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Aliases for TLE3 Gene

Aliases for TLE3 Gene

  • Transducin Like Enhancer Of Split 3 2 3 5
  • Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 3 3 4
  • ESG3 3 4
  • Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1) 3
  • Transducin-Like Enhancer Of Split 3 Short Isoform 3
  • Enhancer Of Split Groucho 3 3
  • HsT18976 3
  • KIAA1547 4
  • GRG3 3
  • ESG 3

External Ids for TLE3 Gene

Previous GeneCards Identifiers for TLE3 Gene

  • GC15M066130
  • GC15M063439
  • GC15M067919
  • GC15M068057
  • GC15M068129
  • GC15M070341
  • GC15M047172

Summaries for TLE3 Gene

Entrez Gene Summary for TLE3 Gene

  • This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

GeneCards Summary for TLE3 Gene

TLE3 (Transducin Like Enhancer Of Split 3) is a Protein Coding gene. Among its related pathways are Wnt / Hedgehog / Notch and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot for TLE3 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Wiki entry for TLE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE3 Gene

Genomics for TLE3 Gene

Regulatory Elements for TLE3 Gene

Enhancers for TLE3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TLE3 on UCSC Golden Path with GeneCards custom track

Promoters for TLE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLE3 Gene

Chromosome:
15
Start:
70,047,790 bp from pter
End:
70,098,176 bp from pter
Size:
50,387 bases
Orientation:
Minus strand

Genomic View for TLE3 Gene

Genes around TLE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE3 Gene

Proteins for TLE3 Gene

  • Protein details for TLE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04726-TLE3_HUMAN
    Recommended name:
    Transducin-like enhancer protein 3
    Protein Accession:
    Q04726
    Secondary Accessions:
    • B4DPT0
    • E9PD64
    • F8W964
    • Q6PI57
    • Q8IVV6
    • Q8WVR2
    • Q9HCM5

    Protein attributes for TLE3 Gene

    Size:
    772 amino acids
    Molecular mass:
    83417 Da
    Quaternary structure:
    • Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. Interacts with TBX18 (via engrailed homology 1 repressor motif), leading to decreased of TBX18 transcriptional activity.
    SequenceCaution:
    • Sequence=BAB13373.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE3 Gene

neXtProt entry for TLE3 Gene

Proteomics data for TLE3 Gene at MOPED

Post-translational modifications for TLE3 Gene

  • Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4.
  • Ubiquitination at Lys 30 and Lys 343
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TLE3 Gene

Domains & Families for TLE3 Gene

Gene Families for TLE3 Gene

Graphical View of Domain Structure for InterPro Entry

Q04726

UniProtKB/Swiss-Prot:

TLE3_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
  • Contains 7 WD repeats.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with TLE3: view

Function for TLE3 Gene

Molecular function for TLE3 Gene

GENATLAS Biochemistry:
transducin-like enhancer of split 3,with homology to Drosophila split Groucho (Notch signaling pathway)
UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
genes like me logo Genes that share phenotypes with TLE3: view

Animal Models for TLE3 Gene

MGI Knock Outs for TLE3:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE3 Gene

Localization for TLE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLE3 Gene COMPARTMENTS Subcellular localization image for TLE3 gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for TLE3 Gene

Pathways & Interactions for TLE3 Gene

genes like me logo Genes that share pathways with TLE3: view

Gene Ontology (GO) - Biological Process for TLE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8808280
GO:0007219 Notch signaling pathway TAS --
GO:0009887 organ morphogenesis TAS 8808280
GO:0016055 Wnt signaling pathway IEA --
GO:1904837 beta-catenin-TCF complex assembly TAS --
genes like me logo Genes that share ontologies with TLE3: view

No data available for SIGNOR curated interactions for TLE3 Gene

Drugs & Compounds for TLE3 Gene

(6) Drugs for TLE3 Gene - From: ClinicalTrials and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Inhibition, inhibitor, Biomarker Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
Paclitaxel Approved Pharma inhibitor, Biomarker, binder Tubulin and Bcl2 inhibitor, Taxanes 2655
Epirubicin Approved Pharma 366
Lidocaine Approved Pharma Antagonist, Pore Blocker Anasthetic and class Ib antiarrhythmic agent 1138
Albumin-Bound Paclitaxel Pharma 2655
genes like me logo Genes that share compounds with TLE3: view

Transcripts for TLE3 Gene

Unigene Clusters for TLE3 Gene

Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLE3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a ·
SP1:
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -
SP7: -
SP8: - -
SP9:
SP10: -
SP11: -
SP12:

ExUns: 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TLE3 Gene

GeneLoc Exon Structure for
TLE3
ECgene alternative splicing isoforms for
TLE3

Expression for TLE3 Gene

mRNA expression in normal human tissues for TLE3 Gene

mRNA differential expression in normal tissues according to GTEx for TLE3 Gene

This gene is overexpressed in Whole Blood (x10.2).

Protein differential expression in normal tissues from HIPED for TLE3 Gene

This gene is overexpressed in Placenta (11.4), CD8 Tcells (8.4), and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLE3 Gene



SOURCE GeneReport for Unigene cluster for TLE3 Gene Hs.287362

mRNA Expression by UniProt/SwissProt for TLE3 Gene

Q04726-TLE3_HUMAN
Tissue specificity: Placenta and lung.
genes like me logo Genes that share expression patterns with TLE3: view

Protein tissue co-expression partners for TLE3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TLE3 Gene

Orthologs for TLE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLE3 35
  • 93.45 (n)
  • 99.22 (a)
TLE3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLE3 35
  • 93.27 (n)
  • 99.58 (a)
TLE3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tle3 35
  • 91.27 (n)
  • 98.95 (a)
Tle3 16
Tle3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLE3 35
  • 99.87 (n)
  • 99.87 (a)
TLE3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tle3 35
  • 91.84 (n)
  • 99.21 (a)
oppossum
(Monodelphis domestica)
Mammalia TLE3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLE3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLE3 35
  • 83.94 (n)
  • 94.66 (a)
TLE3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLE3 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4386 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
gro1 35
  • 80.31 (n)
  • 92.63 (a)
gro1 36
  • 92 (a)
OneToMany
gro2 36
  • 89 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9672 35
fruit fly
(Drosophila melanogaster)
Insecta gro 36
  • 66 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10712 36
  • 51 (a)
ManyToMany
CSA.8664 36
  • 55 (a)
ManyToMany
Species with no ortholog for TLE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLE3 Gene

ENSEMBL:
Gene Tree for TLE3 (if available)
TreeFam:
Gene Tree for TLE3 (if available)

Paralogs for TLE3 Gene

Paralogs for TLE3 Gene

genes like me logo Genes that share paralogs with TLE3: view

Variants for TLE3 Gene

Sequence variations from dbSNP and Humsavar for TLE3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1057864 - 70,060,558(-) GAAGG(C/T)GGAGG reference, missense
rs5813573 -- 70,066,198(+) AGGTG(-/C)TGCGC intron-variant, reference, frameshift-variant
rs591181 -- 70,065,857(-) AGCCA(A/G)TGCCA intron-variant
rs592138 -- 70,065,633(-) CAAAG(C/T)TGAGT intron-variant
rs593011 -- 70,065,452(-) AGCTG(A/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE3 Gene

Variant ID Type Subtype PubMed ID
nsv827380 CNV Gain 20364138
esv2672644 CNV Deletion 23128226
esv25961 CNV Loss 19812545

Variation tolerance for TLE3 Gene

Residual Variation Intolerance Score: 3.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLE3 Gene

HapMap Linkage Disequilibrium report
TLE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE3 Gene

Disorders for TLE3 Gene

Relevant External Links for TLE3

Genetic Association Database (GAD)
TLE3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLE3

No disorders were found for TLE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE3 Gene

Publications for TLE3 Gene

  1. Mutations in TBX18 cause dominant urinary tract malformations via transcriptional dysregulation of ureter development. (PMID: 26235987) Vivante A. … Hildebrandt F. (Am. J. Hum. Genet. 2015) 3 4 67
  2. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PMID: 8365415) Miyasaka H. … Li S.S.-L. (Eur. J. Biochem. 1993) 2 3
  3. Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARI^ gene expression. (PMID: 25249007) Ortega F.J. … FernA!ndez-Real J.M. (J. Mol. Med. 2015) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for TLE3 Gene

Sources for TLE3 Gene

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