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Aliases for TLE4 Gene

Aliases for TLE4 Gene

  • Transducin Like Enhancer Of Split 4 2 3 5
  • Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila) 2 3
  • Groucho-Related Protein 4 3 4
  • Grg-4 3 4
  • GRG4 3 4
  • Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1) 3
  • Transducin-Like Enhancer Protein 4 3
  • Enhancer Of Split Groucho 4 3
  • B Lymphocyte Gene 1 3
  • KIAA1261 4
  • E(SpI) 3
  • BCE-1 3
  • BCE1 3
  • ESG4 3
  • ESG 3

External Ids for TLE4 Gene

Previous GeneCards Identifiers for TLE4 Gene

  • GC09P073246
  • GC09M074057
  • GC09P075756
  • GC09P077644
  • GC09P077643
  • GC09P079416
  • GC09P081376
  • GC09P082186
  • GC09P052018

Summaries for TLE4 Gene

GeneCards Summary for TLE4 Gene

TLE4 (Transducin Like Enhancer Of Split 4) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TLE1.

UniProtKB/Swiss-Prot for TLE4 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Gene Wiki entry for TLE4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE4 Gene

Genomics for TLE4 Gene

Regulatory Elements for TLE4 Gene

Enhancers for TLE4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G079609 3.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 20.2 +39.2 39212 3.6 SIN3A FEZF1 BRCA1 RAD21 ETV6 IKZF2 CREM EGR2 CEBPB JUNB TLE4 GC09P079610 GC09P079662
GH09G079629 2 VISTA ENCODE 11.3 +59.1 59092 2.0 TBL1XR1 BACH1 BMI1 RELA ARID3A EED RELB IKZF2 MTA2 BHLHE40 TLE4 GC09P079610 GC09P079662
GH09G079659 1.7 VISTA Ensembl ENCODE dbSUPER 11.6 +90.2 90156 5.2 MXI1 RAD21 GATA3 SCRT2 PRDM10 TCF7L2 EZH2 SCRT1 RFX1 EP300 TLE4 GC09P079662 GC09P079610
GH09G079692 1.2 Ensembl ENCODE dbSUPER 15.7 +122.2 122227 3.9 RFX1 MTA2 TEAD4 EBF1 CHD7 BRCA1 TBX21 CTBP1 GATA3 RAD51 TLE4 ENSG00000240979 GC09P079663
GH09G079623 1.4 Ensembl ENCODE dbSUPER 12 +52.6 52601 1.3 HDGF PKNOX1 WRNIP1 ZBTB40 EGR1 CBX5 FOS RELB ETV6 IKZF2 TLE4 GC09P079610 GC09P079662
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLE4 on UCSC Golden Path with GeneCards custom track

Promoters for TLE4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000236512 827 4801 HDGF HNRNPUL1 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 ZNF143 FOS

Genomic Location for TLE4 Gene

Chromosome:
9
Start:
79,571,773 bp from pter
End:
79,726,882 bp from pter
Size:
155,110 bases
Orientation:
Plus strand

Genomic View for TLE4 Gene

Genes around TLE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE4 Gene

Proteins for TLE4 Gene

  • Protein details for TLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04727-TLE4_HUMAN
    Recommended name:
    Transducin-like enhancer protein 4
    Protein Accession:
    Q04727
    Secondary Accessions:
    • F8W6T6
    • Q3ZCS1
    • Q5T1Y2
    • Q6PCB3
    • Q9BZ07
    • Q9BZ08
    • Q9BZ09
    • Q9NSL3
    • Q9ULF9

    Protein attributes for TLE4 Gene

    Size:
    773 amino acids
    Molecular mass:
    83755 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. Interacts with SIX3 and SIX6 (By similarity). Interacts with PAX2.
    SequenceCaution:
    • Sequence=BAA86575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC22598.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE4 Gene

Post-translational modifications for TLE4 Gene

No data available for DME Specific Peptides for TLE4 Gene

Domains & Families for TLE4 Gene

Gene Families for TLE4 Gene

Graphical View of Domain Structure for InterPro Entry

Q04727

UniProtKB/Swiss-Prot:

TLE4_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE4: view

Function for TLE4 Gene

Molecular function for TLE4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Gene Ontology (GO) - Molecular Function for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003682 chromatin binding IEA --
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 24676634
genes like me logo Genes that share ontologies with TLE4: view
genes like me logo Genes that share phenotypes with TLE4: view

Animal Models for TLE4 Gene

MGI Knock Outs for TLE4:

Animal Model Products

  • Taconic Biosciences Mouse Models for TLE4

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE4 Gene

Localization for TLE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1303260
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with TLE4: view

Pathways & Interactions for TLE4 Gene

genes like me logo Genes that share pathways with TLE4: view

Gene Ontology (GO) - Biological Process for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TLE4: view

No data available for SIGNOR curated interactions for TLE4 Gene

Drugs & Compounds for TLE4 Gene

No Compound Related Data Available

Transcripts for TLE4 Gene

Unigene Clusters for TLE4 Gene

Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLE4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TLE4 Gene

GeneLoc Exon Structure for
TLE4
ECgene alternative splicing isoforms for
TLE4

Expression for TLE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE4 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for TLE4 Gene

This gene is overexpressed in Testis (27.8), Ovary (24.1), and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLE4 Gene



Protein tissue co-expression partners for TLE4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLE4 Gene:

TLE4

SOURCE GeneReport for Unigene cluster for TLE4 Gene:

Hs.444213

mRNA Expression by UniProt/SwissProt for TLE4 Gene:

Q04727-TLE4_HUMAN
Tissue specificity: In all tissues examined, mostly in brain, and muscle.

Evidence on tissue expression from TISSUES for TLE4 Gene

  • Nervous system(4.7)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TLE4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE4 Gene

Orthologs for TLE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLE4 34 35
  • 99.5 (n)
oppossum
(Monodelphis domestica)
Mammalia TLE4 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLE4 34 35
  • 93.1 (n)
dog
(Canis familiaris)
Mammalia TLE4 34 35
  • 92.66 (n)
mouse
(Mus musculus)
Mammalia Tle4 34 16 35
  • 92.32 (n)
rat
(Rattus norvegicus)
Mammalia Tle4 34
  • 91.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TLE4 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLE4 34 35
  • 86.63 (n)
lizard
(Anolis carolinensis)
Reptilia TLE4 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tle4 34
  • 84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15157 34
zebrafish
(Danio rerio)
Actinopterygii tle2 35
  • 71 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta gro 35
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010324 34
  • 60.93 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-37 35
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8664 35
  • 57 (a)
ManyToMany
CSA.10712 35
  • 53 (a)
ManyToMany
Species where no ortholog for TLE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLE4 Gene

ENSEMBL:
Gene Tree for TLE4 (if available)
TreeFam:
Gene Tree for TLE4 (if available)

Paralogs for TLE4 Gene

Paralogs for TLE4 Gene

Pseudogenes.org Pseudogenes for TLE4 Gene

genes like me logo Genes that share paralogs with TLE4: view

Variants for TLE4 Gene

Sequence variations from dbSNP and Humsavar for TLE4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000018449 -- 79,701,962(+) GGAAC(A/G)AAGAG intron-variant
rs1000025647 -- 79,652,253(+) ACGAA(C/G)TCGGC intron-variant
rs1000069629 -- 79,624,075(+) TGGAA(G/T)ACAAG intron-variant
rs1000083736 -- 79,617,226(+) CCACA(C/T)AGGTT intron-variant
rs1000126914 -- 79,584,252(+) CCAAG(A/T)GTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE4 Gene

Variant ID Type Subtype PubMed ID
esv3450741 CNV insertion 20981092
nsv1048899 CNV gain 25217958
nsv831634 CNV loss 17160897

Variation tolerance for TLE4 Gene

Residual Variation Intolerance Score: 8.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE4 Gene

Disorders for TLE4 Gene

Relevant External Links for TLE4

Genetic Association Database (GAD)
TLE4
Human Genome Epidemiology (HuGE) Navigator
TLE4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLE4

No disorders were found for TLE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE4 Gene

Publications for TLE4 Gene

  1. Mutations in PAX2 associate with adult-onset FSGS. (PMID: 24676634) Barua M. … Pollak M.R. (J. Am. Soc. Nephrol. 2014) 3 4 64
  2. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y. … Zhang H. (Genet. Epidemiol. 2011) 3 46 64
  3. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) MelAcn E. … Lasky-Su J. (J. Allergy Clin. Immunol. 2010) 3 46 64
  4. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. (PMID: 19714205) Hancock D.B. … London S.J. (PLoS Genet. 2009) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TLE4 Gene

Sources for TLE4 Gene

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