TLE3 Gene
protein-coding GIFtS: 59
GCID: GC15M070341
|
|
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)(Previous names: transducin-like enhancer of split 3, homolog of Drosophila...)
| |
Aliases
for TLE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila)1 2 | | Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1)1 2 | | ESG31 2 3 | | KIAA15471 3 | | ESG1 2 5 | | Enhancer Of Split Groucho-Like Protein 32 3 | | GRG31 2 | | Enhancer Of Split Groucho 32 | | HsT189761 2 | | Transducin-Like Enhancer Protein 32 |
Export aliases for TLE3 gene to outside databasesPrevious GC identifers: GC15M066130 GC15M063439 GC15M067919 GC15M068057 GC15M068129 GC15M047172 |
Summaries
for TLE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptionalactivation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family membersmay be modulated by association with dominant-negative AES (By similarity)
Gene Wiki entry for TLE3
|
Genomic Views
for TLE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TLE3 gene promoter:
Egr-3 GATA-1 CBF-C C/EBPalpha MZF-1 CBF-B CBF-A HSF2 CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TLE3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q22TLE3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M070341: view genomic region
(about GC identifiers)
Start:
|
70,340,129 bp from pter |
End:
|
70,390,515 bp from pter |
Size:
|
50,387 bases |
Orientation:
|
minus strand |
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Proteins
for TLE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726 (See
protein sequence)Recommended Name: Transducin-like enhancer protein 3 Size: 772 amino acids; 83417 Da
Subunit: Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). BindsFOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4
Subcellular location: Nucleus
Sequence caution: Sequence=BAB13373.1; Type=Erroneous initiation;
Secondary accessions: E9PD64 Q8IVV6 Q8WVR2 Q9HCM5Alternative splicing: 5 isoforms: Q04726-1 Q04726-2 Q04726-3 Q04726-4 Q04726-5 (No experimental confirmation available. Contains a N6-acetyllysine at position 343)Explore the universe of human proteins at neXtProt for TLE3: NX_Q04726
Post-translational modifications:
Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity totetramerize but inhibits its interaction with TCF7L2/TCF41
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q04726
TLE3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001098662.1 NP_005069.2 NP_065959.1
ENSEMBL proteins: ENSP00000452871 ENSP00000319233 ENSP00000452803 ENSP00000453219 ENSP00000454141 ENSP00000453081 ENSP00000453760 ENSP00000452933 ENSP00000453083 ENSP00000453373 ENSP00000442594 ENSP00000452881 ENSP00000415057 ENSP00000454029 ENSP00000453107 ENSP00000453435 ENSP00000394717 ENSP00000452809 ENSP00000457641 ENSP00000456178 ENSP00000390007 Reactome Protein details: Q04726
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TLE3 for ontologies About GeneDecksing
TLE3 Antibody Products:
Assay Products for TLE3: |
Protein
Domains /
Families
for TLE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TLE3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q04726ProtoNet protein and cluster: Q04726 3 Blocks protein families: IPB001680 G-protein beta WD-40 repeat signature IPB005617 Groucho/TLE N-terminal Q-rich domain IPB009146 Groucho/transducin-like enhancer protein signature
UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726Similarity: Belongs to the WD repeat Groucho/TLE familySimilarity: Contains 7 WD repeats |
Function
for TLE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptionalactivation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family membersmay be modulated by association with dominant-negative AES (By similarity) Genatlas biochemistry entry for TLE3:transducin-like enhancer of split 3,with homology to Drosophila split Groucho (Notch signaling pathway)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLE3 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLE3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TLE3 (NM_005078) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLE3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
TLE3 for ontologies About GeneDecksing
Animal Models:
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tle3):
TLE3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TLE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant | | | 2 | Development_Notch Signaling Pathway | | | 3 | Disease | | | 4 | Nanog in Mammalian ESC Pluripotency | | | 5 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TLE3
1  R&D Systems Pathway for TLE3
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TLE3
1  GeneGo (Thomson Reuters) Pathway for TLE3
5/11 
Reactome Pathways for TLE3 (see all 11)
TLE3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLE3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/36 Interacting proteins for TLE3 (Q047262, 3 ENSP000003192334) via UniProtKB, MINT, STRING, and/or I2D (see all 36)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
TLE3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TLE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TLE3
Search CenterWatch for drugs/clinical trials and news about TLE3
|
Transcripts
for TLE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TLE3 gene (3 alternative transcripts): NM_001105192.1 NM_005078.2 NM_020908.1 Unigene Cluster for TLE3: Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) Hs.287362 [show with all ESTs]Unigene Representative Sequence: NM_00507818/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26): ENST00000558939(uc002ask.2 uc002asl.2 uc010ukd.1 uc010bil.1 uc002asn.2 uc002asm.2 uc002asp.2 uc002aso.2)
ENST00000317509 ENST00000557919 ENST00000560525 ENST00000557815 ENST00000560589
ENST00000559929 ENST00000559048 ENST00000560939 ENST00000557997 ENST00000561453
ENST00000559608 ENST00000539550 ENST00000558201 ENST00000440567 ENST00000559191
ENST00000557907 ENST00000558379
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLE3 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLE3 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TLE3 (NM_005078) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TLE3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE3 |
Additional cDNA sequence: AB046767.1 AK000083.1 AK001258.1 AK096779.1 AK298482.1 AK304459.1 AK315058.1 AY566265.1 AY583459.1 AY583460.1 BC012004.1 BC015421.1 BC015729.1 BC041831.1 BC043247.2 M99438.1 17 DOTS entries: DT.455582 DT.92432333 DT.75160168 DT.91884044 DT.100789745 DT.100789746 DT.91768726 DT.91768734 DT.121034495 DT.40111202 DT.91768735 DT.95085513 DT.100789748 DT.75159529 DT.95086771 DT.99941650 DT.99978166 24/247 AceView cDNA sequences (see all 247): BM991510 BM841953 AA769241 AI989693 AI278773 BF445137 BF926675 AU124621 AI936760 BM988062 BI518493 AW004632 AA523006 AI655850 AI925130 AU121082 BM930842 AI660506 AU125114 BM557893 BM969512 BF431173 AI268665 CR603419
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TLE3 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ | 14a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | |
| ExUns: | 14b | · | 14c | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TLE3
|
Expression
for TLE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TLE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATGTGGAG
About this image
See TLE3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLE3
SOURCE GeneReport for Unigene cluster: Hs.287362
UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726Tissue specificity: Placenta and lung
SABiosciences Custom PCR Arrays for TLE3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLE3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE3 |
Orthologs
for TLE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TLE3 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TLE31 |
transducin-like enhancer of split 3 (E(sp1) homolog, more |
83.88(n)
95.01(a) |
|
415568 XM_003641829.1 XP_003641877.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TLE36 |
-- |
93(a) |
1 ↔ 1 |
GL343642.1(6813-49498) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.43862 |
Transcribed sequence with moderate similarity to protein more |
79.9(n) |
|
BG512451.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AB040707.12 |
-- |
78.79(n) |
|
83411 AB040707.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
gro1 |
groucho |
65.96(n)
69.46(a) |
|
43162 NM_206575.2 NP_996298.1 |
ENSEMBL Gene Tree for TLE3 (if available)
TreeFam Gene Tree for TLE3 (if available) |
Paralogs
for TLE3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TLE3 gene
- AES2 TLE62 TLE22 TLE42 TLE12
6 SIMAP similar genes for TLE3 using alignment to 18 protein entries: TLE3_HUMAN (see all proteins):TLE1 TLE2 TLE4 AES GNB5 TLE6
TLE3 for paralogs About GeneDecksing
|
Genomic Variants
for TLE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TLE3 (70340129 - 70390515 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TLE3
1 CNV: 72272 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLE3 |
|
Disorders
/ Diseases
for TLE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TLE3 for disorders About GeneDecksing
OMIM gene information: 600190
OMIM disorders: --
4  diseases for TLE3: About MalaCardsprostate cancer prostatitis hepatitis neuronitis
Export disorders for TLE3 gene to outside databases
|
Publications
for TLE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TLE3 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with TLE3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PubMed id 10748198)1, 2 Wang J.-C....Granner D.K. (2000)
- Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3 Miyasaka H.... Li S.S.-L. (1993)
- Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (1992)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. (PubMed id 22304967)2 Hanson A.J....Lee E. (2012)
|
External Searches for TLE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TLE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TLE3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TLE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TLE3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TLE3 gene:
Search GeneIP for patents involving TLE3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TLE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TLE3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLE3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TLE3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TLE3 | | OriGene 3'-UTR Clone for TLE3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TLE3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLE3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TLE3 | | OriGene Custom Protein Services for TLE3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLE3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLE3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE3 |
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| | | | Search Tocris compounds for TLE3 |
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 | | | TLE3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE3 |
|  |  |  | | | | Search ThermoFisher Antibodies for TLE3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE3 |
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