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Aliases for TLK2 Gene

Aliases for TLK2 Gene

  • Tousled Like Kinase 2 2 3 5
  • Tousled-Like Kinase 2 2 3 4
  • EC 2.7.11.1 4 63
  • PKU-ALPHA 3 4
  • HsHPK 3 4
  • EC 2.7.11 63

External Ids for TLK2 Gene

Previous GeneCards Identifiers for TLK2 Gene

  • GC17P060240
  • GC17M034403
  • GC17P060897
  • GC17P061029
  • GC17P061009
  • GC17P057889
  • GC17P060556
  • GC17P055922
  • GC17P060536

Summaries for TLK2 Gene

Entrez Gene Summary for TLK2 Gene

  • This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for TLK2 Gene

TLK2 (Tousled Like Kinase 2) is a Protein Coding gene. Diseases associated with TLK2 include severe combined immune deficiency. Among its related pathways are Chks in Checkpoint Regulation and p53 signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TLK1.

UniProtKB/Swiss-Prot for TLK2 Gene

  • Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Gene Wiki entry for TLK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLK2 Gene

Genomics for TLK2 Gene

Regulatory Elements for TLK2 Gene

Enhancers for TLK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TLK2 on UCSC Golden Path with GeneCards custom track

Promoters for TLK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLK2 Gene

Chromosome:
17
Start:
62,458,658 bp from pter
End:
62,615,481 bp from pter
Size:
156,824 bases
Orientation:
Plus strand

Genomic View for TLK2 Gene

Genes around TLK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLK2 Gene

Proteins for TLK2 Gene

  • Protein details for TLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE8-TLK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase tousled-like 2
    Protein Accession:
    Q86UE8
    Secondary Accessions:
    • D3DU07
    • Q9UKI7
    • Q9Y4F7

    Protein attributes for TLK2 Gene

    Size:
    772 amino acids
    Molecular mass:
    87661 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer and heterodimer with TLK1. Interacts with ASF1A and ASF1B. Association with 14-3-3 proteins such as YWHAZ regulates subcellular location. May also interact with FEZ1/LZTS1 and FEZ2.
    SequenceCaution:
    • Sequence=AAF03095.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH44925.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA20561.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLK2 Gene

Proteomics data for TLK2 Gene at MOPED

Post-translational modifications for TLK2 Gene

Domains & Families for TLK2 Gene

Gene Families for TLK2 Gene

Suggested Antigen Peptide Sequences for TLK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86UE8

UniProtKB/Swiss-Prot:

TLK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TLK2: view

Function for TLK2 Gene

Molecular function for TLK2 Gene

GENATLAS Biochemistry:
tousled-like kinase 2,nuclear serine/threonine kinase PKU alpha
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Cell cycle-regulated, with maximal activity in the S-phase. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase, probably by CHEK1, possibly at Ser-750. This inhibition is cell cycle checkpoint- and ATM-dependent.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Enzyme Numbers (IUBMB) for TLK2 Gene

genes like me logo Genes that share phenotypes with TLK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TLK2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLK2 Gene

Localization for TLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLK2 Gene

Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLK2 Gene COMPARTMENTS Subcellular localization image for TLK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with TLK2: view

Pathways & Interactions for TLK2 Gene

genes like me logo Genes that share pathways with TLK2: view

Pathways by source for TLK2 Gene

1 BioSystems pathway for TLK2 Gene
1 Qiagen pathway for TLK2 Gene

Gene Ontology (GO) - Biological Process for TLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001672 regulation of chromatin assembly or disassembly IDA 12660173
GO:0006468 protein phosphorylation IEA,IDA 12660173
GO:0016568 chromatin modification IEA --
GO:0018105 peptidyl-serine phosphorylation IDA 20016786
genes like me logo Genes that share ontologies with TLK2: view

No data available for SIGNOR curated interactions for TLK2 Gene

Drugs & Compounds for TLK2 Gene

(6) Drugs for TLK2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(3) Additional Compounds for TLK2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TLK2: view

Transcripts for TLK2 Gene

Unigene Clusters for TLK2 Gene

Tousled-like kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLK2 Gene

No ASD Table

Relevant External Links for TLK2 Gene

GeneLoc Exon Structure for
TLK2
ECgene alternative splicing isoforms for
TLK2

Expression for TLK2 Gene

mRNA expression in normal human tissues for TLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLK2 Gene

This gene is overexpressed in CD8 Tcells (11.0), Peripheral blood mononuclear cells (9.3), Breast (8.6), Lymph node (8.2), Fetal ovary (7.9), and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLK2 Gene



SOURCE GeneReport for Unigene cluster for TLK2 Gene Hs.445078

mRNA Expression by UniProt/SwissProt for TLK2 Gene

Q86UE8-TLK2_HUMAN
Tissue specificity: Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with TLK2: view

Protein tissue co-expression partners for TLK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TLK2 Gene

Orthologs for TLK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TLK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLK2 35
  • 95.91 (n)
  • 99.47 (a)
TLK2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLK2 35
  • 95.6 (n)
  • 99.47 (a)
TLK2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlk2 35
  • 93.6 (n)
  • 99.33 (a)
Tlk2 16
Tlk2 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLK2 35
  • 99.91 (n)
  • 99.87 (a)
TLK2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlk2 35
  • 93.56 (n)
  • 99.47 (a)
oppossum
(Monodelphis domestica)
Mammalia TLK2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves TLK2 35
  • 87.17 (n)
  • 97.02 (a)
TLK2 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLK2 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlk2 35
  • 80.65 (n)
  • 94.88 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.7649 35
tlk2 35
  • 74.06 (n)
  • 85.76 (a)
tlk2 36
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH07910 37
  • 75 (a)
tlk 35
  • 60.88 (n)
  • 64.33 (a)
tlk 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tlk-1 35
  • 54.08 (n)
  • 51.66 (a)
tlk-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPS1 36
  • 16 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.10347 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14850 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.566 36
  • 65 (a)
OneToMany
Species with no ortholog for TLK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLK2 Gene

ENSEMBL:
Gene Tree for TLK2 (if available)
TreeFam:
Gene Tree for TLK2 (if available)

Paralogs for TLK2 Gene

Paralogs for TLK2 Gene

Pseudogenes.org Pseudogenes for TLK2 Gene

genes like me logo Genes that share paralogs with TLK2: view

Variants for TLK2 Gene

Sequence variations from dbSNP and Humsavar for TLK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_041216 -
VAR_041217 -
VAR_041218 -
VAR_041219 -
VAR_041220 -

Structural Variations from Database of Genomic Variants (DGV) for TLK2 Gene

Variant ID Type Subtype PubMed ID
esv1421317 OTHER Inversion 17803354
nsv516636 CNV Loss 19592680
nsv509664 CNV Insertion 20534489
nsv2114 CNV Insertion 18451855
nsv908680 CNV Loss 21882294

Variation tolerance for TLK2 Gene

Residual Variation Intolerance Score: 18.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLK2 Gene

HapMap Linkage Disequilibrium report
TLK2
Human Gene Mutation Database (HGMD)
TLK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLK2 Gene

Disorders for TLK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TLK2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
severe combined immune deficiency
  • severe combined immunodeficiency
- elite association - COSMIC cancer census association via MalaCards
Search TLK2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLK2

Genetic Association Database (GAD)
TLK2
Human Genome Epidemiology (HuGE) Navigator
TLK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLK2
genes like me logo Genes that share disorders with TLK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLK2 Gene

Publications for TLK2 Gene

  1. Mammalian homologues of the plant tousled gene code for cell-cycle- regulated kinases with maximal activities linked to ongoing DNA replication. (PMID: 10523312) Sillje H.H.W. … Nigg E.A. (EMBO J. 1999) 2 3 4 67
  2. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. (PMID: 11470414) Sillje H.H.W. … Nigg E.A. (Curr. Biol. 2001) 3 23
  3. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. (PMID: 9427565) Yamakawa A. … Date T. (Gene 1997) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TLK2 Gene

Sources for TLK2 Gene

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