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Aliases for TLL2 Gene

Aliases for TLL2 Gene

  • Tolloid-Like 2 2 3
  • KIAA0932 4 6
  • EC 64
  • EC 3.4.24.- 4
  • EC 3.4.24 64

External Ids for TLL2 Gene

Summaries for TLL2 Gene

Entrez Gene Summary for TLL2 Gene

  • This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]

GeneCards Summary for TLL2 Gene

TLL2 (Tolloid-Like 2) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is TLL1.

UniProtKB/Swiss-Prot for TLL2 Gene

  • Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis

Gene Wiki entry for TLL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLL2 Gene

Genomics for TLL2 Gene

Genomic Location for TLL2 Gene

96,364,606 bp from pter
96,513,926 bp from pter
149,321 bases
Minus strand

Genomic View for TLL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLL2 Gene

Regulatory Elements for TLL2 Gene

Proteins for TLL2 Gene

  • Protein details for TLL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tolloid-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NDK0
    • Q2M1H1
    • Q6PJN5
    • Q9UQ00

    Protein attributes for TLL2 Gene

    1015 amino acids
    Molecular mass:
    113557 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    • Sequence=BAA76776.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TLL2 Gene

Proteomics data for TLL2 Gene at MOPED

Post-translational modifications for TLL2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn171, Thr327, Asn361, Asn392, Asn628, and Asn805

Other Protein References for TLL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TLL2 Gene


  • Contains 5 CUB domains.:
    • Q9Y6L7
  • Contains 2 EGF-like domains.:
    • Q9Y6L7
  • Belongs to the peptidase M12A family.:
    • Q9Y6L7
genes like me logo Genes that share domains with TLL2: view

No data available for Gene Families for TLL2 Gene

Function for TLL2 Gene

Molecular function for TLL2 Gene

GENATLAS Biochemistry: tolloid-like gene 2
UniProtKB/Swiss-Prot Function: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis

Enzyme Numbers (IUBMB) for TLL2 Gene

Gene Ontology (GO) - Molecular Function for TLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TLL2: view

Phenotypes for TLL2 Gene

genes like me logo Genes that share phenotypes with TLL2: view

Animal Models for TLL2 Gene

MGI Knock Outs for TLL2:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TLL2 Gene

Localization for TLL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLL2 Gene


Subcellular locations from

Jensen Localization Image for TLL2 Gene COMPARTMENTS Subcellular localization image for TLL2 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with TLL2: view

Pathways for TLL2 Gene

genes like me logo Genes that share pathways with TLL2: view

Interacting Proteins for TLL2 Gene

Gene Ontology (GO) - Biological Process for TLL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007275 multicellular organismal development IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030154 cell differentiation IEA --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with TLL2: view

Compounds for TLL2 Gene

(1) Drugbank Compounds for TLL2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
genes like me logo Genes that share compounds with TLL2: view

Transcripts for TLL2 Gene

mRNA/cDNA for TLL2 Gene

Unigene Clusters for TLL2 Gene

Tolloid-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLL2 Gene

No ASD Table

Relevant External Links for TLL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLL2 Gene

mRNA expression in normal human tissues for TLL2 Gene

mRNA differential expression in normal tissues according to GTEx for TLL2 Gene

This gene is overexpressed in Heart - Left Ventricle (5.6) and Brain - Spinal cord (cervical c-1) (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLL2 Gene

SOURCE GeneReport for Unigene cluster for TLL2 Gene Hs.154296

genes like me logo Genes that share expressions with TLL2: view

Orthologs for TLL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLL2 36
  • 98.22 (n)
  • 97.88 (a)
TLL2 37
  • 99 (a)
(Bos Taurus)
Mammalia TLL2 36
  • 90.08 (n)
  • 92.12 (a)
TLL2 37
  • 95 (a)
(Canis familiaris)
Mammalia TLL2 36
  • 89.56 (n)
  • 91.32 (a)
TLL2 37
  • 95 (a)
(Mus musculus)
Mammalia Tll2 36
  • 86.3 (n)
  • 90.51 (a)
Tll2 16
Tll2 37
  • 90 (a)
(Monodelphis domestica)
Mammalia TLL2 37
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia TLL2 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Tll2 36
  • 85.95 (n)
  • 89.73 (a)
(Gallus gallus)
Aves TLL2 37
  • 74 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.36 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16546 36
(Danio rerio)
Actinopterygii CR352286.1 37
  • 12 (a)
fruit fly
(Drosophila melanogaster)
Insecta tld 37
  • 40 (a)
tok 37
  • 34 (a)
tok 38
  • 53 (a)
tld 38
  • 45 (a)
(Caenorhabditis elegans)
Secernentea nas-39 37
  • 42 (a)
T04G9.2 38
  • 40 (a)
toh-2 38
  • 30 (a)
Y95B8A.1 38
  • 37 (a)
C07D10.4 38
  • 35 (a)
F38E9.2 38
  • 40 (a)
F09E8.6 38
  • 37 (a)
C34D4.9 38
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
Species with no ortholog for TLL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLL2 Gene

Gene Tree for TLL2 (if available)
Gene Tree for TLL2 (if available)

Paralogs for TLL2 Gene

Paralogs for TLL2 Gene

Selected SIMAP similar genes for TLL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TLL2: view

Variants for TLL2 Gene

Sequence variations from dbSNP and Humsavar for TLL2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs243 -- 96,480,625(-) TGTTC(C/T)TCTGC intron-variant
rs818 -- 96,480,630(-) CCTGC(C/T)GTTCC intron-variant
rs730179 -- 96,411,568(+) TACCT(A/G)TATGA intron-variant
rs730596 -- 96,412,257(-) TACCT(C/T)ACTAA intron-variant
rs734566 -- 96,495,557(-) ACACC(A/G)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLL2 Gene

Variant ID Type Subtype PubMed ID
nsv831949 CNV Gain 17160897
nsv831950 CNV Gain 17160897
esv2665154 CNV Deletion 23128226
nsv509362 CNV Insertion 20534489
esv2622954 CNV Insertion 19546169
esv1243485 CNV Insertion 17803354
nsv513012 CNV Insertion 21212237

Relevant External Links for TLL2 Gene

HapMap Linkage Disequilibrium report

Disorders for TLL2 Gene

Relevant External Links for TLL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TLL2: view

No data available for UniProtKB/Swiss-Prot for TLL2 Gene

Publications for TLL2 Gene

  1. Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases. (PMID: 18824173) Mac Sweeney A. … Gerhartz B. (J. Mol. Biol. 2008) 3 23
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  3. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. (PMID: 10479448) Scott I.C. … Greenspan D.S. (Dev. Biol. 1999) 3 4
  4. Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19. (PMID: 10516436) Scott I.C. … Greenspan D.S. (Cytogenet. Cell Genet. 1999) 2 3
  5. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. (PMID: 11313359) Uzel M.I. … Trackman P.C. (J. Biol. Chem. 2001) 3 4

Products for TLL2 Gene

Sources for TLL2 Gene

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