TLL2 Gene

Aliases
for TLL2 gene

Previous GC identifers: GC10M097019 GC10M097358 GC10M098255 GC10M097788 GC10M091752

Summaries
for TLL2 gene

Genomic Views
for TLL2 gene

RefSeq DNA sequence:

NC_000010.10  NC_018921.1  NT_030059.13  

SwitchGear Promoter luciferase reporter plasmid: TLL2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLL2

TLL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098114:  view genomic region     (about GC identifiers)

Proteins
for TLL2 gene

Explore the universe of human proteins at neXtProt for TLL2: NX_Q9Y6L7

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TLL2 OriGene Custom Protein Services for TLL2
	GenScript Custom Purified and Recombinant Proteins Services for TLL2
	Novus Biologicals TLL2 Protein Novus Biologicals TLL2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TLL2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TLL2
	GenScript Custom Superior Antibodies Services for TLL2
	Novus Biologicals TLL2 Antibody
	Search for Antibodies for TLL2 at Abcam
	Uscn Antibodies for TLL2
	Search ThermoFisher Antibodies for TLL2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TLL2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TLL2

Protein Domains /
Families
for TLL2 gene

ProtoNet protein and cluster: Q9Y6L7

Function
for TLL2 gene

miRNA Products:		OriGene 3'-UTR Clone: TLL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLL2
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate TLL2 (see all 44):
		hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-30d hsa-miR-507 hsa-miR-30a hsa-miR-532-5p hsa-miR-1183
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLL2 (see all 4) OriGene shRNA RFP: TLL2 OriGene siRNA: TLL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLL2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TLL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLL2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TLL2 (NM_012465)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TLL2
		Search LifeMap BioReagents cell lines for TLL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLL2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Tll2)

Pathways & Interactions
for TLL2 gene

	Super-pathway	contained gene-specific pathways
1	Collagen formation	Collagen formation 1.00 Assembly of collagen fibrils and other multimeric structures 0.65 Collagen biosynthesis and modifying enzymes 0.74 Extracellular matrix organization 0.54
2	Crosslinking of collagen fibrils	Crosslinking of collagen fibrils 1.00
3	Gelatin degradation by MMP19	Anchoring fibril formation 0.39

5/6        Reactome Pathways for TLL2

	Anchoring fibril formation
	Extracellular matrix organization
	Collagen biosynthesis and modifying enzymes
	Assembly of collagen fibrils and other multimeric structures
	Crosslinking of collagen fibrils

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for TLL2 gene

Transcripts
for TLL2 gene

Expression
for TLL2 gene

TLL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGATGTC

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Cardiomyocyte-like cells (Spontaneous differen...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLL2

Orthologs
for TLL2 gene

Paralogs
for TLL2 gene

Paralogs for TLL2 gene

CUBN²  CDCP2²  PCOLCE²  BMP1²  PCOLCE2²  NETO2²  MFRP²  NETO1²  

TLL1²  

3 SIMAP similar genes for TLL2 using alignment to 1 protein entry:     TLL2_HUMAN:

BMP1    TLL1    NRP2

TLL2 for paralogs           About GeneDecksing

Genomic Variants
for TLL2 gene

10/2637 NCBI SNPs in TLL2 are shown (see all 2637)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs70911251,2	C,F,H,	--	98124038(+)	GGCGAC/TGGGAG	1	--	int1		18		NS EA NA WA CSA	789
rs1861136851,2		--	98124086(+)	GGTTTC/TGGCAG	1	--	int1		0	--	--	--	--
rs1480211911,2		--	98124091(+)	CGGCAG/TCAGAC	1	--	int1		0	--	--	--	--
rs751780331,2	C,	--	98124094(+)	CAGCAA/GACATC	1	--	int1		0	--	--	--	--
rs1897921631,2		--	98124315(+)	GCACTA/TAAAGG	1	--	int1		0	--	--	--	--
rs70739041,2	C,F,H,	--	98124394(+)	CATCCT/GTTCTA	1	--	ut31 ese3		17		NS EA NA WA CSA	934
rs1501570811,2		--	98124401(+)	TCTAGC/GTAGAG	1	--	ut31		0	--	--	--	--
rs769411621,2		--	98124680(+)	ATCAAT/CAGAAA	1	--	ut31		1		WA	118
rs70773441,2	C,F,H,	--	98124715(+)	GCAGGA/CTTTTA	1	--	ut31 ese3		19		NA NS EA WA	2480
rs1387521181,2		--	98124808(+)	CCACAC/TTGGAA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for TLL2 (98124363 - 98273683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TLL2
     1 Indel: 101018

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLL2

DNA2.0 Custom Variant and Variant Library Synthesis for TLL2

Disorders / Diseases
for TLL2 gene

Publications
for TLL2 gene

PubMed articles for TLL2 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with TLL2)

Utopia: connect your pdf to the dynamic world of online information

1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
2. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
3. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. (PubMed id 11313359)^{1, 2} Uzel M.I.... Trackman P.C. (2001)
4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
5. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. (PubMed id 10479448)^{1, 2} Scott I.C....Greenspan D.S. (1999)
6. Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19. (PubMed id 10516436)^{1, 3} Scott I.C....Greenspan D.S. (1999)
7. Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases. (PubMed id 18824173)^{1, 9} Mac Sweeney A....Gerhartz B. (2008)
8. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)¹ Lesch K.P....Jacob C. (2008)
9. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)¹ Grupe A....Goate A. (2006)

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for TLL2 gene