has unique expression versus talin 2 in the hea rt and modifies the hypertrophic response to pressure overload. (PubMed id 23266827)1 Manso A.M....Ross R.S. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83660 HGNC: 15447 AceView: TLN2.2 Ensembl:ENSG00000171914 euGenes: HUgn83660
    ECgene: TLN2 Kegg: 83660 H-InvDB: TLN2

    (According to HUGE)
    About This Section
    HUGE: KIAA0320

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLN2 gene:
    Search GeneIP for patents involving TLN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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