Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLE2 Gene

protein-coding   GIFtS: 64
GCID: GC19M002997

Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila)

(Previous names: transducin-like enhancer of split 2, homolog of Drosophila...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila)1 2     Enhancer Of Split Groucho-Like Protein 22 3
ESG22 3 5     ESG2
Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1)1 2     GRG22
Enhancer Of Split Groucho 21 2     Transducin-Like Enhancer Protein 22

External Ids:    HGNC: 118381   Entrez Gene: 70892   Ensembl: ENSG000000657177   OMIM: 6010415   UniProtKB: Q047253   

Export aliases for TLE2 gene to outside databases

Previous GC identifers: GC19M003089 GC19M002937 GC19M002948 GC19M002765


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TLE2 Gene: 
TLE2 (transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE2 include spindle cell sarcoma, and sarcoma, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein binding and transcription corepressor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length
TLE family members may be modulated by association with dominant-negative AES (By similarity)

Gene Wiki entry for TLE2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLE2 gene promoter:
         p53   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TLE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002997:  view genomic region     (about GC identifiers)

Start:
2,997,636 bp from pter      End:
3,047,633 bp from pter
Size:
49,998 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 2  
Size: 743 amino acids; 79841 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1
and HES5
Subcellular location: Nucleus
Sequence caution: Sequence=AK308137; Type=Frameshift; Positions=537;
Secondary accessions: B4DE03 E9PEV7 F8WCH2 Q8WVY0 Q9Y6S0
Alternative splicing: 3 isoforms:  Q04725-1   Q04725-2   Q04725-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLE2: NX_Q04725

Explore proteomics data for TLE2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by XIAP/BIRC4
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04725

  • TLE2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLE2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138233.1  NP_001138234.1  NP_003251.2  

    ENSEMBL proteins: 
     ENSP00000262953   ENSP00000468279   ENSP00000465519   ENSP00000392427   ENSP00000466542  
     ENSP00000465292   ENSP00000467337   ENSP00000467358   ENSP00000468666   ENSP00000413107  
     ENSP00000406523   ENSP00000392869  
    Reactome Protein details: Q04725
    Human Recombinant Protein Products for TLE2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TLE2
    OriGene Protein Over-expression Lysate for TLE2
    OriGene MassSpec for TLE2 
    OriGene Custom Protein Services for TLE2
    GenScript Custom Purified and Recombinant Proteins Services for TLE2
    Novus Biologicals TLE2 Protein
    Novus Biologicals TLE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLE2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1303260
    GO:0005654nucleoplasm TAS--

    TLE2 for ontologies           About GeneDecksing



    TLE2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of TLE2
    R&D Systems Antibodies for TLE2
    OriGene Antibodies for TLE2
    OriGene Custom Antibody Services for TLE2
    GenScript Custom Superior Antibodies Services for TLE2
    Novus Biologicals TLE2 Antibodies
    Abcam antibodies for TLE2
    Cloud-Clone Corp. Antibodies for TLE2 
    ThermoFisher Antibodies for TLE2
    LSBio Antibodies in human, mouse, rat for TLE2 

    Assay Products for TLE2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TLE2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLE2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TLE2 
    Cloud-Clone Corp. CLIAs for TLE2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04725

    ProtoNet protein and cluster: Q04725

    3 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 6 WD repeats


    TLE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLE2_HUMAN, Q04725
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the
    transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length
    TLE family members may be modulated by association with dominant-negative AES (By similarity)

         Genatlas biochemistry entry for TLE2:
    transducin-like enhancer of split 2,with homology to Drosophila split Groucho (Notch signaling pathway) mainly
    expressed in muscle,placenta

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IDA19460168
    GO:0005515protein binding IPI17041588
         
    TLE2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TLE2:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLE2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLE2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLE2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TLE2
    SwitchGear 3'UTR luciferase reporter plasmidTLE2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TLE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TLE2
    Sirion Biotech Customized adenovirus for overexpression of TLE2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TLE2 (see all 15)
    OriGene ORF clones in mouse, rat for TLE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TLE2 (NM_001144762)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE2
    Sirion Biotech Customized lentivirus for stable overexpression of TLE2 
                         Customized lentivirus expression plasmids for stable overexpression of TLE2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TLE2
    Search LifeMap BioReagents cell lines for TLE2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLE2 About   (see all 7)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH0.74
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Signaling by GPCR
    Signal Transduction0.55
    4Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway0.54
    5Wnt signaling pathway
    Wnt Signaling Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TLE2
        Development Notch Signaling Pathway

    1 R&D Systems Pathway for TLE2
        Wnt Signaling Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TLE2
        GSK3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TLE2
        Development Notch Signaling Pathway

    1 BioSystems Pathway for TLE2
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    5/11        Reactome Pathways for TLE2 (see all 11)
        NOTCH1 Intracellular Domain Regulates Transcription
    Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer



    TLE2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for TLE2 (Q047251, 3 ENSP000002629534) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H3F3BP842433, ENSP000002548104I2D: score=1 STRING: ENSP00000254810
    DDB1Q165311, 3, ENSP000003017644EBI-1176061,EBI-350322 I2D: score=1 STRING: ENSP00000301764
    UTYO146073, ENSP000003289394I2D: score=3 STRING: ENSP00000328939
    RUNX1Q011963, ENSP000003003054I2D: score=2 STRING: ENSP00000300305
    H3F3AP842433I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007165signal transduction TAS8808280
    GO:0007219Notch signaling pathway TAS--
    GO:0009887organ morphogenesis TAS8808280

    TLE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLE2

    Search CenterWatch for drugs/clinical trials and news about TLE2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLE2 gene (3 alternative transcripts): 
    NM_001144761.1  NM_001144762.1  NM_003260.4  

    Unigene Cluster for TLE2:

    Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
    Hs.332173  [show with all ESTs]
    Unigene Representative Sequence: NM_003260
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000262953(uc002lww.3 uc010dth.3 uc010dti.3 uc010xhd.1)
    ENST00000591529 ENST00000586422 ENST00000443826 ENST00000590536 ENST00000589364
    ENST00000586492 ENST00000587672 ENST00000589205 ENST00000587217 ENST00000591457
    ENST00000590101 ENST00000587137 ENST00000590183 ENST00000589291 ENST00000592584
    ENST00000587770 ENST00000592305
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TLE2
    SwitchGear 3'UTR luciferase reporter plasmidTLE2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TLE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE2
    Clone
    Products:
         
    OriGene clones in human, mouse for TLE2 (see all 15)
    OriGene ORF clones in mouse, rat for TLE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TLE2 (NM_001144762)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE2
    Sirion Biotech Customized lentivirus for stable overexpression of TLE2 
                         Customized lentivirus expression plasmids for stable overexpression of TLE2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TLE2
    OriGene qSTAR qPCR primer pairs in human, mouse for TLE2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLE2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE2

    Additional mRNA sequence: 

    AK123183.1 AK293407.1 AK293482.1 AK303102.1 AK308137.1 AK308608.1 AK312285.1 BC017364.2 
    M99436.1 

    11 DOTS entries:

    DT.85105456  DT.101979956  DT.95185704  DT.95207993  DT.121483837  DT.95207989  DT.100765186  DT.121483839 
    DT.121483812  DT.422720  DT.91661133 

    24/156 AceView cDNA sequences (see all 156):

    CD245594 BM835515 BX105520 BM663833 CK902320 AI681385 CA313714 CD672186 
    BU633269 CA391365 CA398012 CA391534 BM931931 BM789826 AW302369 BF312524 
    BM980776 BU678020 CA431711 BM977785 H25976 BU956145 BM850780 CD616709 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TLE2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
    SP1:                                                                                                                                                            
    SP2:                                -     -     -     -           -           -     -                                                                           
    SP3:                                -     -     -     -           -           -     -                                                                           
    SP4:                                                                                                                                -                           
    SP5:                                -     -     -     -           -                                                                                             

    ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TLE2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLE2 expression in normal human tissues (normalized intensities)      TLE2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGGCCGA
    TLE2 Expression
    About this image


    TLE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             limb/hindlimb   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Human Cardiac Fibroblasts-adult ventrical (HCF-av)   
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
             skeleton/axial skeleton   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon

    See TLE2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLE2

    SOURCE GeneReport for Unigene cluster: Hs.332173

    UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
    Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle

        SABiosciences Custom PCR Arrays for TLE2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TLE2
    OriGene qSTAR qPCR primer pairs in human, mouse for TLE2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TLE2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TLE2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tle21 , 5 transducin-like enhancer of split 2, homolog of Drosophila more1, 5 84.95(n)1
    92.03(a)1
      10 (39.72 cM)5
    218861  NM_019725.21  NP_062699.11 
     815745615 
    lizard
    (Anolis carolinensis)
    Reptilia TLE26
    Uncharacterized protein
    75(a)
    possible ortholog
    GL344313.1(393-19087)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-42p8.36
    --
    --
    63(a)
    41(a)
    possible ortholog
    possible ortholog
    22(21994430-22077298)
    2(52954905-53014572)
    fruit fly
    (Drosophila melanogaster)
    Insecta gro3 neurogenesis transcription co-repressor 78(a)   3 96F10   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-373 transducin-like enhancer protein 56(a)   I(6750588-6753388)   --


    ENSEMBL Gene Tree for TLE2 (if available)
    TreeFam Gene Tree for TLE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLE2 gene
    AES2  TLE32  TLE62  TLE42  TLE12  
    7 SIMAP similar genes for TLE2 using alignment to 8 protein entries:     TLE2_HUMAN (see all proteins):
    AES    TLE3    TLE1    TLE4    GNB5    TLE6
    WSB1

    TLE2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TLE2
    PGOHUM00000259083


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1481 SNPs in TLE2 are shown (see all 1481)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1497396651,2
    --2997146(+) ACATGG/TAGAAA 3 -- int10--------
    rs46131891,2
    C,F,A,H--2997153(+) GAAACC/ATTGTC 3 -- int110Minor allele frequency- A:0.16NA WA CSA 19
    rs1891656641,2
    --2997197(+) TGGTGG/TTCCTG 3 -- int10--------
    rs1928470121,2
    --2997217(+) CTACTC/GGGGAG 3 -- int10--------
    rs1829367411,2
    --2997242(+) ATTGCC/TTAAGC 3 -- int10--------
    rs602036111,2
    C,F--2997276(+) GCTGAG/CATCGT 3 -- int11Minor allele frequency- C:0.50WA 2
    rs1868471881,2
    --2997307(+) GGGAGA/GCAGAG 3 -- int10--------
    rs1476162451,2
    --2997324(+) TGTCTC/GAAAAA 3 -- int10--------
    rs1490589701,2
    --2997377(+) CCGTAC/TACCAT 3 -- int10--------
    rs771960391,2
    C,F--2997466(+) TGCCCA/TGCGCA 3 -- int12Minor allele frequency- T:0.06WA NA 238

    HapMap Linkage Disequilibrium report for TLE2 (2997636 - 3047633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TLE2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2391CNV Insertion18451855
    nsv910702CNV Loss21882294
    nsv833709CNV Loss17160897
    nsv910700CNV Loss21882294
    nsv910695CNV Loss21882294
    nsv910694CNV Loss21882294
    dgv3644n71CNV Loss21882294
    dgv47n68CNV Loss17160897
    nsv910697CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TLE2
    DNA2.0 Custom Variant and Variant Library Synthesis for TLE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601041    OMIM disorders: --

    3 diseases for TLE2:    About MalaCards
    spindle cell sarcoma    sarcoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TLE2:
    Spindle cell sarcoma

    TLE2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TLE2

    Export disorders for TLE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLE2 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with TLE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    4. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. (PubMed id 11266540)1, 2 Brantjes H.... Clevers H. (2001)
    5. Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. (PubMed id 9854018)1, 2 Grbavec D.... Stifani S. (1999)
    6. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PubMed id 9874198)1, 2 Grbavec D.... Stifani S. (1998)
    7. Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. (PubMed id 8808280)1, 3 Liu Y....Stifani S. (1996)
    8. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (1992)
    9. Cellular corepressor TLE2 inhibits replication-and-tr anscription- activator-mediated transactivation and lytic reactivation of Kapos i's sarcoma-associated herpesvirus. (PubMed id 19939918)1, 9 He Z....Lan K. (2010)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7089 HGNC: 11838 AceView: TLE2 Ensembl:ENSG00000065717 euGenes: HUgn7089
    ECgene: TLE2 H-InvDB: TLE2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLE2 gene:
    Search GeneIP for patents involving TLE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TLE2
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for TLE2 (TLE2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TLE2   OriGene RNAi products in human, mouse, rat for TLE2  
     OriGene qPCR primer pairs and template standards for TLE2   OriGene Protein Over-expression Lysate for TLE2  
     OriGene MassSpec something-or-other for TLE2   OriGene clones in human, mouse for TLE2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TLE2   OriGene Purified Protein for TLE2  
     OriGene ORF clones in mouse, rat for TLE2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TLE2   OriGene Custom Protein Services for TLE2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLE2
     QIAGEN SeqTarget long-range PCR primers for resequencing TLE2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLE2
     GenScript Custom Purified and Recombinant Proteins Services for TLE2 GenScript cDNA clones with any tag delivered in your preferred vector for TLE2
     GenScript Custom Assay Services for TLE2 GenScript Custom Superior Antibodies Services for TLE2
     GenScript Custom overexpressing Cell Line Services for TLE2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TLE2 promoter
     Search Chromatin IP Primers for TLE2
     RT2 qPCR Primer Assay in human, mouse, rat TLE2
     Search GNC Networks for TLE2
     SABiosciences PCR Arrays including human, mouse, rat TLE2
     Search Tocris compounds for TLE2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TLE2 antibodies
     TLE2 proteins
     TLE2 lysates
     Antibodies for TLE2
     See all of Abcam's Antibodies, Kits and Proteins for TLE2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TLE2
     Antibodies for TLE2
     ELISAs for TLE2
     CLIAs for TLE2
     Search LifeMap BioReagents cell lines for TLE2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE2
     SwitchGear 3'UTR luciferase reporter plasmids for TLE2
     SwitchGear Promoter luciferase reporter plasmids for TLE2
     ThermoFisher Antibodies for TLE2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TLE2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLE2
    Customized:
     lentivirus for stable overexpression of TLE2
     lentivirus expression plasmids for stable overexpression of TLE2
     adenovirus for overexpression of TLE2
     LSBio Antibodies in human, mouse, rat for TLE2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TLE2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4