TLK2 Gene
protein-coding GIFtS: 57
GCID: GC17P060556
|
|
tousled-like kinase 2
| |
Aliases
for TLK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tousled-Like Kinase 21 2 3 | | Serine/Threonine Kinase2 | | PKU-ALPHA1 2 | | Serine/Threonine-Protein Kinase Tousled-Like 22 | | HsHPK2 3 | | PKU-Alpha1 | | EC 2.7.11.13 8 | | EC 2.7.118 | | MGC444501 | | |
Export aliases for TLK2 gene to outside databasesPrevious GC identifers: GC17P060240 GC17M034403 GC17P060897 GC17P061029 GC17P061009 GC17P057889 GC17P055922 |
Summaries
for TLK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TLK2:
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentiallyinvolved in the regulation of chromatin assembly.(supplied by OMIM, Apr 2004)
UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8Function: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNAreplication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1AAND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatinassembly. Negative regulator of amino acid starvation-induced autophagy
Gene Wiki entry for TLK2
|
Genomic Views
for TLK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TLK2 gene promoter:
Sp1 Pax-5 GATA-3 Tal-1beta HEN1 Nkx6-1 POU2F1 POU2F1a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TLK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23TLK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P060556: view genomic region
(about GC identifiers)
Start:
|
60,536,019 bp from pter |
End:
|
60,692,842 bp from pter |
Size:
|
156,824 bases |
Orientation:
|
plus strand |
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Proteins
for TLK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase tousled-like 2 Size: 772 amino acids; 87661 Da
Cofactor: Magnesium
Subunit: Monomer and heterodimer with TLK1. Interacts with ASF1A and ASF1B. Association with 14-3-3 proteins such asYWHAZ regulates subcellular location. May also interact with FEZ1/LZTS1 and FEZ2
Subcellular location: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with thecytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at Sphase and in the nucleus at late G2
Sequence caution: Sequence=AAF03095.1; Type=Erroneous initiation; Sequence=AAH44925.2; Type=Erroneous initiation;Sequence=BAA20561.1; Type=Erroneous initiation;
Secondary accessions: D3DU07 Q9UKI7 Q9Y4F7Alternative splicing: 3 isoforms: Q86UE8-1 Q86UE8-2 Q86UE8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TLK2: NX_Q86UE8
Post-translational modifications:
Phosphorylated at Ser-750, probably by CHEK11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86UE8
4/16 DME Specific Peptides for TLK2 (Q86UE8) (see all 16)
TLK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001106178.1 NP_006843.2
ENSEMBL proteins: ENSP00000463595 ENSP00000463814 ENSP00000464557 ENSP00000462637 ENSP00000464516 ENSP00000275780 ENSP00000316512 ENSP00000340800 ENSP00000463986 ENSP00000462036 ENSP00000462851 ENSP00000442311
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TLK2 for ontologies About GeneDecksing
TLK2 Antibody Products:
Assay Products for TLK2: |
Protein
Domains /
Families
for TLK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TLK2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q86UE8ProtoNet protein and cluster: Q86UE8 UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for TLK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8Function: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNAreplication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1AAND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatinassembly. Negative regulator of amino acid starvation-induced autophagyCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Cell cycle-regulated, with maximal activity in the S-phase. Rapidly and transiently inhibited byphosphorylation following the generation of DNA double-stranded breaks during S-phase, probably by CHEK1, possibly atSer-750. This inhibition is cell cycle checkpoint- and ATM-dependent Genatlas biochemistry entry for TLK2:tousled-like kinase 2,nuclear serine/threonine kinase PKU alpha
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLK2 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TLK2 (NM_001112707) | |  | Sino Biological Human cDNA Clone for TLK2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLK2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TLK2 for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for TLK2:
Animal Models:
1 MGI phenotypic allele  for Tlk2 (no phenotypes)
TLK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TLK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chks in Checkpoint Regulation | | | 2 | p53 signaling pathway | | | 3 | Signal transduction Activin A signaling regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TLK2
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TLK2
1  BioSystems Pathway for TLK2
TLK2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for TLK2 (Q86UE81, 3 ENSP000002757804) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
TLK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TLK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TLK2 for compounds About GeneDecksing
 Browse Tocris compounds for TLK2
3 HMDB Compounds for TLK2 About this table
6 Novoseek chemical compound relationships for TLK2 gene About this table
Search CenterWatch for drugs/clinical trials and news about TLK2
|
Transcripts
for TLK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TLK2 gene (2 alternative transcripts): NM_001112707.1 NM_006852.3 Unigene Cluster for TLK2: Tousled-like kinase 2 Hs.445078 [show with all ESTs]Unigene Representative Sequence: NM_00685218/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000582809(uc002izx.4 uc010wpd.2) ENST00000583843 ENST00000579450
ENST00000577616 ENST00000582195 ENST00000580705 ENST00000346027(uc002izz.4 uc002jaa.4)
ENST00000326270(uc010ddp.3) ENST00000343388 ENST00000583690 ENST00000581041
ENST00000578697 ENST00000581286 ENST00000584367 ENST00000582660 ENST00000578931
ENST00000583310 ENST00000580203
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLK2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLK2 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TLK2 (NM_001112707) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLK2 |
Additional cDNA sequence: AB004884.1 AF162667.1 AK300586.1 BC013736.2 BC044925.1 BC060511.1 BX647225.1 22 DOTS entries: DT.440811 DT.91748952 DT.100761762 DT.455309 DT.100859126 DT.101971809 DT.120989791 DT.91691444 DT.91943940 DT.97854773 DT.91749826 DT.97786574 DT.99991583 DT.75174097 DT.120989738 DT.120989760 DT.120989769 DT.120989789 DT.92032032 DT.95183639 DT.120989785 DT.87046990 24/211 AceView cDNA sequences (see all 211): AI187719 AI194090 AI421917 AX775745 BM832689 AX775747 AA195043 BU684048 BU730235 AI283703 AA430024 BE328215 BC044925 BM980571 AI380171 BM739883 CD367299 BC013736 AA126768 AL041560 BX642548 AI753383 BX647225 AA346878
GeneLoc Exon Structure
|
Expression
for TLK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TLK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TLK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLK2
SOURCE GeneReport for Unigene cluster: Hs.445078
UniProtKB/Swiss-Prot: TLK2_HUMAN, Q86UE8Tissue specificity: Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highlyexpressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral bloodleukocytes
SABiosciences Custom PCR Arrays for TLK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLK2 |
Orthologs
for TLK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TLK2 gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TLK21 |
tousled-like kinase 2 |
87.11(n)
96.93(a) |
|
419949 XM_418070.3 XP_418070.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TLK26 |
-- |
93(a) |
1 ↔ 1 |
6(66043546-66081968) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
1420051392 |
-- |
79.16(n) |
|
142005139 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.76492 |
Danio rerio pKU-alpha protein kinase mRNA, complete more |
76.14(n) |
|
AF265344.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
BcDNA:GH079103
tlk1 |
protein amino acid phosphorylation protein
kinase3
Tousled-like kinase1 |
75(a)3
60.71(n)1
64.08(a)1 |
|
3182061 NM_001144681.31 NP_001138153.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
tlk-11 |
Protein TLK-1 |
54.05(n)
50.97(a) |
|
176369 NM_066744.2 NP_499145.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TSL1 |
serine/threonine-protein kinase TOUSLED |
54.47(n)
51.22(a) |
|
832217 NM_122101.1 NP_568405.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g07498001 |
hypothetical protein |
51.99(n)
47.1(a) |
|
4334117 NM_001057813.1 NP_001051278.1 |
ENSEMBL Gene Tree for TLK2 (if available)
TreeFam Gene Tree for TLK2 (if available) |
Paralogs
for TLK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TLK2 gene
- TTK2 TLK12
18/21 SIMAP similar genes for TLK2 using alignment to 10 protein entries: TLK2_HUMAN (see all proteins)
(see all similar genes):TLK1 PHKG2 MAPK3 CDK7 BRSK2 RPS6KA2
CAMK1 STK11 DAPK1 ULK3 NUAK1 DKFZp564L2416
MARK2 NEK9 STK17A STK36 ULK1 BRAF
TLK2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TLK2
PGOHUM00000257777 PGOHUM00000263187
|
Genomic Variants
for TLK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TLK2 (60536019 - 60692842 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TLK2
1 CNV: 49906 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLK2 |
|
Disorders
/ Diseases
for TLK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TLK2 for disorders About GeneDecksing
OMIM gene information: 608439
OMIM disorders: --
9  diseases for TLK2: About MalaCardsosteochondrosis pancreatic cancer pancreatitis pneumonia
tuberculosis immunodeficiency malaria neuronitis
mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: TLK2 (3 documents)
Export disorders for TLK2 gene to outside databases
|
Publications
for TLK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TLK2 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with TLK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian homologues of the plant tousled gene code for cell-cycle- regulated kinases with maximal activities linked to ongoing DNA replication. (PubMed id 10523312)1, 2, 3 Sillje H.H.W.... Nigg E.A. (1999)
- cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. (PubMed id 9427565)1, 2, 3 Yamakawa A.... Date T. (1997)
- Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. (PubMed id 11470414)1, 2, 9 Sillje H.H. and Nigg E.A. (2001)
- Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases. (PubMed id 20016786)1, 2 Pilyugin M....Moshkin Y.M. (2009)
- FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. (PubMed id 16484223)1, 2 Assmann E.M.... Kobarg J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. (PubMed id 12660173)1, 2 Groth A....Hansen K. (2003)
- Nuclear localization of protein kinase U-alpha is regulated by 14-3-3. (PubMed id 10455159)1, 2 Zhang S....Muslin A.J. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)2 McKnight N.C.... Tooze S.A. (2012)
|
External Searches for TLK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TLK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TLK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TLK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TLK2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TLK2 gene:
Search GeneIP for patents involving TLK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TLK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TLK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLK2 | | | OriGene Protein Over-expression Lysate for TLK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TLK2 | | OriGene 3'-UTR Clone for TLK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TLK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TLK2 | | OriGene Custom Protein Services for TLK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLK2 |
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| | | | Search Tocris compounds for TLK2 |
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 | | | TLK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLK2 |
|  |  |  | | | | ThermoFisher Antibodies for TLK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLK2 |
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