Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLE4 Gene

protein-coding   GIFtS: 62
GCID: GC09P082186

Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila)

(Previous names: transducin-like enhancer of split 4, homolog of Drosophila...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila)1 2     ESG42
Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1)1 2     GRG42
BCE-12     B Lymphocyte Gene 12
BCE12     Enhancer Of Split Groucho 42
E(spI)2     Transducin-Like Enhancer Protein 42
ESG2     KIAA12613

External Ids:    HGNC: 118401   Entrez Gene: 70912   Ensembl: ENSG000001068297   OMIM: 6051325   UniProtKB: Q047273   

Export aliases for TLE4 gene to outside databases

Previous GC identifers: GC09P073246 GC09M074057 GC09P075756 GC09P077644 GC09P077643 GC09P079416 GC09P081376 GC09P052018


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TLE4 Gene: 
TLE4 (transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE4 include rabies, and bipolar disorder, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Signaling by GPCR. GO annotations related to this gene include transcription corepressor activity and molecular_function. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects
of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)

Gene Wiki entry for TLE4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLE4 gene promoter:
         TBP   E2F-4   E2F-3a   E2F-5   Sox5   Sp1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLE4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLE4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.31   Ensembl cytogenetic band:  9q21.31   HGNC cytogenetic band: 9q21.32

TLE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P082186:  view genomic region     (about GC identifiers)

Start:
82,186,688 bp from pter      End:
82,341,658 bp from pter
Size:
154,971 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 4  
Size: 773 amino acids; 83755 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.
Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=BAA86575.1; Type=Erroneous initiation; Sequence=CAC22598.1; Type=Erroneous gene model
prediction; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Sequence=CAI13644.1; Type=Erroneous gene
model prediction; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Sequence=CAI41315.1; Type=Erroneous
gene model prediction;
Secondary accessions: Q3ZCS1 Q5T1Y2 Q6PCB3 Q9BZ07 Q9BZ08 Q9BZ09 Q9NSL3 Q9ULF9
Alternative splicing: 3 isoforms:  Q04727-1   Q04727-2   Q04727-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLE4: NX_Q04727

Explore proteomics data for TLE4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. PAX5 binding increases phosphorylation (By similarity)
  • UniProtKB: Ubiquitinated by XIAP/BIRC4
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04727

  • TLE4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLE4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001269677.1  NP_001269678.1  NP_001269682.1  NP_001269689.1  NP_008936.2  

    ENSEMBL proteins: 
     ENSP00000365735   ENSP00000417906   ENSP00000417245   ENSP00000415423   ENSP00000397822  
     ENSP00000365720   ENSP00000417715   ENSP00000265284   ENSP00000412567   ENSP00000409313  
     ENSP00000417844   ENSP00000418409   ENSP00000417102   ENSP00000400334   ENSP00000365727  
     ENSP00000365703   ENSP00000365717  
    Reactome Protein details: Q04727
    Human Recombinant Protein Products for TLE4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TLE4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TLE4
    GenScript Custom Purified and Recombinant Proteins Services for TLE4
    Novus Biologicals TLE4 Protein
    Novus Biologicals TLE4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLE4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1303260
    GO:0005654nucleoplasm TAS--

    TLE4 for ontologies           About GeneDecksing



    TLE4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TLE4
    GenScript Custom Superior Antibodies Services for TLE4
    Novus Biologicals TLE4 Antibodies
    Abcam antibodies for TLE4
    Cloud-Clone Corp. Antibodies for TLE4 
    ThermoFisher Antibody for TLE4
    LSBio Antibodies in human, mouse, rat for TLE4 

    Assay Products for TLE4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TLE4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLE4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLE4 
    Cloud-Clone Corp. CLIAs for TLE4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04727

    ProtoNet protein and cluster: Q04727

    2 Blocks protein domains:
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 7 WD repeats


    TLE4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLE4_HUMAN, Q04727
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
    transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects
    of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003682chromatin binding IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----
         
    TLE4 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Tle4 (no phenotypes)

    TLE4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLE4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLE4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLE4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLE4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TLE4:
    hsa-mir-155 (MIRT005105)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE4
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE4 (see all 76):
    hsa-miR-640 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-1304 hsa-miR-93 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidTLE4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TLE4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TLE4
    Sirion Biotech Customized adenovirus for overexpression of TLE4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TLE4 (see all 8)
    OriGene ORF clones in mouse, rat for TLE4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLE4 (NM_007005)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE4
    Sirion Biotech Customized lentivirus for stable overexpression of TLE4 
                         Customized lentivirus expression plasmids for stable overexpression of TLE4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TLE4
    Search LifeMap BioReagents cell lines for TLE4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLE4 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH0.74
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    2Signaling by GPCR
    Signal Transduction0.55
    3Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway0.54
    4Wnt signaling pathway
    Wnt Signaling Pathway0.40
    5Calcium signaling in the CD4+ TCR pathway
    Calcineurin-regulated NFAT-dependent transcription in lymphocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TLE4
        Development Notch Signaling Pathway

    1 R&D Systems Pathway for TLE4
        Wnt Signaling Pathway


    1 GeneGo (Thomson Reuters) Pathway for TLE4
        Development Notch Signaling Pathway

    2 BioSystems Pathways for TLE4
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    5/11        Reactome Pathways for TLE4 (see all 11)
        NOTCH1 Intracellular Domain Regulates Transcription
    Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer



    TLE4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLE4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/67 Interacting proteins for TLE4 (Q047273 ENSP000003657354) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206305P019093I2D: score=1 
    ENSG00000232062P019093I2D: score=1 
    HLA-DQA1P019093I2D: score=1 
    MSX1P283603, ENSP000003721704I2D: score=1 STRING: ENSP00000372170
    OTX1P322423, ENSP000002825494I2D: score=1 STRING: ENSP00000282549
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007219Notch signaling pathway TAS--
    GO:0008150biological_process ND--
    GO:0016055Wnt receptor signaling pathway IEA--

    TLE4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLE4

    Search CenterWatch for drugs/clinical trials and news about TLE4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLE4 gene (5 alternative transcripts): 
    NM_001282748.1  NM_001282749.1  NM_001282753.1  NM_001282760.1  NM_007005.4  

    Unigene Cluster for TLE4:

    Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
    Hs.444213  [show with all ESTs]
    Unigene Representative Sequence: CR749553
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000376552 ENST00000461758 ENST00000470872 ENST00000435650 ENST00000414465
    ENST00000376537 ENST00000462803 ENST00000376524 ENST00000476523 ENST00000376525
    ENST00000265284 ENST00000425506 ENST00000485159 ENST00000466428 ENST00000428713
    ENST00000455913 ENST00000496853 ENST00000474519
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE4
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE4 (see all 76):
    hsa-miR-640 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-1304 hsa-miR-93 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidTLE4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TLE4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE4
    Clone
    Products:
         
    OriGene clones in human, mouse for TLE4 (see all 8)
    OriGene ORF clones in mouse, rat for TLE4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLE4 (NM_007005)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE4
    Sirion Biotech Customized lentivirus for stable overexpression of TLE4 
                         Customized lentivirus expression plasmids for stable overexpression of TLE4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TLE4
    OriGene qSTAR qPCR primer pairs in human, mouse for TLE4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLE4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE4

    Additional mRNA sequence: 

    AB033087.1 AF068197.1 AK057236.1 AK296342.1 AK302709.1 AL162059.1 BC036369.1 BC045650.1 
    BC059405.1 BC060038.1 BC063695.1 CR749553.1 HQ234317.1 HQ283388.1 M99439.1 

    24/25 DOTS entries (see all 25):

    DT.95207919  DT.408097  DT.40254543  DT.100781090  DT.92444345  DT.100008353  DT.91801736  DT.95207941 
    DT.100691708  DT.100781089  DT.75164612  DT.99930063  DT.99994687  DT.100698012  DT.100814599  DT.121210773 
    DT.95193868  DT.97765326  DT.100670811  DT.100781084  DT.102842859  DT.86842649  DT.91717194  DT.92444346 

    24/210 AceView cDNA sequences (see all 210):

    BQ212204 BC063695 BQ774313 AI140694 AW235513 AL551038 AA213778 NM_007005 
    CA777473 BF434061 BU631235 BM480087 BX099555 AW270135 AW072417 AA779130 
    BM702945 AW295652 CD366183 AK057236 BM673952 CA448873 AL162059 BF438774 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TLE4 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:        -           -                       -                                                                                                               
    SP2:        -           -                       -     -                                                                                                         
    SP3:        -           -                       -     -                                                                                                         
    SP4:                    -                       -     -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TLE4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLE4 expression in normal human tissues (normalized intensities)      TLE4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTAGTTGG
    TLE4 Expression
    About this image


    TLE4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             ganglion/cranial/vagus X   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neural Ectoderm (Nervous System)    fully expand to see all 2 entries
             Spinal Neural Plate Cells Neural Plate
             Neural Plate
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Lymph (Hematopoietic System)
             lymph node   

    See TLE4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLE4

    SOURCE GeneReport for Unigene cluster: Hs.444213

    UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
    Tissue specificity: In all tissues examined, mostly in brain, and muscle

        SABiosciences Custom PCR Arrays for TLE4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TLE4
    OriGene qSTAR qPCR primer pairs in human, mouse for TLE4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLE4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TLE4 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tle41 , 5 transducin-like enhancer of split 4, homolog of Drosophila more1, 5 92.32(n)1
    99.61(a)1
      19 (9.11 cM)5
    218881  NM_011600.21  NP_035730.21 
     144480725 
    chicken
    (Gallus gallus)
    Aves TLE41 transducin-like enhancer of split 4 (E(sp1) homolog, more 86.63(n)
    99.35(a)
      374080  NM_204237.1  NP_989568.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLE46
    Uncharacterized protein
    99(a)
    1 ↔ 1
    2(44577899-44743950)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151572 Xenopus laevis Grg-4 clone mRNA for Groucho family more 81.58(n)    AJ224945.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gro6
    groucho
    65(a)
    1 → many
    3R(21867432-21875633)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-376
    Transcription factor unc-37
    33(a)
    1 → many
    I(6742293-6745341)


    ENSEMBL Gene Tree for TLE4 (if available)
    TreeFam Gene Tree for TLE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLE4 gene
    AES2  TLE32  TLE62  TLE22  TLE12  
    6 SIMAP similar genes for TLE4 using alignment to 15 protein entries:     TLE4_HUMAN (see all proteins):
    TLE1    TLE2    TLE3    AES    GNB5    TLE6

    TLE4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TLE4
    PGOHUM00000241815


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2875 SNPs in TLE4 are shown (see all 2875)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1416866701,2
    --82184903(+) GGATGC/GAGGCG 1 -- us2k10--------
    rs1458352501,2
    --82184921(+) TTGCCG/TAATTG 1 -- us2k10--------
    rs1865280291,2
    --82184962(+) TTAGTA/GTGAAA 1 -- us2k10--------
    rs734572231,2
    C--82184965(+) GTATGA/CAATTA 1 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1913748251,2
    --82185229(+) ACACTA/CTTCTT 1 -- us2k10--------
    rs28073041,2
    C,F,A,H--82185354(-) CTTTCC/TATCCT 1 -- us2k125Minor allele frequency- T:0.29NS EA NA WA CSA 2772
    rs9468061,2
    C,F,H--82185372(-) CGGCCT/CCCGTC 1 -- us2k113Minor allele frequency- C:0.38MN NA WA CSA EA 559
    rs345326881,2
    C,F,H--82185440(+) TCTCTC/TCTCCT 1 -- us2k17Minor allele frequency- T:0.03NS NA 780
    rs1845357891,2
    --82185606(+) CCCAGA/GGCGCG 1 -- us2k10--------
    rs1893702061,2
    --82185745(+) CCACCA/CGGAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLE4 (82186688 - 82341658 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TLE4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv268030CNV Insertion20981092
    nsv831634CNV Loss17160897
    nsv893497CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TLE4
    DNA2.0 Custom Variant and Variant Library Synthesis for TLE4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605132    OMIM disorders: --

    4 diseases for TLE4:    About MalaCards
    rabies    bipolar disorder    asthma    neuronitis


    TLE4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TLE4
    Human Genome Epidemiology (HuGE) Navigator: TLE4 (3 documents)

    Export disorders for TLE4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLE4 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with TLE4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Propensity score-based nonparametric test revealing ge netic variants underlying bipolar disorder. (PubMed id 21254220)1, 4 Jiang Y. and Zhang H. (2011)
    2. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (2010)
    3. Genome-wide association study implicates chromosome 9 q21.31 as a susceptibility locus for asthma in mexican children. (PubMed id 19714205)1, 4 Hancock D.B....London S.J. (2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    6. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3 Miyasaka H.... Li S.S.-L. (1993)
    7. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (1992)
    8. A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes. (PubMed id 12153506)1, 9 Milili M....Schiff C. (2002)
    9. SUMOylated SoxE factors recruit Grg4 and function as t ranscriptional repressors in the neural crest. (PubMed id 22927467)1 Lee P.C....LaBonne C. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7091 HGNC: 11840 AceView: TLE4 Ensembl:ENSG00000106829 euGenes: HUgn7091
    ECgene: TLE4 H-InvDB: TLE4

    (According to HUGE)
    About This Section
    HUGE: KIAA1261

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLE4 gene:
    Search GeneIP for patents involving TLE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TLE4  
     OriGene qPCR primer pairs and template standards for TLE4   OriGene Protein Over-expression Lysate for TLE4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TLE4  
     OriGene qSTAR qPCR primer pairs in human, mouse for TLE4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TLE4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TLE4   OriGene Custom Protein Services for TLE4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLE4
     QIAGEN SeqTarget long-range PCR primers for resequencing TLE4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE4
     GenScript Custom Purified and Recombinant Proteins Services for TLE4 GenScript cDNA clones with any tag delivered in your preferred vector for TLE4
     GenScript Custom Assay Services for TLE4 GenScript Custom Superior Antibodies Services for TLE4
     GenScript Custom overexpressing Cell Line Services for TLE4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TLE4 promoter
     Search Chromatin IP Primers for TLE4
     RT2 qPCR Primer Assay in human, mouse, rat TLE4
     GNC Network for TLE4
     SABiosciences Custom PCR Arrays for TLE4
     Search Tocris compounds for TLE4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TLE4 antibodies
     TLE4 proteins
     TLE4 lysates
     Antibodies for TLE4
     See all of Abcam's Antibodies, Kits and Proteins for TLE4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TLE4
     Antibodies for TLE4
     ELISAs for TLE4
     CLIAs for TLE4
     Search LifeMap BioReagents cell lines for TLE4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE4
     SwitchGear 3'UTR luciferase reporter plasmids for TLE4
     SwitchGear Promoter luciferase reporter plasmids for TLE4
     ThermoFisher Antibody for TLE4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TLE4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLE4
    Customized:
     lentivirus for stable overexpression of TLE4
     lentivirus expression plasmids for stable overexpression of TLE4
     adenovirus for overexpression of TLE4
     LSBio Antibodies in human, mouse, rat for TLE4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TLE4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4