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TLN2 Gene

protein-coding   GIFtS: 60
GCID: GC15P062682

Talin 2

  Search for TLN2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Talin 21 2
KIAA03203 5
ILWEQ2
talin-22

External Ids:    HGNC: 154471   Entrez Gene: 836602   Ensembl: ENSG000001719147   OMIM: 6073495   UniProtKB: Q9Y4G63   

Export aliases for TLN2 gene to outside databases

Previous GC identifers: GC15P058780 GC15P055987 GC15P060518 GC15P060655 GC15P060726 GC15P062939 GC15P039762


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLN2 Gene:
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the
assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and
osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought
to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the
actin cytoskeleton. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLN2 Gene:
TLN2 (talin 2) is a protein-coding gene. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is HIP1.

UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6
Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play
an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase
activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLN2 gene promoter:
         TBP   RP58   AML1a   CHOP-10   AREB6   S8   POU2F1   POU2F1a   SEF-1 (1)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLN2 promoter sequence
   Search Chromatin IP Primers for TLN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15-q21   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q15-q21

TLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLN2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P062682:  view genomic region     (about GC identifiers)

Start:
62,682,725 bp from pter      End:
63,136,830 bp from pter
Size:
454,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6 (See protein sequence)
Recommended Name: Talin-2  
Size: 2542 amino acids; 271613 Da
Subunit: Interacts directly with PIP5K1C
Secondary accessions: A6NLB8

Explore the universe of human proteins at neXtProt for TLN2: NX_Q9Y4G6

Explore proteomics data for TLN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1543
  • Modification sites at PhosphoSitePlus

  • See TLN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055874.2  
    ENSEMBL proteins: 
     ENSP00000453508   ENSP00000453730   ENSP00000453812   ENSP00000303476  

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    Cloud-Clone Corp. Proteins for TLN2

     
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    Abcam antibodies for TLN2 (Q9Y4G6, Q9Y490)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR006077 Vinculin/catenin
     IPR002558 ILWEQ_dom
     IPR015224 Talin_cent
     IPR002404 Insln_rcpt_S1

    Graphical View of Domain Structure for InterPro Entry Q9Y4G6

    ProtoNet protein and cluster: Q9Y4G6

    2 Blocks protein domains:
    IPB000299 Band 4.1 domain
    IPB002558 I/LWEQ domain


    UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 I/LWEQ domain


    Find genes that share domains with TLN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLN2_HUMAN, Q9Y4G6
    Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play
    an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase
    activity (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS10320934
    GO:0005158insulin receptor binding IEA--
    GO:0005198structural molecule activity NAS10320934
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding IPI10320934
         
    Find genes that share ontologies with TLN2           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tln2):
     behavior/neurological  cellular  mortality/aging  muscle  normal 

    Find genes that share phenotypes with TLN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TLN2: Tln2tm1.1Crit Tln2tm2Crit

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLN2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLN2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLN2

    miRNA
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    miRTarBase miRNAs that target TLN2:
    hsa-mir-194-5p (MIRT006999), hsa-mir-132-3p (MIRT007253)

    Block miRNA regulation of human, mouse, rat TLN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLN2 (see all 57):
    hsa-miR-345 hsa-miR-300 hsa-miR-429 hsa-miR-146a hsa-miR-938 hsa-let-7a-2* hsa-miR-624 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidTLN2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLN2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLN2_HUMAN, Q9Y4G6: Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane
    protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton ----
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction IC15494027

    Find genes that share ontologies with TLN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLN2 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    Cytoskeleton remodeling Integrin outside in signaling0.37
    2Integrin Pathway
    FAK1 Signaling0.67
    Integrin Pathway0.67
    3GPCR Pathway
    Paxillin Interactions0.73
    4Focal adhesion
    Focal adhesion0.65
    5ERK Signaling
    MAPK Signaling0.58


    Find genes that share SuperPaths with TLN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TLN2 (see all 6)
        MAPK Signaling
    RhoA Pathway
    Paxillin Interactions
    Integrin Pathway
    Calpain Protease Regulates Cellular Mechanics

    Selected GeneGo (Thomson Reuters) Pathways for TLN2 (see all 6)
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling FAK signaling


    3 Kegg Pathways  (Kegg details for TLN2):
        Rap1 signaling pathway
    Focal adhesion
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Array including TLN2: 
              Adherens Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TLN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLN2 (Q9Y4G61, 2, 3 ENSP000003034764) via UniProtKB, MINT, STRING, and/or I2D (see all 583)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005191, 2, 3, ENSP000003614234EBI-1220811,EBI-375543 MINT-7226309 MINT-7226142 MINT-7226210 I2D: score=1 STRING: ENSP00000361423
    ITGB2P051071, 2, 3, ENSP000003032424EBI-1220811,EBI-300173 MINT-7226365 MINT-7226134 MINT-7226171 MINT-7226150 MINT-7226403 I2D: score=1 STRING: ENSP00000303242
    ALBP027683, ENSP000002958974I2D: score=1 STRING: ENSP00000295897
    PIP5K1CO603313, ENSP000003353334I2D: score=2 STRING: ENSP00000335333
    CDC5LQ994592, ENSP000003605324MINT-7947479 STRING: ENSP00000360532
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007016cytoskeletal anchoring at plasma membrane IEA--
    GO:0007043cell-cell junction assembly TAS15494027
    GO:0007155cell adhesion NAS11907066

    Find genes that share ontologies with TLN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLN2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLN2 gene: 
    NM_015059.2  

    Unigene Clusters for TLN2:

    Talin 2
    Hs.569438  [show with all ESTs], Hs.610975
    Unigene Representative Sequences: NM_015059, AL122065
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561322 ENST00000561197 ENST00000561311 ENST00000474847 ENST00000494733
    ENST00000559908 ENST00000489129 ENST00000472902(uc002ald.3) ENST00000467297
    ENST00000559174 ENST00000306829(uc002alb.4 uc002alc.4 uc010uic.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TLN2 (see all 57):
    hsa-miR-345 hsa-miR-300 hsa-miR-429 hsa-miR-146a hsa-miR-938 hsa-let-7a-2* hsa-miR-624 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidTLN2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TLN2

    Additional mRNA sequence: AL122065.1 

    7 DOTS entries:

    DT.100754091  DT.455182  DT.95214510  DT.40229939  DT.121070150  DT.75107131  DT.431249 

    3 AceView cDNA sequences:

    AL122065 AL042061 BF737572 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TLN2 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
    SP1:                          -                                         -                                                     -                                 
    SP2:                                                                    -                                                     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b · 54c
    SP1:                                            -                 -                                 
    SP2:                                            -                 -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                            -                                                   


    ECgene alternative splicing isoforms for TLN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGGTTATT
    TLN2 Expression
    About this image


    TLN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Gonad
             Primordial germ cell-like cells
     
     Kidney (Urinary System)
    TLN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLN2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.569438 Hs.610975
        Pathway & Disease-focused RT2 Profiler PCR Array including TLN2: 
              Adherens Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TLN2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tln21 , 5 talin 21, 5 89.68(n)1
    98.7(a)1
      9 (36.39 cM)5
    705491  NM_001081242.21  NP_001074711.21 
     672170875 
    chicken
    (Gallus gallus)
    Aves TLN21 talin 2 81.39(n)
    96.14(a)
      415374  XM_003641877.2  XP_003641925.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLN26
    talin 2
    94(a)
    1 ↔ 1
    GL344433.1(312-29691)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20372 Xenopus laevis transcribed sequence with moderate similarity more 76.53(n)    BX845985.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc636132 similar to talin 2 79.93(n)   394168  BC055166.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rhea1 rhea 54.23(n)
    48.74(a)
      38978  NM_001259745.2  NP_001246674.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G12B.111 Y71G12B.11 48.24(n)
    40.54(a)
      171736  NM_058485.5  NP_490886.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SLA26
    Transmembrane actin-binding protein involved in me...
    19(a)
    1 → many
    XIV(188051-190957) YNL243W


    ENSEMBL Gene Tree for TLN2 (if available)
    TreeFam Gene Tree for TLN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLN2 gene
    HIP12  HIP1R2  MESDC12  TLN12  
    1 SIMAP similar gene for TLN2 using alignment to 4 protein entries:     TLN2_HUMAN (see all proteins):
    TLN1

    Find genes that share paralogs with TLN2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TLN2
    PGOHUM00000246004


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLN2 (see all 5028)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727558401,2
    C,F--62939417(+) TTTTTC/TTCCCC 1 -- us2k10--------
    rs1911919091,2
    --62939434(+) AATTAC/TTATCG 1 -- us2k10--------
    rs9389791,2
    C,F,A,H--62939440(+) TATCGC/TGAACA 1 -- us2k134Minor allele frequency- N:0.00EA NA NS WA CSA 4479
    rs1998348071,2
    C--62939462(+) CTCTTC/TGTGTT 1 -- us2k10--------
    rs1445275791,2
    C--62939551(+) TGCAAC/TGTGGT 2 N syn11Minor allele frequency- T:0.00NA 4552
    rs1825563461,2
    C--62939598(+) CGATGC/TGTGTC 2 A V mis10--------
    rs1485352281,2
    --62939712(+) TAAAGA/GGACAG 1 -- int10--------
    rs1117131111,2
    F--62939715(+) AGAGAC/TAGAGG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs3742121521,2
    C--62939809(+) AGACT-/TGTGATT 1 -- int10--------
    rs1902802711,2
    --62939852(+) TGTCAC/TTGTGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TLN2 (62682725 - 62932725 bp, first 250kb of TLN2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TLN2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672262CNV Deletion23128226
    esv2749767CNV Deletion23290073
    esv2749766CNV Deletion23290073
    esv2054160CNV Deletion18987734
    esv2913CNV Deletion18987735
    esv2749768CNV Deletion23290073
    esv2749769CNV Deletion23290073
    esv1566775CNV Insertion17803354
    nsv1561CNV Insertion18451855
    esv271833CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLN2
    DNA2.0 Custom Variant and Variant Library Synthesis for TLN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607349    OMIM disorders: --


    Find genes that share disorders with TLN2           About GenesLikeMe

    Genetic Association Database (GAD): TLN2
    Human Genome Epidemiology (HuGE) Navigator: TLN2 (1 document)

    Export disorders for TLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLN2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with TLN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the mammalian talin2 gene TLN2. (PubMed id 11527381)1, 2, 3 Monkley S.J.... Critchley D.R. (Biochem. Biophys. Res. Commun. 2001)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. (PubMed id 12422219)1, 2 Di Paolo G.... De Camilli P. (Nature 2002)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. (PubMed id 19109932)1, 9 Xiao F....Wang X.F. (Brain Res. 2009)
    8. Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle. (PubMed id 17183545)1, 9 Senetar M.A....McCann R.O. (Cell Motil. Cytoskeleton 2007)
    9. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. (PubMed id 23266827)1 Manso A.M....Ross R.S. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83660 HGNC: 15447 AceView: TLN2.2 Ensembl:ENSG00000171914 euGenes: HUgn83660
    ECgene: TLN2 Kegg: 83660 H-InvDB: TLN2

    (According to HUGE)
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    HUGE: KIAA0320

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TLN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TLN2 gene:
    Search GeneIP for patents involving TLN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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