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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLL2 Gene

protein-coding   GIFtS: 58
GCID: GC10M098114

Tolloid-Like 2

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tolloid-Like 21 2
KIAA09323 5
Tolloid-Like Protein 22
EC 3.4.24.-3
EC 3.4.248
EC 3.4.24.198

External Ids:    HGNC: 118441   Entrez Gene: 70932   Ensembl: ENSG000000955877   OMIM: 6067435   UniProtKB: Q9Y6L73   

Export aliases for TLL2 gene to outside databases

Previous GC identifers: GC10M097019 GC10M097358 GC10M098255 GC10M097788 GC10M091752


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLL2 Gene:
This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin
family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or
chordin. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLL2 Gene: 
TLL2 (tolloid-like 2) is a protein-coding gene. Diseases associated with TLL2 include alzheimer's disease, and among its related super-pathways are Collagen formation. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is CUBN.

UniProtKB/Swiss-Prot: TLL2_HUMAN, Q9Y6L7
Function: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development.
Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis

Gene Wiki entry for TLL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLL2 gene promoter:
         TBP   AML1a   YY1   PPAR-gamma1   FOXO4   TFIID   FOXJ2 (long isoform)   c-Myb   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23-q24

TLL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLL2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098114:  view genomic region     (about GC identifiers)

Start:
98,124,363 bp from pter      End:
98,273,683 bp from pter
Size:
149,321 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLL2_HUMAN, Q9Y6L7 (See protein sequence)
Recommended Name: Tolloid-like protein 2 precursor  
Size: 1015 amino acids; 113557 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subcellular location: Secreted (Probable)
Sequence caution: Sequence=BAA76776.2; Type=Erroneous initiation;
Secondary accessions: A6NDK0 Q2M1H1 Q6PJN5 Q9UQ00

Explore the universe of human proteins at neXtProt for TLL2: NX_Q9Y6L7

Explore proteomics data for TLL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6L7

  • 4/32 DME Specific Peptides for TLL2 (Q9Y6L7) (see all 32)
     YLEVRDG  WEKHTCV  KDNGGCQ  CAYDYLE 

    TLL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLL2 Protein Expression
    REFSEQ proteins: NP_036597.1  
    ENSEMBL proteins: 
     ENSP00000350630  
    Reactome Protein details: Q9Y6L7
    Human Recombinant Protein Products for TLL2: 
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    Novus Biologicals TLL2 Protein
    Novus Biologicals TLL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLL2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    TLL2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for TLL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR000859 CUB_dom
     IPR015446 BMP_1/tolloid-like
     IPR024079 MetalloPept_cat_dom
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6L7

    ProtoNet protein and cluster: Q9Y6L7

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB001506 Astacin family signature


    UniProtKB/Swiss-Prot: TLL2_HUMAN, Q9Y6L7
    Similarity: Belongs to the peptidase M12A family
    Similarity: Contains 5 CUB domains
    Similarity: Contains 2 EGF-like domains


    TLL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLL2_HUMAN, Q9Y6L7
    Function: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development.
    Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis

         Genatlas biochemistry entry for TLL2:
    tolloid-like gene 2

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.192 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    TLL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tll2):
     muscle  no phenotypic analysis 

    TLL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tll2tm1.1Sjl for TLL2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLL2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLL2 
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    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate TLL2 (see all 44):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-30d hsa-miR-507 hsa-miR-30a hsa-miR-532-5p hsa-miR-1183
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.74
    Assembly of collagen fibrils and other multimeric structures0.65
    Collagen formation0.74
    Extracellular matrix organization0.39
    2Crosslinking of collagen fibrils
    Crosslinking of collagen fibrils
    3Anchoring fibril formation
    Anchoring fibril formation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for TLL2 (see all 6)
        Anchoring fibril formation
    Extracellular matrix organization
    Collagen biosynthesis and modifying enzymes
    Assembly of collagen fibrils and other multimeric structures
    Crosslinking of collagen fibrils



    TLL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLL2

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--
    GO:0030198extracellular matrix organization TAS--

    TLL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLL2

    1 DrugBank Compound for TLL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carbobenzoxy-Pro-Lys-Phe-Y(Po2)-Ala-Pro-Ome-- --target--17139284 17016423 10592235

    Search CenterWatch for drugs/clinical trials and news about TLL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLL2 gene: 
    NM_012465.3  

    Unigene Cluster for TLL2:

    Tolloid-like 2
    Hs.154296  [show with all ESTs]
    Unigene Representative Sequence: NM_012465
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357947(uc001kml.2) ENST00000506028 ENST00000469598(uc009xvf.2)


    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate TLL2 (see all 44):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-30d hsa-miR-507 hsa-miR-30a hsa-miR-532-5p hsa-miR-1183
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLL2
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    Additional mRNA sequence: 

    AB023149.2 AK026106.1 BC013871.2 BC030548.1 BC112341.1 BC112366.1 BC113577.1 

    3 DOTS entries:

    DT.70105453  DT.100742172  DT.91811968 

    24/26 AceView cDNA sequences (see all 26):

    AK026106 BQ086177 BC030548 AB023149 AI381881 AI791959 NM_012465 BC013871 
    CR606485 BX280499 BI517607 BG323677 AI652547 AA582404 AW452288 BX369052 
    BF057747 AI199925 BE745114 AF059516 AL530453 BI518327 AI380252 AI889073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGATGTC
    TLL2 Expression
    About this image


    See TLL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLL2

    SOURCE GeneReport for Unigene cluster: Hs.154296
        SABiosciences Custom PCR Arrays for TLL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TLL2 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tll21 , 5 tolloid-like 21, 5 86.3(n)1
    90.51(a)1
      19 (34.39 cM)5
    240871  NM_011904.31  NP_036034.11 
     410839815 
    chicken
    (Gallus gallus)
    Aves TLL21 tolloid-like 2 77.74(n)
    83.95(a)
      423754  XM_003641539.1  XP_003641587.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.362 X.laevis mRNA for xolloid 79(n)    Y09661.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tok3 procollagen C-endopeptidase 53(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for TLL2 (if available)
    TreeFam Gene Tree for TLL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLL2 gene
    CUBN2  CDCP22  PCOLCE2  BMP12  PCOLCE22  NETO22  MFRP2  NETO12  
    TLL12  
    3 SIMAP similar genes for TLL2 using alignment to 1 protein entry:     TLL2_HUMAN:
    BMP1    TLL1    NRP2

    TLL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3140 SNPs in TLL2 are shown (see all 3140)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559757481,2
    C--91788044(+) AAAAA-/A/A   
       A
    /AAA
    CAAAA
    2 -- int1 cds11NA 2
    rs571538961,2
    C--91889360(+) AAAAA-/A/AA  
            
    TACAA
    1 -- int11NA 2
    rs70911251,2
    C,F,H--98124038(+) GGCGAC/TGGGAG 1 -- int118Minor allele frequency- T:0.08NS EA NA WA CSA 789
    rs1861136851,2
    --98124086(+) GGTTTC/TGGCAG 1 -- int10--------
    rs1480211911,2
    --98124091(+) CGGCAG/TCAGAC 1 -- int10--------
    rs751780331,2
    C--98124094(+) CAGCAA/GACATC 1 -- int10--------
    rs1897921631,2
    C--98124315(+) GCACTA/TAAAGG 1 -- int10--------
    rs70739041,2
    C,F,H--98124394(+) CATCCT/GTTCTA 1 -- ut31 ese317Minor allele frequency- G:0.03NS EA NA WA CSA 934
    rs1501570811,2
    C--98124401(+) TCTAGC/GTAGAG 1 -- ut310--------
    rs769411621,2
    C,F--98124680(+) ATCAAT/CAGAAA 1 -- ut311Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for TLL2 (98124363 - 98273683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TLL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665154CNV Deletion23128226
    nsv513012CNV Insertion21212237
    esv1243485CNV Insertion17803354
    esv2622954CNV Insertion19546169
    nsv509362CNV Insertion20534489
    nsv831949CNV Gain17160897
    nsv831950CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606743    OMIM disorders: --

    2 diseases for TLL2:    About MalaCards
    alzheimer's disease    


    TLL2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TLL2
    Human Genome Epidemiology (HuGE) Navigator: TLL2 (1 document)

    Export disorders for TLL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLL2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with TLL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (2008)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. (PubMed id 11313359)1, 2 Uzel M.I.... Trackman P.C. (2001)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    7. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. (PubMed id 10479448)1, 2 Scott I.C....Greenspan D.S. (1999)
    8. Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19. (PubMed id 10516436)1, 3 Scott I.C....Greenspan D.S. (1999)
    9. Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases. (PubMed id 18824173)1, 9 Mac Sweeney A....Gerhartz B. (2008)
    10. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7093 HGNC: 11844 AceView: TLL2 Ensembl:ENSG00000095587 euGenes: HUgn7093
    ECgene: TLL2 H-InvDB: TLL2

    (According to HUGE)
    About This Section
    HUGE: KIAA0932

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLL2 gene:
    Search GeneIP for patents involving TLL2

    GeneCards and IP:
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