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Aliases for TLDC1 Gene

Aliases for TLDC1 Gene

  • TBC/LysM-Associated Domain Containing 1 2 3 5
  • KIAA1609 2 3 4
  • TBC/LysM-Associated Domain-Containing Protein 1 3 4
  • TLD Domain Containing 1 2 3

External Ids for TLDC1 Gene

Previous HGNC Symbols for TLDC1 Gene

  • KIAA1609

Summaries for TLDC1 Gene

GeneCards Summary for TLDC1 Gene

TLDC1 (TBC/LysM-Associated Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is NCOA7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLDC1 Gene

Genomics for TLDC1 Gene

Regulatory Elements for TLDC1 Gene

Enhancers for TLDC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TLDC1 on UCSC Golden Path with GeneCards custom track

Promoters for TLDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TLDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TLDC1 Gene

Chromosome:
16
Start:
84,476,360 bp from pter
End:
84,554,045 bp from pter
Size:
77,686 bases
Orientation:
Minus strand

Genomic View for TLDC1 Gene

Genes around TLDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLDC1 Gene

Proteins for TLDC1 Gene

  • Protein details for TLDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P9B6-TLDC1_HUMAN
    Recommended name:
    TLD domain-containing protein 1
    Protein Accession:
    Q6P9B6
    Secondary Accessions:
    • Q8IZ64
    • Q9HCG3
    • Q9NTE8

    Protein attributes for TLDC1 Gene

    Size:
    456 amino acids
    Molecular mass:
    50994 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB13435.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TLDC1 Gene

Proteomics data for TLDC1 Gene at MOPED

Post-translational modifications for TLDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLDC1 Gene

No data available for DME Specific Peptides for TLDC1 Gene

Domains & Families for TLDC1 Gene

Protein Domains for TLDC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TLDC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P9B6

UniProtKB/Swiss-Prot:

TLDC1_HUMAN :
  • Contains 1 TLD domain.
Domain:
  • Contains 1 TLD domain.
genes like me logo Genes that share domains with TLDC1: view

No data available for Gene Families for TLDC1 Gene

Function for TLDC1 Gene

Phenotypes for TLDC1 Gene

GenomeRNAi human phenotypes for TLDC1:
genes like me logo Genes that share phenotypes with TLDC1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLDC1 Gene

Localization for TLDC1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TLDC1 Gene

Pathways & Interactions for TLDC1 Gene

SuperPathways for TLDC1 Gene

No Data Available

Interacting Proteins for TLDC1 Gene

Gene Ontology (GO) - Biological Process for TLDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TLDC1 Gene

Drugs & Compounds for TLDC1 Gene

No Compound Related Data Available

Transcripts for TLDC1 Gene

Unigene Clusters for TLDC1 Gene

TBC/LysM-associated domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLDC1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - -
SP2: - - - -
SP3:
SP4: - - -
SP5: - - - -
SP6: - - -
SP7:
SP8: -
SP9: - -
SP10:

ExUns: 11
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TLDC1 Gene

GeneLoc Exon Structure for
TLDC1
ECgene alternative splicing isoforms for
TLDC1

Expression for TLDC1 Gene

mRNA expression in normal human tissues for TLDC1 Gene

mRNA differential expression in normal tissues according to GTEx for TLDC1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for TLDC1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.9) and Breast (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TLDC1 Gene



SOURCE GeneReport for Unigene cluster for TLDC1 Gene Hs.288274

genes like me logo Genes that share expression patterns with TLDC1: view

Protein tissue co-expression partners for TLDC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TLDC1 Gene

Orthologs for TLDC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TLDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TLDC1 35
  • 79.05 (n)
  • 72.75 (a)
TLDC1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLDC1 35
  • 81.61 (n)
  • 78.02 (a)
TLDC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tldc1 35
  • 73.42 (n)
  • 65.64 (a)
Tldc1 16
Tldc1 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TLDC1 35
  • 98.9 (n)
  • 98.25 (a)
TLDC1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tldc1 35
  • 74.86 (n)
  • 66.51 (a)
oppossum
(Monodelphis domestica)
Mammalia TLDC1 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLDC1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1609 35
  • 64.69 (n)
  • 60.66 (a)
KIAA1609 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLDC1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tldc1 35
  • 57.76 (n)
  • 50.55 (a)
zebrafish
(Danio rerio)
Actinopterygii tldc1 35
  • 54.98 (n)
  • 44.94 (a)
tldc1 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5149 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eak-7 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06260 35
  • 41.98 (n)
  • 29.88 (a)
rice
(Oryza sativa)
Liliopsida Os12g0157200 35
  • 48.77 (n)
  • 35.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for TLDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLDC1 Gene

ENSEMBL:
Gene Tree for TLDC1 (if available)
TreeFam:
Gene Tree for TLDC1 (if available)

Paralogs for TLDC1 Gene

Paralogs for TLDC1 Gene

(3) SIMAP similar genes for TLDC1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TLDC1: view

Variants for TLDC1 Gene

Sequence variations from dbSNP and Humsavar for TLDC1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8046813 - 84,498,058(+) AGCTC(A/C/T)GCCCC reference, missense
rs8055536 - 84,495,776(+) AACAG(C/G)TGGGA reference, missense
rs436278 - 84,489,291(+) TTCAT(C/G)TCAGA reference, missense
rs431818 - 84,486,931(+) CAGGA(C/T)GAGAA reference, missense
rs34244563 - 84,486,890(-) CCTGA(C/G)CGTCA reference, missense

Variation tolerance for TLDC1 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLDC1 Gene

Human Gene Mutation Database (HGMD)
TLDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TLDC1 Gene

Disorders for TLDC1 Gene

Relevant External Links for TLDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TLDC1

No disorders were found for TLDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLDC1 Gene

Publications for TLDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for TLDC1 Gene

Sources for TLDC1 Gene

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