TLDC1 Gene
protein-coding GIFtS: 39
GCID: GC16M084510
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TBC/LysM-Associated Domain Containing 1(Previous name: KIAA1609)
(Previous symbol: KIAA1609)
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Aliases
for TLDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| TBC/LysM-Associated Domain Containing 11 2 | | KIAA16091 2 3 | | TLD Domain Containing 11 2 | | TBC/LysM-Associated Domain-Containing Protein 12 3 | | TLD Domain-Containing Protein 12 |
Export aliases for TLDC1 gene to outside databases |
Summaries
for TLDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for TLDC1 Gene: 
TLDC1 (TBC/LysM-associated domain containing 1) is a protein-coding gene. An important paralog of this gene is OXR1.
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Genomic Views
for TLDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NT_010498.15 NC_018927.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TLDC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TLDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q24.1 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24.1TLDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M084510: view genomic region
(about GC identifiers)
Start:
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84,509,966 bp from pter |
End:
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84,587,639 bp from pter |
Size:
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77,674 bases |
Orientation:
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minus strand |
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Proteins
for TLDC1 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
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UniProtKB/Swiss-Prot: TLDC1_HUMAN, Q6P9B6 (See
protein sequence)Recommended Name: TLD domain-containing protein 1 Size: 456 amino acids; 50994 Da
Sequence caution: Sequence=BAB13435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8IZ64 Q9HCG3 Q9NTE8Explore the universe of human proteins at neXtProt for TLDC1: NX_Q6P9B6
Explore proteomics data for TLDC1 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q6P9B6
TLDC1 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_065998.3
ENSEMBL proteins: ENSP00000343635 ENSP00000454265 ENSP00000455332 ENSP00000457557 ENSP00000457115 ENSP00000455557 ENSP00000441997
Human Recombinant Protein Products for TLDC1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TLDC1 for ontologies About GeneDecksing
TLDC1 Antibody Products:
Assay Products for TLDC1: |
Protein
Domains /
Families
for TLDC1 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q6P9B6 ProtoNet protein and cluster: Q6P9B6 UniProtKB/Swiss-Prot: TLDC1_HUMAN, Q6P9B6Similarity: Contains 1 TLD domain
TLDC1 for domains About GeneDecksing
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Function
for TLDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TLDC1 for ontologies About GeneDecksing
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TLDC1 | |  | Search LifeMap BioReagents cell lines for TLDC1 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLDC1 |
Pathways & Interactions
for TLDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLDC1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/9 Interacting proteins for TLDC1 (Q6P9B61, 3 ENSP000003436354) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
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Drugs & Compounds
for TLDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TLDC1
Search CenterWatch for drugs/clinical trials and news about TLDC1
|
Transcripts
for TLDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TLDC1 gene: NM_020947.3 Unigene Cluster for TLDC1: TBC/LysM-associated domain containing 1 Hs.288274 [show with all ESTs]Unigene Representative Sequence: NM_02094710 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000343629(uc002fib.3 uc010vod.2) ENST00000566995 ENST00000570036
ENST00000567321 ENST00000561807 ENST00000565079 ENST00000562447 ENST00000565701
ENST00000565765 ENST00000535580
Additional mRNA sequence: AK291237.1 AK297241.1 AK310887.1 AL137316.1 BC023251.1 BC060844.1 13 DOTS entries: DT.452459 DT.91912634 DT.100817790 DT.120708617 DT.206241 DT.100817788 DT.100817791 DT.95354751 DT.100835140 DT.91675769 DT.120708663 DT.100802090 DT.97781874 24/110 AceView cDNA sequences (see all 110): CR614446 AA636129 AW117603 AA864757 BF222108 AA195017 N99979 CA392378 BQ009692 AA604558 AI499212 CN479317 BM671809 BQ435017 BX403527 BI767086 BC023251 BC060844 AA195124 AA923026 BU856861 AA973791 BG249176 AA035541
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TLDC1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ |
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| SP1: | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11 |
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| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for TLDC1
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Expression
for TLDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TLDC1 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
About this image
See TLDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TLDC1
SOURCE GeneReport for Unigene cluster: Hs.288274
SABiosciences Custom PCR Arrays for TLDC1
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for TLDC1
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TLDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLDC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLDC1 |
Orthologs
for TLDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TLDC1 gene from 9/16 species (see all 16) About this table
ENSEMBL Gene Tree for TLDC1 (if available)
TreeFam Gene Tree for TLDC1 (if available) |
Paralogs
for TLDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TLDC1 gene
- OXR12 NCOA72 TLDC22
3 SIMAP similar genes for TLDC1 using alignment to 7 protein entries: TLDC1_HUMAN (see all proteins):KIAA1609 OXR1 C20orf118
TLDC1 for paralogs About GeneDecksing
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Genomic Variants
for TLDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TLDC1 (84509966 - 84587639 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for TLDC1: --
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing TLDC1 |
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Disorders
/ Diseases
for TLDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TLDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TLDC1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with TLDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system. (PubMed id 20213681)2 Suzuki T.... Utsumi T. (2010)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1 Schroeder B.... Hasilik A. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
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External Searches for TLDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TLDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TLDC1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TLDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TLDC1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TLDC1 gene:
Search GeneIP for patents involving TLDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TLDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TLDC1 | | | QIAGEN SeqTarget long-range PCR primers for resequencing TLDC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TLDC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TLDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TLDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TLDC1 |
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 |  |  |  | |
| | | | Search Tocris compounds for TLDC1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TLDC1 |
|  |  |  |  | | | | ThermoFisher Antibodies for TLDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TLDC1 |
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GeneCards Homepage -
Last full update: 23 Oct 2013 -
Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014
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