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Aliases for TLE4 Gene

Aliases for TLE4 Gene

  • Transducin Like Enhancer Of Split 4 2 3 5
  • Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila) 2 3
  • Groucho-Related Protein 4 3 4
  • Grg-4 3 4
  • GRG4 3 4
  • Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1) 3
  • Enhancer Of Split Groucho 4 3
  • B Lymphocyte Gene 1 3
  • KIAA1261 4
  • E(SpI) 3
  • BCE-1 3
  • BCE1 3
  • ESG4 3
  • ESG 3

External Ids for TLE4 Gene

Previous GeneCards Identifiers for TLE4 Gene

  • GC09P073246
  • GC09M074057
  • GC09P075756
  • GC09P077644
  • GC09P077643
  • GC09P079416
  • GC09P081376
  • GC09P082186
  • GC09P052018

Summaries for TLE4 Gene

GeneCards Summary for TLE4 Gene

TLE4 (Transducin Like Enhancer Of Split 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by NOTCH1. GO annotations related to this gene include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot for TLE4 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Gene Wiki entry for TLE4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE4 Gene

Genomics for TLE4 Gene

Regulatory Elements for TLE4 Gene

Promoters for TLE4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLE4 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLE4 Gene

Chromosome:
9
Start:
79,571,773 bp from pter
End:
79,726,882 bp from pter
Size:
155,110 bases
Orientation:
Plus strand

Genomic View for TLE4 Gene

Genes around TLE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE4 Gene

Proteins for TLE4 Gene

  • Protein details for TLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04727-TLE4_HUMAN
    Recommended name:
    Transducin-like enhancer protein 4
    Protein Accession:
    Q04727
    Secondary Accessions:
    • F8W6T6
    • Q3ZCS1
    • Q5T1Y2
    • Q6PCB3
    • Q9BZ07
    • Q9BZ08
    • Q9BZ09
    • Q9NSL3
    • Q9ULF9

    Protein attributes for TLE4 Gene

    Size:
    773 amino acids
    Molecular mass:
    83755 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. Interacts with SIX3 and SIX6 (By similarity). Interacts with PAX2.
    SequenceCaution:
    • Sequence=BAA86575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC22598.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE4 Gene

Proteomics data for TLE4 Gene at MOPED

Post-translational modifications for TLE4 Gene

No data available for DME Specific Peptides for TLE4 Gene

Domains & Families for TLE4 Gene

Gene Families for TLE4 Gene

Graphical View of Domain Structure for InterPro Entry

Q04727

UniProtKB/Swiss-Prot:

TLE4_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
  • Contains 7 WD repeats.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with TLE4: view

Function for TLE4 Gene

Molecular function for TLE4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Gene Ontology (GO) - Molecular Function for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0070491 repressing transcription factor binding IEA --
genes like me logo Genes that share ontologies with TLE4: view
genes like me logo Genes that share phenotypes with TLE4: view

Animal Models for TLE4 Gene

MGI Knock Outs for TLE4:

Animal Model Products

  • Taconic Biosciences Mouse Models for TLE4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE4 Gene

Localization for TLE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLE4 Gene COMPARTMENTS Subcellular localization image for TLE4 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TLE4 Gene

Pathways & Interactions for TLE4 Gene

genes like me logo Genes that share pathways with TLE4: view

Pathways by source for TLE4 Gene

Gene Ontology (GO) - Biological Process for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway TAS --
GO:0008150 biological_process ND --
GO:0016055 Wnt signaling pathway IEA --
GO:1904837 beta-catenin-TCF complex assembly TAS --
genes like me logo Genes that share ontologies with TLE4: view

No data available for SIGNOR curated interactions for TLE4 Gene

Drugs & Compounds for TLE4 Gene

No Compound Related Data Available

Transcripts for TLE4 Gene

Unigene Clusters for TLE4 Gene

Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLE4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TLE4 Gene

GeneLoc Exon Structure for
TLE4
ECgene alternative splicing isoforms for
TLE4

Expression for TLE4 Gene

mRNA expression in normal human tissues for TLE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE4 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for TLE4 Gene

This gene is overexpressed in Testis (27.8), Ovary (24.1), and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLE4 Gene



SOURCE GeneReport for Unigene cluster for TLE4 Gene Hs.444213

mRNA Expression by UniProt/SwissProt for TLE4 Gene

Q04727-TLE4_HUMAN
Tissue specificity: In all tissues examined, mostly in brain, and muscle.
genes like me logo Genes that share expression patterns with TLE4: view

Protein tissue co-expression partners for TLE4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TLE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLE4 35
  • 93.1 (n)
  • 99.35 (a)
TLE4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLE4 35
  • 92.66 (n)
  • 99.21 (a)
TLE4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tle4 35
  • 92.32 (n)
  • 99.61 (a)
Tle4 16
Tle4 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLE4 35
  • 99.5 (n)
  • 99.88 (a)
TLE4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tle4 35
  • 91.72 (n)
  • 99.47 (a)
oppossum
(Monodelphis domestica)
Mammalia TLE4 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLE4 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLE4 35
  • 86.63 (n)
  • 99.35 (a)
TLE4 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLE4 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tle4 35
  • 84 (n)
  • 98.31 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15157 35
zebrafish
(Danio rerio)
Actinopterygii tle2 36
  • 71 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010324 35
  • 60.93 (n)
  • 70.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta gro 36
  • 67 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-37 36
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10712 36
  • 53 (a)
ManyToMany
CSA.8664 36
  • 57 (a)
ManyToMany
Species with no ortholog for TLE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLE4 Gene

ENSEMBL:
Gene Tree for TLE4 (if available)
TreeFam:
Gene Tree for TLE4 (if available)

Paralogs for TLE4 Gene

Paralogs for TLE4 Gene

Pseudogenes.org Pseudogenes for TLE4 Gene

genes like me logo Genes that share paralogs with TLE4: view

Variants for TLE4 Gene

Sequence variations from dbSNP and Humsavar for TLE4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1113107 -- 79,602,539(+) CAAAG(C/T)CTGGG intron-variant
rs1132275 -- 79,725,575(+) taatt(A/G)attta nc-transcript-variant, utr-variant-3-prime
rs1132276 -- 79,725,595(+) TAAGT(A/G)TAGAC nc-transcript-variant, utr-variant-3-prime
rs914715 -- 79,695,983(-) ACCCA(A/T)TAAGA intron-variant
rs1475674 -- 79,671,371(+) GAGCT(C/G)AACGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE4 Gene

Variant ID Type Subtype PubMed ID
nsv831634 CNV Loss 17160897
esv268030 CNV Insertion 20981092
nsv893497 CNV Gain 21882294

Variation tolerance for TLE4 Gene

Residual Variation Intolerance Score: 8.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLE4 Gene

HapMap Linkage Disequilibrium report
TLE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE4 Gene

Disorders for TLE4 Gene

Relevant External Links for TLE4

Genetic Association Database (GAD)
TLE4
Human Genome Epidemiology (HuGE) Navigator
TLE4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLE4

No disorders were found for TLE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE4 Gene

Publications for TLE4 Gene

  1. Mutations in PAX2 associate with adult-onset FSGS. (PMID: 24676634) Barua M. … Pollak M.R. (J. Am. Soc. Nephrol. 2014) 3 4 67
  2. A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes. (PMID: 12153506) Milili M. … Schiff C. (Immunology 2002) 3 23
  3. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PMID: 8365415) Miyasaka H. … Li S.S.-L. (Eur. J. Biochem. 1993) 2 3
  4. The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor. (PMID: 25631048) Abraham S. … Patel S.R. (J. Biol. Chem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TLE4 Gene

Sources for TLE4 Gene

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