Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLE2 Gene

Aliases for TLE2 Gene

  • Transducin-Like Enhancer Of Split 2 2 3
  • ESG2 3 4 6
  • Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1) 2 3
  • Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 2 3 4
  • Transducin-Like Enhancer Protein 2 3
  • Enhancer Of Split Groucho 2 2
  • GRG2 3
  • ESG 3

External Ids for TLE2 Gene

Summaries for TLE2 Gene

GeneCards Summary for TLE2 Gene

TLE2 (Transducin-Like Enhancer Of Split 2) is a Protein Coding gene. Diseases associated with TLE2 include spindle cell sarcoma. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot for TLE2 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Wiki entry for TLE2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE2 Gene

Genomics for TLE2 Gene

Genomic Location for TLE2 Gene

Start:
2,997,638 bp from pter
End:
3,047,635 bp from pter
Size:
49,998 bases
Orientation:
Minus strand

Genomic View for TLE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE2 Gene

Regulatory Elements for TLE2 Gene

Transcription factor binding sites by QIAGEN in the TLE2 gene promoter:

Proteins for TLE2 Gene

  • Protein details for TLE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04725-TLE2_HUMAN
    Recommended name:
    Transducin-like enhancer protein 2
    Protein Accession:
    Q04725
    Secondary Accessions:
    • B4DE03
    • E9PEV7
    • F8WCH2
    • Q8WVY0
    • Q9Y6S0

    Protein attributes for TLE2 Gene

    Size:
    743 amino acids
    Molecular mass:
    79841 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5
    SequenceCaution:
    • Sequence=AK308137; Type=Frameshift; Positions=537; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE2 Gene

Proteomics data for TLE2 Gene at MOPED

Post-translational modifications for TLE2 Gene

No data available for DME Specific Peptides for TLE2 Gene

Domains for TLE2 Gene

Gene Families for TLE2 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for TLE2 Gene

Graphical View of Domain Structure for InterPro Entry

Q04725

UniProtKB/Swiss-Prot:

TLE2_HUMAN
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.:
    • Q04725
Family:
  • Belongs to the WD repeat Groucho/TLE family.:
    • Q04725
Similarity:
  • Contains 6 WD repeats.:
    • Q04725
genes like me logo Genes that share domains with TLE2: view

Function for TLE2 Gene

Molecular function for TLE2 Gene

GENATLAS Biochemistry: transducin-like enhancer of split 2,with homology to Drosophila split Groucho (Notch signaling pathway) mainly expressed in muscle,placenta
UniProtKB/Swiss-Prot Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Gene Ontology (GO) - Molecular Function for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 19460168
GO:0005515 protein binding IPI 17041588
genes like me logo Genes that share ontologies with TLE2: view

Phenotypes for TLE2 Gene

GenomeRNAi human phenotypes for TLE2:
genes like me logo Genes that share phenotypes with TLE2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TLE2 Gene

Localization for TLE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLE2 Gene COMPARTMENTS Subcellular localization image for TLE2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus TAS 1303260
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with TLE2: view

Pathways for TLE2 Gene

genes like me logo Genes that share pathways with TLE2: view

Pathways by source for TLE2 Gene

Gene Ontology (GO) - Biological Process for TLE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007165 signal transduction TAS 8808280
GO:0007219 Notch signaling pathway TAS --
GO:0009887 organ morphogenesis TAS 8808280
genes like me logo Genes that share ontologies with TLE2: view

Transcripts for TLE2 Gene

Unigene Clusters for TLE2 Gene

Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLE2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
SP1:
SP2: - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - -
SP6: -
SP7: - - - - -
SP8: - -
SP9: - -
SP10: -

ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TLE2 Gene

GeneLoc Exon Structure for
TLE2
ECgene alternative splicing isoforms for
TLE2

Expression for TLE2 Gene

mRNA expression in normal human tissues for TLE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE2 Gene

This gene is overexpressed in Brain - Cerebellum (6.5) and Brain - Cerebellar Hemisphere (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLE2 Gene

SOURCE GeneReport for Unigene cluster for TLE2 Gene Hs.332173

mRNA Expression by UniProt/SwissProt for TLE2 Gene

Q04725-TLE2_HUMAN
Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle
genes like me logo Genes that share expressions with TLE2: view

Orthologs for TLE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLE2 35
  • 96.46 (n)
  • 97.14 (a)
TLE2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLE2 35
  • 90.36 (n)
  • 95.64 (a)
TLE2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLE2 35
  • 89.55 (n)
  • 95.86 (a)
TLE2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tle2 35
  • 84.82 (n)
  • 91.76 (a)
Tle2 16
Tle2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tle2 35
  • 84.8 (n)
  • 91.63 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:136336 36
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta gro 37
  • 78 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-37 37
  • 56 (a)
Species with no ortholog for TLE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLE2 Gene

ENSEMBL:
Gene Tree for TLE2 (if available)
TreeFam:
Gene Tree for TLE2 (if available)

Paralogs for TLE2 Gene

Paralogs for TLE2 Gene

Selected SIMAP similar genes for TLE2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TLE2 Gene

genes like me logo Genes that share paralogs with TLE2: view

Variants for TLE2 Gene

Sequence variations from dbSNP and Humsavar for TLE2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11150 -- 2,997,899(-) TACAT(C/T)GTGAC utr-variant-3-prime, reference, synonymous-codon
rs14089 -- 2,997,792(-) CAGCC(A/G)GGACA utr-variant-3-prime
rs83488 -- 3,006,276(-) TAGTC(A/G)CATGG intron-variant
rs188621 -- 3,017,514(-) gtgat(C/T)gtgcc intron-variant
rs216267 -- 3,012,450(+) gttct(C/T)gagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE2 Gene

Variant ID Type Subtype PubMed ID
nsv833709 CNV Loss 17160897
nsv910694 CNV Loss 21882294
dgv47n68 CNV Loss 17160897
nsv910695 CNV Loss 21882294
nsv2391 CNV Insertion 18451855
dgv3644n71 CNV Loss 21882294
nsv910697 CNV Loss 21882294
nsv910700 CNV Loss 21882294
nsv910702 CNV Loss 21882294

Relevant External Links for TLE2 Gene

HapMap Linkage Disequilibrium report
TLE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE2 Gene

Disorders for TLE2 Gene

(1) MalaCards Diseases for TLE2 Gene

Search for TLE2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TLE2 Gene

Relevant External Links for TLE2

Genetic Association Database (GAD)
TLE2
genes like me logo Genes that share disorders with TLE2: view

No data available for UniProtKB/Swiss-Prot for TLE2 Gene

Publications for TLE2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. (PMID: 19939918) He Z. … Lan K. (J. Virol. 2010) 3 23
  5. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PMID: 1303260) Stifani S. … Artavanis-Tsakonas S. (Nat. Genet. 1992) 3 4

Products for TLE2 Gene

Sources for TLE2 Gene

Back to Top

Content