TKTL2 Gene
protein-coding GIFtS: 55
GCID: GC04M164392
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transketolase-like 2
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Aliases
for TKTL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transketolase-Like 21 2 | | EC 2.2.1.13 8 | | DKFZP434L17171 | | FLJ329751 | | Transketolase-Like Protein 22 |
Export aliases for TKTL2 gene to outside databasesPrevious GC identifers: GC00U921650 GC04M164750 GC04M164611 GC04M160146 |
Summaries
for TKTL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9Function: Plays an essential role in total transketolase activity and cell proliferation in cancer cells; aftertransfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation wassignificantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis
Gene Wiki entry for TKTL2
|
Genomic Views
for TKTL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TKTL2 gene promoter:
SRF COUP-TF1 RREB-1 SRF (504 AA) COUP HNF-4alpha2 HNF-4alpha1 N-Myc S8 COUP-TF
Other transcription factors
Search SABiosciences Chromatin IP Primers for TKTL2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TKTL2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.2 Ensembl cytogenetic band: 4q32.2 HGNC cytogenetic band: 4q32.2TKTL2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M164392: view genomic region
(about GC identifiers)
Start:
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164,392,247 bp from pter |
End:
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164,395,047 bp from pter |
Size:
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2,801 bases |
Orientation:
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minus strand |
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Proteins
for TKTL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9 (See
protein sequence)Recommended Name: Transketolase-like protein 2 Size: 626 amino acids; 67877 Da
Cofactor: Binds 1 magnesium ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) andCo(2+) (By similarity)
Cofactor: Binds 1 thiamine pyrophosphate per subunit (By similarity)
Subunit: Homodimer (By similarity)
Secondary accessions: A4FVB4 Q8NCT0 Q96M82Explore the universe of human proteins at neXtProt for TKTL2: NX_Q9H0I9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0I9
4/16 DME Specific Peptides for TKTL2 (Q9H0I9) (see all 16)
TKTL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115512.3
ENSEMBL proteins: ENSP00000280605
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- |
TKTL2 for ontologies About GeneDecksing
TKTL2 Antibody Products:
Assay Products for TKTL2: |
Protein
Domains /
Families
for TKTL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TKTL2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0I9ProtoNet protein and cluster: Q9H0I9 2 Blocks protein families: IPB005475 Transketolase IPB005476 Transketolase
UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9Similarity: Belongs to the transketolase family |
Function
for TKTL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9Function: Plays an essential role in total transketolase activity and cell proliferation in cancer cells; aftertransfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation wassignificantly inhibited in cancer cells. Plays a pivotal role in carcinogenesisCatalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose5-phosphateEnzyme Number (IUBMB): EC 2.2.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TKTL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TKTL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TKTL2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKTL2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKTL2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004802 | transketolase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
TKTL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TKTL2:
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Pathways & Interactions
for TKTL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pentose phosphate pathway (hexose monophosphate shunt) | | | 2 | Pentose phosphate pathway | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for TKTL2
2 
Kegg Pathways (Kegg details for TKTL2):
TKTL2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TKTL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/47 Interacting proteins for TKTL2 (Q9H0I92, 3 ENSP000002806054) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
|
Drugs & Compounds
for TKTL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TKTL2
10 HMDB Compounds for TKTL2 About this table
Search CenterWatch for drugs/clinical trials and news about TKTL2
|
Transcripts
for TKTL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TKTL2 gene: NM_032136.4 Unigene Cluster for TKTL2: Transketolase-like 2 Hs.303923 [show with all ESTs]Unigene Representative Sequence: NM_0321361 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000280605(uc003iqp.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TKTL2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TKTL2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TKTL2 (NM_032136) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TKTL2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKTL2 |
Additional cDNA sequence: AK057325.1 AK057537.1 AK098582.1 AK314517.1 AL136779.1 AL834334.1 BC028707.2 BC125101.1 BC142943.1 CR533560.1 1 DOTS entry: DT.400324 24/54 AceView cDNA sequences (see all 54): AK057537 AW081754 CR533560 AA824380 AW665029 CB857892 AI191944 AW511131 BX105345 AI147964 AL136779 AI968423 AI150155 AK057325 NM_032136 BC028707 BI462360 CD244614 BG722398 BU853679 BG772842 BI463525 BG723192 AI142252
GeneLoc Exon Structure
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Expression
for TKTL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TKTL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCCTTAGA
About this image
See TKTL2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TKTL2
SOURCE GeneReport for Unigene cluster: Hs.303923
UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9Tissue specificity: Overexpressed in hepatoma cancer cells
SABiosciences Custom PCR Arrays for TKTL2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TKTL2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TKTL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TKTL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TKTL2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKTL2 |
Orthologs
for TKTL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TKTL2 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for TKTL2 (if available)
TreeFam Gene Tree for TKTL2 (if available) |
Paralogs
for TKTL2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TKTL2 gene
- TKTL12 TKT2
3 SIMAP similar genes for TKTL2 using alignment to 1 protein entry: TKTL2_HUMAN:DKFZp434B129 TKTL1 TKT
TKTL2 for paralogs About GeneDecksing
|
Genomic Variants
for TKTL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TKTL2 |
|
Disorders
/ Diseases
for TKTL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TKTL2 for disorders About GeneDecksing
10  diseases for TKTL2: About MalaCardswernicke-korsakoff syndrome laryngeal squamous cell carcinoma squamous cell carcinoma laryngitis
nasopharyngitis pneumonia carcinoma tuberculosis
malaria mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for TKTL2:Nasopharyngitis Human Genome Epidemiology (HuGE) Navigator: TKTL2 (1 document)
Export disorders for TKTL2 gene to outside databases
|
Publications
for TKTL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TKTL2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TKTL2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. (PubMed id 17321041)2, 9 Zhang S....Cai P.C. (2007)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TKTL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TKTL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TKTL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TKTL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TKTL2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TKTL2 gene:
Search GeneIP for patents involving TKTL2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TKTL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TKTL2 | | OriGene shRNA RFP for TKTL2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TKTL2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TKTL2 | | | OriGene Protein Over-expression Lysate for TKTL2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TKTL2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TKTL2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TKTL2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TKTL2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TKTL2 | | OriGene Custom Protein Services for TKTL2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TKTL2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TKTL2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TKTL2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TKTL2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TKTL2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TKTL2 |
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 | | | TKTL2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKTL2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TKTL2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKTL2 |
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