Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLE6 Gene

Aliases for TLE6 Gene

  • Transducin-Like Enhancer Of Split 6 2 3
  • Transducin-Like Enhancer Of Split 6 (E(Sp1) Homolog, Drosophila) 2 3
  • GRG6 3 6
  • Transducin-Like Enhancer Protein 6 3

External Ids for TLE6 Gene

Previous GeneCards Identifiers for TLE6 Gene

  • GC19P002930
  • GC19P002745

Summaries for TLE6 Gene

GeneCards Summary for TLE6 Gene

TLE6 (Transducin-Like Enhancer Of Split 6) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG). An important paralog of this gene is AES.

UniProtKB/Swiss-Prot for TLE6 Gene

  • As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE6 Gene

Genomics for TLE6 Gene

Regulatory Elements for TLE6 Gene

Genomic Location for TLE6 Gene

2,977,446 bp from pter
2,995,184 bp from pter
17,739 bases
Plus strand

Genomic View for TLE6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE6 Gene

Proteins for TLE6 Gene

  • Protein details for TLE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transducin-like enhancer protein 6
    Protein Accession:
    Secondary Accessions:
    • J3KMZ1

    Protein attributes for TLE6 Gene

    572 amino acids
    Molecular mass:
    63473 Da
    Quaternary structure:
    • Component of the SCMC which also includes at least OOEP and NLRP5
    • Sequence=AAH20206.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE6 Gene


neXtProt entry for TLE6 Gene

Proteomics data for TLE6 Gene at MOPED

Post-translational modifications for TLE6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLE6 Gene

No data available for DME Specific Peptides for TLE6 Gene

Domains for TLE6 Gene

Gene Families for TLE6 Gene

  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for TLE6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9H808
  • Contrary to other WD repeat Groucho/TLE family members, does not contain any identifiable Q, GP, CcN or SP domains. Only the C-terminal WD-repeat domain is conserved.
  • Belongs to the WD repeat Groucho/TLE family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with TLE6: view

Function for TLE6 Gene

Molecular function for TLE6 Gene

UniProtKB/Swiss-Prot Function: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

Gene Ontology (GO) - Molecular Function for TLE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TLE6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TLE6 Gene

Localization for TLE6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE6 Gene

Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TLE6 Gene COMPARTMENTS Subcellular localization image for TLE6 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TLE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005938 cell cortex IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with TLE6: view

Pathways for TLE6 Gene

SuperPathways for TLE6 Gene

Superpath Contained pathways
1 Wnt signaling pathway (KEGG)
genes like me logo Genes that share pathways with TLE6: view

Pathways by source for TLE6 Gene

1 R&D Systems pathway for TLE6 Gene

Gene Ontology (GO) - Biological Process for TLE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
GO:0050769 positive regulation of neurogenesis --
genes like me logo Genes that share ontologies with TLE6: view

Transcripts for TLE6 Gene

Unigene Clusters for TLE6 Gene

Transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLE6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^
SP1: -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP7: -
SP9: -

ExUns: 16 ^ 17

Relevant External Links for TLE6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLE6 Gene

mRNA expression in normal human tissues for TLE6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE6 Gene

This gene is overexpressed in Thyroid (4.3).

SOURCE GeneReport for Unigene cluster for TLE6 Gene Hs.334507

genes like me logo Genes that share expressions with TLE6: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for TLE6 Gene

Orthologs for TLE6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLE6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLE6 35
  • 99.07 (n)
  • 98.6 (a)
TLE6 36
  • 98 (a)
(Bos Taurus)
Mammalia LOC511478 35
  • 69.84 (n)
  • 58.1 (a)
TLE6 36
  • 58 (a)
(Canis familiaris)
Mammalia TLE6 35
  • 70.89 (n)
  • 61.27 (a)
TLE6 36
  • 72 (a)
(Mus musculus)
Mammalia Tle6 35
  • 64.53 (n)
  • 52.75 (a)
Tle6 16
Tle6 36
  • 44 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 17 (a)
(Ornithorhynchus anatinus)
Mammalia TLE6 36
  • 5 (a)
(Rattus norvegicus)
Mammalia Tle6 35
  • 65.01 (n)
  • 53.79 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 20 (a)
(Danio rerio)
Actinopterygii si:dkey-42p8.3 36
  • 17 (a)
Species with no ortholog for TLE6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLE6 Gene

Gene Tree for TLE6 (if available)
Gene Tree for TLE6 (if available)

Paralogs for TLE6 Gene

Paralogs for TLE6 Gene

Selected SIMAP similar genes for TLE6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TLE6: view

Variants for TLE6 Gene

Sequence variations from dbSNP and Humsavar for TLE6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs375325 -- 2,992,522(+) TCCCA(C/G)CACTT intron-variant
rs401886 -- 2,994,839(-) CCACC(C/T)GTCAG intron-variant
rs403048 -- 2,994,612(-) TTATT(A/T)TTTTT intron-variant
rs417120 -- 2,978,451(+) TTTTT(A/T)AAAAA intron-variant
rs418667 -- 2,992,165(+) ACCCC(A/G)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE6 Gene

Variant ID Type Subtype PubMed ID
nsv833709 CNV Loss 17160897
nsv910694 CNV Loss 21882294
dgv47n68 CNV Loss 17160897
nsv910695 CNV Loss 21882294

Relevant External Links for TLE6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE6 Gene

Disorders for TLE6 Gene

No disorders were found for TLE6 Gene.

No data available for UniProtKB/Swiss-Prot for TLE6 Gene

Publications for TLE6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1. (PMID: 11486032) Dang J. … Look A.T. (Mol. Cell. Biol. 2001) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for TLE6 Gene

Sources for TLE6 Gene

Back to Top