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Aliases for TKFC Gene

Aliases for TKFC Gene

  • Triokinase/FMN Cyclase 2 3
  • DAK 3 4
  • Bifunctional ATP-Dependent Dihydroxyacetone Kinase/FAD-AMP Lyase (Cyclizing) 3
  • Dihydroxyacetone Kinase 2 Homolog (S. Cerevisiae) 2
  • Dihydroxyacetone Kinase 2 Homolog (Yeast) 2
  • ATP-Dependent Dihydroxyacetone Kinase 3
  • Dihydroxyacetone Kinase 2 Homolog 3
  • FAD-AMP Lyase Cyclic FMN Forming 3
  • FAD-AMP Lyase Cyclizing 3
  • Dha Kinase/FMN Cyclase 3
  • Glycerone Kinase 3
  • DHA Kinase 3
  • NET45 3

External Ids for TKFC Gene

Previous Symbols for TKFC Gene

  • DAK

Summaries for TKFC Gene

Entrez Gene Summary for TKFC Gene

  • This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TKFC Gene

TKFC (Triokinase/FMN Cyclase) is a Protein Coding gene. Among its related pathways are Metabolism and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.

UniProtKB/Swiss-Prot for TKFC Gene

  • Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.

Gene Wiki entry for TKFC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TKFC Gene

Genomics for TKFC Gene

Genomic Location for TKFC Gene

61,333,182 bp from pter
61,353,426 bp from pter
20,245 bases
Plus strand

Genomic View for TKFC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TKFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TKFC Gene

No data available for Regulatory Elements for TKFC Gene

Proteins for TKFC Gene

  • Protein details for TKFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)
    Protein Accession:
    Secondary Accessions:
    • Q2L9C1
    • Q53EQ9
    • Q9BVA7
    • Q9H895

    Protein attributes for TKFC Gene

    575 amino acids
    Molecular mass:
    58947 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Manganese or cobalt are requested for FAD-AMP lyase activity.;
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for TKFC Gene


neXtProt entry for TKFC Gene

Proteomics data for TKFC Gene at MOPED

Post-translational modifications for TKFC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TKFC Gene

No data available for DME Specific Peptides for TKFC Gene

Domains for TKFC Gene

Protein Domains for TKFC Gene


  • Contains 1 DhaK domain.:
    • Q3LXA3
  • Contains 1 DhaL domain.:
    • Q3LXA3
  • Belongs to the dihydroxyacetone kinase (DAK) family.:
    • Q3LXA3
genes like me logo Genes that share domains with TKFC: view

No data available for Gene Families for TKFC Gene

Function for TKFC Gene

Molecular function for TKFC Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.5 uM for dihydroxyacetone {ECO:0000269 PubMed:4688871}; KM=11 uM for glyceraldehyde {ECO:0000269 PubMed:4688871}; pH dependence: Optimum pH is 6.6. {ECO:0000269 PubMed:4688871};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + glycerone = ADP + glycerone phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: FAD = AMP + riboflavin cyclic-4,5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Each activity is inhibited by the substrate(s) of the other
UniProtKB/Swiss-Prot Function: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.

Gene Ontology (GO) - Molecular Function for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004371 glycerone kinase activity IDA 16289032
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0034012 FAD-AMP lyase (cyclizing) activity IDA 16289032
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TKFC: view

miRNA for TKFC Gene

miRTarBase miRNAs that target TKFC

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TKFC Gene

Localization for TKFC Gene

Gene Ontology (GO) - Cellular Components for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TKFC: view

Pathways for TKFC Gene

genes like me logo Genes that share pathways with TKFC: view

Pathways by source for TKFC Gene

Gene Ontology (GO) - Biological Process for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006000 fructose metabolic process TAS --
GO:0006071 glycerol metabolic process IEA --
GO:0016310 phosphorylation --
GO:0044262 cellular carbohydrate metabolic process IDA 16289032
genes like me logo Genes that share ontologies with TKFC: view

Transcripts for TKFC Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TKFC Gene

No ASD Table

Relevant External Links for TKFC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TKFC Gene

mRNA expression in normal human tissues for TKFC Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TKFC Gene

mRNA Expression by UniProt/SwissProt for TKFC Gene

Tissue specificity: Detected in erythrocytes (at protein level).
genes like me logo Genes that share expressions with TKFC: view

Orthologs for TKFC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TKFC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DAK 36
  • 99.36 (n)
  • 100 (a)
DAK 37
  • 100 (a)
(Bos Taurus)
Mammalia DAK 36
  • 89.57 (n)
  • 93.57 (a)
DAK 37
  • 93 (a)
(Canis familiaris)
Mammalia DAK 36
  • 89.62 (n)
  • 91.48 (a)
DAK 37
  • 91 (a)
(Mus musculus)
Mammalia Dak 36
  • 83.59 (n)
  • 85.39 (a)
Dak 16
Dak 37
  • 85 (a)
(Monodelphis domestica)
Mammalia DAK 37
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia DAK 37
  • 82 (a)
(Rattus norvegicus)
Mammalia Dak 36
  • 83.83 (n)
  • 85.91 (a)
(Gallus gallus)
Aves -- 37
  • 75 (a)
-- 37
  • 73 (a)
DAK 36
  • 73.83 (n)
  • 77.41 (a)
(Anolis carolinensis)
Reptilia DAK 37
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dak 36
  • 62.3 (n)
  • 63.64 (a)
(Danio rerio)
Actinopterygii dak 36
  • 60.59 (n)
  • 55.96 (a)
dak 37
  • 56 (a)
(Caenorhabditis elegans)
Secernentea W02H5.8 36
  • 49.38 (n)
  • 43.49 (a)
W02H5.8 37
  • 40 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER139C 36
  • 47.79 (n)
  • 40.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAK1 37
  • 33 (a)
DAK2 37
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G17770 36
  • 49.03 (n)
  • 43.61 (a)
(Oryza sativa)
Liliopsida Os.46088 36
Os03g0719300 36
  • 48.95 (n)
  • 42.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04400 36
  • 46.06 (n)
  • 34.69 (a)
Species with no ortholog for TKFC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TKFC Gene

Gene Tree for TKFC (if available)
Gene Tree for TKFC (if available)

Paralogs for TKFC Gene

No data available for Paralogs for TKFC Gene

Variants for TKFC Gene

Sequence variations from dbSNP and Humsavar for TKFC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs752122 -- 61,336,176(-) TAAGA(C/T)TGGTT intron-variant, upstream-variant-2KB
rs2167883 -- 61,348,231(-) TCTGA(A/G)AAAAC utr-variant-3-prime, intron-variant
rs2260655 -- 61,341,502(+) TGGTC(A/G)CCAAG missense, reference
rs2305465 -- 61,345,330(+) TCTGT(C/T)CTGCT reference, synonymous-codon
rs2512809 -- 61,339,053(-) TGGAA(A/G)GAGTG intron-variant

Relevant External Links for TKFC Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for TKFC Gene

Disorders for TKFC Gene

No disorders were found for TKFC Gene.

No data available for UniProtKB/Swiss-Prot for TKFC Gene

Publications for TKFC Gene

  1. Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases. (PMID: 16289032) Cabezas A. … Cameselle J.C. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  2. Dihydroxyacetone metabolism by human erythrocytes: demonstration of triokinase activity and its characterization. (PMID: 4688871) Beutler E. … Guinto E. (Blood 1973) 3 4
  3. Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements. (PMID: 24569995) Rodrigues J.R. … Cameselle J.C. (J. Biol. Chem. 2014) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TKFC Gene

  • Addgene plasmids for TKFC

Sources for TKFC Gene

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