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TLL2 Gene

protein-coding   GIFtS: 59
GCID: GC10M098114

Tolloid-Like 2

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tolloid-Like 21 2
KIAA09323 5
Tolloid-Like Protein 22
EC 3.4.24.-3
EC 3.4.248
EC 3.4.24.198

External Ids:    HGNC: 118441   Entrez Gene: 70932   Ensembl: ENSG000000955877   OMIM: 6067435   UniProtKB: Q9Y6L73   

Export aliases for TLL2 gene to outside databases

Previous GC identifers: GC10M097019 GC10M097358 GC10M098255 GC10M097788 GC10M091752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLL2 Gene:
This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin
family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or
chordin. (provided by RefSeq, Jul 2008)

GeneCards Summary for TLL2 Gene:
TLL2 (tolloid-like 2) is a protein-coding gene. Diseases associated with TLL2 include alzheimer's disease. GO annotations related to this gene include metalloendopeptidase activity and calcium ion binding. An important paralog of this gene is CUBN.

UniProtKB/Swiss-Prot: TLL2_HUMAN, Q9Y6L7
Function: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development.
Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis

Gene Wiki entry for TLL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLL2 gene promoter:
         TBP   AML1a   YY1   PPAR-gamma1   FOXO4   TFIID   FOXJ2 (long isoform)   c-Myb   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLL2 promoter sequence
   Search Chromatin IP Primers for TLL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23-q24

TLL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLL2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M098114:  view genomic region     (about GC identifiers)

Start:
98,124,363 bp from pter      End:
98,273,683 bp from pter
Size:
149,321 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TLL2_HUMAN, Q9Y6L7 (See protein sequence)
Recommended Name: Tolloid-like protein 2 precursor  
Size: 1015 amino acids; 113557 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Sequence caution: Sequence=BAA76776.2; Type=Erroneous initiation;
Secondary accessions: A6NDK0 Q2M1H1 Q6PJN5 Q9UQ00

Explore the universe of human proteins at neXtProt for TLL2: NX_Q9Y6L7

Explore proteomics data for TLL2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn171, Thr327, Asn361, Asn392, Asn628, Asn805
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TLL2 (Q9Y6L7) (see all 32)
     YLEVRDG  WEKHTCV  KDNGGCQ  CAYDYLE 


    See TLL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036597.1  
    ENSEMBL proteins: 
     ENSP00000350630  
    Reactome Protein details: Q9Y6L7

    TLL2 Human Recombinant Protein Products:

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    Novus Biologicals TLL2 Protein
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    Cloud-Clone Corp. Proteins for TLL2

    TLL2 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR000859 CUB_dom
     IPR015446 BMP_1/tolloid-like
     IPR024079 MetalloPept_cat_dom
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6L7

    ProtoNet protein and cluster: Q9Y6L7

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB001506 Astacin family signature


    UniProtKB/Swiss-Prot: TLL2_HUMAN, Q9Y6L7
    Similarity: Belongs to the peptidase M12A family
    Similarity: Contains 5 CUB domains
    Similarity: Contains 2 EGF-like domains


    TLL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLL2_HUMAN, Q9Y6L7
    Function: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development.
    Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis

         Genatlas biochemistry entry for TLL2:
    tolloid-like gene 2

         Enzyme Numbers (IUBMB): EC 3.4.24.-1 EC 3.4.24.192 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0008237metallopeptidase activity ----
    GO:0008270zinc ion binding IEA--
         
    TLL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tll2):
     muscle  no phenotypic analysis 

    TLL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tll2tm1.1Sjl for TLL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TLL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLL2

    miRNA
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    Block miRNA regulation of human, mouse, rat TLL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLL2 (see all 44):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-30d hsa-miR-507 hsa-miR-30a hsa-miR-532-5p hsa-miR-1183
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLL2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TLL2 (NM_012465)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLL2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLL2_HUMAN, Q9Y6L7: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    endoplasmic reticulum1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    TLL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Collagen biosynthesis and modifying enzymes
    Collagen biosynthesis and modifying enzymes0.75
    Anchoring fibril formation0.00
    Collagen formation0.75
    Crosslinking of collagen fibrils0.00
    Assembly of collagen fibrils and other multimeric structures0.62
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for TLL2
        Anchoring fibril formation
    Collagen biosynthesis and modifying enzymes
    Crosslinking of collagen fibrils
    Degradation of the extracellular matrix



    TLL2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TLL2
    Interactions:

        Search GeneGlobe Interaction Network for TLL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TLL2 (ENSP000003506304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP2ENSP000003681044STRING: ENSP00000368104
    BMP4ENSP000002454514STRING: ENSP00000245451
    SFRP2ENSP000002740634STRING: ENSP00000274063
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007275multicellular organismal development IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030154cell differentiation IEA--
    GO:0030198extracellular matrix organization TAS--

    TLL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLL2

    1 DrugBank Compound for TLL2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Carbobenzoxy-Pro-Lys-Phe-Y(Po2)-Ala-Pro-Ome-- --target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TLL2 gene: 
    NM_012465.3  

    Unigene Cluster for TLL2:

    Tolloid-like 2
    Hs.154296  [show with all ESTs]
    Unigene Representative Sequence: NM_012465
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357947(uc001kml.2) ENST00000506028 ENST00000469598(uc009xvf.2)


    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TLL2 (see all 44):
    hsa-miR-411* hsa-miR-379* hsa-miR-429 hsa-miR-30d hsa-miR-507 hsa-miR-30a hsa-miR-532-5p hsa-miR-1183
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLL2
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TLL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLL2
      QuantiTect SYBR Green Assays in human, mouse, rat TLL2
      QuantiFast Probe-based Assays in human, mouse, rat TLL2

    Additional mRNA sequence: 

    AB023149.2 AK026106.1 BC013871.2 BC030548.1 BC112341.1 BC112366.1 BC113577.1 

    3 DOTS entries:

    DT.70105453  DT.100742172  DT.91811968 

    Selected AceView cDNA sequences (see all 26):

    AI381881 NM_012465 BC013871 BC030548 AK026106 AB023149 CR606485 BX280499 
    BQ086177 AI791959 BI517607 AI199925 AW452288 BX369052 BF057747 AA582404 
    BG323677 AI652547 AF059516 BE745114 AL530453 AL530454 BI518327 AI889073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGATGTC
    TLL2 Expression
    About this image

    TLL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.154296
        Custom PCR Arrays for TLL2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLL2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tll21 , 5 tolloid-like 21, 5 86.3(n)1
    90.51(a)1
      19 (34.39 cM)5
    240871  NM_011904.31  NP_036034.11 
     410839815 
    chicken
    (Gallus gallus)
    Aves TLL26
    tolloid-like 2
    74(a)
    1 ↔ 1
    6(16142744-16223667)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    14(a)
    many ↔ many
    GL343567.1(84911-410791)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.362 X.laevis mRNA for xolloid 79(n)    Y09661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CR352286.16
    Uncharacterized protein
    12(a)
    many ↔ many
    19(45874989-46606132) ENSDARG00000077920
    fruit fly
    (Drosophila melanogaster)
    Insecta tok3 procollagen C-endopeptidase 53(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea T04G9.23 zinc metalloprotease 40(a)
    (best of 7)
      X(811505-815543)   --


    ENSEMBL Gene Tree for TLL2 (if available)
    TreeFam Gene Tree for TLL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLL2 gene
    CUBN2  CDCP22  PCOLCE2  BMP12  PCOLCE22  NETO22  MFRP2  NETO12  
    TLL12  
    3 SIMAP similar genes for TLL2 using alignment to 1 protein entry:     TLL2_HUMAN:
    BMP1    TLL1    NRP2

    TLL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLL2 (see all 3140)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559757481,2
    C--91788044(+) AAAAA-/A/A   
       A
    /AAA
    CAAAA
    2 -- int1 cds11NA 2
    rs571538961,2
    C--91889360(+) AAAAA-/A/AA  
            
    TACAA
    1 -- int11NA 2
    rs70911251,2
    C,F,H--98124038(+) GGCGAC/TGGGAG 1 -- int118Minor allele frequency- T:0.08NS EA NA WA CSA 789
    rs1861136851,2
    --98124086(+) GGTTTC/TGGCAG 1 -- int10--------
    rs1480211911,2
    --98124091(+) CGGCAG/TCAGAC 1 -- int10--------
    rs751780331,2
    C--98124094(+) CAGCAA/GACATC 1 -- int10--------
    rs1897921631,2
    C--98124315(+) GCACTA/TAAAGG 1 -- int10--------
    rs70739041,2
    C,F,H--98124394(+) CATCCT/GTTCTA 1 -- ut31 ese317Minor allele frequency- G:0.03NS EA NA WA CSA 934
    rs1501570811,2
    C--98124401(+) TCTAGC/GTAGAG 1 -- ut310--------
    rs769411621,2
    C,F--98124680(+) ATCAAT/CAGAAA 1 -- ut311Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for TLL2 (98124363 - 98273683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TLL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665154CNV Deletion23128226
    nsv513012CNV Insertion21212237
    esv1243485CNV Insertion17803354
    esv2622954CNV Insertion19546169
    nsv509362CNV Insertion20534489
    nsv831949CNV Gain17160897
    nsv831950CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLL2
    DNA2.0 Custom Variant and Variant Library Synthesis for TLL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606743    OMIM disorders: --

    1 disease for TLL2:    About MalaCards
    alzheimer's disease


    TLL2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TLL2
    Human Genome Epidemiology (HuGE) Navigator: TLL2 (1 document)

    Export disorders for TLL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLL2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TLL2)
        Utopia: connect your pdf to the dynamic
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    1. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    5. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. (PubMed id 11313359)1, 2 Uzel M.I.... Trackman P.C. (J. Biol. Chem. 2001)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    7. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. (PubMed id 10479448)1, 2 Scott I.C....Greenspan D.S. (Dev. Biol. 1999)
    8. Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32--&gt;q33 and 10q23--&gt;q24 and assignment of murine Tll2 to chromosome 19. (PubMed id 10516436)1, 3 Scott I.C....Greenspan D.S. (Cytogenet. Cell Genet. 1999)
    9. Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases. (PubMed id 18824173)1, 9 Mac Sweeney A.... Gerhartz B. (J. Mol. Biol. 2008)
    10. Cross-species genetics converge to TLL2 for mouse avoidance behavior and human bipolar disorder. (PubMed id 23777486)1 de Mooij-van Malsen J.G....Kas M.J. (Genes Brain Behav. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7093 HGNC: 11844 AceView: TLL2 Ensembl:ENSG00000095587 euGenes: HUgn7093
    ECgene: TLL2 H-InvDB: TLL2

    (According to HUGE)
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    HUGE: KIAA0932

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TLL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLL2 gene:
    Search GeneIP for patents involving TLL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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