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Aliases for TLN2 Gene

Aliases for TLN2 Gene

  • Talin 2 2 3 5
  • KIAA0320 4
  • Talin-2 3
  • ILWEQ 3

External Ids for TLN2 Gene

Previous GeneCards Identifiers for TLN2 Gene

  • GC15P058780
  • GC15P055987
  • GC15P060518
  • GC15P060655
  • GC15P060726
  • GC15P062939
  • GC15P039762
  • GC15P062682

Summaries for TLN2 Gene

Entrez Gene Summary for TLN2 Gene

  • This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLN2 Gene

TLN2 (Talin 2) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Arrhythmogenic right ventricular cardiomyopathy (ARVC). GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is MIR6852.

UniProtKB/Swiss-Prot for TLN2 Gene

  • As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLN2 Gene

Genomics for TLN2 Gene

Regulatory Elements for TLN2 Gene

Enhancers for TLN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F062603 1.4 FANTOM5 Ensembl ENCODE 15.6 +213.5 213476 1.4 TBP ZFP64 SIN3A BRCA1 RAD21 RFX5 GTF3C2 RCOR1 FOS THAP11 TLN2 VPS13C MGC15885 GC15P067902
GH15F062605 1 Ensembl ENCODE 15.8 +216.3 216275 2.4 PKNOX1 JUN SIN3A ZBTB40 BRCA1 RAD21 YY1 RFX5 CTBP1 GATA3 TLN2 MGC15885 GC15P067902
GH15F062389 1.3 FANTOM5 ENCODE 10.3 +0.9 873 3.2 ATF1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF263 MXD4 SMARCB1 TLN2 GC15P067902
GH15F062569 1.2 Ensembl ENCODE 10.8 +179.6 179598 2.1 ATF1 MLX ARID4B ZNF48 YY1 SLC30A9 SP5 MXD4 MIER2 PPARG TLN2 GC15P067902 MGC15885
GH15F062623 0.9 Ensembl ENCODE 11 +234.6 234552 2.2 ZFHX2 SMARCA4 POLR2A SIN3A ZNF140 JUNB IRF1 EGR2 TLN2 LOC101928955 LACTB MGC15885 GC15P067902
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLN2 on UCSC Golden Path with GeneCards custom track

Promoters for TLN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000409215 375 3000 ATF1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF263 MXD4 PPARG

Genomic Location for TLN2 Gene

Chromosome:
15
Start:
62,390,526 bp from pter
End:
62,844,631 bp from pter
Size:
454,106 bases
Orientation:
Plus strand

Genomic View for TLN2 Gene

Genes around TLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLN2 Gene

Proteins for TLN2 Gene

  • Protein details for TLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4G6-TLN2_HUMAN
    Recommended name:
    Talin-2
    Protein Accession:
    Q9Y4G6
    Secondary Accessions:
    • A6NLB8

    Protein attributes for TLN2 Gene

    Size:
    2542 amino acids
    Molecular mass:
    271613 Da
    Quaternary structure:
    • Interacts directly with PIP5K1C.

neXtProt entry for TLN2 Gene

Post-translational modifications for TLN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for TLN2 Gene

Domains & Families for TLN2 Gene

Gene Families for TLN2 Gene

Suggested Antigen Peptide Sequences for TLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4G6

UniProtKB/Swiss-Prot:

TLN2_HUMAN :
  • Contains 1 FERM domain.
Domain:
  • Contains 1 FERM domain.
  • Contains 1 I/LWEQ domain.
genes like me logo Genes that share domains with TLN2: view

Function for TLN2 Gene

Molecular function for TLN2 Gene

UniProtKB/Swiss-Prot Function:
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity).

Gene Ontology (GO) - Molecular Function for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA,NAS 10320934
GO:0005198 structural molecule activity NAS 10320934
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 10320934
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TLN2: view
genes like me logo Genes that share phenotypes with TLN2: view

Animal Models for TLN2 Gene

MGI Knock Outs for TLN2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLN2 Gene

Localization for TLN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLN2 Gene

Cytoplasm. Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses (PubMed:12422219). {ECO:0000269 PubMed:12422219}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLN2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IC 15494027
genes like me logo Genes that share ontologies with TLN2: view

Pathways & Interactions for TLN2 Gene

genes like me logo Genes that share pathways with TLN2: view

Gene Ontology (GO) - Biological Process for TLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007016 cytoskeletal anchoring at plasma membrane IEA --
GO:0007043 cell-cell junction assembly TAS 15494027
GO:0007155 cell adhesion IEA,NAS 11907066
genes like me logo Genes that share ontologies with TLN2: view

No data available for SIGNOR curated interactions for TLN2 Gene

Transcripts for TLN2 Gene

mRNA/cDNA for TLN2 Gene

(14) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b · 54c
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:

Relevant External Links for TLN2 Gene

GeneLoc Exon Structure for
TLN2
ECgene alternative splicing isoforms for
TLN2

Expression for TLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLN2 Gene

This gene is overexpressed in Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLN2 Gene



Protein tissue co-expression partners for TLN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLN2 Gene:

TLN2

SOURCE GeneReport for Unigene cluster for TLN2 Gene:

Hs.569438
genes like me logo Genes that share expression patterns with TLN2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TLN2 Gene

Orthologs for TLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLN2 34 35
  • 99.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TLN2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLN2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLN2 34 35
  • 91.77 (n)
cow
(Bos Taurus)
Mammalia TLN2 34 35
  • 90.78 (n)
mouse
(Mus musculus)
Mammalia Tln2 34 16 35
  • 89.68 (n)
rat
(Rattus norvegicus)
Mammalia Tln2 34
  • 89.64 (n)
chicken
(Gallus gallus)
Aves TLN2 34 35
  • 81.39 (n)
lizard
(Anolis carolinensis)
Reptilia TLN2 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tln2 34
  • 76.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2037 34
zebrafish
(Danio rerio)
Actinopterygii TLN2 (2 of 2) 35
  • 86 (a)
OneToMany
tln2a 34 35
  • 75.63 (n)
zgc63613 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007474 34
  • 55.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta rhea 35 34
  • 54.23 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.11 34
  • 48.24 (n)
tln-1 35
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5889 35
  • 58 (a)
OneToOne
Species where no ortholog for TLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLN2 Gene

ENSEMBL:
Gene Tree for TLN2 (if available)
TreeFam:
Gene Tree for TLN2 (if available)

Paralogs for TLN2 Gene

Paralogs for TLN2 Gene

(1) SIMAP similar genes for TLN2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for TLN2 Gene

genes like me logo Genes that share paralogs with TLN2: view

Variants for TLN2 Gene

Sequence variations from dbSNP and Humsavar for TLN2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10048001 -- 62,504,804(+) AACAG(A/G)AAGTA intron-variant
rs10048006 -- 62,504,872(+) gagag(A/G)gagaC intron-variant
rs10152360 -- 62,562,347(+) TGACA(C/G)CTGGC intron-variant
rs10152548 -- 62,763,459(+) GACTG(A/T)GTCAG intron-variant
rs10152905 -- 62,682,548(+) AGTTA(C/T)CTTAC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TLN2 Gene

Variant ID Type Subtype PubMed ID
nsv94552 CNV insertion 16902084
nsv833032 CNV loss 17160897
nsv1562 CNV insertion 18451855
nsv1561 CNV insertion 18451855
nsv1153645 CNV deletion 26484159
nsv1134457 CNV deletion 24896259
nsv1116080 CNV deletion 24896259
nsv1070702 CNV deletion 25765185
nsv1045036 CNV gain 25217958
nsv1044132 CNV gain 25217958
nsv1035441 CNV gain 25217958
esv3636705 CNV loss 21293372
esv3581742 CNV loss 25503493
esv3415480 CNV insertion 20981092
esv3403298 CNV insertion 20981092
esv3307559 CNV mobile element insertion 20981092
esv2913 CNV loss 18987735
esv2749769 CNV deletion 23290073
esv2749768 CNV deletion 23290073
esv2749767 CNV deletion 23290073
esv2749766 CNV deletion 23290073
esv2672262 CNV deletion 23128226
esv2054160 CNV deletion 18987734
esv1566775 CNV insertion 17803354

Variation tolerance for TLN2 Gene

Residual Variation Intolerance Score: 0.416% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.68; 86.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLN2 Gene

Disorders for TLN2 Gene

Relevant External Links for TLN2

Genetic Association Database (GAD)
TLN2
Human Genome Epidemiology (HuGE) Navigator
TLN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLN2

No disorders were found for TLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLN2 Gene

Publications for TLN2 Gene

  1. Analysis of the mammalian talin2 gene TLN2. (PMID: 11527381) Monkley S.J. … Critchley D.R. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. (PMID: 19109932) Xiao F. … Wang X.F. (Brain Res. 2009) 3 22 64
  5. Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle. (PMID: 17183545) Senetar M.A. … McCann R.O. (Cell Motil. Cytoskeleton 2007) 3 22 64

Products for TLN2 Gene

Sources for TLN2 Gene

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