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Aliases for TKT Gene

Aliases for TKT Gene

  • Transketolase 2 3
  • EC 2.2.1.1 4 63
  • TK 3 4
  • Epididymis Luminal Protein 107 3
  • Wernicke-Korsakoff Syndrome 2
  • HEL107 3
  • TKT1 3

External Ids for TKT Gene

Previous GeneCards Identifiers for TKT Gene

  • GC03M052351
  • GC03M052511
  • GC03M053114
  • GC03M053217
  • GC03M053233

Summaries for TKT Gene

Entrez Gene Summary for TKT Gene

  • This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for TKT Gene

TKT (Transketolase) is a Protein Coding gene. Diseases associated with TKT include spondylometaepiphyseal dysplasia, short limb-hand type and beriberi. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include protein homodimerization activity and transketolase activity. An important paralog of this gene is TKTL2.

UniProtKB/Swiss-Prot for TKT Gene

  • Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TKT Gene

Genomics for TKT Gene

Regulatory Elements for TKT Gene

Genomic Location for TKT Gene

Start:
53,224,707 bp from pter
End:
53,256,114 bp from pter
Size:
31,408 bases
Orientation:
Minus strand

Genomic View for TKT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TKT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TKT Gene

Proteins for TKT Gene

  • Protein details for TKT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29401-TKT_HUMAN
    Recommended name:
    Transketolase
    Protein Accession:
    P29401
    Secondary Accessions:
    • A8K089
    • B4DE31
    • E7EPA7
    • Q8TBA3
    • Q96HH3

    Protein attributes for TKT Gene

    Size:
    623 amino acids
    Molecular mass:
    67878 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).;
    Cofactor:
    Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Note=Binds 1 thiamine pyrophosphate per subunit.;
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for TKT Gene

    Alternative splice isoforms for TKT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TKT Gene

Proteomics data for TKT Gene at MOPED

Post-translational modifications for TKT Gene

  • Ubiquitination at Lys16, Lys114, Lys140, Lys204, Lys232, Lys241, Lys254, Lys283, Lys310, Lys319, Lys456, Lys465, Lys499, and Lys538
  • Modification sites at PhosphoSitePlus

Other Protein References for TKT Gene

Domains for TKT Gene

Graphical View of Domain Structure for InterPro Entry

P29401

UniProtKB/Swiss-Prot:

TKT_HUMAN :
  • P29401
Family:
  • Belongs to the transketolase family.
genes like me logo Genes that share domains with TKT: view

No data available for Gene Families for TKT Gene

Function for TKT Gene

Molecular function for TKT Gene

GENATLAS Biochemistry: transketolase,pentose phosphate pathway
UniProtKB/Swiss-Prot CatalyticActivity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
UniProtKB/Swiss-Prot Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate

Enzyme Numbers (IUBMB) for TKT Gene

Gene Ontology (GO) - Molecular Function for TKT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004802 transketolase activity IDA 20667822
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor --
GO:0042803 protein homodimerization activity IDA 20667822
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TKT: view
genes like me logo Genes that share phenotypes with TKT: view

Animal Models for TKT Gene

MGI Knock Outs for TKT:

No data available for Transcription Factor Targeting and HOMER Transcription for TKT Gene

Localization for TKT Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TKT Gene COMPARTMENTS Subcellular localization image for TKT gene
Compartment Confidence
cytosol 4
nucleus 4
peroxisome 4
chloroplast 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TKT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005777 peroxisome ISS --
GO:0005829 cytosol TAS --
GO:0031982 vesicle IDA 19190083
genes like me logo Genes that share ontologies with TKT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TKT Gene

Pathways for TKT Gene

genes like me logo Genes that share pathways with TKT: view

Gene Ontology (GO) - Biological Process for TKT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005999 xylulose biosynthetic process TAS --
GO:0006098 pentose-phosphate shunt TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with TKT: view

Compounds for TKT Gene

(13) HMDB Compounds for TKT Gene

Compound Synonyms Cas Number PubMed IDs
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Not Available
Calcium
  • Ca
7440-70-2
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
585-18-2
D-Glyceraldehyde 3-phosphate
  • 2-hydroxy-3-(phosphonooxy)-Propanal
142-10-9
D-Ribose 5-phosphate
  • D-Ribose 5-phosphate
3615-55-2

(152) Novoseek inferred chemical compound relationships for TKT Gene

Compound -log(P) Hits PubMed IDs
thymidine 93.6 126
ganciclovir 87.7 116
thiamine pyrophosphate 84.2 34
thiamine 80.3 72
benfotiamine 79.3 9
genes like me logo Genes that share compounds with TKT: view

Transcripts for TKT Gene

Unigene Clusters for TKT Gene

Transketolase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TKT Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - -
SP7: -
SP8: -
SP9: - - -
SP10: - - -
SP11:
SP12: - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - -
SP15:

ExUns: 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15:

Relevant External Links for TKT Gene

GeneLoc Exon Structure for
TKT
ECgene alternative splicing isoforms for
TKT

Expression for TKT Gene

mRNA expression in normal human tissues for TKT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TKT Gene

This gene is overexpressed in Whole Blood (11.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TKT Gene

SOURCE GeneReport for Unigene cluster for TKT Gene Hs.89643

genes like me logo Genes that share expressions with TKT: view

No data available for mRNA Expression by UniProt/SwissProt for TKT Gene

Orthologs for TKT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TKT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TKT 35
  • 99.2 (n)
  • 99.36 (a)
TKT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TKT 35
  • 89.73 (n)
  • 93.58 (a)
TKT 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TKT 35
  • 88.18 (n)
  • 91.1 (a)
TKT 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tkt 35
  • 87.35 (n)
  • 94.86 (a)
Tkt 16
Tkt 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TKT 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TKT 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tkt 35
  • 88 (n)
  • 94.21 (a)
chicken
(Gallus gallus)
Aves TKT 35
  • 74.54 (n)
  • 84.31 (a)
TKT 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TKT 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68785 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tkt 35
  • 74.16 (n)
  • 78.65 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557518 35
  • 70.84 (n)
  • 70.68 (a)
TKT 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5103 36
  • 54 (a)
ManyToMany
CG8036 36
  • 59 (a)
ManyToMany
CG5103 37
  • 54 (a)
CG8036 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea tkt-1 36
  • 60 (a)
OneToMany
F01G10.1 37
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TKL1 36
  • 24 (a)
ManyToMany
TKL1 38
TKL2 36
  • 22 (a)
ManyToMany
Species with no ortholog for TKT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TKT Gene

ENSEMBL:
Gene Tree for TKT (if available)
TreeFam:
Gene Tree for TKT (if available)

Paralogs for TKT Gene

Paralogs for TKT Gene

Selected SIMAP similar genes for TKT Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TKT: view

Variants for TKT Gene

Sequence variations from dbSNP and Humsavar for TKT Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3162 -- 53,225,827(+) CAGCA(C/G)CTCAG reference, missense, nc-transcript-variant, utr-variant-3-prime
rs3163 -- 53,225,834(-) AAGCC(A/G)GCTGA synonymous-codon, reference, nc-transcript-variant, utr-variant-3-prime
rs728910 -- 53,231,941(+) CTCAG(C/T)TTGTC intron-variant
rs735940 -- 53,232,515(-) TGCCC(A/G)GGGAC intron-variant
rs900494 -- 53,232,373(+) AGAAC(A/G)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TKT Gene

Variant ID Type Subtype PubMed ID
nsv834699 CNV Loss 17160897
nsv517233 CNV Loss 19592680
esv1009267 CNV Insertion 20482838
esv1068681 CNV Insertion 17803354
nsv3824 CNV Loss 18451855

Relevant External Links for TKT Gene

HapMap Linkage Disequilibrium report
TKT
Human Gene Mutation Database (HGMD)
TKT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TKT Gene

Disorders for TKT Gene

(3) University of Copenhagen DISEASES for TKT Gene

(92) Novoseek inferred disease relationships for TKT Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 85.1 103
thiamine deficiency 75.6 15
korsakoff syndrome 70.3 10
tumors 57.3 154
thyroid papillary carcinoma 53.4 7

Relevant External Links for TKT

Genetic Association Database (GAD)
TKT
genes like me logo Genes that share disorders with TKT: view

No data available for UniProtKB/Swiss-Prot for TKT Gene

Publications for TKT Gene

  1. Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase. (PMID: 1567394) Abedinia M. … Mattick J.S. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke- Korsakoff individuals. (PMID: 8419340) McCool B.A. … Singleton C.K. (J. Biol. Chem. 1993) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  5. Transketolase is a major protein in the mouse cornea. (PMID: 8969223) Sax C.M. … Piatigorsky J. (J. Biol. Chem. 1996) 3 23

Products for TKT Gene

  • Addgene plasmids for TKT

Sources for TKT Gene

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