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Aliases for TKTL2 Gene

Aliases for TKTL2 Gene

  • Transketolase-Like 2 2 3
  • EC 2.2.1.1 4 63
  • Similar To Transketolase 2

External Ids for TKTL2 Gene

Previous GeneCards Identifiers for TKTL2 Gene

  • GC00U921650
  • GC04M164750
  • GC04M164611
  • GC04M164392
  • GC04M160146

Summaries for TKTL2 Gene

GeneCards Summary for TKTL2 Gene

TKTL2 (Transketolase-Like 2) is a Protein Coding gene. Diseases associated with TKTL2 include nasopharyngitis and nasopharyngeal disease. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor and transketolase activity. An important paralog of this gene is TKT.

UniProtKB/Swiss-Prot for TKTL2 Gene

  • Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.

Gene Wiki entry for TKTL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TKTL2 Gene

Genomics for TKTL2 Gene

Regulatory Elements for TKTL2 Gene

Genomic Location for TKTL2 Gene

Chromosome:
4
Start:
163,471,093 bp from pter
End:
163,473,895 bp from pter
Size:
2,803 bases
Orientation:
Minus strand

Genomic View for TKTL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TKTL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TKTL2 Gene

Proteins for TKTL2 Gene

  • Protein details for TKTL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0I9-TKTL2_HUMAN
    Recommended name:
    Transketolase-like protein 2
    Protein Accession:
    Q9H0I9
    Secondary Accessions:
    • A4FVB4
    • Q8NCT0
    • Q96M82

    Protein attributes for TKTL2 Gene

    Size:
    626 amino acids
    Molecular mass:
    67877 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).;
    Cofactor:
    Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Note=Binds 1 thiamine pyrophosphate per subunit.;
    Quaternary structure:
    • Homodimer.

neXtProt entry for TKTL2 Gene

Proteomics data for TKTL2 Gene at MOPED

Post-translational modifications for TKTL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TKTL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for TKTL2 Gene

Suggested Antigen Peptide Sequences for TKTL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0I9

UniProtKB/Swiss-Prot:

TKTL2_HUMAN :
  • Belongs to the transketolase family.
Family:
  • Belongs to the transketolase family.
genes like me logo Genes that share domains with TKTL2: view

No data available for Gene Families for TKTL2 Gene

Function for TKTL2 Gene

Molecular function for TKTL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
UniProtKB/Swiss-Prot Function:
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.

Enzyme Numbers (IUBMB) for TKTL2 Gene

Gene Ontology (GO) - Molecular Function for TKTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004802 transketolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TKTL2: view

Phenotypes for TKTL2 Gene

genes like me logo Genes that share phenotypes with TKTL2: view

Animal Model Products

miRNA for TKTL2 Gene

miRTarBase miRNAs that target TKTL2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TKTL2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TKTL2 Gene

Localization for TKTL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TKTL2 Gene COMPARTMENTS Subcellular localization image for TKTL2 gene
Compartment Confidence
peroxisome 1

Gene Ontology (GO) - Cellular Components for TKTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TKTL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TKTL2 Gene

Pathways & Interactions for TKTL2 Gene

genes like me logo Genes that share pathways with TKTL2: view

Gene Ontology (GO) - Biological Process for TKTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TKTL2: view

No data available for SIGNOR curated interactions for TKTL2 Gene

Drugs & Compounds for TKTL2 Gene

(4) Drugs for TKTL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceraldehyde-3-Phosphate Experimental Pharma 0
thiamin diphosphate Experimental Pharma 0
Calcium Nutra 0
Magnesium Nutra 0

(9) Additional Compounds for TKTL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aminofructose 6-phosphate
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
  • D-Erythrose 4-PO4
  • D-Erythrose-4-P
  • D-Erythrose-4-phosphate
  • Erythrose 4-phosphate
585-18-2
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
D-Ribulose 5-phosphate
  • alpha-D-Ribose 5-phosphate
  • D-Ribulose 5-phosphate
  • Erythro-Pentulose 5-phosphate
  • Ribulose 5-phosphate
  • Ribulose phosphate
4151-19-3
genes like me logo Genes that share compounds with TKTL2: view

Transcripts for TKTL2 Gene

mRNA/cDNA for TKTL2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TKTL2 Gene

Transketolase-like 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TKTL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TKTL2 Gene

No ASD Table

Relevant External Links for TKTL2 Gene

GeneLoc Exon Structure for
TKTL2
ECgene alternative splicing isoforms for
TKTL2

Expression for TKTL2 Gene

mRNA expression in normal human tissues for TKTL2 Gene

mRNA differential expression in normal tissues according to GTEx for TKTL2 Gene

This gene is overexpressed in Testis (x49.8).

Protein differential expression in normal tissues from HIPED for TKTL2 Gene

This gene is overexpressed in Testis (45.6) and Ovary (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TKTL2 Gene



SOURCE GeneReport for Unigene cluster for TKTL2 Gene Hs.303923

mRNA Expression by UniProt/SwissProt for TKTL2 Gene

Q9H0I9-TKTL2_HUMAN
Tissue specificity: Overexpressed in hepatoma cancer cells.
genes like me logo Genes that share expression patterns with TKTL2: view

Protein tissue co-expression partners for TKTL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TKTL2 Gene

Orthologs for TKTL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TKTL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TKTL2 35
  • 83.52 (n)
  • 81.12 (a)
TKTL2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tktl2 35
  • 80.91 (n)
  • 80.64 (a)
Tktl2 16
Tktl2 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TKTL2 35
  • 99.63 (n)
  • 99.36 (a)
TKTL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tktl2 35
  • 80.59 (n)
  • 81.6 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 71 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76292 35
tktl2 35
  • 71.09 (n)
  • 73.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69114 35
zebrafish
(Danio rerio)
Actinopterygii tkt 35
tktb 35
  • 68.61 (n)
  • 70.06 (a)
tktb 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10494 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011161 35
  • 58.13 (n)
  • 59.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8036 35
  • 59.79 (n)
  • 60.39 (a)
CG5103 36
  • 51 (a)
ManyToMany
CG8036 36
  • 59 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tkt-1 35
  • 60.07 (n)
  • 59.73 (a)
tkt-1 36
  • 58 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TKL1 36
  • 23 (a)
ManyToMany
TKL2 36
  • 21 (a)
ManyToMany
Species with no ortholog for TKTL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TKTL2 Gene

ENSEMBL:
Gene Tree for TKTL2 (if available)
TreeFam:
Gene Tree for TKTL2 (if available)

Paralogs for TKTL2 Gene

Paralogs for TKTL2 Gene

(3) SIMAP similar genes for TKTL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TKTL2: view

Variants for TKTL2 Gene

Sequence variations from dbSNP and Humsavar for TKTL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_031990 -
VAR_031991 -

Variation tolerance for TKTL2 Gene

Residual Variation Intolerance Score: 78.94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TKTL2 Gene

HapMap Linkage Disequilibrium report
TKTL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TKTL2 Gene

Disorders for TKTL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TKTL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nasopharyngitis
  • chronic nasopharyngitis
nasopharyngeal disease
  • disorder of nasopharynx
- elite association
Search TKTL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TKTL2

Genetic Association Database (GAD)
TKTL2
Human Genome Epidemiology (HuGE) Navigator
TKTL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TKTL2
genes like me logo Genes that share disorders with TKTL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TKTL2 Gene

Publications for TKTL2 Gene

  1. A review on research progress of transketolase. (PMID: 19290028) Zhao J. … Zhong C.J. (Neurosci Bull 2009) 23 67
  2. Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: a potential therapeutic target in nasopharyngeal carcinoma. (PMID: 18296915) Zhang S. … Kong W.J. (Cancer Biol. Ther. 2008) 23 67
  3. [Effects of transketolase-like gene TKTL1 on occurrence and metastasis of human nasopharyngeal carcinoma]. (PMID: 19159596) Zhang S. … Cai P.C. (Zhonghua Yi Xue Za Zhi 2008) 23 67
  4. Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. (PMID: 17321041) Zhang S. … Cai P.-C. (Cancer Lett. 2007) 23 67
  5. Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas. (PMID: 17639446) VAPlker H.U. … Eck M. (Eur Arch Otorhinolaryngol 2007) 23 67

Products for TKTL2 Gene

Sources for TKTL2 Gene

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