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Aliases for TLDC2 Gene

Aliases for TLDC2 Gene

  • TBC/LysM-Associated Domain Containing 2 2 3 5
  • TBC/LysM-Associated Domain-Containing Protein 2 3 4
  • Chromosome 20 Open Reading Frame 118 2
  • TLD Domain-Containing Protein 2 3
  • Hypothetical Protein LOC140711 2
  • TLD Domain Containing 2 2
  • C20orf118 3

External Ids for TLDC2 Gene

Previous HGNC Symbols for TLDC2 Gene

  • C20orf118

Previous GeneCards Identifiers for TLDC2 Gene

  • GC20P035505

Summaries for TLDC2 Gene

GeneCards Summary for TLDC2 Gene

TLDC2 (TBC/LysM-Associated Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is OXR1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC2 Gene

Genomics for TLDC2 Gene

Regulatory Elements for TLDC2 Gene

Enhancers for TLDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F036459 0.6 ENCODE 20.5 -409.4 -409358 13.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 RBM12 AAR2 CPNE1 TGIF2 RBL1 RPL36P4 MYL9 TLDC2 DLGAP4-AS1 MANBAL
GH20F036540 0.5 FANTOM5 ENCODE 12.5 -333.2 -333155 5.3 HDGF SIN3A YY1 ZNF121 GLIS2 GATA2 ELK1 ZNF263 SP3 GLIS1 RBM12 CPNE1 MYL9 RPL36P4 TLDC2 AAR2 TGIF2 RBL1 DLGAP4 GC20P036550
GH20F036988 1.2 FANTOM5 Ensembl ENCODE 9.9 +113.1 113081 2.4 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 AAR2 RBL1 LINC00489 HMGB3P2 MROH8 TGIF2 LOC100419562 DLGAP4-AS1 TLDC2 LOC100287792
GH20F037093 0.2 ENCODE 9.8 +219.3 219335 2.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC AAR2 TGIF2 RPRD1B LINC00489 RBL1 TTI1 MROH8 MYL9 LOC100419562 MANBAL
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TLDC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLDC2 Gene

36,876,121 bp from pter
36,894,235 bp from pter
18,115 bases
Plus strand

Genomic View for TLDC2 Gene

Genes around TLDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLDC2 Gene

Proteins for TLDC2 Gene

  • Protein details for TLDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLD domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KVU8

    Protein attributes for TLDC2 Gene

    215 amino acids
    Molecular mass:
    23912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLDC2 Gene

Post-translational modifications for TLDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLDC2 Gene

No data available for DME Specific Peptides for TLDC2 Gene

Domains & Families for TLDC2 Gene

Protein Domains for TLDC2 Gene


Suggested Antigen Peptide Sequences for TLDC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TLD domain.
  • Belongs to the OXR1 family.
  • Contains 1 TLD domain.
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with TLDC2: view

No data available for Gene Families for TLDC2 Gene

Function for TLDC2 Gene

Phenotypes for TLDC2 Gene

genes like me logo Genes that share phenotypes with TLDC2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TLDC2 Gene

Localization for TLDC2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TLDC2 Gene

Pathways & Interactions for TLDC2 Gene

SuperPathways for TLDC2 Gene

No Data Available

Interacting Proteins for TLDC2 Gene

Gene Ontology (GO) - Biological Process for TLDC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TLDC2 Gene

Transcripts for TLDC2 Gene

mRNA/cDNA for TLDC2 Gene

(5) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLDC2 Gene

TBC/LysM-associated domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC2 Gene

No ASD Table

Relevant External Links for TLDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TLDC2 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC2 Gene

This gene is overexpressed in Colon - Transverse (x15.3), Small Intestine - Terminal Ileum (x13.4), and Kidney - Cortex (x7.0).

NURSA nuclear receptor signaling pathways regulating expression of TLDC2 Gene:


SOURCE GeneReport for Unigene cluster for TLDC2 Gene:

genes like me logo Genes that share expression patterns with TLDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TLDC2 Gene

Orthologs for TLDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TLDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLDC2 34 35
  • 99.69 (n)
(Bos Taurus)
Mammalia TLDC2 34 35
  • 86.05 (n)
(Canis familiaris)
Mammalia TLDC2 34 35
  • 84.81 (n)
(Rattus norvegicus)
Mammalia Tldc2 34
  • 83.02 (n)
(Mus musculus)
Mammalia Tldc2 34 16 35
  • 82.08 (n)
(Ornithorhynchus anatinus)
Mammalia TLDC2 35
  • 75 (a)
(Monodelphis domestica)
Mammalia TLDC2 35
  • 70 (a)
(Gallus gallus)
Aves TLDC2 34 35
  • 66.27 (n)
(Anolis carolinensis)
Reptilia TLDC2 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tldc2 34
  • 57.05 (n)
(Danio rerio)
Actinopterygii TLDC2 35
  • 13 (a)
fruit fly
(Drosophila melanogaster)
Insecta mtd 35
  • 7 (a)
(Caenorhabditis elegans)
Secernentea lmd-3 35
  • 9 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL078W 34
  • 51.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E19449g 34
  • 45.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OXR1 34 37
  • 43.33 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02394 34
  • 44.33 (n)
Species where no ortholog for TLDC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC2 Gene

Gene Tree for TLDC2 (if available)
Gene Tree for TLDC2 (if available)

Paralogs for TLDC2 Gene

Paralogs for TLDC2 Gene

(3) SIMAP similar genes for TLDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TLDC2: view

Variants for TLDC2 Gene

Sequence variations from dbSNP and Humsavar for TLDC2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1024191 -- 36,879,632(+) aggag(A/T)tcaag intron-variant
rs1063121 -- 36,890,397(-) GAAAG(A/G)GAAAG intron-variant, downstream-variant-500B
rs10665649 -- 36,890,419(+) TTTCT(-/TTCTTTAT/TTCTTTATTTCT/TTCTTTC/TTCTTTCTTTCT)TTTCT intron-variant, downstream-variant-500B
rs10665651 -- 36,890,463(+) tcCtt(C/T)ctttc intron-variant, downstream-variant-500B
rs11086818 -- 36,882,536(+) AAAAA(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLDC2 Gene

Variant ID Type Subtype PubMed ID
esv3645741 CNV gain 21293372
nsv1057845 CNV gain 25217958
nsv585944 CNV loss 21841781

Variation tolerance for TLDC2 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.69; 57.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLDC2 Gene

Disorders for TLDC2 Gene

Relevant External Links for TLDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TLDC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC2 Gene

Publications for TLDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TLDC2 Gene

Sources for TLDC2 Gene

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