Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLN2 Gene

Aliases for TLN2 Gene

  • Talin 2 2 3
  • KIAA0320 4 6
  • Talin-2 3
  • ILWEQ 3

External Ids for TLN2 Gene

Previous GeneCards Identifiers for TLN2 Gene

  • GC15P058780
  • GC15P055987
  • GC15P060518
  • GC15P060655
  • GC15P060726
  • GC15P062939
  • GC15P039762
  • GC15P062682

Summaries for TLN2 Gene

Entrez Gene Summary for TLN2 Gene

  • This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLN2 Gene

TLN2 (Talin 2) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and ERK Signaling. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is HIP1.

UniProtKB/Swiss-Prot for TLN2 Gene

  • As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLN2 Gene

Genomics for TLN2 Gene

Regulatory Elements for TLN2 Gene

Genomic Location for TLN2 Gene

Start:
62,390,526 bp from pter
End:
62,844,631 bp from pter
Size:
454,106 bases
Orientation:
Plus strand

Genomic View for TLN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLN2 Gene

Proteins for TLN2 Gene

  • Protein details for TLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4G6-TLN2_HUMAN
    Recommended name:
    Talin-2
    Protein Accession:
    Q9Y4G6
    Secondary Accessions:
    • A6NLB8

    Protein attributes for TLN2 Gene

    Size:
    2542 amino acids
    Molecular mass:
    271613 Da
    Quaternary structure:
    • Interacts directly with PIP5K1C

neXtProt entry for TLN2 Gene

Proteomics data for TLN2 Gene at MOPED

Post-translational modifications for TLN2 Gene

  • Ubiquitination at Lys1543
  • Modification sites at PhosphoSitePlus

Other Protein References for TLN2 Gene

Antibody Products

No data available for DME Specific Peptides for TLN2 Gene

Domains for TLN2 Gene

Suggested Antigen Peptide Sequences for TLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4G6

UniProtKB/Swiss-Prot:

TLN2_HUMAN :
  • Q9Y4G6
Domain:
  • Contains 1 FERM domain.
  • Contains 1 I/LWEQ domain.
genes like me logo Genes that share domains with TLN2: view

No data available for Gene Families for TLN2 Gene

Function for TLN2 Gene

Molecular function for TLN2 Gene

UniProtKB/Swiss-Prot Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

Gene Ontology (GO) - Molecular Function for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding NAS 10320934
GO:0005158 insulin receptor binding IEA --
GO:0005198 structural molecule activity NAS 10320934
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 10320934
genes like me logo Genes that share ontologies with TLN2: view
genes like me logo Genes that share phenotypes with TLN2: view

Animal Models for TLN2 Gene

MGI Knock Outs for TLN2:

Animal Model Products

CRISPR Products

miRNA for TLN2 Gene

miRTarBase miRNAs that target TLN2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TLN2 Gene

Localization for TLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLN2 Gene

Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLN2 Gene COMPARTMENTS Subcellular localization image for TLN2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton --
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IC 15494027
genes like me logo Genes that share ontologies with TLN2: view

Pathways for TLN2 Gene

genes like me logo Genes that share pathways with TLN2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007016 cytoskeletal anchoring at plasma membrane IEA --
GO:0007043 cell-cell junction assembly TAS 15494027
GO:0007155 cell adhesion NAS 11907066
genes like me logo Genes that share ontologies with TLN2: view

Transcripts for TLN2 Gene

mRNA/cDNA for TLN2 Gene

(13) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLN2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TLN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b · 54c
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:

Relevant External Links for TLN2 Gene

GeneLoc Exon Structure for
TLN2
ECgene alternative splicing isoforms for
TLN2

Expression for TLN2 Gene

mRNA expression in normal human tissues for TLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLN2 Gene

SOURCE GeneReport for Unigene cluster for TLN2 Gene Hs.569438

genes like me logo Genes that share expressions with TLN2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TLN2 Gene

Orthologs for TLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLN2 35
  • 99.54 (n)
  • 99.69 (a)
TLN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLN2 35
  • 90.78 (n)
  • 98.74 (a)
TLN2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLN2 35
  • 91.77 (n)
  • 99.13 (a)
TLN2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tln2 35
  • 89.68 (n)
  • 98.7 (a)
Tln2 16
Tln2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLN2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLN2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tln2 35
  • 89.64 (n)
  • 98.62 (a)
chicken
(Gallus gallus)
Aves TLN2 35
  • 81.39 (n)
  • 96.14 (a)
TLN2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLN2 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2037 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tln2 35
  • 76.75 (n)
  • 90.66 (a)
zebrafish
(Danio rerio)
Actinopterygii TLN2 (2 of 2) 36
  • 86 (a)
OneToMany
tln2a 35
  • 75.63 (n)
  • 86.93 (a)
tln2a 36
  • 87 (a)
OneToMany
zgc63613 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007474 35
  • 55.25 (n)
  • 51.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta rhea 35
  • 54.23 (n)
  • 48.74 (a)
rhea 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tln-1 36
  • 38 (a)
OneToOne
Y71G12B.11 35
  • 48.24 (n)
  • 40.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5889 36
  • 58 (a)
OneToOne
Species with no ortholog for TLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLN2 Gene

ENSEMBL:
Gene Tree for TLN2 (if available)
TreeFam:
Gene Tree for TLN2 (if available)

Paralogs for TLN2 Gene

Paralogs for TLN2 Gene

Selected SIMAP similar genes for TLN2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TLN2 Gene

genes like me logo Genes that share paralogs with TLN2: view

Variants for TLN2 Gene

Sequence variations from dbSNP and Humsavar for TLN2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs192625 -- 62,404,090(+) TTCCA(A/G)ACTTG intron-variant
rs289103 -- 62,389,586(+) AGATA(A/G)GGTCT upstream-variant-2KB
rs289104 -- 62,391,251(+) TCTCC(A/G)GTGCC intron-variant, upstream-variant-2KB
rs289139 -- 62,404,928(-) TAAAC(A/G)TCCTG intron-variant
rs289140 -- 62,405,310(-) CTCTA(C/T)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLN2 Gene

Variant ID Type Subtype PubMed ID
esv2749766 CNV Deletion 23290073
esv2054160 CNV Deletion 18987734
esv2913 CNV Deletion 18987735
esv2749767 CNV Deletion 23290073
esv2672262 CNV Deletion 23128226
esv2749768 CNV Deletion 23290073
esv2749769 CNV Deletion 23290073
nsv1561 CNV Insertion 18451855
nsv833032 CNV Loss 17160897
esv1566775 CNV Insertion 17803354
esv271833 CNV Insertion 20981092
nsv904303 CNV Loss 21882294
nsv1562 CNV Insertion 18451855
nsv94552 CNV Insertion 16902084

Relevant External Links for TLN2 Gene

HapMap Linkage Disequilibrium report
TLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLN2 Gene

Disorders for TLN2 Gene

Relevant External Links for TLN2

Genetic Association Database (GAD)
TLN2
Human Genome Epidemiology (HuGE) Navigator
TLN2
genes like me logo Genes that share disorders with TLN2: view

No data available for UniProtKB/Swiss-Prot for TLN2 Gene

Publications for TLN2 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Analysis of the mammalian talin2 gene TLN2. (PMID: 11527381) Monkley S.J. … Critchley D.R. (Biochem. Biophys. Res. Commun. 2001) 2 3 4
  3. Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle. (PMID: 17183545) Senetar M.A. … McCann R.O. (Cell Motil. Cytoskeleton 2007) 3 23
  4. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. (PMID: 19109932) Xiao F. … Wang X.F. (Brain Res. 2009) 3 23
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for TLN2 Gene

Sources for TLN2 Gene

Back to Top

Content