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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLE2 Gene

protein-coding   GIFtS: 60
GCID: GC19M002997

transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)

(Previous names: transducin-like enhancer of split 2, homolog of Drosophila...)
 Explore 3 diseases affiliated with
TLE2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TLE2    

Aliases
for TLE2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila)1 2     Enhancer Of Split Groucho-Like Protein 22 3
ESG21 2 3 5     FLJ411881
ESG1 2     Enhancer Of Split Groucho 22
GRG21 2     Transducin-Like Enhancer Protein 22
Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1)1 2     

External Ids:    HGNC: 118381   Entrez Gene: 70892   Ensembl: ENSG000000657177   OMIM: 6010415   UniProtKB: Q047253   

Export aliases for TLE2 gene to outside databases

Previous GC identifers: GC19M003089 GC19M002937 GC19M002948 GC19M002765


Summaries
for TLE2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional
activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members
may be modulated by association with dominant-negative AES (By similarity)

Gene Wiki entry for TLE2


Genomic Views
for TLE2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLE2 gene promoter:
         p53   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TLE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002997:  view genomic region     (about GC identifiers)

Start:
 2,997,636 bp from pter      End:
 3,047,633 bp from pter
Size:
 49,998 bases      Orientation:
 minus strand

Proteins
for TLE2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 2  
Size: 743 amino acids; 79841 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and
HES5
Subcellular location: Nucleus
Sequence caution: Sequence=AK308137; Type=Frameshift; Positions=537;
Secondary accessions: B4DE03 E9PEV7 F8WCH2 Q8WVY0 Q9Y6S0
Alternative splicing: 3 isoforms:  Q04725-1   Q04725-2   Q04725-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TLE2: NX_Q04725

Post-translational modifications:

  • Ubiquitinated by XIAP/BIRC41
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04725

    • TLE2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138233.1  NP_001138234.1  NP_003251.2  

    ENSEMBL proteins: 
     ENSP00000262953   ENSP00000468279   ENSP00000465519   ENSP00000392427   ENSP00000466542  
     ENSP00000465292   ENSP00000467337   ENSP00000467358   ENSP00000468666   ENSP00000413107  
     ENSP00000406523   ENSP00000392869  
    Reactome Protein details: Q04725
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TLE2
    OriGene Protein Over-expression Lysate: TLE2
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    Novus Biologicals TLE2 Protein
    Novus Biologicals TLE2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLE2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1303260
    GO:0005654nucleoplasm TAS--


    TLE2 for ontologies           About GeneDecksing



    TLE2 Antibody Products: 
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    Uscn Antibodies for TLE2
    Search ThermoFisher Antibodies for TLE2

    Assay Products for TLE2: 
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    Uscn ELISAs and CLIAs for TLE2

    Protein Domains /
    Families
    for TLE2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLE2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04725

    ProtoNet protein and cluster: Q04725

    3 Blocks protein families:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 6 WD repeats


    Function
    for TLE2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional
    activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members
    may be modulated by association with dominant-negative AES (By similarity)

         Genatlas biochemistry entry for TLE2:
    transducin-like enhancer of split 2,with homology to Drosophila split Groucho (Notch signaling pathway) mainly
    expressed in muscle,placenta

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): TLE2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE2
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    SwitchGear 3'UTR luciferase reporter plasmid: TLE2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLE2 (see all 7)
    OriGene shRNA RFP: TLE2
    OriGene siRNA: TLE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TLE2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TLE2 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 3): TLE2 (NM_001144762)
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    Cell Line
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    Search LifeMap BioReagents cell lines for TLE2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IDA19460168
    GO:0005515protein binding IPI17041588


    TLE2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TLE2:
     Decreased viability 


    Pathways & Interactions
    for TLE2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/9 pathways (see all 9)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		FBXW7 Mutants and NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    		Signaling by NOTCH1 in Cancer1.00
    		NOTCH1 Intracellular Domain Regulates Transcription0.65
    2Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    3Disease
    		Disease1.00
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00
    5Nanog in Mammalian ESC Pluripotency
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TLE2
        Development Notch Signaling Pathway

    1 R&D Systems Pathway for TLE2
        Wnt Signaling Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TLE2
        GSK3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TLE2
        Development Notch Signaling Pathway

    1 BioSystems Pathway for TLE2 
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    5/11        Reactome Pathways for TLE2 (see all 11)
        NOTCH1 Intracellular Domain Regulates Transcription
    Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer



    TLE2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for TLE2 (Q047251, 3 ENSP000002629534) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H3F3BP842433, ENSP000002548104I2D: score=1 STRING: ENSP00000254810
    DDB1Q165311, 3, ENSP000003017644EBI-1176061,EBI-350322 I2D: score=1 STRING: ENSP00000301764
    UTYO146073, ENSP000003289394I2D: score=3 STRING: ENSP00000328939
    RUNX1Q011963, ENSP000003003054I2D: score=2 STRING: ENSP00000300305
    EMX2Q047433, ENSP000003582024I2D: score=1 STRING: ENSP00000358202
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007165signal transduction TAS8808280
    GO:0007219Notch signaling pathway TAS--
    GO:0009887organ morphogenesis TAS8808280


    TLE2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLE2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLE2
    Search CenterWatch for drugs/clinical trials and news about TLE2 

    Transcripts
    for TLE2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLE2 gene (3 alternative transcripts): 
    NM_001144761.1  NM_001144762.1  NM_003260.4  

    Unigene Cluster for TLE2:

    Transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
    Hs.332173  [show with all ESTs]
    Unigene Representative Sequence: NM_003260
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000262953(uc002lww.3 uc010dth.3 uc010dti.3 uc010xhd.1)
    ENST00000591529 ENST00000586422 ENST00000443826 ENST00000590536 ENST00000589364
    ENST00000586492 ENST00000587672 ENST00000589205 ENST00000587217 ENST00000591457
    ENST00000590101 ENST00000587137 ENST00000590183 ENST00000589291 ENST00000592584
    ENST00000587770 ENST00000592305

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE2
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    SwitchGear 3'UTR luciferase reporter plasmid: TLE2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLE2 (see all 7)
    OriGene shRNA RFP: TLE2
    OriGene siRNA: TLE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE2
    Clone
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    Additional cDNA sequence: 

    AK123183.1 AK293407.1 AK293482.1 AK303102.1 AK308137.1 AK308608.1 AK312285.1 BC017364.2 
    M99436.1 

    11 DOTS entries:

    DT.85105456  DT.101979956  DT.95185704  DT.95207993  DT.121483837  DT.95207989  DT.100765186  DT.121483839 
    DT.121483812  DT.422720  DT.91661133 

    24/156 AceView cDNA sequences (see all 156):

    CA313714 BM931931 BU956145 BU678020 CA431711 CD245594 BM663833 CA391534 
    BM835515 CD672186 AI681385 BM789826 BU633269 H25976 BF312524 BX105520 
    AW302369 BM977785 BM850780 BM980776 CK902320 CA398012 CA391365 CA398013 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TLE2 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17a ·
    SP1:                                                                                                                                                            
    SP2:                                -     -     -     -           -           -     -                                                                           
    SP3:                                -     -     -     -           -           -     -                                                                           
    SP4:                                                                                                                                -                           
    SP5:                                -     -     -     -           -                                                                                             

    ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TLE2

    Expression
    for TLE2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGGGCCGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TLE2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb MyotomeLimb Muscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

    See TLE2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLE2

    SOURCE GeneReport for Unigene cluster: Hs.332173

    UniProtKB/Swiss-Prot: TLE2_HUMAN, Q04725
    Tissue specificity: In all tissues examined, mostly in heart, brain, and muscle

        SABiosciences Custom PCR Arrays for TLE2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE2

    Orthologs
    for TLE2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLE2 gene from 3/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 76(a)
    66(a)
    		 many ↔ many
    many ↔ many
    		 GL344313.1(393-18647)
    GL344313.1(22075-43762)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-42p8.36
    tle26
    		 si:dkey-42p8.3
    transducin-like enhancer of split 2 (E(sp1) homolo...
    		 66(a)
    61(a)
    		 possible ortholog
    possible ortholog
    		 22(21994430-22077298)
    22(21939895-21989606)
    fruit fly
    (Drosophila melanogaster)    		 Insecta gro3 neurogenesis transcription co-repressor 78(a)   3 96F10   --


    ENSEMBL Gene Tree for TLE2 (if available)
    TreeFam Gene Tree for TLE2 (if available) 

    Paralogs
    for TLE2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLE2 gene
    AES2  TLE32  TLE62  TLE42  TLE12  
    7 SIMAP similar genes for TLE2 using alignment to 8 protein entries:     TLE2_HUMAN (see all proteins):
    AES    TLE3    TLE1    TLE4    GNB5    TLE6
    WSB1

    TLE2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TLE2
    PGOHUM00000259083


    Genomic Variants
    for TLE2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1146 NCBI SNPs in TLE2 are shown (see all 1146)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1497396651,2
    		--2997146(+) ACATGG/TAGAAA 3 -- int10--------
    rs46131891,2
    		C,F,A,H,--2997153(+) GAAACC/ATTGTC 3 -- int110Minor allele frequency- A:0.16NA WA CSA 19
    rs1891656641,2
    		--2997197(+) TGGTGG/TTCCTG 3 -- int10--------
    rs1928470121,2
    		--2997217(+) CTACTC/GGGGAG 3 -- int10--------
    rs1829367411,2
    		--2997242(+) ATTGCC/TTAAGC 3 -- int10--------
    rs602036111,2
    		C,--2997276(+) GCTGAG/CATCGT 3 -- int11Minor allele frequency- C:0.50WA 2
    rs1868471881,2
    		--2997307(+) GGGAGA/GCAGAG 3 -- int10--------
    rs1476162451,2
    		--2997324(+) TGTCTC/GAAAAA 3 -- int10--------
    rs1490589701,2
    		--2997377(+) CCGTAC/TACCAT 3 -- int10--------
    rs771960391,2
    		C,F,--2997466(+) TGCCCA/TGCGCA 3 -- int12Minor allele frequency- T:0.06WA NA 238

    HapMap Linkage Disequilibrium report for TLE2 (2997636 - 3047633 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TLE2
         2 CNVs: 5071 5070
         1 Indel: 40253

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TLE2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLE2 for disorders           About GeneDecksing

    OMIM gene information: 601041    OMIM disorders: --

    3 diseases for TLE2:    About MalaCards
    spindle cell sarcoma    sarcoma    neuronitis


    Export disorders for TLE2 gene to outside databases

    Publications
    for TLE2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLE2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with TLE2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    4. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. (PubMed id 11266540)1, 2 Brantjes H.... Clevers H. (2001)
    5. Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. (PubMed id 9854018)1, 2 Grbavec D.... Stifani S. (1999)
    6. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PubMed id 9874198)1, 2 Grbavec D.... Stifani S. (1998)
    7. Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. (PubMed id 8808280)1, 3 Liu Y....Stifani S. (1996)
    8. Human homologs of a Drosophila enhancer of split gene product define a novel family of nuclear proteins. (PubMed id 1303260)1, 2 Stifani S....Artavanis-Tsakonas S. (1992)
    9. Cellular corepressor TLE2 inhibits replication-and-tr anscription- activator-mediated transactivation and lytic reactivation of Kapos i's sarcoma-associated herpesvirus. (PubMed id 19939918)1, 9 He Z....Lan K. (2010)
    10. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. (PubMed id 22304967)2 Hanson A.J....Lee E. (2012)

    External Searches for TLE2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TLE2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7089 HGNC: 11838 AceView: TLE2 Ensembl:ENSG00000065717 euGenes: HUgn7089
    ECgene: TLE2 H-InvDB: TLE2

    Other Databases showing TLE2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TLE2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLE2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TLE2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLE2 gene:
    Search GeneIP for patents involving TLE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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