Aliases for TLDC2 Gene
Aliases for TLDC2 Gene
External Ids for TLDC2 Gene
- HGNC: 16112
- Entrez Gene: 140711
- Ensembl: ENSG00000101342
- UniProtKB: A0PJX2
Previous HGNC Symbols for TLDC2 Gene
- C20orf118
Previous GeneCards Identifiers for TLDC2 Gene
- GC20P035505
Summaries for TLDC2 Gene
GeneCards Summary for TLDC2 Gene
TLDC2 (TBC/LysM-Associated Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is OXR1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC2 Gene
Genomics for TLDC2 Gene
GeneHancer (GH) Regulatory Elements for TLDC2 Gene
Promoters and enhancers for TLDC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TLDC2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TLDC2 Gene
Genomic Locations for TLDC2 Gene
- chr20:36,876,121-36,894,235
- (GRCh38/hg38)
- Size:
- 18,115 bases
- Orientation:
- Plus strand
- chr20:35,504,524-35,522,638
- (GRCh37/hg19)
Genomic View for TLDC2 Gene
Genes around TLDC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by Ensembl
- 20q11.23 by Entrez Gene
- 20q11.23 by HGNC
TLDC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for TLDC2 Gene
Proteins for TLDC2 Gene
-
Protein details for TLDC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A0PJX2-TLDC2_HUMAN
- Recommended name:
- TLD domain-containing protein 2
- Protein Accession:
- A0PJX2
- B3KVU8
Protein attributes for TLDC2 Gene
- Size:
- 215 amino acids
- Molecular mass:
- 23912 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TLDC2 Gene
No Post-translational modifications
Other Protein References for TLDC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TLDC2
- Novus Biologicals Antibodies for TLDC2
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Protein Products
-
OriGene Purified Proteins for TLDC2
- Search Origene for MassSpec and Protein Over-expression Lysates for TLDC2
- Origene Custom Protein Services for TLDC2
- Novus Biologicals proteins for TLDC2
- Search GeneTex for Proteins for TLDC2
Assay Products
No data available for DME Specific Peptides for TLDC2 Gene
Domains & Families for TLDC2 Gene
Gene Families for TLDC2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for TLDC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
A0PJX2- Family:
-
- Belongs to the OXR1 family.
Function for TLDC2 Gene
Phenotypes for TLDC2 Gene
- GenomeRNAi human phenotypes for TLDC2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLDC2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TLDC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLDC2 gene
- Search ViGene Biosciences for TLDC2
CRISPR Products
-
OriGene CRISPR knockouts for TLDC2
- genomics-online: gRNA clones - Search results for available TLDC2 gene related products
- Applied Biological Materials CRISPR for TLDC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLDC2
- GenScript: Design CRISPR guide RNA sequences for TLDC2
miRNA Products
- Search ViGene Biosciences for TLDC2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TLDC2
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- genomics-online: shRNA clones - Search results for available TLDC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLDC2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TLDC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLDC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TLDC2 gene related products
- orf clones - Search results for available TLDC2 gene related products
- Applied Biological Materials Clones for TLDC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TLDC2
-
ViGene Biosciences adenoviral particle packaged cDNA for TLDC2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TLDC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLDC2 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLDC2 Gene
Localization for TLDC2 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TLDC2 Gene
Pathways & Interactions for TLDC2 Gene
No Data Available
Interacting Proteins for TLDC2 Gene
No data available for Pathways by source and SIGNOR curated interactions for TLDC2 Gene
Transcripts for TLDC2 Gene
mRNA/cDNA for TLDC2 Gene
- (5) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TLDC2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TLDC2
- genomics-online: gRNA clones - Search results for available TLDC2 gene related products
- Applied Biological Materials CRISPR for TLDC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLDC2
- GenScript: Design CRISPR guide RNA sequences for TLDC2
miRNA Products
- Search ViGene Biosciences for TLDC2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TLDC2
- Browse OriGene Inhibitory RNA Products For TLDC2
- genomics-online: shRNA clones - Search results for available TLDC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLDC2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TLDC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLDC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available TLDC2 gene related products
- orf clones - Search results for available TLDC2 gene related products
- Applied Biological Materials Clones for TLDC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TLDC2 Gene
mRNA differential expression in normal tissues according to GTEx for TLDC2 Gene
This gene is overexpressed in Colon - Transverse (x15.3), Small Intestine - Terminal Ileum (x13.4), and Kidney - Cortex (x7.0).
NURSA nuclear receptor signaling pathways regulating expression of TLDC2 Gene:
TLDC2SOURCE GeneReport for Unigene cluster for TLDC2 Gene:
Hs.472630Primer Products
-
OriGene qPCR primer pairs for TLDC2
- genomics-online: primer clones - Search results for available TLDC2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLDC2 Gene
Orthologs for TLDC2 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TLDC2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | TLDC2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | TLDC2 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Tldc2 33 |
|
||
mouse (Mus musculus) |
Mammalia | Tldc2 33 16 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | TLDC2 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | TLDC2 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TLDC2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TLDC2 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tldc2 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | TLDC2 34 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | mtd 34 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | lmd-3 34 |
|
OneToOne | |
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFL078W 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E19449g 33 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | OXR1 33 36 |
|
||
bread mold (Neurospora crassa) |
Ascomycetes | NCU02394 33 |
|
- Species where no ortholog for TLDC2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TLDC2 Gene
Variants for TLDC2 Gene
SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs114791229 | likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome | 36,892,644(+) | T/C | genic_downstream_transcript_variant, intron_variant | |
rs115645414 | likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome | 36,892,887(+) | G/A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
rs116489517 | likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome | 36,891,924(+) | G/C | genic_downstream_transcript_variant, intron_variant | |
rs138927042 | likely-benign, Chilblain Lupus, Aicardi Goutieres syndrome | 36,892,861(+) | G/T | genic_downstream_transcript_variant, splice_acceptor_variant | |
rs143588093 | uncertain-significance, Chilblain Lupus, Aicardi Goutieres syndrome | 36,892,692(+) | C/A/T | genic_downstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3645741 | CNV | gain | 21293372 |
nsv1057845 | CNV | gain | 25217958 |
nsv585944 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.69;
57.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLDC2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TLDC2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLDC2 Gene
Disorders for TLDC2 Gene
Additional Disease Information for TLDC2
No disorders were found for TLDC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC2 Gene
Publications for TLDC2 Gene
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
Products for TLDC2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Custom Antibody ServicesOriGene Antibodies for TLDC2
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- OriGene Purified Proteins for TLDC2
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- OriGene qPCR primer pairs for TLDC2
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- Novus Biologicals Antibodies for TLDC2
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for TLDC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TLDC2
- VectorBuilder custom plasmid, inducible vectors for TLDC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TLDC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available C20ORF118 related products ranked by validation data
- antibodies-online: Search results for available C20ORF118 related products ranked by validation data
- antibodies-online: Search results for available C20ORF118 related products ranked by validation data
- Search GeneTex for Antibodies for TLDC2
- Search GeneTex for Proteins for TLDC2
- ViGene Biosciences adenoviral particle packaged cDNA for TLDC2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TLDC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TLDC2 gene
- Search ViGene Biosciences for TLDC2
- Horizon Cell Lines for TLDC2
- genomics-online: cdna clones - Search results for available C20ORF118 gene related products
- orf clones - Search results for available C20ORF118 gene related products
- genomics-online: gRNA clones - Search results for available C20ORF118 gene related products
- genomics-online: primer clones - Search results for available C20ORF118 gene related products
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Sources for TLDC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew