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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TKT Gene

protein-coding   GIFtS: 66
GCID: GC03M053258

Transketolase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
transketolase1 2
TK2 3
EC 2.2.1.13 8
Wernicke-Korsakoff Syndrome1
TKT12

External Ids:    HGNC: 118341   Entrez Gene: 70862   Ensembl: ENSG000001639317   OMIM: 6067815   UniProtKB: P294013   

Export aliases for TKT gene to outside databases

Previous GC identifers: GC03M052351 GC03M052511 GC03M053114 GC03M053217 GC03M053233


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TKT Gene:
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to
glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms
have been observed for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for TKT Gene: 
TKT (transketolase) is a protein-coding gene. Diseases associated with TKT include spondylometaepiphyseal dysplasia short limb-hand type, and transaldolase deficiency, and among its related super-pathways are Pentose phosphate pathway (hexose monophosphate shunt) and Metabolic pathways. GO annotations related to this gene include protein homodimerization activity and transketolase activity. An important paralog of this gene is TKTL2.

UniProtKB/Swiss-Prot: TKT_HUMAN, P29401
Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a
covalent intermediate with the cofactor thiamine pyrophosphate




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TKT gene promoter:
         NF-1   Sp1   p53   HFH-1   LUN-1   Egr-4   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTKT promoter sequence
   Search SABiosciences Chromatin IP Primers for TKT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TKT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p14.3

TKT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TKT gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M053258:  view genomic region     (about GC identifiers)

Start:
53,258,723 bp from pter      End:
53,290,130 bp from pter
Size:
31,408 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TKT_HUMAN, P29401 (See protein sequence)
Recommended Name: Transketolase  
Size: 623 amino acids; 67878 Da
Cofactor: Binds 1 magnesium ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+)
and Co(2+)
Cofactor: Binds 1 thiamine pyrophosphate per subunit
Subunit: Homodimer
2 PDB 3D structures from and Proteopedia for TKT:
3MOS (3D)        3OOY (3D)    
Secondary accessions: A8K089 B4DE31 E7EPA7 Q8TBA3 Q96HH3
Alternative splicing: 2 isoforms:  P29401-1   P29401-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TKT: NX_P29401

Explore proteomics data for TKT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29401

  • 4/29 DME Specific Peptides for TKT (P29401) (see all 29)
     GGIGEAV  LDNLVAI  GSHCGVS  DKASYRV 

    TKT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TKT Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001055.1  NP_001128527.1  NP_001244957.1  

    ENSEMBL proteins: 
     ENSP00000417773   ENSP00000405455   ENSP00000413503   ENSP00000391481   ENSP00000418340  
     ENSP00000417312   ENSP00000296289  
    Reactome Protein details: P29401
    Human Recombinant Protein Products for TKT: 
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    OriGene Protein Over-expression Lysate for TKT
    OriGene MassSpec for TKT 
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    Novus Biologicals TKT Proteins
    Novus Biologicals TKT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TKT
    Cloud-Clone Corp. Proteins for TKT 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005777peroxisome ISS--
    GO:0005829cytosol TAS--

    TKT for ontologies           About GeneDecksing



    TKT Antibody Products: 
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    Assay Products for TKT: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TKT 
    Cloud-Clone Corp. CLIAs for TKT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR005474 Transketolase_N
     IPR005476 Transketolase_C
     IPR009014 Transketo_C/Pyr-ferredox_oxred
     IPR005475 Transketolase-like_Pyr-bd
     IPR020826 Transketolase_BS

    Graphical View of Domain Structure for InterPro Entry P29401

    ProtoNet protein and cluster: P29401

    2 Blocks protein domains:
    IPB005475 Transketolase
    IPB005476 Transketolase


    UniProtKB/Swiss-Prot: TKT_HUMAN, P29401
    Similarity: Belongs to the transketolase family


    TKT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TKT_HUMAN, P29401
    Function: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a
    covalent intermediate with the cofactor thiamine pyrophosphate
    Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose
    5-phosphate

         Genatlas biochemistry entry for TKT:
    transketolase,pentose phosphate pathway

         Enzyme Number (IUBMB): EC 2.2.1.11 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004802transketolase activity IDA--
    GO:0016624oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor ----
    GO:0042803protein homodimerization activity IDA--
    GO:0046872metal ion binding IEA--
         
    TKT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TKT:
     Increased HPV18 LCR reporter a 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tkt):
     adipose tissue  behavior/neurological  cardiovascular system  endocrine/exocrine gland  growth/size 
     liver/biliary system  mortality/aging  nervous system  renal/urinary system  reproductive system 
     vision/eye 

    TKT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tkttm1Jpi for TKT

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TKT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TKT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TKT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TKT 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TKT
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TKT:
    hsa-miR-1323 hsa-miR-616* hsa-miR-514b-5p hsa-miR-513c hsa-miR-548o hsa-miR-371-5p hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of TKT 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TKT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TKT About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Pentose phosphate pathway (hexose monophosphate shunt)
    Pentose phosphate pathway (hexose monophosphate shunt)0.88
    pentose phosphate pathway0.67
    Pentose Phosphate Pathway0.88
    pentose phosphate pathway (non-oxidative branch)0.62
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37
    4Regulation of Insulin Secretion
    Integration of energy metabolism0.74
    5MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TKT
        Glucose / Energy Metabolism

    3 BioSystems Pathways for TKT
        pentose phosphate pathway
    Pentose Phosphate Pathway
    pentose phosphate pathway (non-oxidative branch)

    5        Reactome Pathways for TKT
        Metabolism of carbohydrates
    Pentose phosphate pathway (hexose monophosphate shunt)
    Metabolism
    Integration of energy metabolism
    Insulin effects increased synthesis of Xylulose-5-Phosphate


    4         Kegg Pathways  (Kegg details for TKT):
        Pentose phosphate pathway
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids


    TKT for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TKT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/127 Interacting proteins for TKT (P294012, 3 ENSP000004054554) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3304676 I2D: score=2 STRING: ENSP00000309503
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
    GABARAPL2P605203, ENSP000000372434I2D: score=1 STRING: ENSP00000037243
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005999xylulose biosynthetic process TAS--
    GO:0006098pentose-phosphate shunt TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0008152metabolic process ----

    TKT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TKT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TKT

    10/13 HMDB Compounds for TKT (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Beta-D-Fructose 6-phosphatebeta-D-Fructose 6-phosphate (see all 2)----
    CalciumCa (see all 2)7440-70-2--
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    D-Ribose 5-phosphateD-Ribose 5-phosphate (see all 11)3615-55-2--
    D-Ribulose 5-phosphateD-Ribulose 5-phosphate (see all 5)4151-19-3--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    Fructose 6-phosphateD-Fructose 6-phosphate (see all 13)643-13-0--
    MagnesiumMagnesium (see all 2)7439-95-4--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--

    10/152 Novoseek inferred chemical compound relationships for TKT gene (see all 152)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 93.6 736 11923581 (4), 9127632 (3), 2210063 (3), 7705935 (2) (see all 99)
    ganciclovir 87.7 190 16390269 (4), 8690797 (4), 9923018 (3), 10945770 (3) (see all 89)
    thiamine pyrophosphate 84.2 93 16097940 (3), 7861245 (2), 19290028 (2), 17309441 (2) (see all 26)
    thiamine 80.3 99 9568183 (5), 7861245 (3), 11488910 (3), 9951304 (2) (see all 51)
    benfotiamine 79.3 9 16452468 (2), 16416271 (1), 12882930 (1), 18581039 (1) (see all 8)
    l-erythrulose 78.5 2 14505172 (1), 18224278 (1)
    bvdu 78.1 13 15168799 (2), 18066636 (1), 9415318 (1), 10188760 (1) (see all 5)
    acyclovir 78 100 11793392 (4), 11060773 (3), 10421406 (3), 10882609 (3) (see all 45)
    tyrosine 77.3 354 18182111 (2), 9115253 (2), 8188658 (2), 8628282 (2) (see all 99)
    bv-arau 77.2 19 15168799 (2), 8295566 (2), 8849252 (1), 18066636 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about TKT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TKT gene (4 alternative transcripts): 
    NM_001064.3  NM_001135055.2  NM_001258028.1  NM_001135056.1  

    Unigene Cluster for TKT:

    Transketolase
    Hs.89643  [show with all ESTs]
    Unigene Representative Sequence: NM_001135055
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462138(uc003dgo.3 uc003dgp.2 uc011beo.1 uc003dgq.3 uc011beq.2 uc011ber.2)
    ENST00000423525 ENST00000460343 ENST00000461139 ENST00000450814 ENST00000423516
    ENST00000469678 ENST00000460243 ENST00000472528 ENST00000494523 ENST00000466765
    ENST00000487660 ENST00000483706 ENST00000296289
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TKT:
    hsa-miR-1323 hsa-miR-616* hsa-miR-514b-5p hsa-miR-513c hsa-miR-548o hsa-miR-371-5p hsa-miR-373*
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    GenScript: all cDNA clones in your preferred vector (see all 2): TKT (NM_001064)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TKT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TKT
    Sirion Biotech Customized lentivirus for stable overexpression of TKT 
                         Customized lentivirus expression plasmids for stable overexpression of TKT 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TKT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TKT

    Additional mRNA sequence: 

    AK093667.1 AK223614.1 AK289454.1 AK293438.1 AK301231.1 AK303191.1 AK309482.1 BC002433.2 
    BC008615.1 BC009970.2 BC024026.2 BX647248.1 L12711.1 NR_047580.1 U55017.1 X67688.1 

    24/61 DOTS entries (see all 61):

    DT.100889803  DT.419434  DT.100889811  DT.95146007  DT.95145910  DT.100889832  DT.100889827  DT.100889826 
    DT.91950120  DT.100889843  DT.91960759  DT.100889813  DT.100889847  DT.91999919  DT.100889819  DT.92384439 
    DT.92000149  DT.120844582  DT.202104  DT.91664093  DT.91697449  DT.100889859  DT.100889860  DT.100753730 

    24/1420 AceView cDNA sequences (see all 1420):

    CB139769 BE018255 BI255115 AA401829 BI850585 BF724165 BU177161 BC008615 
    CR604669 BU539259 BP361919 AA075927 BM836792 BE794152 BE257373 BQ687658 
    BQ029337 BG740025 BI771366 BU155092 BX421991 BU627526 AU131011 AW075799 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for TKT (see all 15)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a ·
    SP1:                                      -                       -     -                       -     -                             -                       -   
    SP2:                                      -                       -     -                       -     -                             -                       -   
    SP3:                    -     -     -     -     -                 -     -                       -     -                             -                       -   
    SP4:                                                                                                                                -                 -         
    SP5:                                                                                                                                                        -   

    ExUns: 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                          -                             -         
    SP2:                          -                                       
    SP3:                          -                                       
    SP4:                          -                                       
    SP5:                          -                                       


    ECgene alternative splicing isoforms for TKT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TKT expression in normal human tissues (normalized intensities)      TKT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCCATCT
    TKT Expression
    About this image


    TKT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/49 selected tissues (see all 49) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             brain/forebrain/telencephalon   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
             sensory organ/eye/cornea   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             Ureter
             urinary bladder ; urothelial cells   
             visceral organ/bladder   

    See TKT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TKT

    SOURCE GeneReport for Unigene cluster: Hs.89643
        SABiosciences Expression via Pathway-Focused PCR Array including TKT: 
              Glucose Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TKT gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tkt1 , 5 transketolase1, 5 87.35(n)1
    94.86(a)1
      14 (18.79 cM)5
    218811  NM_009388.51  NP_033414.11 
     305483595 
    chicken
    (Gallus gallus)
    Aves TKT1 transketolase 74.64(n)
    84.59(a)
      415991  XM_414333.3  XP_414333.2 
    lizard
    (Anolis carolinensis)
    Reptilia TKT6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    2(160044020-160085807)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687852 transketolase 76.31(n)    BC060361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5575181 transketolase-like 71.21(n)
    71.43(a)
      557518  XM_680598.2  XP_685690.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80363 transketolase 58(a)
    (best of 2)
      85A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea F01G10.13 transketolase 60(a)   IV(10243790-10245827)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TKL1(YPR074C)4 Transketolase, similar to Tkl2p; catalyzes conversion more   --   16(694838-692796) 856188  NP_015399.1 


    ENSEMBL Gene Tree for TKT (if available)
    TreeFam Gene Tree for TKT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TKT gene
    TKTL22  TKTL12  
    4 SIMAP similar genes for TKT using alignment to 5 protein entries:     TKT_HUMAN (see all proteins):
    DKFZp686J13123    TKTL2    DKFZp434B129    TKTL1

    TKT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/881 SNPs in TKT are shown (see all 881)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126326711,2
    C,F,H--53190789(+) AGGCTG/ATTCCC 1 -- ds500116Minor allele frequency- A:0.03NS EA NA 1856
    rs1164167961,2
    C,F--53191044(+) CTCTGG/ACACTG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs1392437231,2
    --53191045(+) TCTGGC/TACTGC 1 -- ds50010--------
    rs352610101,2
    C--53191073(+) GGGGG-/GCAATT 1 -- ds50010--------
    rs1157792091,2
    F--53191147(+) CGTGTC/TCACAA 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs10560821,2
    C--53191177(-) CCTCAG/AAGCTG 1 -- ut31 ese33Minor allele frequency- A:0.00MN NA 188
    rs115405291,2
    C--53191348(+) TGTGAG/TGGCAG 1 -- ut310--------
    rs130939361,2
    C,F,H--53191378(+) CAGGTC/TGGGGC 1 -- ut31 ese38Minor allele frequency- T:0.10NS EA NA 532
    rs10560761,2
    C--53191419(-) AGCTTC/TTGATG 1 -- ut31 ese30--------
    rs1169905371,2
    F--53191460(+) CCCCAT/CTGGCA 1 -- ut311Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for TKT (53258723 - 53290130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TKT:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1009267CNV Insertion20482838
    esv1068681CNV Insertion17803354
    nsv834699CNV Loss17160897
    nsv3824CNV Loss18451855
    nsv517233CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606781    OMIM disorders: --

    20/134 diseases for TKT (see all 134):    About MalaCards
    spondylometaepiphyseal dysplasia short limb-hand type    transaldolase deficiency    beriberi    alcoholic psychosis
    eosinophilic disorders    herpetic keratitis    smallpox    wernicke-korsakoff syndrome
    thoracic cancer    keratitis    wernicke encephalopathy    thanatophoric dysplasia
    cowpox    herpes simplex    pfeiffer syndrome    herpes zoster
    post-transplant lymphoproliferative disease    gliosarcoma    senile cataract    carcinoid syndrome

    3 diseases from the University of Copenhagen DISEASES database for TKT:
    Wernicke-Korsakoff syndrome     Beriberi     Wernicke encephalopathy

    TKT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for TKT gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 85.1 168 12475412 (3), 12050148 (2), 15483667 (2), 2153540 (1) (see all 99)
    thiamine deficiency 75.6 16 7861245 (2), 8683340 (2), 8949966 (2), 8059170 (1) (see all 12)
    korsakoff syndrome 70.3 12 8445392 (2), 7596328 (1), 7861132 (1), 8279670 (1) (see all 9)
    tumors 57.3 269 1433372 (6), 10794295 (5), 11245445 (5), 7705935 (4) (see all 99)
    thyroid papillary carcinoma 53.4 8 7519046 (1), 1437145 (1), 8570194 (1), 8628282 (1) (see all 7)
    myeloid leukemia chronic 51.1 12 19536317 (1), 2304355 (1), 19643477 (1), 12440260 (1) (see all 12)
    nsclc 50.7 31 16567021 (1), 16330885 (1), 14641989 (1), 14757534 (1) (see all 20)
    cancer 49.1 84 18172817 (3), 18320010 (2), 7804359 (2), 9568183 (2) (see all 62)
    keratitis herpetic 47.7 2 9746072 (1)
    glioma 46.7 22 12639307 (3), 18079358 (2), 20357517 (2), 9823022 (1) (see all 15)

    Genetic Association Database (GAD): TKT

    Export disorders for TKT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TKT gene, integrated from 9 sources (see all 1079):
    (articles sorted by number of sources associating them with TKT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase. (PubMed id 1567394)1, 2, 3, 9 Abedinia M.... Mattick J.S. (1992)
    2. Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke- Korsakoff individuals. (PubMed id 8419340)1, 2, 9 McCool B.A.... Singleton C.K. (1993)
    3. The crystal structure of human transketolase and new insights into its mode of action. (PubMed id 20667822)1, 2 Mitschke L....Tittmann K. (2010)
    4. Common variants in 22 loci are associated with QRS du ration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Molecular evolutionary analysis of the thiamine-diphosphate-dependent enzyme, transketolase. (PubMed id 9115179)1, 2 Schenk G.... Nixon P.F. (1997)
    10. Transketolase is a major protein in the mouse cornea. (PubMed id 8969223)1, 9 Sax C.M....Piatigorsky J. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7086 HGNC: 11834 AceView: TKT Ensembl:ENSG00000163931 euGenes: HUgn7086
    ECgene: TKT Kegg: 7086 H-InvDB: TKT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TKT Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Transketolase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TKT gene:
    Search GeneIP for patents involving TKT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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