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Aliases for TKTL2 Gene

Aliases for TKTL2 Gene

  • Transketolase Like 2 2 3 5
  • EC 2.2.1.1 4 61
  • Similar To Transketolase 2

External Ids for TKTL2 Gene

Previous GeneCards Identifiers for TKTL2 Gene

  • GC00U921650
  • GC04M164750
  • GC04M164611
  • GC04M164392
  • GC04M160146

Summaries for TKTL2 Gene

GeneCards Summary for TKTL2 Gene

TKTL2 (Transketolase Like 2) is a Protein Coding gene. Diseases associated with TKTL2 include Nasopharyngitis. Among its related pathways are Carbon metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor and transketolase activity. An important paralog of this gene is TKTL1.

UniProtKB/Swiss-Prot for TKTL2 Gene

  • Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.

Gene Wiki entry for TKTL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TKTL2 Gene

Genomics for TKTL2 Gene

Regulatory Elements for TKTL2 Gene

Enhancers for TKTL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F163543 0.8 FANTOM5 10.7 -69.2 -69230 0.1 TMA16 TKTL2 MARCH1 NPY5R NPY1R ENSG00000273449 PIR37872
GH04F163540 0.5 ENCODE 10.7 -67.6 -67586 1.8 JUND FOS ZBTB33 MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
GH04F163535 0.4 ENCODE 10.7 -62.4 -62371 1.0 CTCF MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
GH04F163544 0.7 Ensembl ENCODE 10.6 -71.0 -71026 1.4 CTCF ZNF654 ZFP37 TRIM22 REST RAD21 FOXK2 MBD1 ZNF143 SMC3 MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
GH04F163549 1.7 FANTOM5 Ensembl ENCODE 10.6 -76.4 -76407 1.0 GTF2F1 CTCF CBX3 USF1 TBL1XR1 MAX ZNF384 RAD21 ZNF143 SMC3 MARCH1 TMA16 TKTL2 ENSG00000273449 PIR37872
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TKTL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TKTL2 Gene

Chromosome:
4
Start:
163,471,093 bp from pter
End:
163,473,895 bp from pter
Size:
2,803 bases
Orientation:
Minus strand

Genomic View for TKTL2 Gene

Genes around TKTL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TKTL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TKTL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TKTL2 Gene

Proteins for TKTL2 Gene

  • Protein details for TKTL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0I9-TKTL2_HUMAN
    Recommended name:
    Transketolase-like protein 2
    Protein Accession:
    Q9H0I9
    Secondary Accessions:
    • A4FVB4
    • Q8NCT0
    • Q96M82

    Protein attributes for TKTL2 Gene

    Size:
    626 amino acids
    Molecular mass:
    67877 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Cofactor:
    Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
    Quaternary structure:
    • Homodimer.

neXtProt entry for TKTL2 Gene

Selected DME Specific Peptides for TKTL2 Gene

Q9H0I9:
  • FAAFFTRAFDQ
  • ACGMAYTGKY
  • GLALAKLG
  • EDAENWHGKP
  • FTIKPLD
  • DVATGSLGQGLG
  • VIGAGVTLHEAL
  • DKASYRV
  • VLFFHTM
  • SEGSVWEA
  • MALEDLAMFR
  • GGIGEAV
  • GHAAPILYA
  • TSCCSAAE
  • ASYRVFCL
  • GSHCGVS

Post-translational modifications for TKTL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TKTL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TKTL2 Gene

Suggested Antigen Peptide Sequences for TKTL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0I9

UniProtKB/Swiss-Prot:

TKTL2_HUMAN :
  • Belongs to the transketolase family.
Family:
  • Belongs to the transketolase family.
genes like me logo Genes that share domains with TKTL2: view

No data available for Gene Families for TKTL2 Gene

Function for TKTL2 Gene

Molecular function for TKTL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
UniProtKB/Swiss-Prot Function:
Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis.

Enzyme Numbers (IUBMB) for TKTL2 Gene

Gene Ontology (GO) - Molecular Function for TKTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004802 transketolase activity IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TKTL2: view
genes like me logo Genes that share phenotypes with TKTL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TKTL2

miRNA for TKTL2 Gene

miRTarBase miRNAs that target TKTL2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TKTL2 Gene

Localization for TKTL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TKTL2 Gene COMPARTMENTS Subcellular localization image for TKTL2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TKTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TKTL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TKTL2 Gene

Pathways & Interactions for TKTL2 Gene

genes like me logo Genes that share pathways with TKTL2: view

Pathways by source for TKTL2 Gene

Gene Ontology (GO) - Biological Process for TKTL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TKTL2: view

No data available for SIGNOR curated interactions for TKTL2 Gene

Drugs & Compounds for TKTL2 Gene

(4) Drugs for TKTL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glyceraldehyde-3-Phosphate Experimental Pharma 0
thiamin diphosphate Experimental Pharma 0
calcium Nutra 0
Magnesium Nutra 0

(9) Additional Compounds for TKTL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aminofructose 6-phosphate
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
  • D-Erythrose 4-PO4
  • D-Erythrose-4-P
  • D-Erythrose-4-phosphate
  • Erythrose 4-phosphate
585-18-2
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
  • D-Ribose-5-P
  • D-Ribose-5-phosphate
  • D-Ribose-5-phosphorate
  • D-Ribose-5-phosphoric acid
3615-55-2
D-Ribulose 5-phosphate
  • alpha-D-Ribose 5-phosphate
  • D-Ribulose 5-phosphate
  • Erythro-Pentulose 5-phosphate
  • Ribulose 5-phosphate
  • Ribulose phosphate
4151-19-3
genes like me logo Genes that share compounds with TKTL2: view

Transcripts for TKTL2 Gene

mRNA/cDNA for TKTL2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(54) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TKTL2 Gene

Transketolase-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TKTL2 Gene

No ASD Table

Relevant External Links for TKTL2 Gene

GeneLoc Exon Structure for
TKTL2
ECgene alternative splicing isoforms for
TKTL2

Expression for TKTL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TKTL2 Gene

mRNA differential expression in normal tissues according to GTEx for TKTL2 Gene

This gene is overexpressed in Testis (x49.8).

Protein differential expression in normal tissues from HIPED for TKTL2 Gene

This gene is overexpressed in Testis (45.6) and Ovary (23.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TKTL2 Gene



Protein tissue co-expression partners for TKTL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TKTL2 Gene:

TKTL2

SOURCE GeneReport for Unigene cluster for TKTL2 Gene:

Hs.303923

mRNA Expression by UniProt/SwissProt for TKTL2 Gene:

Q9H0I9-TKTL2_HUMAN
Tissue specificity: Overexpressed in hepatoma cancer cells.
genes like me logo Genes that share expression patterns with TKTL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TKTL2 Gene

Orthologs for TKTL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TKTL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TKTL2 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia TKTL2 34 35
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Tktl2 34 16 35
  • 80.91 (n)
rat
(Rattus norvegicus)
Mammalia Tktl2 34
  • 80.59 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tktl2 34
  • 71.09 (n)
MGC76292 34
African clawed frog
(Xenopus laevis)
Amphibia MGC69114 34
zebrafish
(Danio rerio)
Actinopterygii tktb 34 35
  • 68.61 (n)
tkt 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10494 34
fruit fly
(Drosophila melanogaster)
Insecta CG8036 34 35
  • 59.79 (n)
CG5103 35
  • 51 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011161 34
  • 58.13 (n)
worm
(Caenorhabditis elegans)
Secernentea tkt-1 34 35
  • 60.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TKL1 35
  • 23 (a)
ManyToMany
TKL2 35
  • 21 (a)
ManyToMany
Species where no ortholog for TKTL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TKTL2 Gene

ENSEMBL:
Gene Tree for TKTL2 (if available)
TreeFam:
Gene Tree for TKTL2 (if available)

Paralogs for TKTL2 Gene

Paralogs for TKTL2 Gene

(3) SIMAP similar genes for TKTL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TKTL2: view

Variants for TKTL2 Gene

Sequence variations from dbSNP and Humsavar for TKTL2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10004056 -- 163,475,089(+) CATTG(A/G)ACTCT upstream-variant-2KB
rs112055389 -- 163,473,464(+) GTCAC(C/G)CACCT reference, missense
rs113691794 -- 163,473,169(+) TTTGT(A/C)CCAAG reference, missense
rs114528363 -- 163,474,607(+) TCACC(C/T)TATAA upstream-variant-2KB
rs114595291 -- 163,473,181(+) GGTTC(A/G)CGTCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TKTL2 Gene

Variant ID Type Subtype PubMed ID
nsv1015505 CNV gain 25217958
nsv1028437 CNV gain 25217958
nsv1030184 CNV loss 25217958

Variation tolerance for TKTL2 Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TKTL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TKTL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TKTL2 Gene

Disorders for TKTL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TKTL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nasopharyngitis
  • chronic nasopharyngitis
- elite association - COSMIC cancer census association via MalaCards
Search TKTL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TKTL2

Genetic Association Database (GAD)
TKTL2
Human Genome Epidemiology (HuGE) Navigator
TKTL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TKTL2
genes like me logo Genes that share disorders with TKTL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TKTL2 Gene

Publications for TKTL2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  3. Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. (PMID: 17321041) Zhang S. … Cai P.-C. (Cancer Lett. 2007) 4 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for TKTL2 Gene

Sources for TKTL2 Gene

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