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Aliases for TLE1 Gene

Aliases for TLE1 Gene

  • Transducin Like Enhancer Of Split 1 2 3 5
  • Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila) 2 3
  • Enhancer Of Split Groucho-Like Protein 1 3 4
  • ESG1 3 4
  • Transducin-Like Enhancer Protein 1 3
  • Enhancer Of Split Groucho 1 2
  • E(Sp1) Homolog 4
  • GRG1 3
  • ESG 3

External Ids for TLE1 Gene

Previous GeneCards Identifiers for TLE1 Gene

  • GC09M075257
  • GC09M076067
  • GC09M077768
  • GC09M079655
  • GC09M081428
  • GC09M083388
  • GC09M084198
  • GC09M054030

Summaries for TLE1 Gene

GeneCards Summary for TLE1 Gene

TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways and Presenilin action in Notch and Wnt signaling. GO annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.

UniProtKB/Swiss-Prot for TLE1 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Gene Wiki entry for TLE1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE1 Gene

Genomics for TLE1 Gene

Regulatory Elements for TLE1 Gene

Enhancers for TLE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TLE1 on UCSC Golden Path with GeneCards custom track

Promoters for TLE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLE1 Gene

Chromosome:
9
Start:
81,583,683 bp from pter
End:
81,689,535 bp from pter
Size:
105,853 bases
Orientation:
Minus strand

Genomic View for TLE1 Gene

Genes around TLE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE1 Gene

Proteins for TLE1 Gene

  • Protein details for TLE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04724-TLE1_HUMAN
    Recommended name:
    Transducin-like enhancer protein 1
    Protein Accession:
    Q04724
    Secondary Accessions:
    • A8K495
    • Q5T3G4
    • Q969V9

    Protein attributes for TLE1 Gene

    Size:
    770 amino acids
    Molecular mass:
    83201 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Interacts with SIX3. Interacts with EFNB1.

    Three dimensional structures from OCA and Proteopedia for TLE1 Gene

neXtProt entry for TLE1 Gene

Post-translational modifications for TLE1 Gene

  • Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
  • Ubiquitinated by XIAP/BIRC4.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLE1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TLE1 (TLE1)

No data available for DME Specific Peptides for TLE1 Gene

Domains & Families for TLE1 Gene

Gene Families for TLE1 Gene

Suggested Antigen Peptide Sequences for TLE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q04724

UniProtKB/Swiss-Prot:

TLE1_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
  • Contains 6 WD repeats.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with TLE1: view

Function for TLE1 Gene

Molecular function for TLE1 Gene

GENATLAS Biochemistry:
transducin-like enhancer of split related,with homology to Drosophila split Groucho (Notch signaling pathway),negative regulator of CBFA2 (AML1)
UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Gene Ontology (GO) - Molecular Function for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IDA 10748198
GO:0005515 protein binding IPI 9751710
GO:0008134 transcription factor binding IPI 8687460
GO:0042802 identical protein binding IPI 24596249
genes like me logo Genes that share ontologies with TLE1: view
genes like me logo Genes that share phenotypes with TLE1: view

Animal Model Products

CRISPR Products

miRNA for TLE1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLE1 Gene

Localization for TLE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE1 Gene

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLE1 Gene COMPARTMENTS Subcellular localization image for TLE1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IMP 22952044
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IMP 22952044
genes like me logo Genes that share ontologies with TLE1: view

Pathways & Interactions for TLE1 Gene

genes like me logo Genes that share pathways with TLE1: view

SIGNOR curated interactions for TLE1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TLE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007165 signal transduction TAS 8808280
GO:0007275 multicellular organism development TAS 8365415
GO:0009887 animal organ morphogenesis TAS 8808280
genes like me logo Genes that share ontologies with TLE1: view

Drugs & Compounds for TLE1 Gene

No Compound Related Data Available

Transcripts for TLE1 Gene

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLE1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TLE1 Gene

GeneLoc Exon Structure for
TLE1
ECgene alternative splicing isoforms for
TLE1

Expression for TLE1 Gene

mRNA expression in normal human tissues for TLE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TLE1 Gene

This gene is overexpressed in Pancreas (23.5), Peripheral blood mononuclear cells (18.8), Uterus (8.7), and Fetal testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLE1 Gene



Protein tissue co-expression partners for TLE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TLE1 Gene:

TLE1

SOURCE GeneReport for Unigene cluster for TLE1 Gene:

Hs.197320

mRNA Expression by UniProt/SwissProt for TLE1 Gene:

Q04724-TLE1_HUMAN
Tissue specificity: In all tissues examined, mostly in brain, liver and muscle.
genes like me logo Genes that share expression patterns with TLE1: view

Primer Products

No data available for mRNA differential expression in normal tissues for TLE1 Gene

Orthologs for TLE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TLE1 34
  • 92.21 (n)
  • 98.96 (a)
TLE1 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tle1 34
  • 90.32 (n)
  • 97.66 (a)
Tle1 16
Tle1 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC464546 34
  • 99.48 (n)
  • 99.61 (a)
TLE1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tle1 34
  • 90.41 (n)
  • 97.53 (a)
cow
(Bos Taurus)
Mammalia TLE1 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLE1 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves TLE1 34
  • 85.15 (n)
  • 98.05 (a)
TLE1 35
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLE1 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5824 34
tle1 34
  • 82.23 (n)
  • 95.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta gro 36
  • 84 (a)
gro 35
  • 66 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-37 36
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10712 35
  • 52 (a)
ManyToMany
CSA.8664 35
  • 56 (a)
ManyToMany
Species where no ortholog for TLE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TLE1 Gene

ENSEMBL:
Gene Tree for TLE1 (if available)
TreeFam:
Gene Tree for TLE1 (if available)

Paralogs for TLE1 Gene

Paralogs for TLE1 Gene

(4) SIMAP similar genes for TLE1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TLE1: view

Variants for TLE1 Gene

Sequence variations from dbSNP and Humsavar for TLE1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1253 -- 81,664,878(+) TATTC(A/G)TTTCT intron-variant
rs2591 -- 81,673,438(+) CAAAA(C/T)GGAAG intron-variant
rs8782 -- 81,590,945(-) CCAAC(C/T)CCGCG reference, synonymous-codon
rs10420 -- 81,584,003(+) TAGAC(A/C/G/T)AAATG utr-variant-3-prime
rs7853021 -- 81,675,708(+) TTTTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLE1 Gene

Variant ID Type Subtype PubMed ID
esv2456414 CNV deletion 19546169
esv3545005 CNV deletion 23714750
nsv1043810 CNV gain 25217958
nsv521784 CNV gain 19592680
nsv821665 CNV loss 15273396
nsv831638 CNV loss 17160897
nsv8532 CNV loss 18304495

Variation tolerance for TLE1 Gene

Residual Variation Intolerance Score: 5.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE1 Gene

Disorders for TLE1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TLE1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
synovium cancer
  • malignant tumor of synovium
core binding factor acute myeloid leukemia
  • cbf acute myeloid leukemia
spindle cell liposarcoma
sarcoma, synovial
  • synovial sarcoma
west syndrome
  • epileptic encephalopathy, early infantile, 1
- elite association - COSMIC cancer census association via MalaCards
Search TLE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TLE1

Genetic Association Database (GAD)
TLE1
Human Genome Epidemiology (HuGE) Navigator
TLE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLE1
genes like me logo Genes that share disorders with TLE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLE1 Gene

Publications for TLE1 Gene

  1. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PMID: 14651967) Hentschke M. … Borgmeyer U. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 65
  2. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. (PMID: 11731482) Dasen J.S. … Rosenfeld M.G. (Genes Dev. 2001) 3 4 22 65
  3. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PMID: 10748198) Wang J.-C. … Granner D.K. (J. Biol. Chem. 2000) 3 4 22 65
  4. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PMID: 9874198) Grbavec D. … Stifani S. (Eur. J. Biochem. 1998) 3 4 22 65
  5. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PMID: 8365415) Miyasaka H. … Li S.S.-L. (Eur. J. Biochem. 1993) 2 3 22 65

Products for TLE1 Gene

Sources for TLE1 Gene

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