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GIFtS

TLE1 Gene

protein-coding   GIFtS: 64
GCID: GC09M084198

transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

(Previous names: transducin-like enhancer of split 1, homolog of Drosophila...)
 Explore 12 diseases affiliated with
TLE1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TLE1    

Aliases
for TLE1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila)1 2     E(Sp1) Homolog2 3
ESG11 2 3 5     Enhancer Of Split Groucho-Like Protein 12 3
ESG1 2     Enhancer Of Split Groucho 12
GRG11 2     Transducin-Like Enhancer Protein 12
Transducin-Like Enhancer Of Split 1, Homolog Of Drosophila E(Sp1)1 2     

External Ids:    HGNC: 118371   Entrez Gene: 70882   Ensembl: ENSG000001967817   OMIM: 6001895   UniProtKB: Q047243   

Export aliases for TLE1 gene to outside databases

Previous GC identifers: GC09M075257 GC09M076067 GC09M077768 GC09M079655 GC09M081428 GC09M083388 GC09M054030


Summaries
for TLE1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated
gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in
Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative
AES. Unusual function as coactivator for ESRRG

Gene Wiki entry for TLE1


Genomic Views
for TLE1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLE1 gene promoter:
         HFH-3   STAT5A   Nkx2-5   GATA-1   MZF-1   FOXI1   POU2F1   FOXO4   POU2F1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TLE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TLE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q21.32

TLE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLE1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M084198:  view genomic region     (about GC identifiers)

Start:
 84,198,598 bp from pter      End:
 84,304,220 bp from pter
Size:
 105,623 bases      Orientation:
 minus strand

Proteins
for TLE1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724 (See protein sequence)
Recommended Name: Transducin-like enhancer protein 1  
Size: 770 amino acids; 83201 Da
Subunit: Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY,
histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif)
Subcellular location: Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status.
Hyperphosphorylation decreases the affinity for nuclear components
3 PDB 3D structures from and Proteopedia for TLE1:
1GXR (3D)        2CE8 (3D)        2CE9 (3D)    
Secondary accessions: A8K495 Q5T3G4 Q969V9

Explore the universe of human proteins at neXtProt for TLE1: NX_Q04724

Post-translational modifications:

  • Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the
    • G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX11
  • Ubiquitinated by XIAP/BIRC41
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q04724

    • TLE1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005068.2  
    ENSEMBL proteins: 
     ENSP00000365682   ENSP00000365667   ENSP00000391347   ENSP00000365646   ENSP00000365655  
    Reactome Protein details: Q04724
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals TLE1 Protein
    Novus Biologicals TLE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TLE1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IMP--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005829cytosol IMP--


    TLE1 for ontologies           About GeneDecksing



    TLE1 Antibody Products: 
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    Uscn Antibodies for TLE1
    ThermoFisher Antibodies for TLE1

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    Uscn ELISAs and CLIAs for TLE1

    Protein Domains /
    Families
    for TLE1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TLE1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR009146 Groucho_enhance
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR005617 Groucho/TLE_N
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q04724

    ProtoNet protein and cluster: Q04724

    3 Blocks protein families:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB005617 Groucho/TLE N-terminal Q-rich domain
    IPB009146 Groucho/transducin-like enhancer protein signature


    UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
    Similarity: Belongs to the WD repeat Groucho/TLE family
    Similarity: Contains 6 WD repeats


    Function
    for TLE1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
    Function: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated
    gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in
    Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative
    AES. Unusual function as coactivator for ESRRG

         Genatlas biochemistry entry for TLE1:
    transducin-like enhancer of split related,with homology to Drosophila split Groucho (Notch signaling pathway),negative
    regulator of CBFA2 (AML1)

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE1 (see all 11):
    hsa-miR-328 hsa-miR-300 hsa-miR-381 hsa-miR-3065-5p hsa-miR-138-2* hsa-miR-548aa hsa-miR-513b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TLE1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TLE1 (see all 4)
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    OriGene siRNA: TLE1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLE1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TLE1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for TLE1

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001106RNA polymerase II transcription corepressor activity IDA10748198
    GO:0003682chromatin binding IEA--
    GO:0003714transcription corepressor activity ----
    GO:0005515protein binding IPI10748198
    GO:0008134transcription factor binding IPI8687460


    TLE1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for TLE1:
     Decreased nuclei size in G2M  Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 


    Pathways & Interactions
    for TLE1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/9 pathways (see all 9)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		FBXW7 Mutants and NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    		Signaling by NOTCH1 in Cancer1.00
    		NOTCH1 Intracellular Domain Regulates Transcription0.65
    2Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    3Disease
    		Disease1.00
    4Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00
    5Notch-mediated HES/HEY network
    		Notch-mediated HES/HEY network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TLE1
        Development Notch Signaling Pathway

    1 R&D Systems Pathway for TLE1
        Wnt Signaling Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TLE1
        GSK3 Signaling

    1 GeneGo (Thomson Reuters) Pathway for TLE1
        Development Notch Signaling Pathway

    4 BioSystems Pathways for TLE1 
        Delta-Notch Signaling Pathway
    Notch-mediated HES/HEY network
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Presenilin action in Notch and Wnt signaling

    5/11        Reactome Pathways for TLE1 (see all 11)
        NOTCH1 Intracellular Domain Regulates Transcription
    Signaling by NOTCH
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer



    TLE1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/147 Interacting proteins for TLE1 (Q047241, 2, 3 ENSP000003656824) via UniProtKB, MINT, STRING, and/or I2D (see all 147)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RUNX3Q137611, 3, ENSP000003434774EBI-711424,EBI-1046821 I2D: score=5 STRING: ENSP00000343477
    TK1P041832, 3MINT-8274214 MINT-63367 I2D: score=4 
    SMN1Q166372, 3MINT-8271586 I2D: score=2 
    SMN2Q166372, 3MINT-8271586 I2D: score=2 
    HIPK2Q9H2X62, 3MINT-60092 MINT-60093 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0007165signal transduction TAS8808280
    GO:0007219Notch signaling pathway TAS--


    TLE1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TLE1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLE1
    Search CenterWatch for drugs/clinical trials and news about TLE1 

    Transcripts
    for TLE1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TLE1 gene: 
    NM_005077.3  

    Unigene Clusters for TLE1:

    Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
    Hs.197320  [show with all ESTs], Hs.689805
    Unigene Representative Sequences: AB209854, AY129016
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376499(uc004aly.3 uc004alz.3 uc011lsr.2 uc004ama.1)
    ENST00000376484 ENST00000491534 ENST00000464999 ENST00000418319 ENST00000376463
    ENST00000376472(uc011lss.1)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TLE1
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate TLE1 (see all 11):
    hsa-miR-328 hsa-miR-300 hsa-miR-381 hsa-miR-3065-5p hsa-miR-138-2* hsa-miR-548aa hsa-miR-513b hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: TLE1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: AY129016.1 

    20 DOTS entries:

    DT.415552  DT.100812945  DT.100761364  DT.95315139  DT.100831987  DT.91839413  DT.100751916  DT.92444336 
    DT.97867565  DT.319338  DT.91787415  DT.102825359  DT.92444355  DT.95155152  DT.121154637  DT.91650664 
    DT.91901219  DT.99973215  DT.100730451  DT.120782093 

    24/450 AceView cDNA sequences (see all 450):

    AA643385 AI674291 BE018736 AI917601 AI811614 H83951 AA378465 T61445 
    T29507 AI560794 CA307945 BF431963 CB044168 BM511927 N40618 AI142116 
    AI184654 BU623409 AW172958 BM705615 BU071019 BM996381 AW239562 BE264835 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TLE1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ·
    SP1:                    -     -                       -                 -                                                                                       
    SP2:                    -     -                       -                 -                                                                                       
    SP3:                    -     -                       -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 15c ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                      -                     
    SP5:                                                            


    ECgene alternative splicing isoforms for TLE1

    Expression
    for TLE1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TLE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAGCCCATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TLE1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TLE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TLE1

    SOURCE GeneReport for Unigene clusters: Hs.197320 Hs.689805

    UniProtKB/Swiss-Prot: TLE1_HUMAN, Q04724
    Tissue specificity: In all tissues examined, mostly in brain, liver and muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including TLE1: 
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Notch Signaling Pathway in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLE1
    In Situ
    Assay Products:     
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    Orthologs
    for TLE1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TLE1 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TLE11 transducin-like enhancer of split 1 (E(sp1) homolog, more 85.15(n)
    98.05(a)    		   427450  XM_003643035.1  XP_003643083.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TLE16
    		 --
    		 96(a)
    		 1 ↔ 1
    		 2(43549976-43636365)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.58242 Transcribed sequence with moderate similarity to protein more 82.63(n)    142022245 
    fruit fly
    (Drosophila melanogaster)    		 Insecta gro3 neurogenesis transcription co-repressor 84(a)   3 96F10   --


    ENSEMBL Gene Tree for TLE1 (if available)
    TreeFam Gene Tree for TLE1 (if available) 

    Paralogs
    for TLE1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TLE1 gene
    AES2  TLE32  TLE62  TLE22  TLE42  
    5 SIMAP similar genes for TLE1 using alignment to 4 protein entries:     TLE1_HUMAN (see all proteins):
    TLE4    TLE3    TLE2    AES    TLE6

    TLE1 for paralogs           About GeneDecksing



    Genomic Variants
    for TLE1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2123 NCBI SNPs in TLE1 are shown (see all 2123)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1413063941,2
    		C,--84198170(+) AGAGA-/GAGAAC
                GAACG     		1 -- int10--------
    rs625785831,2
    		C,--84198174(+) GAGAAA/C/TGAAAG 1 -- int11WA 2
    rs2005829821,2
    		--84198174(+) AGAAC-/GAAA  
                GAAAG     		1 -- int10--------
    rs117911621,2
    		C,H,--84198215(+) GGAAGA/GGGAGA 1 -- int14Minor allele frequency- G:0.07NA EA 246
    rs1854637121,2
    		--84198301(+) CTTGAA/GTCACA 1 -- int10--------
    rs1883692341,2
    		--84198372(+) GTCATG/TAGTAA 1 -- int10--------
    rs727472151,2
    		C,--84198403(+) CCTAGT/ACTTGA 1 -- int12Minor allele frequency- A:0.05NA 122
    rs1127440441,2
    		--84198415(+) CTCCCG/AGTAAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs791570851,2
    		C--84198603(+) TTATTG/TGTACT 1 -- ut310--------
    rs8158551,2
    		C,H--84198793(-) TGCCCA/CAGTGT 1 -- ut31 ese35Minor allele frequency- C:0.08MN NS EA 586

    HapMap Linkage Disequilibrium report for TLE1 (84198598 - 84304220 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TLE1
         3 CNVs: 33137 100682 0305

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    Disorders / Diseases
    for TLE1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TLE1 for disorders           About GeneDecksing

    OMIM gene information: 600189    OMIM disorders: --

    12 diseases for TLE1:    About MalaCards
    synovial sarcoma    acute myeloid leukemia    west syndrome    myeloid leukemia
    was-related disorders    colorectal cancer    crohn's disease    sarcoma
    leukemia    cerebritis    hepatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TLE1:
    Synovial sarcoma

    2 Novoseek disease relationships for TLE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 6.12 1 16510874 (1)
    tumors 0 9 19363472 (3), 19809272 (1), 18841055 (1)

    Human Genome Epidemiology (HuGE) Navigator: TLE1 (2 documents)

    Export disorders for TLE1 gene to outside databases

    Publications
    for TLE1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TLE1 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with TLE1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. (PubMed id 8365415)1, 3, 9 Miyasaka H.... Li S.S.-L. (1993)
    2. Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. (PubMed id 14651967)1, 2, 9 Hentschke M. and Borgmeyer U. (2003)
    3. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. (PubMed id 9874198)1, 2, 9 Grbavec D.... Stifani S. (1998)
    4. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. (PubMed id 11731482)1, 2, 9 Dasen J.S.... Rosenfeld M.G. (2001)
    5. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. (PubMed id 10748198)1, 2, 9 Wang J.-C....Granner D.K. (2000)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A role for cell cycle-regulated phosphorylation in Groucho-mediated transcriptional repression. (PubMed id 12397081)1, 2 Nuthall H.N.... Stifani S. (2002)
    9. Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. (PubMed id 12057191)1, 2 Pickles L.M.... Pearl L.H. (2002)
    10. Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho- related protein lacking WD40 repeats. (PubMed id 10660609)1, 2 Tetsuka T.... Okamoto T. (2000)

    External Searches for TLE1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TLE1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7088 HGNC: 11837 AceView: TLE1 Ensembl:ENSG00000196781 euGenes: HUgn7088
    ECgene: TLE1 H-InvDB: TLE1

    Other Databases showing TLE1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TLE1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TLE1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TLE1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TLE1 gene:
    Search GeneIP for patents involving TLE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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