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TLK2 Gene

protein-coding   GIFtS: 63
GCID: GC17P060536

Tousled-Like Kinase 2

  Search for TLK2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tousled-Like Kinase 21 2 3     Serine/Threonine-Protein Kinase Tousled-Like 22
HsHPK2 3     PKU-alpha3
EC 2.7.11.13 8     EC 2.7.118
PKU-ALPHA2     

External Ids:    HGNC: 118421   Entrez Gene: 110112   Ensembl: ENSG000001468727   OMIM: 6084395   UniProtKB: Q86UE83   

Export aliases for TLK2 gene to outside databases

Previous GC identifers: GC17P060240 GC17M034403 GC17P060897 GC17P061029 GC17P061009 GC17P057889 GC17P060556 GC17P055922


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLK2 Gene:
This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein
is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the
levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage
caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for TLK2 Gene:
TLK2 (tousled-like kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is TTK.

UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8
Function: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA
replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors
ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing
chromatin assembly. Negative regulator of amino acid starvation-induced autophagy

Gene Wiki entry for TLK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLK2 gene promoter:
         Sp1   Pax-5   GATA-3   Tal-1beta   HEN1   Nkx6-1   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TLK2 promoter sequence
   Search Chromatin IP Primers for TLK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q23

TLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLK2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P060536:  view genomic region     (about GC identifiers)

Start:
60,536,019 bp from pter      End:
60,692,842 bp from pter
Size:
156,824 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase tousled-like 2  
Size: 772 amino acids; 87661 Da
Cofactor: Magnesium
Subunit: Monomer and heterodimer with TLK1. Interacts with ASF1A and ASF1B. Association with 14-3-3 proteins such
as YWHAZ regulates subcellular location. May also interact with FEZ1/LZTS1 and FEZ2
Sequence caution: Sequence=AAF03095.1; Type=Erroneous initiation; Sequence=AAH44925.2; Type=Erroneous initiation;
Sequence=BAA20561.1; Type=Erroneous initiation;
Secondary accessions: D3DU07 Q9UKI7 Q9Y4F7
Alternative splicing: 3 isoforms:  Q86UE8-1   Q86UE8-2   Q86UE8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLK2: NX_Q86UE8

Explore proteomics data for TLK2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Ser-750, probably by CHEK11
  • Ubiquitination2 at Lys156
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TLK2 (Q86UE8) (see all 16)
     IKITDFG  KPGNILL  IKITDFGL  LEKYKERLN 


    See TLK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271262.1  NP_001271292.1  NP_006843.2  

    ENSEMBL proteins: 
     ENSP00000463595   ENSP00000463814   ENSP00000464557   ENSP00000462637   ENSP00000464516  
     ENSP00000275780   ENSP00000316512   ENSP00000340800   ENSP00000463986   ENSP00000462036  
     ENSP00000462851   ENSP00000442311  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: tousled-like kinase 2
    Tousled-like kinase (TLK) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR027086 TLK

    Graphical View of Domain Structure for InterPro Entry Q86UE8

    ProtoNet protein and cluster: Q86UE8

    UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TLK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLK2_HUMAN, Q86UE8
    Function: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA
    replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors
    ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing
    chromatin assembly. Negative regulator of amino acid starvation-induced autophagy
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Cell cycle-regulated, with maximal activity in the S-phase. Rapidly and transiently inhibited
    by phosphorylation following the generation of DNA double-stranded breaks during S-phase, probably by CHEK1,
    possibly at Ser-750. This inhibition is cell cycle checkpoint- and ATM-dependent

         Genatlas biochemistry entry for TLK2:
    tousled-like kinase 2,nuclear serine/threonine kinase PKU alpha

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA12660173
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IDA12660173
         
    Find genes that share ontologies with TLK2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for TLK2:
     Decreased G3BP1 protein expres  Decreased Hepatitis C virus re  Decreased focal adhesion (FA)   Increased cell death HMECs cel 
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Tlk2 (no phenotypes)

    Find genes that share phenotypes with TLK2           About GenesLikeMe

    Animal Models:
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    hsa-mir-93-3p (MIRT038762)

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    Selected qRT-PCR Assays for microRNAs that regulate TLK2 (see all 114):
    hsa-miR-124* hsa-miR-548j hsa-miR-607 hsa-miR-128 hsa-miR-1273d hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLK2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLK2_HUMAN, Q86UE8: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the
    cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region
    at S phase and in the nucleus at late G2
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005882intermediate filament IDA10455159
    GO:0048471perinuclear region of cytoplasm IDA10455159

    Find genes that share ontologies with TLK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    2p53 signaling pathway
    DNA damage response0.41
    3Packaging Of Telomere Ends
    Histone modification0.31

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TLK2
        Chks in Checkpoint Regulation

    1 BioSystems Pathway for TLK2
        DNA damage response



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TLK2
    Interactions:

        Search GeneGlobe Interaction Network for TLK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for TLK2 (Q86UE81, 3 ENSP000002757804) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF7Q929851, 3, ENSP000003294114EBI-1047967,EBI-968267 I2D: score=1 STRING: ENSP00000329411
    IRF4Q153061, 3, ENSP000003703434EBI-1047967,EBI-751345 I2D: score=1 STRING: ENSP00000370343
    ASF1AQ9Y2943, ENSP000002295954I2D: score=3 STRING: ENSP00000229595
    TLK1Q9UKI83, ENSP000004110994I2D: score=2 STRING: ENSP00000411099
    AURKAO149653, ENSP000002169114I2D: score=1 STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001672regulation of chromatin assembly or disassembly IDA12660173
    GO:0006468protein phosphorylation IDA12660173
    GO:0006974cellular response to DNA damage stimulus IDA12660173
    GO:0007049cell cycle IEA--
    GO:0007059chromosome segregation IMP--

    Find genes that share ontologies with TLK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLK2

    3 HMDB Compounds for TLK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 Novoseek inferred chemical compound relationships for TLK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 45 6 10908660 (2), 1958641 (1), 7531704 (1), 9342324 (1)
    guanylate 29.6 2 9837759 (1), 7913035 (1)
    threonine 27.9 2 10843813 (1), 12612079 (1)
    proline 21.1 2 12525647 (1), 10843813 (1)
    serine 12.8 2 10843813 (1), 12612079 (1)
    glutamate 0 1 10843813 (1)



    Find genes that share compounds with TLK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLK2 gene (4 alternative transcripts): 
    NM_001284333.1  NM_001284363.1  NM_006852.3  NM_001112707.1  

    Unigene Cluster for TLK2:

    Tousled-like kinase 2
    Hs.445078  [show with all ESTs]
    Unigene Representative Sequence: NM_006852
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000582809(uc002izx.4 uc010wpd.2) ENST00000583843 ENST00000579450
    ENST00000577616 ENST00000582195 ENST00000580705 ENST00000346027(uc002izz.4 uc002jaa.4)
    ENST00000326270(uc010ddp.3) ENST00000343388 ENST00000583690 ENST00000581041
    ENST00000578697 ENST00000581286 ENST00000584367 ENST00000582660 ENST00000578931
    ENST00000583310 ENST00000580203
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    hsa-miR-124* hsa-miR-548j hsa-miR-607 hsa-miR-128 hsa-miR-1273d hsa-miR-149 hsa-miR-3150b-3p hsa-miR-3613-3p
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    Additional mRNA sequence: 

    AB004884.1 AF162667.1 AK300586.1 BC013736.2 BC044925.1 BC060511.1 BX647225.1 

    22 DOTS entries:

    DT.440811  DT.91748952  DT.100761762  DT.455309  DT.100859126  DT.101971809  DT.120989791  DT.91691444 
    DT.91943940  DT.97854773  DT.91749826  DT.97786574  DT.99991583  DT.75174097  DT.120989738  DT.120989760 
    DT.120989769  DT.120989789  DT.92032032  DT.95183639  DT.120989785  DT.87046990 

    Selected AceView cDNA sequences (see all 211):

    NM_006852 Z42010 BF061293 AA126835 AA421531 AU119586 CD673255 BX647225 
    BM768391 CB409242 AA195043 BU684048 AI194090 AX775747 AX775745 AW150722 
    AA346878 AI305159 AL041560 AI283703 BX642548 Z38296 AI380171 AI421917 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TLK2 Expression
    About this image


    TLK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    TLK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445078

    UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8
    Tissue specificity: Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle.
    Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral
    blood leukocytes

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TLK2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tlk21 , 5 tousled-like kinase 2 (Arabidopsis)1, 5 93.6(n)1
    99.33(a)1
      11 (68.61 cM)5
    240861  NM_001112705.11  NP_001106176.11 
     1051788075 
    chicken
    (Gallus gallus)
    Aves TLK21 tousled-like kinase 2 87.17(n)
    97.02(a)
      419949  XM_418070.4  XP_418070.3 
    lizard
    (Anolis carolinensis)
    Reptilia TLK26
    tousled-like kinase 2
    96(a)
    1 ↔ 1
    6(66043544-66085878)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420051392   -- 79.16(n)    142005139 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.76492 Danio rerio pKU-alpha protein kinase mRNA, complete more 76.14(n)    AF265344.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH079103
    tlk1
    protein amino acid phosphorylation
    protein kinase3
    Tousled-like kinase1
    75(a)3
    60.88(n)1
    64.33(a)1
      3182061  NM_001144681.31  NP_001138153.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tlk-11 tlk-1 54.08(n)
    51.66(a)
      176369  NM_001047379.1  NP_001040844.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MPS16
    Dual-specificity kinase required for spindle pole ...
    16(a)
    1 → many
    IV(400997-403291) YDL028C
    corn
    (Zea mays)
    Liliopsida Zm.103472 Zea mays tousled-like kinase 1 (MTK-1) mRNA, partial more 75.93(n)    AF012888.1 


    ENSEMBL Gene Tree for TLK2 (if available)
    TreeFam Gene Tree for TLK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLK2 gene
    TTK2  TLK12  
    Selected SIMAP similar genes for TLK2 using alignment to 10 protein entries:     TLK2_HUMAN (see all proteins) (see all similar genes):
    TLK1    PHKG2    MAPK3    CDK7    BRSK2    RPS6KA2
    CAMK1    STK11    DAPK1    ULK3    DAPK3    NUAK1
    DKFZp564L2416    MARK2    NEK9    STK17A    STK36    ULK1

    Find genes that share paralogs with TLK2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for TLK2
    PGOHUM00000257777 PGOHUM00000263187


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLK2 (see all 2664)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412214
    A gastric adenocarcinoma sample4--see VAR_0412212 F L mis40--------
    rs1872241791,2
    --60554471(+) TTTTTA/TAAAAA 2 -- us2k10--------
    rs1470793651,2
    --60554584(+) CGCCCG/TAACAG 2 -- us2k10--------
    rs1920444901,2
    --60554652(+) TACCCC/GCAACC 2 -- us2k10--------
    rs1384839911,2
    --60554737(+) GGGATC/GTGGAG 2 -- us2k10--------
    rs1845117281,2
    --60554879(+) ATATGA/GAAGAA 2 -- us2k10--------
    rs1434173131,2
    --60555000(+) GCTTGC/TAGTCC 2 -- us2k10--------
    rs1482953111,2
    --60555002(+) TTGTAC/GTCCTT 2 -- us2k10--------
    rs29232541,2
    --60555096(+) AGGGGA/CGCCGG 2 -- us2k10--------
    rs29232551,2
    --60555127(+) TTGGCC/GTTGGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLK2 (60536019 - 60692842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TLK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2114CNV Insertion18451855
    nsv509664CNV Insertion20534489
    nsv908680CNV Loss21882294
    nsv516636CNV Loss19592680
    esv1421317OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): TLK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLK2
    DNA2.0 Custom Variant and Variant Library Synthesis for TLK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608439    OMIM disorders: --


    Find genes that share disorders with TLK2           About GenesLikeMe

    Genetic Association Database (GAD): TLK2
    Human Genome Epidemiology (HuGE) Navigator: TLK2 (3 documents)

    Export disorders for TLK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLK2 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with TLK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian homologues of the plant tousled gene code for cell-cycle- regulated kinases with maximal activities linked to ongoing DNA replication. (PubMed id 10523312)1, 2, 3 Sillje H.H.W.... Nigg E.A. (EMBO J. 1999)
    2. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. (PubMed id 9427565)1, 2, 3 Yamakawa A.... Date T. (Gene 1997)
    3. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. (PubMed id 11470414)1, 2, 9 Sillje H.H.W. and Nigg E.A. (Curr. Biol. 2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases. (PubMed id 20016786)1, 2 Pilyugin M.... Moshkin Y.M. (PLoS ONE 2009)
    6. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1, 2 Assmann E.M.... Kobarg J. (J. Biol. Chem. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. (PubMed id 12660173)1, 2 Groth A....Hansen K. (EMBO J. 2003)
    9. Nuclear localization of protein kinase U-alpha is regulated by 14-3- 3. (PubMed id 10455159)1, 2 Zhang S.... Muslin A.J. (J. Biol. Chem. 1999)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11011 HGNC: 11842 AceView: TLK2 Ensembl:ENSG00000146872 euGenes: HUgn11011
    ECgene: TLK2 H-InvDB: TLK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TLK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLK2 gene:
    Search GeneIP for patents involving TLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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