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Aliases for TLCD2 Gene

Aliases for TLCD2 Gene

  • TLC Domain Containing 2 2 3 5

External Ids for TLCD2 Gene

Previous GeneCards Identifiers for TLCD2 Gene

  • GC17M001560
  • GC17M001505
  • GC17M001606

Summaries for TLCD2 Gene

GeneCards Summary for TLCD2 Gene

TLCD2 (TLC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is TLCD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLCD2 Gene

Genomics for TLCD2 Gene

Regulatory Elements for TLCD2 Gene

Enhancers for TLCD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TLCD2 on UCSC Golden Path with GeneCards custom track

Promoters for TLCD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TLCD2 Gene

1,702,790 bp from pter
1,710,438 bp from pter
7,649 bases
Minus strand

Genomic View for TLCD2 Gene

Genes around TLCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLCD2 Gene

Proteins for TLCD2 Gene

  • Protein details for TLCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TLC domain-containing protein 2
    Protein Accession:

    Protein attributes for TLCD2 Gene

    264 amino acids
    Molecular mass:
    28733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TLCD2 Gene

Post-translational modifications for TLCD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLCD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TLCD2 Gene

Domains & Families for TLCD2 Gene

Protein Domains for TLCD2 Gene


Suggested Antigen Peptide Sequences for TLCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Belongs to the TLCD family.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Belongs to the TLCD family.
genes like me logo Genes that share domains with TLCD2: view

No data available for Gene Families for TLCD2 Gene

Function for TLCD2 Gene

Phenotypes for TLCD2 Gene

GenomeRNAi human phenotypes for TLCD2:
genes like me logo Genes that share phenotypes with TLCD2: view

Animal Model Products

CRISPR Products

miRNA for TLCD2 Gene

miRTarBase miRNAs that target TLCD2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TLCD2 Gene

Localization for TLCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLCD2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TLCD2 Gene COMPARTMENTS Subcellular localization image for TLCD2 gene
Compartment Confidence
plasma membrane 3
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TLCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLCD2: view

Pathways & Interactions for TLCD2 Gene

SuperPathways for TLCD2 Gene

No Data Available

Interacting Proteins for TLCD2 Gene

Selected Interacting proteins: A6NGC4-TLCD2_HUMAN for TLCD2 Gene via IID

Gene Ontology (GO) - Biological Process for TLCD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TLCD2 Gene

Drugs & Compounds for TLCD2 Gene

No Compound Related Data Available

Transcripts for TLCD2 Gene

mRNA/cDNA for TLCD2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TLCD2 Gene

TLC domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLCD2 Gene

No ASD Table

Relevant External Links for TLCD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLCD2 Gene

mRNA expression in normal human tissues for TLCD2 Gene

mRNA differential expression in normal tissues according to GTEx for TLCD2 Gene

This gene is overexpressed in Colon - Transverse (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TLCD2 Gene:


SOURCE GeneReport for Unigene cluster for TLCD2 Gene:

genes like me logo Genes that share expression patterns with TLCD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TLCD2 Gene

Orthologs for TLCD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLCD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TLCD2 34
  • 82.58 (n)
  • 78.03 (a)
TLCD2 35
  • 78 (a)
(Canis familiaris)
Mammalia TLCD2 34
  • 82.7 (n)
  • 77.65 (a)
TLCD2 35
  • 77 (a)
(Mus musculus)
Mammalia Tlcd2 34
  • 77.47 (n)
  • 74.22 (a)
Tlcd2 16
Tlcd2 35
  • 58 (a)
(Pan troglodytes)
Mammalia TLCD2 34
  • 98.83 (n)
  • 98.05 (a)
TLCD2 35
  • 97 (a)
(Rattus norvegicus)
Mammalia Tlcd2 34
  • 78.38 (n)
  • 74.13 (a)
(Monodelphis domestica)
Mammalia TLCD2 35
  • 49 (a)
(Gallus gallus)
Aves TLCD2 35
  • 44 (a)
(Anolis carolinensis)
Reptilia TLCD2 35
  • 41 (a)
(Danio rerio)
Actinopterygii tlcd2 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea K12H6.6 35
  • 18 (a)
Y48G8AL.13 35
  • 22 (a)
Y63D3A.8 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
Species where no ortholog for TLCD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLCD2 Gene

Gene Tree for TLCD2 (if available)
Gene Tree for TLCD2 (if available)

Paralogs for TLCD2 Gene

Paralogs for TLCD2 Gene

(1) SIMAP similar genes for TLCD2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TLCD2: view

Variants for TLCD2 Gene

Sequence variations from dbSNP and Humsavar for TLCD2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3208963 -- 1,702,965(-) GTCCT(A/C)AAGAC utr-variant-3-prime
rs3208964 -- 1,702,948(-) CATGT(C/T)TACCA utr-variant-3-prime
rs3208965 -- 1,702,918(-) CTTTG(C/T)CCTCC utr-variant-3-prime
rs4790806 -- 1,706,493(+) GGGTA(C/T)GGTGG utr-variant-3-prime
rs4790807 -- 1,706,494(+) GGTAC(A/G)GTGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TLCD2 Gene

Variant ID Type Subtype PubMed ID
esv3639697 CNV loss 21293372
nsv470568 CNV loss 18288195
nsv516886 CNV loss 19592680
nsv827856 CNV gain 20364138
nsv9490 CNV loss 18304495

Variation tolerance for TLCD2 Gene

Gene Damage Index Score: 2.64; 45.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TLCD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLCD2 Gene

Disorders for TLCD2 Gene

Relevant External Links for TLCD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TLCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLCD2 Gene

Publications for TLCD2 Gene

  1. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis. (PMID: 16793762) Pewzner-Jung Y. … Futerman A.H. (J. Biol. Chem. 2006) 2 3 65
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65

Products for TLCD2 Gene

Sources for TLCD2 Gene

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