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Aliases for TKTL2 Gene

Aliases for TKTL2 Gene

  • Transketolase-Like 2 2 3 5
  • EC 4 63
  • Similar To Transketolase 2

External Ids for TKTL2 Gene

Previous GeneCards Identifiers for TKTL2 Gene

  • GC00U921650
  • GC04M164750
  • GC04M164611
  • GC04M164392
  • GC04M160146

Summaries for TKTL2 Gene

GeneCards Summary for TKTL2 Gene

TKTL2 (Transketolase-Like 2) is a Protein Coding gene. Diseases associated with TKTL2 include Nasopharyngeal Disease. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor and transketolase activity. An important paralog of this gene is TKT.

UniProtKB/Swiss-Prot for TKTL2 Gene

  • Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.

Gene Wiki entry for TKTL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TKTL2 Gene

Genomics for TKTL2 Gene

Regulatory Elements for TKTL2 Gene

Enhancers for TKTL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TKTL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TKTL2 Gene

163,471,093 bp from pter
163,473,895 bp from pter
2,803 bases
Minus strand

Genomic View for TKTL2 Gene

Genes around TKTL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TKTL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TKTL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TKTL2 Gene

Proteins for TKTL2 Gene

  • Protein details for TKTL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transketolase-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A4FVB4
    • Q8NCT0
    • Q96M82

    Protein attributes for TKTL2 Gene

    626 amino acids
    Molecular mass:
    67877 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
    Quaternary structure:
    • Homodimer.

neXtProt entry for TKTL2 Gene

Proteomics data for TKTL2 Gene at MOPED

Post-translational modifications for TKTL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TKTL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TKTL2 Gene

Suggested Antigen Peptide Sequences for TKTL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the transketolase family.
  • Belongs to the transketolase family.
genes like me logo Genes that share domains with TKTL2: view

No data available for Gene Families for TKTL2 Gene

Function for TKTL2 Gene

Molecular function for TKTL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
UniProtKB/Swiss-Prot Function:
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.

Enzyme Numbers (IUBMB) for TKTL2 Gene

Gene Ontology (GO) - Molecular Function for TKTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004802 transketolase activity IEA --
genes like me logo Genes that share ontologies with TKTL2: view
genes like me logo Genes that share phenotypes with TKTL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TKTL2

miRNA for TKTL2 Gene

miRTarBase miRNAs that target TKTL2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TKTL2 Gene

Localization for TKTL2 Gene

Subcellular locations from

Jensen Localization Image for TKTL2 Gene COMPARTMENTS Subcellular localization image for TKTL2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TKTL2 Gene

Pathways & Interactions for TKTL2 Gene

genes like me logo Genes that share pathways with TKTL2: view

Pathways by source for TKTL2 Gene

Gene Ontology (GO) - Biological Process for TKTL2 Gene


No data available for SIGNOR curated interactions for TKTL2 Gene

Drugs & Compounds for TKTL2 Gene

(4) Drugs for TKTL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceraldehyde-3-Phosphate Experimental Pharma 0
thiamin diphosphate Experimental Pharma 0
calcium Nutra 0
Magnesium Nutra 0

(9) Additional Compounds for TKTL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aminofructose 6-phosphate
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
  • D-Erythrose 4-PO4
  • D-Erythrose-4-P
  • D-Erythrose-4-phosphate
  • Erythrose 4-phosphate
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
D-Ribulose 5-phosphate
  • alpha-D-Ribose 5-phosphate
  • D-Ribulose 5-phosphate
  • Erythro-Pentulose 5-phosphate
  • Ribulose 5-phosphate
  • Ribulose phosphate
genes like me logo Genes that share compounds with TKTL2: view

Transcripts for TKTL2 Gene

mRNA/cDNA for TKTL2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TKTL2 Gene

Transketolase-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TKTL2 Gene

No ASD Table

Relevant External Links for TKTL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TKTL2 Gene

mRNA expression in normal human tissues for TKTL2 Gene

mRNA differential expression in normal tissues according to GTEx for TKTL2 Gene

This gene is overexpressed in Testis (x49.8).

Protein differential expression in normal tissues from HIPED for TKTL2 Gene

This gene is overexpressed in Testis (45.6) and Ovary (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TKTL2 Gene

SOURCE GeneReport for Unigene cluster for TKTL2 Gene Hs.303923

mRNA Expression by UniProt/SwissProt for TKTL2 Gene

Tissue specificity: Overexpressed in hepatoma cancer cells.
genes like me logo Genes that share expression patterns with TKTL2: view

Protein tissue co-expression partners for TKTL2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TKTL2 Gene

Orthologs for TKTL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TKTL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TKTL2 35
  • 83.52 (n)
  • 81.12 (a)
TKTL2 36
  • 81 (a)
(Mus musculus)
Mammalia Tktl2 35
  • 80.91 (n)
  • 80.64 (a)
Tktl2 16
Tktl2 36
  • 80 (a)
(Pan troglodytes)
Mammalia TKTL2 35
  • 99.63 (n)
  • 99.36 (a)
TKTL2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tktl2 35
  • 80.59 (n)
  • 81.6 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
-- 36
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76292 35
tktl2 35
  • 71.09 (n)
  • 73.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69114 35
(Danio rerio)
Actinopterygii tkt 35
tktb 35
  • 68.61 (n)
  • 70.06 (a)
tktb 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10494 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011161 35
  • 58.13 (n)
  • 59.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8036 35
  • 59.79 (n)
  • 60.39 (a)
CG5103 36
  • 51 (a)
CG8036 36
  • 59 (a)
(Caenorhabditis elegans)
Secernentea tkt-1 35
  • 60.07 (n)
  • 59.73 (a)
tkt-1 36
  • 58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TKL1 36
  • 23 (a)
TKL2 36
  • 21 (a)
Species with no ortholog for TKTL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TKTL2 Gene

Gene Tree for TKTL2 (if available)
Gene Tree for TKTL2 (if available)

Paralogs for TKTL2 Gene

Paralogs for TKTL2 Gene

(3) SIMAP similar genes for TKTL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TKTL2: view

Variants for TKTL2 Gene

Sequence variations from dbSNP and Humsavar for TKTL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3811750 - 163,472,410(+) TGCTT(C/T)GGAAC reference, missense
rs11735477 - 163,471,965(+) GCCAG(A/T)TGATG reference, missense
rs9991138 -- 163,470,813(+) AATTT(A/G)GTTTG downstream-variant-500B
rs9308060 -- 163,471,073(+) CCCAC(A/G)TACAC downstream-variant-500B
rs11944657 -- 163,475,723(+) CACTA(A/C)TGATT upstream-variant-2KB

Variation tolerance for TKTL2 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TKTL2 Gene

Disorders for TKTL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TKTL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nasopharyngeal disease
  • nasopharyngeal diseases
- elite association - COSMIC cancer census association via MalaCards
Search TKTL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TKTL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TKTL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TKTL2 Gene

Publications for TKTL2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3
  4. A review on research progress of transketolase. (PMID: 19290028) Zhao J. … Zhong C.J. (Neurosci Bull 2009) 23
  5. Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: a potential therapeutic target in nasopharyngeal carcinoma. (PMID: 18296915) Zhang S. … Kong W.J. (Cancer Biol. Ther. 2008) 23

Products for TKTL2 Gene

Sources for TKTL2 Gene