Aliases for TLE1 Gene
External Ids for TLE1 Gene
Previous GeneCards Identifiers for TLE1 Gene
GeneCards Summary for TLE1 Gene
TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include synovium cancer and core binding factor acute myeloid leukemia. Among its related pathways are Wnt / Hedgehog / Notch and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. GO annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is AES.
UniProtKB/Swiss-Prot for TLE1 Gene
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.