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Aliases for TLCD1 Gene

Aliases for TLCD1 Gene

  • TLC Domain Containing 1 2 3
  • TLC Domain-Containing Protein 1 3 4
  • Calfacilitin 3

External Ids for TLCD1 Gene

Previous GeneCards Identifiers for TLCD1 Gene

  • GC17M024076
  • GC17M027052
  • GC17M023260
  • GC17M027053
  • GC17M027140

Summaries for TLCD1 Gene

GeneCards Summary for TLCD1 Gene

TLCD1 (TLC Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TLCD2.

UniProtKB/Swiss-Prot for TLCD1 Gene

  • Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLCD1 Gene

Genomics for TLCD1 Gene

Regulatory Elements for TLCD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TLCD1 Gene

28,724,348 bp from pter
28,728,095 bp from pter
3,748 bases
Minus strand

Genomic View for TLCD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TLCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLCD1 Gene

Proteins for TLCD1 Gene

  • Protein details for TLCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MYP9

    Protein attributes for TLCD1 Gene

    247 amino acids
    Molecular mass:
    28548 Da
    Quaternary structure:
    • Interacts with CACNA1C.

    Alternative splice isoforms for TLCD1 Gene


neXtProt entry for TLCD1 Gene

Proteomics data for TLCD1 Gene at MOPED

Post-translational modifications for TLCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TLCD1 Gene

No data available for DME Specific Peptides for TLCD1 Gene

Domains for TLCD1 Gene

Protein Domains for TLCD1 Gene


Suggested Antigen Peptide Sequences for TLCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96CP7
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with TLCD1: view

No data available for Gene Families for TLCD1 Gene

Function for TLCD1 Gene

Molecular function for TLCD1 Gene

UniProtKB/Swiss-Prot Function: Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellular calcium by Calfacilitin is required for neural plate formation (By similarity).

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLCD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TLCD1 Gene

Localization for TLCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLCD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TLCD1 Gene COMPARTMENTS Subcellular localization image for TLCD1 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TLCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TLCD1: view

Pathways for TLCD1 Gene

SuperPathways for TLCD1 Gene

No Data Available

Interacting Proteins for TLCD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000292090 for TLCD1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TLCD1 Gene


No data available for Pathways by source for TLCD1 Gene

Transcripts for TLCD1 Gene

Unigene Clusters for TLCD1 Gene

TLC domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TLCD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLCD1 Gene

No ASD Table

Relevant External Links for TLCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TLCD1 Gene

mRNA expression in normal human tissues for TLCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TLCD1 Gene

SOURCE GeneReport for Unigene cluster for TLCD1 Gene Hs.499952

genes like me logo Genes that share expressions with TLCD1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TLCD1 Gene

Orthologs for TLCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TLCD1 35
  • 99.87 (n)
  • 99.6 (a)
TLCD1 36
  • 100 (a)
(Bos Taurus)
Mammalia TLCD1 35
  • 87.46 (n)
  • 89.32 (a)
TLCD1 36
  • 89 (a)
(Canis familiaris)
Mammalia TLCD1 35
  • 87.61 (n)
  • 89.74 (a)
TLCD1 36
  • 90 (a)
(Mus musculus)
Mammalia Tlcd1 35
  • 84.76 (n)
  • 87.61 (a)
Tlcd1 16
Tlcd1 36
  • 87 (a)
(Monodelphis domestica)
Mammalia TLCD1 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TLCD1 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Tlcd1 35
  • 84.19 (n)
  • 88.03 (a)
(Gallus gallus)
Aves TLCD1 35
  • 64.25 (n)
  • 58.12 (a)
TLCD1 36
  • 55 (a)
(Danio rerio)
Actinopterygii tlcd1 35
  • 51.39 (n)
  • 40.74 (a)
tlcd1 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea K12H6.6 36
  • 17 (a)
Y48G8AL.13 36
  • 18 (a)
Y63D3A.8 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for TLCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TLCD1 Gene

Gene Tree for TLCD1 (if available)
Gene Tree for TLCD1 (if available)

Paralogs for TLCD1 Gene

Paralogs for TLCD1 Gene

Selected SIMAP similar genes for TLCD1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TLCD1: view

Variants for TLCD1 Gene

Sequence variations from dbSNP and Humsavar for TLCD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2288595 -- 28,725,340(-) CAGAC(A/G)CGAGC synonymous-codon, reference
rs9910062 -- 28,726,312(+) ccgcc(C/T)gcccc intron-variant, upstream-variant-2KB
rs12937035 -- 28,726,595(+) GCCCT(A/C)TACTT intron-variant, upstream-variant-2KB
rs12952249 -- 28,726,550(+) CCACC(A/G)GCTAC intron-variant, upstream-variant-2KB
rs35498492 -- 28,725,721(+) TTCCC(-/C)AGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TLCD1 Gene

Variant ID Type Subtype PubMed ID
nsv908028 CNV Loss 21882294

Relevant External Links for TLCD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLCD1 Gene

Disorders for TLCD1 Gene

No disorders were found for TLCD1 Gene.

No data available for UniProtKB/Swiss-Prot for TLCD1 Gene

Publications for TLCD1 Gene

  1. TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains? (PMID: 12151215) Winter E. … Ponting C.P. (Trends Biochem. Sci. 2002) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for TLCD1 Gene

Sources for TLCD1 Gene

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