Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TKTL2 Gene

protein-coding   GIFtS: 57
GCID: GC04M164392

Transketolase-Like 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transketolase-Like 21 2
EC 2.2.1.13 8
Similar To Transketolase1
Transketolase-Like Protein 22

External Ids:    HGNC: 253131   Entrez Gene: 840762   Ensembl: ENSG000001510057   UniProtKB: Q9H0I93   

Export aliases for TKTL2 gene to outside databases

Previous GC identifers: GC00U921650 GC04M164750 GC04M164611 GC04M160146


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TKTL2 Gene: 
TKTL2 (transketolase-like 2) is a protein-coding gene. Diseases associated with TKTL2 include wernicke-korsakoff syndrome, and laryngeal squamous cell carcinoma, and among its related super-pathways are pentose phosphate pathway and Biosynthesis of amino acids. GO annotations related to this gene include metal ion binding and transketolase activity. An important paralog of this gene is TKTL1.

UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9
Function: Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after
transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was
significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis

Gene Wiki entry for TKTL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TKTL2 gene promoter:
         SRF   COUP-TF1   RREB-1   SRF (504 AA)   COUP   HNF-4alpha2   HNF-4alpha1   N-Myc   S8   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTKTL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TKTL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TKTL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.2   Ensembl cytogenetic band:  4q32.2   HGNC cytogenetic band: 4q32.2

TKTL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TKTL2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M164392:  view genomic region     (about GC identifiers)

Start:
164,392,247 bp from pter      End:
164,395,047 bp from pter
Size:
2,801 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9 (See protein sequence)
Recommended Name: Transketolase-like protein 2  
Size: 626 amino acids; 67877 Da
Cofactor: Binds 1 magnesium ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+)
and Co(2+) (By similarity)
Cofactor: Binds 1 thiamine pyrophosphate per subunit (By similarity)
Subunit: Homodimer (By similarity)
Secondary accessions: A4FVB4 Q8NCT0 Q96M82

Explore the universe of human proteins at neXtProt for TKTL2: NX_Q9H0I9

Explore proteomics data for TKTL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0I9

  • 4/16 DME Specific Peptides for TKTL2 (Q9H0I9) (see all 16)
     GGIGEAV  GSHCGVS  DKASYRV  VLFFHTM 

    TKTL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TKTL2 Protein Expression
    REFSEQ proteins: NP_115512.3  
    ENSEMBL proteins: 
     ENSP00000280605  

    Human Recombinant Protein Products for TKTL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TKTL2
    OriGene Protein Over-expression Lysate for TKTL2
    OriGene MassSpec for TKTL2 
    OriGene Custom Protein Services for TKTL2
    GenScript Custom Purified and Recombinant Proteins Services for TKTL2
    Novus Biologicals TKTL2 Protein
    Novus Biologicals TKTL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TKTL2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    TKTL2 for ontologies           About GeneDecksing



    TKTL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TKTL2
    OriGene Custom Antibody Services for TKTL2
    GenScript Custom Superior Antibodies Services for TKTL2
    Novus Biologicals TKTL2 Antibodies
    Abcam antibodies for TKTL2
    Cloud-Clone Corp. Antibodies for TKTL2 
    ThermoFisher Antibodies for TKTL2
    LSBio Antibodies in human, mouse, rat for TKTL2 

    Assay Products for TKTL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TKTL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TKTL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TKTL2 
    Cloud-Clone Corp. CLIAs for TKTL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR005474 Transketolase_N
     IPR005476 Transketolase_C
     IPR009014 Transketo_C/Pyr-ferredox_oxred
     IPR005475 Transketolase-like_Pyr-bd
     IPR015941 Transketolase-like_C

    Graphical View of Domain Structure for InterPro Entry Q9H0I9

    ProtoNet protein and cluster: Q9H0I9

    2 Blocks protein domains:
    IPB005475 Transketolase
    IPB005476 Transketolase


    UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9
    Similarity: Belongs to the transketolase family


    TKTL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TKTL2_HUMAN, Q9H0I9
    Function: Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after
    transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was
    significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis
    Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose
    5-phosphate

         Enzyme Number (IUBMB): EC 2.2.1.11 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004802transketolase activity IEA--
    GO:0016624oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor ----
    GO:0046872metal ion binding IEA--
         
    TKTL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TKTL2:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TKTL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TKTL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TKTL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TKTL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TKTL2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TKTL2
    SwitchGear 3'UTR luciferase reporter plasmidTKTL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TKTL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TKTL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TKTL2
    Sirion Biotech Customized adenovirus for overexpression of TKTL2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TKTL2 (see all 6)
    OriGene ORF clones in mouse, rat for TKTL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TKTL2 (NM_032136)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TKTL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKTL2
    Sirion Biotech Customized lentivirus for stable overexpression of TKTL2 
                         Customized lentivirus expression plasmids for stable overexpression of TKTL2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TKTL2
    Search LifeMap BioReagents cell lines for TKTL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKTL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TKTL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Pentose phosphate pathway (hexose monophosphate shunt)
    pentose phosphate pathway0.67
    pentose phosphate pathway (non-oxidative branch)0.62
    2Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37
    3Metabolism
    Metabolic pathways0.40
    4Pentose phosphate pathway
    Pentose phosphate pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TKTL2
        pentose phosphate pathway
    pentose phosphate pathway (non-oxidative branch)


    4         Kegg Pathways  (Kegg details for TKTL2):
        Pentose phosphate pathway
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids


    TKTL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TKTL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for TKTL2 (Q9H0I92, 3 ENSP000002806054) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFICP086512, 3, ENSP000003968434MINT-67467 I2D: score=4 STRING: ENSP00000396843
    DERAENSP000004165834STRING: ENSP00000416583
    FBP1ENSP000003644754STRING: ENSP00000364475
    FBP2ENSP000003644864STRING: ENSP00000364486
    GPIENSP000003488774STRING: ENSP00000348877
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    TKTL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TKTL2

    10 HMDB Compounds for TKTL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    CalciumCa (see all 2)7440-70-2--
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Ribose 5-phosphateD-Ribose 5-phosphate (see all 11)3615-55-2--
    D-Ribulose 5-phosphateD-Ribulose 5-phosphate (see all 5)4151-19-3--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    MagnesiumMagnesium (see all 2)7439-95-4--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--
    Thiamine pyrophosphateTPP (see all 11)154-87-0--
    Xylulose 5-phosphateD-xylulose-5-P (see all 9)4212-65-1--

    Search CenterWatch for drugs/clinical trials and news about TKTL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TKTL2 gene: 
    NM_032136.4  

    Unigene Cluster for TKTL2:

    Transketolase-like 2
    Hs.303923  [show with all ESTs]
    Unigene Representative Sequence: NM_032136
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000280605(uc003iqp.4)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TKTL2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TKTL2
    SwitchGear 3'UTR luciferase reporter plasmidTKTL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TKTL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TKTL2
    Clone
    Products:
         
    OriGene clones in human, mouse for TKTL2 (see all 6)
    OriGene ORF clones in mouse, rat for TKTL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TKTL2 (NM_032136)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TKTL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKTL2
    Sirion Biotech Customized lentivirus for stable overexpression of TKTL2 
                         Customized lentivirus expression plasmids for stable overexpression of TKTL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TKTL2
    OriGene qSTAR qPCR primer pairs in human, mouse for TKTL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TKTL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TKTL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TKTL2

    Additional mRNA sequence: 

    AK057325.1 AK057537.1 AK098582.1 AK314517.1 AL136779.1 AL834334.1 BC028707.2 BC125101.1 
    BC142943.1 CR533560.1 

    1 DOTS entry:

    DT.400324 

    24/54 AceView cDNA sequences (see all 54):

    BX105345 AW511131 AI150155 AI968423 AW081754 AI191944 AL136779 AI147964 
    CB857892 AA824380 CR533560 AK057537 AW665029 BG771864 AI142252 AI204394 
    BI462360 BU853679 BI830462 BC028707 AI018700 AA905883 NM_032136 BI829125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TKTL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCTTAGA
    TKTL2 Expression
    About this image


    See TKTL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TKTL2

    SOURCE GeneReport for Unigene cluster: Hs.303923

    UniProtKB/Swiss-Prot: TKTL2_HUMAN, Q9H0I9
    Tissue specificity: Overexpressed in hepatoma cancer cells

        SABiosciences Custom PCR Arrays for TKTL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TKTL2
    OriGene qSTAR qPCR primer pairs in human, mouse for TKTL2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TKTL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TKTL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TKTL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKTL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TKTL2 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tktl21 , 5 transketolase-like 21, 5 80.91(n)1
    80.64(a)1
      8 (33.14 cM)5
    744191  NM_028927.31  NP_083203.21 
     665117565 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    2(88688147-88704999)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691142 transketolase 75.82(n)    AF270484.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tkt2 transketolase 75.15(n)   378713  AY422993.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80361 CG8036 59.38(n)
    60.03(a)
      41027  NM_141555.1  NP_649812.2 
    worm
    (Caenorhabditis elegans)
    Secernentea tkt-11 Protein TKT-1 59.63(n)
    59.3(a)
      177906  NM_069477.2  NP_501878.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TKL16
    TKL26
    Transketolase, similar to Tkl2p; catalyzes convers...
    Transketolase, similar to Tkl1p; catalyzes convers...
    22(a)
    20(a)
    many ↔ many
    many ↔ many
    XVI(692796-694838)
    II(474392-476437)


    ENSEMBL Gene Tree for TKTL2 (if available)
    TreeFam Gene Tree for TKTL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TKTL2 gene
    TKTL12  TKT2  
    3 SIMAP similar genes for TKTL2 using alignment to 1 protein entry:     TKTL2_HUMAN:
    DKFZp434B129    TKTL1    TKT

    TKTL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/174 SNPs in TKTL2 are shown (see all 174)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866164261,2
    --164391890(+) GTTATG/TCCTCC 1 -- int10--------
    rs99911381,2
    C,F--164391965(+) AATTTA/GGTTTG 1 -- int11Minor allele frequency- G:0.06WA 118
    rs1910725791,2
    --164391974(+) TGGAAA/CCTTGG 1 -- int10--------
    rs1835420571,2
    --164391981(+) TTGGGA/TCCATC 1 -- int10--------
    rs1419176211,2
    C--164391983(+) GGGTCC/TATCTA 1 -- int10--------
    rs1878059161,2
    --164391988(+) CATCTA/GTGATT 1 -- int10--------
    rs93080601,2
    C,F,A,H--164392225(+) CCCACA/GTACAC 1 -- int118Minor allele frequency- G:0.22NS EA NA WA 2336
    rs1929706391,2
    --164392406(+) CTTTCA/GTCACT 1 -- ut310--------
    rs286526751,2
    C--164392482(+) GTAGAA/GGAGAG 1 -- ut310--------
    rs1851381021,2
    C--164392602(+) GGACTA/TTTGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TKTL2 (164392247 - 164395047 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TKTL2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TKTL2
    DNA2.0 Custom Variant and Variant Library Synthesis for TKTL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for TKTL2:    About MalaCards
    wernicke-korsakoff syndrome    laryngeal squamous cell carcinoma    nasopharyngitis    laryngitis
    pneumonia    tuberculosis    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for TKTL2:
    Nasopharyngitis

    TKTL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TKTL2
    Human Genome Epidemiology (HuGE) Navigator: TKTL2 (1 document)

    Export disorders for TKTL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TKTL2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with TKTL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. (PubMed id 17321041)2, 9 Zhang S....Cai P.C. (2007)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84076 HGNC: 25313 AceView: DKFZP434L1717 Ensembl:ENSG00000151005 euGenes: HUgn84076
    ECgene: TKTL2 Kegg: 84076 H-InvDB: TKTL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TKTL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TKTL2 gene:
    Search GeneIP for patents involving TKTL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TKTL2   OriGene RNAi products in human, mouse, rat for TKTL2  
     OriGene qPCR primer pairs and template standards for TKTL2   OriGene Protein Over-expression Lysate for TKTL2  
     OriGene MassSpec something-or-other for TKTL2   OriGene clones in human, mouse for TKTL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for TKTL2   OriGene Purified Protein for TKTL2  
     OriGene ORF clones in mouse, rat for TKTL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TKTL2   OriGene Custom Protein Services for TKTL2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TKTL2
     QIAGEN SeqTarget long-range PCR primers for resequencing TKTL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TKTL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TKTL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TKTL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TKTL2
     GenScript Custom Purified and Recombinant Proteins Services for TKTL2 GenScript cDNA clones with any tag delivered in your preferred vector for TKTL2
     GenScript Custom Assay Services for TKTL2 GenScript Custom Superior Antibodies Services for TKTL2
     GenScript Custom overexpressing Cell Line Services for TKTL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TKTL2 promoter
     Search Chromatin IP Primers for TKTL2
     RT2 qPCR Primer Assay in human, mouse, rat TKTL2
     Search GNC Networks for TKTL2
     SABiosciences Custom PCR Arrays for TKTL2
     Search Tocris compounds for TKTL2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TKTL2 antibodies
     TKTL2 proteins
     TKTL2 lysates
     Antibodies for TKTL2
     See all of Abcam's Antibodies, Kits and Proteins for TKTL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TKTL2
     Antibodies for TKTL2
     ELISAs for TKTL2
     CLIAs for TKTL2
     Search LifeMap BioReagents cell lines for TKTL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKTL2
     SwitchGear 3'UTR luciferase reporter plasmids for TKTL2
     SwitchGear Promoter luciferase reporter plasmids for TKTL2
     ThermoFisher Antibodies for TKTL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKTL2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TKTL2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TKTL2
    Customized:
     lentivirus for stable overexpression of TKTL2
     lentivirus expression plasmids for stable overexpression of TKTL2
     adenovirus for overexpression of TKTL2
     LSBio Antibodies in human, mouse, rat for TKTL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TKTL2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4