Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLK2 Gene

Aliases for TLK2 Gene

  • Tousled-Like Kinase 2 2 3 4
  • EC 2.7.11.1 4 64
  • PKU-ALPHA 3 4
  • HsHPK 3 4
  • Serine/Threonine-Protein Kinase Tousled-Like 2 3
  • EC 2.7.11 64

External Ids for TLK2 Gene

Summaries for TLK2 Gene

Entrez Gene Summary for TLK2 Gene

  • This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for TLK2 Gene

TLK2 (Tousled-Like Kinase 2) is a Protein Coding gene. Among its related pathways are p53 signaling pathway and Chks in Checkpoint Regulation. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is TLK1.

UniProtKB/Swiss-Prot for TLK2 Gene

  • Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Gene Wiki entry for TLK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLK2 Gene

Genomics for TLK2 Gene

Genomic Location for TLK2 Gene

Start:
62,458,658 bp from pter
End:
62,615,481 bp from pter
Size:
156,824 bases
Orientation:
Plus strand

Genomic View for TLK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLK2 Gene

Regulatory Elements for TLK2 Gene

Proteins for TLK2 Gene

  • Protein details for TLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UE8-TLK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase tousled-like 2
    Protein Accession:
    Q86UE8
    Secondary Accessions:
    • D3DU07
    • Q9UKI7
    • Q9Y4F7

    Protein attributes for TLK2 Gene

    Size:
    772 amino acids
    Molecular mass:
    87661 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer and heterodimer with TLK1. Interacts with ASF1A and ASF1B. Association with 14-3-3 proteins such as YWHAZ regulates subcellular location. May also interact with FEZ1/LZTS1 and FEZ2.
    SequenceCaution:
    • Sequence=AAF03095.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH44925.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA20561.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLK2 Gene

Proteomics data for TLK2 Gene at MOPED

Post-translational modifications for TLK2 Gene

Domains for TLK2 Gene

Gene Families for TLK2 Gene

UniProtKB/Swiss-Prot:

TLK2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q86UE8
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:
    • Q86UE8
genes like me logo Genes that share domains with TLK2: view

Function for TLK2 Gene

Molecular function for TLK2 Gene

GENATLAS Biochemistry: tousled-like kinase 2,nuclear serine/threonine kinase PKU alpha
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Cell cycle-regulated, with maximal activity in the S-phase. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase, probably by CHEK1, possibly at Ser-750. This inhibition is cell cycle checkpoint- and ATM-dependent.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.

Enzyme Numbers (IUBMB) for TLK2 Gene

Gene Ontology (GO) - Molecular Function for TLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 12660173
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 21903422
GO:0005524 ATP binding IDA 12660173
genes like me logo Genes that share ontologies with TLK2: view
genes like me logo Genes that share phenotypes with TLK2: view

miRNA for TLK2 Gene

miRTarBase miRNAs that target TLK2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TLK2 Gene

Localization for TLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLK2 Gene

Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLK2 Gene COMPARTMENTS Subcellular localization image for TLK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10455159
GO:0005730 nucleolus --
GO:0005882 intermediate filament IDA 10455159
GO:0048471 perinuclear region of cytoplasm IDA 10455159
genes like me logo Genes that share ontologies with TLK2: view

Pathways for TLK2 Gene

genes like me logo Genes that share pathways with TLK2: view

Pathways by source for TLK2 Gene

1 Qiagen pathway for TLK2 Gene
1 BioSystems pathway for TLK2 Gene

Gene Ontology (GO) - Biological Process for TLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001672 regulation of chromatin assembly or disassembly IDA 12660173
GO:0006468 protein phosphorylation IDA 12660173
GO:0006974 cellular response to DNA damage stimulus IDA 12660173
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IMP 20705056
genes like me logo Genes that share ontologies with TLK2: view

Compounds for TLK2 Gene

(3) HMDB Compounds for TLK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(6) Novoseek inferred chemical compound relationships for TLK2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 45 5
guanylate 29.6 2
threonine 27.9 2
proline 21.1 2
serine 12.8 2
genes like me logo Genes that share compounds with TLK2: view

Transcripts for TLK2 Gene

Unigene Clusters for TLK2 Gene

Tousled-like kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLK2 Gene

No ASD Table

Relevant External Links for TLK2 Gene

GeneLoc Exon Structure for
TLK2
ECgene alternative splicing isoforms for
TLK2

Expression for TLK2 Gene

mRNA expression in normal human tissues for TLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLK2 Gene

SOURCE GeneReport for Unigene cluster for TLK2 Gene Hs.445078

mRNA Expression by UniProt/SwissProt for TLK2 Gene

Q86UE8-TLK2_HUMAN
Tissue specificity: Ubiquitous. Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle. Highly expressed in testis. Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes.
genes like me logo Genes that share expressions with TLK2: view

Orthologs for TLK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TLK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLK2 36
  • 99.91 (n)
  • 99.87 (a)
TLK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLK2 36
  • 95.91 (n)
  • 99.47 (a)
TLK2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLK2 36
  • 95.6 (n)
  • 99.47 (a)
TLK2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlk2 36
  • 93.6 (n)
  • 99.33 (a)
Tlk2 16
Tlk2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLK2 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tlk2 36
  • 93.56 (n)
  • 99.47 (a)
chicken
(Gallus gallus)
Aves TLK2 36
  • 87.17 (n)
  • 97.02 (a)
TLK2 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLK2 37
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tlk2 36
  • 80.65 (n)
  • 94.88 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.7649 36
tlk2 36
  • 74.06 (n)
  • 85.76 (a)
tlk2 37
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tlk 36
  • 60.88 (n)
  • 64.33 (a)
tlk 37
  • 26 (a)
OneToMany
BcDNA:GH07910 38
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea tlk-1 36
  • 54.08 (n)
  • 51.66 (a)
tlk-1 37
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MPS1 37
  • 16 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.10347 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14850 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.566 37
  • 65 (a)
OneToMany
Species with no ortholog for TLK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLK2 Gene

ENSEMBL:
Gene Tree for TLK2 (if available)
TreeFam:
Gene Tree for TLK2 (if available)

Paralogs for TLK2 Gene

Paralogs for TLK2 Gene

Pseudogenes.org Pseudogenes for TLK2 Gene

genes like me logo Genes that share paralogs with TLK2: view

Variants for TLK2 Gene

Sequence variations from dbSNP and Humsavar for TLK2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9562 -- 62,613,096(+) AAAGG(C/G)ACTAG utr-variant-3-prime
rs15190 -- 62,613,302(+) GTAGG(A/G)AAAAA utr-variant-3-prime
rs737036 -- 62,519,917(+) CACTT(G/T)CGTAG intron-variant
rs737037 -- 62,519,936(+) CCCCT(A/G)TTGTT intron-variant
rs888501 -- 62,504,962(+) cctta(A/G)ccacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLK2 Gene

Variant ID Type Subtype PubMed ID
esv1421317 OTHER Inversion 17803354
nsv516636 CNV Loss 19592680
nsv509664 CNV Insertion 20534489
nsv2114 CNV Insertion 18451855
nsv908680 CNV Loss 21882294

Relevant External Links for TLK2 Gene

HapMap Linkage Disequilibrium report
TLK2
Human Gene Mutation Database (HGMD)
TLK2

Disorders for TLK2 Gene

Relevant External Links for TLK2

Genetic Association Database (GAD)
TLK2
Human Genome Epidemiology (HuGE) Navigator
TLK2
genes like me logo Genes that share disorders with TLK2: view

No data available for UniProtKB/Swiss-Prot for TLK2 Gene

Publications for TLK2 Gene

  1. Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. (PMID: 11470414) Sillje H.H.W. … Nigg E.A. (Curr. Biol. 2001) 3 4 23
  2. cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. (PMID: 9427565) Yamakawa A. … Date T. (Gene 1997) 2 3 4
  3. Mammalian homologues of the plant tousled gene code for cell-cycle- regulated kinases with maximal activities linked to ongoing DNA replication. (PMID: 10523312) Sillje H.H.W. … Nigg E.A. (EMBO J. 1999) 2 3 4
  4. Nuclear localization of protein kinase U-alpha is regulated by 14-3- 3. (PMID: 10455159) Zhang S. … Muslin A.J. (J. Biol. Chem. 1999) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TLK2 Gene

  • Addgene plasmids for TLK2

Sources for TLK2 Gene

Back to Top

Content