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Aliases for TLCD2 Gene

Aliases for TLCD2 Gene

  • TLC Domain Containing 2 2 3 5

External Ids for TLCD2 Gene

Previous GeneCards Identifiers for TLCD2 Gene

  • GC17M001560
  • GC17M001505
  • GC17M001606

Summaries for TLCD2 Gene

GeneCards Summary for TLCD2 Gene

TLCD2 (TLC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is TLCD1.

Additional gene information for TLCD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLCD2 Gene

Genomics for TLCD2 Gene

GeneHancer (GH) Regulatory Elements for TLCD2 Gene

Promoters and enhancers for TLCD2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I001709 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 0.0 -33 2.1 ATF1 ARID4B SIN3A ZNF48 GLIS2 KLF7 ATF7 SP3 RXRA NFYC TLCD2 SERPINF2 GC17M001715 MIR22 MIR22HG
GH17I001712 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -5.3 -5336 7 MLX DMAP1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 WDR81 GC17M001715 MIR22HG MIR22 SMYD4 PRPF8 GEMIN4 RPA1 SERPINF2 METTL16
GH17I001721 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 -13.6 -13575 4.1 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 ZNF143 WDR81 SMYD4 PRPF8 RPA1 DPH1 RN7SL608P METTL16 SERPINF2 TLCD2 ENSG00000263050
GH17I001647 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.1 +60.8 60808 3.8 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF2 RILP SMYD4 METTL16 RPA1 HNRNPA1P16 DPH1 TLCD2 MIR22 WDR81 MIR22HG
GH17I001729 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.6 -20.2 -20224 2.4 SMAD1 ATF1 TAF9B NFRKB ZBTB40 TCF12 ZNF766 GATA2 EGR1 SCRT2 TLCD2 SERPINF2 SMYD4 RPA1 PAFAH1B1 ENSG00000262791 WDR81 MIR22HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TLCD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLCD2 gene promoter:

Genomic Locations for TLCD2 Gene

Genomic Locations for TLCD2 Gene
7,649 bases
Minus strand

Genomic View for TLCD2 Gene

Genes around TLCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLCD2 Gene

Proteins for TLCD2 Gene

  • Protein details for TLCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLC domain-containing protein 2
    Protein Accession:

    Protein attributes for TLCD2 Gene

    264 amino acids
    Molecular mass:
    28733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLCD2 Gene

Post-translational modifications for TLCD2 Gene

No Post-translational modifications

Other Protein References for TLCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLCD2 Gene

Domains & Families for TLCD2 Gene

Gene Families for TLCD2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TLCD2 Gene


Suggested Antigen Peptide Sequences for TLCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TLCD family.
  • Belongs to the TLCD family.
genes like me logo Genes that share domains with TLCD2: view

Function for TLCD2 Gene

Phenotypes From GWAS Catalog for TLCD2 Gene

Phenotypes for TLCD2 Gene

GenomeRNAi human phenotypes for TLCD2:
genes like me logo Genes that share phenotypes with TLCD2: view

miRNA for TLCD2 Gene

miRTarBase miRNAs that target TLCD2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLCD2 Gene

Localization for TLCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLCD2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLCD2 gene
Compartment Confidence
plasma membrane 3
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLCD2: view

Pathways & Interactions for TLCD2 Gene

SuperPathways for TLCD2 Gene

No Data Available

Interacting Proteins for TLCD2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: A6NGC4-TLCD2_HUMAN ENSP00000331965 for TLCD2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TLCD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TLCD2 Gene

Drugs & Compounds for TLCD2 Gene

No Compound Related Data Available

Transcripts for TLCD2 Gene

mRNA/cDNA for TLCD2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLCD2 Gene

TLC domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLCD2 Gene

No ASD Table

Relevant External Links for TLCD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLCD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLCD2 Gene

mRNA differential expression in normal tissues according to GTEx for TLCD2 Gene

This gene is overexpressed in Colon - Transverse (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TLCD2 Gene:


SOURCE GeneReport for Unigene cluster for TLCD2 Gene:


Evidence on tissue expression from TISSUES for TLCD2 Gene

  • Lung(2.2)
  • Liver(2)
genes like me logo Genes that share expression patterns with TLCD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TLCD2 Gene

Orthologs for TLCD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLCD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLCD2 33 34
  • 98.83 (n)
(Canis familiaris)
Mammalia TLCD2 33 34
  • 82.7 (n)
(Bos Taurus)
Mammalia TLCD2 33 34
  • 82.58 (n)
(Rattus norvegicus)
Mammalia Tlcd2 33
  • 78.38 (n)
(Mus musculus)
Mammalia Tlcd2 33 16 34
  • 77.47 (n)
(Monodelphis domestica)
Mammalia TLCD2 34
  • 49 (a)
(Gallus gallus)
Aves TLCD2 34
  • 44 (a)
(Anolis carolinensis)
Reptilia TLCD2 34
  • 41 (a)
(Danio rerio)
Actinopterygii tlcd2 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea Y48G8AL.13 34
  • 22 (a)
Y63D3A.8 34
  • 19 (a)
K12H6.6 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for TLCD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLCD2 Gene

Gene Tree for TLCD2 (if available)
Gene Tree for TLCD2 (if available)

Paralogs for TLCD2 Gene

Paralogs for TLCD2 Gene

(1) SIMAP similar genes for TLCD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TLCD2: view

Variants for TLCD2 Gene

Sequence variations from dbSNP and Humsavar for TLCD2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000072368 -- 1,710,432(-) G/A/C upstream_transcript_variant
rs1000073451 -- 1,709,560(-) G/C coding_sequence_variant, missense_variant
rs1000315653 -- 1,705,605(-) C/G 3_prime_UTR_variant
rs1000659602 -- 1,712,141(-) TTTTTTT/TTTTTTTT upstream_transcript_variant
rs1000813418 -- 1,707,294(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TLCD2 Gene

Variant ID Type Subtype PubMed ID
esv3639697 CNV loss 21293372
nsv470568 CNV loss 18288195
nsv516886 CNV loss 19592680
nsv827856 CNV gain 20364138
nsv9490 CNV loss 18304495

Variation tolerance for TLCD2 Gene

Gene Damage Index Score: 2.64; 45.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLCD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLCD2 Gene

Disorders for TLCD2 Gene

Additional Disease Information for TLCD2

No disorders were found for TLCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLCD2 Gene

Publications for TLCD2 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  2. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. (PMID: 16793762) Pewzner-Jung Y … Futerman AH (The Journal of biological chemistry 2006) 2 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 58

Products for TLCD2 Gene

Sources for TLCD2 Gene

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