Aliases for TKT Gene
External Ids for TKT Gene
Previous GeneCards Identifiers for TKT Gene
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for TKT Gene
TKT (Transketolase) is a Protein Coding gene. Diseases associated with TKT include Short Stature, Developmental Delay, And Congenital Heart Defects and Transketolase Deficiency. Among its related pathways are Metabolism and Pentose phosphate pathway. GO annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor. An important paralog of this gene is TKTL2.
UniProtKB/Swiss-Prot for TKT Gene
Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.