Aliases for TLDC1 Gene
Aliases for TLDC1 Gene
External Ids for TLDC1 Gene
- HGNC: 29325
- Entrez Gene: 57707
- Ensembl: ENSG00000140950
- UniProtKB: Q6P9B6
Previous HGNC Symbols for TLDC1 Gene
- KIAA1609
Summaries for TLDC1 Gene
GeneCards Summary for TLDC1 Gene
TLDC1 (TBC/LysM-Associated Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is OXR1.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC1 Gene
Genomics for TLDC1 Gene
GeneHancer (GH) Regulatory Elements for TLDC1 Gene
Promoters and enhancers for TLDC1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH16I084498 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 572 | +51.1 | 51102 | 8.4 | HDGF PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B SLC30A9 | TLDC1 ENSG00000260300 KLHL36 ATP2C2-AS1 HSBP1 ENSG00000261243 | |
| GH16I084553 | Enhancer | 0.6 | Ensembl ENCODE | 550.8 | +0.2 | 158 | 1.5 | ZBTB33 NR2F2 | TLDC1 COTL1 ENSG00000261243 | |
| GH16I084555 | Enhancer | 0.6 | ENCODE | 550.8 | -1.9 | -1926 | 1.2 | MEIS2 ZNF263 MXI1 RFX1 HLF CEBPB MAFG BMI1 SP1 POLR2A | TLDC1 GC16P084565 | |
| GH16I084552 | Enhancer | 0.2 | Ensembl | 550.8 | +1.7 | 1744 | 0.6 | TLDC1 ENSG00000261243 | ||
| GH16I085518 | Enhancer | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 18.8 | -968.6 | -968618 | 8.2 | CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF548 NFYC SSRP1 | ENSG00000270184 KLHL36 RNU1-103P RN7SL381P ZDHHC7 CRISPLD2 GSE1 TLDC1 ENSG00000260859 EMC8 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TLDC1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TLDC1 Gene
Genomic Locations for TLDC1 Gene
- chr16:84,476,360-84,554,045
- (GRCh38/hg38)
- Size:
- 77,686 bases
- Orientation:
- Minus strand
- chr16:84,509,966-84,587,639
- (GRCh37/hg19)
Genomic View for TLDC1 Gene
Genes around TLDC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q24.1 by Ensembl
- 16q24.1 by Entrez Gene
- 16q24.1 by HGNC
TLDC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TLDC1 Gene
Proteins for TLDC1 Gene
-
Protein details for TLDC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6P9B6-TLDC1_HUMAN
- Recommended name:
- TLD domain-containing protein 1
- Protein Accession:
- Q6P9B6
- Q8IZ64
- Q9HCG3
- Q9NTE8
Protein attributes for TLDC1 Gene
- Size:
- 456 amino acids
- Molecular mass:
- 50994 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB13435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for TLDC1 Gene
Post-translational modifications for TLDC1 Gene
No Post-translational modifications
Other Protein References for TLDC1 Gene
Antibody Products
- Novus Biologicals Antibodies for TLDC1
- Invitrogen Antibodies for TLDC1
- Search GeneTex for Antibodies for TLDC1
Protein Products
-
OriGene Purified Proteins for TLDC1
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- Search GeneTex for Proteins for TLDC1
-
Abcam proteins for TLDC1
Assay Products
No data available for DME Specific Peptides for TLDC1 Gene
Domains & Families for TLDC1 Gene
Gene Families for TLDC1 Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for TLDC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TLDC1 Gene
Function for TLDC1 Gene
Phenotypes From GWAS Catalog for TLDC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for TLDC1 Gene
- GenomeRNAi human phenotypes for TLDC1:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for TLDC1 gene
-
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- Search ViGene Biosciences for TLDC1
CRISPR Products
-
OriGene CRISPR knockouts for TLDC1
- genomics-online: gRNA clones - Search results for available TLDC1 gene related products
- Applied Biological Materials CRISPR for TLDC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLDC1
- GenScript: Design CRISPR guide RNA sequences for TLDC1
miRNA for TLDC1 Gene
- miRTarBase miRNAs that target TLDC1
-
- hsa-mir-98-5p (MIRT027496)
- hsa-mir-30a-5p (MIRT028438)
- hsa-mir-6807-5p (MIRT517048)
- hsa-mir-7151-3p (MIRT517049)
- hsa-mir-6884-3p (MIRT517050)
- hsa-mir-5095 (MIRT517051)
- hsa-mir-6849-3p (MIRT517052)
- hsa-mir-500b-3p (MIRT517053)
- hsa-mir-1228-3p (MIRT517054)
- hsa-mir-6504-3p (MIRT517055)
- hsa-mir-4438 (MIRT517056)
- hsa-mir-874-5p (MIRT529554)
- hsa-mir-499b-5p (MIRT529555)
- hsa-mir-5583-3p (MIRT529556)
- hsa-mir-670-3p (MIRT646825)
- hsa-mir-4713-5p (MIRT646826)
- hsa-mir-664b-3p (MIRT646827)
- hsa-mir-579-3p (MIRT646828)
- hsa-mir-5696 (MIRT646829)
- hsa-mir-377-3p (MIRT646830)
- hsa-mir-4326 (MIRT646831)
- hsa-mir-26b-3p (MIRT646832)
- hsa-mir-2116-3p (MIRT646833)
- hsa-mir-532-3p (MIRT646834)
- hsa-mir-150-5p (MIRT646835)
- hsa-mir-342-3p (MIRT646836)
- hsa-mir-4729 (MIRT646837)
- hsa-mir-664a-3p (MIRT646838)
- hsa-mir-4524b-3p (MIRT646839)
- hsa-mir-4262 (MIRT646840)
- hsa-mir-181d-5p (MIRT646841)
- hsa-mir-181c-5p (MIRT646842)
- hsa-mir-181b-5p (MIRT646843)
- hsa-mir-181a-5p (MIRT646844)
- hsa-mir-8485 (MIRT646845)
miRNA Products
- Search ViGene Biosciences for TLDC1
Inhibitory RNA Products
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Clone Products
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TLDC1
-
ViGene Biosciences adenoviral particle packaged cDNA for TLDC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TLDC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TLDC1 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLDC1 Gene
Localization for TLDC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TLDC1 Gene
- Membrane. Cytoplasm.
| Compartment | Confidence |
|---|---|
| lysosome | 5 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Nucleoli (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 24223779 |
| GO:0005765 | lysosomal membrane | HDA,IDA | 17897319 |
| GO:0016020 | membrane | IDA,IEA | 24223779 |
Pathways & Interactions for TLDC1 Gene
No Data Available
Interacting Proteins for TLDC1 Gene
Selected Interacting proteins:
Q6P9B6-TLDC1_HUMAN
ENSP00000343635
for TLDC1 Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903204 | negative regulation of oxidative stress-induced neuron death | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for TLDC1 Gene
Transcripts for TLDC1 Gene
mRNA/cDNA for TLDC1 Gene
- (9) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (110) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TLDC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TLDC1
- genomics-online: gRNA clones - Search results for available TLDC1 gene related products
- Applied Biological Materials CRISPR for TLDC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TLDC1
- GenScript: Design CRISPR guide RNA sequences for TLDC1
miRNA Products
- Search ViGene Biosciences for TLDC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TLDC1
- Browse OriGene Inhibitory RNA Products For TLDC1
- genomics-online: shRNA clones - Search results for available TLDC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TLDC1 gene
Clone Products
- Sino Biological Human cDNA Clone for TLDC1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available TLDC1 gene related products
- orf clones - Search results for available TLDC1 gene related products
- Applied Biological Materials Clones for TLDC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: |
| ExUns: | 11 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: |
Expression for TLDC1 Gene
mRNA differential expression in normal tissues according to GTEx for TLDC1 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.1).
This gene is overexpressed in Peripheral blood mononuclear cells (8.9) and Breast (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TLDC1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TLDC1 Gene:
TLDC1SOURCE GeneReport for Unigene cluster for TLDC1 Gene:
Hs.288274Evidence on tissue expression from TISSUES for TLDC1 Gene
- Nervous system(4.5)
- Kidney(4.1)
Primer Products
-
OriGene qPCR primer pairs for TLDC1
- genomics-online: primer clones - Search results for available TLDC1 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLDC1 Gene
Orthologs for TLDC1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TLDC1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TLDC1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TLDC1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tldc1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tldc1 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TLDC1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TLDC1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | KIAA1609 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TLDC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tldc1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tldc1 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5149 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | eak-7 34 |
|
OneToOne | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G06260 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os12g0157200 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for TLDC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TLDC1 Gene
(3) SIMAP similar genes for TLDC1 Gene using alignment to 7 proteins:
Variants for TLDC1 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000054319 | -- | 84,503,292(-) | G/A | intron_variant | |
| rs1000130190 | -- | 84,497,657(-) | A/C | intron_variant | |
| rs1000185260 | -- | 84,506,222(-) | T/C | upstream_transcript_variant | |
| rs1000239932 | -- | 84,482,439(-) | A/C | intron_variant | |
| rs1000273711 | -- | 84,484,117(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv169n21 | CNV | loss | 19592680 |
| dgv3057n100 | CNV | loss | 25217958 |
| dgv5262n54 | CNV | loss | 21841781 |
| dgv549e214 | CNV | gain | 21293372 |
| esv2714828 | CNV | deletion | 23290073 |
| esv2714830 | CNV | deletion | 23290073 |
| esv2714831 | CNV | deletion | 23290073 |
| esv3303917 | CNV | mobile element insertion | 20981092 |
| esv3389512 | CNV | insertion | 20981092 |
| esv3639429 | CNV | gain | 21293372 |
| esv3892928 | CNV | loss | 25118596 |
| esv3892929 | CNV | loss | 25118596 |
| nsv1058049 | CNV | loss | 25217958 |
| nsv1059640 | CNV | loss | 25217958 |
| nsv1061004 | CNV | loss | 25217958 |
| nsv1064308 | CNV | loss | 25217958 |
| nsv1065249 | CNV | gain | 25217958 |
| nsv457600 | CNV | loss | 19166990 |
| nsv483044 | CNV | gain | 15286789 |
| nsv573425 | CNV | loss | 21841781 |
| nsv573430 | CNV | loss | 21841781 |
| nsv573454 | CNV | loss | 21841781 |
| nsv833311 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.12;
69.22% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TLDC1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLDC1 Gene
Disorders for TLDC1 Gene
Additional Disease Information for TLDC1
No disorders were found for TLDC1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC1 Gene
Publications for TLDC1 Gene
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark, an integral membrane protein of the endoplasmic reticulum. (PMID: 24223779) Moriya K … Utsumi T (PloS one 2013) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
- Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner BA … Cristea IM (Molecular & cellular proteomics : MCP 2015) 3 58
Products for TLDC1 Gene
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- genomics-online: cdna clones - Search results for available KIAA1609 gene related products
- orf clones - Search results for available KIAA1609 gene related products
- genomics-online: gRNA clones - Search results for available KIAA1609 gene related products
- genomics-online: primer clones - Search results for available KIAA1609 gene related products
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Sources for TLDC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
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