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TLDC2 Gene(Protein Coding)

TBC/LysM-Associated Domain Containing 2

GCID:
GC20P036876
GIFtS:
33
Genes Participants
UDN Logo

Aliases for TLDC2 Gene

Aliases for TLDC2 Gene

  • TBC/LysM-Associated Domain Containing 2 2 3 5
  • TBC/LysM-Associated Domain-Containing Protein 2 3 4
  • Chromosome 20 Open Reading Frame 118 2
  • Hypothetical Protein LOC140711 2
  • TLD Domain Containing 2 2
  • C20orf118 3

External Ids for TLDC2 Gene

Previous HGNC Symbols for TLDC2 Gene

  • C20orf118

Previous GeneCards Identifiers for TLDC2 Gene

  • GC20P035505

Summaries for TLDC2 Gene

GeneCards Summary for TLDC2 Gene

TLDC2 (TBC/LysM-Associated Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is NCOA7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC2 Gene

Genomics for TLDC2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for TLDC2 Gene

Enhancers for TLDC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TLDC2 on UCSC Golden Path with GeneCards custom track

Promoters for TLDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLDC2 Gene

Chromosome:
20
Start:
36,876,121 bp from pter
End:
36,894,235 bp from pter
Size:
18,115 bases
Orientation:
Plus strand

Genomic View for TLDC2 Gene

Genes around TLDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLDC2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TLDC2 Gene

Proteins for TLDC2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TLDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJX2-TLDC2_HUMAN
    Recommended name:
    TLD domain-containing protein 2
    Protein Accession:
    A0PJX2
    Secondary Accessions:
    • B3KVU8

    Protein attributes for TLDC2 Gene

    Size:
    215 amino acids
    Molecular mass:
    23912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLDC2 Gene

Proteomics data for TLDC2 Gene at MOPED

Post-translational modifications for TLDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLDC2 Gene

Domains & Families for TLDC2 Gene

Protein Domains for TLDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A0PJX2

UniProtKB/Swiss-Prot:

TLDC2_HUMAN :
  • Contains 1 TLD domain.
  • Belongs to the OXR1 family.
Domain:
  • Contains 1 TLD domain.
Family:
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with TLDC2: view

No data available for Gene Families for TLDC2 Gene

Function for TLDC2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for TLDC2 Gene

GenomeRNAi human phenotypes for TLDC2:
genes like me logo Genes that share phenotypes with TLDC2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLDC2 Gene

Localization for TLDC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TLDC2 Gene

Pathways & Interactions for TLDC2 Gene

SuperPathways for TLDC2 Gene

PathCards logoMore details on SuperPathways for TLDC2
No Data Available

Interacting Proteins for TLDC2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000217320%0d%0a9606.ENSP00000256031%0d%0a9606.ENSP00000327214%0d%0a9606.ENSP00000341942%0d%0a9606.ENSP00000339182%0d%0a
Selected Interacting proteins: ENSP00000217320 for TLDC2 Gene via STRING

Gene Ontology (GO) - Biological Process for TLDC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TLDC2 Gene

Drugs & Compounds for TLDC2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for TLDC2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for TLDC2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLDC2 Gene

TBC/LysM-associated domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC2 Gene

No ASD Table

Relevant External Links for TLDC2 Gene

GeneLoc Exon Structure for
TLDC2
ECgene alternative splicing isoforms for
TLDC2

Expression for TLDC2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for TLDC2 Gene

mRNA expression in normal human tissues for TLDC2 Gene
mRNA expression by GTEx for TLDC2 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC2 Gene

This gene is overexpressed in Colon - Transverse (x15.3), Small Intestine - Terminal Ileum (x13.4), and Kidney - Cortex (x7.0).

SOURCE GeneReport for Unigene cluster for TLDC2 Gene Hs.472630

genes like me logo Genes that share expression patterns with TLDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TLDC2 Gene

Orthologs for TLDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLDC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia TLDC2 35
  • 86.05 (n)
  • 84.19 (a)
TLDC2 36
  • 83 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia TLDC2 35
  • 84.81 (n)
  • 83.72 (a)
TLDC2 36
  • 81 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Tldc2 35
  • 82.08 (n)
  • 82.55 (a)
Tldc2 16
Tldc2 36
  • 84 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia TLDC2 35
  • 99.69 (n)
  • 100 (a)
TLDC2 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Tldc2 35
  • 83.02 (n)
  • 81.9 (a)
oppossum
(Monodelphis domestica)
 Mammalia TLDC2 36
  • 70 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia TLDC2 36
  • 75 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves TLDC2 35
  • 66.27 (n)
  • 59.88 (a)
TLDC2 36
  • 54 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TLDC2 36
  • 56 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tldc2 35
  • 57.05 (n)
  • 47.91 (a)
zebrafish
(Danio rerio)
 Actinopterygii TLDC2 36
  • 13 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta mtd 36
  • 7 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea lmd-3 36
  • 9 (a)
 OneToOne
A. gosspyii yeast
(Ashbya gossypii)
 Saccharomycetes AGOS_AFL078W 35
  • 51.57 (n)
  • 38.99 (a)
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0E19449g 35
  • 45.56 (n)
  • 39.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes OXR1 35
  • 43.33 (n)
  • 38 (a)
OXR1 38
bread mold
(Neurospora crassa)
 Ascomycetes NCU02394 35
  • 44.33 (n)
  • 31.96 (a)
Species with no ortholog for TLDC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC2 Gene

ENSEMBL:
Gene Tree for TLDC2 (if available)
TreeFam:
Gene Tree for TLDC2 (if available)

Paralogs for TLDC2 Gene

Paralogs for TLDC2 Gene

(3) SIMAP similar genes for TLDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLDC2: view

Variants for TLDC2 Gene

Sequence variations from dbSNP and Humsavar for TLDC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3748460 - 36,879,155(+) GCAGC(A/G)GGCCA reference, missense
rs1024191 -- 36,879,632(+) aggag(A/T)tcaag intron-variant
rs1063121 -- 36,890,397(-) GAAAG(A/G)GAAAG intron-variant, utr-variant-3-prime
rs1129213 -- 36,890,602(-) ttgta(A/G)tccca intron-variant, utr-variant-3-prime
rs1129218 -- 36,890,476(-) AAACA(A/G)AAAGA intron-variant, utr-variant-3-prime

Variation tolerance for TLDC2 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TLDC2 Gene

Disorders for TLDC2 Gene

Relevant External Links for TLDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLDC2

No disorders were found for TLDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC2 Gene

Publications for TLDC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TLDC2 Gene

Sources for TLDC2 Gene

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