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TLDC2 Gene

protein-coding GIFtS: 31
GCID: GC20P035505

TBC/LysM-Associated Domain Containing 2

(Previous name: chromosome 20 open reading frame 118)
(Previous symbol: C20orf118)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
TBC/LysM-Associated Domain Containing 2¹ ²		Chromosome 20 Open Reading Frame 118¹
C20orf118¹ ²		Hypothetical Protein LOC140711¹
TLD Domain Containing 2¹ ²		dJ132F21.2²
TBC/LysM-Associated Domain-Containing Protein 2² ³		TLD Domain-Containing Protein 2²

External Ids:	HGNC: 16112¹	Entrez Gene: 140711²	Ensembl: ENSG00000101342⁷	UniProtKB: A0PJX2³

Export aliases for TLDC2 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TLDC2 Gene:

TLDC2 (TBC/LysM-associated domain containing 2) is a protein-coding gene. An important paralog of this gene is TLDC1.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000020.10 NC_018931.2 NT_011362.11

Regulatory elements:

Search for regulatory transcription factor binding sites for TLDC2
Other transcription factors

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TLDC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23

TLDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLDC2 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P035505: view genomic region (about GC identifiers)

Start:	35,504,524 bp from pter	End:	35,522,638 bp from pter
Size:	18,115 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: TLDC2_HUMAN, A0PJX2 (See protein sequence)

Recommended Name: TLD domain-containing protein 2

Size: 215 amino acids; 23912 Da

Secondary accessions: B3KVU8

Explore the universe of human proteins at neXtProt for TLDC2: NX_A0PJX2

Explore proteomics data for TLDC2 at MOPED

See TLDC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_542195.1

ENSEMBL proteins:

ENSP00000473323 ENSP00000217320 ENSP00000394804

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR006571 TLDc

Graphical View of Domain Structure for InterPro Entry A0PJX2

ProtoNet protein and cluster: A0PJX2

UniProtKB/Swiss-Prot: TLDC2_HUMAN, A0PJX2

Similarity: Belongs to the OXR1 family

Similarity: Contains 1 TLD domain

Find genes that share domains with TLDC2 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TLDC2
Interactions:

Search GeneGlobe Interaction Network for TLDC2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TLDC2 (ENSP00000217320⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
KLHDC3	ENSP00000313995⁴	STRING: ENSP00000313995

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TLDC2 gene:

NM_080628.1

Unigene Cluster for TLDC2:

TBC/LysM-associated domain containing 2

Hs.472630 [show with all ESTs]

Unigene Representative Sequence: AK123544

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000602922 ENST00000217320(uc021wcz.1 uc002xgg.1) ENST00000436941

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Additional mRNA sequence:

AK123544.1 BC127688.1 BC130646.1 BC130648.1

4 DOTS entries:

DT.406724 DT.120830714 DT.91975260 DT.75105449

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TLDC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TLDC2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TLDC2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.472630

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for TLDC2 gene from Selected species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Gm1332⁵ Tldc2¹	predicted gene 1332⁵ TBC/LysM associated domain containing 2¹	82.08(n)¹ 82.55(a)¹		2 (77.99 cM)⁵ 383766¹ NM_001177439.1¹ NP_001170910.1¹ 157088453⁵
chicken (Gallus gallus)	Aves	TLDC2¹	TBC/LysM-associated domain containing 2	66.27(n) 59.88(a)		101747236 XM_004946933.1 XP_004946990.1
lizard (Anolis carolinensis)	Reptilia	TLDC2⁶	TBC/LysM-associated domain containing 2	56(a)	1 ↔ 1	4(135120059-135134361)
tropical clawed frog (Xenopus tropicalis)	Amphibia	tldc2¹	TBC/LysM-associated domain containing 2	57.05(n) 47.91(a)		100493022 XM_002942284.2 XP_002942330.1
zebrafish (Danio rerio)	Actinopterygii	TLDC2⁶	TBC/LysM-associated domain containing 2	13(a)	1 ↔ 1	17(24523751-24546082) ENSDARG00000063511
fruit fly (Drosophila melanogaster)	Insecta	mtd⁶	mustard	7(a)	1 ↔ 1	3R(1095838-1176165)
worm (Caenorhabditis elegans)	Secernentea	lmd-3⁶	Protein F52E1.13, isoform c (F52E1.13) mRNA, compl...	9(a)	1 ↔ 1	V(8415688-8444773) WBGene00018700
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	OXR1(YPL196W)⁴ OXR1¹	Protein of unknown function required for normal levels more⁴ OXR1¹	43.33(n)¹ 38(a)¹		16(175043-175864)⁴ 855905^{1, 4} NP_015128.1^{1, 4}

ENSEMBL Gene Tree for TLDC2 (if available)
TreeFam Gene Tree for TLDC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TLDC2 gene

TLDC1² OXR1² NCOA7²

3 SIMAP similar genes for TLDC2 using alignment to 2 protein entries: TLDC2_HUMAN (see all proteins):

C20orf118 OXR1 NCOA7

Find genes that share paralogs with TLDC2 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6016626^1,2		--	35502605(+)	`accagC/Tctgac`	1	--	us2k¹		0	--	--	--	--
rs6029860^1,2		--	35502616(+)	`caacaC/Tggaga`	1	--	us2k¹		0	--	--	--	--
rs181222076^1,2		--	35502669(+)	`TGGCAC/TGCACC`	1	--	us2k¹		0	--	--	--	--
rs114530561^1,2	C,F	--	35502926(+)	`TTATAT/CTCTTA`	1	--	us2k¹		1		WA	118
rs6029863^1,2	C,H	--	35502940(+)	`ttttcC/Tggttt`	1	--	us2k¹		4		NS EA	420
rs79747933^1,2	C	--	35502948(+)	`TTTCTA/CAAATT`	1	--	us2k¹		0	--	--	--	--
rs186206451^1,2		--	35503006(+)	`GGGCCA/GGGCCC`	1	--	us2k¹		0	--	--	--	--
rs191954737^1,2		--	35503021(+)	`GCTCAC/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs181640843^1,2		--	35503174(+)	`GAACCC/TGGGAG`	1	--	us2k¹		0	--	--	--	--
rs1291118^1,2	C,F,A	--	35503181(+)	`ggaggG/Cagagg`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for TLDC2 (35504524 - 35522638 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for TLDC2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TLDC2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TLDC2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 140711	HGNC: 16112	Ensembl:ENSG00000101342	euGenes: HUgn140711	ECgene: TLDC2
H-InvDB: TLDC2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TLDC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TLDC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TLDC2 gene:
Search GeneIP for patents involving TLDC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TLDC2 gene at Home site.

Version: 3.12.304 29 Jan 2015
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TLDC2 Gene

TBC/LysM-Associated Domain Containing 2

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Export list of displayed genes

TLDC2 Gene

TBC/LysM-Associated Domain Containing 2

Aliasesfor TLDC2 gene

Summariesfor TLDC2 gene

Genomic Viewsfor TLDC2 gene

Proteinsfor TLDC2 gene

TLDC2 Human Recombinant Protein Products:

TLDC2 Antibody Products:

TLDC2 Assay Products:

Domains /Familiesfor TLDC2 gene

Functionfor TLDC2 gene

Localizationfor TLDC2 gene

Pathways & Interactionsfor TLDC2 gene

Drugs & Compoundsfor TLDC2 gene

Transcriptsfor TLDC2 gene

Expression for TLDC2 gene

Orthologsfor TLDC2 gene

Paralogsfor TLDC2 gene

Genomic Variantsfor TLDC2 gene

Disorders / Diseasesfor TLDC2 gene

Publicationsfor TLDC2 gene

External Searches for TLDC2 gene

Genome Databases showing TLDC2 gene

Other Databases showing TLDC2 gene

Specialized Databases showing TLDC2 gene

Intellectual Propertyfor TLDC2 gene

Productsfor TLDC2 gene

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Aliases
for TLDC2 gene

Summaries
for TLDC2 gene

Genomic Views
for TLDC2 gene

Proteins
for TLDC2 gene

Domains /
Families
for TLDC2 gene

Function
for TLDC2 gene

Localization
for TLDC2 gene

Pathways & Interactions
for TLDC2 gene

Drugs & Compounds
for TLDC2 gene

Transcripts
for TLDC2 gene

Expression
for TLDC2 gene

Orthologs
for TLDC2 gene

Paralogs
for TLDC2 gene

Genomic Variants
for TLDC2 gene

Disorders / Diseases
for TLDC2 gene

Publications
for TLDC2 gene

Intellectual Property
for TLDC2 gene

Products
for TLDC2 gene