Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TLDC1 Gene

Aliases for TLDC1 Gene

  • TBC/LysM-Associated Domain Containing 1 2 3
  • KIAA1609 2 3 4
  • TBC/LysM-Associated Domain-Containing Protein 1 3 4
  • TLD Domain Containing 1 2 3
  • TLD Domain-Containing Protein 1 3

External Ids for TLDC1 Gene

Previous HGNC Symbols for TLDC1 Gene

  • KIAA1609

Summaries for TLDC1 Gene

GeneCards Summary for TLDC1 Gene

TLDC1 (TBC/LysM-Associated Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TLDC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC1 Gene

Genomics for TLDC1 Gene

Genomic Location for TLDC1 Gene

84,476,360 bp from pter
84,554,033 bp from pter
77,674 bases
Minus strand

Genomic View for TLDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLDC1 Gene

No data available for Regulatory Elements for TLDC1 Gene

Proteins for TLDC1 Gene

  • Protein details for TLDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLD domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IZ64
    • Q9HCG3
    • Q9NTE8

    Protein attributes for TLDC1 Gene

    456 amino acids
    Molecular mass:
    50994 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB13435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TLDC1 Gene

Proteomics data for TLDC1 Gene at MOPED

Post-translational modifications for TLDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLDC1 Gene

No data available for DME Specific Peptides for TLDC1 Gene

Domains for TLDC1 Gene

Protein Domains for TLDC1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q6P9B6
  • Contains 1 TLD domain.
genes like me logo Genes that share domains with TLDC1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TLDC1 Gene

Function for TLDC1 Gene

Gene Ontology (GO) - Molecular Function for TLDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TLDC1: view

Animal Model Products

CRISPR Products

miRNA for TLDC1 Gene

miRTarBase miRNAs that target TLDC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TLDC1 Gene

Localization for TLDC1 Gene

Gene Ontology (GO) - Cellular Components for TLDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
genes like me logo Genes that share ontologies with TLDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TLDC1 Gene

Pathways for TLDC1 Gene

SuperPathways for TLDC1 Gene

No Data Available

Interacting Proteins for TLDC1 Gene

Gene Ontology (GO) - Biological Process for TLDC1 Gene


No data available for Pathways by source for TLDC1 Gene

Transcripts for TLDC1 Gene

Unigene Clusters for TLDC1 Gene

TBC/LysM-associated domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLDC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TLDC1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - -
SP2: - - - -
SP4: - - -
SP5: - - - -
SP6: - - -
SP8: -
SP9: - -

ExUns: 11

Relevant External Links for TLDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLDC1 Gene

mRNA expression in normal human tissues for TLDC1 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLDC1 Gene

SOURCE GeneReport for Unigene cluster for TLDC1 Gene Hs.288274

genes like me logo Genes that share expressions with TLDC1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TLDC1 Gene

Orthologs for TLDC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TLDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLDC1 35
  • 98.9 (n)
  • 98.25 (a)
TLDC1 36
  • 98 (a)
(Bos Taurus)
Mammalia TLDC1 35
  • 79.05 (n)
  • 72.75 (a)
TLDC1 36
  • 73 (a)
(Canis familiaris)
Mammalia TLDC1 35
  • 81.61 (n)
  • 78.02 (a)
TLDC1 36
  • 78 (a)
(Mus musculus)
Mammalia 4632415K11Rik 16
Tldc1 35
  • 73.42 (n)
  • 65.64 (a)
Tldc1 36
  • 65 (a)
(Monodelphis domestica)
Mammalia TLDC1 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia TLDC1 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Tldc1 35
  • 74.86 (n)
  • 66.51 (a)
(Gallus gallus)
Aves KIAA1609 35
  • 64.69 (n)
  • 60.66 (a)
KIAA1609 36
  • 59 (a)
(Anolis carolinensis)
Reptilia TLDC1 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tldc1 35
  • 57.76 (n)
  • 50.55 (a)
(Danio rerio)
Actinopterygii tldc1 35
  • 54.98 (n)
  • 44.94 (a)
tldc1 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5149 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea eak-7 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06260 35
  • 41.98 (n)
  • 29.88 (a)
(Oryza sativa)
Liliopsida Os12g0157200 35
  • 48.77 (n)
  • 35.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for TLDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC1 Gene

Gene Tree for TLDC1 (if available)
Gene Tree for TLDC1 (if available)

Paralogs for TLDC1 Gene

Paralogs for TLDC1 Gene

Selected SIMAP similar genes for TLDC1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TLDC1: view

Variants for TLDC1 Gene

Sequence variations from dbSNP and Humsavar for TLDC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10086 -- 84,476,649(-) ACTGC(A/G)TGATG utr-variant-3-prime
rs368681 -- 84,500,646(+) CATCT(C/G)ATCTC intron-variant
rs370383 -- 84,500,983(+) CCAGC(G/T)ACTTG intron-variant
rs370527 -- 84,501,155(+) GGGGA(C/T)GGGTG intron-variant
rs373869 -- 84,489,986(+) AGTAG(A/G)TGAAT intron-variant

Relevant External Links for TLDC1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLDC1 Gene

Disorders for TLDC1 Gene

No disorders were found for TLDC1 Gene.

No data available for UniProtKB/Swiss-Prot for TLDC1 Gene

Publications for TLDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3

Products for TLDC1 Gene

Sources for TLDC1 Gene

Back to Top