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TLDC2 Gene

protein-coding   GIFtS: 31
GCID: GC20P035505

TBC/LysM-Associated Domain Containing 2

(Previous name: chromosome 20 open reading frame 118)
(Previous symbol: C20orf118)
  Search for TLDC2
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TBC/LysM-Associated Domain Containing 21 2     Chromosome 20 Open Reading Frame 1181
C20orf1181 2     Hypothetical Protein LOC1407111
TLD Domain Containing 21 2     dJ132F21.22
TBC/LysM-Associated Domain-Containing Protein 22 3     TLD Domain-Containing Protein 22

External Ids:    HGNC: 161121   Entrez Gene: 1407112   Ensembl: ENSG000001013427   UniProtKB: A0PJX23   

Export aliases for TLDC2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TLDC2 Gene:
TLDC2 (TBC/LysM-associated domain containing 2) is a protein-coding gene. An important paralog of this gene is TLDC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TLDC2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

TLDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLDC2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P035505:  view genomic region     (about GC identifiers)

Start:
35,504,524 bp from pter      End:
35,522,638 bp from pter
Size:
18,115 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TLDC2_HUMAN, A0PJX2 (See protein sequence)
Recommended Name: TLD domain-containing protein 2  
Size: 215 amino acids; 23912 Da
Secondary accessions: B3KVU8

Explore the universe of human proteins at neXtProt for TLDC2: NX_A0PJX2

Explore proteomics data for TLDC2 at MOPED


See TLDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_542195.1  
ENSEMBL proteins: 
 ENSP00000473323   ENSP00000217320   ENSP00000394804  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR006571 TLDc

Graphical View of Domain Structure for InterPro Entry A0PJX2

ProtoNet protein and cluster: A0PJX2

UniProtKB/Swiss-Prot: TLDC2_HUMAN, A0PJX2
Similarity: Belongs to the OXR1 family
Similarity: Contains 1 TLD domain


Find genes that share domains with TLDC2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TLDC2
Interactions:

    Search GeneGlobe Interaction Network for TLDC2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TLDC2 (ENSP000002173204) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
KLHDC3ENSP000003139954STRING: ENSP00000313995
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TLDC2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TLDC2 gene: 
NM_080628.1  

Unigene Cluster for TLDC2:

TBC/LysM-associated domain containing 2
Hs.472630  [show with all ESTs]
Unigene Representative Sequence: AK123544
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000602922 ENST00000217320(uc021wcz.1 uc002xgg.1) ENST00000436941

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Additional mRNA sequence: 

AK123544.1 BC127688.1 BC130646.1 BC130648.1 

4 DOTS entries:

DT.406724  DT.120830714  DT.91975260  DT.75105449 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TLDC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TLDC2 Expression
About this image

TLDC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TLDC2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.472630
    Custom PCR Arrays for TLDC2
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for TLDC2 gene from Selected species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm13325
Tldc21
predicted gene 13325
TBC/LysM associated domain containing 21
82.08(n)1
82.55(a)1
  2 (77.99 cM)5
3837661  NM_001177439.11  NP_001170910.11 
 1570884535 
chicken
(Gallus gallus)
Aves TLDC21 TBC/LysM-associated domain containing 2 66.27(n)
59.88(a)
  101747236  XM_004946933.1  XP_004946990.1 
lizard
(Anolis carolinensis)
Reptilia TLDC26
TBC/LysM-associated domain containing 2
56(a)
1 ↔ 1
4(135120059-135134361)
tropical clawed frog
(Xenopus tropicalis)
Amphibia tldc21 TBC/LysM-associated domain containing 2 57.05(n)
47.91(a)
  100493022  XM_002942284.2  XP_002942330.1 
zebrafish
(Danio rerio)
Actinopterygii TLDC26
TBC/LysM-associated domain containing 2
13(a)
1 ↔ 1
17(24523751-24546082) ENSDARG00000063511
fruit fly
(Drosophila melanogaster)
Insecta mtd6
mustard
7(a)
1 ↔ 1
3R(1095838-1176165)
worm
(Caenorhabditis elegans)
Secernentea lmd-36
Protein F52E1.13, isoform c (F52E1.13) mRNA, compl...
9(a)
1 ↔ 1
V(8415688-8444773) WBGene00018700
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OXR1(YPL196W)4
OXR11
Protein of unknown function required for normal levels more4
OXR11
43.33(n)1
38(a)1
  16(175043-175864)4
8559051, 4  NP_015128.11, 4 


ENSEMBL Gene Tree for TLDC2 (if available)
TreeFam Gene Tree for TLDC2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TLDC2 gene
TLDC12  OXR12  NCOA72  
3 SIMAP similar genes for TLDC2 using alignment to 2 protein entries:     TLDC2_HUMAN (see all proteins):
C20orf118    OXR1    NCOA7

Find genes that share paralogs with TLDC2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TLDC2 (see all 451)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs60166261,2
--35502605(+) accagC/Tctgac 1 -- us2k10--------
rs60298601,2
--35502616(+) caacaC/Tggaga 1 -- us2k10--------
rs1812220761,2
--35502669(+) TGGCAC/TGCACC 1 -- us2k10--------
rs1145305611,2
C,F--35502926(+) TTATAT/CTCTTA 1 -- us2k11Minor allele frequency- C:0.03WA 118
rs60298631,2
C,H--35502940(+) ttttcC/Tggttt 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
rs797479331,2
C--35502948(+) TTTCTA/CAAATT 1 -- us2k10--------
rs1862064511,2
--35503006(+) GGGCCA/GGGCCC 1 -- us2k10--------
rs1919547371,2
--35503021(+) GCTCAC/TGCCTG 1 -- us2k10--------
rs1816408431,2
--35503174(+) GAACCC/TGGGAG 1 -- us2k10--------
rs12911181,2
C,F,A--35503181(+) ggaggG/Cagagg 1 -- us2k11Minor allele frequency- C:0.50NA 2

HapMap Linkage Disequilibrium report for TLDC2 (35504524 - 35522638 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TLDC2: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TLDC2
DNA2.0 Custom Variant and Variant Library Synthesis for TLDC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TLDC2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TLDC2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 140711 HGNC: 16112 Ensembl:ENSG00000101342 euGenes: HUgn140711 ECgene: TLDC2
H-InvDB: TLDC2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TLDC2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TLDC2 gene:
Search GeneIP for patents involving TLDC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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