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TLE4 Gene

protein-coding   GIFtS: 62
GCID: GC09P082186

Transducin-Like Enhancer Of Split 4

(Previous names: transducin-like enhancer of split 4, homolog of Drosophila...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transducin-Like Enhancer Of Split 41 2     ESG42
Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila)1 2     GRG42
Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1)1 2     B Lymphocyte Gene 12
BCE-12     Enhancer Of Split Groucho 42
BCE12     Transducin-Like Enhancer Protein 42
E(spI)2     KIAA12613
ESG2     

External Ids:    HGNC: 118401   Entrez Gene: 70912   Ensembl: ENSG000001068297   OMIM: 6051325   UniProtKB: Q047273   

Export aliases for TLE4 gene to outside databases

Previous GC identifers: GC09P073246 GC09M074057 GC09P075756 GC09P077644 GC09P077643 GC09P079416 GC09P081376 GC09P052018


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TLE4 Gene:
TLE4 (transducin-like enhancer of split 4) is a protein-coding gene. GO annotations related to this gene include chromatin binding and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects
of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)

Gene Wiki entry for TLE4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLE4 gene promoter:
         TBP   E2F-4   E2F-3a   E2F-5   Sox5   Sp1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLE4 promoter sequence
   Search Chromatin IP Primers for TLE4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.31   Ensembl cytogenetic band:  9q21.31   HGNC cytogenetic band: 9q21.32

TLE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P082186:  view genomic region     (about GC identifiers)

Start:
82,186,688 bp from pter      End:
82,341,658 bp from pter
Size:
154,971 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 4  
Size: 773 amino acids; 83755 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.
Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression (By similarity)
Sequence caution: Sequence=BAA86575.1; Type=Erroneous initiation; Sequence=CAC22598.1; Type=Erroneous gene model
prediction; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Sequence=CAI13644.1; Type=Erroneous gene
model prediction; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Sequence=CAI41315.1; Type=Erroneous
gene model prediction;
Secondary accessions: Q3ZCS1 Q5T1Y2 Q6PCB3 Q9BZ07 Q9BZ08 Q9BZ09 Q9NSL3 Q9ULF9
Alternative splicing: 3 isoforms:  Q04727-1   Q04727-2   Q04727-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLE4: NX_Q04727

Explore proteomics data for TLE4 at MOPED

Post-translational modifications: 

  • Phosphorylated. PAX5 binding increases phosphorylation (By similarity)1
  • Ubiquitinated by XIAP/BIRC41
  • Ubiquitination2 at Lys36, Lys721
  • Modification sites at PhosphoSitePlus

  • See TLE4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001269677.1  NP_001269678.1  NP_001269682.1  NP_001269689.1  NP_008936.2  

    ENSEMBL proteins: 
     ENSP00000365735   ENSP00000417906   ENSP00000417245   ENSP00000415423   ENSP00000397822  
     ENSP00000365720   ENSP00000417715   ENSP00000265284   ENSP00000412567   ENSP00000409313  
     ENSP00000417844   ENSP00000418409   ENSP00000417102   ENSP00000400334   ENSP00000365727  
     ENSP00000365703   ENSP00000365717  
    Reactome Protein details: Q04727

    TLE4 Human Recombinant Protein Products:

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    Novus Biologicals TLE4 Protein
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    Cloud-Clone Corp. Proteins for TLE4

     
    Search eBioscience for Proteins for TLE4 

    TLE4 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04727

    ProtoNet protein and cluster: Q04727

    2 Blocks protein domains:
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with TLE4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLE4_HUMAN, Q04727
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
    transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects
    of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003682chromatin binding IEA--
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TLE4           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Tle4 (no phenotypes)

    Find genes that share phenotypes with TLE4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLE4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLE4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLE4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TLE4:
    hsa-mir-26b-5p (MIRT029323), hsa-mir-193b-3p (MIRT041429), hsa-mir-155-5p (MIRT005105), hsa-let-7d-5p (MIRT032123), hsa-mir-548b-3p (MIRT016236), hsa-mir-186-5p (MIRT021114), hsa-mir-16-5p (MIRT031643), hsa-mir-103a-3p (MIRT027063), hsa-mir-221-3p (MIRT046892), hsa-mir-335-5p (MIRT017745)

    Block miRNA regulation of human, mouse, rat TLE4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLE4 (see all 76):
    hsa-miR-640 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-1304 hsa-miR-93 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidTLE4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TLE4
    Predesigned siRNA for gene silencing in human, mouse, rat TLE4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TLE4 (NM_007005)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE4

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLE4_HUMAN, Q04727: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1303260
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with TLE4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLE4 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.64
    2Signaling by GPCR
    Signal Transduction0.58
    3Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50
    4Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40
    5Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Find genes that share SuperPaths with TLE4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TLE4
        Wnt Signaling Pathways


    1 GeneGo (Thomson Reuters) Pathway for TLE4
        Development Notch Signaling Pathway

    1 BioSystems Pathway for TLE4
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    3 Reactome Pathways for TLE4
        NOTCH1 Intracellular Domain Regulates Transcription
    deactivation of the beta-catenin transactivating complex
    formation of the beta-catenin:TCF transactivating complex


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TLE4
    Interactions:

        GeneGlobe Interaction Network for TLE4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLE4 (Q047273 ENSP000003657354) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206305P019093I2D: score=1 
    ENSG00000232062P019093I2D: score=1 
    HLA-DQA1P019093I2D: score=1 
    SIX3O953433, ENSP000002606534I2D: score=4 STRING: ENSP00000260653
    SIX6O954753, ENSP000003285964I2D: score=4 STRING: ENSP00000328596
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007219Notch signaling pathway TAS--
    GO:0008150biological_process ND--
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with TLE4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLE4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLE4 gene (5 alternative transcripts): 
    NM_001282748.1  NM_001282749.1  NM_001282753.1  NM_001282760.1  NM_007005.4  

    Unigene Cluster for TLE4:

    Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
    Hs.444213  [show with all ESTs]
    Unigene Representative Sequence: CR749553
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000376552 ENST00000461758 ENST00000470872 ENST00000435650 ENST00000414465
    ENST00000376537 ENST00000462803 ENST00000376524 ENST00000476523 ENST00000376525
    ENST00000265284 ENST00000425506 ENST00000485159 ENST00000466428 ENST00000428713
    ENST00000455913 ENST00000496853 ENST00000474519
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TLE4 (see all 76):
    hsa-miR-640 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-1304 hsa-miR-93 hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidTLE4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLE4
    Clone
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    OriGene clones in human, mouse for TLE4 (see all 8)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLE4 (NM_007005)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE4
    Primer
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    OriGene qPCR primer pairs and template standards for TLE4
    OriGene qSTAR qPCR primer pairs in human, mouse for TLE4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLE4
      QuantiTect SYBR Green Assays in human, mouse, rat TLE4
      QuantiFast Probe-based Assays in human, mouse, rat TLE4

    Additional mRNA sequence: 

    AB033087.1 AF068197.1 AK057236.1 AK296342.1 AK302709.1 AL162059.1 BC036369.1 BC045650.1 
    BC059405.1 BC060038.1 BC063695.1 CR749553.1 HQ234317.1 HQ283388.1 M99439.1 

    Selected DOTS entries (see all 25):

    DT.95207919  DT.408097  DT.40254543  DT.100781090  DT.92444345  DT.100008353  DT.91801736  DT.95207941 
    DT.100691708  DT.100781089  DT.75164612  DT.99930063  DT.99994687  DT.100698012  DT.100814599  DT.121210773 
    DT.95193868  DT.97765326  DT.100670811  DT.100781084  DT.102842859  DT.86842649  DT.91717194  DT.92444346 

    Selected AceView cDNA sequences (see all 210):

    BQ212204 BC063695 BQ774313 AI140694 AW235513 AL551038 AA213778 NM_007005 
    CA777473 BF434061 BU631235 BM480087 BX099555 AW270135 AW072417 AA779130 
    BM702945 AW295652 CD366183 AK057236 BM673952 CA448873 AL162059 BF438774 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TLE4 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:        -           -                       -                                                                                                               
    SP2:        -           -                       -     -                                                                                                         
    SP3:        -           -                       -     -                                                                                                         
    SP4:                    -                       -     -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 20
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TLE4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLE4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTAGTTGG
    TLE4 Expression
    About this image


    TLE4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neural Ectoderm (Nervous System)    fully expand to see all 2 entries
             Spinal Neural Plate Cells Neural Plate
             Neural Plate
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TLE4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLE4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444213

    UniProtKB/Swiss-Prot: TLE4_HUMAN, Q04727
    Tissue specificity: In all tissues examined, mostly in brain, and muscle

        Custom PCR Arrays for TLE4
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    QuantiFast Probe-based Assays in human, mouse, rat TLE4
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLE4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tle41 , 5 transducin-like enhancer of split 4, homolog of Drosophila more1, 5 92.32(n)1
    99.61(a)1
      19 (9.11 cM)5
    218881  NM_011600.21  NP_035730.21 
     144480725 
    chicken
    (Gallus gallus)
    Aves TLE41 transducin-like enhancer of split 4 (E(sp1) homolog, more 86.63(n)
    99.35(a)
      374080  NM_204237.1  NP_989568.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLE46
    transducin-like enhancer of split 4 (E(sp1) homolo...
    99(a)
    1 ↔ 1
    2(44577899-44743950)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151572 Xenopus laevis Grg-4 clone mRNA for Groucho family more 81.58(n)    AJ224945.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tle26
    transducin-like enhancer of split 2 (E(sp1) homolo...
    71(a)
    many ↔ many
    22(21939895-21989606) ENSDARG00000042484
    fruit fly
    (Drosophila melanogaster)
    Insecta gro6
    groucho
    67(a)
    1 → many
    3R(21867432-21875633)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-376
    Protein UNC-37 (unc-37) mRNA, complete cds
    41(a)
    1 ↔ 1
    I(6742293-6745341) WBGene00006773


    ENSEMBL Gene Tree for TLE4 (if available)
    TreeFam Gene Tree for TLE4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLE4 gene
    AES2  TLE32  TLE62  TLE22  TLE12  
    6 SIMAP similar genes for TLE4 using alignment to 15 protein entries:     TLE4_HUMAN (see all proteins):
    TLE1    TLE2    TLE3    AES    GNB5    TLE6

    Find genes that share paralogs with TLE4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TLE4
    PGOHUM00000241815


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLE4 (see all 2875)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1416866701,2
    --82184903(+) GGATGC/GAGGCG 1 -- us2k10--------
    rs1458352501,2
    --82184921(+) TTGCCG/TAATTG 1 -- us2k10--------
    rs1865280291,2
    --82184962(+) TTAGTA/GTGAAA 1 -- us2k10--------
    rs734572231,2
    C--82184965(+) GTATGA/CAATTA 1 -- us2k12Minor allele frequency- C:0.10WA 120
    rs1913748251,2
    --82185229(+) ACACTA/CTTCTT 1 -- us2k10--------
    rs28073041,2
    C,F,A,H--82185354(-) CTTTCC/TATCCT 1 -- us2k125Minor allele frequency- T:0.29NS EA NA WA CSA 2772
    rs9468061,2
    C,F,H--82185372(-) CGGCCT/CCCGTC 1 -- us2k113Minor allele frequency- C:0.38MN NA WA CSA EA 559
    rs345326881,2
    C,F,H--82185440(+) TCTCTC/TCTCCT 1 -- us2k17Minor allele frequency- T:0.03NS NA 780
    rs1845357891,2
    --82185606(+) CCCAGA/GGCGCG 1 -- us2k10--------
    rs1893702061,2
    --82185745(+) CCACCA/CGGAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TLE4 (82186688 - 82341658 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TLE4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268030CNV Insertion20981092
    nsv831634CNV Loss17160897
    nsv893497CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLE4
    DNA2.0 Custom Variant and Variant Library Synthesis for TLE4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605132    OMIM disorders: --


    Find genes that share disorders with TLE4           About GenesLikeMe

    Genetic Association Database (GAD): TLE4
    Human Genome Epidemiology (HuGE) Navigator: TLE4 (3 documents)

    Export disorders for TLE4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLE4 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with TLE4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PubMed id 21254220)1, 4 Jiang Y. and Zhang H. (Genet. Epidemiol. 2011)
    2. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    3. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. (PubMed id 19714205)1, 4 Hancock D.B....London S.J. (PLoS Genet. 2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    6. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3 Miyasaka H.... Li S.S.-L. (Eur. J. Biochem. 1993)
    7. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (Nat. Genet. 1992)
    8. A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes. (PubMed id 12153506)1, 9 Milili M....Schiff C. (Immunology 2002)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest. (PubMed id 22927467)1 Lee P.C....LaBonne C. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7091 HGNC: 11840 AceView: TLE4 Ensembl:ENSG00000106829 euGenes: HUgn7091
    ECgene: TLE4 H-InvDB: TLE4

    (According to HUGE)
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    HUGE: KIAA1261

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLE4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLE4 gene:
    Search GeneIP for patents involving TLE4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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