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Aliases for TKFC Gene

Aliases for TKFC Gene

  • Triokinase And FMN Cyclase 2 3 5
  • Bifunctional ATP-Dependent Dihydroxyacetone Kinase/FAD-AMP Lyase (Cyclizing) 3 4
  • Triokinase/FMN Cyclase 2 3
  • DAK 3 4
  • Dihydroxyacetone Kinase 2 Homolog (S. Cerevisiae) 2
  • Testis Tissue Sperm-Binding Protein Li 84P 3
  • Dihydroxyacetone Kinase 2 Homolog (Yeast) 2
  • ATP-Dependent Dihydroxyacetone Kinase 3
  • Dihydroxyacetone Kinase 2 Homolog 3
  • FAD-AMP Lyase Cyclic FMN Forming 3
  • FAD-AMP Lyase (Cyclizing) 2
  • FAD-AMP Lyase Cyclizing 3
  • Dha Kinase/FMN Cyclase 3
  • Glycerone Kinase 3
  • DHA Kinase 3
  • NET45 3

External Ids for TKFC Gene

Previous HGNC Symbols for TKFC Gene

  • DAK

Summaries for TKFC Gene

Entrez Gene Summary for TKFC Gene

  • This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TKFC Gene

TKFC (Triokinase And FMN Cyclase) is a Protein Coding gene. Among its related pathways are Fructose metabolism and Innate Immune System. GO annotations related to this gene include glycerone kinase activity and triokinase activity.

UniProtKB/Swiss-Prot for TKFC Gene

  • Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).

Gene Wiki entry for TKFC Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TKFC Gene

Genomics for TKFC Gene

Regulatory Elements for TKFC Gene

Enhancers for TKFC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G061365 1.5 Ensembl ENCODE dbSUPER 12.4 +35.4 35354 5.7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B YY1 TCF12 GATA2 FOS TMEM216 DDB1 TKFC GC11P061375 CYB561A3
GH11G061377 1.4 FANTOM5 Ensembl ENCODE 12.5 +45.7 45722 2.9 BCOR FOXA2 JUN ZMYM3 CEBPG RFX5 YY1 ZFHX2 ADNP SCRT2 DDB1 TKFC DAGLA CYB561A3 SDHAF2 VPS37C CPSF7 SLC15A3 TMEM138 GC11P061375
GH11G061391 1.4 Ensembl ENCODE 12.1 +59.3 59328 3.0 HDGF PKNOX1 FOXA2 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 TMEM216 TMEM138 DDB1 TKFC VPS37C RN7SL23P PIR41666 GC11P061399
GH11G061428 1.4 ENCODE dbSUPER 10.3 +96.7 96749 3.3 HNRNPUL1 PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 TMEM216 DDB1 TKFC CPSF7 SDHAF2 ENSG00000256591
GH11G061385 1.2 Ensembl ENCODE 11.9 +52.3 52319 1.0 ELF3 CBX3 RB1 ARID4B RAD21 RFX5 ZNF366 EGR1 SCRT2 ZNF143 DDB1 TKFC TMEM216 GC11P061375
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TKFC on UCSC Golden Path with GeneCards custom track

Promoters for TKFC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040245 -282 1801 HDGF PKNOX1 FOXA2 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for TKFC Gene

Chromosome:
11
Start:
61,333,182 bp from pter
End:
61,353,295 bp from pter
Size:
20,114 bases
Orientation:
Plus strand

Genomic View for TKFC Gene

Genes around TKFC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TKFC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TKFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TKFC Gene

Proteins for TKFC Gene

  • Protein details for TKFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LXA3-TKFC_HUMAN
    Recommended name:
    Triokinase/FMN cyclase
    Protein Accession:
    Q3LXA3
    Secondary Accessions:
    • Q2L9C1
    • Q53EQ9
    • Q9BVA7
    • Q9H895

    Protein attributes for TKFC Gene

    Size:
    575 amino acids
    Molecular mass:
    58947 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with IFIH1 (via the CARD domains), the interaction is inhibited by viral infection (PubMed:17600090).

    Alternative splice isoforms for TKFC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TKFC Gene

Post-translational modifications for TKFC Gene

  • Ubiquitination at Lys372 and Lys522
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TKFC Gene

Domains & Families for TKFC Gene

Protein Domains for TKFC Gene

Graphical View of Domain Structure for InterPro Entry

Q3LXA3

UniProtKB/Swiss-Prot:

TKFC_HUMAN :
  • DhaK and DhaL domains have differential roles, individually DhaK is inactive and DhaL displays cyclase but not kinase activity.
  • Belongs to the dihydroxyacetone kinase (DAK) family.
Domain:
  • DhaK and DhaL domains have differential roles, individually DhaK is inactive and DhaL displays cyclase but not kinase activity.
Family:
  • Belongs to the dihydroxyacetone kinase (DAK) family.
genes like me logo Genes that share domains with TKFC: view

No data available for Gene Families for TKFC Gene

Function for TKFC Gene

Molecular function for TKFC Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.5 uM for dihydroxyacetone {ECO:0000269 PubMed:4688871}; KM=11 uM for glyceraldehyde {ECO:0000269 PubMed:4688871}; KM=1.55 uM for dihydroxyacetone {ECO:0000269 PubMed:24569995}; KM=43.2 uM for ATP {ECO:0000269 PubMed:24569995}; KM=18.1 uM for glyceraldehyde {ECO:0000269 PubMed:24569995}; KM=7 uM for FAD {ECO:0000269 PubMed:24569995}; KM=12 uM for ADP-glucose {ECO:0000269 PubMed:24569995}; KM=317 uM for UDP-glucose {ECO:0000269 PubMed:24569995}; KM=263 uM for UDP-galactose {ECO:0000269 PubMed:24569995}; pH dependence: Optimum pH is 6.6. {ECO:0000269 PubMed:4688871};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + glycerone = ADP + glycerone phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
FAD = AMP + riboflavin cyclic-4,5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Each activity is inhibited by the substrate(s) of the other.
UniProtKB/Swiss-Prot Function:
Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response (PubMed:17600090).

Gene Ontology (GO) - Molecular Function for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004371 glycerone kinase activity IDA,IEA 4688871
GO:0005515 protein binding IPI 17600090
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with TKFC: view
genes like me logo Genes that share phenotypes with TKFC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TKFC

CRISPR Products

miRNA for TKFC Gene

miRTarBase miRNAs that target TKFC

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TKFC Gene

Localization for TKFC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TKFC gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
peroxisome 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TKFC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TKFC Gene

Pathways & Interactions for TKFC Gene

genes like me logo Genes that share pathways with TKFC: view

Gene Ontology (GO) - Biological Process for TKFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006071 glycerol metabolic process IEA --
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA --
GO:0039534 negative regulation of MDA-5 signaling pathway IDA 17600090
GO:0044262 cellular carbohydrate metabolic process IDA 4688871
genes like me logo Genes that share ontologies with TKFC: view

No data available for SIGNOR curated interactions for TKFC Gene

Drugs & Compounds for TKFC Gene

(6) Drugs for TKFC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Dihydroxyacetone Experimental Pharma 0
Glyceraldehyde-3-Phosphate Experimental Pharma 0

(2) Additional Compounds for TKFC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
glyceraldehyde
  • (+/-)-2,3-dihydroxy-Propanal
  • (+/-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • alpha,beta-Dihydroxypropionaldehyde
56-82-6
genes like me logo Genes that share compounds with TKFC: view

Transcripts for TKFC Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TKFC Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
SP1: - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - -
SP7: - -
SP8: - - - - - -
SP9:
SP10:
SP11: -
SP12: - -
SP13:
SP14: - -
SP15: -

ExUns: 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b
SP1: - -
SP2:
SP3: - - - - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for TKFC Gene

GeneLoc Exon Structure for
TKFC
ECgene alternative splicing isoforms for
TKFC

Expression for TKFC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TKFC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TKFC Gene

This gene is overexpressed in Liver, secretome (26.0) and Liver (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TKFC Gene



Protein tissue co-expression partners for TKFC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TKFC Gene:

TKFC

mRNA Expression by UniProt/SwissProt for TKFC Gene:

Q3LXA3-TKFC_HUMAN
Tissue specificity: Detected in erythrocytes (at protein level).

Evidence on tissue expression from TISSUES for TKFC Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Kidney(4.4)
  • Thyroid gland(4.3)
  • Intestine(3.3)
  • Blood(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with TKFC: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TKFC Gene

Orthologs for TKFC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TKFC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAK 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia DAK 34 35
  • 89.62 (n)
cow
(Bos Taurus)
Mammalia DAK 34 35
  • 89.57 (n)
rat
(Rattus norvegicus)
Mammalia Dak 34
  • 83.83 (n)
mouse
(Mus musculus)
Mammalia Dak 34 35
  • 83.59 (n)
Tkfc 16
oppossum
(Monodelphis domestica)
Mammalia DAK 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAK 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 75 (a)
OneToMany
DAK 34
  • 73.83 (n)
-- 35
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia DAK 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dak 34
  • 62.3 (n)
zebrafish
(Danio rerio)
Actinopterygii dak 34 35
  • 60.59 (n)
worm
(Caenorhabditis elegans)
Secernentea W02H5.8 34 35
  • 49.38 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER139C 34
  • 47.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAK2 35
  • 33 (a)
OneToMany
DAK1 35
  • 33 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G17770 34
  • 49.03 (n)
rice
(Oryza sativa)
Liliopsida Os03g0719300 34
  • 48.95 (n)
Os.46088 34
bread mold
(Neurospora crassa)
Ascomycetes NCU04400 34
  • 46.06 (n)
Species where no ortholog for TKFC was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TKFC Gene

ENSEMBL:
Gene Tree for TKFC (if available)
TreeFam:
Gene Tree for TKFC (if available)

Paralogs for TKFC Gene

No data available for Paralogs for TKFC Gene

Variants for TKFC Gene

Sequence variations from dbSNP and Humsavar for TKFC Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000059022 -- 61,335,536(+) TCATT(G/T)TGTGT intron-variant
rs1000205947 -- 61,342,357(+) ACTCC(C/T)GCCCA intron-variant
rs1000367641 -- 61,335,813(+) TTTTG(A/T)GACGG intron-variant
rs1000683231 -- 61,334,253(+) CCCTT(C/G)CCTTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001022368 -- 61,351,520(+) TCCTG(A/C)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TKFC Gene

Variant ID Type Subtype PubMed ID
dgv662n106 CNV deletion 24896259
esv1545620 CNV deletion 17803354
esv1969466 CNV deletion 18987734
esv2497950 CNV deletion 19546169
esv2744588 CNV deletion 23290073
esv3293 CNV loss 18987735
esv3547872 CNV deletion 23714750
esv5881 CNV loss 19470904
nsv1070461 CNV deletion 25765185
nsv1147756 CNV deletion 26484159
nsv428259 CNV gain+loss 18775914
nsv832177 CNV loss 17160897

Variation tolerance for TKFC Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TKFC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TKFC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TKFC Gene

Disorders for TKFC Gene

Relevant External Links for TKFC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TKFC

No disorders were found for TKFC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TKFC Gene

Publications for TKFC Gene

  1. Bifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movements. (PMID: 24569995) Rodrigues J.R. … Cameselle J.C. (J. Biol. Chem. 2014) 2 3 4 64
  2. Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases. (PMID: 16289032) Cabezas A. … Cameselle J.C. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  3. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. (PMID: 17600090) Diao F. … Shu H.B. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TKFC Gene

Sources for TKFC Gene

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