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Aliases for TLDC1 Gene

Aliases for TLDC1 Gene

  • TBC/LysM-Associated Domain Containing 1 2 3
  • KIAA1609 2 3 4
  • TBC/LysM-Associated Domain-Containing Protein 1 3 4
  • TLD Domain Containing 1 2 3
  • TLD Domain-Containing Protein 1 3

External Ids for TLDC1 Gene

Previous Symbols for TLDC1 Gene

  • KIAA1609

Summaries for TLDC1 Gene

GeneCards Summary for TLDC1 Gene

TLDC1 (TBC/LysM-Associated Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TLDC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC1 Gene

Genomics for TLDC1 Gene

Genomic Location for TLDC1 Gene

Start:
84,476,360 bp from pter
End:
84,554,033 bp from pter
Size:
77,674 bases
Orientation:
Minus strand

Genomic View for TLDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLDC1 Gene

No data available for Regulatory Elements for TLDC1 Gene

Proteins for TLDC1 Gene

  • Protein details for TLDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9B6-TLDC1_HUMAN
    Recommended name:
    TLD domain-containing protein 1
    Protein Accession:
    Q6P9B6
    Secondary Accessions:
    • Q8IZ64
    • Q9HCG3
    • Q9NTE8

    Protein attributes for TLDC1 Gene

    Size:
    456 amino acids
    Molecular mass:
    50994 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TLDC1 Gene

Proteomics data for TLDC1 Gene at MOPED

Post-translational modifications for TLDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLDC1 Gene

No data available for DME Specific Peptides for TLDC1 Gene

Domains for TLDC1 Gene

Protein Domains for TLDC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TLDC1_HUMAN
Domain:
  • Contains 1 TLD domain.:
    • Q6P9B6
genes like me logo Genes that share domains with TLDC1: view

No data available for Gene Families for TLDC1 Gene

Function for TLDC1 Gene

Gene Ontology (GO) - Molecular Function for TLDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TLDC1: view

miRNA for TLDC1 Gene

miRTarBase miRNAs that target TLDC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TLDC1 Gene

Localization for TLDC1 Gene

Gene Ontology (GO) - Cellular Components for TLDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with TLDC1: view

Pathways for TLDC1 Gene

SuperPathways for TLDC1 Gene

No Data Available

Interacting Proteins for TLDC1 Gene

Gene Ontology (GO) - Biological Process for TLDC1 Gene

None

No data available for Pathways by source for TLDC1 Gene

Transcripts for TLDC1 Gene

Unigene Clusters for TLDC1 Gene

TBC/LysM-associated domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4: - - -
SP5: - - - -
SP6: - - -
SP7:
SP8: -
SP9: - -
SP10:

ExUns: 11
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TLDC1 Gene

GeneLoc Exon Structure for
TLDC1
ECgene alternative splicing isoforms for
TLDC1

Expression for TLDC1 Gene

mRNA expression in normal human tissues for TLDC1 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLDC1 Gene

SOURCE GeneReport for Unigene cluster for TLDC1 Gene Hs.288274

genes like me logo Genes that share expressions with TLDC1: view

Orthologs for TLDC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TLDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLDC1 36
  • 98.9 (n)
  • 98.25 (a)
TLDC1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLDC1 36
  • 79.05 (n)
  • 72.75 (a)
TLDC1 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLDC1 36
  • 81.61 (n)
  • 78.02 (a)
TLDC1 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4632415K11Rik 16
Tldc1 36
  • 73.42 (n)
  • 65.64 (a)
Tldc1 37
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLDC1 37
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLDC1 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tldc1 36
  • 74.86 (n)
  • 66.51 (a)
chicken
(Gallus gallus)
Aves KIAA1609 36
  • 64.69 (n)
  • 60.66 (a)
KIAA1609 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLDC1 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tldc1 36
  • 57.76 (n)
  • 50.55 (a)
zebrafish
(Danio rerio)
Actinopterygii tldc1 36
  • 54.98 (n)
  • 44.94 (a)
tldc1 37
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5149 37
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eak-7 37
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06260 36
  • 41.98 (n)
  • 29.88 (a)
rice
(Oryza sativa)
Liliopsida Os12g0157200 36
  • 48.77 (n)
  • 35.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToOne
Species with no ortholog for TLDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC1 Gene

ENSEMBL:
Gene Tree for TLDC1 (if available)
TreeFam:
Gene Tree for TLDC1 (if available)

Paralogs for TLDC1 Gene

Paralogs for TLDC1 Gene

Selected SIMAP similar genes for TLDC1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TLDC1: view

Variants for TLDC1 Gene

Sequence variations from dbSNP and Humsavar for TLDC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10086 -- 84,476,649(-) ACTGC(A/G)TGATG utr-variant-3-prime
rs368681 -- 84,500,646(+) CATCT(C/G)ATCTC intron-variant
rs370383 -- 84,500,983(+) CCAGC(G/T)ACTTG intron-variant
rs370527 -- 84,501,155(+) GGGGA(C/T)GGGTG intron-variant
rs373869 -- 84,489,986(+) AGTAG(A/G)TGAAT intron-variant

Relevant External Links for TLDC1 Gene

HapMap Linkage Disequilibrium report
TLDC1
Human Gene Mutation Database (HGMD)
TLDC1

No data available for Structural Variations from Database of Genomic Variants (DGV) for TLDC1 Gene

Disorders for TLDC1 Gene

No disorders were found for TLDC1 Gene.

No data available for UniProtKB/Swiss-Prot for TLDC1 Gene

Publications for TLDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for TLDC1 Gene

Sources for TLDC1 Gene

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