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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TLE1 Gene

protein-coding   GIFtS: 66
GCID: GC09M084198

Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila)

(Previous names: transducin-like enhancer of split 1, homolog of Drosophila...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila)1 2     Enhancer Of Split Groucho-Like Protein 12 3
ESG12 3 5     ESG2
Transducin-Like Enhancer Of Split 1, Homolog Of Drosophila E(Sp1)1 2     GRG12
Enhancer Of Split Groucho 11 2     Transducin-Like Enhancer Protein 12
E(Sp1) Homolog2 3     

External Ids:    HGNC: 118371   Entrez Gene: 70882   Ensembl: ENSG000001967817   OMIM: 6001895   UniProtKB: Q047243   

Export aliases for TLE1 gene to outside databases

Previous GC identifers: GC09M075257 GC09M076067 GC09M077768 GC09M079655 GC09M081428 GC09M083388 GC09M054030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TLE1 Gene: 
TLE1 (transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)) is a protein-coding gene. Diseases associated with TLE1 include west syndrome, and synovial sarcoma, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include chromatin binding and RNA polymerase II transcription corepressor activity. An important paralog of this gene is AES.

UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits
NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1
and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by
association with dominant-negative AES. Unusual function as coactivator for ESRRG

Gene Wiki entry for TLE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLE1 gene promoter:
         HFH-3   STAT5A   Nkx2-5   GATA-1   MZF-1   FOXI1   POU2F1   FOXO4   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTLE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q21.32

TLE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M084198:  view genomic region     (about GC identifiers)

Start:
84,198,598 bp from pter      End:
84,304,220 bp from pter
Size:
105,623 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 1  
Size: 770 amino acids; 83201 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY,
histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif)
Subcellular location: Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation
status. Hyperphosphorylation decreases the affinity for nuclear components
3 PDB 3D structures from and Proteopedia for TLE1:
1GXR (3D)        2CE8 (3D)        2CE9 (3D)    
Secondary accessions: A8K495 Q5T3G4 Q969V9

Explore the universe of human proteins at neXtProt for TLE1: NX_Q04724

Explore proteomics data for TLE1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest
    at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1
    or RUNX1
  • UniProtKB: Ubiquitinated by XIAP/BIRC4
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q04724

  • TLE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TLE1 Protein Expression
    REFSEQ proteins: NP_005068.2  
    ENSEMBL proteins: 
     ENSP00000365682   ENSP00000365667   ENSP00000391347   ENSP00000365646   ENSP00000365655  
    Reactome Protein details: Q04724
    Human Recombinant Protein Products for TLE1: 
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    Novus Biologicals TLE1 Protein
    Novus Biologicals TLE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TLE1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005829cytosol IMP--

    TLE1 for ontologies           About GeneDecksing



    TLE1 Antibody Products: 
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    Abcam antibodies for TLE1
    Cloud-Clone Corp. Antibodies for TLE1 
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    LSBio Antibodies in human, mouse, rat for TLE1 

    Assay Products for TLE1: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TLE1 
    Cloud-Clone Corp. CLIAs for TLE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04724

    ProtoNet protein and cluster: Q04724

    3 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 6 WD repeats


    TLE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TLE1_HUMAN, Q04724
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits
    NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1
    and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by
    association with dominant-negative AES. Unusual function as coactivator for ESRRG

         Genatlas biochemistry entry for TLE1:
    transducin-like enhancer of split related,with homology to Drosophila split Groucho (Notch signaling
    pathway),negative regulator of CBFA2 (AML1)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity IDA10748198
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity ----
    GO:0005515protein binding IPI10748198
    GO:0008134transcription factor binding IPI8687460
         
    TLE1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TLE1:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TLE1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TLE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TLE1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TLE1 

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE1 (see all 11):
    hsa-miR-328 hsa-miR-300 hsa-miR-381 hsa-miR-3065-5p hsa-miR-138-2* hsa-miR-548aa hsa-miR-513b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLE1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for TLE1
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for TLE1
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    GenScript: all cDNA clones in your preferred vector: TLE1 (NM_005077)
    Sino Biological Human cDNA Clone for TLE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE1
    Sirion Biotech Customized lentivirus for stable overexpression of TLE1 
                         Customized lentivirus expression plasmids for stable overexpression of TLE1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLE1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TLE1 About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH0.74
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    2Nanog in Mammalian ESC Pluripotency
    GSK3 Signaling0.61
    3Signaling by GPCR
    Signal Transduction0.55
    4Development NOTCH1-mediated pathway for NF-KB activity modulation
    Development Notch Signaling Pathway0.54
    5Wnt signaling pathway
    Wnt Signaling Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TLE1
        Development Notch Signaling Pathway

    1 R&D Systems Pathway for TLE1
        Wnt Signaling Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TLE1
        GSK3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TLE1
        Development Notch Signaling Pathway

    4 BioSystems Pathways for TLE1
        Delta-Notch Signaling Pathway
    Presenilin action in Notch and Wnt signaling
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Notch-mediated HES/HEY network


    5/11        Reactome Pathways for TLE1 (see all 11)
        NOTCH1 Intracellular Domain Regulates Transcription
    Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer



    TLE1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/153 Interacting proteins for TLE1 (Q047241, 2, 3 ENSP000003656824) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253704 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253704 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253704 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253704 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253704 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007165signal transduction TAS8808280
    GO:0007219Notch signaling pathway TAS--

    TLE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLE1

    Search CenterWatch for drugs/clinical trials and news about TLE1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TLE1 gene: 
    NM_005077.3  

    Unigene Clusters for TLE1:

    Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
    Hs.197320  [show with all ESTs], Hs.689805
    Unigene Representative Sequences: AB209854, AY129016
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376499(uc004aly.3 uc004alz.3 uc011lsr.2 uc004ama.1)
    ENST00000376484 ENST00000491534 ENST00000464999 ENST00000418319 ENST00000376463
    ENST00000376472(uc011lss.1)
    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE1 (see all 11):
    hsa-miR-328 hsa-miR-300 hsa-miR-381 hsa-miR-3065-5p hsa-miR-138-2* hsa-miR-548aa hsa-miR-513b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidTLE1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TLE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLE1
    Sirion Biotech Customized lentivirus for stable overexpression of TLE1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE1

    Additional mRNA sequence: AY129016.1 

    20 DOTS entries:

    DT.415552  DT.100812945  DT.100761364  DT.95315139  DT.100831987  DT.91839413  DT.100751916  DT.92444336 
    DT.97867565  DT.319338  DT.91787415  DT.102825359  DT.92444355  DT.95155152  DT.121154637  DT.91650664 
    DT.91901219  DT.99973215  DT.100730451  DT.120782093 

    24/450 AceView cDNA sequences (see all 450):

    CK429303 AI090808 T39926 AI247357 AI142116 AA398739 AA568148 AI126735 
    BF431963 BQ879799 T61445 T29507 BE264835 W86409 AW732101 AA814833 
    AA378465 CB159079 BM700008 AI361587 AW172958 BG055072 BM996381 BX089428 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TLE1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ·
    SP1:                    -     -                       -                 -                                                                                       
    SP2:                    -     -                       -                 -                                                                                       
    SP3:                    -     -                       -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                      -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for TLE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLE1 expression in normal human tissues (normalized intensities)      TLE1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCCCATT
    TLE1 Expression
    About this image


    TLE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/atrium   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             limb/hindlimb   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon

    See TLE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLE1

    SOURCE GeneReport for Unigene clusters: Hs.197320 Hs.689805

    UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
    Tissue specificity: In all tissues examined, mostly in brain, liver and muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLE1: 
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TLE1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tle11 , 5 transducin-like enhancer of split 1, homolog of Drosophila more1, 5 90.45(n)1
    97.92(a)1
      4 (36.06 cM)5
    218851  NM_011599.41  NP_035729.31 
     721178055 
    chicken
    (Gallus gallus)
    Aves TLE11 transducin-like enhancer of split 1 (E(sp1) homolog, more 85.15(n)
    98.05(a)
      427450  XM_003643035.1  XP_003643083.1 
    lizard
    (Anolis carolinensis)
    Reptilia TLE16
    transducin-like enhancer of split 1 (E(sp1) homolo...
    96(a)
    1 ↔ 1
    2(43549048-43638452)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58242 Transcribed sequence with moderate similarity to protein more 82.63(n)    142022245 
    fruit fly
    (Drosophila melanogaster)
    Insecta gro3 neurogenesis transcription co-repressor 84(a)   3 96F10   --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-373 transducin-like enhancer protein 59(a)   I(6750588-6753388)   --


    ENSEMBL Gene Tree for TLE1 (if available)
    TreeFam Gene Tree for TLE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLE1 gene
    AES2  TLE32  TLE62  TLE22  TLE42  
    4 SIMAP similar genes for TLE1 using alignment to 4 protein entries:     TLE1_HUMAN (see all proteins):
    TLE4    TLE3    TLE2    AES

    TLE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2583 SNPs in TLE1 are shown (see all 2583)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409275091,2
    --54136746(+) TGTTTC/GCAATT 1 -- us2k10--------
    rs1169231551,2
    C,F--54136773(+) GACAAT/GGTAAT 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1150755401,2
    F--54136775(+) CAATGT/AAATAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs13850411,2
    C,F,A,H--54136789(-) GTCTCA/CGTGCT 1 -- us2k120Minor allele frequency- C:0.14NS EA NA 3786
    rs22771621,2
    C,F,A,H--54136827(+) CCCCAC/TAGTCT 1 -- us2k120Minor allele frequency- T:0.20EA NS NA WA CSA 3834
    rs1502011311,2
    --54136856(+) GAGCTC/GTGTGA 1 -- us2k10--------
    rs14841131,2
    C,F,A,H--54136859(-) TCTTCA/CCACAG 1 -- us2k120Minor allele frequency- C:0.16NS EA NA WA 3840
    rs1885819751,2
    --54136930(+) TTAAAA/GGGGAT 1 -- us2k10--------
    rs625785831,2
    C--84198174(+) GAGAAA/C/TGAAAG 1 -- int11WA 2
    rs2005829821,2
    C--84198174(+) AGAAC-/GAAA  
            
    GAAAG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for TLE1 (84198598 - 84304220 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TLE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2456414CNV Deletion19546169
    nsv8532CNV Loss18304495
    nsv831638CNV Loss17160897
    nsv821665CNV Loss15273396
    nsv521784CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600189    OMIM disorders: --

    13 diseases for TLE1:    About MalaCards
    west syndrome    synovial sarcoma    was-related disorders    crohn's disease
    acute myeloid leukemia    sarcoma    colorectal cancer    myeloid leukemia
    cerebritis    leukemia    neuronitis    hepatitis
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TLE1:
    Synovial sarcoma

    TLE1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TLE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 6.12 1 16510874 (1)
    tumors 0 9 19363472 (3), 19809272 (1), 18841055 (1)

    Genetic Association Database (GAD): TLE1
    Human Genome Epidemiology (HuGE) Navigator: TLE1 (2 documents)

    Export disorders for TLE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLE1 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with TLE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3, 9 Miyasaka H.... Li S.S.-L. (1993)
    2. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PubMed id 14651967)1, 2, 9 Hentschke M. and Borgmeyer U. (2003)
    3. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PubMed id 9874198)1, 2, 9 Grbavec D.... Stifani S. (1998)
    4. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. (PubMed id 11731482)1, 2, 9 Dasen J.S.... Rosenfeld M.G. (2001)
    5. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PubMed id 10748198)1, 2, 9 Wang J.-C....Granner D.K. (2000)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Single nucleotide polymorphisms in the Wnt and BMP pa thways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (2010)
    8. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression. (PubMed id 12397081)1, 2 Nuthall H.N.... Stifani S. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7088 HGNC: 11837 AceView: TLE1 Ensembl:ENSG00000196781 euGenes: HUgn7088
    ECgene: TLE1 H-InvDB: TLE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TLE1 gene:
    Search GeneIP for patents involving TLE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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