TLK1 Gene
protein-coding GIFtS: 61
GCID: GC02M171812
|
|
tousled-like kinase 1
| |
Aliases
for TLK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tousled-Like Kinase 11 2 3 | | Serine Threonine Protein Kinase2 | | KIAA01371 3 | | Serine/Threonine-Protein Kinase Tousled-Like 12 | | PKU-Beta1 | | SNARE Protein Kinase SNAK2 | | EC 2.7.11.13 8 | | EC 2.7.118 | | PKU-BETA1 | | |
Export aliases for TLK1 gene to outside databasesPrevious GC identifers: GC02M169900 GC02M170390 GC02M172051 GC02M171674 GC02M171556 GC02M163735 |
Summaries
for TLK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TLK1:
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatinassembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cellcycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of thisprotein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding differentisoforms have been found for this gene. (provided by RefSeq, Nov 2011)
UniProtKB/Swiss-Prot: TLK1_HUMAN, Q9UKI8Function: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaksduring S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved inchromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assemblywith syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro,phosphorylates histone H3 at 'Ser-10'
Gene Wiki entry for TLK1
|
Genomic Views
for TLK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TLK1 gene promoter:
Pbx1a HNF-1 FOXO3a FOXO3 Sox9 Nkx2-5 FOXO3b HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TLK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1TLK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M171812: view genomic region
(about GC identifiers)
Start:
|
171,847,333 bp from pter |
End:
|
172,087,824 bp from pter |
Size:
|
240,492 bases |
Orientation:
|
minus strand |
|
Proteins
for TLK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TLK1_HUMAN, Q9UKI8 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase tousled-like 1 Size: 766 amino acids; 86700 Da
Cofactor: Magnesium
Subunit: Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B
Subcellular location: Nucleus
Sequence caution: Sequence=AAF03094.1; Type=Erroneous initiation; Sequence=BAA09486.2; Type=Erroneous initiation;
Secondary accessions: B3KR15 B4DX87 Q14150 Q8N591 Q9NYH2 Q9Y4F6Alternative splicing: 5 isoforms: Q9UKI8-1 Q9UKI8-2 Q9UKI8-3 Q9UKI8-4 Q9UKI8-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TLK1: NX_Q9UKI8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKI8
4/13 DME Specific Peptides for TLK1 (Q9UKI8) (see all 13)
TLK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001130026.1 NP_001130027.1 NP_036422.3
ENSEMBL proteins: ENSP00000411099 ENSP00000354089 ENSP00000352810 ENSP00000428113 ENSP00000409222 ENSP00000387313 ENSP00000397910 ENSP00000393165 ENSP00000402165
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TLK1 for ontologies About GeneDecksing
TLK1 Antibody Products:
Assay Products for TLK1: |
Protein
Domains /
Families
for TLK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TLK1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9UKI8ProtoNet protein and cluster: Q9UKI8 UniProtKB/Swiss-Prot: TLK1_HUMAN, Q9UKI8Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for TLK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TLK1_HUMAN, Q9UKI8Function: Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaksduring S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved inchromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assemblywith syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro,phosphorylates histone H3 at 'Ser-10'Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Cell-cycle regulated, maximal activity in S-phase. Inactivated by phosphorylation at Ser-743,potentially by CHEK1 Genatlas biochemistry entry for TLK1:tousled-like kinase 1,nuclear serine/threonine kinase PKU beta,broadly expressed,autophosphorylating and dimerizingcell-cycle regulated displaying maximal activities during S phase,Arabidopsis thaliana homolog
Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLK1 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLK1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TLK1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TLK1:
|
Pathways & Interactions
for TLK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | DNA Damage | | | 2 | Cell Cycle / Checkpoint Control | | | 3 | ATM Pathway | | | 4 | Chks in Checkpoint Regulation | | | 5 | p53 signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TLK1
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TLK1
2 
Cell Signaling Technology (CST) Pathways for TLK1
1  BioSystems Pathway for TLK1
TLK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/12 Interacting proteins for TLK1 (Q9UKI82, 3 ENSP000004110994) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
TLK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TLK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TLK1
1 HMDB Compound for TLK1 About this table
Search CenterWatch for drugs/clinical trials and news about TLK1
|
Transcripts
for TLK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TLK1 gene (3 alternative transcripts): NM_001136554.1 NM_001136555.1 NM_012290.4 Unigene Cluster for TLK1: Tousled-like kinase 1 Hs.596942 [show with all ESTs]Unigene Representative Sequence: NM_01229013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431350(uc010zdn.1 uc002ugp.2) ENST00000360843 ENST00000359766
ENST00000521943 ENST00000434911 ENST00000409443(uc002ugq.2) ENST00000413010
ENST00000478683(uc002ugr.1) ENST00000486857 ENST00000453628 ENST00000470340
ENST00000466220 ENST00000442919(uc002ugn.2 uc002ugo.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLK1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLK1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TLK1 (NM_012290) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLK1 |
Additional cDNA sequence: AF162666.1 AF246219.1 AK090779.1 AK292508.1 AK301857.1 BC032657.1 BX537631.1 D50927.2 Z25421.1 16 DOTS entries: DT.100819754 DT.120966190 DT.92440397 DT.100036676 DT.206786 DT.100819756 DT.87007891 DT.100708826 DT.95230131 DT.120966186 DT.100819748 DT.100819752 DT.120966209 DT.445900 DT.75172579 DT.100880913 24/231 AceView cDNA sequences (see all 231): CB123552 BM147822 BE466676 BM979121 CB119649 AI523163 AI927483 BG779394 AI401317 BU676027 AI423447 AA860690 BQ581713 BM467976 BF032351 AA504521 AI637705 BM561353 AW955088 BE042925 BX497361 Z41091 BQ723732 AI332883
GeneLoc Exon Structure
|
Expression
for TLK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TLK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCAGAAAA
About this image
See TLK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLK1
SOURCE GeneReport for Unigene cluster: Hs.596942
UniProtKB/Swiss-Prot: TLK1_HUMAN, Q9UKI8Tissue specificity: Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletalmuscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined
SABiosciences Custom PCR Arrays for TLK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLK1 |
Orthologs
for TLK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TLK1 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TLK11 |
tousled-like kinase 1 |
86.72(n)
94.99(a) |
|
429024 XM_426581.3 XP_426581.3 |
lizard
(Anolis carolinensis) |
Reptilia |
TLK16 |
-- |
96(a) |
1 ↔ 1 |
GL343353.1(866429-919743) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.223952 |
Xenopus laevis transcribed sequence with strong similarity more |
82.48(n) |
|
BU901114.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
tlk1a6tlk1b6 |
tousled-like kinase 1b |
85(a)82(a) |
1 ↔ many1 ↔ many |
9(3544979-3605958) 6(3693368-3794863) |
fruit fly
(Drosophila melanogaster) |
Insecta |
BcDNA:GH079103 |
protein amino acid phosphorylation protein
kinase |
72(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
tlk-16 |
Serine/threonine-protein kinase tousled-like 1 |
29(a) |
1 → many |
III(9699797-9710184) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TSL6 |
serine/threonine-protein kinase TOUSLED |
36(a) |
1 → many |
5(7097908-7103198) |
rice
(Oryza sativa) |
Liliopsida |
AK111604.12 |
-- |
75.88(n) |
|
AK111604.1 |
ENSEMBL Gene Tree for TLK1 (if available)
TreeFam Gene Tree for TLK1 (if available) |
Paralogs
for TLK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TLK1 gene
- TTK2 TLK22
4 SIMAP similar genes for TLK1 using alignment to 7 protein entries: TLK1_HUMAN (see all proteins):TLK2 STK11 NUAK1 DKFZp564L2416
TLK1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for TLK1
PGOHUM00000258040 PGOHUM00000263188 PGOHUM00000236766
|
Genomic Variants
for TLK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TLK1 (171847333 - 172087824 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TLK1
2 CNVs: 90127 78852
Human Gene Mutation Database (HGMD): TLK1
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TLK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TLK1 for disorders About GeneDecksing
OMIM gene information: 608438
OMIM disorders: --
6  diseases for TLK1: About MalaCardscholangitis breast cancer pneumonia tuberculosis
malaria mycobacterium tuberculosis
Export disorders for TLK1 gene to outside databases
|
Publications
for TLK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TLK1 gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with TLK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. (PubMed id 12660173)1, 2, 3 Groth A....Hansen K. (2003)
- cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal. (PubMed id 9427565)1, 2, 3 Yamakawa A.... Date T. (1997)
- Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases. (PubMed id 11470414)1, 2, 9 Sillje H.H. and Nigg E.A. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed. (PubMed id 11314006)1, 2 Li Y.... De Benedetti A. (2001)
- Mammalian homologues of the plant tousled gene code for cell-cycle- regulated kinases with maximal activities linked to ongoing DNA replication. (PubMed id 10523312)1, 2 Sillje H.H.W.... Nigg E.A. (1999)
- Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly. (PubMed id 10588641)1, 2 Cabaniols J.-P.... Roche P.A. (1999)
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
|
External Searches for TLK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TLK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TLK1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TLK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TLK1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TLK1 gene:
Search GeneIP for patents involving TLK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TLK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TLK1 | | OriGene shRNA RFP for TLK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLK1 | | | OriGene Protein Over-expression Lysate for TLK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TLK1 | | OriGene 3'-UTR Clone for TLK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TLK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TLK1 | | OriGene Custom Protein Services for TLK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLK1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLK1 |
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| | Antibodies & Assays for TLK1
(TLK1 iso1) |
| | | | Search Tocris compounds for TLK1 |
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 | | | TLK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLK1 |
|  |  |  | | | | ThermoFisher Antibodies for TLK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLK1 |
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