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TLE2 Gene

protein-coding   GIFtS: 64
GCID: GC19M002997

Transducin-Like Enhancer Of Split 2

(Previous names: transducin-like enhancer of split 2, homolog of Drosophila...)
  See TLE2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transducin-Like Enhancer Of Split 21 2     Enhancer Of Split Groucho-Like Protein 22 3
ESG22 3 5     ESG2
Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila)1 2     GRG22
Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1)1 2     Transducin-Like Enhancer Protein 22
Enhancer Of Split Groucho 21 2     

External Ids:    HGNC: 118381   Entrez Gene: 70892   Ensembl: ENSG000000657177   OMIM: 6010415   UniProtKB: Q047253   

Export aliases for TLE2 gene to outside databases

Previous GC identifers: GC19M003089 GC19M002937 GC19M002948 GC19M002765


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TLE2 Gene:
TLE2 (transducin-like enhancer of split 2) is a protein-coding gene. Diseases associated with TLE2 include spindle cell sarcoma. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length
TLE family members may be modulated by association with dominant-negative AES (By similarity)

Gene Wiki entry for TLE2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLE2 gene promoter:
         p53   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLE2 promoter sequence
   Search Chromatin IP Primers for TLE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TLE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002997:  view genomic region     (about GC identifiers)

Start:
2,997,636 bp from pter      End:
3,047,633 bp from pter
Size:
49,998 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 2  
Size: 743 amino acids; 79841 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1
and HES5
Sequence caution: Sequence=AK308137; Type=Frameshift; Positions=537;
Secondary accessions: B4DE03 E9PEV7 F8WCH2 Q8WVY0 Q9Y6S0
Alternative splicing: 3 isoforms:  Q04725-1   Q04725-2   Q04725-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLE2: NX_Q04725

Explore proteomics data for TLE2 at MOPED

Post-translational modifications: 

  • Ubiquitinated by XIAP/BIRC41
  • Ubiquitination2 at Lys29, Lys691
  • Modification sites at PhosphoSitePlus

  • See TLE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138233.1  NP_001138234.1  NP_003251.2  

    ENSEMBL proteins: 
     ENSP00000262953   ENSP00000468279   ENSP00000465519   ENSP00000392427   ENSP00000466542  
     ENSP00000465292   ENSP00000467337   ENSP00000467358   ENSP00000468666   ENSP00000413107  
     ENSP00000406523   ENSP00000392869  
    Reactome Protein details: Q04725

    TLE2 Human Recombinant Protein Products:

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    Novus Biologicals TLE2 Protein
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    TLE2 Antibody Products:

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    Search eBioscience for ELISAs for TLE2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04725

    ProtoNet protein and cluster: Q04725

    3 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 6 WD repeats


    Find genes that share domains with TLE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLE2_HUMAN, Q04725
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
    transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length
    TLE family members may be modulated by association with dominant-negative AES (By similarity)

         Genatlas biochemistry entry for TLE2:
    transducin-like enhancer of split 2,with homology to Drosophila split Groucho (Notch signaling pathway) mainly
    expressed in muscle,placenta

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IDA19460168
    GO:0005515protein binding IPI17041588
         
    Find genes that share ontologies with TLE2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TLE2:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TLE2
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    miRNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLE2_HUMAN, Q04725: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus TAS1303260
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with TLE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLE2 About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.64
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Signaling by GPCR
    Signal Transduction0.58
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50
    5Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40


    Find genes that share SuperPaths with TLE2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TLE2
        Wnt Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TLE2
        GSK3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TLE2
        Development Notch Signaling Pathway

    1 BioSystems Pathway for TLE2
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    3 Reactome Pathways for TLE2
        NOTCH1 Intracellular Domain Regulates Transcription
    deactivation of the beta-catenin transactivating complex
    formation of the beta-catenin:TCF transactivating complex


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TLE2
    Interactions:

        Search GeneGlobe Interaction Network for TLE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLE2 (Q047251, 3 ENSP000002629534) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H3F3BP842433, ENSP000002548104I2D: score=1 STRING: ENSP00000254810
    DDB1Q165311, 3, ENSP000003017644EBI-1176061,EBI-350322 I2D: score=1 STRING: ENSP00000301764
    UTYO146073, ENSP000003289394I2D: score=3 STRING: ENSP00000328939
    RUNX1Q011963, ENSP000003003054I2D: score=2 STRING: ENSP00000300305
    H3F3AP842433I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007165signal transduction TAS8808280
    GO:0007219Notch signaling pathway TAS--
    GO:0009887organ morphogenesis TAS8808280

    Find genes that share ontologies with TLE2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLE2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLE2 gene (3 alternative transcripts): 
    NM_001144761.1  NM_001144762.1  NM_003260.4  

    Unigene Cluster for TLE2:

    Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
    Hs.332173  [show with all ESTs]
    Unigene Representative Sequence: NM_003260
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000262953(uc002lww.3 uc010dth.3 uc010dti.3 uc010xhd.1)
    ENST00000591529 ENST00000586422 ENST00000443826 ENST00000590536 ENST00000589364
    ENST00000586492 ENST00000587672 ENST00000589205 ENST00000587217 ENST00000591457
    ENST00000590101 ENST00000587137 ENST00000590183 ENST00000589291 ENST00000592584
    ENST00000587770 ENST00000592305
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TLE2
      QuantiFast Probe-based Assays in human, mouse, rat TLE2

    Additional mRNA sequence: 

    AK123183.1 AK293407.1 AK293482.1 AK303102.1 AK308137.1 AK308608.1 AK312285.1 BC017364.2 
    M99436.1 

    11 DOTS entries:

    DT.85105456  DT.101979956  DT.95185704  DT.95207993  DT.121483837  DT.95207989  DT.100765186  DT.121483839 
    DT.121483812  DT.422720  DT.91661133 

    Selected AceView cDNA sequences (see all 156):

    CK902320 BM835515 BM980776 BF312524 AI681385 CA431711 BM977785 CA391365 
    BM663833 CA313714 CA398012 BM850780 CD245594 BM789826 BU956145 H25976 
    BU678020 BX105520 CD672186 AW302369 CA391534 BM931931 BU633269 BE312052 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TLE2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
    SP1:                                                                                                                                                            
    SP2:                                -     -     -     -           -           -     -                                                                           
    SP3:                                -     -     -     -           -           -     -                                                                           
    SP4:                                                                                                                                -                           
    SP5:                                -     -     -     -           -                                                                                             

    ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TLE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGGCCGA
    TLE2 Expression
    About this image


    TLE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    TLE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.332173

    UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
    Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TLE2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tle21 , 5 transducin-like enhancer of split 2, homolog of Drosophila more1, 5 84.82(n)1
    91.76(a)1
      10 (39.72 cM)5
    218861  NM_019725.21  NP_062699.11 
     815745615 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    38(a)
    many ↔ many
    JH375571.1(86-2102)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    GL344313.1(393-19087)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1363366
    zgc:136336
    43(a)
    many ↔ many
    2(52954905-53014572) ENSDARG00000067832


    ENSEMBL Gene Tree for TLE2 (if available)
    TreeFam Gene Tree for TLE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLE2 gene
    AES2  TLE32  TLE62  TLE42  TLE12  
    7 SIMAP similar genes for TLE2 using alignment to 8 protein entries:     TLE2_HUMAN (see all proteins):
    AES    TLE3    TLE1    TLE4    GNB5    TLE6
    WSB1

    Find genes that share paralogs with TLE2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TLE2
    PGOHUM00000259083


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLE2 (see all 1481)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497396651,2
    --2997146(+) ACATGG/TAGAAA 3 -- int10--------
    rs46131891,2
    C,F,A,H--2997153(+) GAAACC/ATTGTC 3 -- int110Minor allele frequency- A:0.16NA WA CSA 19
    rs1891656641,2
    --2997197(+) TGGTGG/TTCCTG 3 -- int10--------
    rs1928470121,2
    --2997217(+) CTACTC/GGGGAG 3 -- int10--------
    rs1829367411,2
    --2997242(+) ATTGCC/TTAAGC 3 -- int10--------
    rs602036111,2
    C,F--2997276(+) GCTGAG/CATCGT 3 -- int11Minor allele frequency- C:0.50WA 2
    rs1868471881,2
    --2997307(+) GGGAGA/GCAGAG 3 -- int10--------
    rs1476162451,2
    --2997324(+) TGTCTC/GAAAAA 3 -- int10--------
    rs1490589701,2
    --2997377(+) CCGTAC/TACCAT 3 -- int10--------
    rs771960391,2
    C,F--2997466(+) TGCCCA/TGCGCA 3 -- int12Minor allele frequency- T:0.06WA NA 238

    HapMap Linkage Disequilibrium report for TLE2 (2997636 - 3047633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TLE2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2391CNV Insertion18451855
    nsv910702CNV Loss21882294
    nsv833709CNV Loss17160897
    nsv910700CNV Loss21882294
    nsv910695CNV Loss21882294
    nsv910694CNV Loss21882294
    dgv3644n71CNV Loss21882294
    dgv47n68CNV Loss17160897
    nsv910697CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLE2
    DNA2.0 Custom Variant and Variant Library Synthesis for TLE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601041    OMIM disorders: --

    1 disease for TLE2:    
    About MalaCards
    spindle cell sarcoma

    1 disease from the University of Copenhagen DISEASES database for TLE2:
    Spindle cell sarcoma

    Find genes that share disorders with TLE2           About GenesLikeMe

    Genetic Association Database (GAD): TLE2

    Export disorders for TLE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLE2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TLE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. (PubMed id 11266540)1, 2 Brantjes H.... Clevers H. (Nucleic Acids Res. 2001)
    5. Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. (PubMed id 9854018)1, 2 Grbavec D.... Stifani S. (Biochem. J. 1999)
    6. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PubMed id 9874198)1, 2 Grbavec D.... Stifani S. (Eur. J. Biochem. 1998)
    7. Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. (PubMed id 8808280)1, 3 Liu Y....Stifani S. (Genomics 1996)
    8. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (Nat. Genet. 1992)
    9. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. (PubMed id 19939918)1, 9 He Z....Lan K. (J. Virol. 2010)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7089 HGNC: 11838 AceView: TLE2 Ensembl:ENSG00000065717 euGenes: HUgn7089
    ECgene: TLE2 H-InvDB: TLE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TLE2 gene:
    Search GeneIP for patents involving TLE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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