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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLN1 Gene

protein-coding   GIFtS: 63
GCID: GC09M035687

Talin 1


(Previous symbol: TLN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Talin 11 2
TLN1 2 3
ILWEQ2
talin-12
KIAA10273

External Ids:    HGNC: 118451   Entrez Gene: 70942   Ensembl: ENSG000001370767   OMIM: 1867455   UniProtKB: Q9Y4903   

Export aliases for TLN1 gene to outside databases

Previous GC identifers: GC09M036009 GC09M035866


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLN1 Gene:
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts.
The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of
various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface
membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to
other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix
junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
(provided by RefSeq, Feb 2009)

GeneCards Summary for TLN1 Gene: 
TLN1 (talin 1) is a protein-coding gene. Diseases associated with TLN1 include embryonal rhabdomyosarcoma, and rhabdomyosarcoma, and among its related super-pathways are Focal Adhesion and Activation of Chaperones by IRE1alpha. GO annotations related to this gene include actin binding and insulin receptor binding. An important paralog of this gene is TLN2.

UniProtKB/Swiss-Prot: TLN1_HUMAN, Q9Y490
Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular
weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell
contacts (By similarity)

Gene Wiki entry for TLN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLN1 gene promoter:
         AP-2alpha isoform 3   AP-1   STAT5A   Nkx2-5   AP-2alpha isoform 2   c-Ets-1   C/EBPalpha   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p23-p21

TLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLN1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035687:  view genomic region     (about GC identifiers)

Start:
35,696,945 bp from pter      End:
35,732,392 bp from pter
Size:
35,448 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLN1_HUMAN, Q9Y490 (See protein sequence)
Recommended Name: Talin-1  
Size: 2541 amino acids; 269767 Da
Subunit: Binds with high affinity to VCL and with low affinity to integrins. Interacts with APBB1IP; this inhibits
VCL binding. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN.
Interacts with SYNM. Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1
Subcellular location: Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By
similarity). Cytoplasm, cytoskeleton (By similarity). Cell surface (By similarity). Cell junction, focal adhesion
(By similarity). Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions
than fibrillar adhesions (By similarity)
Sequence caution: Sequence=BAA82979.2; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TLN1:
1SYQ (3D)        4DJ9 (3D)    
Secondary accessions: A6NMY0 Q86YD0 Q9NZQ2 Q9UHH8 Q9UPX3

Explore the universe of human proteins at neXtProt for TLN1: NX_Q9Y490

Explore proteomics data for TLN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y490

  • TLN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLN1 Protein Expression
    REFSEQ proteins: NP_006280.3  
    ENSEMBL proteins: 
     ENSP00000316029   ENSP00000442981  
    Reactome Protein details: Q9Y490
    Human Recombinant Protein Products for TLN1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005576extracellular region TAS--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton ----

    TLN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/13 InterPro protein domains (see all 13):
     IPR019748 FERM_central
     IPR006077 Vinculin/catenin
     IPR002558 ILWEQ_dom
     IPR015710 Talin-1
     IPR015224 Talin_cent

    Graphical View of Domain Structure for InterPro Entry Q9Y490

    ProtoNet protein and cluster: Q9Y490

    2 Blocks protein domains:
    IPB000299 Band 4.1 domain
    IPB002558 I/LWEQ domain


    UniProtKB/Swiss-Prot: TLN1_HUMAN, Q9Y490
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 I/LWEQ domain


    TLN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLN1_HUMAN, Q9Y490
    Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular
    weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell
    contacts (By similarity)

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005158insulin receptor binding IEA--
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton NAS10610730
    GO:0005515protein binding IPI11279249
         
    TLN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TLN1:
     Increased focal adhesion (FA)   Weaker migration 

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tln1):
     behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  muscle 

    TLN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TLN1: Tln1tm3Crit Tln1tm1Crit

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLN1 

    miRNA
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    miRTarBase miRNAs that target TLN1:
    hsa-mir-124 (MIRT002693)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLN1
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TLN1 (see all 18):
    hsa-miR-429 hsa-miR-3664-5p hsa-miR-330-5p hsa-miR-503 hsa-miR-3150a-3p hsa-miR-374c hsa-miR-9 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidTLN1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLN1 About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    2Activation of Chaperone Genes by XBP1(S)
    Activation of Chaperones by IRE1alpha0.94
    Unfolded Protein Response0.76
    Activation of Chaperone Genes by XBP1(S)0.94
    3Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin-mediated cell adhesion and migration0.49
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility0.32
    Cytoskeleton remodeling Integrin outside-in signaling0.37
    4Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    5GRB2:SOS provides linkage to MAPK signaling for Intergrins
    GRB2:SOS provides linkage to MAPK signaling for Intergrins 0.76
    p130Cas linkage to MAPK signaling for integrins0.76

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for TLN1
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cytoskeleton remodeling FAK signaling
    Cell adhesion Integrin inside-out signaling

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLN1 (see all 6)
        MAPK Signaling
    RhoA Pathway
    Paxillin Interactions
    Integrin Pathway
    Calpain Protease Regulates Cellular Mechanics

    1 Cell Signaling Technology (CST) Pathway for TLN1
        Cytoskeletal Signaling

    5/6 GeneGo (Thomson Reuters) Pathways for TLN1 (see all 6)
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Inhibitory action of Lipoxins on neutrophil migration
    Cytoskeleton remodeling FAK signaling

    5/9 BioSystems Pathways for TLN1 (see all 9)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Integrins in angiogenesis
    Paxillin-dependent events mediated by a4b1
    Nectin adhesion pathway

    5/20        Reactome Pathways for TLN1 (see all 20)
        Developmental Biology
    Response to elevated platelet cytosolic Ca2+
    GRB2:SOS provides linkage to MAPK signaling for Intergrins
    Platelet degranulation
    Signal Transduction


    2         Kegg Pathways  (Kegg details for TLN1):
        Focal adhesion
    HTLV-I infection


    TLN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/932 Interacting proteins for TLN1 (Q9Y4901, 2, 3 ENSP000003160294) via UniProtKB, MINT, STRING, and/or I2D (see all 932)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB3P051062, 3MINT-1795071 MINT-1795026 MINT-2793444 MINT-1795056 I2D: score=4 
    ERBB2P046262, 3, ENSP000002695714MINT-74792 MINT-74793 MINT-74791 I2D: score=1 STRING: ENSP00000269571
    BCLAF1Q9NYF82, 3MINT-7945693 MINT-7947479 I2D: score=1 
    FUSP356372, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HNRNPH1P319432, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006928cellular component movement NAS10610730
    GO:0006936muscle contraction TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0007016cytoskeletal anchoring at plasma membrane NAS10610730

    TLN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLN1

    Search CenterWatch for drugs/clinical trials and news about TLN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLN1 gene: 
    NM_006289.3  

    Unigene Cluster for TLN1:

    Talin 1
    Hs.471014  [show with all ESTs]
    Unigene Representative Sequence: NM_006289
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314888(uc003zxt.2) ENST00000489255 ENST00000464379 ENST00000466916
    ENST00000465002 ENST00000486788 ENST00000495712 ENST00000378192(uc003zxu.4)
    ENST00000540444
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    Additional mRNA sequence: 

    AB028950.2 AF001392.1 AF078828.1 AF113217.1 AF177198.1 AK001026.1 BC020881.1 BC042923.1 
    Z50170.1 

    24/29 DOTS entries (see all 29):

    DT.92451593  DT.92451583  DT.315829  DT.100825199  DT.91770045  DT.95130790  DT.121191152  DT.91655792 
    DT.97860687  DT.121191075  DT.100825193  DT.95149204  DT.310205  DT.95149200  DT.91732564  DT.95149192 
    DT.99977584  DT.100825197  DT.100825201  DT.100825202  DT.121191034  DT.121191135  DT.121191161  DT.91738345 

    24/835 AceView cDNA sequences (see all 835):

    BF725093 BU149396 BM470907 NM_006289 BU168104 BQ894675 BM008318 BG997655 
    BG747780 BQ417082 BQ946645 BE910015 BU185977 BQ218538 CN483804 BG419823 
    T27372 BI063682 BU145903 AW451582 BU172153 CD622337 BU164022 BG768215 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLN1 expression in normal human tissues (normalized intensities)      TLN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCAATAAA
    TLN1 Expression
    About this image


    TLN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             mesenchyme   
     
     Bone (Muscoskeletal System)
             skeleton   
     
     Mesoderm (Gastrulation Derivatives)
             mesenchyme   
     
     Cartilage (Muscoskeletal System)
             skeleton   
     
     Heart (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    See TLN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLN1

    SOURCE GeneReport for Unigene cluster: Hs.471014
        SABiosciences Expression via Pathway-Focused PCR Arrays including TLN1: 
              Adherens Junctions in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TLN1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tln11 , 5 talin 11, 5 90.73(n)1
    98.74(a)1
      4 (23.05 cM)5
    218941  NM_011602.51  NP_035732.21 
     435315195 
    chicken
    (Gallus gallus)
    Aves TLN11 talin 1 80.37(n)
    89.16(a)
      395194  NM_204523.1  NP_989854.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLN16
    --
    Uncharacterized protein
    88(a)
    73(a)
    1 ↔ 1
    possible ortholog
    GL343746.1(7339-64060)
    GL343847.1(34518-39972)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.184672 Xenopus laevis transcribed sequence with strong similarity more 87.15(n)    BI347878.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb8542 sbcb854 77.8(n)   378871  CK028724.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Talin3 cytoskeletal anchoring actin binding 46(a)   66D6   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G12B.11b3   -- 41(a)
    (best of 2)
      I(1721598-1732876)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SLA26
    Transmembrane actin-binding protein involved in me...
    17(a)
    1 → many
    XIV(188051-190957)


    ENSEMBL Gene Tree for TLN1 (if available)
    TreeFam Gene Tree for TLN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLN1 gene
    TLN22  HIP12  HIP1R2  MESDC12  
    1 SIMAP similar gene for TLN1 using alignment to 2 protein entries:     TLN1_HUMAN (see all proteins):
    TLN2

    TLN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/930 SNPs in TLN1 are shown (see all 930)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1482643591,2
    --35697000(+) ATTTGC/TTGACA 1 -- ds50010--------
    rs18853741,2
    C,F,O,A,H--35697081(+) AGCAGA/CAGAAC 1 -- ds500129Minor allele frequency- C:0.09NS EA NA WA CSA 3581
    rs1413736501,2
    --35697091(+) CGACAC/TTTTGT 1 -- ds50010--------
    rs1503448941,2
    --35697277(+) CCCCAC/GTGTCT 1 -- ds50010--------
    rs1380614801,2
    --35697362(+) GGAGCA/CTGACC 1 -- ut310--------
    rs22957931,2
    C,H--35697436(+) AAAACG/AGTGAA 1 -- ut31 ese32Minor allele frequency- A:0.01EA NS 1616
    rs559052511,2
    C--35697453(+) TGATGA/GGGCTG 1 -- ut310--------
    rs114961,2
    C,F,A,H--35697470(+) CTGGCT/CGGAAG 1 -- ut31 ese315Minor allele frequency- C:0.06MN NA WA CSA EA 562
    rs115419111,2
    --35697585(+) CTTGGA/GGGGCC 1 -- ut310--------
    rs1905024671,2
    --35697640(+) TACTGC/TGGGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TLN1 (35696945 - 35732392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TLN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6528CNV Insertion18451855
    esv25437CNV Loss19812545
    nsv819330CNV Loss19587683
    nsv466385CNV Loss19166990
    dgv8168n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186745    OMIM disorders: --

    4 diseases for TLN1:    About MalaCards
    embryonal rhabdomyosarcoma    rhabdomyosarcoma    dilated cardiomyopathy    psoriasis


    TLN1 for disorders           About GeneDecksing


    Export disorders for TLN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLN1 gene, integrated from 9 sources (see all 125):
    (articles sorted by number of sources associating them with TLN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. (PubMed id 10610730)1, 2, 3, 9 Ben-Yosef T. and Francomano C.A. (1999)
    2. Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin. (PubMed id 18342854)1, 2 Sun N.... Robson R.M. (2008)
    3. Structural basis for amplifying vinculin activation by talin. (PubMed id 15070891)1, 2 Izard T. and Vonrhein C. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. (PubMed id 12422220)1, 2 Ling K.... Anderson R.A. (2002)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    8. Molecular interactions of N-RAP, a nebulin-related protein of striated muscle myotendon junctions and intercalated disks. (PubMed id 10320340)1, 2 Luo G.... Horowits R. (1999)
    9. Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p. (PubMed id 7635475)1, 3 Gilmore A.P....Critchley D.R. (1995)
    10. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. (PubMed id 17597073)1, 9 Manevich E....Alon R. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7094 HGNC: 11845 AceView: TLN1 Ensembl:ENSG00000137076 euGenes: HUgn7094
    ECgene: TLN1 Kegg: 7094 H-InvDB: TLN1

    (According to HUGE)
    About This Section
    HUGE: KIAA1027

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TLN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLN1 gene:
    Search GeneIP for patents involving TLN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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