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Aliases for TLE2 Gene

Aliases for TLE2 Gene

  • Transducin Like Enhancer Of Split 2 2 3 5
  • Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 2 3 4
  • ESG2 3 4
  • Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1) 3
  • Enhancer Of Split Groucho 2 2
  • GRG2 3
  • ESG 3

External Ids for TLE2 Gene

Previous GeneCards Identifiers for TLE2 Gene

  • GC19M003089
  • GC19M002937
  • GC19M002948
  • GC19M002765

Summaries for TLE2 Gene

GeneCards Summary for TLE2 Gene

TLE2 (Transducin Like Enhancer Of Split 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by NOTCH1. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot for TLE2 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Wiki entry for TLE2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE2 Gene

Genomics for TLE2 Gene

Regulatory Elements for TLE2 Gene

Promoters for TLE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLE2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TLE2 gene promoter:

Genomic Location for TLE2 Gene

Chromosome:
19
Start:
2,997,638 bp from pter
End:
3,047,635 bp from pter
Size:
49,998 bases
Orientation:
Minus strand

Genomic View for TLE2 Gene

Genes around TLE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE2 Gene

Proteins for TLE2 Gene

  • Protein details for TLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04725-TLE2_HUMAN
    Recommended name:
    Transducin-like enhancer protein 2
    Protein Accession:
    Q04725
    Secondary Accessions:
    • B4DE03
    • E9PEV7
    • F8WCH2
    • Q8WVY0
    • Q9Y6S0

    Protein attributes for TLE2 Gene

    Size:
    743 amino acids
    Molecular mass:
    79841 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.
    SequenceCaution:
    • Sequence=AK308137; Type=Frameshift; Positions=537; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE2 Gene

Proteomics data for TLE2 Gene at MOPED

Post-translational modifications for TLE2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLE2 (TLE2)

No data available for DME Specific Peptides for TLE2 Gene

Domains & Families for TLE2 Gene

Gene Families for TLE2 Gene

Suggested Antigen Peptide Sequences for TLE2 Gene

Graphical View of Domain Structure for InterPro Entry

Q04725

UniProtKB/Swiss-Prot:

TLE2_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
  • Contains 6 WD repeats.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with TLE2: view

Function for TLE2 Gene

Molecular function for TLE2 Gene

GENATLAS Biochemistry:
transducin-like enhancer of split 2,with homology to Drosophila split Groucho (Notch signaling pathway) mainly expressed in muscle,placenta
UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
genes like me logo Genes that share phenotypes with TLE2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLE2 Gene

Localization for TLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLE2 Gene COMPARTMENTS Subcellular localization image for TLE2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TLE2 Gene

Pathways & Interactions for TLE2 Gene

genes like me logo Genes that share pathways with TLE2: view

Pathways by source for TLE2 Gene

SIGNOR curated interactions for TLE2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway TAS --
GO:0009887 organ morphogenesis TAS 8808280
GO:0016055 Wnt signaling pathway IEA --
GO:0090090 negative regulation of canonical Wnt signaling pathway IDA 19460168
GO:1904837 beta-catenin-TCF complex assembly TAS --
genes like me logo Genes that share ontologies with TLE2: view

Drugs & Compounds for TLE2 Gene

No Compound Related Data Available

Transcripts for TLE2 Gene

Unigene Clusters for TLE2 Gene

Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLE2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: -

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TLE2 Gene

GeneLoc Exon Structure for
TLE2
ECgene alternative splicing isoforms for
TLE2

Expression for TLE2 Gene

mRNA expression in normal human tissues for TLE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE2 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5) and Brain - Cerebellar Hemisphere (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLE2 Gene



SOURCE GeneReport for Unigene cluster for TLE2 Gene Hs.332173

mRNA Expression by UniProt/SwissProt for TLE2 Gene

Q04725-TLE2_HUMAN
Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle.
genes like me logo Genes that share expression patterns with TLE2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for TLE2 Gene

Orthologs for TLE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLE2 35
  • 90.36 (n)
  • 95.64 (a)
TLE2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLE2 35
  • 89.55 (n)
  • 95.86 (a)
TLE2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tle2 35
  • 84.82 (n)
  • 91.76 (a)
Tle2 16
Tle2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLE2 35
  • 96.46 (n)
  • 97.14 (a)
TLE2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tle2 35
  • 84.8 (n)
  • 91.63 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:136336 36
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta gro 37
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-37 37
  • 56 (a)
Species with no ortholog for TLE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLE2 Gene

ENSEMBL:
Gene Tree for TLE2 (if available)
TreeFam:
Gene Tree for TLE2 (if available)

Paralogs for TLE2 Gene

Paralogs for TLE2 Gene

(7) SIMAP similar genes for TLE2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TLE2 Gene

genes like me logo Genes that share paralogs with TLE2: view

Variants for TLE2 Gene

Sequence variations from dbSNP and Humsavar for TLE2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs199788562 - 3,009,574(+) GCTGC(C/T)GACCT intron-variant, reference, missense
rs11150 -- 2,997,899(-) TACAT(A/C/T)GTGAC reference, synonymous-codon, utr-variant-3-prime
rs14089 -- 2,997,792(-) CAGCC(A/G)GGACA utr-variant-3-prime
rs373172 -- 3,002,899(+) TCACC(A/G)TATTG intron-variant
rs375069 -- 2,999,034(+) ctcgg(C/T)gcttc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE2 Gene

Variant ID Type Subtype PubMed ID
nsv833709 CNV Loss 17160897
nsv910694 CNV Loss 21882294
dgv47n68 CNV Loss 17160897
nsv910695 CNV Loss 21882294
nsv2391 CNV Insertion 18451855
dgv3644n71 CNV Loss 21882294
nsv910697 CNV Loss 21882294
nsv910700 CNV Loss 21882294
nsv910702 CNV Loss 21882294

Variation tolerance for TLE2 Gene

Residual Variation Intolerance Score: 9.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLE2 Gene

HapMap Linkage Disequilibrium report
TLE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE2 Gene

Disorders for TLE2 Gene

Relevant External Links for TLE2

Genetic Association Database (GAD)
TLE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLE2

No disorders were found for TLE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE2 Gene

Publications for TLE2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. (PMID: 19939918) He Z. … Lan K. (J. Virol. 2010) 3 23
  3. Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. (PMID: 8808280) Liu Y. … Stifani S. (Genomics 1996) 2 3
  4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for TLE2 Gene

Sources for TLE2 Gene

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