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TKT Gene

protein-coding   GIFtS: 68
GCID: GC03M053258

Transketolase

  See TKT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
transketolase1 2     HEL1072
TK2 3     TKT12
EC 2.2.1.13 8     Epididymis Luminal Protein 1072
Wernicke-Korsakoff Syndrome1     

External Ids:    HGNC: 118341   Entrez Gene: 70862   Ensembl: ENSG000001639317   OMIM: 6067815   UniProtKB: P294013   

Export aliases for TKT gene to outside databases

Previous GC identifers: GC03M052351 GC03M052511 GC03M053114 GC03M053217 GC03M053233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TKT Gene:
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to
glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms
have been observed for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for TKT Gene:
TKT (transketolase) is a protein-coding gene. Diseases associated with TKT include beriberi, and spondylometaepiphyseal dysplasia short limb-hand type. GO annotations related to this gene include protein homodimerization activity and transketolase activity. An important paralog of this gene is TKTL2.

UniProtKB/Swiss-Prot: TKT_HUMAN, P29401
Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a
covalent intermediate with the cofactor thiamine pyrophosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TKT gene promoter:
         NF-1   Sp1   p53   HFH-1   LUN-1   Egr-4   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTKT promoter sequence
   Search Chromatin IP Primers for TKT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TKT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p14.3

TKT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TKT gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M053258:  view genomic region     (about GC identifiers)

Start:
53,258,723 bp from pter      End:
53,290,130 bp from pter
Size:
31,408 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TKT_HUMAN, P29401 (See protein sequence)
Recommended Name: Transketolase  
Size: 623 amino acids; 67878 Da
Cofactor: Binds 1 magnesium ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+)
and Co(2+)
Cofactor: Binds 1 thiamine pyrophosphate per subunit
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for TKT (see all 7):
3MOS (3D)        3OOY (3D)        4KXU (3D)        4KXV (3D)        4KXW (3D)        4KXX (3D)    
Secondary accessions: A8K089 B4DE31 E7EPA7 Q8TBA3 Q96HH3
Alternative splicing: 2 isoforms:  P29401-1   P29401-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TKT: NX_P29401

Explore proteomics data for TKT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys16, Lys114, Lys140, Lys204, Lys232, Lys241, Lys254, Lys283, Lys310, Lys319,
                                 Lys456, Lys465, Lys499, Lys538
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TKT (P29401) (see all 29)
     GGIGEAV  LDNLVAI  GSHCGVS  DKASYRV 


    See TKT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001055.1  NP_001128527.1  NP_001244957.1  

    ENSEMBL proteins: 
     ENSP00000417773   ENSP00000405455   ENSP00000413503   ENSP00000391481   ENSP00000418340  
     ENSP00000417312   ENSP00000296289  
    Reactome Protein details: P29401

    TKT Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for TKT
    OriGene Protein Over-expression Lysate for TKT
    OriGene MassSpec for TKT
    OriGene Custom Protein Services for TKT
    GenScript Custom Purified and Recombinant Proteins Services for TKT
    Novus Biologicals TKT Proteins
    Novus Biologicals TKT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TKT
    Cloud-Clone Corp. Proteins for TKT

     
    Search eBioscience for Proteins for TKT 

     
    antibodies-online proteins for TKT (6 products) 

     
    antibodies-online peptides for TKT

    TKT Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cell Signaling Technology (CST) Antibodies for TKT 
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    Novus Biologicals TKT Antibodies
    Abcam antibodies for TKT
    Cloud-Clone Corp. Antibodies for TKT
    ThermoFisher Antibodies for TKT
    LSBio Antibodies in human, mouse, rat for TKT
    antibodies-online antibodies for TKT (23 products) 

    TKT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TKT
    Cloud-Clone Corp. CLIAs for TKT
    Search eBioscience for ELISAs for TKT 
    antibodies-online kits for TKT (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR005474 Transketolase_N
     IPR005476 Transketolase_C
     IPR009014 Transketo_C/Pyr-ferredox_oxred
     IPR005475 Transketolase-like_Pyr-bd
     IPR020826 Transketolase_BS

    Graphical View of Domain Structure for InterPro Entry P29401

    ProtoNet protein and cluster: P29401

    2 Blocks protein domains:
    IPB005475 Transketolase
    IPB005476 Transketolase


    UniProtKB/Swiss-Prot: TKT_HUMAN, P29401
    Similarity: Belongs to the transketolase family


    Find genes that share domains with TKT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TKT_HUMAN, P29401
    Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a
    covalent intermediate with the cofactor thiamine pyrophosphate
    Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose
    5-phosphate

         Genatlas biochemistry entry for TKT:
    transketolase,pentose phosphate pathway

         Enzyme Number (IUBMB): EC 2.2.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004802transketolase activity IDA--
    GO:0016624oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor ----
    GO:0042803protein homodimerization activity IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TKT           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TKT:
     Increased HPV18 LCR reporter a 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tkt):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size/body 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  reproductive system 
     vision/eye 

    Find genes that share phenotypes with TKT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tkttm1Jpi for TKT

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TKT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TKT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TKT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TKT

    miRNA
    Products:
        
    miRTarBase miRNAs that target TKT:
    hsa-mir-106b-3p (MIRT038566), hsa-mir-1 (MIRT024031), hsa-mir-92a-3p (MIRT049252), hsa-mir-484 (MIRT041785), hsa-mir-331-3p (MIRT043397), hsa-mir-149-5p (MIRT045530), hsa-mir-30c-5p (MIRT047913), hsa-mir-26a-5p (MIRT050103)

    Block miRNA regulation of human, mouse, rat TKT using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate TKT:
    hsa-miR-1323 hsa-miR-616* hsa-miR-514b-5p hsa-miR-513c hsa-miR-548o hsa-miR-371-5p hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TKT
    Predesigned siRNA for gene silencing in human, mouse, rat TKT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TKT

    Clone
    Products:
         
    OriGene clones in human, mouse for TKT (see all 13)
    OriGene ORF clones in mouse, rat for TKT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TKT (NM_001064)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TKT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKT
    Addgene plasmids for TKT 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TKT
    Browse ESI BIO Cell Lines and PureStem Progenitors for TKT 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    peroxisome4
    chloroplast2
    mitochondrion2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005777peroxisome ISS--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with TKT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TKT About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Pentose Phosphate Pathway (WikiPathways)
    Pentose Phosphate Pathway
    Insulin effects increased synthesis of Xylulose-5-Phosphate0.00
    Pentose phosphate pathway (hexose monophosphate shunt)0.00
    2Pentose phosphate pathway (KEGG)
    pentose phosphate pathway (non-oxidative branch)0.00
    pentose phosphate pathway0.00
    Pentose phosphate pathway
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Carbon metabolism
    Carbon metabolism0.38
    Biosynthesis of amino acids0.38
    5Integration of energy metabolism
    Integration of energy metabolism0.75


    Find genes that share SuperPaths with TKT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TKT
        Glucose / Energy Metabolism

    3 BioSystems Pathways for TKT
        pentose phosphate pathway
    Pentose Phosphate Pathway
    pentose phosphate pathway (non-oxidative branch)

    2 Reactome Pathways for TKT
        Pentose phosphate pathway (hexose monophosphate shunt)
    Insulin effects increased synthesis of Xylulose-5-Phosphate


    4 Kegg Pathways  (Kegg details for TKT):
        Pentose phosphate pathway
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids

        Pathway & Disease-focused RT2 Profiler PCR Array including TKT: 
              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TKT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TKT (P294012, 3 ENSP000004054554) via UniProtKB, MINT, STRING, and/or I2D (see all 157)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3304676 I2D: score=2 STRING: ENSP00000309503
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    CTHP329293, ENSP000003599764I2D: score=1 STRING: ENSP00000359976
    G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
    GABARAPL2P605203, ENSP000000372434I2D: score=1 STRING: ENSP00000037243
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005999xylulose biosynthetic process TAS--
    GO:0006098pentose-phosphate shunt TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0008152metabolic process ----

    Find genes that share ontologies with TKT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TKT

    Selected HMDB Compounds for TKT (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    CalciumCa (see all 2)7440-70-2--
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    D-Ribose 5-phosphateD-Ribose 5-phosphate (see all 11)3615-55-2--
    D-Ribulose 5-phosphateD-Ribulose 5-phosphate (see all 5)4151-19-3--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    Fructose 6-phosphateD-Fructose 6-phosphate (see all 13)643-13-0--
    MagnesiumMagnesium (see all 2)7439-95-4--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--

    Selected Novoseek inferred chemical compound relationships for TKT gene (see all 152)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 93.6 736 11923581 (4), 9127632 (3), 2210063 (3), 7705935 (2) (see all 99)
    ganciclovir 87.7 190 16390269 (4), 8690797 (4), 9923018 (3), 10945770 (3) (see all 89)
    thiamine pyrophosphate 84.2 93 16097940 (3), 7861245 (2), 19290028 (2), 17309441 (2) (see all 26)
    thiamine 80.3 99 9568183 (5), 7861245 (3), 11488910 (3), 9951304 (2) (see all 51)
    benfotiamine 79.3 9 16452468 (2), 16416271 (1), 12882930 (1), 18581039 (1) (see all 8)
    l-erythrulose 78.5 2 14505172 (1), 18224278 (1)
    bvdu 78.1 13 15168799 (2), 18066636 (1), 9415318 (1), 10188760 (1) (see all 5)
    acyclovir 78 100 11793392 (4), 11060773 (3), 10421406 (3), 10882609 (3) (see all 45)
    tyrosine 77.3 354 18182111 (2), 9115253 (2), 8188658 (2), 8628282 (2) (see all 99)
    bv-arau 77.2 19 15168799 (2), 8295566 (2), 8849252 (1), 18066636 (1) (see all 7)



    Find genes that share compounds with TKT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TKT gene (4 alternative transcripts): 
    NM_001064.3  NM_001135055.2  NM_001258028.1  NM_001135056.1  

    Unigene Cluster for TKT:

    Transketolase
    Hs.89643  [show with all ESTs]
    Unigene Representative Sequence: NM_001135055
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462138(uc003dgo.3 uc003dgp.2 uc011beo.1 uc003dgq.3 uc011beq.2 uc011ber.2)
    ENST00000423525 ENST00000460343 ENST00000461139 ENST00000450814 ENST00000423516
    ENST00000469678 ENST00000460243 ENST00000472528 ENST00000494523 ENST00000466765
    ENST00000487660 ENST00000483706 ENST00000296289
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate TKT:
    hsa-miR-1323 hsa-miR-616* hsa-miR-514b-5p hsa-miR-513c hsa-miR-548o hsa-miR-371-5p hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TKT
    Clone
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    OriGene clones in human, mouse for TKT (see all 13)
    OriGene ORF clones in mouse, rat for TKT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TKT (NM_001064)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TKT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKT
    Addgene plasmids for TKT 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TKT
    OriGene qSTAR qPCR primer pairs in human, mouse for TKT
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TKT
      QuantiTect SYBR Green Assays in human, mouse, rat TKT
      QuantiFast Probe-based Assays in human, mouse, rat TKT

    Additional mRNA sequence: 

    AK093667.1 AK223614.1 AK289454.1 AK293438.1 AK301231.1 AK303191.1 AK309482.1 BC002433.2 
    BC008615.1 BC009970.2 BC024026.2 BX647248.1 L12711.1 NR_047580.1 U55017.1 X67688.1 

    Selected DOTS entries (see all 61):

    DT.100889803  DT.419434  DT.100889811  DT.95146007  DT.95145910  DT.100889832  DT.100889827  DT.100889826 
    DT.91950120  DT.100889843  DT.91960759  DT.100889813  DT.100889847  DT.91999919  DT.100889819  DT.92384439 
    DT.92000149  DT.120844582  DT.202104  DT.91664093  DT.91697449  DT.100889859  DT.100889860  DT.100753730 

    Selected AceView cDNA sequences (see all 1420):

    BC024026 CR600295 BC008615 BM762119 BU177161 AA325034 BX396942 AW006207 
    AW590438 BG388023 BU662400 BQ436725 CB266872 BM450913 BU171585 AU131011 
    CB106876 AU135093 CN484492 BU627526 BP361919 BQ232899 BU682236 BQ215526 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TKT (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a ·
    SP1:                                      -                       -     -                       -     -                             -                       -   
    SP2:                                      -                       -     -                       -     -                             -                       -   
    SP3:                    -     -     -     -     -                 -     -                       -     -                             -                       -   
    SP4:                                                                                                                                -                 -         
    SP5:                                                                                                                                                        -   

    ExUns: 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                          -                             -         
    SP2:                          -                                       
    SP3:                          -                                       
    SP4:                          -                                       
    SP5:                          -                                       


    ECgene alternative splicing isoforms for TKT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TKT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCCATCT
    TKT Expression
    About this image


    TKT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Lens
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
    TKT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TKT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89643
        Pathway & Disease-focused RT2 Profiler PCR Array including TKT: 
              Glucose Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TKT gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tkt1 , 5 transketolase1, 5 87.35(n)1
    94.86(a)1
      14 (18.79 cM)5
    218811  NM_009388.51  NP_033414.11 
     305483595 
    chicken
    (Gallus gallus)
    Aves TKT1 transketolase 74.54(n)
    84.31(a)
      415991  XM_004944561.1  XP_004944618.1 
    lizard
    (Anolis carolinensis)
    Reptilia TKT6
    transketolase
    82(a)
    1 ↔ 1
    2(160044020-160085807)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687852 transketolase 76.31(n)    BC060361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5575181 transketolase-like 70.84(n)
    70.68(a)
      557518  XM_005155887.1  XP_005155944.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80363 transketolase 58(a)
    (best of 2)
      85A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea F01G10.13 transketolase 60(a)   IV(10243790-10245827)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TKL1(YPR074C)4 Transketolase, similar to Tkl2p; catalyzes conversion more   --   16(694838-692796) 856188  NP_015399.1 


    ENSEMBL Gene Tree for TKT (if available)
    TreeFam Gene Tree for TKT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TKT gene
    TKTL22  TKTL12  
    4 SIMAP similar genes for TKT using alignment to 5 protein entries:     TKT_HUMAN (see all proteins):
    DKFZp686J13123    TKTL2    DKFZp434B129    TKTL1

    Find genes that share paralogs with TKT           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TKT (see all 881)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126326711,2
    C,F,H--53190789(+) AGGCTG/ATTCCC 1 -- ds500116Minor allele frequency- A:0.03NS EA NA 1856
    rs1164167961,2
    C,F--53191044(+) CTCTGG/ACACTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1392437231,2
    --53191045(+) TCTGGC/TACTGC 1 -- ds50010--------
    rs352610101,2
    C--53191073(+) GGGGG-/GCAATT 1 -- ds50010--------
    rs1157792091,2
    F--53191147(+) CGTGTC/TCACAA 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs10560821,2
    C--53191177(-) CCTCAG/AAGCTG 1 -- ut31 ese33Minor allele frequency- A:0.00MN NA 188
    rs115405291,2
    C--53191348(+) TGTGAG/TGGCAG 1 -- ut310--------
    rs130939361,2
    C,F,H--53191378(+) CAGGTC/TGGGGC 1 -- ut31 ese38Minor allele frequency- T:0.10NS EA NA 532
    rs10560761,2
    C--53191419(-) AGCTTC/TTGATG 1 -- ut31 ese30--------
    rs1169905371,2
    F--53191460(+) CCCCAT/CTGGCA 1 -- ut311Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for TKT (53258723 - 53290130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TKT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1009267CNV Insertion20482838
    esv1068681CNV Insertion17803354
    nsv834699CNV Loss17160897
    nsv3824CNV Loss18451855
    nsv517233CNV Loss19592680

    Human Gene Mutation Database (HGMD): TKT
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TKT
    DNA2.0 Custom Variant and Variant Library Synthesis for TKT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606781    OMIM disorders: --

    17 diseases for TKT:    
    About MalaCards
    beriberi    spondylometaepiphyseal dysplasia short limb-hand type    smallpox    wernicke-korsakoff syndrome
    wernicke encephalopathy    transaldolase deficiency    keratitis    herpes zoster
    cowpox    thoracic cancer    post-transplant lymphoproliferative disease    thanatophoric dysplasia
    herpes simplex    carcinoid syndrome    gliosarcoma    ovarian cancer
    colorectal cancer

    3 diseases from the University of Copenhagen DISEASES database for TKT:
    Wernicke-Korsakoff syndrome     Beriberi     Wernicke encephalopathy

    Find genes that share disorders with TKT           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TKT gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 85.1 168 12475412 (3), 12050148 (2), 15483667 (2), 2153540 (1) (see all 99)
    thiamine deficiency 75.6 16 7861245 (2), 8683340 (2), 8949966 (2), 8059170 (1) (see all 12)
    korsakoff syndrome 70.3 12 8445392 (2), 7596328 (1), 7861132 (1), 8279670 (1) (see all 9)
    tumors 57.3 269 1433372 (6), 10794295 (5), 11245445 (5), 7705935 (4) (see all 99)
    thyroid papillary carcinoma 53.4 8 7519046 (1), 1437145 (1), 8570194 (1), 8628282 (1) (see all 7)
    myeloid leukemia chronic 51.1 12 19536317 (1), 2304355 (1), 19643477 (1), 12440260 (1) (see all 12)
    nsclc 50.7 31 16567021 (1), 16330885 (1), 14641989 (1), 14757534 (1) (see all 20)
    cancer 49.1 84 18172817 (3), 18320010 (2), 7804359 (2), 9568183 (2) (see all 62)
    keratitis herpetic 47.7 2 9746072 (1)
    glioma 46.7 22 12639307 (3), 18079358 (2), 20357517 (2), 9823022 (1) (see all 15)

    Genetic Association Database (GAD): TKT

    Export disorders for TKT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TKT gene, integrated from 10 sources (see all 1082):
    (articles sorted by number of sources associating them with TKT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase. (PubMed id 1567394)1, 2, 3, 9 Abedinia M.... Mattick J.S. (Biochem. Biophys. Res. Commun. 1992)
    2. Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke- Korsakoff individuals. (PubMed id 8419340)1, 2, 9 McCool B.A.... Singleton C.K. (J. Biol. Chem. 1993)
    3. The crystal structure of human transketolase and new insights into its mode of action. (PubMed id 20667822)1, 2 Mitschke L....Tittmann K. (J. Biol. Chem. 2010)
    4. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (Nat. Genet. 2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase. (PubMed id 9115179)1, 2 Schenk G.... Nixon P.F. (J. Mol. Evol. 1997)
    10. Transketolase is a major protein in the mouse cornea. (PubMed id 8969223)1, 9 Sax C.M....Piatigorsky J. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7086 HGNC: 11834 AceView: TKT Ensembl:ENSG00000163931 euGenes: HUgn7086
    ECgene: TKT Kegg: 7086 H-InvDB: TKT

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TKT Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Transketolase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TKT gene:
    Search GeneIP for patents involving TKT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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