Aliases for TLE1 Gene
External Ids for TLE1 Gene
GeneCards Summary for TLE1 Gene
TLE1 (Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is AES.
UniProtKB/Swiss-Prot for TLE1 Gene
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.