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Aliases for TLE2 Gene

Aliases for TLE2 Gene

  • Transducin Like Enhancer Of Split 2 2 3 5
  • Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 2 3 4
  • ESG2 3 4
  • Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1) 3
  • Transducin-Like Enhancer Protein 2 3
  • Enhancer Of Split Groucho 2 2
  • GRG2 3
  • ESG 3

External Ids for TLE2 Gene

Previous GeneCards Identifiers for TLE2 Gene

  • GC19M003089
  • GC19M002937
  • GC19M002948
  • GC19M002765

Summaries for TLE2 Gene

GeneCards Summary for TLE2 Gene

TLE2 (Transducin Like Enhancer Of Split 2) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is TLE3.

UniProtKB/Swiss-Prot for TLE2 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Wiki entry for TLE2 Gene

Additional gene information for TLE2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE2 Gene

Genomics for TLE2 Gene

Regulatory Elements for TLE2 Gene

Enhancers for TLE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H003150 2 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -105.8 -105754 6 HDGF PKNOX1 FOXA2 ARNT YBX1 ZNF766 FOS DEK SP3 JUNB ZNF77 CACTIN GNA11 ZNF555 CACTIN-AS1 DOT1L SPPL2B SF3A2 AP3D1 GNA15
GH19H002968 1.5 FANTOM5 Ensembl ENCODE 14.6 +75.7 75724 7 PKNOX1 FEZF1 TCF12 ZNF121 ZNF766 GLIS2 GATA2 ATF7 NCOA1 REST NCLN TLE6 TLE2 AES ZNF77 GNA11 LOC101928631 ZNF57 S1PR4 ENSG00000267283
GH19H002615 2 FANTOM5 Ensembl ENCODE dbSUPER 10 +422.9 422935 17.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF77 GADD45B SF3A2 RNU6-993P GNA11 SLC39A3 PEAK3 CACTIN-AS1 TLE2 DOT1L
GH19H003550 1.8 FANTOM5 ENCODE dbSUPER 10.3 -507.5 -507489 8.7 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF207 CACTIN ZNF77 CCDC94 C19orf71 ENSG00000267030 HDGFL2 ENSG00000266959 LOC105372244 ENSG00000267063 MFSD12
GH19H002160 1.8 FANTOM5 ENCODE dbSUPER 9.9 +879.9 879895 13.7 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D GLIS1 ZNF77 DOT1L AP3D1 CIRBP GADD45B DAZAP1 LOC100288123 SF3A2 ZNF554 TCF3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLE2 on UCSC Golden Path with GeneCards custom track

Promoters for TLE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105979 35 801 HDGF PKNOX1 ATF1 ARNT ZNF2 TCF12 ZNF121 GTF3C2 GATA2 KLF7

Transcription factor binding sites by QIAGEN in the TLE2 gene promoter:

Genomic Locations for TLE2 Gene

Genomic Locations for TLE2 Gene
chr19:2,997,638-3,047,635
(GRCh38/hg38)
Size:
49,998 bases
Orientation:
Minus strand
chr19:2,997,636-3,047,633
(GRCh37/hg19)

Genomic View for TLE2 Gene

Genes around TLE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE2 Gene

Proteins for TLE2 Gene

  • Protein details for TLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04725-TLE2_HUMAN
    Recommended name:
    Transducin-like enhancer protein 2
    Protein Accession:
    Q04725
    Secondary Accessions:
    • B4DE03
    • E9PEV7
    • F8WCH2
    • Q8WVY0
    • Q9Y6S0

    Protein attributes for TLE2 Gene

    Size:
    743 amino acids
    Molecular mass:
    79841 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.
    SequenceCaution:
    • Sequence=AK308137; Type=Frameshift; Positions=537; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE2 Gene

Post-translational modifications for TLE2 Gene

No data available for DME Specific Peptides for TLE2 Gene

Domains & Families for TLE2 Gene

Gene Families for TLE2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TLE2 Gene

Graphical View of Domain Structure for InterPro Entry

Q04725

UniProtKB/Swiss-Prot:

TLE2_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE2: view

Function for TLE2 Gene

Molecular function for TLE2 Gene

GENATLAS Biochemistry:
transducin-like enhancer of split 2,with homology to Drosophila split Groucho (Notch signaling pathway) mainly expressed in muscle,placenta
UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Phenotypes From GWAS Catalog for TLE2 Gene

Gene Ontology (GO) - Molecular Function for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 19460168
GO:0005515 protein binding IPI 17041588
genes like me logo Genes that share ontologies with TLE2: view
genes like me logo Genes that share phenotypes with TLE2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLE2 Gene

Localization for TLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA,TAS --
GO:0005654 nucleoplasm TAS --
GO:0005925 focal adhesion IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with TLE2: view

Pathways & Interactions for TLE2 Gene

genes like me logo Genes that share pathways with TLE2: view

SIGNOR curated interactions for TLE2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 8808280
GO:0009887 animal organ morphogenesis TAS 8808280
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TLE2: view

Drugs & Compounds for TLE2 Gene

No Compound Related Data Available

Transcripts for TLE2 Gene

Unigene Clusters for TLE2 Gene

Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLE2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: -

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TLE2 Gene

GeneLoc Exon Structure for
TLE2
ECgene alternative splicing isoforms for
TLE2

Expression for TLE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE2 Gene

This gene is overexpressed in Brain - Cerebellum (x6.5) and Brain - Cerebellar Hemisphere (x5.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLE2 Gene



NURSA nuclear receptor signaling pathways regulating expression of TLE2 Gene:

TLE2

SOURCE GeneReport for Unigene cluster for TLE2 Gene:

Hs.332173

mRNA Expression by UniProt/SwissProt for TLE2 Gene:

Q04725-TLE2_HUMAN
Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle.

Evidence on tissue expression from TISSUES for TLE2 Gene

  • Nervous system(4.7)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TLE2: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE2 Gene

Orthologs for TLE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLE2 33 34
  • 96.46 (n)
cow
(Bos Taurus)
Mammalia TLE2 33 34
  • 90.36 (n)
dog
(Canis familiaris)
Mammalia TLE2 33 34
  • 89.55 (n)
mouse
(Mus musculus)
Mammalia Tle2 33 16 34
  • 84.82 (n)
rat
(Rattus norvegicus)
Mammalia Tle2 33
  • 84.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
ManyToMany
-- 34
  • 58 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:136336 34
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta gro 35
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-37 35
  • 56 (a)
Species where no ortholog for TLE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLE2 Gene

ENSEMBL:
Gene Tree for TLE2 (if available)
TreeFam:
Gene Tree for TLE2 (if available)

Paralogs for TLE2 Gene

Paralogs for TLE2 Gene

(7) SIMAP similar genes for TLE2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TLE2 Gene

genes like me logo Genes that share paralogs with TLE2: view

Variants for TLE2 Gene

Sequence variations from dbSNP and Humsavar for TLE2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000135067 -- 3,016,233(+) AACCA(A/G)CGCCT intron-variant
rs1000204481 -- 3,030,747(+) CGCGA(C/G)AATAC intron-variant, upstream-variant-2KB
rs1000219547 -- 3,043,197(+) GATCA(C/T)GGCTC intron-variant
rs1000260471 -- 3,010,424(+) AGAAA(C/T)ATCCT intron-variant
rs1000273671 -- 3,001,793(+) TTTCT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE2 Gene

Variant ID Type Subtype PubMed ID
nsv833709 CNV loss 17160897
nsv578420 CNV loss 21841781
nsv2391 CNV insertion 18451855
nsv1144855 CNV deletion 24896259
nsv1126506 CNV deletion 24896259
nsv1112739 CNV deletion 24896259
nsv1072304 CNV deletion 25765185
nsv1071891 CNV deletion 25765185
nsv1061420 CNV gain 25217958
esv3643452 CNV loss 21293372
esv3555871 CNV deletion 23714750
dgv47n68 CNV loss 17160897

Variation tolerance for TLE2 Gene

Residual Variation Intolerance Score: 9.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE2 Gene

Disorders for TLE2 Gene

Relevant External Links for TLE2

Genetic Association Database (GAD)
TLE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLE2

No disorders were found for TLE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE2 Gene

Publications for TLE2 Gene

  1. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. (PMID: 19939918) He Z … Lan K (Journal of virology 2010) 3 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. (PMID: 11266540) Brantjes H … Clevers H (Nucleic acids research 2001) 3 4 60

Products for TLE2 Gene

Sources for TLE2 Gene

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