Aliases for TLE4 Gene
External Ids for TLE4 Gene
Previous GeneCards Identifiers for TLE4 Gene
GeneCards Summary for TLE4 Gene
TLE4 (Transducin Like Enhancer Of Split 4) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TLE1.
UniProtKB/Swiss-Prot for TLE4 Gene
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).