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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TKTL1 Gene

protein-coding   GIFtS: 59
GCID: GC0XP153524

transketolase-like 1
 Explore 34 diseases affiliated with
TKTL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TKTL1    

Aliases
for TKTL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transketolase-Like 11 2     EC 2.2.1.13 8
TKR1 2 3 5     Transketolase-21
TKT21 2 3 5     Transketolase-Like Protein 12
Transketolase-Related Protein2 3     Transketolase 23
TK 22 3     

External Ids:    HGNC: 118351   Entrez Gene: 82772   Ensembl: ENSG000000073507   OMIM: 3000445   UniProtKB: P518543   

Export aliases for TKTL1 gene to outside databases

Previous GC identifers: GC0XP147587 GC0XP149914 GC0XP151109 GC0XP152001 GC0XP151992 GC0XP153044 GC0XP153178 GC0XP142101


Summaries
for TKTL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TKTL1:
The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of
sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This
reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of
Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: TKTL1_HUMAN, P51854
Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent
intermediate with the cofactor thiamine pyrophosphate (By similarity)

Gene Wiki entry for TKTL1


Genomic Views
for TKTL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_167198.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TKTL1 gene promoter:
         HFH-3   AhR   Lmo2   MIF-1   Arnt   MZF-1   FOXI1   FOXJ2 (long isoform)   Cart-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TKTL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TKTL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TKTL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

TKTL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TKTL1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153524:  view genomic region     (about GC identifiers)

Start:
 153,524,024 bp from pter      End:
 153,558,713 bp from pter
Size:
 34,690 bases      Orientation:
 plus strand

Proteins
for TKTL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TKTL1_HUMAN, P51854 (See protein sequence)
Recommended Name: Transketolase-like protein 1  
Size: 596 amino acids; 65333 Da
Cofactor: Binds 1 magnesium ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and
Co(2+) (By similarity)
Cofactor: Binds 1 thiamine pyrophosphate per subunit (By similarity)
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic and to a lesser extent also nuclear
Miscellaneous: Strong TKTL1 protein expression has been correlated with a certain type of glucose metabolism (aerobic
glycolysis; Warburg effect) and to cells which are affected by chronic complications of diabetic patients
Secondary accessions: A8K896 Q5TYJ9 Q8TC75
Alternative splicing: 3 isoforms:  P51854-3   P51854-1   P51854-2   (Lacks the N-terminal)

Explore the universe of human proteins at neXtProt for TKTL1: NX_P51854

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51854

    • 4/9 DME Specific Peptides for TKTL1 (P51854) (see all 9)
     GGIGEAV  LDNLVAI  GSHCGVS  FTIKPLD 

    TKTL1 Protein expression data from MOPED and PaxDb:    About this image 
    TKTL1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001139405.1  NP_001139406.1  NP_036385.3  

    ENSEMBL proteins: 
     ENSP00000358931   ENSP00000399763   ENSP00000401111   ENSP00000416552   ENSP00000358928  
     ENSP00000217905  

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    Uscn Proteins for TKTL1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    TKTL1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TKTL1

    Protein Domains /
    Families
    for TKTL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TKTL1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR005474 Transketolase_N
     IPR005476 Transketolase_C
     IPR009014 Transketo_C/Pyr-ferredox_oxred
     IPR005475 Transketolase-like_Pyr-bd
     IPR020826 Transketolase_BS

    Graphical View of Domain Structure for InterPro Entry P51854

    ProtoNet protein and cluster: P51854

    2 Blocks protein families:
    IPB005475 Transketolase
    IPB005476 Transketolase


    UniProtKB/Swiss-Prot: TKTL1_HUMAN, P51854
    Similarity: Belongs to the transketolase family


    Function
    for TKTL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TKTL1_HUMAN, P51854
    Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent
    intermediate with the cofactor thiamine pyrophosphate (By similarity)
    Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose
    5-phosphate

         Genatlas biochemistry entry for TKTL1:
    transketolase-related

         Enzyme Number (IUBMB): EC 2.2.1.11 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004802transketolase activity IEA--
    GO:0046872metal ion binding IEA--
         
    TKTL1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tktl1):
     digestive/alimentary  growth/size  immune system 

    TKTL1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Tktl1tm1Arte for TKTL1
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    miRNA
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    Inhib. RNA
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    In Situ Assay
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    Pathways & Interactions
    for TKTL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pentose phosphate pathway (hexose monophosphate shunt)
    		pentose phosphate pathway0.67
    		pentose phosphate pathway (non-oxidative branch)0.33
    2Pentose phosphate pathway
    		Pentose phosphate pathway1.00
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for TKTL1 
        pentose phosphate pathway
    pentose phosphate pathway (non-oxidative branch)


    2         Kegg Pathways  (Kegg details for TKTL1):
        Pentose phosphate pathway
    Metabolic pathways


    TKTL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TKTL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for TKTL1 (ENSP000003589314) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALDOCENSP000002262534STRING: ENSP00000226253
    FBP1ENSP000003644754STRING: ENSP00000364475
    GPIENSP000003488774STRING: ENSP00000348877
    PFKMENSP000003528424STRING: ENSP00000352842
    PGM2ENSP000003713934STRING: ENSP00000371393
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006007glucose catabolic process TAS8838793
    GO:0006772thiamine metabolic process TAS8838793

    TKTL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TKTL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TKTL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TKTL1

    10 HMDB Compounds for TKTL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    CalciumCa (see all 2)7440-70-2--
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Ribose 5-phosphateD-Ribose 5-phosphate (see all 11)3615-55-2--
    D-Ribulose 5-phosphateD-Ribulose 5-phosphate (see all 5)4151-19-3--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    MagnesiumMagnesium (see all 2)7439-95-4--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--
    Thiamine pyrophosphateTPP (see all 11)154-87-0--
    Xylulose 5-phosphateD-xylulose-5-P (see all 9)4212-65-1--
    1 Novoseek chemical compound relationship for TKTL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 45.4 10 18806930 (2), 18394773 (1), 19065656 (1), 18302154 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TKTL1 

    Transcripts
    for TKTL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TKTL1 gene (3 alternative transcripts): 
    NM_001145933.1  NM_001145934.1  NM_012253.3  

    Unigene Cluster for TKTL1:

    Transketolase-like 1
    Hs.102866  [show with all ESTs]
    Unigene Representative Sequence: NM_012253
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369915(uc011mzl.2 uc004fkg.3 uc011mzm.2) ENST00000439635
    ENST00000426989 ENST00000426203 ENST00000369912(uc004fkh.3) ENST00000465168
    ENST00000482044 ENST00000463884 ENST00000217905

    miRNA
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    hsa-miR-1205
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK292224.1 AK292261.1 AK301724.1 AK302044.1 AK302261.1 BC025382.2 X91817.1 X91818.1 

    8 DOTS entries:

    DT.205641  DT.75106987  DT.121294785  DT.121294717  DT.40289061  DT.121294014  DT.121294396  DT.97812633 

    24/61 AceView cDNA sequences (see all 61):

    BX112280 X91817 AW002472 AI671869 AW193779 NM_012253 X91818 BX646229 
    CD359239 AW341491 AI743615 AI638101 CD359640 BG717394 BG208656 AW451064 
    AI027295 BM698785 AL703992 AL704899 BC025382 BG719396 CB108588 CD359574 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TKTL1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15
    SP1:                                                                                      -                             -                           
    SP2:        -     -     -     -                                                                                                                     
    SP3:                    -     -                                                                                                                     
    SP4:                          -                                                                                                                     
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for TKTL1

    Expression
    for TKTL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TKTL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACGCCTACTG
    TKTL1 Expression
    About this image

    TKTL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)Bone, Cartilage, Limb
    Epiblast-like cells (Reconstitution of mo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TKTL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TKTL1

    SOURCE GeneReport for Unigene cluster: Hs.102866

    UniProtKB/Swiss-Prot: TKTL1_HUMAN, P51854
    Tissue specificity: Expressed in fetal and adult heart, brain, lung, liver, and kidney, and in adult placenta, skeletal
    muscle and pancreas. Up-regulated in various epithelial tumors

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    In Situ
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    Orthologs
    for TKTL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for TKTL1 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 64(a)
    		 1 → many
    		 2(88688852-88701278)
    zebrafish
    (Danio rerio)    		 Actinopterygii tkt6
    		 transketolase
    		 60(a)
    		 possible ortholog
    		 23(20401928-20414807)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG80363 transketolase 54(a)   85A5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea tkt-16
    		 --
    		 51(a)
    		 1 → many
    		 IV(10243569-10245730)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons DXPS16
    DXPS36
    (see all 3)    		 1-deoxy-D-xylulose 5-phosphate synthase 3
    (see all 3)    		 18(a)
    15(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 3(7573634-7576623)
    5(3629998-3633441)
    rice
    (Oryza sativa)    		 Liliopsida DXS36
    DXS16
    (see all 3)    		 transketolase, putative, expressed
    (see all 3)    		 16(a)
    16(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 7(4820208-4823668)
    5(19894615-19900596)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria dxs6
    		 1-deoxyxylulose-5-phosphate synthase, thiamine-req...
    		 18(a)
    		 possible ortholog
    		 Chromosome(437539-439401)


    ENSEMBL Gene Tree for TKTL1 (if available)
    TreeFam Gene Tree for TKTL1 (if available) 

    Paralogs
    for TKTL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TKTL1 gene
    TKTL22  TKT2  
    4 SIMAP similar genes for TKTL1 using alignment to 7 protein entries:     TKTL1_HUMAN (see all proteins):
    DKFZp434B129    DKFZp686J13123    TKTL2    TKT

    TKTL1 for paralogs           About GeneDecksing



    Genomic Variants
    for TKTL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/530 NCBI SNPs in TKTL1 are shown (see all 530)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2012414921,2
    		--153525594(+) CTACA-/GGTTTT 2 -- int10--------
    rs1136413041,2
    		--153525595(+) TACAGG/TTTTTT 2 -- int10--------
    rs1426467891,2
    		C--153525595(+) ACAGG-/TTTTTT 2 -- int10--------
    rs1129108911,2
    		--153526180(+) GCTACG/TCGGGG 2 -- int10--------
    rs1921035131,2
    		--153526214(+) ATTGTA/GCCACT 2 -- int10--------
    rs1850320941,2
    		--153526265(+) AAAAAA/TTTTTT 2 -- int10--------
    rs1468484561,2
    		--153526343(+) GCTTTC/TATTTA 2 -- int10--------
    rs1889523431,2
    		--153526368(+) TATTAC/TTGCTT 2 -- int10--------
    rs1923935291,2
    		--153526705(+) CTGGAA/GCTACA 2 -- int10--------
    rs765759271,2
    		C--153527057(+) AAAAAA/TAAATT 2 -- int10--------

    HapMap Linkage Disequilibrium report for TKTL1 (153524024 - 153558713 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TKTL1
         1 CNV: 37014
         2 Inversions: 37364 37363

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TKTL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TKTL1 for disorders           About GeneDecksing

    OMIM gene information: 300044    OMIM disorders: --

    20/34 diseases for TKTL1 (see all 34):    About MalaCards
    wernicke-korsakoff syndrome    cancer progression/metastasis    granulosa cell tumor of the ovary    laryngeal squamous cell carcinoma
    hypochondroplasia    pulmonary embolism    squamous cell carcinoma    papillary thyroid carcinoma
    achondroplasia    adrenocortical carcinoma    dwarfism    nephroblastoma
    thyroid carcinoma    laryngitis    neurodegenerative disease    thyroiditis
    adenoiditis    endometrial cancer    carcinoma    colon cancer

    1 disease from the University of Copenhagen DISEASES database for TKTL1:
    Nasopharyngitis

    3 Novoseek disease relationships for TKTL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 41.7 13 19159596 (3), 17291239 (1), 18615628 (1)
    cancer 38.6 7 19065656 (2), 19290028 (1), 19812737 (1), 19465749 (1) (see all 5)
    tumors 36.2 30 18550470 (3), 19065656 (2), 18686341 (2), 18302154 (2) (see all 7)


    Export disorders for TKTL1 gene to outside databases

    Publications
    for TKTL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TKTL1 gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with TKTL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of tissue-specific transcripts of a transketolase- related gene: implications for the evolution of new vertebrate genes. (PubMed id 8838793)1, 2, 3, 9 Coy J.F....Poustka A. (1996)
    2. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. (PubMed id 15991799)1, 2, 9 Coy J.F.... Schubert P. (2005)
    3. Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. (PubMed id 16969476)1, 2 Staiger W.I.... Willeke F. (2006)
    4. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. (PubMed id 16465194)1, 2 Langbein S....Coy J.F. (2006)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression of Transketolase-like 1 and Activation of Akt in Grade IV Glioblastomas Compared With Grades II and III Astrocytic Gliomas. (PubMed id 18550470)1, 9 Volker H.U....Monoranu C.M. (2008)
    8. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. (PubMed id 19065656)1, 9 Xu X....LAPchelt M. (2009)
    9. Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia. (PubMed id 18686341)1, 9 Kohrenhagen N....Kammerer U. (2008)
    10. Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. (PubMed id 20385008)1, 9 Kayser G....zur Hausen A. (2010)

    External Searches for TKTL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TKTL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8277 HGNC: 11835 AceView: TKTL1 Ensembl:ENSG00000007350 euGenes: HUgn8277
    ECgene: TKTL1 Kegg: 8277 H-InvDB: TKTL1

    Other Databases showing TKTL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TKTL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TKTL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TKTL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TKTL1 gene:
    Search GeneIP for patents involving TKTL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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