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TLE1 Gene

protein-coding   GIFtS: 67
GCID: GC09M084198

Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila)

(Previous names: transducin-like enhancer of split 1, homolog of Drosophila...)
  See TLE1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila)1 2     Enhancer Of Split Groucho-Like Protein 12 3
ESG12 3 5     ESG2
Transducin-Like Enhancer Of Split 1, Homolog Of Drosophila E(Sp1)1 2     GRG12
Enhancer Of Split Groucho 11 2     Transducin-Like Enhancer Protein 12
E(Sp1) Homolog2 3     

External Ids:    HGNC: 118371   Entrez Gene: 70882   Ensembl: ENSG000001967817   OMIM: 6001895   UniProtKB: Q047243   

Export aliases for TLE1 gene to outside databases

Previous GC identifers: GC09M075257 GC09M076067 GC09M077768 GC09M079655 GC09M081428 GC09M083388 GC09M054030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TLE1 Gene:
TLE1 (transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE1 include west syndrome, and acute myeloid leukemia. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits
NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1
and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by
association with dominant-negative AES. Unusual function as coactivator for ESRRG

Gene Wiki entry for TLE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TLE1 gene promoter:
         HFH-3   STAT5A   Nkx2-5   GATA-1   MZF-1   FOXI1   POU2F1   FOXO4   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLE1 promoter sequence
   Search Chromatin IP Primers for TLE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q21.32

TLE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M084198:  view genomic region     (about GC identifiers)

Start:
84,198,598 bp from pter      End:
84,304,220 bp from pter
Size:
105,623 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 1  
Size: 770 amino acids; 83201 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY,
histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif)
3 PDB 3D structures from and Proteopedia for TLE1:
1GXR (3D)        2CE8 (3D)        2CE9 (3D)    
Secondary accessions: A8K495 Q5T3G4 Q969V9

Explore the universe of human proteins at neXtProt for TLE1: NX_Q04724

Explore proteomics data for TLE1 at MOPED

Post-translational modifications: 

  • Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest
    at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1
    or RUNX11
  • Ubiquitinated by XIAP/BIRC41
  • Ubiquitination2 at Lys30, Lys718
  • Modification sites at PhosphoSitePlus

  • See TLE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005068.2  
    ENSEMBL proteins: 
     ENSP00000365682   ENSP00000365667   ENSP00000391347   ENSP00000365646   ENSP00000365655  
    Reactome Protein details: Q04724

    TLE1 Human Recombinant Protein Products:

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    Novus Biologicals TLE1 Protein
    Novus Biologicals TLE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLE1

     
    Search eBioscience for Proteins for TLE1 

     
    antibodies-online proteins for TLE1 (2 products) 

     
    antibodies-online peptides for TLE1

    TLE1 Antibody Products:

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    antibodies-online antibodies for TLE1 (39 products) 

    TLE1 Assay Products:

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    antibodies-online kits for TLE1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04724

    ProtoNet protein and cluster: Q04724

    3 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 6 WD repeats


    Find genes that share domains with TLE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLE1_HUMAN, Q04724
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits
    NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1
    and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by
    association with dominant-negative AES. Unusual function as coactivator for ESRRG

         Genatlas biochemistry entry for TLE1:
    transducin-like enhancer of split related,with homology to Drosophila split Groucho (Notch signaling
    pathway),negative regulator of CBFA2 (AML1)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity IDA10748198
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity ----
    GO:0005515protein binding IPI10748198
    GO:0008134transcription factor binding IPI8687460
         
    Find genes that share ontologies with TLE1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TLE1:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TLE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TLE1:
    hsa-mir-423-3p (MIRT042606), hsa-mir-191-5p (MIRT021488), hsa-mir-615-3p (MIRT039611), hsa-mir-657 (MIRT007104)

    Block miRNA regulation of human, mouse, rat TLE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TLE1 (see all 11):
    hsa-miR-328 hsa-miR-300 hsa-miR-381 hsa-miR-3065-5p hsa-miR-138-2* hsa-miR-548aa hsa-miR-513b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TLE1
    Predesigned siRNA for gene silencing in human, mouse, rat TLE1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TLE1 (see all 6)
    OriGene ORF clones in mouse, rat for TLE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLE1 (NM_005077)
    Sino Biological Human cDNA Clone for TLE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TLE1_HUMAN, Q04724: Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation
    status. Hyperphosphorylation decreases the affinity for nuclear components
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with TLE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TLE1 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.64
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Signaling by GPCR
    Signal Transduction0.58
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Development Notch Signaling Pathway0.50
    5Wnt signaling pathway (KEGG)
    Wnt Signaling Pathways0.40


    Find genes that share SuperPaths with TLE1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TLE1
        Wnt Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TLE1
        GSK3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TLE1
        Development Notch Signaling Pathway

    4 BioSystems Pathways for TLE1
        Delta-Notch Signaling Pathway
    Presenilin action in Notch and Wnt signaling
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Notch-mediated HES/HEY network


    3 Reactome Pathways for TLE1
        NOTCH1 Intracellular Domain Regulates Transcription
    deactivation of the beta-catenin transactivating complex
    formation of the beta-catenin:TCF transactivating complex


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLE1: 
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TLE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TLE1 (Q047241, 2, 3 ENSP000003656824) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253704 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253704 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253704 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253704 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253704 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007165signal transduction TAS8808280
    GO:0007219Notch signaling pathway TAS--

    Find genes that share ontologies with TLE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TLE1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TLE1 gene: 
    NM_005077.3  

    Unigene Cluster for TLE1:

    Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
    Hs.197320  [show with all ESTs]
    Unigene Representative Sequence: AB209854
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376499(uc004aly.3 uc004alz.3 uc011lsr.2 uc004ama.1)
    ENST00000376484 ENST00000491534 ENST00000464999 ENST00000418319 ENST00000376463
    ENST00000376472(uc011lss.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TLE1 (see all 11):
    hsa-miR-328 hsa-miR-300 hsa-miR-381 hsa-miR-3065-5p hsa-miR-138-2* hsa-miR-548aa hsa-miR-513b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLE1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TLE1 (NM_005077)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE1
    Primer
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    OriGene qPCR primer pairs and template standards for TLE1
    OriGene qSTAR qPCR primer pairs in human, mouse for TLE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLE1
      QuantiTect SYBR Green Assays in human, mouse, rat TLE1
      QuantiFast Probe-based Assays in human, mouse, rat TLE1

    Additional mRNA sequence: 

    AB209854.1 AK290860.1 AK293606.1 AK304565.1 BC000228.1 BC010100.2 BC015747.1 M99435.1 

    19 DOTS entries:

    DT.415552  DT.100812945  DT.100761364  DT.95315139  DT.100831987  DT.91839413  DT.100751916  DT.92444336 
    DT.97867565  DT.319338  DT.91787415  DT.92444355  DT.95155152  DT.121154637  DT.91650664  DT.91901219 
    DT.99973215  DT.100730451  DT.120782093 

    Selected AceView cDNA sequences (see all 450):

    AI126735 W86409 AI739010 AA512968 N40618 CA307945 BM669965 AI142116 
    AA643385 AI184654 AA378465 AA574192 BQ879799 BM763055 BG055072 BQ932092 
    AI247357 AI266167 AW732101 AI674291 BE856258 AA434224 AW239562 BQ101088 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TLE1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ·
    SP1:                    -     -                       -                 -                                                                                       
    SP2:                    -     -                       -                 -                                                                                       
    SP3:                    -     -                       -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                      -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for TLE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TLE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCCCATT
    TLE1 Expression
    About this image


    TLE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    TLE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TLE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.197320

    UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
    Tissue specificity: In all tissues examined, mostly in brain, liver and muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TLE1: 
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Notch Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TLE1
    OriGene qSTAR qPCR primer pairs in human, mouse for TLE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TLE1
    QuantiTect SYBR Green Assays in human, mouse, rat TLE1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TLE1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tle11 , 5 transducin-like enhancer of split 1, homolog of Drosophila E(spl) less1, 5 90.32(n)1
    97.66(a)1
      4 (36.06 cM)5
    218851  NM_011599.51  NP_035729.31 
     721178055 
    chicken
    (Gallus gallus)
    Aves TLE11 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) less 85.15(n)
    98.05(a)
      427450  XM_004949181.1  XP_004949238.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLE16
    transducin-like enhancer of split 1 (E(sp1) homolo...
    96(a)
    1 ↔ 1
    2(43549048-43638452)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58242 Transcribed sequence with moderate similarity to protein pirB56695 (H.sapiens) B56695 transducin-like enhancer-of-split homolog TLE-1 - human less 82.63(n)    142022245 
    fruit fly
    (Drosophila melanogaster)
    Insecta gro3 neurogenesis transcription co-repressor 84(a)   3 96F10   --


    ENSEMBL Gene Tree for TLE1 (if available)
    TreeFam Gene Tree for TLE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TLE1 gene
    AES2  TLE32  TLE62  TLE22  TLE42  
    4 SIMAP similar genes for TLE1 using alignment to 4 protein entries:     TLE1_HUMAN (see all proteins):
    TLE4    TLE3    TLE2    AES

    Find genes that share paralogs with TLE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TLE1 (see all 2583)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409275091,2
    --54136746(+) TGTTTC/GCAATT 1 -- us2k10--------
    rs1169231551,2
    C,F--54136773(+) GACAAT/GGTAAT 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1150755401,2
    F--54136775(+) CAATGT/AAATAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs13850411,2
    C,F,A,H--54136789(-) GTCTCA/CGTGCT 1 -- us2k120Minor allele frequency- C:0.14NS EA NA 3786
    rs22771621,2
    C,F,A,H--54136827(+) CCCCAC/TAGTCT 1 -- us2k120Minor allele frequency- T:0.20EA NS NA WA CSA 3834
    rs1502011311,2
    --54136856(+) GAGCTC/GTGTGA 1 -- us2k10--------
    rs14841131,2
    C,F,A,H--54136859(-) TCTTCA/CCACAG 1 -- us2k120Minor allele frequency- C:0.16NS EA NA WA 3840
    rs1885819751,2
    --54136930(+) TTAAAA/GGGGAT 1 -- us2k10--------
    rs625785831,2
    C--84198174(+) GAGAAA/C/TGAAAG 1 -- int11WA 2
    rs2005829821,2
    C--84198174(+) AGAAC-/GAAA  
            
    GAAAG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for TLE1 (84198598 - 84304220 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TLE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2456414CNV Deletion19546169
    nsv8532CNV Loss18304495
    nsv831638CNV Loss17160897
    nsv821665CNV Loss15273396
    nsv521784CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TLE1
    DNA2.0 Custom Variant and Variant Library Synthesis for TLE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600189    OMIM disorders: --

    2 diseases for TLE1:    
    About MalaCards
    west syndrome    acute myeloid leukemia

    1 disease from the University of Copenhagen DISEASES database for TLE1:
    Synovial sarcoma

    Find genes that share disorders with TLE1           About GenesLikeMe

    2 Novoseek inferred disease relationships for TLE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 6.12 1 16510874 (1)
    tumors 0 9 19363472 (3), 19809272 (1), 18841055 (1)

    Genetic Association Database (GAD): TLE1
    Human Genome Epidemiology (HuGE) Navigator: TLE1 (2 documents)

    Export disorders for TLE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TLE1 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with TLE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3, 9 Miyasaka H.... Li S.S.-L. (Eur. J. Biochem. 1993)
    2. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PubMed id 14651967)1, 2, 9 Hentschke M. and Borgmeyer U. (Biochem. Biophys. Res. Commun. 2003)
    3. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PubMed id 9874198)1, 2, 9 Grbavec D.... Stifani S. (Eur. J. Biochem. 1998)
    4. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. (PubMed id 11731482)1, 2, 9 Dasen J.S.... Rosenfeld M.G. (Genes Dev. 2001)
    5. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PubMed id 10748198)1, 2, 9 Wang J.-C....Granner D.K. (J. Biol. Chem. 2000)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (PLoS ONE 2010)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression. (PubMed id 12397081)1, 2 Nuthall H.N.... Stifani S. (J. Biol. Chem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7088 HGNC: 11837 AceView: TLE1 Ensembl:ENSG00000196781 euGenes: HUgn7088
    ECgene: TLE1 H-InvDB: TLE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TLE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TLE1 gene:
    Search GeneIP for patents involving TLE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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