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Aliases for TLN1 Gene

Aliases for TLN1 Gene

  • Talin 1 2 3 5
  • TLN 3 4
  • KIAA1027 4
  • Talin-1 3
  • ILWEQ 3

External Ids for TLN1 Gene

Previous HGNC Symbols for TLN1 Gene

  • TLN

Previous GeneCards Identifiers for TLN1 Gene

  • GC09M036009
  • GC09M035866

Summaries for TLN1 Gene

Entrez Gene Summary for TLN1 Gene

  • This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

GeneCards Summary for TLN1 Gene

TLN1 (Talin 1) is a Protein Coding gene. Diseases associated with TLN1 include Ovarian Serous Carcinoma. Among its related pathways are RET signaling and HTLV-I infection. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TLN2.

UniProtKB/Swiss-Prot for TLN1 Gene

  • Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Gene Wiki entry for TLN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLN1 Gene

Genomics for TLN1 Gene

Regulatory Elements for TLN1 Gene

Enhancers for TLN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F035679 0.6 Ensembl ENCODE 21.5 +46.3 46278 12.8 PKNOX1 ARID4B SIN3A GLIS2 ELK1 FOS ZNF263 SP3 SMARCB1 MBD2 TPM2 GBA2 TMEM8B TLN1 NPR2 CCDC107 SIT1 CREB3 MIR6852 RGP1
GH09F035726 0.9 FANTOM5 ENCODE 11.8 +2.0 1981 8.6 MLX CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TMEM8B GBA2 TPM2 RGP1 TLN1 ARHGEF39 RN7SL22P CCDC107 ENSG00000228843 MSMP
GH09F035694 0.2 ENCODE 11.1 +36.3 36309 2.6 CTCF ARID4B RAD21 ZBTB48 POLR2A ZNF143 SMC3 FOS THAP11 TRIM22 TPM2 ARHGEF39 RN7SL22P CCDC107 SIT1 CA9 CREB3 TLN1 MIR6852 GBA2
GH09F035616 0.4 ENCODE 10.9 +113.1 113141 6.4 HDGF ATF1 PKNOX1 WRNIP1 ZBTB40 ETS1 RFX5 EGR1 SCRT2 ZNF143 CCDC107 RN7SL22P ARHGEF39 SIT1 CA9 FAM166B TLN1 CREB3 MIR6852 GBA2
GH09F035825 1.3 Ensembl ENCODE 10.9 -94.1 -94085 1.0 HDGF CTCF SUZ12 IRF3 RAD21 ZNF143 SMC3 ZBTB20 MIXL1 STAT1 ENSG00000227388 NPR2 ENSG00000228843 MSMP GBA2 RGP1 CREB3 MIR6852 TLN1 OR13J1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TLN1 on UCSC Golden Path with GeneCards custom track

Promoters for TLN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302867 495 3401 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 YY1

Genomic Location for TLN1 Gene

Chromosome:
9
Start:
35,696,948 bp from pter
End:
35,732,395 bp from pter
Size:
35,448 bases
Orientation:
Minus strand

Genomic View for TLN1 Gene

Genes around TLN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLN1 Gene

Proteins for TLN1 Gene

  • Protein details for TLN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y490-TLN1_HUMAN
    Recommended name:
    Talin-1
    Protein Accession:
    Q9Y490
    Secondary Accessions:
    • A6NMY0
    • Q86YD0
    • Q9NZQ2
    • Q9UHH8
    • Q9UPX3

    Protein attributes for TLN1 Gene

    Size:
    2541 amino acids
    Molecular mass:
    269767 Da
    Quaternary structure:
    • Binds with high affinity to VCL and with low affinity to integrins. Interacts with APBB1IP; this inhibits VCL binding. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with human cytomegalovirus protein UL135.
    • Binds with high affinity to VCL and with low affinity to integrins. Interacts with APBB1IP; this inhibits VCL binding. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. Interacts with ITGB1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with human cytomegalovirus protein UL135.
    SequenceCaution:
    • Sequence=BAA82979.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TLN1 Gene

neXtProt entry for TLN1 Gene

Post-translational modifications for TLN1 Gene

  • Ubiquitination at Lys 334, Lys 357, Lys 428, and Lys 869
  • Modification sites at PhosphoSitePlus

Other Protein References for TLN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLN1 (Talin-1)

No data available for DME Specific Peptides for TLN1 Gene

Domains & Families for TLN1 Gene

Gene Families for TLN1 Gene

Suggested Antigen Peptide Sequences for TLN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y490

UniProtKB/Swiss-Prot:

TLN1_HUMAN :
  • Contains 1 FERM domain.
Domain:
  • Contains 1 FERM domain.
  • Contains 1 I/LWEQ domain.
genes like me logo Genes that share domains with TLN1: view

Function for TLN1 Gene

Molecular function for TLN1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Gene Ontology (GO) - Molecular Function for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005178 integrin binding IPI 12473654
GO:0005200 structural constituent of cytoskeleton NAS 10610730
GO:0005515 protein binding IPI 11279249
GO:0017166 vinculin binding IPI 15070891
genes like me logo Genes that share ontologies with TLN1: view
genes like me logo Genes that share phenotypes with TLN1: view

Animal Models for TLN1 Gene

MGI Knock Outs for TLN1:

Animal Model Products

miRNA for TLN1 Gene

miRTarBase miRNAs that target TLN1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLN1 Gene

Localization for TLN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLN1 Gene

Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface. Cell junction, focal adhesion. Note=Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLN1 Gene COMPARTMENTS Subcellular localization image for TLN1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TLN1: view

Pathways & Interactions for TLN1 Gene

SuperPathways for TLN1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Integrin alphaIIb beta3 signaling
3 Response to elevated platelet cytosolic Ca2+
4 Focal Adhesion
5 Unfolded Protein Response (UPR)
genes like me logo Genes that share pathways with TLN1: view

SIGNOR curated interactions for TLN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TLN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006928 movement of cell or subcellular component NAS 10610730
GO:0006936 muscle contraction TAS --
GO:0007016 cytoskeletal anchoring at plasma membrane NAS 10610730
GO:0007043 cell-cell junction assembly TAS 15494027
genes like me logo Genes that share ontologies with TLN1: view

Transcripts for TLN1 Gene

Unigene Clusters for TLN1 Gene

Talin 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLN1 Gene

No ASD Table

Relevant External Links for TLN1 Gene

GeneLoc Exon Structure for
TLN1
ECgene alternative splicing isoforms for
TLN1

Expression for TLN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLN1 Gene

mRNA differential expression in normal tissues according to GTEx for TLN1 Gene

This gene is overexpressed in Artery - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for TLN1 Gene

This gene is overexpressed in Platelet (17.9) and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLN1 Gene



Protein tissue co-expression partners for TLN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLN1 Gene:

TLN1

SOURCE GeneReport for Unigene cluster for TLN1 Gene:

Hs.471014
genes like me logo Genes that share expression patterns with TLN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TLN1 Gene

Orthologs for TLN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLN1 34 35
  • 98.99 (n)
oppossum
(Monodelphis domestica)
Mammalia TLN1 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLN1 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLN1 34 35
  • 92.56 (n)
cow
(Bos Taurus)
Mammalia TLN1 34 35
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Tln1 34 16 35
  • 90.73 (n)
rat
(Rattus norvegicus)
Mammalia Tln1 34
  • 90.61 (n)
chicken
(Gallus gallus)
Aves TLN1 34 35
  • 80.37 (n)
lizard
(Anolis carolinensis)
Reptilia TLN1 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15058 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.18467 34
zebrafish
(Danio rerio)
Actinopterygii tln1 34 35
  • 75.43 (n)
sbcb854 34
fruit fly
(Drosophila melanogaster)
Insecta Talin 36
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.11b 36
  • 41 (a)
Y71G12B.11a 36
  • 37 (a)
hipr-1 35
  • 18 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 35
  • 19 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9312 34
Species where no ortholog for TLN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLN1 Gene

ENSEMBL:
Gene Tree for TLN1 (if available)
TreeFam:
Gene Tree for TLN1 (if available)

Paralogs for TLN1 Gene

Paralogs for TLN1 Gene

(1) SIMAP similar genes for TLN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLN1: view

Variants for TLN1 Gene

Sequence variations from dbSNP and Humsavar for TLN1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1074915 -- 35,709,562(+) CAAGT(A/G)ACTGG intron-variant
rs10814270 -- 35,704,153(+) ACCTT(C/T)GCAGT reference, synonymous-codon
rs10814272 -- 35,715,914(+) ATAGC(C/T)AGGGG intron-variant
rs10814273 -- 35,723,237(+) GCTGG(G/T)ATTAC intron-variant
rs10972563 -- 35,710,379(+) AATCA(A/G)AACTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TLN1 Gene

Variant ID Type Subtype PubMed ID
esv25437 CNV loss 19812545
nsv1125318 OTHER inversion 24896259
nsv466385 CNV loss 19166990
nsv614166 CNV loss 21841781
nsv6528 CNV insertion 18451855
nsv819330 CNV loss 19587683

Variation tolerance for TLN1 Gene

Residual Variation Intolerance Score: 0.301% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.66; 82.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLN1 Gene

Human Gene Mutation Database (HGMD)
TLN1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLN1 Gene

Disorders for TLN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLN1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian serous carcinoma
  • ovarian serous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search TLN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLN1
genes like me logo Genes that share disorders with TLN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLN1 Gene

Publications for TLN1 Gene

  1. Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. (PMID: 10610730) Ben-Yosef T. … Francomano C.A. (Genomics 1999) 2 3 4 22 64
  2. ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. (PMID: 19608030) Moulik M. … Towbin J.A. (J. Am. Coll. Cardiol. 2009) 3 22 64
  3. Identification of a repeated domain within mammalian alpha-synemin that interacts directly with talin. (PMID: 18342854) Sun N. … Robson R.M. (Exp. Cell Res. 2008) 3 4 64
  4. Talin 1 and paxillin facilitate distinct steps in rapid VLA-4-mediated adhesion strengthening to vascular cell adhesion molecule 1. (PMID: 17597073) Manevich E. … Alon R. (J. Biol. Chem. 2007) 3 22 64
  5. Structural basis for amplifying vinculin activation by talin. (PMID: 15070891) Izard T. … Vonrhein C. (J. Biol. Chem. 2004) 3 4 64

Products for TLN1 Gene

Sources for TLN1 Gene

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