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TLE3 Gene

protein-coding   GIFtS: 65
GCID: GC15M070341

Transducin-Like Enhancer Of Split 3

(Previous names: transducin-like enhancer of split 3, homolog of Drosophila...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transducin-Like Enhancer Of Split 31 2     GRG32
Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila)1 2     HsT189762
Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1)1 2     Enhancer Of Split Groucho 32
Enhancer Of Split Groucho-Like Protein 32 3     Transducin-Like Enhancer Protein 32
ESG32 3     KIAA15473
ESG2 5     

External Ids:    HGNC: 118391   Entrez Gene: 70902   Ensembl: ENSG000001403327   OMIM: 6001905   UniProtKB: Q047263   

Export aliases for TLE3 gene to outside databases

Previous GC identifers: GC15M066130 GC15M063439 GC15M067919 GC15M068057 GC15M068129 GC15M047172


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TLE3 Gene:
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of
proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell
fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy
with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional
alternatively spliced transcript variants of this gene have been described, but their full-length nature is not
known. (provided by RefSeq, Sep 2013)

GeneCards Summary for TLE3 Gene:
TLE3 (transducin-like enhancer of split 3) is a protein-coding gene. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length
TLE family members may be modulated by association with dominant-negative AES (By similarity)

Gene Wiki entry for TLE3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLE3 gene promoter:
         Egr-3   GATA-1   CBF-C   C/EBPalpha   MZF-1   CBF-B   CBF-A   HSF2   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TLE3 promoter sequence
   Search Chromatin IP Primers for TLE3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22

TLE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M070341:  view genomic region     (about GC identifiers)

Start:
70,340,129 bp from pter      End:
70,390,515 bp from pter
Size:
50,387 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 3  
Size: 772 amino acids; 83417 Da
Subunit: Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity).
Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4
Sequence caution: Sequence=BAB13373.1; Type=Erroneous initiation;
Secondary accessions: E9PD64 Q8IVV6 Q8WVR2 Q9HCM5
Alternative splicing: 5 isoforms:  Q04726-1   Q04726-2   Q04726-3   Q04726-4   Q04726-5   (No experimental confirmation available. Contains a N6-acetyllysine at position 343)

Explore the universe of human proteins at neXtProt for TLE3: NX_Q04726

Explore proteomics data for TLE3 at MOPED

Post-translational modifications: 

  • Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity
    to tetramerize but inhibits its interaction with TCF7L2/TCF41
  • Ubiquitination2 at Lys30, Lys720
  • Modification sites at PhosphoSitePlus

  • See TLE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001098662.1  NP_001269908.1  NP_001269909.1  NP_001269910.1  NP_001269911.1  NP_005069.2  NP_065959.1  

    ENSEMBL proteins: 
     ENSP00000452871   ENSP00000319233   ENSP00000452803   ENSP00000453219   ENSP00000454141  
     ENSP00000453081   ENSP00000453760   ENSP00000452933   ENSP00000453083   ENSP00000453373  
     ENSP00000442594   ENSP00000452881   ENSP00000415057   ENSP00000454029   ENSP00000453107  
     ENSP00000453435   ENSP00000394717   ENSP00000452809   ENSP00000457641   ENSP00000456178  
     ENSP00000390007  
    Reactome Protein details: Q04726

    TLE3 Human Recombinant Protein Products:

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    Novus Biologicals TLE3 Protein
    Novus Biologicals TLE3 Lysate
    Sino Biological Recombinant Protein for TLE3
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLE3

     
    Search eBioscience for Proteins for TLE3 

     
    antibodies-online proteins for TLE3 (4 products) 

     
    antibodies-online peptides for TLE3

    TLE3 Antibody Products:

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    antibodies-online antibodies for TLE3 (12 products) 

    TLE3 Assay Products:

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    Cloud-Clone Corp. CLIAs for TLE3
    Search eBioscience for ELISAs for TLE3 
    antibodies-online kits for TLE3 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04726

    ProtoNet protein and cluster: Q04726

    3 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with TLE3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLE3_HUMAN, Q04726
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
    transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length
    TLE family members may be modulated by association with dominant-negative AES (By similarity)

         Genatlas biochemistry entry for TLE3:
    transducin-like enhancer of split 3,with homology to Drosophila split Groucho (Notch signaling pathway)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17577209
         
    Find genes that share ontologies with TLE3           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tle3):
     adipose tissue  behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with TLE3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TLE3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TLE3:
    hsa-mir-1260b (MIRT052775), hsa-mir-93-5p (MIRT048880), hsa-mir-222-3p (MIRT046791), hsa-mir-196b-5p (MIRT042697), hsa-mir-92a-3p (MIRT049557), hsa-mir-34a-5p (MIRT047341), hsa-mir-615-3p (MIRT040320), hsa-mir-505-3p (MIRT041003), hsa-mir-10a-5p (MIRT025609), hsa-mir-18a-5p (MIRT050664), hsa-mir-296-3p (MIRT038491)

    Block miRNA regulation of human, mouse, rat TLE3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLE3 (see all 31):
    hsa-miR-3910 hsa-miR-607 hsa-miR-125a-5p hsa-miR-4311 hsa-miR-3146 hsa-miR-330-5p hsa-miR-4272 hsa-miR-548v
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TLE3

    Gene Editing
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    OriGene ORF clones in mouse, rat for TLE3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TLE3 (NM_005078)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE3

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE3

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13286) for TLE3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLE3_HUMAN, Q04726: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1303260
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with TLE3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLE3 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.64
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Signaling by GPCR
    Signal Transduction0.58
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50
    5Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40


    Find genes that share SuperPaths with TLE3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TLE3
        Wnt Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TLE3
        GSK3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TLE3
        Development Notch Signaling Pathway


    3 Reactome Pathways for TLE3
        NOTCH1 Intracellular Domain Regulates Transcription
    deactivation of the beta-catenin transactivating complex
    formation of the beta-catenin:TCF transactivating complex


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TLE3
    Interactions:

        Search GeneGlobe Interaction Network for TLE3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLE3 (Q047262, 3 ENSP000003192334) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3AQ71DI33I2D: score=1 
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    SIX3O953433, ENSP000002606534I2D: score=3 STRING: ENSP00000260653
    AESQ081173, ENSP000002215614I2D: score=2 STRING: ENSP00000221561
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007165signal transduction TAS8808280
    GO:0007219Notch signaling pathway TAS--
    GO:0009887organ morphogenesis TAS8808280

    Find genes that share ontologies with TLE3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLE3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLE3 gene (7 alternative transcripts): 
    NM_001105192.2  NM_001282979.1  NM_001282980.1  NM_001282981.1  NM_001282982.1  NM_005078.3  NM_020908.2  

    Unigene Cluster for TLE3:

    Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
    Hs.287362  [show with all ESTs]
    Unigene Representative Sequence: NM_005078
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000558939(uc002ask.2 uc002asl.2 uc010ukd.1 uc010bil.1 uc002asn.2 uc002asm.2 uc002asp.2 uc002aso.2)
    ENST00000317509 ENST00000557919 ENST00000560525 ENST00000557815 ENST00000560589
    ENST00000559929 ENST00000559048 ENST00000560939 ENST00000557997 ENST00000561453
    ENST00000559608 ENST00000539550 ENST00000558201 ENST00000440567 ENST00000559191
    ENST00000557907 ENST00000558379
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TLE3 (see all 31):
    hsa-miR-3910 hsa-miR-607 hsa-miR-125a-5p hsa-miR-4311 hsa-miR-3146 hsa-miR-330-5p hsa-miR-4272 hsa-miR-548v
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    GenScript: all cDNA clones in your preferred vector (see all 3): TLE3 (NM_005078)
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    Primer
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13286) for TLE3 

    Additional mRNA sequence: 

    AB046767.1 AK000083.1 AK001258.1 AK096779.1 AK298482.1 AK304459.1 AK315058.1 AY566265.1 
    AY583459.1 AY583460.1 BC012004.1 BC015421.1 BC015729.1 BC041831.1 BC043247.2 M99438.1 

    17 DOTS entries:

    DT.455582  DT.92432333  DT.75160168  DT.91884044  DT.100789745  DT.100789746  DT.91768726  DT.91768734 
    DT.121034495  DT.40111202  DT.91768735  DT.95085513  DT.100789748  DT.75159529  DT.95086771  DT.99941650 
    DT.99978166 

    Selected AceView cDNA sequences (see all 247):

    BM991510 AI655850 AI925130 BM930842 AU121082 AU125114 BM557893 AI268665 
    BF431173 BM969512 CR603419 AA523006 AI660506 AU124621 AI278773 BI518493 
    AW004632 AI924468 AI989693 BU620251 BF926675 BF445137 AY566265 AI936760 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TLE3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a ·
    SP1:                                                                                                                                                            
    SP2:                    -           -                             -     -                                                                                       
    SP3:                                                                                                                                      -     -     -         
    SP4:                                                                                                                                            -     -         
    SP5:                                                                                                                                                  -         

    ExUns: 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21
    SP1:        -                                                               
    SP2:                                                                        
    SP3:                                                                        
    SP4:        -                                                               
    SP5:        -                                                               


    ECgene alternative splicing isoforms for TLE3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGTGGAG
    TLE3 Expression
    About this image


    TLE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Midbrain tegmentum
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Thymus (Hematopoietic System)
             Thymus
    TLE3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLE3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287362

    UniProtKB/Swiss-Prot: TLE3_HUMAN, Q04726
    Tissue specificity: Placenta and lung

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLE3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tle31 , 5 transducin-like enhancer of split 3, homolog of Drosophila more1, 5 91.27(n)1
    98.95(a)1
      9 (33.27 cM)5
    218871  NM_001083928.11  NP_001077397.11 
     613723835 
    chicken
    (Gallus gallus)
    Aves TLE31 transducin-like enhancer of split 3 (E(sp1) homolog, more 83.94(n)
    94.66(a)
      415568  XM_003641829.2  XP_003641877.2 
    lizard
    (Anolis carolinensis)
    Reptilia TLE36
    transducin-like enhancer of split 3 (E(sp1) homolo...
    90(a)
    1 ↔ 1
    GL343642.1(6813-99512)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.43862 Transcribed sequence with moderate similarity to protein more 79.9(n)    BG512451.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB040707.12   -- 78.79(n)   83411  AB040707.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gro6
    groucho
    66(a)
    1 → many
    3R(21867432-21875633)


    ENSEMBL Gene Tree for TLE3 (if available)
    TreeFam Gene Tree for TLE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLE3 gene
    AES2  TLE62  TLE22  TLE42  TLE12  
    6 SIMAP similar genes for TLE3 using alignment to 18 protein entries:     TLE3_HUMAN (see all proteins):
    TLE1    TLE2    TLE4    AES    GNB5    TLE6

    Find genes that share paralogs with TLE3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLE3 (see all 1130)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs677627371,2
    C--50441940(+) ACACC-/A/AC  
            
    AAAAA
    6 -- ut511NA 2
    rs1826148961,2
    --70340065(+) TAAACC/GTGTTA 3 -- int10--------
    rs1885364191,2
    --70340132(+) AGTTTC/TGCTTC 3 -- int10--------
    rs1147120141,2
    F--70340315(+) CACAGT/AATGGG 3 -- int11Minor allele frequency- A:0.01WA 118
    rs759022771,2
    C,F--70340491(+) CGGGGT/GGCGGG 3 -- int11Minor allele frequency- G:0.00NA 2
    rs37433091,2
    C,F,A,H--70340511(+) CTGGGA/GGGAGA 3 -- int122Minor allele frequency- G:0.33EA NS NA CSA WA 3787
    rs1460147971,2
    --70340714(+) CCCCAC/TGCGCC 3 -- ut310--------
    rs1388523511,2
    --70340775(+) GGTGCA/GCTCAG 3 -- ut310--------
    rs717944091,2
    C--70340988(+) AAGGA-/AAAAAA 3 -- ut310--------
    rs110721331,2
    C,H--70340989(+) aaaggA/Gaaaaa 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TLE3 (70340129 - 70390515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TLE3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672644CNV Deletion23128226
    esv25961CNV Loss19812545
    nsv827380CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TLE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600190    OMIM disorders: --


    Find genes that share disorders with TLE3           About GenesLikeMe

    Genetic Association Database (GAD): TLE3

    Export disorders for TLE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLE3 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with TLE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PubMed id 10748198)1, 2 Wang J.-C....Granner D.K. (J. Biol. Chem. 2000)
    7. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3 Miyasaka H.... Li S.S.-L. (Eur. J. Biochem. 1993)
    8. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (Nat. Genet. 1992)
    9. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    10. Genome-wide association study of lung function phenotypes in a founder population. (PubMed id 23932459)1 Yao T.C....Ober C. (J. Allergy Clin. Immunol. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7090 HGNC: 11839 AceView: TLE3 Ensembl:ENSG00000140332 euGenes: HUgn7090
    ECgene: TLE3 H-InvDB: TLE3

    (According to HUGE)
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    HUGE: KIAA1547

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLE3 gene:
    Search GeneIP for patents involving TLE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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