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Aliases for TLDC2 Gene

Aliases for TLDC2 Gene

  • TBC/LysM-Associated Domain Containing 2 2 3 5
  • TBC/LysM-Associated Domain-Containing Protein 2 3 4
  • Chromosome 20 Open Reading Frame 118 2
  • TLD Domain-Containing Protein 2 3
  • Hypothetical Protein LOC140711 2
  • TLD Domain Containing 2 2
  • C20orf118 3

External Ids for TLDC2 Gene

Previous HGNC Symbols for TLDC2 Gene

  • C20orf118

Previous GeneCards Identifiers for TLDC2 Gene

  • GC20P035505

Summaries for TLDC2 Gene

GeneCards Summary for TLDC2 Gene

TLDC2 (TBC/LysM-Associated Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is OXR1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC2 Gene

Genomics for TLDC2 Gene

Regulatory Elements for TLDC2 Gene

Enhancers for TLDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G036459 1.7 Ensembl ENCODE dbSUPER 12.5 -409.4 -409358 13.6 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 RBM12 CPNE1 AAR2 RBL1 TGIF2 RPL36P4 TLDC2 MYL9 PIR36954 GC20P036463
GH20G036540 1.5 FANTOM5 ENCODE dbSUPER 12.5 -333.2 -333155 5.3 HDGF SIN3A YY1 TCF12 ZNF121 GLIS2 GATA2 ELK1 FOS ZNF263 RBM12 CPNE1 MYL9 RPL36P4 TLDC2 AAR2 TGIF2 RBL1 DLGAP4 GC20P036550
GH20G037142 1.1 ENCODE 12.5 +266.8 266802 1.3 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 AAR2 RBL1 TLDC2 TGIF2 RPN2 MROH8 MANBAL RPRD1B TTI1 LOC100419562
GH20G036881 1.1 ENCODE dbSUPER 5.8 +6.0 5989 1.4 HDGF CTCF PKNOX1 SAP130 INSM2 FOSL1 ZFHX2 FOS ZNF600 PRDM10 TLDC2 MROH8 SAMHD1
GH20G036941 0.9 ENCODE dbSUPER 6 +65.6 65585 1.0 HDAC1 PKNOX1 ZBTB40 ZNF664 FOSL1 PRDM6 ATF3 GATA2 PBX2 HMBOX1 TLDC2 SAMHD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TLDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLDC2 Gene

Chromosome:
20
Start:
36,876,121 bp from pter
End:
36,894,235 bp from pter
Size:
18,115 bases
Orientation:
Plus strand

Genomic View for TLDC2 Gene

Genes around TLDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLDC2 Gene

Proteins for TLDC2 Gene

  • Protein details for TLDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJX2-TLDC2_HUMAN
    Recommended name:
    TLD domain-containing protein 2
    Protein Accession:
    A0PJX2
    Secondary Accessions:
    • B3KVU8

    Protein attributes for TLDC2 Gene

    Size:
    215 amino acids
    Molecular mass:
    23912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLDC2 Gene

Post-translational modifications for TLDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLDC2 Gene

No data available for DME Specific Peptides for TLDC2 Gene

Domains & Families for TLDC2 Gene

Protein Domains for TLDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLDC2 Gene

Graphical View of Domain Structure for InterPro Entry

A0PJX2

UniProtKB/Swiss-Prot:

TLDC2_HUMAN :
  • Belongs to the OXR1 family.
Family:
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with TLDC2: view

No data available for Gene Families for TLDC2 Gene

Function for TLDC2 Gene

Phenotypes for TLDC2 Gene

genes like me logo Genes that share phenotypes with TLDC2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLDC2 Gene

Localization for TLDC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLDC2 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TLDC2 Gene

Pathways & Interactions for TLDC2 Gene

SuperPathways for TLDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TLDC2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TLDC2 Gene

Drugs & Compounds for TLDC2 Gene

No Compound Related Data Available

Transcripts for TLDC2 Gene

mRNA/cDNA for TLDC2 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLDC2 Gene

TBC/LysM-associated domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC2 Gene

No ASD Table

Relevant External Links for TLDC2 Gene

GeneLoc Exon Structure for
TLDC2
ECgene alternative splicing isoforms for
TLDC2

Expression for TLDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLDC2 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC2 Gene

This gene is overexpressed in Colon - Transverse (x15.3), Small Intestine - Terminal Ileum (x13.4), and Kidney - Cortex (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of TLDC2 Gene:

TLDC2

SOURCE GeneReport for Unigene cluster for TLDC2 Gene:

Hs.472630
genes like me logo Genes that share expression patterns with TLDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLDC2 Gene

Orthologs for TLDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLDC2 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia TLDC2 34 35
  • 86.05 (n)
dog
(Canis familiaris)
Mammalia TLDC2 34 35
  • 84.81 (n)
rat
(Rattus norvegicus)
Mammalia Tldc2 34
  • 83.02 (n)
mouse
(Mus musculus)
Mammalia Tldc2 34 16 35
  • 82.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TLDC2 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLDC2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLDC2 34 35
  • 66.27 (n)
lizard
(Anolis carolinensis)
Reptilia TLDC2 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tldc2 34
  • 57.05 (n)
zebrafish
(Danio rerio)
Actinopterygii TLDC2 35
  • 13 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mtd 35
  • 7 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lmd-3 35
  • 9 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL078W 34
  • 51.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19449g 34
  • 45.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OXR1 34 37
  • 43.33 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02394 34
  • 44.33 (n)
Species where no ortholog for TLDC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC2 Gene

ENSEMBL:
Gene Tree for TLDC2 (if available)
TreeFam:
Gene Tree for TLDC2 (if available)

Paralogs for TLDC2 Gene

Paralogs for TLDC2 Gene

(3) SIMAP similar genes for TLDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLDC2: view

Variants for TLDC2 Gene

Sequence variations from dbSNP and Humsavar for TLDC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs114791229 Likely benign 36,892,644(+) AAAAA(C/T)AGAGT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs115645414 Likely benign 36,892,887(+) TAAAT(A/C/G)AATTG utr-variant-3-prime
rs116489517 Likely benign 36,891,924(+) TCTGA(C/G)GATGA intron-variant, utr-variant-3-prime
rs138927042 Likely benign 36,892,861(+) TTGCA(G/T)AATTC utr-variant-3-prime, splice-acceptor-variant
rs147220022 Likely benign 36,892,837(+) ATTAA(A/G)GCATG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TLDC2 Gene

Variant ID Type Subtype PubMed ID
esv3645741 CNV gain 21293372
nsv1057845 CNV gain 25217958
nsv585944 CNV loss 21841781

Variation tolerance for TLDC2 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLDC2 Gene

Disorders for TLDC2 Gene

Relevant External Links for TLDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLDC2

No disorders were found for TLDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC2 Gene

Publications for TLDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TLDC2 Gene

Sources for TLDC2 Gene

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