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Aliases for TLCD2 Gene

Aliases for TLCD2 Gene

  • TLC Domain Containing 2 2 3

External Ids for TLCD2 Gene

Summaries for TLCD2 Gene

GeneCards Summary for TLCD2 Gene

TLCD2 (TLC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is TLCD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLCD2 Gene

Genomics for TLCD2 Gene

Genomic Location for TLCD2 Gene

Start:
1,702,790 bp from pter
End:
1,710,438 bp from pter
Size:
7,649 bases
Orientation:
Minus strand

Genomic View for TLCD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLCD2 Gene

Regulatory Elements for TLCD2 Gene

Proteins for TLCD2 Gene

  • Protein details for TLCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGC4-TLCD2_HUMAN
    Recommended name:
    TLC domain-containing protein 2
    Protein Accession:
    A6NGC4
    Secondary Accessions:

    Protein attributes for TLCD2 Gene

    Size:
    264 amino acids
    Molecular mass:
    28733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLCD2 Gene

Proteomics data for TLCD2 Gene at MOPED

Post-translational modifications for TLCD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLCD2 Gene

Domains for TLCD2 Gene

Protein Domains for TLCD2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TLCD2_HUMAN
Domain:
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.:
    • A6NGC4
Family:
  • Belongs to the TLCD family.:
    • A6NGC4
genes like me logo Genes that share domains with TLCD2: view

No data available for Gene Families for TLCD2 Gene

Function for TLCD2 Gene

Phenotypes for TLCD2 Gene

GenomeRNAi human phenotypes for TLCD2:
genes like me logo Genes that share phenotypes with TLCD2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TLCD2 Gene

Localization for TLCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLCD2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TLCD2 Gene COMPARTMENTS Subcellular localization image for TLCD2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TLCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLCD2: view

Pathways for TLCD2 Gene

SuperPathways for TLCD2 Gene

No Data Available

Interacting Proteins for TLCD2 Gene

Gene Ontology (GO) - Biological Process for TLCD2 Gene

None

No data available for Pathways by source for TLCD2 Gene

Transcripts for TLCD2 Gene

mRNA/cDNA for TLCD2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLCD2 Gene

TLC domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TLCD2 Gene

No ASD Table

Relevant External Links for TLCD2 Gene

GeneLoc Exon Structure for
TLCD2
ECgene alternative splicing isoforms for
TLCD2

Expression for TLCD2 Gene

mRNA expression in normal human tissues for TLCD2 Gene

mRNA differential expression in normal tissues according to GTEx for TLCD2 Gene

This gene is overexpressed in Colon - Transverse (4.3).

SOURCE GeneReport for Unigene cluster for TLCD2 Gene Hs.531005

genes like me logo Genes that share expressions with TLCD2: view

Orthologs for TLCD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLCD2 36
  • 98.83 (n)
  • 98.05 (a)
TLCD2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLCD2 36
  • 82.58 (n)
  • 78.03 (a)
TLCD2 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TLCD2 36
  • 82.7 (n)
  • 77.65 (a)
TLCD2 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tlcd2 36
  • 77.47 (n)
  • 74.22 (a)
Tlcd2 16
Tlcd2 37
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLCD2 37
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlcd2 36
  • 78.38 (n)
  • 74.13 (a)
chicken
(Gallus gallus)
Aves TLCD2 37
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLCD2 37
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tlcd2 37
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K12H6.6 37
  • 18 (a)
ManyToMany
Y48G8AL.13 37
  • 22 (a)
ManyToMany
Y63D3A.8 37
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for TLCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLCD2 Gene

ENSEMBL:
Gene Tree for TLCD2 (if available)
TreeFam:
Gene Tree for TLCD2 (if available)

Paralogs for TLCD2 Gene

Paralogs for TLCD2 Gene

Selected SIMAP similar genes for TLCD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TLCD2: view

Variants for TLCD2 Gene

Sequence variations from dbSNP and Humsavar for TLCD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3208963 -- 1,702,965(-) GTCCT(A/C)AAGAC utr-variant-3-prime
rs3208964 -- 1,702,948(-) CATGT(C/T)TACCA utr-variant-3-prime
rs3208965 -- 1,702,918(-) CTTTG(C/T)CCTCC utr-variant-3-prime
rs4790806 -- 1,706,493(+) GGGTA(C/T)GGTGG utr-variant-3-prime
rs4790807 -- 1,706,494(+) GGTAC(A/G)GTGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TLCD2 Gene

Variant ID Type Subtype PubMed ID
nsv907502 CNV Loss 21882294
nsv907511 CNV Loss 21882294
nsv907515 CNV Loss 21882294
nsv907517 CNV Loss 21882294
nsv827856 CNV Gain 20364138
nsv9490 CNV Loss 18304495
nsv470568 CNV Loss 18288195
nsv516886 CNV Loss 19592680
dgv3033n71 CNV Loss 21882294

Relevant External Links for TLCD2 Gene

HapMap Linkage Disequilibrium report
TLCD2

Disorders for TLCD2 Gene

No disorders were found for TLCD2 Gene.

No data available for UniProtKB/Swiss-Prot for TLCD2 Gene

Publications for TLCD2 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  2. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. (PMID: 16793762) Pewzner-Jung Y. … Futerman A.H. (J. Biol. Chem. 2006) 2 3

Products for TLCD2 Gene

Sources for TLCD2 Gene

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