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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TLE6 Gene

protein-coding GIFtS: 49
GCID: GC19P002976

transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

Explore 1 disease affiliated with
TLE6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transducin-Like Enhancer Of Split 6 (E(Sp1) Homolog, Drosophila)¹ ²
GRG6¹ ² ⁵
FLJ14009¹
Transducin-Like Enhancer Protein 6²

External Ids:	HGNC: 30788¹	Entrez Gene: 79816²	Ensembl: ENSG00000104953⁷	OMIM: 612399⁵	UniProtKB: Q9H808³

Export aliases for TLE6 gene to outside databases

Previous GC identifers: GC19P002930 GC19P002745

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TLE6_HUMAN, Q9H808

Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress

beyond the first embryonic cell divisions (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TLE6 gene promoter:
USF1 p53 AP-1 ATF-2 USF2 LUN-1 USF-1:USF-2 c-Ets-1 USF-1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLE6 promoter sequence

Search SABiosciences Chromatin IP Primers for TLE6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

TLE6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE6 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P002976: view genomic region (about GC identifiers)

Start:	2,977,444 bp from pter	End:	2,995,182 bp from pter
Size:	17,739 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TLE6_HUMAN, Q9H808 (See protein sequence)

Recommended Name: Transducin-like enhancer protein 6

Size: 449 amino acids; 49827 Da

Subunit: Component of the SCMC which also includes at least OOEP and NLRP5

Subcellular location: Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst

stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By

similarity)

Explore the universe of human proteins at neXtProt for TLE6: NX_Q9H808

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H808

TLE6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001137458.1 NP_079036.1

ENSEMBL proteins:

ENSP00000246112 ENSP00000411783 ENSP00000467126 ENSP00000403096 ENSP00000406893

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	Uscn Proteins for TLE6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005938	cell cortex	--	--
GO:0043234	protein complex	--	--

TLE6 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TLE6 for domains About GeneDecksing

4 InterPro domains/families:

IPR009146 Groucho_enhance

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q9H808

ProtoNet protein and cluster: Q9H808

1 Blocks protein family: IPB009146 Groucho/transducin-like enhancer protein signature

UniProtKB/Swiss-Prot: TLE6_HUMAN, Q9H808

Similarity: Belongs to the WD repeat Groucho/TLE family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TLE6_HUMAN, Q9H808

Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress

beyond the first embryonic cell divisions (By similarity)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TLE6:
		hsa-miR-556-3p
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE6

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

TLE6 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for TLE6

Wnt Signaling Pathway

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TLE6

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/18 Interacting proteins for TLE6 (Q9H808³ ENSP00000246112⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OOEP	A6NGQ2³, ENSP00000359384⁴	STRING: ENSP00000359384 I2D: score=3
NLRP5	P59047³	I2D: score=3
ALX4	Q9H161³	I2D: score=1
CITED4	Q96RK1³	I2D: score=1
EWSR1	Q01844³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

TLE6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TLE6
Search CenterWatch for drugs/clinical trials and news about TLE6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for TLE6 gene (2 alternative transcripts):

NM_001143986.1 NM_024760.2

Unigene Cluster for TLE6:

Transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

Hs.334507 [show with all ESTs]

Unigene Representative Sequence: NM_001143986

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000246112(uc002lwt.2 uc002lwu.2) ENST00000453329 ENST00000482627

ENST00000447920 ENST00000468176 ENST00000452088 ENST00000591953 ENST00000478073

ENST00000474207 ENST00000497878 ENST00000469572

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate TLE6:
		hsa-miR-556-3p
		SwitchGear 3'UTR luciferase reporter plasmid: TLE6 3' UTR sequence

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Additional cDNA sequence:

AK024071.1 BC007215.1 BC007329.2 BC013986.2 BC020206.1 BC068052.1

7 DOTS entries:

DT.40127441 DT.99945082 DT.100751057 DT.100751056 DT.100768196 DT.100845117 DT.121452060

24/55 AceView cDNA sequences (see all 55):

BC013986 BC007329 NM_024760 BM694870 BP357221 BC020206 BX089956 CR590811

AK024071 CR607853 BC068052 BX375734 CB104948 BE208607 BX375733 BX350364

BG437480 AA975026 AU143748 BX361000 BM744758 BM746361 BV176307 BX353668

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TLE6 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^
SP1:																																									-
SP2:													-						-		-		-
SP3:							-						-						-		-		-
SP4:									-				-						-		-		-
SP5:																							-

ExUns:	16	^	17
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TLE6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TLE6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGAGGGAA

About this image

TLE6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TLE6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLE6

SOURCE GeneReport for Unigene cluster: Hs.334507

SABiosciences Custom PCR Arrays for TLE6

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TLE6 gene from 3/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	--	23(a) 22(a)	many ↔ many many ↔ many	GL344313.1(393-18647) GL344313.1(22075-43762)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-42p8.3⁶ tle2⁶	si:dkey-42p8.3 transducin-like enhancer of split 2 (E(sp1) homolo...	18(a) 18(a)	possible ortholog possible ortholog	22(21994430-22077298) 22(21939895-21989606)
fruit fly (Drosophila melanogaster)	Insecta	gro⁶	groucho	19(a)	1 → many	3R(21867432-21875633)

ENSEMBL Gene Tree for TLE6 (if available)
TreeFam Gene Tree for TLE6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TLE6 gene

AES² TLE3² TLE2² TLE4² TLE1²

4 SIMAP similar genes for TLE6 using alignment to 6 protein entries: TLE6_HUMAN (see all proteins):

TLE4 TLE2 TLE1 TLE3

TLE6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs146666733^1,2		--	2975546(+)	`GTTCAA/GGTGAT`	2	--	us2k¹		0	--	--	--	--
rs61542859^1,2	C	--	2975643(+)	`TTTTT-/TGAGAC`	2	--	us2k¹		0	--	--	--	--
rs180725858^1,2		--	2975736(+)	`CCTCCC/TGGGTT`	2	--	us2k¹		0	--	--	--	--
rs34382312^1,2		--	2975745(+)	`TTCACA/GCCATT`	2	--	us2k¹		0	--	--	--	--
rs7260215^1,2	C,A,	--	2975762(+)	`cctcaA/Gcctcc`	2	--	us2k¹		0	--	--	--	--
rs148347128^1,2		--	2975971(+)	`GGTCTC/TGAACC`	2	--	us2k¹		0	--	--	--	--
rs141538157^1,2	C,	--	2976032(+)	`CAGGCA/GTGCAC`	2	--	us2k¹		0	--	--	--	--
rs2052120^1,2	C,F,A,H,	--	2976114(+)	`CTGAGG/AGAGAC`	2	--	us2k¹		24		NS EA NA CSA WA	2526
rs150462796^1,2		--	2976127(+)	`TCCCTA/GGCAGA`	2	--	us2k¹		0	--	--	--	--
rs73512428^1,2	C,	--	2976170(+)	`CCAAAC/GAGAAA`	2	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for TLE6 (2977444 - 2995182 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TLE6
1 CNV: 5070

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLE6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TLE6 for disorders           About GeneDecksing

OMIM gene information: 612399    OMIM disorders: --

1 disease for TLE6:    About MalaCards

neuronitis

Export disorders for TLE6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TLE6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TLE6)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1. (PubMed id 11486032)^{1, 3} Dang J....Look A.T. (2001)
Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. (PubMed id 18551179)¹ Chen P.C....Lipkin S.M. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79816	HGNC: 30788	AceView: FLJ14009	Ensembl:ENSG00000104953	euGenes: HUgn79816
ECgene: TLE6	H-InvDB: TLE6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TLE6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TLE6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TLE6 gene:
Search GeneIP for patents involving TLE6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLE6
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TLE6 gene at Home site.

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TLE6 Gene

transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

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TLE6 Gene

transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

Aliasesfor TLE6 gene

Summariesfor TLE6 gene

Genomic Viewsfor TLE6 gene

Proteinsfor TLE6 gene

Protein Domains /Familiesfor TLE6 gene

Functionfor TLE6 gene

Pathways & Interactionsfor TLE6 gene

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Orthologsfor TLE6 gene

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Genome Databases showing TLE6 gene

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for TLE6 gene

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for TLE6 gene

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