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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLE4 Gene

protein-coding   GIFtS: 59
GCID: GC09P082186

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

(Previous names: transducin-like enhancer of split 4, homolog of Drosophila...)
 Explore 6 diseases affiliated with
TLE4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TLE4    

Aliases
for TLE4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila)1 2     ESG42
E(SpI)1     B Lymphocyte Gene 12
ESG1 2     Enhancer Of Split Groucho 42
GRG41 2     Protein BCE-12
Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1)1 2     Transducin-Like Enhancer Protein 42
BCE-12     KIAA12613
BCE12     

External Ids:    HGNC: 118401   Entrez Gene: 70912   Ensembl: ENSG000001068297   OMIM: 6051325   UniProtKB: Q047273   

Export aliases for TLE4 gene to outside databases

Previous GC identifers: GC09P073246 GC09M074057 GC09P075756 GC09P077644 GC09P077643 GC09P079416 GC09P081376 GC09P052018


Summaries
for TLE4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional
activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE
family members may be modulated by association with dominant-negative AES (By similarity)

Gene Wiki entry for TLE4


Genomic Views
for TLE4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLE4 gene promoter:
         TBP   E2F-4   E2F-3a   E2F-5   Sox5   Sp1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLE4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLE4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.31   Ensembl cytogenetic band:  9q21.31   HGNC cytogenetic band: 9q21.32

TLE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P082186:  view genomic region     (about GC identifiers)

Start:
 82,186,688 bp from pter      End:
 82,341,658 bp from pter
Size:
 154,971 bases      Orientation:
 plus strand

Proteins
for TLE4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 4  
Size: 773 amino acids; 83755 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.
Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=BAA86575.1; Type=Erroneous initiation; Sequence=CAC22598.1; Type=Erroneous gene model
prediction; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Sequence=CAI13644.1; Type=Erroneous gene model
prediction; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Sequence=CAI41315.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q3ZCS1 Q5T1Y2 Q6PCB3 Q9BZ07 Q9BZ08 Q9BZ09 Q9NSL3 Q9ULF9
Alternative splicing: 3 isoforms:  Q04727-1   Q04727-2   Q04727-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLE4: NX_Q04727

Post-translational modifications:

  • Phosphorylated. PAX5 binding increases phosphorylation (By similarity)1
  • Ubiquitinated by XIAP/BIRC41
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04727

    • TLE4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008936.2  
    ENSEMBL proteins: 
     ENSP00000365735   ENSP00000417906   ENSP00000417245   ENSP00000415423   ENSP00000397822  
     ENSP00000365720   ENSP00000417715   ENSP00000265284   ENSP00000412567   ENSP00000409313  
     ENSP00000417844   ENSP00000418409   ENSP00000417102   ENSP00000400334   ENSP00000365727  
     ENSP00000365703   ENSP00000365717  
    Reactome Protein details: Q04727
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: TLE4
    OriGene Custom Protein Services for TLE4 
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    Novus Biologicals TLE4 Protein
    Novus Biologicals TLE4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLE4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1303260
    GO:0005654nucleoplasm TAS--


    TLE4 for ontologies           About GeneDecksing



    TLE4 Antibody Products: 
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    Assay Products for TLE4: 
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    Uscn ELISAs and CLIAs for TLE4

    Protein Domains /
    Families
    for TLE4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLE4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04727

    ProtoNet protein and cluster: Q04727

    2 Blocks protein families:
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 7 WD repeats


    Function
    for TLE4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional
    activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE
    family members may be modulated by association with dominant-negative AES (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target TLE4:
    hsa-mir-155 (MIRT005105)

    OriGene 3'-UTR Clone: TLE4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE4
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE4 (see all 76):
    hsa-miR-640 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-1304 hsa-miR-93 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmid: TLE4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLE4 (see all 7)
    OriGene shRNA RFP: TLE4
    OriGene siRNA: TLE4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TLE4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLE4 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for TLE4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE4

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003682chromatin binding IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----


    TLE4 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI phenotypic allele for Tle4 (no phenotypes)

    TLE4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TLE4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/9 pathways (see all 9)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		FBXW7 Mutants and NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    		Signaling by NOTCH1 in Cancer1.00
    		NOTCH1 Intracellular Domain Regulates Transcription0.65
    2Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    3Disease
    		Disease1.00
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00
    5Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TLE4
        Development Notch Signaling Pathway

    1 R&D Systems Pathway for TLE4
        Wnt Signaling Pathway


    1 GeneGo (Thomson Reuters) Pathway for TLE4
        Development Notch Signaling Pathway

    2 BioSystems Pathways for TLE4 
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    5/11        Reactome Pathways for TLE4 (see all 11)
        NOTCH1 Intracellular Domain Regulates Transcription
    Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer



    TLE4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLE4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/68 Interacting proteins for TLE4 (Q047273 ENSP000003657354) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206305P019093I2D: score=1 
    ENSG00000232062P019093I2D: score=1 
    HLA-DQA1P019093I2D: score=1 
    EIF3CQ996133I2D: score=2 
    EIF3CLQ996133I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007219Notch signaling pathway TAS--
    GO:0008150biological_process ND--


    TLE4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLE4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLE4
    Search CenterWatch for drugs/clinical trials and news about TLE4 

    Transcripts
    for TLE4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLE4 gene: 
    NM_007005.3  

    Unigene Cluster for TLE4:

    Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
    Hs.444213  [show with all ESTs]
    Unigene Representative Sequence: CR749553
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000376552 ENST00000461758 ENST00000470872 ENST00000435650 ENST00000414465
    ENST00000376537 ENST00000462803 ENST00000376524 ENST00000476523 ENST00000376525
    ENST00000265284 ENST00000425506 ENST00000485159 ENST00000466428 ENST00000428713
    ENST00000455913 ENST00000496853 ENST00000474519

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TLE4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE4
    8/76 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE4 (see all 76):
    hsa-miR-640 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-1304 hsa-miR-93 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmid: TLE4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLE4 (see all 7)
    OriGene shRNA RFP: TLE4
    OriGene siRNA: TLE4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE4
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TLE4 (NM_007005)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE4

    Additional cDNA sequence: 

    AB033087.1 AF068197.1 AK057236.1 AK296342.1 AK302709.1 AL162059.1 BC036369.1 BC045650.1 
    BC059405.1 BC060038.1 BC063695.1 CR749553.1 HQ234317.1 HQ283388.1 M99439.1 

    24/25 DOTS entries (see all 25):

    DT.95207919  DT.408097  DT.40254543  DT.100781090  DT.92444345  DT.100008353  DT.91801736  DT.95207941 
    DT.100691708  DT.100781089  DT.75164612  DT.99930063  DT.99994687  DT.100698012  DT.100814599  DT.121210773 
    DT.95193868  DT.97765326  DT.100670811  DT.100781084  DT.102842859  DT.86842649  DT.91717194  DT.92444346 

    24/210 AceView cDNA sequences (see all 210):

    BQ774313 AL551038 AA213778 NM_007005 BM480087 BF434061 BU631235 CA777473 
    BX099555 AI140694 AW235513 AW270135 AW072417 CD366183 AA779130 AW295652 
    BM702945 AL162059 BM673952 AK057236 CA448873 BF438774 AA984747 AW016045 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TLE4 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:        -           -                       -                                                                                                               
    SP2:        -           -                       -     -                                                                                                         
    SP3:        -           -                       -     -                                                                                                         
    SP4:                    -                       -     -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TLE4

    Expression
    for TLE4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLE4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTTAGTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TLE4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural EctodermNeural PlateIsthmus CellsNeural Ectoderm
    BrainCerebral CortexBrain
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Dorsal forebrain-like neurons (Generation of midbra...)Brain

    See TLE4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLE4

    SOURCE GeneReport for Unigene cluster: Hs.444213

    UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
    Tissue specificity: In all tissues examined, mostly in brain, and muscle

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE4

    Orthologs
    for TLE4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLE4 gene from 4/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TLE41 transducin-like enhancer of split 4 (E(sp1) homolog, more 86.63(n)
    99.35(a)    		   374080  NM_204237.1  NP_989568.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TLE46
    		 --
    		 99(a)
    		 1 ↔ 1
    		 2(44577899-44743950)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.151572 Xenopus laevis Grg-4 clone mRNA for Groucho family more 81.58(n)    AJ224945.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta gro6
    		 groucho
    		 63(a)
    		 1 → many
    		 3R(21867432-21875633)


    ENSEMBL Gene Tree for TLE4 (if available)
    TreeFam Gene Tree for TLE4 (if available) 

    Paralogs
    for TLE4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLE4 gene
    AES2  TLE32  TLE62  TLE22  TLE12  
    6 SIMAP similar genes for TLE4 using alignment to 15 protein entries:     TLE4_HUMAN (see all proteins):
    TLE1    TLE2    TLE3    AES    GNB5    TLE6

    TLE4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TLE4
    PGOHUM00000241815


    Genomic Variants
    for TLE4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2353 NCBI SNPs in TLE4 are shown (see all 2353)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1416866701,2
    		--82184903(+) GGATGC/GAGGCG 1 -- us2k10--------
    rs1458352501,2
    		--82184921(+) TTGCCG/TAATTG 1 -- us2k10--------
    rs1865280291,2
    		--82184962(+) TTAGTA/GTGAAA 1 -- us2k10--------
    rs734572231,2
    		C,--82184965(+) GTATGA/CAATTA 1 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1913748251,2
    		--82185229(+) ACACTA/CTTCTT 1 -- us2k10--------
    rs28073041,2
    		C,F,A,H,--82185354(-) CTTTCC/TATCCT 1 -- us2k125Minor allele frequency- T:0.29NS EA NA WA CSA 2772
    rs9468061,2
    		C,F,H,--82185372(-) CGGCCT/CCCGTC 1 -- us2k113Minor allele frequency- C:0.38MN NA WA CSA EA 559
    rs345326881,2
    		C,F,H,--82185440(+) TCTCTC/TCTCCT 1 -- us2k17Minor allele frequency- T:0.03NS NA 780
    rs1845357891,2
    		--82185606(+) CCCAGA/GGCGCG 1 -- us2k10--------
    rs1893702061,2
    		--82185745(+) CCACCA/CGGAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLE4 (82186688 - 82341658 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TLE4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLE4
    DNA2.0 Custom Variant and Variant Library Synthesis for TLE4

    Disorders / Diseases
    for TLE4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLE4 for disorders           About GeneDecksing

    OMIM gene information: 605132    OMIM disorders: --

    6 diseases for TLE4:    About MalaCards
    pituitary carcinoma    rabies    asthma    obesity
    neuronitis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: TLE4 (3 documents)

    Export disorders for TLE4 gene to outside databases

    Publications
    for TLE4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLE4 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TLE4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    3. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3 Miyasaka H.... Li S.S.-L. (1993)
    4. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (1992)
    5. A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes. (PubMed id 12153506)1, 9 Milili M....Schiff C. (2002)
    6. SUMOylated SoxE factors recruit Grg4 and function as t ranscriptional repressors in the neural crest. (PubMed id 22927467)1 Lee P.C....LaBonne C. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. (PubMed id 22304967)2 Hanson A.J....Lee E. (2012)
    9. Epigenetic mechanisms of Groucho/Grg/TLE mediated tran scriptional repression. (PubMed id 22169276)1 Patel S.R....Dressler G.R. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for TLE4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing TLE4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7091 HGNC: 11840 AceView: TLE4 Ensembl:ENSG00000106829 euGenes: HUgn7091
    ECgene: TLE4 H-InvDB: TLE4

    Other Databases showing TLE4 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1261

    Specialized Databases showing TLE4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLE4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TLE4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLE4 gene:
    Search GeneIP for patents involving TLE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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