TLDC2 Gene
protein-coding GIFtS: 32
GCID: GC20P035505
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TBC/LysM-Associated Domain Containing 2(Previous name: chromosome 20 open reading frame 118)
(Previous symbol: C20orf118)
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Aliases
for TLDC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| TBC/LysM-Associated Domain Containing 21 2 | | Chromosome 20 Open Reading Frame 1181 | | C20orf1181 2 | | Hypothetical Protein LOC1407111 | | TLD Domain Containing 21 2 | | dJ132F21.22 | | TBC/LysM-Associated Domain-Containing Protein 22 3 | | TLD Domain-Containing Protein 22 |
Export aliases for TLDC2 gene to outside databases |
Summaries
for TLDC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for TLDC2 Gene: 
TLDC2 (TBC/LysM-associated domain containing 2) is a protein-coding gene. An important paralog of this gene is TLDC1.
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Genomic Views
for TLDC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.2 NT_011362.10
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TLDC2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TLDC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLDC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23TLDC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P035505: view genomic region
(about GC identifiers)
Start:
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35,504,524 bp from pter |
End:
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35,522,638 bp from pter |
Size:
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18,115 bases |
Orientation:
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plus strand |
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Proteins
for TLDC2 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: TLDC2_HUMAN, A0PJX2 (See
protein sequence)Recommended Name: TLD domain-containing protein 2 Size: 215 amino acids; 23912 Da
Secondary accessions: B3KVU8Explore the universe of human proteins at neXtProt for TLDC2: NX_A0PJX2
Explore proteomics data for TLDC2 at MOPED
TLDC2 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_542195.1
ENSEMBL proteins: ENSP00000473323 ENSP00000217320 ENSP00000394804
Human Recombinant Protein Products for TLDC2:
TLDC2 Antibody Products:
Assay Products for TLDC2: |
Protein
Domains /
Families
for TLDC2 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry A0PJX2 ProtoNet protein and cluster: A0PJX2 UniProtKB/Swiss-Prot: TLDC2_HUMAN, A0PJX2Similarity: Belongs to the OXR1 familySimilarity: Contains 1 TLD domain
TLDC2 for domains About GeneDecksing
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Function
for TLDC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
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Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TLDC2 | |  | Search LifeMap BioReagents cell lines for TLDC2 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLDC2 |
Pathways & Interactions
for TLDC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLDC2
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Drugs & Compounds
for TLDC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TLDC2
Search CenterWatch for drugs/clinical trials and news about TLDC2
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Transcripts
for TLDC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TLDC2 gene: NM_080628.1 Unigene Cluster for TLDC2: TBC/LysM-associated domain containing 2 Hs.472630 [show with all ESTs]Unigene Representative Sequence: AK1235443 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000602922 ENST00000217320(uc021wcz.1 uc002xgg.1) ENST00000436941
Additional mRNA sequence: AK123544.1 BC127688.1 BC130646.1 BC130648.1 4 DOTS entries: DT.406724 DT.120830714 DT.91975260 DT.75105449
GeneLoc Exon Structure
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Expression
for TLDC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See TLDC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLDC2
SOURCE GeneReport for Unigene cluster: Hs.472630
SABiosciences Custom PCR Arrays for TLDC2
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for TLDC2
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TLDC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLDC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLDC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLDC2 |
Orthologs
for TLDC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals and fungi.
Orthologs for TLDC2 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gm13321 , 5 |
predicted gene 13321, 5 |
83.81(n)1
84.91(a)1 |
|
2 (77.99 cM)5
3837661 NM_001177439.11 NP_001170910.11
1570884535 |
chicken
(Gallus gallus) |
Aves |
TLDC26 |
TBC/LysM-associated domain containing 2 |
54(a) |
1 ↔ 1 |
20(593577-597282) |
lizard
(Anolis carolinensis) |
Reptilia |
TLDC26 |
TBC/LysM-associated domain containing 2 |
56(a) |
1 ↔ 1 |
4(135120059-135134361) |
fruit fly
(Drosophila melanogaster) |
Insecta |
mtd6 |
mustard |
6(a) |
possible ortholog |
3R(1095838-1176165) |
worm
(Caenorhabditis elegans) |
Secernentea |
F52E1.136 |
Protein F52E1.13, isoform c |
9(a) |
possible ortholog |
V(8415688-8444773) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
OXR1(YPL196W)4
OXR11 |
Protein of unknown function required for normal levels more4
Oxr1p1 |
44(n)1
38(a)1 |
|
16(175043-175864)4
8559051, 4 NP_015128.11, 4 |
ENSEMBL Gene Tree for TLDC2 (if available)
TreeFam Gene Tree for TLDC2 (if available) |
Paralogs
for TLDC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TLDC2 gene
- TLDC12 OXR12 NCOA72
2 SIMAP similar genes for TLDC2 using alignment to 2 protein entries: TLDC2_HUMAN (see all proteins):C20orf118 OXR1
TLDC2 for paralogs About GeneDecksing
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Genomic Variants
for TLDC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TLDC2 (35504524 - 35522638 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for TLDC2: --
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLDC2 |
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Disorders
/ Diseases
for TLDC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TLDC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TLDC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TLDC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TLDC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TLDC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TLDC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TLDC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TLDC2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TLDC2 gene:
Search GeneIP for patents involving TLDC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TLDC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLDC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TLDC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLDC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLDC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLDC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLDC2 |
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| | | | Search Tocris compounds for TLDC2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLDC2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TLDC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLDC2 |
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