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Aliases for TLN1 Gene

Aliases for TLN1 Gene

  • Talin 1 2 3
  • TLN 3 4
  • KIAA1027 4
  • Talin-1 3
  • ILWEQ 3

External Ids for TLN1 Gene

Previous Symbols for TLN1 Gene

  • TLN

Summaries for TLN1 Gene

Entrez Gene Summary for TLN1 Gene

  • This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

GeneCards Summary for TLN1 Gene

TLN1 (Talin 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include actin binding and insulin receptor binding. An important paralog of this gene is HIP1.

UniProtKB/Swiss-Prot for TLN1 Gene

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Gene Wiki entry for TLN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLN1 Gene

Genomics for TLN1 Gene

Genomic Location for TLN1 Gene

Start:
35,696,948 bp from pter
End:
35,732,395 bp from pter
Size:
35,448 bases
Orientation:
Minus strand

Genomic View for TLN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLN1 Gene

Proteins for TLN1 Gene

  • Protein details for TLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y490-TLN1_HUMAN
    Recommended name:
    Talin-1
    Protein Accession:
    Q9Y490
    Secondary Accessions:
    • A6NMY0
    • Q86YD0
    • Q9NZQ2
    • Q9UHH8
    • Q9UPX3

    Protein attributes for TLN1 Gene

    Size:
    2541 amino acids
    Molecular mass:
    269767 Da
    Quaternary structure:
    • Binds with high affinity to VCL and with low affinity to integrins. Interacts with APBB1IP; this inhibits VCL binding. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with human cytomegalovirus protein UL135.
    SequenceCaution:
    • Sequence=BAA82979.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TLN1 Gene

neXtProt entry for TLN1 Gene

Proteomics data for TLN1 Gene at MOPED

Post-translational modifications for TLN1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys334, Lys357, Lys428, Lys869, and Lys1541

Other Protein References for TLN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TLN1 Gene

Domains for TLN1 Gene

UniProtKB/Swiss-Prot:

TLN1_HUMAN
Domain:
  • Contains 1 FERM domain.:
    • Q9Y490
  • Contains 1 I/LWEQ domain.:
    • Q9Y490
genes like me logo Genes that share domains with TLN1: view

No data available for Gene Families for TLN1 Gene

Function for TLN1 Gene

Molecular function for TLN1 Gene

UniProtKB/Swiss-Prot Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Gene Ontology (GO) - Molecular Function for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005158 insulin receptor binding IEA --
GO:0005178 integrin binding IPI 12473654
GO:0005200 structural constituent of cytoskeleton NAS 10610730
GO:0005515 protein binding IPI 11279249
genes like me logo Genes that share ontologies with TLN1: view
genes like me logo Genes that share phenotypes with TLN1: view

Animal Models for TLN1 Gene

MGI Knock Outs for TLN1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TLN1 Gene

Localization for TLN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLN1 Gene

Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLN1 Gene COMPARTMENTS Subcellular localization image for TLN1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 4
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TLN1: view

Pathways for TLN1 Gene

genes like me logo Genes that share pathways with TLN1: view

Gene Ontology (GO) - Biological Process for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006928 movement of cell or subcellular component NAS 10610730
GO:0006936 muscle contraction TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0007016 cytoskeletal anchoring at plasma membrane NAS 10610730
genes like me logo Genes that share ontologies with TLN1: view

Transcripts for TLN1 Gene

Unigene Clusters for TLN1 Gene

Talin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLN1 Gene

No ASD Table

Relevant External Links for TLN1 Gene

GeneLoc Exon Structure for
TLN1
ECgene alternative splicing isoforms for
TLN1

Expression for TLN1 Gene

mRNA expression in normal human tissues for TLN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLN1 Gene

This gene is overexpressed in Artery - Tibial (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLN1 Gene

SOURCE GeneReport for Unigene cluster for TLN1 Gene Hs.471014

genes like me logo Genes that share expressions with TLN1: view

Orthologs for TLN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLN1 36
  • 98.99 (n)
  • 99.06 (a)
TLN1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLN1 36
  • 91.85 (n)
  • 98.98 (a)
TLN1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLN1 36
  • 92.56 (n)
  • 99.29 (a)
TLN1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tln1 36
  • 90.73 (n)
  • 98.74 (a)
Tln1 16
Tln1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLN1 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLN1 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tln1 36
  • 90.61 (n)
  • 98.62 (a)
chicken
(Gallus gallus)
Aves TLN1 36
  • 80.37 (n)
  • 89.16 (a)
TLN1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLN1 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18467 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15058 36
zebrafish
(Danio rerio)
Actinopterygii sbcb854 36
tln1 36
  • 75.43 (n)
  • 83.26 (a)
tln1 37
  • 83 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Talin 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea hipr-1 37
  • 18 (a)
ManyToMany
Y71G12B.11b 38
  • 41 (a)
Y71G12B.11a 38
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 37
  • 19 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9312 36
Species with no ortholog for TLN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLN1 Gene

ENSEMBL:
Gene Tree for TLN1 (if available)
TreeFam:
Gene Tree for TLN1 (if available)

Paralogs for TLN1 Gene

Paralogs for TLN1 Gene

Selected SIMAP similar genes for TLN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLN1: view

Variants for TLN1 Gene

Sequence variations from dbSNP and Humsavar for TLN1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs11496 -- 35,697,473(+) CTGGC(C/T)GGAAG utr-variant-3-prime
rs741917 -- 35,707,057(+) GGTTC(C/T)CCATC intron-variant
rs867194 -- 35,705,089(-) CCACA(C/T)TCAAG intron-variant
rs877365 -- 35,713,184(+) GCTCT(C/T)TGCCC intron-variant
rs909304 -- 35,705,007(-) ATTTT(A/C)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLN1 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294
nsv466385 CNV Loss 19166990
nsv6528 CNV Insertion 18451855
nsv819330 CNV Loss 19587683
esv25437 CNV Loss 19812545

Relevant External Links for TLN1 Gene

HapMap Linkage Disequilibrium report
TLN1

Disorders for TLN1 Gene

No disorders were found for TLN1 Gene.

No data available for UniProtKB/Swiss-Prot for TLN1 Gene

Publications for TLN1 Gene

  1. Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. (PMID: 10610730) Ben-Yosef T. … Francomano C.A. (Genomics 1999) 2 3 4 23
  2. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. (PMID: 17597073) Manevich E. … Alon R. (J. Biol. Chem. 2007) 3 23
  3. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. (PMID: 10320340) Luo G. … Horowits R. (Biochemistry 1999) 3 4
  4. Structural basis for amplifying vinculin activation by talin. (PMID: 15070891) Izard T. … Vonrhein C. (J. Biol. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TLN1 Gene

Sources for TLN1 Gene

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